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https://www.readbyqxmd.com/read/28708392/thiol-triggered-release-of-intraliposomal-content-from-liposomes-made-of-extremophile-inspired-tetraether-lipids
#1
Takaoki Koyanagi, Jessica L Cifelli, Geoffray Leriche, David Onofrei, Gregory P Holland, Jerry Yang
Liposomal drug delivery systems have been used for delivery of drugs to targeted tissues while reducing unwanted side effects. DOXIL®, for instance, is a liposomal formulation of the anti-cancer agent doxorubicin (DOX) that has been used to address problems associated with non-specific toxicity of free DOX. However, while this liposomal formulation allows for a more stable circulation of doxorubicin in the body compared with free drug, efficacy for cancer therapy is reduced when compared with systemic injections of free drug...
July 14, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28704732/prioritizing-conservation-areas-for-coastal-plant-diversity-under-increasing-urbanization
#2
Aggeliki Doxa, Cécile Hélène Albert, Agathe Leriche, Arne Saatkamp
Coastal urban expansion will continue to drive further biodiversity losses, if conservation targets for coastal ecosystems are not defined and met. Prioritizing areas for future protected area networks is thus an urgent task in such urbanization-threatened ecosystems. Our aim is to quantify past and future losses of coastal vegetation priority areas due to urbanization and assess the effectiveness of the existing protected area network for conservation. We conduct a prioritization analysis, based on 82 coastal plants, including common and IUCN red list species, in a highly-urbanized but biotically diverse region, in South-Eastern France...
July 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28658837/leriche-syndrome-acute-onset-painful-paraplegia-of-vascular-origin-with-catastrophic-consequences
#3
Sampathkumar Mahadevappa Mahendrakar, Harpreet Singh Sandhu, Azizullah Hafizullah Khan, Yunus Shafi Loya
Acute Aorto-Iliac Occlusive Disease (AIOD) is a rare clinical entity which when presents with buttock claudication, erectile dysfunction and absent femoral pulses is termed as Leriche syndrome. A 59-year-old male patient with past history of smoking and dyslipidaemia presented with acute onset lower back pain, paraplegia, intense lower limb pain and was initially evaluated for compressive myelopathy. On further clinical examination there were absent femoral pulses and Computed Tomography (CT) aortogram was done which confirmed the diagnosis of diffuse AIOD...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28627053/recovery-of-insulin-sensitivity-and-optimal-body-composition-after-rapid-weight-loss-in-obese-dogs-fed-a-high-protein-medium-carbohydrate-diet
#4
A André, I Leriche, G Chaix, C Thorin, M Burger, P Nguyen
This study investigated the effects of an experimental high-protein medium-carbohydrate diet (protein level, 46% metabolizable energy, ME). First, postprandial plasma glucose and insulin kinetics were determined in steady-state overweight/obese Beagle dogs (28%-41% excess body weight) for an experimental high-protein medium-carbohydrate diet (protein level, 46% ME) and a commercial high-carbohydrate medium-protein diet (protein level, 24%ME) in obese dogs. Secondly, all the dogs were included in a weight loss programme...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28533115/acute-respiratory-distress-revealing-massive-pulmonary-embolism-in-a-neonate
#5
Virginie Leriche, Angelina Dubois, Guy Vaksmann
No abstract text is available yet for this article.
May 10, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28467568/-leriche-syndrome
#6
Serdar Demirgan, Abdullah Tolga Şitilci, Sezen Solak, Mehmet Salih Sevdi, Kerem Erkalp, Emin Köse
Leriche syndrome is a disease characterized by thrombotic occlusion in the aorta, frequently in the distal renal artery. Classic symptoms of this syndrome include pain in the lower extremities emerging during activity (claudication), impalpability of femoral pulses, and impotency in male patients. Definitive diagnosis of claudication due to insufficient circulation as well as claudication that is neurogenic in origin, is difficult. Medical history, physical examination, and monitoring methods are important for definitive diagnosis...
January 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/28453796/descendo-bifemoral-bypass-grafting-and-renal-artery-revascularization-to-treat-complex-obliterative-arteriopathy
#7
Stoyan Kondov, Bartosz Rylski, Fabian Alexander Kari, Rika Wobser, Simon Leschka, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
OBJECTIVES: Our goal was to describe a new standardized approach in patients with extensive obliterative arteriopathy aimed at distal revascularization and surgical kidney recruitment via descendo-bifemoral bypass grafting and renal artery revascularization. METHODS: Three patients with Leriche's syndrome and either a compromised single kidney or unilateral significant renal artery stenosis were treated with a standardized surgical approach, restoration of distal perfusion via descendo-bifemoral bypass with synchronous ( n  = 2) left-sided renal artery revascularization or metachronous ( n  = 1) right-sided renal artery revascularization...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28401281/ct-angiography-and-3d-imaging-in-aortoiliac-occlusive-disease-collateral-pathways-in-leriche-syndrome
#8
REVIEW
Sameer Ahmed, Siva P Raman, Elliot K Fishman
Collateral pathways in aortoiliac occlusive disease are essential for arterial blood flow to the abdomen, pelvis, and lower extremities. These pathways can be broadly divided into systemic-systemic, visceral-visceral, and systemic-visceral collateral networks. MDCT angiography is the most commonly used modality for the diagnostic evaluation of patients with aortoiliac occlusive disease, allowing excellent evaluation of stenotic arterial segments, as well as beautifully illustrating resulting collateral pathways (particularly when utilizing 3D reconstruction techniques)...
April 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28370726/hybrid-lipids-inspired-by-extremophiles-and-eukaryotes-afford-serum-stable-membranes-with-low-leakage
#9
Takaoki Koyanagi, Kevin J Cao, Geoffray Leriche, David Onofrei, Gregory P Holland, Michael Mayer, David Sept, Jerry Yang
This paper presents a new hybrid lipid that fuses the ideas of molecular tethering of lipid tails used by archaea and the integration of cholesterol groups used by eukaryotes, thereby leveraging two strategies employed by nature to increase lipid packing in membranes. Liposomes comprised of pure hybrid lipids exhibited a 5-30-fold decrease in membrane leakage of small ions and molecules compared to liposomes that used only one strategy (lipid tethering or cholesterol incorporation) to increase membrane integrity...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28283967/exercise-training-and-high-fat-diet-elicit-endocannabinoid-system-modifications-in-the-rat-hypothalamus-and-hippocampus
#10
François-Xavier Gamelin, Julien Aucouturier, Fabio Arturo Iannotti, Fabiana Piscitelli, Enrico Mazzarella, Teresa Aveta, Melissa Leriche, Erwan Dupont, Caroline Cieniewski-Bernard, Erwan Leclair, Bruno Bastide, Vincenzo Di Marzo, Elsa Heyman
The purpose of the present study was to examine the effect of chronic exercise on the hypothalamus and hippocampus levels of the endocannabinoids (eCBs) anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and of two AEA congeners and on the expression of genes coding for CB1, CB2 receptors (Cnr1 and Cnr2, respectively), and the enzymes responsible for eCB biosynthesis and degradation, in rats fed with a standard or high-fat diet. Male Wistar rats (n = 28) were placed on a 12-week high-fat (HFD) or standard diet period, followed by 12 weeks of exercise training for half of each group...
March 10, 2017: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28221378/characterization-of-drug-encapsulation-and-retention-in-archaea-inspired-tetraether-liposomes
#11
Geoffray Leriche, Jessica L Cifelli, Kevin C Sibucao, Joseph P Patterson, Takaoki Koyanagi, Nathan C Gianneschi, Jerry Yang
The passive leakage of small molecules across membranes is a major limitation of liposomal drug formulations. Here, we evaluate the leakage of 3 clinically used chemotherapeutic agents (cytarabine, methotrexate and vincristine) encapsulated in liposomes comprised of a synthetic, archaea-inspired, membrane-spanning tetraether lipid. Liposomes comprised of the pure tetraether lipid exhibited superior retention of both a neutrally and positively charged drug (up to an ∼9-fold decrease in the rate of drug leakage) compared to liposomes formed from a commercial diacyl lipid, while exhibiting a similar retention of a negatively charged drug that did not appreciably leak from either type of liposome...
February 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28207276/hydrophobic-nanoparticles-reduce-the-%C3%AE-sheet-content-of-sevi-amyloid-fibrils-and-inhibit-sevi-enhanced-hiv-infectivity
#12
Daniel A Sheik, Jeffrey M Chamberlain, Lauren Brooks, Melissa Clark, Young Hun Kim, Geoffray Leriche, Clifford P Kubiak, Stephen Dewhurst, Jerry Yang
Semen-derived enhancer of virus infection (SEVI) fibrils are naturally abundant amyloid aggregates found in semen that facilitate viral attachment and internalization of human immunodeficiency virus (HIV) in cells, thereby increasing the probability of infection. Mature SEVI fibrils are composed of aggregated peptides exhibiting high β-sheet secondary structural characteristics. Herein, we show that polymers containing hydrophobic side chains can interact with SEVI and reduce its β-sheet content by ∼45% compared with the β-sheet content of SEVI in the presence of polymers with hydrophilic side chains, as estimated by polarization modulation-infrared reflectance absorption spectroscopy measurements...
March 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28122855/descendo-bifemoral-bypass-grafting-and-renal-artery-revascularization-to-treat-complex-obliterative-arteriopathy
#13
Stoyan Kondov, Bartosz Rylski, Fabian Alexander Kari, Rika Wobser, Simon Leschka, Matthias Siepe, Friedhelm Beyersdorf, Martin Czerny
OBJECTIVES: Our goal was to describe a new standardized approach in patients with extensive obliterative arteriopathy aimed at distal revascularization and surgical kidney recruitment via descendo-bifemoral bypass grafting and renal artery revascularization. METHODS: Three patients with Leriche's syndrome and either a compromised single kidney or unilateral significant renal artery stenosis were treated with a standardized surgical approach, restoration of distal perfusion via descendo-bifemoral bypass with synchronous (n = 2) left-sided renal artery revascularization or metachronous (n = 1) right-sided renal artery revascularization...
January 25, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27808094/following-lithiation-fronts-in-paramagnetic-electrodes-with-in-situ-magnetic-resonance-spectroscopic-imaging
#14
Mingxue Tang, Vincent Sarou-Kanian, Philippe Melin, Jean-Bernard Leriche, Michel Ménétrier, Jean-Marie Tarascon, Michaël Deschamps, Elodie Salager
Li-ion batteries are invaluable for portable electronics and vehicle electrification. A better knowledge of compositional variations within the electrodes during battery operation is, however, still needed to keep improving their performance. Although essential in the medical field, magnetic resonance imaging of solid paramagnetic battery materials is challenging due to the short lifetime of their signals. Here we develop the scanning image-selected in situ spectroscopy approach, using the strongest commercially available magnetic field gradient...
November 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27738475/giant-perigraft-seroma-after-axillobifemoral-bypass-for-leriche-s-syndrome-a-case-report
#15
Daniele Bissacco, Maurizio Domanin, Alessandro Del Gobbo, Livio Gabrielli
Perigraft seroma is a rare complication occurs after placement of any vascular graft. It is defined as the collection of a sterile, clear and acellular liquid around prosthesis. It can appear years after surgery as a soft, palpable and painless mass. We present a perigraft seroma occurred in a 75-years-patient underwent Dacron right axillo-bifemoral bypass for Leriche's syndrome. Ultrasound and computed tomography scan revealed involvement of graft left branch and bifurcation. Although several treatment options have been proposed, removal and replacement of prosthetic affected tract with another of a different material has been proved the choice with best result...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/27650445/inflammatory-involvement-in-a-patient-with-leriche-syndrome-evaluated-by-18-f-fluorodeoxyglucose-pet-mri
#16
Atsuro Masuda, Takayoshi Yamaki, Hiroyuki Kunii, Ayaka Nemoto, Hitoshi Kubo, Hideyuki Tominaga, Noboru Oriuchi, Seiichi Takenoshita, Yasuchika Takeishi
No abstract text is available yet for this article.
September 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27578141/corrigendum-to-acute-leriche-syndrome-in-a-young-female-first-manifestation-of-atherosclerosis-j-clin-lipidol-10-2016-706-707
#17
Mihir Barvalia, Jana Mckenzie, Lilia Tcharnaia, Marc Cohen, Najam Wasty
No abstract text is available yet for this article.
July 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27533468/synergistic-effects-of-eif4a-and-mek-inhibitors-on-proliferation-of-nras-mutant-melanoma-cell-lines
#18
Hélène Malka-Mahieu, Isabelle Girault, Margot Rubington, Melissa Leriche, Caroline Welsch, Nyam Kamsu-Kom, Qian Zhao, Laurent Desaubry, Stéphan Vagner, Caroline Robert
Activating mutations of the NRAS (neuroblastoma rat sarcoma viral oncogene) protein kinase, present in many cancers, induce a constitutive activation of both the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway and the PI(3)K-AKT-mTOR, pathway. This in turn regulates the formation of the eIF4F eukaryotic translation initiation complex, comprising the eIF4E cap-binding protein, the eIF4G scaffolding protein and the eIF4A RNA helicase, which binds to the 7-methylguanylate cap (m(7)G) at the 5' end of messenger RNAs...
September 16, 2016: Cell Cycle
https://www.readbyqxmd.com/read/27467856/laparoscopy-in-the-surgical-treatment-of-disorders-of-sexual-development
#19
Christine Burgmeier, Clothilde Leriche
INTRODUCTION: Disorder of sexual development (DSD) is a rare condition. The surgical treatment of these patients includes investigation of the internal genitalia, evaluation of the gonads, and if necessary gonadectomy. The prevention of germ cell tumors is the most important issue in the surgical treatment of this varied and special group of patients. This study aimed to evaluate the role of laparoscopy in the surgical treatment of patients with DSD. MATERIALS AND METHODS: Over a 4-year-period, all patients presenting with DSD who underwent laparoscopic surgery at our institution were retrospectively reviewed...
September 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27429202/increased-ehec-survival-and-virulence-gene-expression-indicate-an-enhanced-pathogenicity-upon-simulated-pediatric-gastrointestinal-conditions
#20
Charlène Roussel, Charlotte Cordonnier, Wessam Galia, Olivier Le Goff, Jonathan Thévenot, Sandrine Chalancon, Monique Alric, Delphine Thevenot-Sergentet, Francoise Leriche, Tom Van de Wiele, Valérie Livrelli, Stéphanie Blanquet-Diot
BackgroundEnterohemorrhagic Escherichia coli (EHEC) are major foodborne pathogens that constitute a serious public health threat, mainly in young children. Shiga toxins (Stx) are the main virulence determinants of EHEC pathogenesis but adhesins like intimin (eae) and Long polar fimbriae (Lpf) also contribute to infection. The TNO GastroIntestinal tract Model (TIM) was used for a comparative study of EHEC O157:H7 survival and virulence under adult and child digestive conditions.MethodsSurvival kinetics in the in vitro digestive tract were determined by plating while bacterial viability was assessed by flow cytometry analysis...
July 18, 2016: Pediatric Research
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