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Ocular oncology

V Kakkassery, K U Loeffler, M Sand, K R Koch, A M Lentzsch, A C Nick, I A Adamietz, L M Heindl
The treatment options for basal cell carcinoma (BCC) have recently been augmented with the introduction of novel chemotherapeutic drugs. New S2 guidelines on the disease have also been published. The aim of this article is to present a comprehensive state of the art description of the features of ocular BCC and an overview of the various therapeutic options. Particular emphasis is placed on the clinical signs, the diagnostic tools to identify periocular BCC and interpretation of the different histopathological subtypes...
October 17, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Carol L Shields, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Alexzandra M Douglass, Kareem Sioufi, Emil A T Say, Jerry A Shields
PURPOSE: To evaluate frequency of conjunctival tumors in all ages and compare benign versus (vs) malignant counterparts. DESIGN: Retrospective series. METHODS: Setting: Tertiary referral center STUDY POPULATION: 5002 patients OBSERVATION: Clinical features MAIN OUTCOME MEASURE: Differentiation benign from malignant counterparts RESULTS: The tumor was benign (52%), premalignant (18%), or malignant (30%). Malignant tumors included melanoma (12%), squamous cell carcinoma (9%), lymphoma (7%), and others...
October 7, 2016: American Journal of Ophthalmology
Kirollos S Hanna
PURPOSE: Pembrolizumab, a programmed cell death protein 1 (PD-1) inhibitor, is a humanized monoclonal antibody used in the treatment of metastatic or unresectable melanoma and advanced non-small cell lung cancer (NSCLC). We hereby report a case of pembrolizumab-induced uveitis to increase practitioner awareness. CASE REPORT: A 78-year-old female presented with onset of panuveitis after initiation of pembrolizumab therapy for metastatic melanoma. The patient received three cycles of therapy every 21 days during which her symptoms progressively worsened...
September 26, 2016: Pharmacotherapy
Bilal Sula, Feyzullah Uçmak, Mehmet Ali Kaplan, Zuhat Urakçi, Mustafa Arica, Abdurrahman Isikdogan
INTRODUCTION: The present study aimed to establish the epidemiological and clinical characteristics of patients who were histopathologically diagnosed with malignant melanoma (MM). METHODS: The present study retrospectively analyzed the data of 78 patients who were histopathologically diagnosed with MM in Dicle University Medical Faculty, Dermatology and Medical Oncology departments between 2005 and 2014. RESULTS: The study included 78 patients in total with 44 (56...
2016: Pan African Medical Journal
Renu Dhasmana, Amrita Prakash, Neeti Gupta, S K Verma
OBJECTIVES: To study the ocular manifestations in patients diagnosed with leukemia or myeloproliferative disorders and to derive an association between the ocular manifestations and hematological parameters of the patients. MATERIALS AND METHODS: This observational and descriptive study was conducted in a Tertiary Care Center of Dehradun, North India over a period of 1 year. All the diagnosed cases of leukemia and myeloproliferative diseases attending the Oncology Department were included...
July 2016: Annals of African Medicine
Edwina Eade, Krishna Tumuluri, Helen Do, Neil Rowe, James Smith
BACKGROUND: Orbital rhabdomyosarcoma is a rare but important malignancy for an ophthalmologist. We aimed to review the management and outcome, including late orbital complications and visual acuity over 25 years from a specialist paediatric ophthalmology department. DESIGN: This was a retrospective longitudinal case-series. PARTICIPANTS: All patients presenting to our institution between December 1989 and December 2014 with a histopathological diagnosis of rhabdomyosarcoma originating from (primary) or invading into the orbit (paranasal) were included...
July 29, 2016: Clinical & Experimental Ophthalmology
Ido Didi Fabian, G Darius Hildebrand, Shaun Wilson, Tina Foord, Mandeep S Sagoo
BACKGROUND: Intraocular iris rhabdomyosarcoma is extremely rare, and in the 3 cases reported to date occurred as the primary site of tumour growth. We report a case of rhabdomyosarcoma of the foot metastasizing to the iris. CASE PRESENTATION: An 18-year-old white female was referred to the London Ocular Oncology Service for management of a metastatic rhabdomyosarcomatous deposit in the iris, a metastasis from alveolar rhabdomyosarcoma of the foot. She was diagnosed nearly 2 years earlier with the primary sarcoma with extensive systemic spread and treated by resection of the foot lesion and chemotherapy, and achieved a partial remission...
2016: BMC Cancer
Tero T Kivelä, Sophie Piperno-Neumann, Laurence Desjardins, Alexander Schmittel, Nikolaos Bechrakis, Edoardo Midena, Serge Leyvraz, Leonidas Zografos, Jean-Daniel Grange, Guillaume Ract-Madoux, Ernest Marshall, Bertil Damato, Sebastian Eskelin
PURPOSE: To validate a staging system for metastatic uveal melanoma that will facilitate planning, reporting, and interpreting the results of clinical trials. DESIGN: Reliability and validity study. METHODS: The performance index, the largest diameter of the largest metastasis and alkaline phosphatase level at the time of diagnosis of metastases, and overall survival of 249 patients from 7 ocular oncology centers who died of dissemination were analyzed...
August 2016: American Journal of Ophthalmology
José Luis D'Addino, Laura Piccoletti, María Mercedes Pigni, Maria José Rodriguez Arenas de Gordon
The objective of this study is to report a large, rare, and ulcerative infiltrated skin lesion. Its diagnosis, therapeutic management, and progress are described. The patient is a 78-year-old white man, who presented with a 12-month ulcerative perforated lesion that had affected and infiltrated the skin, with easy bleeding. He had a history of hypertension, although controlled, was a 40-year smoker, had chronic atrial fibrillation, diabetes, and microangiopathy. During the consultation, the patient also presented with ocular obstruction due to an inability to open the eye...
June 2016: Craniomaxillofacial Trauma & Reconstruction
P R Arany
The fundamental pathophysiologic response for the survival of all organisms is the process of wound healing. Inadequate or lack of healing constitutes the etiopathologic basis of many oral and systemic diseases. Among the numerous efforts to promote wound healing, biophotonics therapies have shown much promise. Advances in photonic technologies and a better understanding of light-tissue interactions, from parallel biophotonics fields such as in vivo optical imaging and optogenetics, are spearheading their popularity in biology and medicine...
August 2016: Journal of Dental Research
Joëlle Antoun, Cherif Titah, Isabelle Cochereau
PURPOSE OF REVIEW: Checkpoint inhibitors have been increasingly considered as new targets for cancer therapies. Patients receiving checkpoint inhibitors develop many immune-related adverse events (IRAEs). However, ophthalmic IRAEs are rare and have been reported in less than 1% of patients. To date, few case reports evaluating the ophthalmological side-effects of checkpoint inhibitors have been published. In this review, we plan to report the different ocular and orbital side-effects of the checkpoint inhibitors, and to help guide ophthalmologists and oncologists in their management...
July 2016: Current Opinion in Oncology
Quentin Lisan, Frédéric Kolb, Stéphane Temam, Yungan Tao, François Janot, Antoine Moya-Plana
BACKGROUND: Indications for preservation of orbital contents in case of malignant sinonasal tumors invading the orbit remain controversial. METHODS: A retrospective consecutive review was conducted of patients in a tertiary care center over a 15-year period. RESULTS: Ninety-three patients were diagnosed with a malignant tumor invading the orbit. Eighty-three were treated with curative intent of which 58 underwent surgery. Mean follow-up was 45 months...
April 30, 2016: Head & Neck
Scott D Walter, Daniel L Chao, William Feuer, Joyce Schiffman, Devron H Char, J William Harbour
IMPORTANCE: Uveal melanoma (UM) can be divided into prognostically significant subgroups based on a prospectively validated and widely used 15-gene expression profile (GEP) test. Class 1 UMs have a low risk and class 2 UMs have a high risk for metastasis. OBJECTIVE: To determine whether any clinicopathologic factors provide independent prognostic information that may enhance the accuracy of the GEP classification. DESIGN, SETTING, AND PARTICIPANTS: This retrospective observational study performed at 2 ocular oncology referral centers included 339 patients in a primary cohort and 241 patients in a validation cohort...
July 1, 2016: JAMA Ophthalmology
Yamini Krishna, Helen Kalirai, Sophie Thornton, Bertil E Damato, Heinrich Heimann, Sarah E Coupland
BACKGROUND/AIMS: Iris melanomas (IM) are rare and have a lower mortality than posterior uveal melanomas (UM). Our aims were to determine the prevalence of genetic changes associated with prognosis of posterior UM, in both treated and non-treated IM. METHODS: Retrospective database review and molecular analysis of all patients diagnosed with IM at the Liverpool Ocular Oncology Centre (LOOC) between 1993 and 2015. Archival pathology specimens of confirmed IM cases were analysed for chromosomal alterations, using multiplex ligation-dependent probe amplification (MLPA) or microsatellite analysis (MSA) depending on DNA yield, and BRAF mutation status...
April 20, 2016: British Journal of Ophthalmology
Simone G A Selistre, Marcelo K Maestri, Patricia Santos-Silva, Lavinia Schüler-Faccini, Luis S P Guimarães, Juliana Giacomazzi, Mario C Evangelista Júnior, Patricia Ashton-Prolla
BACKGROUND: Retinoblastoma (Rb) is the most common intraocular tumor diagnosed in children in Brazil. However, detailed information is lacking regarding patient clinical demographics. This study aimed to determine the clinical profile of patients with Rb who were treated in a public university hospital in southern Brazil from 1983 to 2012. METHODS: Patients' medical records were reviewed to retrospectively identify patients with a principal diagnosis of Rb. Rb was classified as hereditary or non-hereditary...
2016: BMC Pediatrics
Kaustubh Mulay, Santosh G Honavar
Ocular adnexal lymphoma (OAL) is a relatively common lesion in the practice of ophthalmic oncology. Although OALs are usually primary tumors, secondary involvement of the ocular adnexae by systemic lymphoma is also possible. The clinical and radiological features of OAL are non-specific. Thorough morphological evaluation, aided by immunostaining, cytogenetic studies and molecular testing, are necessary for accurate diagnosis.
May 2016: Seminars in Diagnostic Pathology
Jing Li, Jian-Min Ma, Xin Ge
AIM: To explore the role of IgG4 serology in identifying common orbital lymphoproliferative disorders. METHODS: Eighty-one patients with orbital lymphoproliferative diseases were treated in the Department of Ocular Oncology, Beijing Tongren Hospital, Capital Medical University between September 2010 and December 2012. Serum IgG4 levels were measured in 46 cases of idiopathic orbital inflammatory pseudotumor (IOIP), 17 benign lymphoepithelial lesion (BLEL), 12 cases of orbital mucosa-associated lymphoid tissue (MALT), and 6 cases of diffuse large B-cell lymphoma (DLBL) using immuno-scatter turbidmetry (ISTM)...
2016: International Journal of Ophthalmology
V Verma, M P Mehta
AIMS: Although clinical experience with proton beam radiotherapy (PBT) for most tumours is limited, there is relatively longstanding experience for uveal melanomas. Because of potential to reduce ocular toxicities, PBT is an attractive option for these tumours. However, summative data remain scarce. We systematically reviewed clinical outcomes of uveal melanoma patients treated with PBT, to comprehensively assess outcomes such as tumour control, survival, enucleation rates, toxicity and visual acuity preservation...
August 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Mary Elizabeth Davis
PURPOSE/OBJECTIVES: To review common tyrosine kinase inhibitors, as well as their ocular side effects and management.
. DATA SOURCES: A comprehensive literature search was conducted using CINAHL®, PubMed, and Cochrane databases for articles published since 2004 with the following search terms. DATA SYNTHESIS: Tyrosine kinase inhibitors can cause significant eye toxicity.
. CONCLUSIONS: Given the prevalence of new tyrosine kinase inhibitor therapies and the complexity of possible pathogenesis of ocular pathology, oncology nurses can appreciate the occurrence of ocular toxicities and the role of nursing in the management of these problems...
March 2016: Oncology Nursing Forum
Ioannis N Mammas, Anne Greenough, Maria Theodoridou, Anna Kramvis, Iliana Christaki, Chryssie Koutsaftiki, Maria Koutsaki, Dimitra M Portaliou, Georgia Kostagianni, Paraskevi Panagopoulou, George Sourvinos, Demetrios A Spandidos
Paediatric Virology is a bold new scientific field, which combines Paediatrics with Virology, Epidemiology, Molecular Medicine, Evidence-based Medicine, Clinical Governance, Quality Improvement, Pharmacology and Immunology. The Workshop on Paediatric Virology, which took place on Saturday October 10, 2015 in Athens, Greece, provided an overview of recent views and advances on viral infections occurring in neonates and children. It was included in the official programme of the 20th World Congress on Advances in Oncology and the 18th International Symposium on Molecular Medicine, which attracted over 500 delegates from the five continents...
January 2016: Experimental and Therapeutic Medicine
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