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Diabetes Complement

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https://www.readbyqxmd.com/read/29775936/from-hit-to-lead-structure-based-discovery-of-naphthalene-1-sulfonamide-derivatives-as-potent-and-selective-inhibitors-of-fatty-acid-binding-protein-4
#1
Ding-Ding Gao, Hui-Xia Dou, Hai-Xia Su, Ming-Ming Zhang, Ting Wang, Qiu-Feng Liu, Hai-Yan Cai, Hai-Peng Ding, Zhuo Yang, Wei-Liang Zhu, Ye-Chun Xu, He-Yao Wang, Ying-Xia Li
Fatty acid binding protein 4 (FABP4) plays a critical role in metabolism and inflammatory processes and therefore is a potential therapeutic target for immunometabolic diseases such as diabetes and atherosclerosis. Herein, we reported the identification of naphthalene-1-sulfonamide derivatives as novel, potent and selective FABP4 inhibitors by applying a structure-based design strategy. The binding affinities of compounds 16dk, 16do and 16du to FABP4, at the molecular level, are equivalent to or even better than that of BMS309403...
May 9, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29768089/a-commentary-on-effects-of-regular-physical-activity-on-the-cognitive-performance-of-type-2-diabetic-patients-a-systematic-review-by-podolski-et-al-metab-syndr-relat-disord-2017-15-481-493
#2
Erin M Shellington, Sonja M Reichert, Robert J Petrella
Type 2 diabetes mellitus (T2DM) imparts an increased risk for cognitive decline, specifically executive function, which is important to maintain for diabetes self-management. There is evidence to suggest that exercise improves cognition in healthy older adults; however, the literature in adults with T2DM is lacking. This commentary is in complement to Podolski et al.'s systematic review evaluating the effects of physical activity on cognitive function in adults with T2DM. We have included eight additional studies and further highlight their conclusions on the heterogeneity of the literature thus far...
May 16, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29757486/global-status-of-diabetes-prevention-and-prospects-for-action-a-consensus-statement
#3
REVIEW
Mahmoud Ibrahim, Jaakko Tuomilehto, Pablo Aschner, Lucille Beseler, Avivit Cahn, Robert H Eckel, Amy Hess Fischl, George Guthrie, James O Hill, Mick Kumwenda, R David Leslie, Darin E Olson, Paolo Pozzilli, Sandra L Weber, Guillermo E Umpierrez
Primary prevention of Type 2 Diabetes (T2D) should be achievable through the implementation of early and sustainable measures. Such prevention follows from addressing modifiable risk factors that predispose an individual to prediabetes, which then gradually progresses to T2D. Several randomised control studies that have found success in preventing the progression to T2D in high-risk populations1,2 have identified early and intensive intervention based on an individualised prevention model as the key factor for participant benefit...
May 14, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29742480/clinical-benefits-and-pharmacology-of-scutellarin-a-comprehensive-review
#4
REVIEW
Liping Wang, Qiang Ma
Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic tissue; but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury...
May 6, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29736760/assessment-of-bone-quality-in-patients-with-diabetes-mellitus
#5
REVIEW
N Jiang, W Xia
Substantial evidence exists that diabetes mellitus is associated with an increased risk of osteoporotic fractures. Low bone strength as well as bone extrinsic factors are probably contributing to the increased bone fragility in diabetes. Bone density and quality are important determinants of bone strength. Although bone mineral density (BMD) and the fracture risk assessment tool (FRAX) are very useful clinical tools in assessing bone strength, they may underestimate the fracture risk in diabetes mellitus. Through advances in new technologies such as trabecular bone score (TBS) and peripheral quantitative computed tomography (pQCT), we can better assess the bone quality and fracture risk of patients with diabetes mellitus...
May 7, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29729954/complement-activation-in-patients-with-diabetic-nephropathy
#6
X-Q Li, D-Y Chang, M Chen, M-H Zhao
AIM: Emerging evidence has indicated a role of the complement system in the pathogenesis of diabetic nephropathy (DN), although the pathways of complement activation and their clinicopathological relevance in DN are as yet unclear. The present study aimed to investigate levels of various complement components in plasma and urine of DN patients, and their correlation with clinicopathological parameters. METHODS: A total of 68 biopsy-proven DN patients with plasma samples were recruited, including 50 patients who also had urine samples available...
April 16, 2018: Diabetes & Metabolism
https://www.readbyqxmd.com/read/29725633/complement-activation-in-patients-with-diabetic-nephropathy
#7
Pascal Bus, Jamie S Chua, Céline Q F Klessens, Malu Zandbergen, Ron Wolterbeek, Cees van Kooten, Leendert A Trouw, Jan A Bruijn, Hans J Baelde
Introduction: Complement activation plays a role in various organs in patients with diabetes. However, in diabetic nephropathy (DN), the role of complement activation is poorly understood. We examined the prevalence and clinical significance of complement deposits in the renal tissue of cases with type 1 and type 2 diabetes with and without DN. Methods: We measured the prevalence of glomerular C4d, C1q, mannose-binding lectin (MBL), and C5b-9 deposits in 101 autopsied diabetic cases with DN, 59 autopsied diabetic cases without DN, and 41 autopsied cases without diabetes or kidney disease...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29703440/usefulness-of-complement-c1q-to-predict-10-year-mortality-in-men-with-diabetes-mellitus-referred-for-coronary-angiography
#8
Erdal Cavusoglu, John T Kassotis, Ayesha Anwar, Jonathan D Marmur, Syed Wasif Hussain, Sunitha Yanamadala, Sudhanva Hegde, Alexander Parpas, Calvin Eng, Ming Zhang
The complement system consists of a family of proteins that play a critical role in the innate immune system. Complement activation has been implicated in many chronic inflammatory diseases, including atherosclerosis. However, a number of experimental studies have highlighted a beneficial role of component C1q in early atherosclerosis and in diabetes mellitus (DM). Despite these data, there have been no studies that have specifically examined the utility of plasma complement C1q as a clinical biomarker in patients with known or suspected coronary artery disease...
March 28, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29701842/the-emerging-immunogenetic-architecture-of-schizophrenia
#9
Jennie G Pouget
Schizophrenia is a severe psychiatric disorder of complex etiology. Immune processes have long been proposed to contribute to the development of schizophrenia, and accumulating evidence supports immune involvement in at least a subset of cases. In recent years, large-scale genetic studies have provided new insights into the role of the immune system in this disease. Here, we provide an overview of the immunogenetic architecture of schizophrenia based on findings from genome-wide association studies (GWAS). First, we review individual immune loci identified in secondary analyses of GWAS, which implicate over 30 genes expressed in both immune and brain cells...
April 26, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29695256/metabolic-distress-in-lipid-one-carbon-metabolic-pathway-through-low-vitamin-b-12-a-population-based-study-from-north-india
#10
Kallur Nava Saraswathy, Shipra Joshi, Suniti Yadav, Priyanka Rani Garg
BACKGROUND: Dyslipidemia and hyper-homocysteinemia are the major independent risk factors of cardio vascular disease. Deficiency of folate and vitamin B-12 are associated with both hyper-homocysteinemia and dyslipidemia. The aim of the study is to evaluate the relationship of homocysteine and its associated dietary determinant levels (Folate and Vitamin B-12) with lipids and obesity parameters (WC, BMI, WHR) in North Indian population. METHODS: The participants were recruited under a major government funded project through household survey covering 15 villages of Haryana, India...
April 25, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29686159/cost-effectiveness-of-a-new-opportunistic-screening-strategy-for-walk-in-fingertip-hba-1c-testing-at-community-pharmacies-in-japan
#11
Aiko Shono, Masahide Kondo, Shu-Ling Hoshi, Reiko Okubo, Naoya Yahagi
OBJECTIVE: A new opportunistic community-based strategy was launched in Japan in April 2014 to detect lifestyle-related diseases, including diabetes, by creating Specimen Measurement Offices (SMOs). SMOs offer walk-in fingertip HbA1c testing. This article aimed to assess the value-for-money of HbA1c testing services at SMOs by conducting a cost-effectiveness analysis. RESEARCH DESIGN AND METHODS: We compared two scenarios: 1 ) status quo, defined as HbA1c testing that is available only through conventional screening; and 2 ) HbA1c testing available at SMOs as a complement to the status quo scenario...
April 23, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29681407/circulating-metabolites-of-strawberry-mediate-reductions-in-vascular-inflammation-and-endothelial-dysfunction-in-db-db-mice
#12
Chrissa Petersen, Divya Bharat, Brett Ronald Cutler, Samira Gholami, Christopher Denetso, Jennifer Ellen Mueller, Jae Min Cho, Ji-Seok Kim, J David Symons, Pon Velayutham Anandh Babu
BACKGROUND: Cardiovascular disease is 2-4-fold more prevalent in patients with diabetes. Human studies support the cardiovascular benefits of strawberry consumption but the effects of strawberry on diabetic vasculature are unknown. We tested the hypothesis that dietary strawberry supplementation attenuates vascular inflammation and dysfunction in diabetic mice. METHODS: Seven-week-old diabetic db/db mice that consumed standard diet (db/db) or diet supplemented with 2...
April 12, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29679800/synthetic-investigation-of-binary-ternary-cr-iii-hydroxycarboxylic-acid-aromatic-chelator-systems-structure-specific-influence-on-adipogenic-biomarkers-linked-to-insulin-mimesis
#13
O Tsave, C Gabriel, M Kafantari, M Yavropoulou, J G Yovos, C P Raptopoulou, V Psycharis, A Terzis, C Mateescu, A Salifoglou
In an attempt to understand the aqueous interactions of Cr(III) with low-molecular mass physiological ligands and examine its role as an adipogenic metallodrug agent in Diabetes mellitus II, the pH-specific synthesis in the binary-ternary Cr(III)-(HA = hydroxycarboxylic acid)-(N,N)-aromatic chelator (AC) (HA = 2-hydroxyethyl iminodiacetic acid/heidaH2 , quinic acid; AC = 1,10-phenanthroline/phen) systems was pursued, leading to four new crystalline compounds. All materials were characterized by elemental analysis, UV-Visible, FT-IR, and ESI-MS spectroscopy, cyclic voltammetry, and X-Ray crystallography...
February 10, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29679103/slc30a8-polymorphism-and-bmi-complement-hla-a-24-as-risk-factors-for-poor-graft-function-in-islet-allograft-recipients
#14
Else M Balke, Simke Demeester, DaHae Lee, Pieter Gillard, Robert Hilbrands, Ursule Van de Velde, Bart J Van der Auwera, Zhidong Ling, Bart O Roep, Daniël G Pipeleers, Bart Keymeulen, Frans K Gorus
AIMS/HYPOTHESIS: HLA-A*24 carriership hampers achievement of insulin independence in islet allograft recipients. However, less than half of those who fail to achieve insulin independence carry the allele. We investigated whether genetic polymorphism at the recipients' zinc transporter 8-encoding SLC30A8 gene (rs13266634) could complement their HLA-A*24 status in predicting functional graft outcome. METHODS: We retrospectively analysed data of a hospital-based patient cohort followed for 18 months post transplantation...
April 20, 2018: Diabetologia
https://www.readbyqxmd.com/read/29656956/ultrasound-assessed-visceral-fat-and-associations-with-glucose-homeostasis-and-cardiovascular-risk-in-clinical-practice
#15
M Bellan, M Menegatti, C Ferrari, G P Carnevale Schianca, M Pirisi
BACKGROUND AND AIMS: Despite the lack of evidence that assessing the global cardiovascular risk leads to a decreased incidence of cardiovascular events, accurate patient profiling is paramount in preventive medicine. An excess of visceral fat (VF) is associated with an enhanced cardiovascular risk; importantly, VF is quantifiable rapidly, cheaply and safely by ultrasound, which makes it suitable for use in clinical practice. In the present study, we aimed to evaluate if US-measured VF (USVF) could be a better predictor of glucose homeostasis and cardiovascular risk than simple anthropometric measures...
February 2, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29628329/structure-guided-evolution-of-a-2-phenyl-4-carboxyquinoline-chemotype-into-ppar%C3%AE-selective-agonists-new-leads-for-oculovascular-conditions
#16
Xiao-Zheng Dou, Dinesh Nath, Younghwa Shin, Jian-Xing Ma, Adam S Duerfeldt
Small molecule agonism of PPARα represents a promising new avenue for the development of non-invasive treatments for oculovascular diseases like diabetic retinopathy and age-related macular degeneration. Herein we report initial structure-activity relationships for the newly identified quinoline-based PPARα agonist, Y-0452. Preliminary computational studies led to the hypothesis that carboxylic acid transposition and deconstruction of the Y-0452 quinoline system would enhance ligand-protein interactions and better complement the nature of the binding pocket...
April 5, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29627887/clinical-application-of-multicolour-scanning-laser-imaging-in-diabetic-retinopathy
#17
Shuting Li, Xiangning Wang, Xinhua Du, Qiang Wu
To compare the visualization of the lesions of diabetic retinopathy (DR) using multicolour scanning laser imaging (MSLI) and conventional colour fundus photography (CFP). The paired images of diabetic patients who underwent same-day MSLI and CFP examinations were reviewed. Combined multicolour (MC) images were acquired simultaneously using three laser wavelengths: blue reflectance (BR, λ = 488 nm), green reflectance (GR, λ = 518 nm) and infrared reflectance (IR, λ = 820 nm). The number of positive DR lesions was calculated using fundus fluorescein angiography as the reference standard...
April 7, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29625935/antihyperglycemic-effect-of-conocarpus-erectus-leaf-extract-in-alloxan-induced-diabetic-mice
#18
Syed Ali Raza, Ayoub Rashid Chaudhary, Muhammad Waseem Mumtaz, Abdul Ghaffar, Ahmad Adnan, Abdul Waheed
Synthetic drugs have widely been helpful in management of diabetes mellitus type 2. However, side effects associated with synthetic drugs serve as an impetus to explore plants as alternate mode of treatment. The hydroethanolic leaf extracts of Conocarpus erectus were evaluated for phenolic contents, flavonoid distribution, antioxidant activity and antidiabetic potential. The maximum extract yield, total phenolic and flavonoid contents were exposed by 60% ethanolic extract. The Antioxidant and anti α-glucosidase tendency of 60% ethanolic extract was the most promising and complemented by in-vivo antihyperglycemic impact on mice...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29617393/cost-and-economic-burden-of-illness-over-15-years-in-nepal-a-comparative-analysis
#19
Khin Thet Swe, Md Mizanur Rahman, Md Shafiur Rahman, Eiko Saito, Sarah K Abe, Stuart Gilmour, Kenji Shibuya
BACKGROUND: With an increasing burden of non-communicable disease in Nepal and limited progress towards universal health coverage, country- and disease-specific estimates of financial hardship related to healthcare costs need to be evaluated to protect the population effectively from healthcare-related financial burden. OBJECTIVES: To estimate the cost and economic burden of illness and to assess the inequality in the financial burden due to catastrophic health expenditure from 1995 to 2010 in Nepal...
2018: PloS One
https://www.readbyqxmd.com/read/29604259/lectin-induced-renal-local-complement-activation-is-involved-in-tubular-interstitial-injury-in-diabetic-nephropathy
#20
Jing-Min Zheng, Xian-Guo Ren, Zuan-Hong Jiang, De-Jun Chen, Wen-Jin Zhao, Li-Juan Li
BACKGROUND: Complement has been suggested to be involved in diabetic nephropathy (DN), but the exact significance and underlying mechanisms remain unclear. Data about renal local complement activation in DN patients is scarce. The purpose of the study was to clarify the significance and mechanism of renal local complement activation in DN. METHODS: Sixty-two biopsy-proven DN patients were recruited. Renal expression of C1Q, factor B, C5b-9, MBL and MBL-associated serine protease 1 (MASP1) were detected and associated with the kidney damage...
March 28, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
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