keyword
MENU ▼
Read by QxMD icon Read
search

Transient global

keyword
https://www.readbyqxmd.com/read/29768412/adverse-events-following-single-dose-treatment-of-lymphatic-filariasis-observations-from-a-review-of-the-literature
#1
Philip J Budge, Carly Herbert, Britt Andersen, Gary J Weil
BACKGROUND: WHO's Global Programme to Eliminate Lymphatic Filariasis (LF) uses mass drug administration (MDA) of anthelmintic medications to interrupt LF transmission in endemic areas. Recently, a single dose combination of ivermectin (IVM), diethylcarbamazine (DEC), and albendazole (ALB) was shown to be markedly more effective than the standard two-drug regimens (DEC or IVM, plus ALB) for achieving long-term clearance of microfilaremia. OBJECTIVE AND METHODS: To provide context for the results of a large-scale, international safety trial of MDA using triple drug therapy, we searched Ovid Medline for studies published from 1985-2017 that reported adverse events (AEs) following treatment of LF with IVM, DEC, ALB, or any combination of these medications...
May 16, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29763986/early-iv-injected-human-dermis-derived-mesenchymal-stem-cells-after-transient-global-cerebral-ischemia-do-not-pass-through-damaged-blood-brain-barrier
#2
Ji Hyeon Ahn, Bai Hui Chen, Joon Ha Park, Bich Na Shin, Tae-Kyeong Lee, Jeong Hwi Cho, Jae Chul Lee, Jeong-Ran Park, Se-Ran Yang, Sungwoo Ryoo, Myoung Cheol Shin, Jun Hwi Cho, Il Jun Kang, Choong Hyun Lee, In Koo Hwang, Young-Myeong Kim, Moo-Ho Won
There is lack of researches on effects of intravenously injected mesenchymal stem cells (MSCs) against transient cerebral ischemia (TCI). We investigated the disruption of the neurovascular unit (NVU), which comprises the blood-brain barrier (BBB) and examined entry of human dermis-derived MSCs (hDMSCs) into the damaged hippocampal CA1 area in a gerbil model of TCI, and their subsequent effects on neuroprotection and cognitive function. Impairments of neurons, and BBB were examined by immunohistochemistry, electron microscopy, and Evans blue and immunoglobulin G (IgG) leakage...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29760332/dry-thermotropic-glycolipid-self-assembly-a-review
#3
Rauzah Hashim, N Idayu Zahid, T S Velayutham, Nurul Fadhilah Kamalul Aripin, Shigesaburo Ogawa, Akihiko Sugimura
Also recognized as carbohydrate liquid crystals, glycolipids are amphiphiles whose basic unit comprises of a sugar group attached to an alkyl chain. Glycolipids are amphitropic, which means these materials form liquid crystal self-assemblies when dry (thermotropic) as well as when dissolved in solvents (lyotropic/surfactants) such as water. Many glycolipids are also naturally derived since these can be found in cell membranes. Their membrane and surfactant functions are largely understood through their lyotropic properties...
May 15, 2018: Journal of Oleo Science
https://www.readbyqxmd.com/read/29760102/broad-receptor-engagement-of-an-emerging-global-coronavirus-may-potentiate-its-diverse-cross-species-transmissibility
#4
Wentao Li, Ruben J G Hulswit, Scott P Kenney, Ivy Widjaja, Kwonil Jung, Moyasar A Alhamo, Brenda van Dieren, Frank J M van Kuppeveld, Linda J Saif, Berend-Jan Bosch
Porcine deltacoronavirus (PDCoV), identified in 2012, is a common enteropathogen of swine with worldwide distribution. The source and evolutionary history of this virus is, however, unknown. PDCoV belongs to the Deltacoronavirus genus that comprises predominantly avian CoV. Phylogenetic analysis suggests that PDCoV originated relatively recently from a host-switching event between birds and mammals. Insight into receptor engagement by PDCoV may shed light into such an exceptional phenomenon. Here we report that PDCoV employs host aminopeptidase N (APN) as an entry receptor and interacts with APN via domain B of its spike (S) protein...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29758716/topological-resilience-in-non-normal-networked-systems
#5
Malbor Asllani, Timoteo Carletti
The network of interactions in complex systems strongly influences their resilience and the system capability to resist external perturbations or structural damages and to promptly recover thereafter. The phenomenon manifests itself in different domains, e.g., parasitic species invasion in ecosystems or cascade failures in human-made networks. Understanding the topological features of the networks that affect the resilience phenomenon remains a challenging goal for the design of robust complex systems. We hereby introduce the concept of non-normal networks, namely networks whose adjacency matrices are non-normal, propose a generating model, and show that such a feature can drastically change the global dynamics through an amplification of the system response to exogenous disturbances and eventually impact the system resilience...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29757741/saliency-detection-via-absorbing-markov-chain-with-learnt-transition-probability
#6
Lihe Zhang, Jianwu Ai, Bowen Jiang, Huchuan Lu, Xiukui Li
In this paper, we propose a bottom-up saliency model based on absorbing Markov chain (AMC). First, a sparsely connected graph is constructed to capture the local context information of each node. All image boundary nodes and other nodes are, respectively, treated as the absorbing nodes and transient nodes in the absorbing Markov chain. Then, the expected number of times from each transient node to all other transient nodes can be used to represent the saliency value of this node. The absorbed time depends on the weights on the path and their spatial coordinates, which are completely encoded in the transition probability matrix...
February 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29752180/-177-lu-psma-617-radionuclide-treatment-in-patients-with-metastatic-castration-resistant-prostate-cancer-lupsma-trial-a-single-centre-single-arm-phase-2-study
#7
Michael S Hofman, John Violet, Rodney J Hicks, Justin Ferdinandus, Sue Ping Thang, Tim Akhurst, Amir Iravani, Grace Kong, Aravind Ravi Kumar, Declan G Murphy, Peter Eu, Price Jackson, Mark Scalzo, Scott G Williams, Shahneen Sandhu
BACKGROUND: Progressive metastatic castration-resistant prostate cancer is a highly lethal disorder and new effective therapeutic agents that improve patient outcomes are urgently needed. Lutetium-177 [177 Lu]-PSMA-617, a radiolabelled small molecule, binds with high affinity to prostate-specific membrane antigen (PSMA) enabling beta particle therapy targeted to metastatic castration-resistant prostate cancer. We aimed to investigate the safety, efficacy, and effect on quality of life of [177 Lu]-PSMA-617 in men with metastatic castration-resistant prostate cancer who progressed after standard treatments...
May 7, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29748646/the-effect-of-the-total-small-vessel-disease-burden-on-the-structural-brain-network
#8
Xiaopei Xu, Kui Kai Lau, Yuen Kwun Wong, Henry K F Mak, Edward S Hui
Different cerebral small vessel disease (SVD) lesion types have been shown to disrupt structural brain network individually. Considering that they often coexist, we investigated the relation between their collective effect using the recently proposed total SVD score and structural brain network on MRI in 95 patients with first transient ischemic attack (TIA) or ischemic stroke. Fifty-nine patients with and 36 without any SVD lesions were included. The total SVD score was recorded. Diffusion tensor imaging was performed to estimate structural brain connections for subsequent brain connectivity analysis...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29744785/herb-induced-liver-injury-a-global-concern
#9
Neil Kaplowitz
Chinese medicine and herb medicine though used to treat liver diseases are an important cause of liver injury. Many phytochemicals have the potential to injure the liver, some in a dose-related fashion and more often in an idiosyncratic fashion, meaning occurrence is uncommon to rare in the population using these treatments. As is the case with pharmaceuticals, the phytochemicals are usually tolerated despite either no or mild transient subclinical injury but rarely in some susceptible patients cause moderate to severe liver injury which is likely mediated by the adaptive immune system...
May 3, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29743503/qsr-a-quantitative-super-resolution-analysis-tool-reveals-the-cell-cycle-dependent-organization-of-rna-polymerase-i-in-live-human-cells
#10
J O Andrews, W Conway, W -K Cho, A Narayanan, J -H Spille, N Jayanth, T Inoue, S Mullen, J Thaler, I I Cissé
We present qSR, an analytical tool for the quantitative analysis of single molecule based super-resolution data. The software is created as an open-source platform integrating multiple algorithms for rigorous spatial and temporal characterizations of protein clusters in super-resolution data of living cells. First, we illustrate qSR using a sample live cell data of RNA Polymerase II (Pol II) as an example of highly dynamic sub-diffractive clusters. Then we utilize qSR to investigate the organization and dynamics of endogenous RNA Polymerase I (Pol I) in live human cells, throughout the cell cycle...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29732402/the-local-microenvironment-limits-the-regenerative-potential-of-the-mouse-neonatal-heart
#11
Mario Notari, Antoni Ventura-Rubio, Sylvia J Bedford-Guaus, Ignasi Jorba, Lola Mulero, Daniel Navajas, Mercè Martí, Ángel Raya
Neonatal mice have been shown to regenerate their hearts during a transient window of time of approximately 1 week after birth. However, experimental evidence for this phenomenon is not undisputed, because several laboratories have been unable to detect neonatal heart regeneration. We first confirmed that 1-day-old neonatal mice are indeed able to mount a robust regenerative response after heart amputation. We then found that this regenerative ability sharply declines within 48 hours, with hearts of 2-day-old mice responding to amputation with fibrosis, rather than regeneration...
May 2018: Science Advances
https://www.readbyqxmd.com/read/29731679/black-rice-oryza-sativa-l-poaceae-extract-reduces-hippocampal-neuronal-cell-death-induced-by-transient-global-cerebral-ischemia-in-mice
#12
Sun-Nyoung Hwang, Jae-Cheon Kim, Mohammad Iqbal Hossain Bhuiyan, Joo Youn Kim, Ji Seon Yang, Shin Hee Yoon, Kee Dong Yoon, Seong Yun Kim
Rice is the most commonly consumed grain in the world. Black rice has been suggested to contain various bioactive compounds including anthocyanin antioxidants. There is currently little information about the nutritional benefits of black rice on brain pathology. Here, we investigated the effects of black rice ( Oryza sativa L ., Poaceae) extract (BRE) on the hippocampal neuronal damage induced by ischemic insult. BRE (300 mg/kg) was orally administered to adult male C57BL/6 mice once a day for 21 days. Bilateral common carotid artery occlusion (BCCAO) was performed for 23 min on the 8th day of BRE or vehicle administration...
April 2018: Experimental Neurobiology
https://www.readbyqxmd.com/read/29720346/tako-tsubo-cardiomyopathy-with-transient-global-amnesia-and-cerebellar-embolic-stroke-triggered-by-existential-fear
#13
Claudia Stöllberger, Nicolas DeCillia, Josef Finsterer
BACKGROUND: Embolic stroke is a complication of Tako-Tsubo-cardiomyopathy (TTC), transient left ventricular dysfunction mimicking myocardial infarction without coronary culprit lesion explaining the whole left ventricular dysfunction. Transient global amnesia (TGA) is characterized by sudden onset of anterograde amnesia without compromise of other neurologic functions. CASE REPORT: A 57 years old female was admitted because of sudden confusion and loss of her memory after emotional stress...
January 6, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29719166/paleobotany-and-global-change-important-lessons-for-species-to-biomes-from-vegetation-responses-to-past-global-change
#14
Jennifer C McElwain
Human carbon use during the next century will lead to atmospheric carbon dioxide concentrations (pCO2 ) that have been unprecedented for the past 50-100+ million years according to fossil plant-based CO2 estimates. The paleobotanical record of plants offers key insights into vegetation responses to past global change, including suitable analogs for Earth's climatic future. Past global warming events have resulted in transient poleward migration at rates that are equivalent to the lowest climate velocities required for current taxa to keep pace with climate change...
April 29, 2018: Annual Review of Plant Biology
https://www.readbyqxmd.com/read/29718359/how-cervical-reconstruction-surgery-affects-global-spinal-alignment
#15
Jun Mizutani, Russell Strom, Kuniyoshi Abumi, Kenji Endo, Ken Ishii, Mitsuru Yagi, Bobby Tay, Vedat Deviren, Christopher Ames
BACKGROUND: There have been no reports describing how cervical reconstruction surgery affects global spinal alignment (GSA). OBJECTIVE: To elucidate the effects of cervical reconstruction for GSA through a retrospective multicenter study. METHODS: Seventy-eight patients who underwent cervical reconstruction surgery for cervical kyphosis were divided into a Head-balanced group (n = 42) and a Trunk-balanced group (n = 36) according to the values of the C7 plumb line (PL)...
April 28, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29717977/a-study-of-novel-bilateral-thermal-capsulotomy-with-focused-ultrasound-for-treatment-refractory-obsessive-compulsive-disorder-2-year-follow-up
#16
Se Joo Kim, Daeyoung Roh, Hyun Ho Jung, Won Seok Chang, Chan-Hyung Kim, Jin Woo Chang
BACKGROUND: Recently, a new thermal lesioning approach using magnetic-resonance-guided focused ultrasound (MRgFUS) was introduced for the treatment of neurologic disorders. However, only 2 studies have used this approach for treatment-refractory obsessive-compulsive disorder (OCD), and follow-up was short-term. We investigated the efficacy and safety of bilateral thermal lesioning of the anterior limb of the internal capsule using MRgFUS in patients with treatment-refractory OCD and followed them for 2 years...
May 2, 2018: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29713638/omeprazole-minimally-alters-the-fecal-microbial-community-in-six-cats-a-pilot-study
#17
Sarah M Schmid, Jan S Suchodolski, Josh M Price, M K Tolbert
Although they have historically been thought of as safe medications, proton pump inhibitors such as omeprazole have been associated with an increased risk of enteric, particularly Clostridium difficile , infections in people. In cats, omeprazole is often the first choice acid suppressant prescribed for the treatment of upper gastrointestinal (GI) ulceration and bleeding. Despite this, no studies to date have explored the effect of omeprazole on the feline fecal microbiome and metabolome. Therefore, the purpose of this pilot study was to evaluate the effect of prolonged omeprazole administration on the fecal microbiome and metabolome in healthy cats to identify targets for analysis in a larger subset of cats with GI disease...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29709925/relationship-between-cytotoxicity-in-the-hippocampus-and-an-abnormal-high-intensity-area-on-the-diffusion-weighted-images-of-three-patients-with-transient-global-amnesia
#18
Katsuhiko Ogawa, Yutaka Suzuki, Takayoshi Akimoto, Keiji Shiobara, Makoto Hara, Akihiko Morita, Satoshi Kamei, Masayoshi Soma
Objective An abnormal high intensity area (HIA) on diffusion-weighted imaging (DWI) indicates the presence of cytotoxic edema and has been reported to be observed in the hippocampus of patients with transient global amnesia (TGA). The appearance of an HIA on DWI is usually delayed after the onset of patients with amnesia in TGA; thus, the significance of the HIA was evaluated in patients with TGA. Patients and Methods Three adult TGA patients who had a unilateral HIA on DWI (right, n=2; left, n=1) were enrolled...
April 27, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29704256/multi-objective-optimization-of-managed-aquifer-recharge
#19
Aybulat Fatkhutdinov, Catalin Stefan
This study demonstrates the utilization of a multi-objective hybrid global/local optimization algorithm for solving managed aquifer recharge (MAR) design problems, in which the decision variables included spatial arrangement of water injection and abstraction wells and time-variant rates of pumping and injection. The objective of the optimization was to maximize the efficiency of the MAR scheme, which includes both quantitative and qualitative aspects. The case study used to demonstrate the capabilities of the proposed approach is based on a published report on designing a real MAR site with defined aquifer properties, chemical groundwater characteristics as well as quality and volumes of injected water...
April 27, 2018: Ground Water
https://www.readbyqxmd.com/read/29702163/transient-global-cerebral-ischemia-differentially-affects-cortex-striatum-and-hippocampus-in-bilateral-common-carotid-arterial-occlusion-bccao-mouse-model
#20
Abhipradnya Bipin Wahul, Pranav Chintamani Joshi, Arvind Kumar, Sumana Chakravarty
Despite the advancements in medical sciences in last few decades, we are yet to develop promising therapeutics for stroke, which is one of the current global non-communicative disease concerns. The occurrence of stroke is likely to increase further due to the transition in our lifestyles. Inadequate knowledge of the sequential region-specific pathological events induced by cerebral ischemia is one of the underlying reasons. Hence to address this, we have used Bilateral Common Carotid Arterial occlusion (BCCAo) model that mimics human cardiac arrest condition...
April 24, 2018: Journal of Chemical Neuroanatomy
keyword
keyword
34334
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"