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M E Tabernero, F Musich, F C Cossini, D G Politis
AIM: To study the presence of alterations in social cognition in Parkinson's disease dementia (PDD) and behavioral variant frontotemporal dementia (bvFTD), to compare the levels of involvement, and to analyze their relevance as a tool to distinguish between both demential profile. SUBJECTS AND METHODS: For this purpose, 34 patients diagnosed with PDD, 21 men and 13 women, with an average age of 70 years and 8 years of education, and 26 patients diagnosed with bvFTD, 9 men and 17 women, with an average age of 68 years and 6 years of education, were assessed...
December 16, 2017: Revista de Neurologia
Fabiano Moulin de Moraes, Paulo Henrique Ferreira Bertolucci
BACKGROUND: Assigning a diagnosis to a patient with dementia is important for the present treatment of the patient and caregivers, and scientific research. Nowadays, the dementia diagnostic criteria are based on clinical information regarding medical, history, physical examination, neuropsychological tests, and supplementary exams and, therefore, subject to variability through time. METHODS: A retrospective observational study to evaluate variables related to clinical diagnostic stability in dementia syndromes in at least one year follow up...
June 15, 2017: International Psychogeriatrics
Iwona Bojar, Mariusz Gujski, Jarosław Pinkas, Dorota Raczkiewicz, Alfred Owoc, Ewa Humeniuk
INTRODUCTION: A potential factor increasing the risk of the development of cognitive impairment with age is apolipoprotein E (APOE) ε4 carrier status. A subsequent factor which may increase the risk of development of cognitive impairment at an older age is the concentration of C-reactive protein (CRP). The objective of the study was to examine the relationship between cognitive functions and the concentration of CRP in post-menopausal women who were carriers of particular apolipoprotein E gene (APOE) polymorphisms...
December 1, 2016: Archives of Medical Science: AMS
Roksana Ewa Zofia Malak, Agnieszka Krawczyk-Wasielewska, Katarzyna Głodowska, Bartosz Grobelny, Paweł Kleka, Ewa Mojs, Przemysław Keczmer, Włodzimierz Samborski
INTRODUCTION: Caregivers of demented relatives devote their time and attention in order to help the beloved members of the family. Those who are informal caregivers require support in order to avoid being overburdened. Many such caregivers may suffer from chronic health problems, for instance, depression. OBJECTIVE: The aim was to assess the factors of depression in caregivers, and to discover the determinants of depression among informal family caregivers of demented individuals...
September 2016: Annals of Agricultural and Environmental Medicine: AAEM
Kristina M Kokorelias, Ellen B Ryan, Gail Elliot
Regression to mother tongue is common in those with dementia. In two long-term care facilities, we explored the use of bilinguals' two languages for five older adults with mild-moderate dementia who have begun to regress to Greek. We also examined the role of Montessori DementiAbility Methods: The Montessori Way-based English language activities in fostering conversational use of English. Over 10 sessions, participants' vocabulary or grammatical structure in English did not improve. However, four of the five participants were able to maintain a conversation in English for longer periods of time...
February 2017: Dementia
C A Magalhães, M G Carvalho, L P Sousa, P Caramelli, K B Gomes
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly population. AD is histologically characterized by accumulation of amyloid-β protein (Aβ) on extracellular plaques and deposition of hyperphosphorylated tau protein in intracellular neurofibrillary tangles. Several studies have shown that obesity may precede dementia and that lifestyle factors play a critical role in the onset of AD. Furthermore, accumulating evidence indicates that obesity is an independent risk factor for developing AD...
October 23, 2015: Clinica Chimica Acta; International Journal of Clinical Chemistry
Michelle S Bourgeois, Jennifer Brush, Gail Elliot, Anne Kelly
Efforts to improve the quality of life of persons with dementia in long-term care through the implementation of various approaches to person-centered care have been underway for the past two decades. Studies have yielded conflicting reports evaluating the evidence for these approaches. The purpose of this article is to outline the findings of several systematic reviews of this literature, highlighting the areas of improvement needs, and to describe a new person-centered care model, DementiAbility Methods: The Montessori Way...
August 2015: Seminars in Speech and Language
Marcel G M Olde Rikkert, Eric van Exel, Wilma Knol, A W Evelien Lemstra, Gerwin Roks, Frans R J Verhey
- The Dutch dementia guideline has been extended to include recommendations in the area of psychosocial interventions for patients, caregivers and professionals.- The diagnostic recommendations in the revised directive are based on a stepwise work-up with the aim of establishing the cause of the dementia. This is guided by the recent diagnostic criteria, evidence of the diagnostic value of additional investigations, and the patient's wishes.- Although there have been no major breakthroughs in the treatment of patients with Alzheimer's disease in recent years, the revised guideline also contains important new recommendations in this area...
2015: Nederlands Tijdschrift Voor Geneeskunde
Florence Rémy, Nathalie Vayssière, Laure Saint-Aubert, Emmanuel Barbeau, Jérémie Pariente
White matter tract alterations have been consistently described in Alzheimer's disease (AD). In particular, limbic fronto-temporal connections, which are critical to episodic memory function, may degenerate early in the course of the disease. However the relation between white matter tract degeneration, hippocampal atrophy and episodic memory impairment at the earliest stages of AD is still unclear. In this magnetic resonance imaging study, white matter integrity and hippocampal volumes were evaluated in patients with amnestic mild cognitive impairment due to AD (Albert et al...
2015: NeuroImage: Clinical
Rostam Seifaddini, Haleh Tajadini, Rasool Choopani
The most common cognitive disorder that is disabling is dementia. During the medieval period, traditional Persian medicine was an outstanding source of medicine that was used as standard references in medical schools of in the West and Middle East. In ancient manuscripts of traditional Persian medicine, a condition has been introduced similar to dementi (raoonat and homgh). In this article, by collecting materials of traditional medicine texts on dementia, we aim to provide theories for further studies on this topics, as there is an obvious difference between traditional Persian medicine and modern medicine with regard to dementia; however, since modern medicine has not found a suitable response to treatment for all diseases, reviewing traditional Persian medicine for finding better treatment strategies is wise...
July 2015: Journal of Evidence-based Complementary & Alternative Medicine
L A R Zwart, M Goudsmit, J P C M van Campen, C J M Rijkers, A W Wind
The Dutch population of first generation Turkish and Moroccan migrants is ageing. Among them hypertension and diabetes mellitus are frequent findings, which will probably cause an increased incidence of dementia. The language barrier, low education and cultural differences make the diagnosis more difficult. To what extent the MMSE can be used as a cognitive screener in this population will be investigated in this retrospective study.Patients received standard diagnostics, a professional translator addressed the language barrier...
February 2015: Tijdschrift Voor Gerontologie en Geriatrie
Han Diesfeldt
No abstract text is available yet for this article.
September 2014: Tijdschrift Voor Gerontologie en Geriatrie
Ashok K Jainer, Demi Onalaja, Fabida Noushad
We report an interesting case study of a 58-year-old woman who had early onsct dementis which initially presented with marked features of anxiety that masked her cognitive impairment. She was treated for anxiety for about 2 years. Her anxiety symptoms caused hindrance in detecting dementis at the early stage.
2005: International Journal of Psychiatry in Clinical Practice
Laure Saint-Aubert, Emmanuel J Barbeau, Patrice Péran, Federico Nemmi, Celine Vervueren, Helene Mirabel, Pierre Payoux, Anne Hitzel, Fabrice Bonneville, Raluca Gramada, Mathieu Tafani, Christian Vincent, Michele Puel, Sophie Dechaumont, Francois Chollet, Jeremie Pariente
BACKGROUND: Florbetapir (AV-45) has been shown to be a reliable tool to assess amyloid load in patients with Alzheimer's disease (AD) at demential stages. Longitudinal studies also suggest that AV-45 has the ability to bind amyloid in the early stages of AD. In this study, we investigated AV-45 binding and its relation with cognitive performance in a group of patients at the prodromal stage of Alzheimer's disease, recruited according to strict inclusion criteria. METHODS: We recruited patients at the prodromal stage of AD and matched control subjects...
2013: EJNMMI Research
Achim Rose, Anne Thimme, Carolin Halfar, Hans Georg Nehen, Herbert Rübben
INTRODUCTION: The prevalence of urinary incontinence increases with age. Especially in nursing homes people often do not only suffer from incontinence, in addition they present comorbidities, i.e. dementia or loss of mobility. In this study we assessed the severity of urinary incontinence and comorbidities of nursing home residents. METHODS: We included 81 residents of nursing homes who underwent recordings of medical history, physical examination and ultrasound diagnostic of the urinary tract...
2013: Urologia Internationalis
Sverre Bergh, Jostein Holmen, Ingvild Saltvedt, Kristian Tambs, Geir Selbæk
Background: Earlier studies have revealed a high prevalence of dementia among nursing home patients. We conducted a descriptive study of dementia and neuropsychiatric symptoms among patients in nursing homes in Nord-Trøndelag County, Norway. Material and methods: 704 nursing home patients were included and studied with the Norwegian versions of the clinical demential rating scale (CDR) and the neuropsychiatric inventory (NPI). Results: The study indicated that 575 patients (82%) had dementia. Of these, 430 patients (75%) had at least one clinically significant neuropsychiatric syndrome in addition, most commonly delusions, apathy or irritability...
September 18, 2012: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Niels Hansen
The pharmacological treatment of Alzheimer's disease (AD) is often limited and accompanied by drug side effects. Thus alternative therapeutic strategies such as non-invasive brain stimulation are needed. Few studies have demonstrated that transcranial direct current stimulation (tDCS), a method of neuromodulation with consecutive robust excitability changes within the stimulated cortex area, is beneficial in AD. There is also evidence that tDCS enhances memory function in cognitive rehabilitation in depressive patients, Parkinson's disease, and stroke...
2012: Frontiers in Psychiatry
Guilherme Lepski, Cinthia E Jannes, Johanna Wessolleck, Eiji Kobayashi, Guido Nikkhah
INTRODUCTION: The hippocampal formation is a specific structure in the brain where neurogenesis occurs throughout adulthood and in which the neuronal cell loss causes various demential states. The main goal of this study was to verify whether fetal neural progenitor cells (NPCs) from transgenic rats expressing green fluorescent protein (GFP) retain the ability to differentiate into neuronal cells and to integrate into the hippocampal circuitry after transplantation. METHODS: NPCs were isolated from E14 (gestational age: 14 days postconception) transgenic-Lewis and wild-type Sprague-Dawley rat embryos...
February 27, 2011: Transplantation
Simone Garruth Sampaio, Roberto A Lourenço
INTRODUCTION: The Cambridge Examination for Mental Disorders of the Elderly - revised (CAMDEX-R) is an instrument developed in England and used as an aid to the diagnosis of dementia, mainly in its initial forms. It contains nine sections (named from A to I), including a neuropsychological evaluation and an interview with an informant (section H). This kind of interview has proved to be useful in the detection of dementia. OBJECTIVE: To translate and transculturally adapt to Brazilian Portuguese the section H of CAMDEX-R...
September 2009: Acta Médica Portuguesa
Daoquan Tang, Zunjian Zhang, Yuanyuan Gao, Yaqin Wei, Lin Han
ETHNOPHARMACOLOGICAL RELEVANCE: Ginkgo biloba extract (GBE) is an ancient Chinese phytomedicine which was used to treat various ailments including circulatory and demential disorders. AIM OF THE STUDY: To study GBE's protective effects on the glomerulosclerosis of diabetic nephropathy (DN) in rat mesangial cells by serum pharmacological methods. MATERIALS AND METHODS: The cultured mesangial cells were divided into seven groups: normal, solvent control, high glucose, low dose of GBE serum, moderate dose of GBE serum, high dose of GBE serum, and GBE...
July 6, 2009: Journal of Ethnopharmacology
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