keyword
https://read.qxmd.com/read/36913931/case-report-an-unusual-case-of-subacute-sclerosing-panencephalitis-with-distinctive-clinical-and-neuroimaging-features
#21
Ravindra Kumar Garg, Shweta Pandey, Harish Nigam, D B Keerthiraj, Imran Rizvi, Neeraj Kumar, Ravi Uniyal, Hardeep Singh Malhotra, Praveen Kumar Sharma
Subacute sclerosing panencephalitis (SSPE) is a relentlessly progressive brain disorder with invariable mortality. Subacute sclerosing panencephalitis is common in measles-endemic areas. We report an unusual SSPE patient with distinctive clinical and neuroimaging features. A 9-year-old boy came with a 5-month history of spontaneously dropping objects from both hands. Subsequently, he developed mental decline, a loss of interest in his surroundings, decreased verbal output, and inappropriate crying and laughing along with generalized periodic myoclonus...
May 3, 2023: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/36686352/anti-leucine-rich-glioma-inactivated-protein-1-encephalitis-with-sleep-disturbance-as-the-first-symptom-a-case-report-and-review-of-literature
#22
De-Lian Kong
BACKGROUND: Anti-leucine-rich glioma inactivated protein 1 (anti-LGI1) encephalitis is an infrequent type of autoimmune encephalitis (AE) characterized by acute or subacute cognitive and psychiatric disturbance, facio-brachial dystonic seizures (FBDSs), and hyponatremia. Anti-LGI1 AE has increasingly been considered a primary form of AE. Early identification and treatment of this disease are clearly very important. CASE SUMMARY: Here, we report that a male patient developed severe anti-LGI1 encephalitis, which was initially misdiagnosed as a sleep disturbance...
January 16, 2023: World Journal of Clinical Cases
https://read.qxmd.com/read/36660180/oculogyric-crisis-after-initiation-of-aripiprazole-a-case-report-of-an-active-duty-service-member
#23
Nicole L Hadler, Yevin A Roh, David A Nissan
INTRODUCTION: Oculogyric crisis is an acute dystonic reaction characterized by sustained, bilateral, and upward deviation of the eyes. It is a relatively uncommon extrapyramidal side effect of antipsychotic medications. Aripiprazole is an atypical antipsychotic that is FDA-approved for the treatment of schizophrenia, bipolar disorder, Tourette's disorder, and treatment resistant major depressive disorder. Compared to other antipsychotics, it is thought to have a lower propensity for causing dystonic side effects...
2023: Case Reports in Psychiatry
https://read.qxmd.com/read/36483887/acute-dystonic-reaction-in-the-upper-extremity-following-anesthesia
#24
Mili Patel, Benjamin L Park
We present a case of an 83-year-old female who underwent carpal tunnel release with intravenous regional anesthesia (Bier block) and monitored anesthesia care (MAC). After surgery, the patient developed an abnormal motion of her upper extremity, which was treated as an acute dystonic reaction. Dystonic reactions can occasionally be seen as a post-anesthetic complication, but they are most often associated with antidopaminergic medications. Limbs are rarely affected by dystonic reactions, as they usually affect the head and neck...
November 2022: Curēus
https://read.qxmd.com/read/36454441/sleep-disorders-and-polysomnography-findings-in-patients-with-autoimmune-encephalitis
#25
JOURNAL ARTICLE
Irem Erkent, Bulent Elibol, Esen Saka, Serap Saygi, Irsel Tezer
BACKGROUND: Sleep disorders in patients with autoimmune encephalitis (AE) are increasingly reported. Early recognition and treatment have significant importance regarding the potential of sleep disorders' effect on morbidity and even mortality. There are a limited number of studies related to polysomnography (PSG) in these patients. Here, we report the clinical and PSG data of patients with AE and sleep disorders, with a particular interest in sleep-related breathing disorders (SRBD)...
April 2023: Neurological Sciences
https://read.qxmd.com/read/36405657/diphenhydramine-induced-acute-dystonia-a-case-report
#26
Danielle Abou Khater, Rafi Daou, Ali Al Dailaty, Mariana Helou
Acute dystonia has notably been a challenge in the emergency unit. Drug-induced dystonia is reported in a limited number of cases in the literature. Rarely, diphenhydramine was found to be the culprit. We report the case of a 25-year-old female patient who developed an acute dystonic reaction following the administration of 25 mg of intravenous diphenhydramine as a treatment for an allergic reaction. The patient was given 5 mg diazepam, admitted for monitoring, and discharged home. Diphenhydramine-induced acute dystonia is a user drug-induced threatening reaction that warrants further investigation on the metabolism of these drugs and the contributing phenotypes to this adverse reaction...
2022: Pan African Medical Journal
https://read.qxmd.com/read/36401981/a-novel-splicing-scn2a-mutation-in-an-adolescent-with-low-functioning-autism-acute-dystonic-movement-disorder-and-late-onset-generalized-epilepsy
#27
JOURNAL ARTICLE
Marianna Alagia, Simona Fecarotta, Alfonso Romano, Elena Parrini, Gianfranca Auricchio, Maria Giuseppina Miano, Gaetano Terrone
No abstract text is available yet for this article.
October 27, 2022: Pediatric Neurology
https://read.qxmd.com/read/36354229/-use-of-central-anticholinergics-in-2022
#28
JOURNAL ARTICLE
E Parmentier, F Depierreux, P Maquet
Cholinergic antagonists have been used for 60 years in the treatment of movement disorders. Their effect arises from a modulating activity within basal ganglia motor circuitry. Due to diffuse distribution among many organs, anticholinergic medications have numerous adverse effects. Nowadays, the indication of these molecules in the treatment of Parkinson disease is reduced, due to more effective and better tolerated alternatives. Iatrogenic parkinsonism is hardly alleviated by anticholinergics. These medications allow to prevent acute dystonic reactions induced by highly-dosed first generation antipsychotic agents...
November 2022: Revue Médicale de Liège
https://read.qxmd.com/read/36316880/a-chinese-female-patient-with-lgi1-and-mglur5-antibodies-a-case-report
#29
JOURNAL ARTICLE
Tiantian Huo, Xintong Luo, Jingru Zhao, Tianjun Wang, Jinghong Chen
RATIONALE: Anti-LGI1 antibody encephalitis and anti-mGluR5 are both uncommon encephalitis, and we report the first case of autoimmune encephalitis (AE) with dual seropositive antibodies of leucine-rich glioma-inactivated 1 (LGI1) and mGluR5. PATIENT CONCERNS: We present a case of AE with dual seropositive antibodies of LGI1 and mGluR5 in a 65-year-old woman who presented with sudden onset left faciobrachial dystonic seizures and unresponsive for 5 hours. DIAGNOSIS: The patient was diagnosed with anti-LGI1 AE and anti-mGluR5 AE mainly based on the clinical symptoms and further test of the antibody in serum and cerebral spinal fluid (CSF)...
October 28, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/36221165/recommendations-for-diagnosing-and-managing-individuals-with-glutaric-aciduria-type-1-third-revision
#30
JOURNAL ARTICLE
Nikolas Boy, Chris Mühlhausen, Esther M Maier, Diana Ballhausen, Matthias R Baumgartner, Skadi Beblo, Peter Burgard, Kimberly A Chapman, Dries Dobbelaere, Jana Heringer-Seifert, Sandra Fleissner, Karina Grohmann-Held, Gabriele Hahn, Inga Harting, Georg F Hoffmann, Frank Jochum, Daniela Karall, Vassiliki Konstantopoulous, Michael B Krawinkel, Martin Lindner, E M Charlotte Märtner, Jean-Marc Nuoffer, Jürgen G Okun, Barbara Plecko, Roland Posset, Katja Sahm, Sabine Scholl-Bürgi, Eva Thimm, Magdalena Walter, Monique Williams, Stephan Vom Dahl, Athanasia Ziagaki, Johannes Zschocke, Stefan Kölker
Glutaric aciduria type 1 is a rare inherited neurometabolic disorder of lysine metabolism caused by pathogenic gene variations in GCDH (cytogenic location: 19p13.13), resulting in deficiency of mitochondrial glutaryl-CoA dehydrogenase (GCDH) and, consequently, accumulation of glutaric acid, 3-hydroxyglutaric acid, glutaconic acid, and glutarylcarnitine detectable by gas chromatography/mass spectrometry (organic acids) and tandem mass spectrometry (acylcarnitines). Depending on residual GCDH activity, biochemical high and low excreting phenotypes have been defined...
October 11, 2022: Journal of Inherited Metabolic Disease
https://read.qxmd.com/read/36187571/confusion-and-hallucination-in-a-geriatric-patient-pitfalls-of-a-rare-differential-case-report-of-an-anti-lgi1-encephalitis
#31
Luzia Meier, Wolfram Weinrebe, Jean-Marie Annoni, Jens A Petersen
BACKGROUND: Confusion and hallucinations in geriatric patients are frequent symptoms and typically associated with delirium, late-life psychosis or dementia syndromes. A far rarer but well-established differential in patients with rapid cognitive deterioration, acute psychosis, abnormal movements and seizures is autoimmune encephalitis. Exemplified by our case we highlight clinical and economic problems arising in management of geriatric patients with cognitive decline and psychotic symptoms...
2022: Clinical Interventions in Aging
https://read.qxmd.com/read/35853356/autoimmune-cerebellar-ataxia-associated-with-anti-leucine-rich-glioma-inactivated-protein-1-antibodies-two-pediatric-cases
#32
JOURNAL ARTICLE
Zhang Weihua, Ren Haitao, Deng Jie, Ren Changhong, Zhou Ji, Zhou Anna, Guan Hongzhi, Ren Xiaotun
OBJECTIVES: To report two pediatric cases of autoimmune cerebellar ataxia associated with the anti-Leucine-rich glioma-inactivated protein 1 (LGI1)antibodies. METHODS: The clinical features of the two patients were described retrospectively. The indirect immunofluorescence using transfected cells (cell-based assay, CBA) and the rat cerebellum (tissue-based assay, TBA) with the multi-antigen co-plate biochip mosaic techniques were used to detect the antibodies. Clinical and laboratory characteristics were described...
September 15, 2022: Journal of Neuroimmunology
https://read.qxmd.com/read/35725943/dbs-emergency-surgery-for-treatment-of-dystonic-storm-associated-with-rhabdomyolysis-and-acute-colitis-in-dyt-gnao1
#33
JOURNAL ARTICLE
Hind Chaib, Jan-Christoph Schoene-Bake, Assel Saryyeva, Thomas Jack, Hans Hartmann, Joachim K Krauss
INTRODUCTION: Patients with variants in the GNAO1 gene may present with life-threatening dystonic storm. There is little experience using pallidal deep brain stimulation (DBS) as an emergency treatment in such cases. CASE DESCRIPTION: We report on a 16-year-old girl with a variant in the GNAO1 gene (c.626G > T; p.(Arg209Leu)) who was admitted to the intensive care unit with medically refractory dystonic storm with secondary complications inducing rhabdomyolysis and acute colitis...
September 2022: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/35595970/long-term-evolution-and-prognostic-factors-of-epilepsy-in-limbic-encephalitis-with-lgi1-antibodies
#34
JOURNAL ARTICLE
Déborah Guery, Louis Cousyn, Vincent Navarro, Géraldine Picard, Véronique Rogemond, Alexandre Bani-Sadr, Natalia Shor, Bastien Joubert, Sergio Muñiz-Castrillo, Jérome Honnorat, Sylvain Rheims
OBJECTIVE: To characterize the evolution of epilepsy in patients with leucine-rich glioma inactivated 1 antibody-associated (LGI1ab) limbic encephalitis, including factors associated with drug-resistant epilepsy (DRE). METHODS: Retrospective analysis of patients with LGI1 encephalitis managed at two tertiary epilepsy centers between 2005 and 2019 and whose samples were confirmed by the French Reference Center of Paraneoplastic Neurological Syndromes. Raw clinical, biological, EEG, and MRI data were reviewed...
September 2022: Journal of Neurology
https://read.qxmd.com/read/35490341/a-systematic-review-of-the-effectiveness-and-safety-of-droperidol-for-pediatric-agitation-in-acute-care-settings
#35
REVIEW
Shannon C Ramsden, Alba Pergjika, Aron C Janssen, Sukhraj Mudahar, Andrea Fawcett, John T Walkup, Jennifer A Hoffmann
OBJECTIVE: Agitation in children in acute care settings poses significant patient and staff safety concerns. While behavioral approaches are central to reducing agitation and oral medications are preferred, parenteral medications are used when necessary to promote safety. The goal of this systematic review was to evaluate the effectiveness and safety of an ultra-short-acting parenteral medication, droperidol, for the management of acute, severe agitation in children in acute care settings...
December 2022: Academic Emergency Medicine
https://read.qxmd.com/read/35489029/acute-hyperkinetic-movement-disorders-as-a-multifactorial-pharmacodynamic-drug-interaction-between-methylphenidate-and-risperidone-in-children-and-adolescents
#36
JOURNAL ARTICLE
Mohamed Mohamoud, Qi Chen, David Croteau, Carmen Cheng, Keith Burkhart, Donna A Volpe, Cindy Kortepeter, Dorothy Demczar, Marc Stone
PURPOSE/BACKGROUND: Acute hyperkinetic movement disorders have been reported with the concomitant use of attention-deficit/hyperactivity disorder (ADHD) stimulants and antipsychotics in children and adolescents. We analyzed postmarketing reports of suspected acute hyperkinetic movement disorder associated with concomitant use of ADHD stimulants and antipsychotics. METHODS/PROCEDURES: We searched for postmarketing reports of acute hyperkinetic movement disorders associated with concomitant use of ADHD stimulants-antipsychotics in the US Food and Drug Administration Adverse Event Reporting System through December 6, 2019...
May 2022: Journal of Clinical Psychopharmacology
https://read.qxmd.com/read/35087727/metoclopramide-induced-acute-dystonia-misdiagnosed-as-an-epileptic-seizure-in-a-lupus-patient
#37
Airenakho Emorinken, Oluwaseun Remi Agbadaola
Acute dystonic reactions are the most prevalent extrapyramidal adverse effects associated with metoclopramide. It could be mistaken for a variety of other conditions, such as seizures, tetanus, and encephalitis, to name a few possibilities. We present a case of a 26-year-old female misdiagnosed as having an epileptic seizure who was rushed to the emergency unit with an involuntary bilateral upward deviation of the eyes, spasm, stiffness, lateral deviation of the neck, and protrusion of the tongue. Symptoms occurred 36 hours after the commencement of metoclopramide, used to treat nausea and vomiting in the referring hospital...
December 2021: Journal of Epilepsy Research
https://read.qxmd.com/read/35070292/metoclopramide-induced-acute-dystonic-reaction-a-case-report
#38
Mohamed Sheikh Hassan, Mosab Ahmed Nor
INTRODUCTION: and Importance: Metoclopramide is a frequently used anti-emetic medication for the treatment of vomiting secondary to medical conditions or chemotherapy. Metoclopramide is known to cause extrapyramidal symptoms (drug-induced movement disorder). While the dystonic reaction is an acute condition that may emerge after a single dose of metoclopramide, Tardive dyskinesia and Parkinsonism are generally seen after prolonged use. These reactions are more frequent in patients receiving high doses of metoclopramide especially in female patients, children, and older patients...
February 2022: Annals of Medicine and Surgery
https://read.qxmd.com/read/35053647/aripiprazole-induced-oculogyric-crisis-a-pediatric-case-series-and-a-brief-narrative-review
#39
Pia Bernardo, Alfonso Rubino, Claudia Santoro, Carmela Bravaccio, Marco Pozzi, Simone Pisano
Oculogyric crisis (OGC) represent an unusual type of dystonic movement disorder, usually reported as an adverse event of antipsychotic drugs, with acute or tardive onset, likely due to a functional disruption of dopaminergic neurotransmission. It is seldom reported in children with aripiprazole, an atypical antipsychotic commonly used in youths. In this manuscript, we report on a case series of three pediatric patients and provide a brief narrative review of the literature, in order to increase the awareness of clinicians and to foster future research in this area...
December 29, 2021: Children
https://read.qxmd.com/read/35021243/-sulpiride-induced-dystonia-in-a-patient-with-tourette-syndrome-a-stroke-mimicking-presentation
#40
JOURNAL ARTICLE
Ramy Abdelnaby, Mona Ali Abosrea, Carlos Schönfeldt-Lecuona, Markus A Rudek, Mohamed Elsayed
We present a case of a 23-year-old male Caucasian patient admitted to the emergency department because of an acute onset of difficulty of articulation, weakness of the left arm, throat- and neck pain. An emergency CT & MRI of the brain showed no abnormalities. The Patient had started visiting a new neurologist three weeks before admission and received Sulpiride against Tourette syndrome (TS) in a rapid escalation manner over a short period. Sulpiride induced dystonia and other neurological symptoms that were clinically masked by dystonic and clonic tics of the known TS...
January 2022: Fortschritte der Neurologie-Psychiatrie
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