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https://www.readbyqxmd.com/read/28645888/hiv-strategic-information-in-non-european-union-countries-in-the-world-health-organization-european-region-capacity-development-needs
#1
Ivana Bozicevic, Senad Handanagic, Jurja Ivana Cakalo, Annemarie Rinder Stengaard, George Rutherford
BACKGROUND: Capacity building of the national HIV strategic information system is a core component of the response to the HIV epidemic as it enables understanding of the evolving nature of the epidemic, which is critical for program planning and identification of the gaps and deficiencies in HIV programs. OBJECTIVE: The study aims to describe the results of the assessment of the needs for further development of capacities in HIV strategic information systems in the non-European Union (EU) countries in the World Health Organization European Region (EUR)...
June 23, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28645497/an-association-between-polymorphisms-within-the-apoe-gene-and-concussion-aetiology-in-rugby-union-players
#2
Shameemah Abrahams, Sarah Mc Fie, Jon Patricios, Jason Suter, Michael Posthumus, Alison V September
OBJECTIVES: Concussion refers to changes in neurological function due to biomechanical forces transmitted to the head. The APOE ε4 allele is associated with brain injury severity. The objective was to determine if APOE gene variants are associated with concussion history and severity in rugby players. DESIGN: In total, 128 non-concussed controls and 160 previously concussed participants (all cases N=160; diagnosed N=139) were recruited from high school (junior, N=121), club (N=116) and professional rugby teams (N=51)...
June 8, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28645423/a-technique-for-extraction-of-the-distal-segment-of-a-broken-femoral-nail-using-a-flexible-reamer
#3
C Zhao, G J R Slater
INTRODUCTION: Extraction of broken femoral nails in peri-implant fractures is becoming an increasingly common problem faced by orthopaedic surgeons. Different closed and open techniques for removal of broken nails have been previously described but due to variations in equipment and fracture configurations these methods are not always easily reproducible. We describe an open surgical technique using simple equipment that can be utilised when other methods of extraction have failed. CASE PRESENTATION AND SURGICAL TECHNIQUE: We present a case of a peri-implant fracture secondary to non-union involving a short cephalomedullary nail where the broken distal segment of nail was significantly more distal to the femoral fracture site...
June 16, 2017: Injury
https://www.readbyqxmd.com/read/28643535/efficacy-of-platelets-in-bone-healing-a-systematic-review-on-animal-studies
#4
Sabrina Marcazzan, Roberto Lodovico Weinstein, Massimo Del Fabbro
In presence of large bone defects, delayed bone union, non-union, fractures, and implant surgery, bone reconstruction may be necessary. Different strategies have been employed to enhance bone healing among which the use of autologous platelet concentrates. Due to the high content of platelets and platelet-derived bioactive molecules (e.g., growth factors, antimicrobial peptides), they are promising candidates to increase bone healing. However, a high heterogeneity of both preclinical and clinical studies resulted in contrasting results...
June 23, 2017: Platelets
https://www.readbyqxmd.com/read/28643310/-establishment-of-a-prognostic-nomogram-to-predict-long-term-survival-in-non-metastatic-colorectal-cancer-patients
#5
Xiaojie Wang, Pan Chi, Huiming Lin, Xingrong Lu, Ying Huang, Zongbin Xu, Shenghui Huang, Yanwu Sun, Daoxiong Ye
OBJECTIVE: To establish a nomogram to predict long-term survival in non-metastatic colorectal cancer patients. METHODS: A retrospective analysis was conducted in patients with non-metastatic colorectal cancer who underwent radical surgery in the Department of Colorectal Surgery of Affiliated Union Hospital of Fujian Medical University between January 2000 and December 2014. Univariate and multivariate analyses on disease-free survival (DFS) were performed using the Cox proportional regression model...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28643278/health-risks-of-environmental-exposure-to-metals-and-herbicides-in-the-pardo-river-brazil
#6
Carolina S Machado, Brisa M Fregonesi, Renato I S Alves, Karina A A Tonani, Jordi Sierra, Bruno S Martinis, Beatriz S Celere, Montse Mari, Marta Schuhmacher, Martí Nadal, Jose L Domingo, Susana Segura-Muñoz
Mixture of metals and herbicides in rivers may pose relevant risks for the health of surrounding communities. Humans may be exposed to river pollution through intake of contaminated water and fish, as well as irrigated agricultural products. The aim of this study was to assess the human health risks of environmental exposure to metals and herbicides through water and fish intake in the Pardo River. Metals (Al, As, Be, Cd, Cr, Cu, Pb, Mn, Hg, Ni, Tl, Sn, V, and Zn) were analyzed in river water and in edible fish...
June 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28639075/does-clavicular-shortening-after-nonoperative-treatment-of-midshaft-fractures-affect-shoulder-function-a-systematic-review
#7
Sarah Woltz, Alysia Sengab, Pieta Krijnen, Inger B Schipper
INTRODUCTION: Clavicular shortening due to non-anatomical healing of displaced clavicular fractures is believed to have a negative effect on shoulder function after recovery. The evidence for this, however, is equivocal. This review aimed to systematically evaluate the available literature to determine whether the current beliefs about clavicular shortening can be substantiated. MATERIALS AND METHODS: This systematic review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement...
June 21, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28638154/-assessment-of-predictive-dermal-exposure-to-chemicals-in-the-work-environment
#8
Agnieszka Jankowska, Sławomir Czerczak, Małgorzata Kupczewska-Dobecka
Assessment of dermal exposure to chemicals in the work environment is problematic, mainly as a result of the lack of measurement data on occupational exposure to chemicals. Due to common prevalence of occupational skin exposure and its health consequences it is necessary to look for efficient solutions allowing for reliable exposure assessment. The aim of the study is to present predictive models used to assess non-measured dermal exposure, as well as to acquaint Polish users with the principles of the selected model functioning...
June 14, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28632664/outcome-of-low-intensity-pulsed-ultrasound-lipus-for-opening-wedge-high-tibial-osteotomy
#9
Ryusuke Saito, Tsuyoshi Nagase, Tomohiko Tateishi, Sadanori Shimizu, Takuya Kato, Teruhiko Nakagawa, Masamitsu Tsutiya
OBJECTIVE: Opening Wedge High Tibial Osteotomy (OWHTO) for knee osteoarthritis and for osteonecrosis has reported good results. Use of low intensity pulsed ultrasound (LIPUS) after OWHTO had become an option for the treatment of OWHTO since April 2016. The purpose of this study was to examine whether LIPUS has an accelerating effect on synostosis after OWHTO. MATERIALS AND METHODS: The control subjects were 24 patients with a total of 26 knees (9 male with knees and 15 female with 17 knees treated) treated with OWHTO only...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28632661/efficacy-and-limitations-of-conservative-treatment-for-painful-patella-partita-positioning-of-an-ultrasound-accelerated-fracture-healing-apparatus
#10
Natsuki Sugimura, Daisuke Hirose, Koji Aso, Masashi Izumi, Yusuke Okanoue, Kazuo Kitaoka, Masahiko Ikeuchi
OBJECTIVE: Generally, painful patella partita is conservatively treated, but the usefulness of a low-intensity pulsed ultrasound (LIPUS) healing apparatus is unclear. The objective of this study was to investigate the usefulness of LIPUS for conservative treatment of painful patella partita. SUBJECTS AND METHODS: The subjects included 17 patients diagnosed with painful patella partita. The subjects were divided into 2 groups: those without pain at 6 months (responsive group) and those with pain that persisted for 6 months or longer (non-responsive group)...
July 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28630649/a-complete-duplication-of-x-chromosome-resulting-in-a-tricentric-isochromosome-originated-by-centromere-repositioning
#11
N Villa, D Conconi, D Gambel Benussi, G Tornese, F Crosti, E Sala, L Dalprà, V Pecile
BACKGROUND: Neocentromeres are rare and considered chromosomal aberrations, because a non-centromeric region evolves in an active centromere by mutation. The literature reported several structural anomalies of X chromosome and they influence the female reproductive capacity or are associated to Turner syndrome in the presence of monosomy X cell line. CASE PRESENTATION: We report a case of chromosome X complex rearrangement found in a prenatal diagnosis. The fetal karyotype showed a mosaicism with a 45,X cell line and a 46 chromosomes second line with a big marker, instead of a sex chromosome...
2017: Molecular Cytogenetics
https://www.readbyqxmd.com/read/28627317/the-european-system-for-the-control-of-the-safety-of-food-contact-materials-needs-restructuring-a-review-and-outlook-for-discussion
#12
Koni Grob
The present European system to assure the safety of migrates from food-contact materials (FCMs) needs improvement. It is proposed to implement better the self-control by the producers through improved official control and more attractive listing of approved substances and materials (the latter being subject of another discussion paper). The initial concept of a positive list for the substances used, a limit for the overall migration and regulation of compliance testing was recognised as insufficient long ago, as it does not properly cover reaction products (including oligomers) and impurities...
June 19, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28625240/-dynamic-changes-of-complement-level-in-patients-with-acute-coronary-syndrome-and-its-relationships-with-myocardial-injury
#13
Aihong Shao, Xin Qi, Qi Li, Wenjun Jia, Liping Wei, Wenguang Hou, Yanfang Qi, Yue Liu
OBJECTIVE: To study relationships between myocardial injury and the levels of serum complement C3, C4 and C5b-9 in patients with acute coronary syndrome (ACS). METHODS: A retrospectively analysis was conducted. 170 ACS patients [including 110 cases of ST-segment elevation myocardial infarction (STEMI) and 60 cases of non-ST-segment elevation acute coronary syndrome (NSTE-ACS)] with ischemic chest pain or chest discomfort onset within the prior 12 hours admitted to the cardiology department of Tianjin Union Medicine Center from January 2014 to July 2016 were enrolled...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28623470/reconstruction-of-aaos-type-iii-and-iv-acetabular-defects-with-the-ganz-reinforcement-ring-high-failure-in-pelvic-discontinuity
#14
Cynthia Hourscht, Mohammad K Abdelnasser, Sufian S Ahmad, Lukas Kraler, Marius J Keel, Klaus A Siebenrock, Frank M Klenke
BACKGROUND: Large acetabular defects and pelvic discontinuity represent complex problems in revision total hip arthroplasty. This study aimed to investigate whether reconstruction with the Ganz reinforcement ring would provide durable function in large acetabular defects. PATIENTS AND METHODS: 46 hips (45 patients, 19 male, 26 female, mean age 68 years) with AAOS type III and IV defects undergoing acetabular revision with the Ganz reinforcement ring were evaluated at a mean follow-up of 74 months (24-161 months)...
June 16, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28622604/tissue-engineered-hypertrophic-chondrocyte-grafts-enhanced-long-bone-repair
#15
Jonathan Bernhard, James Ferguson, Bernhard Rieder, Patrick Heimel, Thomas Nau, Stefan Tangl, Heinz Redl, Gordana Vunjak-Novakovic
Bone has innate ability to regenerate following injury. However, large and complex fractures exceed bone's natural repair capacity and result in non-unions, requiring external intervention to facilitate regeneration. One potential treatment solution, tissue-engineered bone grafts, has been dominated by recapitulating intramembranous ossification (bone formation by osteoblasts), although most serious bone injuries heal by endochondral ossification (bone formation by remodeling of hypertrophic cartilaginous anlage)...
September 2017: Biomaterials
https://www.readbyqxmd.com/read/28622182/reflux-associated-cholecystopathy-analysis-of-76-gallbladders-from-patients-with-supra-oddi-union-of-the-pancreatic-duct-and-common-bile-duct-pancreatobiliary-maljunction-elucidates-a-specific-diagnostic-pattern-of-mucosal-hyperplasia-as-a-prelude-to-carcinoma
#16
Takashi Muraki, Bahar Memis, Michelle D Reid, Takeshi Uehara, Tetsuya Ito, Osamu Hasebe, Shinji Okaniwa, Naoto Horigome, Takeshi Hisa, Pardeep Mittal, Alexa Freedman, Shishir Maithel, Juan M Sarmiento, Alyssa Krasinskas, Jill Koshiol, Volkan Adsay
Pancreaticobiliary maljunction (PBM) is the anomalous union of the main pancreatic duct and common bile duct outside the Oddi-sphincter, allowing the reflux of pancreatic juice to the gallbladder. There is only limited awareness and understanding of the pathologic correlates of this condition, mostly from Japan; this entity is largely unrecognized in the West. In this study, 76 gallbladders from patients with PBM (64 from Japan; 12 from the United States) were analyzed and contrasted with 66 from non-PBM patients...
June 15, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28620592/the-role-of-fibular-fixation-in-the-treatment-of-combined-distal-tibia-and-fibula-fracture-a-randomized-control-trial
#17
Mohammad Javdan, Mohammad Ali Tahririan, Morteza Nouri
BACKGROUND: This randomized, parallel-group, non-blinded study was designed to determine the role of fibular fixation in the treatment outcomes of combined distal tibia and fibula fractures. MATERIALS AND METHODS: Sixty patients with distal tibial and fibular fractures were randomly divided in two groups of case and controls. In the case group, fibula was fixed prior to the fixation of tibia. In the control group, tibia was fixed without fibular fixation. Primary outcomes were varus-valgus angulation, anterior-posterior angulation, union and side effects...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28611307/review-oncolytic-virotherapy-updates-and-future-directions
#18
REVIEW
Christos Fountzilas, Sukeshi Patel, Devalingam Mahalingam
Oncolytic viruses (OVs) are viral strains that can infect and kill malignant cells while spare their normal counterparts. OVs can access cells through binding to receptors on their surface or through fusion with the plasma membrane and establish a lytic cycle in tumors, while leaving normal tissue essentially unharmed. Multiple viruses have been investigated in humans for the past century. IMLYGIC™ (T-VEC/Talimogene Laherparepvec), a genetically engineered Herpes Simplex Virus, is the first OV approved for use in the United States and the European Union for patients with locally advanced or non-resectable melanoma...
May 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28611291/evaluation-of-the-7th-and-8th-editions-of-the-ajcc-uicc-tnm-staging-systems-for-lung-cancer-in-a-large-north-american-cohort
#19
Lin Yang, Shidan Wang, Yunyun Zhou, Sunny Lai, Guanghua Xiao, Adi Gazdar, Yang Xie
PURPOSE: The new 8th American Joint Committee on Cancer (AJCC)/International Union for Cancer Control (UICC) lung cancer staging system was developed and internally validated using the International Association for the Study of Lung Cancer (IASLC) database, but external validation is needed. The goal of this study is to validate the discriminatory ability and prognostic performance of this new staging system in a larger, independent non-small cell lung cancer (NSCLC) cohort with greater emphasis on North American patients...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28610776/two-stage-late-reconstruction-with-a-fresh-large-osteochondral-shell-allograft-transplantation-flocsat-for-a-large-ostechondral-defect-in-a-non-union-after-a-lateral-tibia-plateau-fracture-2-year-follow-up
#20
C Krettek, J Clausen, M Omar, S Noack, C Neunaber
This is the description of a 58-year-old female patient presenting 8 months after a horse riding accident with significant pain and inability to walk independently. Imaging revealed a large osseous defect of the lateral tibia plateau which was not united posteriorly. The patient refused knee replacement and we developed a patient specific two-step procedure for her. Step 1: Filling of the defect with a large cortico-cancellous autograft from the posterior iliac crest; step 2: Transplantation of a fresh large osteochondral shell allograft (FLOCSAT)...
May 17, 2017: Injury
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