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https://www.readbyqxmd.com/read/28350850/defective-bone-repair-in-mast-cell-deficient-cpa3cre-mice
#1
Jose Luis Ramirez-GarciaLuna, Daniel Chan, Robert Samberg, Mira Abou-Rjeili, Timothy H Wong, Ailian Li, Thorsten B Feyerabend, Hans-Reimer Rodewald, Janet E Henderson, Paul A Martineau
In the adult skeleton, cells of the immune system interact with those of the skeleton during all phases of bone repair to influence the outcome. Mast cells are immune cells best known for their pathologic role in allergy, and may be involved in chronic inflammatory and fibrotic disorders. Potential roles for mast cells in tissue homeostasis, vascularization and repair remain enigmatic. Previous studies in combined mast cell- and Kit-deficient KitW-sh/W-sh mice (KitW-sh) implicated mast cells in bone repair but KitW-sh mice suffer from additional Kit-dependent hematopoietic and non- hematopoietic deficiencies that could have confounded the outcome...
2017: PloS One
https://www.readbyqxmd.com/read/28344544/the-association-between-occupational-secondhand-smoke-exposure-and-life-satisfaction-among-adults-in-the-european-union
#2
Nikita B Rajani, Iris T Vlachantoni, Constantine I Vardavas, Filippos T Filippidis
BACKGROUND: Despite existing legislation, a large proportion of the European Union (EU) population is exposed to occupational secondhand smoke (SHS). The aim of this study was to explore associations between occupational exposure to SHS and self-reported life satisfaction. METHODS: We analysed data collected through the Eurobarometer survey (wave 82.4) from n = 11,788 individuals working in indoor spaces. The sample was representative of the population of the 28 EU member states...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/28339776/effect-of-acute-millimeter-wave-exposure-on-dopamine-metabolism-of-ngf-treated-pc12-cells
#3
Alexis J Haas, Yann Le Page, Maxim Zhadobov, Ronan Sauleau, Yves Le Dréan, Christian Saligaut
Several forthcoming wireless telecommunication systems will use electromagnetic frequencies at millimeter waves (MMWs), and technologies developed around the 60-GHz band will soon know a widespread distribution. Free nerve endings within the skin have been suggested to be the targets of MMW therapy which has been used in the former Soviet Union. So far, no studies have assessed the impact of MMW exposure on neuronal metabolism. Here, we investigated the effects of a 24-h MMW exposure at 60.4 GHz, with an incident power density (IPD) of 5 mW/cm², on the dopaminergic turnover of NGF-treated PC12 cells...
February 24, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28337895/use-of-supercharged-cover-screw-as-static-magnetic-field-generator-for-bone-healing-1st-part-in-vitro-enhancement-of-osteoblast-like-cell-differentiation
#4
F Bambini, A Santarelli, A Putignano, M Procaccini, G Orsini, L Memè, D Sartini, M Emanuelli, L Lo Muzio
Since 1979, Pulsed electromagnetic fields (PEMFs) have been approved by the Food and Drug Administration as an effective method in the treatment of non-unions. As well as PEMFs, also static magnetic fields (SMFs) have been widely investigated in orthopaedic studies. Even if the exact mechanism of action is not well understood, a large number of studies showed specific effects both at cellular and tissue levels. As bone fracture healing and osseointegration share the same biological events, the application of magnetic field stimulation in order to facilitate the osseointegration process has been suggested...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28335036/validated-method-for-the-screening-and-quantification-of-baclofen-gabapentin-and-pregabalin-in-human-post-mortem-whole-blood-using-protein-precipitation-and-liquid-chromatography-tandem-mass-spectrometry
#5
Limon Nahar, Amy Smith, Rajan Patel, Rebecca Andrews, Sue Paterson
There has been a rapid increase in the number of prescriptions for baclofen (BLF), gabapentin (GBP) and pregabalin (PGL) in the UK since their introduction to therapy. Recent studies across the European Union and USA have shown the illicit abuse potential of these drugs and deaths have been observed. A simple, reliable and fully validated method was developed for the screening and quantification of BLF, GBP and PGL in human post-mortem (PM) blood. The analytes and their deuterated analogs as internal standard were extracted from blood using a single addition acetonitrile protein precipitation reaction followed by analysis using liquid chromatography-tandem mass spectrometry (LC-MS-MS) with triggered dynamic multiple reaction monitoring mode for simultaneous confirmation and quantification...
March 10, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334772/transparency-policies-of-the-european-medicines-agency-has-the-paradigm-shifted
#6
Daria Kim
This article reflects on the state of play as regards access to non-summary clinical trial data in the European Union (EU). In particular, it examines the scope of access under the recent transparency policies of the European Medicines Agency (EMA) that attempt to break away from the presumptively confidential treatment of clinical trial data. In light of the emerging case law of the Court of Justice of the European Union on clinical trial data disclosure, it remains highly uncertain what data, and under what conditions, can be lawfully released by the EMA...
February 23, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28324799/modified-masquelet-technique-using-allogeneic-umbilical-cord-derived-mesenchymal-stem-cells-for-infected-non-union-femoral-shaft-fracture-with-a-12-cm-bone-defect-a-case-report
#7
Ismail Hadisoebroto Dilogo, Muhammad Rizqi Adhi Primaputra, Jeanne Adiwinata Pawitan, Isabella Kurnia Liem
INTRODUCTION: Non-union due to large bone loss often causes significant long-term morbidity. We incorporate the use of allogeneic umbilical cord-derived mesenchymal stem cells (UC-MSCs) as part of the diamond concept of regenerative medicine in a case of infected non-union fracture. PRESENTATION OF CASE: We reported a 54-year-old female patient presenting with pain on the right thigh. She was previously diagnosed with a closed fracture of the right femoral shaft and underwent four surgeries before finally being referred to Dr...
March 6, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28300706/tapered-stems-one-third-proximally-coated-have-higher-complication-rates-than-cylindrical-two-third-coated-stems-in-patients-with-high-hip-dislocation-undergoing-total-hip-arthroplasty-with-step-cut-shortening-osteotomy
#8
Vahit Emre Ozden, Goksel Dikmen, Burak Beksac, Ismail Remzi Tozun
BACKGROUND: The results of cementless stems in total hip arthroplasty (THA) done because of congenital dislocation with step-cut osteotomy is not well known, particularly the influence of the design and the role of extent of porous coating. Therefore we performed a retrospective study to evaluate the mid to long-term results THA performed with a single type acetabular component and different geometry and fixation type stems with ceramic bearings in the setting of step-cut subtrochanteric osteotomy in high hip dislocated (HHD) patients...
March 11, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28288688/postoperative-brachial-artery-entrapment-associated-with-pediatric-supracondylar-fracture-of-the-humerus-a-case-report
#9
David Latz, Jan Grassmann, Erik Schiffner, Sebastian Gehrmann, Mansur Duran, Joachim Windolf, Pascal Jungbluth
BACKGROUND: Severely displaced supracondylar fractures of the humerus in children are frequently associated with complications including neurovascular injuries, non-union, or compartment syndrome. In the current literature, no report exists about postoperative brachial artery entrapment in combination with an inconspicuous preoperative neurovascular examination. CASE PRESENTATION: We present a case of a 6-year-old white boy with a pulseless radial and ulnar artery after open reduction and internal fixation of a severely displaced supracondylar fracture of his right humerus (Gartland type III) using four K-wires...
March 14, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28284470/virtual-fracture-clinic-management-of-fifth-metatarsal-including-jones-fractures-is-safe-and-cost-effective
#10
Kit Brogan, Simon Bellringer, Harold Akehurst, Christopher Gee, Nada Ibrahim, Lucy Cassidy, Ben Rogers, James Gibbs
Virtual clinics have been shown to be safe and cost-effective in many specialties, yet barriers exist to their implementation in orthopaedics. The aims of this study were to look at whether the management of 5th metatarsal fractures using a virtual fracture clinic model is safe, cost effective and avoids adverse outcomes whilst being acceptable to patients using the service. All patients with a fifth metatarsal fracture between September 2013 and September 2015 had a standardised management plan initiated (blackboot, full weightbearing) in the emergency department (ED)...
February 12, 2017: Injury
https://www.readbyqxmd.com/read/28283838/the-effect-of-nsaids-on-spinal-fusion-a-cross-disciplinary-review-of-biochemical-animal-and-human-studies
#11
REVIEW
Ahilan Sivaganesan, Silky Chotai, Gabrielle White-Dzuro, Matthew J McGirt, Clinton J Devin
PURPOSE: Non-steroidal anti-inflammatory drugs (NSAIDs) play an important role in postoperative pain management. However, their use in the setting of spine fusion surgery setting has long been a topic of controversy. In this review we examined relevant research, including in vivo, animal, and clinical human studies, with the aim of understanding the effect of NSAIDs on spinal fusion. STUDY DESIGN/SETTING: Systematic review of study designs of all types from randomized controlled trials and meta-analyses to single-institution retrospective reviews...
March 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28280994/detection-of-myd88-l265p-and-whim-like-cxcr4-mutation-in-patients-with-igm-monoclonal-gammopathy-related-disease
#12
Xin-Xin Cao, Qi Meng, Hao Cai, Tian-Hua He, Cong-Li Zhang, Wei Su, Jian Sun, Yue Li, Wei Xu, Dao-Bin Zhou, Jian Li
A broad spectrum of diseases are associated with IgM monoclonal gammopathy, including Waldenstrom macroglobulinemia (WM), various types of B cell non-Hodgkin's lymphoma (NHL), multiple myeloma (MM), primary amyloidosis (AL), and monoclonal gammopathy of undetermined significance (MGUS); these are called IgM monoclonal gammopathy related diseases (IgM-RD). We investigated MYD88 L265P and WHIM-like CXCR4 mutations in various IgM-RD. Patients with serum immunofixation electrophoresis confirmed IgM monoclonal gammopathy who had enough material for DNA extraction and presented between January 2008 and October 2016 at Peking Union Medical College Hospital were enrolled in this cohort...
March 9, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28280708/evaluation-of-postoperative-complications-according-to-treatment-of-third-molars-in-mandibular-angle-fracture
#13
Hye-Youn Lim, Tae-Young Jung, Sang-Jun Park
OBJECTIVES: The aim of this study was to evaluate the implication of third molars in postoperative complications of mandibular angle fracture with open reduction and internal fixation (ORIF). MATERIALS AND METHODS: Data were collected on patients who presented with mandibular angle fracture at our Department of Oral and Maxillofacial Surgery between January 2011 and December 2015. Of the 63 total patients who underwent ORIF and perioperative intermaxillary fixation (IMF) with an arch bar, 49 patients were identified as having third molars in the fracture line and were followed up with until plate removal...
February 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/28279204/a-study-to-compare-the-efficacy-of-polyether-ether-ketone-rod-device-with-titanium-devices-in-posterior-spinal-fusion-in-a-canine-model
#14
Nanxiang Wang, Huanxin Xie, Chunyang Xi, Han Zhang, Jinglong Yan
BACKGROUND: The benefits of posterior lumbar fusion surgery with orthotopic paraspinal muscle-pediculated bone flaps are well established. However, the problem of non-union due to mechanical support is not completely resolved. The aim of the study was to compare the efficacy of polyether ether ketone (PEEK) rod device with conventional titanium devices in the posterior lumbar fusion surgery with orthotopic paraspinal muscle-pediculated bone flaps. METHODS: This was a randomized controlled study with an experimental animal model...
March 9, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28278149/-socioeconomic-costs-of-asthma-in-the-european-union-united-states-and-canada-a-systematic-review
#15
REVIEW
Jaume Puig-Junoy, Natàlia Pascual-Argenté
BACKGROUND: Asthma is responsible for a large number of doctor and emergency visits due to exacerbations and inadequate control of the disease, which give rise to very high associated economic costs. The social cost of asthma comprises both the healthcare and non-healthcare costs. The purpose of this study was to analyse up-to-date estimates of the social cost of asthma, with special reference to the influence of level of severity and degree of control. METHODS: A systematic review of original cost-of-illness studies of asthma published in English or Spanish between January 2004 and December 2014 and indexed in PubMed, IBECS or IME was conducted...
March 9, 2017: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/28276911/the-effect-of-physical-contact-on-changes-in-fatigue-markers-following-rugby-union-field-based-training
#16
Gregory Roe, Joshua Darrall-Jones, Kevin Till, Padraic Phibbs, Dale Read, Jonathon Weakley, Andrew Rock, Ben Jones
Repeated physical contact in rugby union is thought to contribute to post-match fatigue; however, no evidence exists on the effect of contact activity during field-based training on fatigue responses. Therefore, the purpose of this study was to examine the effect of contact during training on fatigue markers in rugby union players. Twenty academy rugby union players participated in the cross-over study. The magnitude of change in upper- and lower-body neuromuscular function (NMF), whole blood creatine kinase concentration [CK] and perception of well-being was assessed pre-training (baseline), immediately and 24 h post-training following contact and non-contact, field-based training...
February 26, 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28274470/surgical-outcome-of-intramedullary-nailing-in-patients-with-complete-atypical-femoral-fracture-a-multicenter-retrospective-study
#17
Kyung-Jae Lee, Jeong Joon Yoo, Kwang-Jun Oh, Je-Hyun Yoo, Kee Hyung Rhyu, Kwang Woo Nam, Dong-Hoon Suh
BACKGROUND: Management of atypical femoral fracture on bisphosphonate therapy still remains controversy and is reported high rate of complications. The aim of this study was to evaluate the outcome of intramedullary nailing in patients with atypical femoral fracture who took bisphosphonate more than one year through the multicenter retrospective study. METHODS: We gathered 75 atypical femoral fractures from seven institutions between 2009 and 2014. Among them 46 atypical femoral fractures which met the inclusion criteria was evaluated in this study...
March 1, 2017: Injury
https://www.readbyqxmd.com/read/28274008/to-operate-or-not-to-operate-the-mid-shaft-fractures-of-the-clavicle-a-comparative-study-of-functional-outcomes-of-the-two-methods-of-management
#18
Sanath Kumar Shetty, Ragesh Chandran, Arjun Ballal, Lawrence John Mathias, Anoop Hegde, Ashwin Shetty
INTRODUCTION: Fractures of the clavicle are some of the most common fractures which are seen in the adult population. Mid-shaft fractures of the clavicle are considered the most common form of clavicle fractures and about half of them are displaced fractures. They have been managed non-operatively over the years. However, severe displacement and comminution of these fractures have warranted the requirement of operative intervention, due to increased incidence of mal-union, worsening of shoulder functions etc...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273496/ertl-and-non-ertl-amputees-exhibit-functional-biomechanical-differences-during-the-sit-to-stand-task
#19
Abbie E Ferris, Cory L Christiansen, Gary D Heise, David Hahn, Jeremy D Smith
BACKGROUND: People with transtibial amputation stand ~50times/day. There are two general approaches to transtibial amputation: 1) distal tibia and fibula union using a "bone-bridge" (Ertl), 2) non-union of the tibia and fibula (Non-Ertl). The Ertl technique may improve functional outcomes by increasing the end-bearing ability of the residual limb. We hypothesized individuals with an Ertl would perform a five-time sit-to-stand task faster through greater involvement/end-bearing of the affected limb...
February 22, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28272352/trauma-and-stem-cells-biology-and-potential-therapeutic-implications
#20
REVIEW
Kabilan Thurairajah, Matthew L Broadhead, Zsolt J Balogh
Trauma may cause irreversible tissue damage and loss of function despite current best practice. Healing is dependent both on the nature of the injury and the intrinsic biological capacity of those tissues for healing. Preclinical research has highlighted stem cell therapy as a potential avenue for improving outcomes for injuries with poor healing capacity. Additionally, trauma activates the immune system and alters stem cell behaviour. This paper reviews the current literature on stem cells and its relevance to trauma care...
March 7, 2017: International Journal of Molecular Sciences
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