Kat Gemperli, Xinguo Lu, Keerthana Chintalapati, Alyssa Rust, Rishabh Bajpai, Nathan Suh, Joanna Blackburn, Rose Gelineau-Morel, Michael C Kruer, Dararat Mingbundersuk, Jennifer O'Malley, Laura Tochen, Jeff Waugh, Steve Wu, Timothy Feyma, Joel Perlmutter, Steven Mennerick, Jordan McCall, Bhooma R Aravamuthan
UNLABELLED: Dystonia is common, debilitating, often medically refractory, and difficult to diagnose. The gold standard for both clinical and mouse model dystonia evaluation is subjective assessment, ideally by expert consensus. However, this subjectivity makes translational quantification of clinically-relevant dystonia metrics across species nearly impossible. Many mouse models of genetic dystonias display abnormal striatal cholinergic interneuron excitation, but few display subjectively dystonic features...
July 21, 2023: bioRxiv