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https://www.readbyqxmd.com/read/29334646/17%C3%AE-estradiol-improves-the-efficacy-of-exploited-autologous-bone-marrow-derived-mesenchymal-stem-cells-in-non-union-radial-defect-healing-a-rabbit-model
#1
Delaram Zamani Mazdeh, Pezhman Mirshokraei, Mohammadreza Emami, Ali Mirshahi, Iraj Karimi
Exploiting mesenchymal stem cells (MSCs) appears to be an appealing alternative to the traditional clinical approach in the treatment of non-union bone defects. It has been shown that 17β-estradiol improves the osteogenesis and proliferation potential of the MSCs via estrogen receptors. We investigated the effect of 17β-estradiol on exploiting autologous BMSCs (bone marrow-derived MSCs) for the purpose of healing of radial non-union segmental defect in rabbit. Twenty rabbits were divided into 4 experimental groups: 1...
December 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29326767/internal-fixation-of-only-the-distal-end-in-a-bipolar-segmental-clavicle-fracture-a-case-report
#2
T Ogawa, T Sasaki, M K Masayuki-Kawashima, A Okawa, M K Mahito-Kawashima
Bipolar segmental clavicle fractures are simultaneous clavicle fractures of both proximal and distal ends. Few case reports describing these fractures have been published, and the management of these injuries have remained controversial. Non-operative treatment is likely to result in poor shoulder function due to the instability of the fracture in patients with high physical demands. In contrast, surgical treatment with fixation of both proximal and distal ends of the clavicle possibly may cause life-threatening complications...
November 2017: Malaysian Orthopaedic Journal
https://www.readbyqxmd.com/read/29322889/outcomes-of-open-reduction-and-internal-fixation-in-displaced-intra-articular-scapular-fractures-a-case-series
#3
M Zahid, E H Rashid, H Inam, A J Zubairi, N Baloch, P M Hashmi
Scapular fractures are rare injuries and usually occur due to high energy trauma. Displaced Intra articular fractures usually require operative treatment and yields better outcomes as compared to conservative management. To assess the functional and radiological outcomes of displaced intra-articular scapular fractures managed with open reduction and internal fixation. 12 patients were retrospectively reviewed and included in the study. Post-operative functional outcomes were assessed using mean quick DASH (Disability of arm, hand and shoulder) score while radiological outcomes were analyzed as percentage of implant cut-through, mal-union, non-union or infection...
March 2017: Acta Orthopaedica Belgica
https://www.readbyqxmd.com/read/29310670/the-comparison-of-clinical-outcome-of-fresh-type-ii-odontoid-fracture-treatment-between-anterior-cannulated-screws-fixation-and-posterior-instrumentation-of-c1-2-without-fusion-a-retrospective-cohort-study
#4
Suomao Yuan, Bin Wei, Yonghao Tian, Jun Yan, Wanlong Xu, Lianlei Wang, Xinyu Liu
BACKGROUND: Recently, the excellent outcomes of temporary fixation of C1-2 without fusion in the treatment of odontoid fracture had been reported. It is still unclear if this technique could achieve the equivalent outcomes as the golden standard technique of anterior screw fixation. The objective of this study is to compare the clinical outcome of two treatments of fresh type II odontoid fracture: anterior cannulated screws fixation (ACSF) versus posterior instrumentation of C1-2 without fusion (PIWF)...
January 8, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29306499/an-alternative-treatment-for-osteoporotic-su-type-iii-periprosthetic-supracondylar-femur-fractures-double-locking-plate-fixation
#5
Hakan Çiçek, Ümit Tuhanioğlu, Hasan Ulaş Oğur, Fırat Seyfettinoğlu, Murat Bozkurt
INTRODUCTION: Patients with Su Type III fractures based on total knee arthroplasty (TKA) constitute a patient group with problematic treatment and management. Although it has difficulties, open reduction and internal fixation is one of the treatment options. METHOD: A retrospective evaluation was made of 22 patients surgically treated in our clinic with double locking, low contact titanium plate and screw for a Su Type III periprosthetic fracture based on TKA. The patients were evaluated with bone mineral densitometry, postoperative Knee Society Score (KSS), WOMAC and radiological evaluations...
January 3, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29301797/management-of-a-15-year-old-scaphoid-non-union
#6
Kai Yuen Wong, Olivia Sharp, Phillip Johnston
Scaphoid non-union affects wrist joint function and is often associated with a predictable pattern of degenerative change. A 30-year-old man presented with a symptomatic 15-year-old right scaphoid fracture with secondary scaphoid non-union advanced collapse of his right wrist. There was no evidence of avascular necrosis. The initial injury was from a fall onto his outstretched hand. We performed a right scaphoid open reduction, internal fixation and iliac crest bone graft. One year after the operation, the patient had good wrist function and grip strength...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29300693/antibodies-to-watch-in-2018
#7
Hélène Kaplon, Janice M Reichert
The pace of antibody therapeutics development accelerated in 2017, and this faster pace is projected to continue through 2018. Notably, the annual number of antibody therapeutics granted a first approval in either the European Union (EU) or United States (US) reached double-digits (total of 10) for the first time in 2017. The 10 antibodies granted approvals are: brodalumab, dupilumab, sarilumab, guselkumab, benralizumab, ocrelizumab, inotuzumab ozogamicin, avelumab, duvalumab, and emicizumab. Brodalumab, however, had already been approved in Japan in 2016...
January 4, 2018: MAbs
https://www.readbyqxmd.com/read/29300491/-clicking-gene-therapeutics-a-successful-union-of-chemistry-and-biomedicine-for-new-solutions
#8
Kira Astakova, Roslyn Ray, Maria Taskova, Jesper Uhd, Annika Carstens, Kevin Morris
The use of nucleic acid, DNA and RNA, based strategies to disrupt gene expression as a therapeutic is quickly emerging. Indeed, synthetic oligonucleotides represent a major component of emerging gene therapeutics. However, the efficiency and specificity of intracellular uptake for non-modified oligonucleotides is rather poor. Utilizing RNA based oligonucleotides as therapeutics is even more challenging to deliver, due to extremely fast enzymatic degradation of the RNAs. Similar to unmodified oligonucleotides, RNAs also get rapidly degraded in vivo and show large off-target binding even when they are able to reach and enter the desired target cells...
January 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29299654/comparative-study-of-open-and-arthroscopic-coracoid-transfer-for-shoulder-anterior-instability-latarjet-computed-tomography-evaluation-at-a-short-term-follow-up-part-ii
#9
Bartłomiej Kordasiewicz, Maciej Kicinski, Konrad Małachowski, Janusz Wieczorek, Sławomir Chaberek, Stanisław Pomianowski
PURPOSE AND HYPOTHESIS: The aim of this study was to evaluate and to compare the radiological parameters after arthroscopic and open Latarjet technique via evaluation of computed tomography (CT) scans. Our hypothesis was that the radiological results after arthroscopic stabilisation remained in the proximity of those results achieved after open stabilisation. MATERIAL AND METHODS: CT scan evaluation results of patients after primary Latarjet procedure were analysed...
January 4, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29299494/functional-results-of-unstable-type-2-distal-clavicle-fractures-treated-with-superior-anterior-locking-plate
#10
Rajesh Govindasamy, Saravanan Kasirajan, Tushar Doke
Background: The treatment of distal clavicle fracture is always a challenge, as it is mostly unstable and has higher rate of delayed union, malunion, non-union and associated acromioclavicular arthritis. So the management of these fractures remains controversial. The purpose of this study is to evaluate the functional results of Type 2 distal end clavicle fractures treated with superior anterior locking plate. Methods: From June 2011 to August 2015 a retrospective study of12 male patients (mean age of 41...
November 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29285371/en-bloc-resection-intraoperative-extracorporeal-irradiation-and-re-implantation-of-involved-bone-for-the-treatment-of-limb-malignancies
#11
Shuai Zhang, Xu-Quan Wang, Jia-Jia Wang, Mei-Tao Xu
Reconstruction of the defect following limb-sparing resection of malignant bone tumors is controversial and extremely challenging. Extracorporeal irradiation (ECI) and re-implantation have been used for limb salvage surgery for patients, with major advantages, including biological reconstruction, ready availability and preservation of bone stock, over replacement with a megaprosthesis. The purpose of the present study was to present our experience and details of all patients treated with this surgery. Between June 2005 and December 2014, we followed-up 23 patients with limb malignancies who were treated with en bloc excision followed by 50-Gy single dose ECI and re-implantation of involved bone segments...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29282524/perilunate-fracture-dislocations-clinical-and-radiological-results-of-21-cases
#12
Thomas Meszaros, Esther Vögelin, Lukas Mathys, Franck Marie Leclère
BACKGROUND: Perilunate dislocations and fracture-dislocations are a subcategory of the carpal instability complex. Herein, we report our university hospital experience with this complex injury. The goal of our study was to find predictive factors and quantify the development of arthritis and lunate necrosis. We tried to measure the impact of arthritis on hand function. METHODS: Between January 2000 and December 2014, 21 patients underwent surgery for perilunate dislocations and perilunate fracture-dislocations of the wrist in our tertiary university center...
December 27, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29280510/the-challenges-of-promoting-osteogenesis-in-segmental-bone-defects-and-osteoporosis
#13
REVIEW
Alyssa N Ball, Seth W Donahue, Samantha J Wojda, C Wayne McIlwraith, Christopher E Kawcak, Nicole Ehrhart, Laurie R Goodrich
Conventional clinical management of complex bone healing scenarios continues to result in 5-10% of fractures forming non-unions. Additionally, the aging population and prevalence of osteoporosis related fractures necessitate the further exploration of novel ways to augment osteogenesis in this special population. This review focuses on the current clinical modalities available, and the ongoing clinical and pre-clinical research to promote osteogenesis in segmental bone defects, delayed unions, and osteoporosis...
December 27, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29279812/first-metatarsophalangeal-joint-arthrodesis-in-hallux-valgus-versus-hallux-rigidus-using-cup-and-cone-preparation-compression-screw-and-dorsal-plate-fixation
#14
Calvin Chien, Terrence Alfred, Richard Freihaut, Sabrina Pit
Various techniques have been described for first metatarsophalangeal (MTP) joint arthrodesis. The purpose of this study was to determine if cup and cone preparation by a single surgeon with an interfragmentary screw and dorsal plate fixation provides a comparable union rate in hallux valgus versus hallux rigidus. Our study included all patients who underwent first MTP joint fusions using cup and cone preparation with an interfragmentary compression screw and dorsal plate fixation from 2010 to 2015. We compared union rates in 65 patients with hallux rigidus with 47 who had hallux valgus...
October 19, 2017: Curēus
https://www.readbyqxmd.com/read/29276535/influence-of-screw-type-and-length-on-fixation-of-anterior-glenoid-bone-grafts
#15
Laurent B Willemot, Ross Wodicka, Adrian Bosworth, Alessandro Castagna, Joseph Burns, Olivier Verborgt
Background: Bone-grafting procedures for recurrent shoulder instability produce low recurrence rates, although they are associated with complications such as graft non-union. Inadequate screw purchase is considered to play a causative role. However, excessive screw length can endanger neurovascular structures. The present study aimed to investigate how type and length of screws influences construct rigidity in a simplified glenoid model. Methods: Testing was performed on composite polyurethane foam models with material properties and abstract dimensions of a deficient glenoid and an bone graft...
January 2018: Shoulder & Elbow
https://www.readbyqxmd.com/read/29273576/opinion-redefining-the-role-of-the-physician-in-laboratory-medicine-in-the-context-of-emerging-technologies-personalised-medicine-and-patient-autonomy-4p-medicine
#16
REVIEW
Matthias Orth, Maria Averina, Stylianos Chatzipanagiotou, Gilbert Faure, Alexander Haushofer, Vesna Kusec, Augusto Machado, Siraj A Misbah, Wytze Oosterhuis, Kari Pulkki, Patrick J Twomey, Eberhard Wieland
The role of clinical pathologists or laboratory-based physicians is being challenged on several fronts-exponential advances in technology, increasing patient autonomy exercised in the right to directly request tests and the use of non-medical specialists as substitutes. In response, clinical pathologists have focused their energies on the pre-analytical and postanalytical phases of Laboratory Medicine thus emphasising their essential role in individualised medical interpretation of complex laboratory results...
December 22, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29259065/migration-pattern-and-mortality-of-ethnic-german-migrants-from-the-former-soviet-union-a-cohort-study-in-germany
#17
Simone Kaucher, Andreas Deckert, Heiko Becher, Volker Winkler
OBJECTIVE: We aimed to investigate all-cause and cause-specific mortality among ethnic German migrants from the former Soviet Union by different immigration periods to describe associations with migration pattern and mortality. DESIGN: We used pooled data from three retrospective cohort studies in Germany. PARTICIPANTS: Ethnic German migrants from the former Soviet Union (called resettlers), who immigrated to Germany since 1990 to the federal states North Rhine-Westphalia and Saarland and to the region of Augsburg (n=59 390)...
December 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/29250335/technical-particularities-of-joint-preserving-hip-surgery-in-osteopetrosis
#18
REVIEW
Reinhold Ganz, Guido Grappiolo, Jeffrey W Mast, Joel Matta, Luigino Turchetto
Proximal femoral fracture and coxarthrosis are the most common orthopaedic problems of osteopetrosis. Fracture fixation is difficult and one-third fail, with total hip replacement as the final solution. There is little reported experience about how to deal with this particular type of bone and what has been published to date is surprisingly non-specific. Corrective osteotomies are mainly undertaken in children for non-union of a fractured femoral neck and/or for coxa vara. However, any information about technical problems and solutions is scarce and barely instructive...
December 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/29248221/method-comparison-and-validation-of-a-prototype-device-for-measurement-of-ionized-calcium-concentrations-cow-side-against-a-point-of-care-instrument-and-a-benchtop-blood-gas-analyzer-reference-method
#19
R C Neves, T Stokol, K D Bach, J A A McArt
The objective of this study was to assess an optimized ion-selective electrode Ca-module prototype as a potential cow-side device for ionized Ca (iCa) measurements in bovine blood. A linearity experiment showed no deviation from linearity over a range of iCa concentrations compared with a commercial point-of-care (POC) device commonly used in the field (POCVS; VetScan i-STAT, Abaxis North America, Union City, CA) and a laboratory gold standard benchtop blood-gas analyzer [reference analyzer (RA); ABL-800 FLEX, Radiometer Medical, Copenhagen, Denmark]...
December 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29246480/treatment-of-infected-non-unions-of-the-femur-and-tibia-in-a-french-referral-center-for-complex-bone-and-joint-infections-outcomes-of-55-patients-after-2-to-11-years
#20
T Bauer, S Klouche, O Grimaud, A Lortat-Jacob, P Hardy
INTRODUCTION: An infected nonunion is a major complication following bone fracture. While bone union can be obtained in 70% to 100% of cases, treatment of osteomyelitis is less predictable, with reported healing rates ranging from 40% to 100%. The primary aim of this study was to assess the success rate of treating infected non-unions of the tibia and femur by a team specializing in complex bone and joint infections. MATERIAL AND METHODS: This single-center retrospective study included all patients operated between 2002 and 2012 due to an infected nonunion of the femur or tibia using standardized surgical methods...
December 12, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
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