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Bissacco Daniele, Domanin Maurizio, Del Gobbo Alessandro, Gabrielli Livio
Perigraft seroma is a rare complication occurs after placement of any vascular graft. It is defined as the collection of a sterile, clear and acellular liquid around prosthesis. It can appear years after surgery as a soft, palpable and painless mass. We present a perigraft seroma occurred in a 75-years-patient underwent Dacron right axillo-bifemoral bypass for Leriche's syndrome. Ultrasound and computed tomography scan revealed involvement of graft left branch and bifurcation. Although several treatment options have been proposed, removal and replacement of prosthetic affected tract with another of a different material has been proved the choice with best result...
2016: Annals of Vascular Diseases
Atsuro Masuda, Takayoshi Yamaki, Hiroyuki Kunii, Ayaka Nemoto, Hitoshi Kubo, Hideyuki Tominaga, Noboru Oriuchi, Seiichi Takenoshita, Yasuchika Takeishi
No abstract text is available yet for this article.
September 20, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Mihir Barvalia, Jana Mckenzie, Lilia Tcharnaia, Marc Cohen, Najam Wasty
No abstract text is available yet for this article.
July 2016: Journal of Clinical Lipidology
Hélène Malka-Mahieu, Isabelle Girault, Margot Rubington, Melissa Leriche, Caroline Welsch, Nyam Kamsu-Kom, Qian Zhao, Laurent Desaubry, Stéphan Vagner, Caroline Robert
Activating mutations of the NRAS (neuroblastoma rat sarcoma viral oncogene) protein kinase, present in many cancers, induce a constitutive activation of both the RAS-RAF-MEK-ERK mitogen-activated protein kinase (MAPK) signal transduction pathway and the PI(3)K-AKT-mTOR, pathway. This in turn regulates the formation of the eIF4F eukaryotic translation initiation complex, comprising the eIF4E cap-binding protein, the eIF4G scaffolding protein and the eIF4A RNA helicase, which binds to the 7-methylguanylate cap (m(7)G) at the 5' end of messenger RNAs...
September 16, 2016: Cell Cycle
Christine Burgmeier, Clothilde Leriche
INTRODUCTION: Disorder of sexual development (DSD) is a rare condition. The surgical treatment of these patients includes investigation of the internal genitalia, evaluation of the gonads, and if necessary gonadectomy. The prevention of germ cell tumors is the most important issue in the surgical treatment of this varied and special group of patients. This study aimed to evaluate the role of laparoscopy in the surgical treatment of patients with DSD. MATERIALS AND METHODS: Over a 4-year-period, all patients presenting with DSD who underwent laparoscopic surgery at our institution were retrospectively reviewed...
September 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Charlène Roussel, Charlotte Cordonnier, Wessam Galia, Olivier Le Goff, Jonathan Thévenot, Sandrine Chalancon, Monique Alric, Delphine Thevenot-Sergentet, Francoise Leriche, Tom Van de Wiele, Valérie Livrelli, Stéphanie Blanquet-Diot
BackgroundEnterohemorrhagic Escherichia coli (EHEC) are major foodborne pathogens that constitute a serious public health threat, mainly in young children. Shiga toxins (Stx) are the main virulence determinants of EHEC pathogenesis but adhesins like intimin (eae) and Long polar fimbriae (Lpf) also contribute to infection. The TNO GastroIntestinal tract Model (TIM) was used for a comparative study of EHEC O157:H7 survival and virulence under adult and child digestive conditions.MethodsSurvival kinetics in the in vitro digestive tract were determined by plating while bacterial viability was assessed by flow cytometry analysis...
July 18, 2016: Pediatric Research
Carlos A Hinojosa, Javier E Anaya-Ayala, Hugo Laparra-Escareno, Rene Lizola, Adriana Torres-Machorro
The aortic bifurcation and iliac vessels are common sites of atherosclerotic occlusive disease causing the clinical expression known as "Leriche's syndrome". An aortobifemoral bypass grafting in the setting of a septic groin remains a significant challenge to vascular surgeons. We present a 65-year-old male with complete occlusion of the distal aorta and iliac arteries; he had undergone a left axillo-femoral and femoral-femoral artery bypass 2 years prior to our evaluation. Owing to a complex graft infection in the right groin and worsening lower extremity ischemia, we performed an aortobifemoral reconstruction through the right obturator membrane...
June 2016: Vascular Specialist International
Thomas B H Schroeder, Geoffray Leriche, Takaoki Koyanagi, Mitchell A Johnson, Kathryn N Haengel, Olivia M Eggenberger, Claire L Wang, Young Hun Kim, Karthik Diraviyam, David Sept, Jerry Yang, Michael Mayer
This work explores the proton/hydroxide permeability (PH+/OH-) of membranes that were made of synthetic extremophile-inspired phospholipids with systematically varied structural elements. A fluorescence-based permeability assay was optimized to determine the effects on the PH+/OH- through liposome membranes with variations in the following lipid attributes: transmembrane tethering, tether length, and the presence of isoprenoid methyl groups on one or both lipid tails. All permeability assays were performed in the presence of a low concentration of valinomycin (10 nM) to prevent buildup of a membrane potential without artificially increasing the measured PH+/OH-...
June 7, 2016: Biophysical Journal
H L Codjo, T A Adoukonou, A Wanvoegbe, H Dohou, C Bankolé, A Alassani, C A Dovonou, D M Houénassi
We aimed to determine the prevalence of peripheral artery disease and its associated factors among diabetics. The cross-sectional study was conducted and included all diabetics admitted to the diabetic clinic at the Parakou University hospital during the period of 1st February and 31st July 2013. The diagnosis of peripheral artery disease was based on the Ankle Brachial Index (ABI)<0.9. The socio-demographics data, the data concerning the diabetes and its complications were recorded in each patient. They were 401 diabetics and 59...
September 2016: Annales de Cardiologie et D'angéiologie
Anand Singla, Darshanjeet Singh Walia, Rishabhpreet Kaur
Gastric outlet obstruction in adults is usually caused by pyloric stenosis secondary to peptic ulcer disease or malignancy. However, there are few other causes such as a foreign body and external compression due to pseudocyst pancreas. We present a rare aetiology of a large collection of pus in the lesser sac in our patient causing gastric outlet obstruction. A perforated peptic ulcer was suspected in our patient who had symptoms of sudden onset pain in epigastric region which was referred to back. This was followed by pain in upper abdomen, vomiting, constipation and fever for which patient was being managed conservatively before being referred to us...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
Sylvain A Jacques, Geoffray Leriche, Michel Mosser, Marc Nothisen, Christian D Muller, Jean-Serge Remy, Alain Wagner
pH-Sensitive linkers designed to undergo selective hydrolysis at acidic pH compared to physiological pH can be used for the selective release of therapeutics at their site of action. In this paper, the hydrolytic cleavage of a wide variety of molecular structures that have been reported for their use in pH-sensitive delivery systems was examined. A wide variety of hydrolytic stability profiles were found among the panel of tested chemical functionalities. Even within a structural family, a slight modification of the substitution pattern has an unsuspected outcome on the hydrolysis stability...
June 7, 2016: Organic & Biomolecular Chemistry
Takaoki Koyanagi, Geoffray Leriche, Alvin Yep, David Onofrei, Gregory P Holland, Michael Mayer, Jerry Yang
This paper examines the effects of four different polar headgroups on small-ion membrane permeability from liposomes comprised of Archaea-inspired glycerolmonoalkyl glycerol tetraether (GMGT) lipids. We found that the membrane-leakage rate across GMGT lipid membranes varied by a factor of ≤1.6 as a function of headgroup structure. However, the leakage rates of small ions across membranes comprised of commercial bilayer-forming 1-palmitoyl-2-oleoyl-sn-glycerol (PO) lipids varied by as much as 32-fold within the same series of headgroups...
June 6, 2016: Chemistry: a European Journal
M S Bhatia, Priyanka Gautam, Rashmita Saha
Leriche syndrome results from thrombotic occlusion of the abdominal aorta immediately above the site of its bifurcation. Impotence in leriche syndrome is caused due to proximal obstruction, commonly involving isolated common iliac, internal iliac, internal pudendal or dorsalis penis artery. The symptoms of Leriche syndrome include intermittent and bilateral claudication, pallor, coldness and fatigue in lower extremities. Data regarding psychiatric morbidity in Leriche syndrome is unavailable. We hereby report the case of Leriche syndrome, presenting to psychiatry outpatient department with depressive disorder and erectile dysfunction (ED) with focus on dilemmas faced in the diagnosis and management in psychiatry...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
A N Vachev, V V Sukhorukov, O V Dmitriev, A V Krugomov
Presented in the article are the results of treating a total of 108 patients with chronic critical lower limb ischaemia (CCLLI) confirmed according to the recommendations of the Transatlantic Inter-Society Consensus (TASC) 2007 [1]. All patients were diagnosed as having combined lesions of the aortoiliac and femoropopliteal segments of the arterial bed of the lower limbs. All patients underwent simultaneous hybrid operations: open reconstructive interventions in the infrarenal zone and stenting of iliac arteries...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
Georges Kalouche, Fanny Beguier, Michael Bakria, Stéphane Melik-Parsadaniantz, Caroline Leriche, Thomas Debeir, William Rostène, Christophe Baudouin, Xavier Vigé
PURPOSE: Prostaglandin F2α analogues are the first-line medication for the treatment of ocular hypertension (OHT), and prostanoid EP2 receptor agonists are under clinical development for this indication. The goal of this study was to investigate the effects of F prostanoid (FP) and EP2 receptor activation on the myofibroblast transition of primary trabecular meshwork (TM) cells, which could be a causal mechanism of TM dysfunction in glaucoma. METHODS: Human primary TM cells were treated with either latanoprost or butaprost and TGF-β2...
April 2016: Investigative Ophthalmology & Visual Science
Bogdan Ioncioaia, Ioan Teodor Bud, Mircea Muresan
René Leriche (1879-1955) was a 20(th) century French surgeon generally known in medicine for the syndrome that carries his name, namely the Leriche syndrome in the aorto-iliac occlusive disease. This paper is published to mark the commemoration of 60 year since Leriche's death. Although Dr. Leriche's legacy resides in the domain of vascular medicine, his research enclosed bone pathology and surgical management of pain. Having his surgical training done under professors Mathieu Jaboulay and Antonin Poncet, his friendship and association with Alexis Carrel and William Halsted have contributed to René Leriche's development as a surgeon, researcher and thinker...
2016: Clujul Medical (1957)
François Baert, Clément Cabanetos, Magali Allain, Virginie Silvestre, Philippe Leriche, Philippe Blanchard
Small push-pull molecules were synthesized in high yields by connecting a N-methyl or N-phenyl substituted thieno[2,3-b]indole electron-donating block directly to a 2,2-dicyanovinyl or (1-(dicyanomethylene)-3-oxo-1-inden-2-ylidene)methyl electron-withdrawing group. The effects of the N-substitution on thieno[2,3-b]indole and the nature of the electron-accepting group on the electrochemical, optical, and charge-transport properties were investigated by cyclic voltammetry, UV-vis spectroscopy, and the space-charge-limited current method, respectively...
April 1, 2016: Organic Letters
François-Xavier Gamelin, Julien Aucouturier, Fabio Arturo Iannotti, Fabiana Piscitelli, Enrico Mazzarella, Teresa Aveta, Melissa Leriche, Erwan Dupont, Caroline Cieniewski-Bernard, Valérie Montel, Bruno Bastide, Vincenzo Di Marzo, Elsa Heyman
The endocannabinoid system is dysregulated during obesity in tissues involved in the control of food intake and energy metabolism. We examined the effect of chronic exercise on the tissue levels of endocannabinoids (eCBs) and on the expression of genes coding for cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2) (Cnr1 and Cnr2, respectively) in the subcutaneous (SAT) and visceral adipose tissues and in the soleus and extensor digitorim longus (EDL) muscles, in rats fed with standard or high-fat diet...
June 2016: Journal of Physiology and Biochemistry
Nassim Djebli, Sonia Khier, Florence Griguer, Anne-Laure Coutant, Alexandra Tavernier, Gerard Fabre, Caroline Leriche, David Fabre
BACKGROUND AND OBJECTIVE: When eye diseases are treated by topical administration, the success of treatment lies in the effective drug concentration in the target tissue. This is why the drug's pharmacokinetic, in the different substructures of the eye, needs to be explored more accurately during drug development. The aim of the present analysis was to describe by rabbit model, the distribution of a drug after ocular instillation in the selected eye tissues and fluids. METHODS: By a top-down population approach, we developed and validated a population pharmacokinetics (PopPK) model, using tissue concentrations (tear, naso-lacrymal duct, cornea and aqueous humor) of a new src tyrosine kinase inhibitor (FV-60165) in each anterior segment's tissue and fluid of the rabbit eye...
January 28, 2016: European Journal of Drug Metabolism and Pharmacokinetics
Chiara Pranteda, Danilo Menna, Laura Capoccia, Pasqualino Sirignano, Wassim Mansour, Francesco Speziale
The coral reef aorta (CRA) is a rare syndrome commonly referred to a distribution of calcified plaques in the visceral part of the aorta. Because those plaques can cause malperfusion of the lower limbs, visceral ischemia or renovascular hypertension, surgical treatment is recommended. Transaortic endarterectomy is accepted as a standard repair and it is often performed through an extensive thoracoabdominal approach. CRA has been reported in association with polidistrectual atherosclerotic disease, such as Leriche syndrome...
April 2016: Annals of Vascular Surgery
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