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Ocular oncology

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https://www.readbyqxmd.com/read/29677240/uveal-effusion-after-immune-checkpoint-inhibitor-therapy
#1
Merina Thomas, Stephen T Armenti, M Bernadete Ayres, Hakan Demirci
Importance: Immune checkpoint inhibitors, including antiprogrammed cell death protein-1 (anti-PD-1) and antiprogrammed cell death ligand-1 (anti-PD-L1) monoclonal antibodies, have recently been introduced as a promising new immunotherapy for solid cancers. The adverse effects typically include inflammation of the skin, endocrine, and gastrointestinal systems. Objective: To describe 3 patients who developed uveal effusion after initiating anti-PD-1 and anti-PD-L1 monoclonal antibody therapy...
April 12, 2018: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29607824/lymphoid-proliferation-in-eyelid-a-primary-follicular-lymphoma-case
#2
Deivy Cruzado-Sánchez, Walter Andree Tellez, Solon Serpa-Frias, Grisnery Maquera
Ocular adnexal lymphoma (OAL) constitutes 8% of all extranodal lymphomas, being rare in the eyelids (5-20%). The objective was to report a case of eyelid follicular lymphoma in a young adult woman. A 35-year-old female with swelling in left lower eyelid with development for 2 months. The visual acuity was 20/20 in both eyes, the tumor mass was 3 cm wide and 1.5 cm long. The contrast-enhanced computed tomography showed a soft-tissue injury in the left lower eyelid but had no signs of local spread according to description...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29582943/-advances-in-the-treatment-of-retinoblastoma-at-hadassah-in-the-last-three-decades
#3
Shahar Frenkel, Michael Weintraub, Ido Rot, Naomi Shoshani, Jacob Pe'er
INTRODUCTION: Retinoblastoma (RB) is a malignant tumor presenting in the eyes of infants and children, which endangers life, the eye and vision. The treatment of RB has undergone marked changes in recent years, and great progress has been made in our ability to preserve eyes. Over the last three decades most Israeli patients with RB have been treated in the National Specialty Ocular Oncology Service at the Hadassah-Hebrew University Medical Center in Jerusalem. AIMS: To describe advances in the primary treatment of RB with an emphasis on eye-preserving treatments...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29578940/relationship-of-clinical-features-and-baseline-tumor-size-with-gene-expression-profile-status-in-uveal-melanoma-a-multi-institutional-study
#4
Duncan Berry, Michael Seider, Sandra Stinnett, Prithvi Mruthyunjaya, Amy C Schefler
PURPOSE: To study the relationship between gene expression profile subclass and clinical features in a multicenter cohort of patients with uveal melanoma. METHODS: A retrospective, multicenter study was undertaken with patients entered from nine major ocular oncology centers from across the United States. Eligible patients had uveal melanoma and underwent I-125 plaque brachytherapy with concurrent tumor biopsy with gene expression profile testing between January 1, 2010, and October 28, 2014...
March 23, 2018: Retina
https://www.readbyqxmd.com/read/29529957/circulating-cell-free-dna-does-not-harbour-a-diagnostic-benefit-in-cats-with-feline-diffuse-iris-melanomas
#5
Jessica G Rushton, Reinhard Ertl, Dieter Klein, Alexander Tichy, Barbara Nell
Objectives Feline diffuse iris melanoma (FDIM) is the most common malignant primary intraocular tumour in cats, with reported metastases rates between 19% and 63%. Currently, the only available diagnostic tool for a tentative diagnosis is histopathological examination of the enucleated eye. Therefore, the veterinary ophthalmologist is often faced with the dilemma of whether to enucleate an oftentimes visual eye or to continue monitoring, with the risk of metastases developing. In the past, cell-free DNA (cfDNA) gained more attention in human medicine, especially in the field of oncology...
March 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29517495/hydroxychloroquine-balancing-the-need-to-maintain-therapeutic-levels-with-ocular-safety-an-update
#6
Nada Abdulaziz, Anjali R Shah, William J McCune
PURPOSE OF REVIEW: Antimalarial drugs including chloroquine, its less toxic quinolone-derivative hydroxychloroquine (HCQ), and quinacrine have become cornerstones in the treatment of autoimmune diseases including systemic lupus, rheumatoid arthritis, sarcoidosis, and Sjogren syndrome; cutaneous disorders, antiphospholipid syndrome, and have recently been employed at higher dioses in oncology. Benefits include anti-inflammatory effects, protection against thrombosis, and improved control of hyperglycemia and hyperlipidemia...
May 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29484864/-development-and-challenges-in-treatment-of-uveal-melanoma
#7
REVIEW
Ofira Zloto, Vicktoria Vishnevskia-Dai, Joseph Moisseiev, Ido Didi Fabian
Uveal melanoma, the most common primary intraocular malignancy in adults, is potentially a lethal tumour. Since the development of local radiotherapy, tumour control is achieved in the majority of cases and most eyes are salvaged. Despite this, more than 50% of patients develop distant metastatic spread, mainly to the liver, and in the absence of efficient treatments to extend life, die soon after. A great deal of effort has been put into developing prognostic markers for metastatic spread and survival. Novel genetic prognostic tests, recently introduced, are now being clinically used in many ocular oncology centres worldwide...
February 2018: Harefuah
https://www.readbyqxmd.com/read/29478423/early-detection-and-successful-treatment-of-wernicke-s-encephalopathy-in-outpatients-without-the-complete-classic-triad-of-symptoms-who-attended-a-psycho-oncology-clinic
#8
Hideki Onishi, Mayumi Ishida, Iori Tanahashi, Takao Takahashi, Kenji Ikebuchi, Yoshitada Taji, Hisashi Kato, Tatsuo Akechi
OBJECTIVE: Wernicke's encephalopathy (WE) is a neuropsychiatric disorder caused by a thiamine deficiency. Although WE has been recognized in cancer patients, it can be overlooked because many patients do not exhibit symptoms that are typical of WE, such as delirium, ataxia, or ocular palsy. Furthermore, outpatients with WE who intermittently present at psycho-oncology clinics have not been described as far as we can ascertain. METHOD: This report describes two patients who did not exhibit the complete classic triad of symptoms among a series with cancer and WE, and who attended a psycho-oncology outpatient clinic...
February 26, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29465436/orbital-exenteration-for-sinonasal-malignancies-indications-rehabilitation-and-oncologic-outcomes
#9
José G Vartanian, Ronaldo N Toledo, Thiago Bueno, Luiz P Kowalski
PURPOSE OF REVIEW: Review the recent literature regarding the management of orbital invasion in sinonasal malignant tumors. RECENT FINDINGS: There is a recent trend in preserving the orbit in cases of minimal invasion of periosteum and limited periorbit involvement, as well as in presence of good response to neoadjuvant chemotherapy, mainly in squamous cell carcinoma and neuroendocrine histologies. SUMMARY: The decision about orbital exenteration in cases of sinonasal malignancies is facilitated if the patient already has clear clinical signs of intraconal invasion such as visual loss, restriction of ocular mobility or infiltration of the eyeglobe...
April 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29414877/photodynamic-therapy-in-ocular-oncology
#10
REVIEW
Maria Antonietta Blasi, Monica Maria Pagliara, Angela Lanza, Maria Grazia Sammarco, Carmela Grazia Caputo, Gabriela Grimaldi, Andrea Scupola
Although introduced for the treatment of maculopathies, photodynamic therapy (PDT) is now largely used in some eye cancers treatment. The selective tissue damage with PDT is achieved by sequestration of the photosensitizer in the target tissue and focal activation of the photosensitizer by low energy directed light. In this way, it is possible to achieve the destruction of the tumor tissue by safeguarding the surrounding healthy structures. Our study describes the clinical uses and efficacy of photodynamic therapy in ocular oncology...
February 7, 2018: Biomedicines
https://www.readbyqxmd.com/read/29378070/from-the-cover-inhibitors-of-nicotinamide-phosphoribosyltransferase-cause-retinal-damage-in-larval-zebrafish
#11
Steven Cassar, Christina Dunn, Amanda Olson, Wayne Buck, Stacey Fossey, Meg Ferrell Ramos, Pankajkumar Sancheti, DeAnne Stolarik, Heather Britton, Todd Cole, Natalie Bratcher, Xin Huang, Richard Peterson, Kenton Longenecker, Bruce LeRoy
Nicotinamide phosphoribosyltransferase (NAMPT) has been investigated as a target for oncology because it catalyzes a rate-limiting step in cellular energy metabolism to produce nicotinamide adenine dinucleotide. Small molecule inhibitors of NAMPT have been promising drug candidates but preclinical development has been hindered due to associated retinal toxicity. Here we demonstrate that larval zebrafish can predict retinal toxicity associated with this mechanism revealing an attractive alternative method for identifying such toxicities...
February 1, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29376097/xeroderma-pigmentosum-is-a-definite-cause-of-huntington-s-disease-like-syndrome
#12
Hector Garcia-Moreno, Hiva Fassihi, Robert P E Sarkany, Julie Phukan, Thomas Warner, Alan R Lehmann, Paola Giunti
Xeroderma pigmentosum is characterized by cutaneous, ophthalmological, and neurological features. Although it is typical of childhood, late presentations can mimic different neurodegenerative conditions. We report two families presenting as Huntington's disease-like syndromes. The first case (group G) presented with neuropsychiatric features, cognitive decline and chorea. Typical lentigines were only noticed after the neurological disease started. The second case (group B) presented adult-onset chorea and neuropsychiatric symptoms after an aggressive ocular melanoma...
January 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29321667/the-management-of-retinoblastoma
#13
REVIEW
Ido D Fabian, Zerrin Onadim, Esin Karaa, Catriona Duncan, Tanzina Chowdhury, Irene Scheimberg, Shin-Ichi Ohnuma, M Ashwin Reddy, Mandeep S Sagoo
Retinoblastoma (Rb) is the most common primary intraocular malignancy of childhood, but an uncommon paediatric cancer, with a constant incidence worldwide of 1:15,000-1:20,000 live births. Despite its rarity, Rb has served as a cornerstone in the field of oncology in many of the aspects that comprise cancer management, including classification schemes, treatment modalities, genetic testing and screening. Until just over half a century ago, the major treatment for Rb was eye removal, and prognosis was poor with outcome fatal for most children...
March 2018: Oncogene
https://www.readbyqxmd.com/read/29313397/detection-of-extrascleral-extension-in-uveal-melanoma-with-histopathological-correlation
#14
Christopher K H Burris, Vasilios P Papastefanou, Caroline Thaung, Marie Restori, Amit K Arora, Mandeep S Sagoo, Victoria M L Cohen
PURPOSE: Uveal melanoma is the most common primary intraocular malignancy. Extrascleral extension (ESE) is rare, but associated with an increased rate of orbital recurrence and an overall poor prognosis. Clinical studies show low rates when compared with histological studies. Due to the prognostic importance of ESE, we sought to compare our clinical, intraoperative, and histological detection rates. DESIGN: A retrospective cross-sectional case series. METHODS: A list of eyes enucleated for uveal melanoma was compiled from the admissions records of the London Ocular Oncology Service during the 28-month period, i...
January 9, 2018: Orbit
https://www.readbyqxmd.com/read/29122819/treatment-of-conjunctival-melanoma-in-a-dutch-referral-centre
#15
Niels J Brouwer, Marina Marinkovic, Sjoerd G van Duinen, Jaco C Bleeker, Martine J Jager, Gregorius P M Luyten
AIMS: To evaluate the treatment of conjunctival melanoma at a large Dutch referral centre and to make recommendations for clinical management. METHODS: A retrospective review was performed of clinical and histological data of 70 patients treated for a primary conjunctival melanoma between 2001 and 2014 at the Leiden University Medical Center, Leiden, the Netherlands. Detailed follow-up data were available for all patients. RESULTS: The mean follow-up time was 70...
November 9, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29121185/molecular-characteristics-of-conjunctival-melanoma-using-whole-exome-sequencing
#16
Swarup S Swaminathan, Matthew G Field, David Sant, Gaofeng Wang, Anat Galor, Sander R Dubovy, J William Harbour, Carol L Karp
Importance: Conjunctival melanoma (CM) is a highly aggressive ocular cancer for which treatment options are limited; the molecular pathogenesis is poorly understood. Objective: To identify the molecular characteristics of CM using next-generation whole-exome sequencing (WES). Design, Setting, and Participants: Whole-exome sequencing was performed on tumor DNA extracted from the archived specimens of 5 patients with CM who had been treated with surgical excision between 2006 and 2011...
December 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29110121/-nanoparticles-as-drug-delivery-systems-in-ophthalmology
#17
REVIEW
M Löscher, J Hurst, L Strudel, M S Spitzer, S Schnichels
Nanoparticles are perfectly suited as drug delivery systems due to their size and the diversity of materials used. They are able to penetrate biological barriers, can directly deliver drugs to the target site and provide a sustained release profile. Having long been established in oncology, in the last decade research has started to take a closer look at the potential of nanoparticles for ocular drug delivery. Obstacles, such as poor delivery of drugs via eye drops and the side effects of invasive methods, such as placing implants as drug depots could be overcome...
November 6, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29074262/photodynamic-therapy-as-initial-treatment-for-small-choroidal-melanomas
#18
F Jmor, R N Hussain, B E Damato, H Heimann
PURPOSE: To evaluate Verteporfin photodynamic therapy (PDT) as primary treatment for small, posterior choroidal melanoma. DESIGN: Retrospective cohort review. SUBJECTS, PARTICIPANTS AND CONTROLS: Retrospective case note review of 20 patients with small juxtapapillary and juxtafoveal choroidal melanomas treated with PDT at the Liverpool Ocular Oncology Clinic. METHODS: Patient and tumour characteristics, PDT session details, visual acuity and B-scan ultrasonography measurements as well as colour fundus photographs at each examination were collated and analysed...
December 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29051324/corneal-complications-after-orbital-radiotherapy-for-primary-epithelial-malignancies-of-the-lacrimal-gland
#19
Sri K Gore, Nicholas P Plowman, Aruna Dharmasena, David H Verity, Geoffrey E Rose
PURPOSE: To review the long-term corneal complications after high-dose external beam orbital radiotherapy given to patients for lacrimal gland carcinomas. The impact of prophylactic measures to improve long-term ocular surface health is also assessed. DESIGN: Retrospective case series. PARTICIPANTS: Patients under the care of Moorfields Eye Hospital and receiving external beam radiotherapy for primary epithelial lacrimal gland carcinoma between 1975 and 2014...
October 19, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29039988/the-intraoperative-use-of-polydioxanone-foil-to-reduce-the-risk-of-sino-orbital-fistula-formation-in-orbital-exenteration
#20
Aws Al-Hity, Maria Elena Gregory, Ewan G Kemp
BACKGROUND: Orbital exenteration is a radical surgical procedure resulting in deformity. It involves removal of the globe, optic nerve, extra-ocular muscles, orbital fat, lacrimal gland, and peri-osteum. Sino-orbital fistula (SOF) formation is a common documented post-operative complication, usually connecting the orbit and the ethmoid sinus. SOFs can cause leaks of serous fluid, and act as an entry site for pathogens into the orbit leading to socket infection and breakdown. METHODS: This retrospective study analyzed exenterations performed over a 22-year period (1993-2015) at the National Ocular Oncology Service Centre for Scotland...
October 17, 2017: Orbit
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