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https://www.readbyqxmd.com/read/28838688/evaluation-of-tetraether-lipid-based-liposomal-carriers-for-encapsulation-and-retention-of-nucleoside-based-drugs
#1
Valentina Paolucci, Geoffray Leriche, Takaoki Koyanagi, Jerry Yang
Although liposomal nanoparticles are one of the most versatile class of drug delivery systems, stable liposomal formulation of small neutral drug molecules still constitutes a challenge due to the low drug retention of current lipid membrane technologies. In this study, we evaluate the encapsulation and retention of seven nucleoside analog-based drugs in liposomes made of archaea-inspired tetraether lipids, which are known to enhance packing and membrane robustness compared to conventional bilayer-forming lipids...
September 15, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28797281/the-efficacy-of-transcutaneous-electrical-nerve-stimulation-on-the-improvement-of-walking-distance-in-patients-with-peripheral-arterial-disease-with-intermittent-claudication-study-protocol-for-a-randomised-controlled-trial-the-tens-pad-study
#2
Florent Besnier, Jean-Michel Sénard, Vincent Grémeaux, Mélanie Riédel, Damien Garrigues, Thibaut Guiraud, Marc Labrunée
BACKGROUND: In patients with peripheral arterial disease (PAD), walking improvements are often limited by early pain onset due to vascular claudication. It would thus appear interesting to develop noninvasive therapeutic strategies, such as transcutaneous electrical nerve stimulation (TENS), to improve the participation of PAD patients in rehabilitation programmes, and thus improve their quality of life. Our team recently tested the efficacy of a single 45-min session of 10-Hz TENS prior to walking...
August 10, 2017: Trials
https://www.readbyqxmd.com/read/28774270/strand-specific-transcriptomes-of-enterohemorrhagic-escherichia-coli-in-response-to-interactions-with-ground-beef-microbiota-interactions-between-microorganisms-in-raw-meat
#3
Wessam Galia, Francoise Leriche, Stéphane Cruveiller, Cindy Garnier, Vincent Navratil, Audrey Dubost, Stéphanie Blanquet-Diot, Delphine Thevenot-Sergentet
BACKGROUND: Enterohemorrhagic Escherichia coli (EHEC) are zoonotic agents associated with outbreaks worldwide. Growth of EHEC strains in ground beef could be inhibited by background microbiota that is present initially at levels greater than that of the pathogen E. coli. However, how the microbiota outcompetes the pathogenic bacteria is unknown. Our objective was to identify metabolic pathways of EHEC that were altered by natural microbiota in order to improve our understanding of the mechanisms controlling the growth and survival of EHECs in ground beef...
August 3, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28708392/thiol-triggered-release-of-intraliposomal-content-from-liposomes-made-of-extremophile-inspired-tetraether-lipids
#4
Takaoki Koyanagi, Jessica L Cifelli, Geoffray Leriche, David Onofrei, Gregory P Holland, Jerry Yang
Liposomal drug-delivery systems have been used for delivery of drugs to targeted tissues while reducing unwanted side effects. DOXIL, for instance, is a liposomal formulation of the anticancer agent doxorubicin (DOX) that has been used to address problems associated with nonspecific toxicity of free DOX. However, while this liposomal formulation allows for a more-stable circulation of doxorubicin in the body compared to free drug, the efficacy for cancer therapy is reduced in comparison with systemic injections of free drug...
August 16, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28704732/prioritizing-conservation-areas-for-coastal-plant-diversity-under-increasing-urbanization
#5
Aggeliki Doxa, Cécile Hélène Albert, Agathe Leriche, Arne Saatkamp
Coastal urban expansion will continue to drive further biodiversity losses, if conservation targets for coastal ecosystems are not defined and met. Prioritizing areas for future protected area networks is thus an urgent task in such urbanization-threatened ecosystems. Our aim is to quantify past and future losses of coastal vegetation priority areas due to urbanization and assess the effectiveness of the existing protected area network for conservation. We conduct a prioritization analysis, based on 82 coastal plants, including common and IUCN red list species, in a highly-urbanized but biotically diverse region, in South-Eastern France...
July 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28658837/leriche-syndrome-acute-onset-painful-paraplegia-of-vascular-origin-with-catastrophic-consequences
#6
Sampathkumar Mahadevappa Mahendrakar, Harpreet Singh Sandhu, Azizullah Hafizullah Khan, Yunus Shafi Loya
Acute Aorto-Iliac Occlusive Disease (AIOD) is a rare clinical entity which when presents with buttock claudication, erectile dysfunction and absent femoral pulses is termed as Leriche syndrome. A 59-year-old male patient with past history of smoking and dyslipidaemia presented with acute onset lower back pain, paraplegia, intense lower limb pain and was initially evaluated for compressive myelopathy. On further clinical examination there were absent femoral pulses and Computed Tomography (CT) aortogram was done which confirmed the diagnosis of diffuse AIOD...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28627053/recovery-of-insulin-sensitivity-and-optimal-body-composition-after-rapid-weight-loss-in-obese-dogs-fed-a-high-protein-medium-carbohydrate-diet
#7
A André, I Leriche, G Chaix, C Thorin, M Burger, P Nguyen
This study investigated the effects of an experimental high-protein medium-carbohydrate diet (protein level, 46% metabolizable energy, ME). First, postprandial plasma glucose and insulin kinetics were determined in steady-state overweight/obese Beagle dogs (28%-41% excess body weight) for an experimental high-protein medium-carbohydrate diet (protein level, 46% ME) and a commercial high-carbohydrate medium-protein diet (protein level, 24%ME) in obese dogs. Secondly, all the dogs were included in a weight loss programme...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28533115/acute-respiratory-distress-revealing-massive-pulmonary-embolism-in-a-neonate
#8
Virginie Leriche, Angelina Dubois, Guy Vaksmann
No abstract text is available yet for this article.
May 10, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28467568/-leriche-syndrome
#9
Serdar Demirgan, Abdullah Tolga Şitilci, Sezen Solak, Mehmet Salih Sevdi, Kerem Erkalp, Emin Köse
Leriche syndrome is a disease characterized by thrombotic occlusion in the aorta, frequently in the distal renal artery. Classic symptoms of this syndrome include pain in the lower extremities emerging during activity (claudication), impalpability of femoral pulses, and impotency in male patients. Definitive diagnosis of claudication due to insufficient circulation as well as claudication that is neurogenic in origin, is difficult. Medical history, physical examination, and monitoring methods are important for definitive diagnosis...
January 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/28453796/descendo-bifemoral-bypass-grafting-and-renal-artery-revascularization-to-treat-complex-obliterative-arteriopathy
#10
Stoyan Kondov, Bartosz Rylski, Fabian Alexander Kari, Rika Wobser, Simon Leschka, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
OBJECTIVES: Our goal was to describe a new standardized approach in patients with extensive obliterative arteriopathy aimed at distal revascularization and surgical kidney recruitment via descendo-bifemoral bypass grafting and renal artery revascularization. METHODS: Three patients with Leriche's syndrome and either a compromised single kidney or unilateral significant renal artery stenosis were treated with a standardized surgical approach, restoration of distal perfusion via descendo-bifemoral bypass with synchronous ( n  = 2) left-sided renal artery revascularization or metachronous ( n  = 1) right-sided renal artery revascularization...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28401281/ct-angiography-and-3d-imaging-in-aortoiliac-occlusive-disease-collateral-pathways-in-leriche-syndrome
#11
REVIEW
Sameer Ahmed, Siva P Raman, Elliot K Fishman
Collateral pathways in aortoiliac occlusive disease are essential for arterial blood flow to the abdomen, pelvis, and lower extremities. These pathways can be broadly divided into systemic-systemic, visceral-visceral, and systemic-visceral collateral networks. MDCT angiography is the most commonly used modality for the diagnostic evaluation of patients with aortoiliac occlusive disease, allowing excellent evaluation of stenotic arterial segments, as well as beautifully illustrating resulting collateral pathways (particularly when utilizing 3D reconstruction techniques)...
April 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28370726/hybrid-lipids-inspired-by-extremophiles-and-eukaryotes-afford-serum-stable-membranes-with-low-leakage
#12
Takaoki Koyanagi, Kevin J Cao, Geoffray Leriche, David Onofrei, Gregory P Holland, Michael Mayer, David Sept, Jerry Yang
This paper presents a new hybrid lipid that fuses the ideas of molecular tethering of lipid tails used by archaea and the integration of cholesterol groups used by eukaryotes, thereby leveraging two strategies employed by nature to increase lipid packing in membranes. Liposomes comprised of pure hybrid lipids exhibited a 5-30-fold decrease in membrane leakage of small ions and molecules compared to liposomes that used only one strategy (lipid tethering or cholesterol incorporation) to increase membrane integrity...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28283967/exercise-training-and-high-fat-diet-elicit-endocannabinoid-system-modifications-in-the-rat-hypothalamus-and-hippocampus
#13
François-Xavier Gamelin, Julien Aucouturier, Fabio Arturo Iannotti, Fabiana Piscitelli, Enrico Mazzarella, Teresa Aveta, Melissa Leriche, Erwan Dupont, Caroline Cieniewski-Bernard, Erwan Leclair, Bruno Bastide, Vincenzo Di Marzo, Elsa Heyman
The purpose of the present study was to examine the effect of chronic exercise on the hypothalamus and hippocampus levels of the endocannabinoids (eCBs) anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and of two AEA congeners and on the expression of genes coding for CB1, CB2 receptors (Cnr1 and Cnr2, respectively), and the enzymes responsible for eCB biosynthesis and degradation, in rats fed with a standard or high-fat diet. Male Wistar rats (n = 28) were placed on a 12-week high-fat (HFD) or standard diet period, followed by 12 weeks of exercise training for half of each group...
August 2016: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28221378/characterization-of-drug-encapsulation-and-retention-in-archaea-inspired-tetraether-liposomes
#14
Geoffray Leriche, Jessica L Cifelli, Kevin C Sibucao, Joseph P Patterson, Takaoki Koyanagi, Nathan C Gianneschi, Jerry Yang
The passive leakage of small molecules across membranes is a major limitation of liposomal drug formulations. Here, we evaluate the leakage of 3 clinically used chemotherapeutic agents (cytarabine, methotrexate and vincristine) encapsulated in liposomes comprised of a synthetic, archaea-inspired, membrane-spanning tetraether lipid. Liposomes comprised of the pure tetraether lipid exhibited superior retention of both a neutrally and positively charged drug (up to an ∼9-fold decrease in the rate of drug leakage) compared to liposomes formed from a commercial diacyl lipid, while exhibiting a similar retention of a negatively charged drug that did not appreciably leak from either type of liposome...
February 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28207276/hydrophobic-nanoparticles-reduce-the-%C3%AE-sheet-content-of-sevi-amyloid-fibrils-and-inhibit-sevi-enhanced-hiv-infectivity
#15
Daniel A Sheik, Jeffrey M Chamberlain, Lauren Brooks, Melissa Clark, Young Hun Kim, Geoffray Leriche, Clifford P Kubiak, Stephen Dewhurst, Jerry Yang
Semen-derived enhancer of virus infection (SEVI) fibrils are naturally abundant amyloid aggregates found in semen that facilitate viral attachment and internalization of human immunodeficiency virus (HIV) in cells, thereby increasing the probability of infection. Mature SEVI fibrils are composed of aggregated peptides exhibiting high β-sheet secondary structural characteristics. Herein, we show that polymers containing hydrophobic side chains can interact with SEVI and reduce its β-sheet content by ∼45% compared with the β-sheet content of SEVI in the presence of polymers with hydrophilic side chains, as estimated by polarization modulation-infrared reflectance absorption spectroscopy measurements...
March 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28122855/descendo-bifemoral-bypass-grafting-and-renal-artery-revascularization-to-treat-complex-obliterative-arteriopathy
#16
Stoyan Kondov, Bartosz Rylski, Fabian Alexander Kari, Rika Wobser, Simon Leschka, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
OBJECTIVES: Our goal was to describe a new standardized approach in patients with extensive obliterative arteriopathy aimed at distal revascularization and surgical kidney recruitment via descendo-bifemoral bypass grafting and renal artery revascularization. METHODS: Three patients with Leriche's syndrome and either a compromised single kidney or unilateral significant renal artery stenosis were treated with a standardized surgical approach, restoration of distal perfusion via descendo-bifemoral bypass with synchronous (n = 2) left-sided renal artery revascularization or metachronous (n = 1) right-sided renal artery revascularization...
January 25, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27808094/following-lithiation-fronts-in-paramagnetic-electrodes-with-in-situ-magnetic-resonance-spectroscopic-imaging
#17
Mingxue Tang, Vincent Sarou-Kanian, Philippe Melin, Jean-Bernard Leriche, Michel Ménétrier, Jean-Marie Tarascon, Michaël Deschamps, Elodie Salager
Li-ion batteries are invaluable for portable electronics and vehicle electrification. A better knowledge of compositional variations within the electrodes during battery operation is, however, still needed to keep improving their performance. Although essential in the medical field, magnetic resonance imaging of solid paramagnetic battery materials is challenging due to the short lifetime of their signals. Here we develop the scanning image-selected in situ spectroscopy approach, using the strongest commercially available magnetic field gradient...
November 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27738475/giant-perigraft-seroma-after-axillobifemoral-bypass-for-leriche-s-syndrome-a-case-report
#18
Daniele Bissacco, Maurizio Domanin, Alessandro Del Gobbo, Livio Gabrielli
Perigraft seroma is a rare complication occurs after placement of any vascular graft. It is defined as the collection of a sterile, clear and acellular liquid around prosthesis. It can appear years after surgery as a soft, palpable and painless mass. We present a perigraft seroma occurred in a 75-years-patient underwent Dacron right axillo-bifemoral bypass for Leriche's syndrome. Ultrasound and computed tomography scan revealed involvement of graft left branch and bifurcation. Although several treatment options have been proposed, removal and replacement of prosthetic affected tract with another of a different material has been proved the choice with best result...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/27650445/inflammatory-involvement-in-a-patient-with-leriche-syndrome-evaluated-by-18-f-fluorodeoxyglucose-pet-mri
#19
Atsuro Masuda, Takayoshi Yamaki, Hiroyuki Kunii, Ayaka Nemoto, Hitoshi Kubo, Hideyuki Tominaga, Noboru Oriuchi, Seiichi Takenoshita, Yasuchika Takeishi
No abstract text is available yet for this article.
September 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27578141/corrigendum-to-acute-leriche-syndrome-in-a-young-female-first-manifestation-of-atherosclerosis-j-clin-lipidol-10-2016-706-707
#20
Mihir Barvalia, Jana Mckenzie, Lilia Tcharnaia, Marc Cohen, Najam Wasty
No abstract text is available yet for this article.
July 2016: Journal of Clinical Lipidology
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