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https://www.readbyqxmd.com/read/28212540/expression-of-met-in-circulating-tumor-cells-correlates-with-expression-in-tumor-tissue-from-advanced-stage-lung-cancer-patients
#1
Marius Ilie, Edith Szafer-Glusman, Véronique Hofman, Elodie Long-Mira, Rebecca Suttmann, Walter Darbonne, Catherine Butori, Salomé Lalvée, Julien Fayada, Eric Selva, Wei Yu, Charles-Hugo Marquette, David S Shames, Elizabeth Punnoose, Paul Hofman
Given the difficulty in obtaining adequate tissue in NSCLC, we investigated the utility of circulating tumor cells (CTCs) for MET status assessment in NSCLC patients. We used two platforms for CTC capture, and assessed MET expression in CTCs and matched-bronchial biopsies in patients with advanced-stage III/IV lung adenocarcinoma. Baseline peripheral blood was collected from 256 advanced-stage III/IV NSCLC patients from Genentech clinical trials, and from 106 patients with advanced-stage III/IV lung adenocarcinoma treated at the Department of Pneumology, Pasteur Hospital, Nice...
February 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28152018/acute-kidney-injury-burden-in-different-clinical-units-data-from-nationwide-survey-in-china
#2
Xiaojing Tang, Dongping Chen, Shengqiang Yu, Li Yang, Changlin Mei
BACKGROUND: The inpatient morbidity and mortality of acute kidney injury (AKI) vary considerably in different clinical units, yet studies to compare the difference remain limited. METHODS: We compared the clinical characteristics of AKI in Intensive Care Unit (ICU), medical and surgical departments by using the data derived from the 2013 nationwide cross-sectional survey of AKI in China to capture variations among different clinical departments in recognition, management, and outcomes of AKI...
2017: PloS One
https://www.readbyqxmd.com/read/28120698/short-course-daptomycin-lock-and-systemic-therapy-for-catheter-related-bloodstream-infections-a-retrospective-cohort-study-in-cancer-patients-with-surgically-implanted-devices
#3
Matteo Vassallo, Pierre-Luc Genillier, Brigitte Dunais, Regis Kaphan, Laurence Saudes, Yannick Duval, Fabien Rolland, Valerie Jullien, Nicolas Weiss, Elea Blanchouin, Annick Boscagli, Christophe Perrin, Nathalie Montagne
PURPOSE: Few in vivo studies have been reported describing efficacy and duration of antibiotic lock therapy (ALT) with daptomycin (DPT) for long-term catheter-related bloodstream infections (CRBSI) due to coagulase-negative staphylococci (CoNS). We retrospectively analysed the efficacy of short-course ALT with DPT in combination with systemic treatment (ST) for CoNS-associated CRBSI in our hospital. METHODS: Patients admitted for CoNS-associated CRBSI and treated with DPT as ALT and ST were retrospectively analysed...
January 25, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28114706/-lung-health-data-of-the-study-of-health-in-pomerania-a-review-of-samples-methods-and-first-results
#4
R Ewert, T Ittermann, T Bollmann, T Spielhagen, M Dörr, C Schäper, C Warnke, A Obst, N Friedrich, S B Felix, M R P Markus, M Piontek, T Penzel, I Fietze, M Glos, B Stubbe, S Desole, S Kaczmarek, C O Schmidt, H Völzke, S Gläser
Investigating reasons for differing life expectancy and prevalence of cardiovascular risk factors between old and new states of the Federal Republic of Germany an epidemiological study in Western Pomerania - the population-based project Study of Health in Pomerania (SHIP) - was planned.Prevalence and incidence of common risk factors, subclinical disorders and clinical diseases have been assessed since 1997 in five-year intervals. The third follow up (SHIP-3) was assessed between 2014 and 2016. In addition, an independent representative population sample was investigated between 2008 - 2012 (SHIP-TREND)...
January 2017: Pneumologie
https://www.readbyqxmd.com/read/28051229/contribution-of-fixed-dose-combinations-in-the-treatment-of-tuberculosis
#5
Sonia Toujani, Boutheina Ben Safta, Nozha Ben Salah, Meriem Mjid, Yacine Ouahchi, Béchir Louzir, Jalloul Daghfous, Jouda Cherif, Nadia Mehiri, Majed Beji
Background - The introduction of fixed-dose combinations (FDCs) of TB treatment in Tunisia is recent (July 2009). WHO and the National Tuberculosis Programme recommend the use of fixed-dose combination (FDC) tablets for the treatment of tuberculosis (TB). The effectiveness of ADF has been demonstrated, however the risk of relapse and tolerance were controversial. Objective - Through a retrospective study, we evaluate, the contribution of FDCs compared with dissociated treatment (TD) (efficacy, tolerance and the occurrence of relapses)...
July 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28028697/quality-of-life-in-adults-with-asthma-treated-in-allergy-and-pneumology-subspecialties-relationship-with-sociodemographic-clinical-and-psychological-variables
#6
Beatriz González-Freire, Isabel Vázquez
PURPOSE: Prior studies suggest that specialist care associates with improved health-related quality of life (HRQL) in asthmatic patients. However, there are limited studies focused on differences in HRQL among subspecialties. The aim of this study was to assess the differences in HRQL between adult asthmatic patients treated in pneumology or allergy practices, and to estimate to what extent the differences in HRQL can be explained by sociodemographic, clinical or psychological characteristics of patients from each specialty...
December 27, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27999149/time-required-to-rectify-inhaler-errors-among-experienced-subjects-with-a-faulty-technique
#7
Andrea S Melani, Marco Bonavia, Eliuccia Mastropasqua, Alessandro Zanforlin, Marco Lodi, Paola Martucci, Nicola Scichilone, Maria Aliani, Margherita Neri, Piersante Sestini
BACKGROUND: Regardless of the device used, many patients have difficulty maintaining proper inhaler technique over time. Repeated education from caregivers is required to ensure persistence of correct inhaler technique, but no information is available to evaluate the time required to rectify inhaler errors in experienced users with a baseline faulty technique and whether this time of re-education to restore inhaler mastery can differ between devices. METHODS: This was a multi-center, single-visit, open-label, cross-sectional study in a large group of 981 experienced adult subjects (mean ± SD age 64 ± 15 y), mainly suffering from COPD and asthma, who showed faulty inhaler technique at a follow-up visit in chest clinics...
December 20, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27918254/clinical-implications-of-mycobacterium-chimaera-detection-in-thermoregulatory-devices-used-for-extracorporeal-membrane-oxygenation-ecmo-germany-2015-to-2016
#8
Franziska C Trudzinski, Uwe Schlotthauer, Annegret Kamp, Kai Hennemann, Ralf M Muellenbach, Udo Reischl, Barbara Gärtner, Heinrike Wilkens, Robert Bals, Mathias Herrmann, Philipp M Lepper, Sören L Becker
Mycobacterium chimaera, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and M. chimaera might also be detectable in ECMO treatment settings...
November 17, 2016: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/27822177/smoking-cessation-attempts-is-it-useful-to-treat-hard-core-smokers
#9
B Joly, P D'Athis, L Gerbaud, J Hazart, J Perriot, C Quantin
BACKGROUND: Hard core smokers have been studied in many countries but only a few trials have compared the effectiveness of smoking cessation with other smokers. The objective of this study was to compare the frequencies of success in smoking cessation between hard-core smokers and other smokers. METHODS: Data were collected in Clermont-Ferrand from the Emile Roux dispensary 'Pneumology and Tobaccology Centre' between 1999 and 2009. Assistance with smoking cessation was proposed to 1367 patients but only 1296 patients were included: 219 HCS and 1077 other smokers...
2016: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/27816309/-the-seasonal-flu-vaccination-among-caregivers-in-geriatric-units-up-to-date
#10
E Contal, A Putot, M Dipanda, S Perrin, S Asgassou, H Sordet-Guépet, P Manckoundia
BACKGROUND: Flu vaccinations for healthcare professionals seems to be one of the most effective preventive actions in the face of a disease that carries a high risk of a potentially serious nosocomial epidemic in a geriatric environment. The aim of this study was to take stock of the flu vaccination status among caregivers in the geriatric units and to understand the reasons for their reluctance to be vaccinated, in order to put forward proposals to improve vaccination coverage. METHOD: A literature search of articles published since 2000 in the area of geriatrics, infectious diseases or pneumology was mainly conducted on PubMed using the keywords "caregivers", "elderly", "flu", "influenza", "nosocomial" and "vaccination"...
December 2016: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/27749546/high-prevalence-of-known-and-unknown-pulmonary-diseases-in-patients-with-claudication-during-exercise-oximetry-a-retrospective-analysis
#11
Christophe Colas-Ribas, Isabelle Signolet, Samir Henni, Mathieu Feuillloy, Frédéric Gagnadoux, Pierre Abraham
The prevalence of pulmonary disease in patients with peripheral artery disease (PAD) has not been extensively studied. Recent evidence has shown that ∼20% of the patients have an atypical chest transcutaneous oxygen pressure (TcpO2) pattern during exercise, which suggests walking-induced hypoxemia. The main objectives of this study were to: (1) describe in a retrospective way the characteristics of the patients suffering from claudication, who attended a treadmill testing in our laboratory, (2) assess the prevalence of known or unknown pulmonary disease...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27641763/-contribution-of-fiberoptic-bronchoscopy-in-the-diagnosis-of-pulmonary-dragging
#12
K Thiam, E H M Ndiaye, N O Touré, Y Dia Kane, F B R Mbaye, M F Cissé
INTRODUCTION: Bronchoscopy is recommended into the exploration of chronic lung diseases. This one is expensive and invasive. We conducted this study in order to assess the benefit of the bronchoscopy in the etiologic diagnosis of chronic lung diseases. PATIENTS AND METHODS: This study was retrospective, descriptive and analytical, using medical records of outpatients and in patients who has done the bronchoscopy in Pneumology Clinic, Fann hospital, Dakar from January 2010 to December 2014...
October 2016: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/27640221/the-development-of-pain-medicine-in-italy-and-the-rest-of-europe-40-years-after-the-first-international-association-for-the-study-of-pain-congress
#13
Giustino Varrassi, Antonella Paladini
Professor Giustino Varrassi and Antonella Paladini speak to Jade Parker, Commissioning Editor: Professor Giustino Varrassi is Full Professor of Anesthesiology and Pain Medicine in the LUdeS University, Valletta, Malta. He graduated at the Medical School of the University 'La Sapienza' (Rome, Italy) in 1973, and became board certified in Anesthesiology and Intensive Care in 1976 and in Pneumology in 1978, both in the same Medical School. He is currently President of the European League Against Pain and of the Paolo Procacci Foundation, and is a founding member of both of these...
January 2017: Pain Management
https://www.readbyqxmd.com/read/27590300/confidentiality-breaches-in-clinical-practice-what-happens-in-hospitals
#14
Cristina M Beltran-Aroca, Eloy Girela-Lopez, Eliseo Collazo-Chao, Manuel Montero-Pérez-Barquero, Maria C Muñoz-Villanueva
BACKGROUND: Respect for confidentiality is important to safeguard the well-being of patients and ensure the confidence of society in the doctor-patient relationship. The aim of our study is to examine real situations in which there has been a breach of confidentiality, by means of direct observation in clinical practice. METHODS: By means of direct observation, our study examines real situations in which there has been a breach of confidentiality in a tertiary hospital...
2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27543792/management-and-referral-of-patients-with-severe-and-poorly-controlled-asthma-in-primary-care
#15
Domingo Orozco-Beltrán, Concepción Carratalá-Munuera, Juan M Arriero, Paloma Campo, Eva Martínez-Moragón, Jesús Molina, José Antonio Quintano-Jiménez, Vicente F Gil-Guillén
BACKGROUND: Over 50% of treated patients with asthma in Europe are not well controlled. Their management in primary health care (PHC) differs from that in specialized care, and there is no real coordination between the two. OBJECTIVES: To identify barriers and solutions to improving the management of patients with severe and poorly controlled asthma and the communication between specialists and PHC, and to reach a consensus on the criteria for referral patients...
December 2016: Family Practice
https://www.readbyqxmd.com/read/27494830/new-therapeutic-strategies-for-invasive-aspergillosis-in-the-era-of-azole-resistance-how-should-the-prevalence-of-azole-resistance-be-defined
#16
Alexandre Alanio, Blandine Denis, Samia Hamane, Emmanuel Raffoux, Régis Peffault de la Tour, Sophie Touratier, Anne Bergeron, Stéphane Bretagne
Given reports showing a high prevalence of azole resistance in Aspergillus fumigatus, alternatives to azole therapy are discussed when a threshold of 10% of azole-resistant environmental isolates is reached. This raises the issue of calculation of this threshold, either on the prevalence of azole-resistant isolates as a whole or on the prevalence of azole-resistant cases in populations at risk of invasive aspergillosis (IA). For isolate evaluation, there are high disparities in routine microbiological procedures for the isolation of A...
August 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27490813/identification-of-antigenic-proteins-from-lichtheimia-corymbifera-for-farmer-s-lung-disease-diagnosis
#17
Bénédicte Rognon, Coralie Barrera, Michel Monod, Benoit Valot, Sandrine Roussel, Manfredo Quadroni, Stephane Jouneau, Isabelle Court-Fortune, Denis Caillaud, Jean-Marc Fellrath, Jean-Charles Dalphin, Gabriel Reboux, Laurence Millon
The use of recombinant antigens has been shown to improve both the sensitivity and the standardization of the serological diagnosis of Farmer's lung disease (FLD). The aim of this study was to complete the panel of recombinant antigens available for FLD serodiagnosis with antigens of Lichtheimia corymbifera, known to be involved in FLD. L. corymbifera proteins were thus separated by 2D electrophoresis and subjected to western blotting with sera from 7 patients with FLD and 9 healthy exposed controls (HEC). FLD-associated immunoreactive proteins were identified by mass spectrometry based on a protein database specifically created for this study and subsequently produced as recombinant antigens...
2016: PloS One
https://www.readbyqxmd.com/read/27487699/-history-of-pneumology-in-antiquity-part-2
#18
Ph Demaeyer
Nowadays, Hippocrate, "The Father of Medicine", still influences our medicine. He was famous because of the great medical corpus texts preserved in his name. Only recently, our universities have updated the famous Hippocratic Oath to avoid contradictions with our modern ethics. Hippocrate was a great clinician but a poor anatomist. Hippocratical humourism remained accurate until the age of the enlightenment (18th century). Furthermore, it is difficult to distinguish medicine from philosophy in Greek antiquity...
March 2016: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/27419673/-factors-affecting-the-quality-of-cardiopulmonary-resuscitation-in-inpatient-units-perception-of-nurses
#19
Clairton Marcos Filho Citolino, Eduesley Santana Santos, Rita de Cassia Gengo E Silva, Lilia de Souza Nogueira
OBJECTIVE: To identify, in the perception of nurses, the factors that affect the quality of cardiopulmonary resuscitation (CPR) in adult inpatient units, and investigate the influence of both work shifts and professional experience length of time in the perception of these factors. METHOD: A descriptive, exploratory study conducted at a hospital specialized in cardiology and pneumology with the application of a questionnaire to 49 nurses working in inpatient units...
December 2015: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/27419396/adherence-to-long-acting-bronchodilators-after-discharge-for-copd-how-much-of-the-geographic-variation-is-attributable-to-the-hospital-of-discharge-and-how-much-to-the-primary-care-providers
#20
Mirko Di Martino, Martina Ventura, Giovanna Cappai, Adele Lallo, Marina Davoli, Nera Agabiti, Danilo Fusco
In moderate-severe chronic obstructive pulmonary disease (COPD), long-acting bronchodilators (LBs) are recommended to improve the quality of life. The aims of this study were to measure adherence to LBs after discharge for COPD, identify determinants of adherence, and compare amounts of variation attributable to hospitals of discharge and primary care providers, i.e. local health districts (LHDs) and general practitioners (GPs). This cohort study was based on the Lazio region population, Italy. Patients discharged in 2007-2011 for COPD were followed up for 2 years...
February 2017: COPD
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