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https://www.readbyqxmd.com/read/27913025/mapping-monthly-rainfall-erosivity-in-europe
#1
Cristiano Ballabio, Pasquale Borrelli, Jonathan Spinoni, Katrin Meusburger, Silas Michaelides, Santiago Beguería, Andreas Klik, Sašo Petan, Miloslav Janeček, Preben Olsen, Juha Aalto, Mónika Lakatos, Anna Rymszewicz, Alexandru Dumitrescu, Melita Perčec Tadić, Nazzareno Diodato, Julia Kostalova, Svetla Rousseva, Kazimierz Banasik, Christine Alewell, Panos Panagos
Rainfall erosivity as a dynamic factor of soil loss by water erosion is modelled intra-annually for the first time at European scale. The development of Rainfall Erosivity Database at European Scale (REDES) and its 2015 update with the extension to monthly component allowed to develop monthly and seasonal R-factor maps and assess rainfall erosivity both spatially and temporally. During winter months, significant rainfall erosivity is present only in part of the Mediterranean countries. A sudden increase of erosivity occurs in major part of European Union (except Mediterranean basin, western part of Britain and Ireland) in May and the highest values are registered during summer months...
November 29, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27911364/an-intramedullary-locking-nail-for-standardized-fixation-of-femur-osteotomies-to-analyze-normal-and-defective-bone-healing-in-mice
#2
Tina Histing, Michael D Menger, Tim Pohlemann, Romano Matthys, Tobias Fritz, Patric Garcia, Moritz Klein
Bone healing models are essential to the development of new therapeutic strategies for clinical fracture treatment. Furthermore, mouse models are becoming more commonly used in trauma research. They offer a large number of mutant strains and antibodies for the analysis of the molecular mechanisms behind the highly differentiated process of bone healing. To control the biomechanical environment, standardized and well-characterized osteosynthesis techniques are mandatory in mice. Here, we report on the design and use of an intramedullary nail to stabilize open femur osteotomies in mice...
November 13, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27909656/outcomes-of-demineralized-bone-matrix-enriched-with-concentrated-bone-marrow-aspirate-in-lumbar-fusion
#3
Remi M Ajiboye, Mark A Eckardt, Jason T Hamamoto, Benjamin Plotkin, Michael D Daubs, Jeffrey C Wang
BACKGROUND: Multiple studies have demonstrated that a significant amount of variability exists in various demineralized bone matrix (DBM) formulations, which casts doubts on its reliability in consistently promoting fusion. Bone marrow aspirate (BMA) is a cellular based graft that contains mesenchymal stem cells (MSCs) and growth factors can confer osteogenic and osteoinductive potential to DBM. The goal of this study was to describe the outcome of DBM enriched with concentrated BMA in patients undergoing combined lumbar interbody and posterolateral fusion...
2016: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/27907138/barriers-to-modern-contraceptive-use-in-kinshasa-drc
#4
Mbadu Muanda, Parfait Gahungu Ndongo, Leah D Taub, Jane T Bertrand
Recent research from Kinshasa, DRC, has shown that only one in five married women uses modern contraception; over one quarter have an unmet need for family planning; and almost 400 health facilities across Kinshasa report that they provide modern contraception. This study addresses the question: with reasonable physical access and relatively high unmet need, why is modern contraceptive prevalence so low? To this end, the research team conducted 6 focus groups of women (non-users of any method, users of traditional methods, and users of modern methods) and 4 of husbands (of users of traditional methods and in non-user unions) in health zones with relatively strong physical access to FP services...
2016: PloS One
https://www.readbyqxmd.com/read/27904818/the-government-s-role-in-regulating-coordinating-and-standardizing-the-response-to-alzheimer-s-disease-anticipated-international-cooperation-in-the-area-of-intractable-and-rare-diseases
#5
REVIEW
Qi Tang, Peipei Song, Lingzhong Xu
The World Health Organization (WHO) has emphasized that aging of the population is inextricably linked to many other global public health issues, such as universal health coverage, non-communicable diseases, and disability. However, Alzheimer's Disease International (ADI) estimates that 46.8 million elderly people worldwide were living with dementia in 2015. Alzheimer's disease (AD), the most common form of dementia, is one of the most common neurodegenerative diseases and is the main cause of cognitive impairment...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27901409/a-non-invasive-in-vitro-monitoring-system-reporting-skeletal-muscle-differentiation
#6
Deniz Öztürk-Kaloglu, David Hercher, Philipp Heher, Katja Posa-Markaryan, Simon Sperger, Alice Zimmermann, Susanne Wolbank, Heinz Redl, Ara Hacobian
Monitoring of cell differentiation is a crucial aspect of cell-based therapeutic strategies depending on tissue maturation. In this study we have developed a non-invasive reporter system to trace murine skeletal muscle differentiation. Either a secreted bioluminescent reporter (Metridia luciferase) or a fluorescent reporter (GFP) was placed under the control of the truncated muscle creatine kinase (MCK) basal promoter enhanced by variable numbers of upstream MCK E-boxes. The engineered pE3MCK vector, coding a triple tandem of E-Boxes and the truncated MCK promoter, showed 20-fold higher levels of luciferase activation compared to a CMV promoter...
November 30, 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/27900307/arthroscopic-fixation-of-coronoid-process-fractures-through-coronoid-tunnelling-and-capsular-plication
#7
Paolo Arrigoni, Riccardo D'Ambrosi, Davide Cucchi, Simone Nicoletti, Enrico Guerra
PURPOSE: the purpose of this study is to describe a new arthroscopic technique for reduction and fixation of coronoid process fractures (CPFs) and report clinical and functional results in 4 patients after a 24-month follow-up. METHODS: four patients underwent arthroscopic reduction and fixation of isolated CPFs (acute or non-unions, type I or type II according to the Regan-Morrey classification) performed using a new technique based on coronoid tunnelling and capsular plication...
July 2016: Joints
https://www.readbyqxmd.com/read/27900192/vertical-stiffness-is-not-related-to-anterior-cruciate-ligament-elongation-in-professional-rugby-union-players
#8
Benjamin G Serpell, Jennie M Scarvell, Mark R Pickering, Nick B Ball, Diana Perriman, John Warmenhoven, Paul N Smith
BACKGROUND: Novel research surrounding anterior cruciate ligament (ACL) injury is necessary because ACL injury rates have remained unchanged for several decades. An area of ACL risk mitigation which has not been well researched relates to vertical stiffness. The relationship between increased vertical stiffness and increased ground reaction force suggests that vertical stiffness may be related to ACL injury risk. However, given that increased dynamic knee joint stability has been shown to be associated with vertical stiffness, it is possible that modification of vertical stiffness could help to protect against injury...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27900149/video-analysis-of-concussion-injury-mechanism-in-under-18-rugby
#9
Sharief Hendricks, Sam O'Connor, Michael Lambert, James C Brown, Nicholas Burger, Sarah Mc Fie, Clint Readhead, Wayne Viljoen
BACKGROUND: Understanding the mechanism of injury is necessary for the development of effective injury prevention strategies. Video analysis of injuries provides valuable information on the playing situation and athlete-movement patterns, which can be used to formulate these strategies. Therefore, we conducted a video analysis of the mechanism of concussion injury in junior-level rugby union and compared it with a representative and matched non-injury sample. METHODS: Injury reports for 18 concussion events were collected from the 2011 to 2013 under-18 Craven Week tournaments...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899272/risk-factors-for-intervertebral-instability-assessed-by-temporal-evaluation-of-the-radiographs-and-reconstructed-computed-tomography-images-after-l5-s1-single-level-transforaminal-interbody-fusion-a-retrospective-study
#10
Yoshiomi Kobayashi, Yoshio Shinozaki, Yohei Takahashi, Hironari Takaishi, Jun Ogawa
Intervertebral instability risks following L5-S1 transforaminal lumbar interbody fusion (TLIF) and causes of bony bridge formation on computed tomography (CT) remain largely unknown. We evaluated the temporal changes on plain radiographs and reconstructed CT images from 178 patients who had undergone single-level L5-S1 TLIF between February 2011 and February 2015. We statistically analyzed temporal changes the L5-S1 angle on radiographs and intervertebral stability (IVS) at the last observation. Bony bridge formation between the L5-S1 vertebral bodies and the titanium cage subsidence were analyzed by using reconstructed CT...
October 28, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27896458/prognostic-factors-in-the-treatment-of-carpal-scaphoid-non-unions
#11
F Schuind, F Moungondo, W El Kazzi
In this literature review, the authors analyse the prognostic factors in the curative treatment of scaphoid non-unions. The main negative prognostic factors are smoking, the time elapsed since the fracture, and avascular necrosis of the proximal fragment. If the latter is present, the revascularization by a pedicle or microsurgical bone autograft is probably the treatment of choice. In non-unions without evidence of osteonecrosis, vascularized bone grafts are probably not superior to conventional bone grafts, which can presently be performed under arthroscopic control, with minimal morbidity...
November 28, 2016: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/27895471/adherence-satisfaction-and-preferences-for-treatment-in-patients-with-psoriasis-in-the-european-union-a-systematic-review-of-the-literature
#12
I Belinchón, R Rivera, C Blanch, M Comellas, L Lizán
BACKGROUND AND OBJECTIVE: Adherence to treatment in patients with psoriasis is often poor. An investigation of patient preferences and satisfaction with treatment may be important, based on the expected correlation with therapy compliance. This paper aims to examine and describe the current literature on patient preferences, satisfaction and adherence to treatment for psoriasis in the European Union (EU). METHODS: Electronic searches were conducted using PubMed, ISI Web of Knowledge, Scopus, Spanish databases and Google Scholar...
2016: Patient Preference and Adherence
https://www.readbyqxmd.com/read/27894835/reducing-resource-utilization-during-non-operative-treatment-of-pediatric-proximal-humerus-fractures
#13
A Z Gladstein, A T Schade, A W Howard, M W Camp
INTRODUCTION: The majority of proximal humeral fractures in the skeletally immature are treated non-operatively. Operative indications vary but are largely based on degree of displacement. Non-union is rare. Non-operatively treated fractures are typically monitored radiographically to assess healing. HYPOTHESIS: We hypothesize that the decision to treat fractures operatively is made at the time of first imaging and that follow-up X-rays do not lead to a change in management...
November 25, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27894695/the-performance-of-atmospheric-pressure-gas-chromatography-tandem-mass-spectrometry-compared-to-gas-chromatography-high-resolution-mass-spectrometry-for-the-analysis-of-polychlorinated-dioxins-and-pcbs-in-food-and-feed-samples
#14
Guillaume Ten Dam, Igor Cabreira Pussente, Georges Scholl, Gauthier Eppe, Alexander Schaechtele, Stefan van Leeuwen
Recently, gas chromatography tandem mass spectrometry (GC-MS/MS) has been added in European Union (EU) legislation as an alternative to magnetic sector high resolution mass spectrometry (HRMS) for the analysis of dioxins and dioxin like polychlorinated biphenyls (dl-PCB) in food and feed. In this study the performance of APGC-MS/MS compared to GC-HRMS is investigated and compared with EU legislation. The study includes the legislative parameters, relative intermediate precision standard deviation (SRw,rel), trueness, sensitivity, linear range and ion ratio tolerance...
November 22, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27890247/reproducibility-of-x-rays-and-ct-arthrography-in-slac-snac-scac-wrists
#15
R Belhaouane, N Lebeau, C Maes-Clavier, C Hustin, E Krief, B Bonnaire, M Warin, V Rotari, E David
The purpose of this study was to assess the inter-observer and intra-observer reproducibility of the interpretation of CT arthrography and plain X-rays for scapholunate advanced collapse (SLAC), scaphoid non-union advanced collapse (SNAC) and scaphoid chondrocalcinosis advanced collapse (SCAC) wrist conditions, as well as the clinical relevance of these imaging modalities. The CT and X-rays images were reviewed twice in a blinded and randomized manner by two experienced orthopedic surgeons specialized in hand surgery, two orthopedic surgery residents and two experienced radiologists specialized in bone and joint imaging...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27889111/minimally-invasive-fixation-in-tibial-plateau-fractures-using-an-pre-operative-and-intra-operative-real-size-3d-printing
#16
Silvio Giannetti, Nicola Bizzotto, Andrea Stancati, Attilio Santucci
The purpose of our study was to compare the outcome after minimally invasive reconstruction and internal fixation with and without the use of pre- and intra-operative real size 3D printing for patients with displaced tibial plateau fractures (TPFs). We prospectively followed up 40 consecutive adult patients with closed TPF who underwent surgical treatment of reconstruction of the tibial plateau with the use of minimally invasive fixation. Sixteen patients (group 1) were operated using a pre-operative and intra-operative real size 3D-model, while 24 patients (group 2) were operated without 3D-model printing, but using only pre-operative and intra-operative 3D Tc-scan images...
November 18, 2016: Injury
https://www.readbyqxmd.com/read/27888295/platelet-rich-plasma-for-the-treatment-of-bone-defects-from-pre-clinical-rational-to-evidence-in-the-clinical-practice-a-systematic-review
#17
REVIEW
Alice Roffi, Berardo Di Matteo, Gopal Shankar Krishnakumar, Elizaveta Kon, Giuseppe Filardo
PURPOSE: The treatment of large bone defects represents a significant challenge for orthopaedic surgeons. In recent years, biologic agents have also been used to further improve bone healing. Among these, platelet-rich plasma (PRP) is the most exploited strategy. The aim of the present study was to systematically review the available literature to identify: 1) preclinical in-vivo results supporting the rational of PRP use for bone healing; 2) evidence from the clinical practice on the actual clinical benefit of PRP for the treatment of fractures and complications such as delayed unions and non-unions...
November 26, 2016: International Orthopaedics
https://www.readbyqxmd.com/read/27885844/guidance-to-manage-inappropriate-polypharmacy-in-older-people-systematic-review-and-future-developments
#18
Derek Stewart, Alpana Mair, Martin Wilson, Przemyslaw Kardas, Pawel Lewek, Albert Alonso, Jennifer McIntosh, Katie MacLure
Single disease state led evidence-based guidelines do not provide sufficient coverage of issues of multimorbidities, with the cumulative impact of recommendations often resulting in overwhelming medicines burden. Inappropriate polypharmacy increases the likelihood of adverse drug events, drug interactions and non-adherence. Areas covered: A detailed description of a pan-European initiative, 'Stimulating Innovation Management of Polypharmacy and Adherence in the Elderly, SIMPATHY', which is a project funded by the European Commission to support innovation across the European Union...
November 25, 2016: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/27879570/bone-turnover-markers-as-a-new-predicting-factor-for-non-union-after-spinal-fusion-surgery
#19
Hiroyuki Inose, Tsuyoshi Yamada, Mieradili Mulati, Takashi Hirai, Shuta Ushio, Toshitaka Yoshii, Tsuyoshi Kato, Shigenori Kawabata, Atsushi Okawa
STUDY DESIGN: Retrospective observational study. OBJECTIVE: We investigated whether bone turnover markers could be a useful indicator for prediction of nonunion. SUMMARY OF BACKGROUND DATA: Nonunion is a major complication of lumbar spinal fusion surgery. However, the involvement of bone turnover in the process of bony union in spinal fusion surgery is poorly understood. METHODS: Of the 74 patients analyzed, 13 were diagnosed with nonunion...
November 22, 2016: Spine
https://www.readbyqxmd.com/read/27876583/treatment-ofpediatric-forearm-midshaft-fractures-is-there-a-difference-between-types-of-orthopedic-surgeon
#20
Di Lu, Zhou Lin, Jing-Dong Zhang, Hua Chen, Liao-Jun Sun
PURPOSE OF THE STUDY: The objective of this study was tocompare the clinical and radiological outcomes of pediatric forearmmidshaft fractures treated operatively with titanium elastic nails (TENs) bypediatric orthopedists and non-pediatric orthopedists. MATERIAL AND METHODS: We conducted a prospective cohort study of 88 childrenofforearmmidshaft fractures, who were randomized to operative stabilization eitherby pediatric orthopedists (Group A, 44 cases) or by non-pediatric orthopedists (Group B, 44 cases) from April 2013 to February 2014...
November 19, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
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