Irene G Wong, Jillian Stark, VanNashlee Ya, Aaron L Moye, Alan Baez Vazquez, Susanna M Dang, Andrea Shehaj, Maral J Rouhani, Roderick Bronson, Sam M Janes, Samuel P Rowbotham, Margherita Paschini, Ruth A Franklin, Carla F Kim
UNLABELLED: Acute injury in the airways or the lung activates local progenitors and stimulates changes in cell-cell interactions to restore homeostasis, but it is not appreciated how more distant niches are impacted. We utilized mouse models of airway-specific epithelial injury to examine secondary tissue-wide alveolar, immune, and mesenchymal responses. Single-cell transcriptomics and in vivo validation revealed transient, tissue-wide proliferation of alveolar type 2 (AT2) progenitor cells after club cell-specific ablation...
April 3, 2024: bioRxiv