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https://www.readbyqxmd.com/read/29160156/prestin-as-an-otologic-biomarker-of-cisplatin-ototoxicity-in-a-guinea-pig-model
#1
James Naples, Robert Cox, Gregory Bonaiuto, And Kourosh Parham
Objective To evaluate (1) whether changes in serum prestin aid in early detection of cisplatin ototoxicity, (2) the role of diltiazem as an otoprotectant, and (3) whether prestin levels are sensitive to effects of diltiazem. Study Design Experimental animal study. Setting Translational research laboratory. Subjects Twenty female guinea pigs. Methods Two groups of 10 guinea pigs were used. The relationship between serum prestin levels and auditory brainstem response (ABR) thresholds was compared between the groups...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29153260/diagnostic-criteria-for-patulous-eustachian-tube-a-proposal-by-the-japan-otological-society
#2
Toshimitsu Kobayashi, Masahiro Morita, Satoshi Yoshioka, Kunihiro Mizuta, Shigeto Ohta, Toshiaki Kikuchi, Tatsuya Hayashi, Akihiro Kaneko, Nobumasa Yamaguchi, Sho Hashimoto, Hiromi Kojima, Shingo Murakami, Haruo Takahashi
Patulous Eustachian Tube (PET) is of increasing importance in otology. However, despite the abundance of diseases requiring a differential diagnosis from PET, such as superior semicircular canal dehiscence syndrome, perilymphatic fistula, acute low-tone sensorineural hearing loss, etc., there are currently no established diagnostic criteria for PET. In view of these circumstances, the Japan Otological Society (JOS) Eustachian Tube Committee proposed the diagnostic criteria for Patulous Eustachian Tube in 2012, in order to promote clinical research on PET...
November 15, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29152751/healthcare-disparities-in-pediatric-otolaryngology-a-systematic-review
#3
Jad Jabbour, Thomas Robey, Michael J Cunningham
OBJECTIVES: Multiple studies have reported healthcare disparities in particular settings and conditions within pediatric otolaryngology, but a systematic examination of the breadth of the problem within the field is lacking. This study's objectives are to synthesize the available evidence regarding healthcare disparities in pediatric otolaryngology, highlight recurrent themes with respect to etiologies and manifestations, and demonstrate potential impacts from patient and provider standpoints...
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29151473/prevalence-of-dizziness-and-associated-factors-in-south-korea-a-cross-sectional-survey-from-2010-to-2012
#4
Jiwon Chang, Soon Young Hwang, Su Kyoung Park, Jin Hwan Kim, Hyung-Jong Kim, Sung-Won Chae, Jae-Jun Song
BACKGROUND: Dizziness is one of the most common complaints in medicine and a frequent symptom among older people. Dizziness has a considerable impact on life quality and is associated with high economic costs. The purpose of this study was to evaluate the prevalence of dizziness in the general population and to describe its clinical characteristics and associated factors. METHODS: The Korea National Health and Nutrition Examination Survey (KNHANES) is a cross-sectional survey of the civilian, non-institutionalized population of South Korea...
November 18, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/29151384/endoscopic-ear-surgery-in-the-ear-camp-setting-forward-thinking-or-folly
#5
M P A Clark
BACKGROUND: Endoscopic ear surgery is becoming an accepted technique in otological surgery, in the management of chronic otitis media. METHODS: The technique was introduced to the humanitarian care setting of an ear camp in Nepal to consider the appropriateness of the technique in this type of clinical setting. RESULTS: Fifteen cases of myringoplasty were successfully completed. CONCLUSION: The apparent advantages of the endoscopic approach over the traditional microscopic one were the ease of transporting the equipment and the optimal view obtained of the tympanic membrane...
November 20, 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/29144607/eustachian-tube-dysfunction-symptoms-in-patients-treated-in-a-tertiary-rhinology-clinic
#6
Michael J Marino, Lina Chooi Ling, William C Yao, Amber Luong, Martin J Citardi
BACKGROUND: Ear symptoms are common among patients presenting to a rhinology clinic. Validated inventories are available for patient quality-of-life in sinonasal disease and Eustachian tube dysfunction (ETD). This study sought to determine the extent of ETD symptoms, using validated metrics, in a large population of patients presenting to a tertiary rhinology clinic. METHODS: Seven-item Eustachian Tube Dysfunction Questionnaires (ETDQ-7) and 22-item Sino-Nasal Outcome Tests (SNOT-22) were prospectively collected from 492 patients treated in a tertiary rhinology clinic...
November 16, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29141478/utility-of-quick-oculomotor-tests-for-screening-the-vestibular-system-in-the-subacute-and-chronic-populations
#7
Helen S Cohen, Jasmine Stitz, Haleh Sangi-Haghpeykar, Susan P Williams, Ajitkumar P Mulavara, Brian T Peters, Jacob J Bloomberg
OBJECTIVE: The goal of this study was to determine the sensitivity and specificity of some widely used, easily administered clinical tests. BACKGROUND: Simple tests of oculomotor function have become widely used for clinical screening of patients suspected of having vestibular disorders despite a paucity of evidence showing good statistical support for their use in this highly variable population. METHODS: Healthy controls with no history of otologic or neurologic disorders (n = 291) were compared to patients with known vestibular disorders (n = 62)...
November 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29140966/how-was-your-otology-training-a-survey-of-recent-otolaryngology-residents
#8
Phillip Montague, Donald Bennett, Brian Kellermeyer
OBJECTIVE: To survey graduating residents or recent graduates of otolaryngology residency programs to evaluate their Otology/Neurotology (ON) experience in residency and discern if they had received adequate training in time to decide whether to pursue a fellowship in Otology or Neurotology. STUDY DESIGN: Internet-based survey. METHODS: A survey was distributed to all US otolaryngology residency programs to distribute to 5th year residents and recent graduates in last 4 years...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29135867/analysis-of-otologic-features-of-patients-with-primary-ciliary-dyskinesia
#9
Kazuhiko Takeuchi, Masako Kitano, Hiroshi Sakaida, Satoko Usui, Sawako Masuda, Satoru Ogawa, Makoto Ikejiri, Mizuho Nagao, Takao Fujisawa, Kaname Nakatani
OBJECTIVE: To evaluate otologic features of primary ciliary dyskinesia (PCD), especially eardrum features, audiometric findings, and clinical course. STUDY DESIGN: Retrospective patient review. SETTING: Tertiary referral center. PATIENTS: Fifteen patients (mean age, 16.9 years [range, 1-32 yr]; 8 males and 7 females) diagnosed with PCD at our university hospital in the last 12 years. INTERVENTION: Diagnostic...
December 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29132251/hearing-impairment-is-common-among-saami-adults-in-northern-finland
#10
Venla Lohi, Pasi Ohtonen, Pekka Aikio, Martti Sorri, Elina Mäki-Torkko, Samuli Hannula
The Saami are the only indigenous population in Europe and their traditional living area is northern Scandinavia. Hearing impairment (HI) among Saami has not been studied before. The objective was to investigate the presence and type of HI among Saami adults, aged 49-77 years (median age 61 years), living in northern Finland. In addition, the presence of self-reported hearing difficulties, difficulties to hear in background noise and tinnitus were studied. An epidemiological, cross-sectional study encompassing a structured interview, otological examination and audiometry was performed...
2017: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29130038/nanomedicine-for-inner-ear-diseases-a-review-of-recent-in-vivo-studies
#11
REVIEW
Dong-Kee Kim
Nanoparticles are promising therapeutic options for inner ear disease. In this report, we review in vivo animal studies in the otologic field using nanoparticles over the past 5 years. Many studies have used nanoparticles to deliver drugs, genes, and growth factors, and functional and morphological changes have been observed. The constituents of nanoparticles are also diversifying into various biocompatible materials, including poly(lactic-co-glycolic acid) (PLGA). The safe and effective delivery of drugs or genes in the inner ear will be a breakthrough for the treatment of inner ear diseases, including age-related hearing loss...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29125012/optical-assessment-of-the-in-vivo-tympanic-membrane-status-using-a-handheld-optical-coherence-tomography-based-otoscope
#12
Kibeom Park, Nam Hyun Cho, Mansik Jeon, Sang Heun Lee, Jeong Hun Jang, Stephen A Boppart, Woonggyu Jung, Jeehyun Kim
OBJECTIVE: Conventional otoscopes and oto-endoscopes, which are used to examine the tympanic membrane (TM), do not provide tomographic information. Optical coherence tomography (OCT) non-invasively reveals the depth-resolved internal microstructure of the TM with very high spatial resolution. We designed this study to examine the TMs with middle ear diseases using a handheld otoscope employing 860 nm spectral domain (SD)-OCT, combined with video camera and to demonstrate the clinical applicability of this system...
November 10, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29121384/correlation-between-sensorineural-hearing-loss-and-chronic-otorrhea
#13
Fernanda Martinho Dobrianskyj, Ísis Rocha Gonçalves, Yumi Tamaoki, Edson Ibrahim Mitre, Fernando A Ribeiro
Many studies have attempted to correlate chronic otorrhea in children and in adults with the sensorineural hearing loss in the affected ear, with contradictory results. This loss might be the result of the likely toxicity of the bacteria involved, effects of inflammatory cytokines, or constant use of ototoxic antibiotics. All studies evaluated to date compared the affected ear with the normal contralateral ear. From the digitized archive of otologic surgery files of the Department of Otorhinolaryngology at Santa Casa de São Paulo School of Medical Sciences, the ears of patients with chronic otorrhea were evaluated visually and compared with the normal contralateral ears...
October 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29120919/nystagmus
#14
Alexander A Tarnutzer, Dominik Straumann
PURPOSE OF REVIEW: The clinical and laboratory assessment of nystagmus in patients with neurologic disorders can provide crucial elements for a state-of-the-art differential diagnosis. An increasing number of publications in the fields of neuro-otology and neuro-ophthalmology have nystagmus in the center of interest, which makes frequent updates on the diagnostic and therapeutic relevance of these contributions indispensable. This review covers important clinical studies and studies in basic research relevant for the neurologist published from January 2016 to August 2017...
November 7, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/29111474/the-middle-temporal-artery-surgical-anatomy-and-exposure-for-cerebral-revascularization
#15
Roberto Rodriguez Rubio, Michael T Lawton, Olivia Kola, Halima Tabani, Sonia Yousef, Ali Tayebi Meybodi, Jan-Karl Burkhardt, Ivan El-Sayed, Arnau Benet
BACKGROUND: The middle temporal artery (MTA) is the proximal medial branch of the superficial temporal artery (STA), supplying the temporalis muscle along with deep temporal arteries. Its use in vascularized flaps for reconstructive and otologic procedures has been described, yet its potential use in neurosurgery is not studied. We report a novel technique for exposing the MTA and evaluated its characteristics for extracranial-intracranial (EC-IC) cerebrovascular bypass. METHODS: After a curvilinear frontotemporal incision in 10 cadaveric specimens, the STA was dissected from distal to proximal...
October 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29106870/pediatric-tympanic-membrane-cholesteatoma-systematic-review-and-meta-analysis
#16
REVIEW
Harry H Ching, Alycia G Spinner, Matthew Ng
INTRODUCTION: Tympanic membrane cholesteatoma (TMC) is a rare anomaly found in pediatric patients with no significant otologic history. Its pathogenesis appears distinct from congenital mesotympanic cholesteatoma. This systematic review and meta-analysis evaluates the management of TMC. METHODS: Two authors independently conducted a systematic review using the PubMed-NCBI, Cochrane Library, and Web of Science databases. Studies describing cases of pediatric TMC were included...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29097036/-techniques-and-progress-in-the-imaging-of-the-ear
#17
Antoine Garin, Farida Benoudiba, Denis Ducreux
Ear and temporal bone imaging is essential for the diagnostic and preoperative management of middle ear lesions. The scanner is the exam of choice to analyze the walls and the contents of the middle ear. MRI is used to characterize the opacities of the middle ear and to evaluate possible neurological complications. Modern imaging techniques allow intraoperative guidance in otological surgery. Hearing implants are not always a contraindication to MRI but require precautions according to the type of implant.
October 30, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/29089158/cerebellar-ataxia-with-neuropathy-and-vestibular-areflexia-syndrome-canvas
#18
Masakatsu Taki, Takashi Nakamura, Hiraku Matsuura, Tatsuhisa Hasegawa, Hirofumi Sakaguchi, Kanako Morita, Ryotaro Ishii, Ikuko Mizuta, Takashi Kasai, Toshiki Mizuno, Shigeru Hirano
Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome (CANVAS) is a novel ataxic disorder consisting of the triad of cerebellar impairment, bilateral vestibular hypofunction, and a somatosensory deficit. We report the first Japanese case of CANVAS. The patient is a 68-year-old Japanese male. He was referred to our university for further evaluation of progressive gait disturbance and ataxia. He exhibited horizontal gaze-evoked nystagmus and sensory deficit. Nerve conduction studies showed sensory neuronopathy...
October 28, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29081427/clinical-and-video-head-impulse-test-in-the-diagnosis-of-posterior-circulation-stroke-presenting-as-acute-vestibular-syndrome-in%C3%A2-the-emergency-department
#19
Ayse Guler, Funda Karbek Akarca, Cenk Eraslan, Ceyda Tarhan, Cem Bilgen, Tayfun Kirazli, Nese Celebisoy
INTRODUCTION: Head impulse test (HIT) is the critical bedside examination which differentiates vestibular neuritis (VN) from posterior circulation stroke (PCS) in acute vestibular syndrome (AVS). Video-oculography based HIT (vHIT) may have aadditional strength in making the differentiation. METHODS: Patients admitted to the emergency department of a tertiary-care medical center with AVS were studied. An emergency specialist and a neurologist performed HIT. vHIT was conducted by an neuro-otology research fellow...
2017: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/29081317/evaluation-of-a-low-fidelity-ear-surgery-simulator-in-a-low-resource-setting
#20
K Luu, L Straatman, D Nakku, B Westerberg, N Carter, M Clark
OBJECTIVE: The provision of healthcare education in developing countries is a complex problem that simulation has the potential to help. This study aimed to evaluate the effectiveness of a low-cost ear surgery simulator, the Ear Trainer. METHODS: The Ear Trainer was assessed in two low-resource environments in Cambodia and Uganda. Participants were video-recorded performing four specific middle-ear procedures, and blindly scored using a validated measurement tool...
October 30, 2017: Journal of Laryngology and Otology
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