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https://www.readbyqxmd.com/read/29236360/low-risk-of-avian-influenza-a-h5n6-transmission-to-depopulation-workers-in-korea
#1
Sukhyun Ryu, Jun-Sik Lim, Benjamin J Cowling, Byung Chul Chun
An outbreak of highly pathogenic avian influenza A (H5N6) virus occurred between November 20, 2016 and March 1, 2017 in poultry farms, in the Gyeonggi Province, Republic of Korea. To identify the risk of transmission of H5N6 to depopulation workers, active and passive surveillance was conducted. Virological testing of respiratory swabs with real-time reverse transcription-polymerase chain reaction was performed for workers who reported respiratory symptoms. Among 4633 depopulation workers, 25 reported respiratory symptoms, but all tested negative for H5N6...
December 13, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29236328/mirnalet-7a-mediates-prostate-cancer-pc-3-cell-invasion-migration-by-inducing-epithelial-mesenchymal-transition-through-ccr7-mapk-pathway
#2
Tang Guanlin, Du Ruoyang, Tang Zhaobing, Kuang Youlin
Prostate cancer is one of the most common malignancies in older men. Recent evidence has demonstrated microRNA (miRNA) Let-7a expression decreased in prostate cancer, while the expression of C-C chemokine receptor type 7 (CCR7) increased. In this study, we investigated whether CCR7 overexpression was associated with a decrease in the expression of miRNA let-7a in invasion and metastasis of prostate cancer cell. Methods Synthetic let-7a mimics and let-7a inhibitors were transfected into prostate cancer PC-3 cells repectively...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236323/effects-of-microrna-330-on-vulnerable-atherosclerotic-plaques-formation-and-vascular-endothelial-cell-proliferation-through-the-wnt-signaling-pathway-in-acute-coronary-syndrome
#3
Jing Ren, Rui Ma, Zhu-Bo Zhang, Yang Li, Ping Lei, Jian-Long Men
This study is designed to investigate the effects of microRNA (miR)-330 on atherosclerotic plaques formation and vascular endothelial (VE) cell proliferation by targeting MAPK8 through the WNT signaling pathway in rats with acute coronary syndrome (ACS). Expression of hemodynamic variables were tested. Rats were allocated into control, blank, negative control (NC), miR-330 mimic, miR-330 inhibitor, DDK-1, miR-330 inhibitor + DDK-1 groups. ELISA was used to evaluate the expression of TC, TG, LDL-C, hs-CRP, IL-6, IL-10, TNF-α, and SAA...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236292/a-novel-report-of-mir-4301-induces-cell-apoptosis-by-negatively-regulating-drd2-expression-in-human-breast-cancer-cells
#4
Naghmeh Gholipour, Anna Ohradanova-Repic, Ghasem Ahangari
BACKGROUND: In several cancers, microRNA (miRNAs) play vital roles in tumour initiation, drug resistance and metastasis. The aim of this study was to examine the expression levels of miR-4301 in human breast cancer and investigate whether its potential roles involved targeting Dopamine receptor D2 (DRD2). METHODS: Real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) was also used to examine the expression levels of miR-4301 in human breast cancer cell lines MDA-MB-231, MCF-7 and SKBR3...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236289/assessment-of-cellular-and-serum-proteome-from-tongue-squamous-cell-carcinoma-patient-lacking-addictive-proclivities-for-tobacco-betel-nut-and-alcohol-case-study
#5
Sapna Khowal, Samar Husain Naqvi, Seema Monga, Swatantra Kumar Jain, Saima Wajid
The intriguing molecular pathways involved in oral carcinogenesis are still ambiguous. The oral squamous cell carcinoma (OSCC) ranks as the most common type constituting more than 90% of the globally diagnosed oral cancers cases. The elevation in the OSCC incidence rate during past ten years has an alarming impression on human healthcare. The major challenges associated with OSCC include delayed diagnosis, high metastatic rates, and low five-year survival rates. The present work foundations on reverse genetic strategy and involves the identification of genes showing expressional variability in an OSCC case lacking addictive proclivities for tobacco, betel nut and/or alcohol, major etiologies...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29236276/5-ht7-receptors-are-over-expressed-in-patients-with-nasal-polyps
#6
Muhammed Yayla, Zekai Halici, Duygu Kose, Arzu Tatar, Mustafa Sitki Gozeler
Nasal polyposis (NP) is an inflammatory disease of the paranasal sinuses and nasal cavity. The primary purpose of our study is to determine the expression of 5-HT7 receptors both in nasal polyps and in healthy tissue in the nasal cavity. The subsequent aim is to compare the expression of 5-HT7 receptors in patients with NP and in inferior turbinate tissue (control). The study included 60 participants (40 with NP and 20 controls) aged 35 to 62 years. Nasal polyp samples were collected from all patients and relative 5-HT7 receptor expression analyses were performed...
December 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/29236227/loss-of-vascular-expression-of-nucleoside-triphosphate-diphosphohydrolase-1-cd39-in-hypertension
#7
Charlotte Roy, Julie Tabiasco, Antoine Caillon, Yves Delneste, Jean Merot, Julie Favre, Anne Laure Guihot, Ludovic Martin, Daniele C Nascimento, Bernhard Ryffel, Simon C Robson, Jean Sévigny, Daniel Henrion, Gilles Kauffenstein
Ectonucleoside triphosphate diphosphohydrolase-1, the major vascular/immune ectonucleotidase, exerts anti-thrombotic and immunomodulatory actions by hydrolyzing extracellular nucleotides (danger signals). Hypertension is characterized by vascular wall remodeling, endothelial dysfunction, and immune infiltration. Here our aim was to investigate the impact of arterial hypertension on CD39 expression and activity in mice. Arterial expression of CD39 was determined by reverse transcription quantitative real-time PCR in experimental models of hypertension, including angiotensin II (AngII)-treated mice (1 mg/kg/day, 21 days), deoxycorticosterone acetate-salt mice (1% salt and uninephrectomy, 21 days), and spontaneously hypertensive rats...
December 13, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/29236076/nucleobase-guanidiniocarbonyl-pyrrole-conjugates-as-novel-fluorimetric-sensors-for-single-stranded-rna
#8
Željka Ban, Biserka Žinić, Robert Vianello, Carsten Schmuck, Ivo Piantanida
We demonstrate here for the first time that a guanidiniocarbonyl-pyrrole (GCP) unit can be applied for the fine recognition of single stranded RNA sequences-an intuitively unexpected result since so far binding of the GCP unit to ds-DNA or ds-RNA relied strongly on minor or major groove interactions, as shown in previous work. Two novel nucleobase-GCP isosteric conjugates differing in the flexibility of GCP unit revealed a fluorimetric recognition of various single stranded RNA, which could be additionally regulated by pH...
December 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29236055/hyaluronan-production-by-renomedullary-interstitial-cells-influence-of-endothelin-angiotensin-ii-and-vasopressin
#9
Sara Stridh, Fredrik Palm, Tomoko Takahashi, Mayumi Ikegami-Kawai, Malou Friederich-Persson, Peter Hansell
The content of hyaluronan (HA) in the interstitium of the renal medulla changes in relation to body hydration status. We investigated if hormones of central importance for body fluid homeostasis affect HA production by renomedullary interstitial cells in culture (RMICs). Simultaneous treatment with vasopressin and angiotensin II (Ang II) reduced HA by 69%. No change occurred in the mRNA expressions of hyaluronan synthase 2 (HAS2) or hyaluronidases (Hyals), while Hyal activity in the supernatant increased by 67% and CD44 expression reduced by 42%...
December 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29236034/gastric-emptying-and-gastrointestinal-transit-compared-among-native-and-hydrolyzed-whey-and-casein-milk-proteins-in-an-aged-rat-model
#10
Julie E Dalziel, Wayne Young, Catherine M McKenzie, Neill W Haggarty, Nicole C Roy
Little is known about how milk proteins affect gastrointestinal (GI) transit, particularly for the elderly, in whom digestion has been observed to be slowed. We tested the hypothesis that GI transit is faster for whey than for casein and that this effect is accentuated with hydrolysates, similar to soy. Adult male rats (18 months old) were fed native whey or casein, hydrolyzed whey (WPH) or casein (CPH), hydrolyzed blend (HB; 60% whey:40% casein), or hydrolyzed soy for 14 days then treated with loperamide, prucalopride, or vehicle-control for 7 days...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29235926/effect-of-powdered-activated-carbon-dosage-on-sludge-properties-and-membrane-bioreactor-performance-in-a-hybrid-mbr-pac-system
#11
Shi Zhang, Xingtao Zuo, Juan Xiong, Cong Ma, Bo Hu
An improved insight into the effect of powdered activated carbon (PAC) on membrane fouling is crucial to the MBR performance. Sludge key property, soluble microbial products (SMP) and transmembrane pressure (TMP) were monitored. The membrane fouling rate in the MBRs was also analyzed based on TMP profile and resistance-in-series model. PAC reduced the membrane filtration resistance and significantly decreased the fouling rate. The sludge filterability was improved by extending the filtration time by almost two-fold...
December 13, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29235865/synergetic-catalysis-of-copper-and-iron-in-oxidation-of-reduced-keggin-heteropolytungstates-by-dioxygen
#12
Mooeung Kim, Masoumeh Chamack, Yurii V Geletii, Craig L Hill
Polyoxometalates (POMs) and in particularly Keggin heteropolytungstates are much studied and commercially important catalysts for dioxygen-based oxidation processes. The rate-limiting step in many POM-catalyzed O2-based oxidations is reoxidation of the reduced POM by O2. We report here that this reoxidation process, as represented by the one-electron-reduced Keggin complexes POMred (α-PW12O404- and α-SiVW11O406-) reacting with O2, is efficiently catalyzed by a combination of copper and iron complexes. The reaction kinetics and mechanism have been comprehensively studied in sulfate and phosphate buffer at pH 1...
December 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29235863/entrance-effects-induced-rectified-ionic-transport-in-a-nanopore-channel
#13
Yu Ma, Jinxiu Guo, Laibing Jia, Yanbo Xie
The nanofluidic diode, as one of the emerging nanofluidic logic devices, has been used in many fields such as biosensors, energy harvesting and so on. However, the entrance effects of the nanofluidic ionic conductance were less discussed, which can be a crucial factor for the ionic conduction. Here we calculate the ionic conductance as a function of the length-to-pore ratio (L/r), which has a clear boundary between nanopore (surface dominated) and nanochannel (geometry dominated) electrically in diluted salt solution...
December 13, 2017: ACS Sensors
https://www.readbyqxmd.com/read/29235844/injectable-and-degradable-ph-responsive-hydrogel-via-spontaneous-amino-yne-click-reaction
#14
Jiachang Huang, Xulin Jiang
Injectable hydrogels have attracted increasing attentions in tissue regeneration and local drug delivery applications. Current click reactions for preparing injectable hydrogel often require a photoinitiator or catalyst, which may be toxic and may involve complex synthesis of precursors. Here we report a facile and inexpensive method to prepare injectable and degradable hydrogels via spontaneous amino-yne click reaction without using any initiator or catalyst under physiological conditions based on telechelic electron-deficient dipropiolate ester of polyethylene glycol and water-soluble commercially available carboxymethyl chitosan...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235695/enzymatic-characterization-of-two-epsilon-class-glutathione-s-transferases-of-spodoptera-litura
#15
Aiko Hirowatari, Zhiwei Chen, Kazuei Mita, Kohji Yamamoto
Two cDNAs encoding glutathione S-transferase (GST) of the tobacco cutworm, Spodoptera litura, were cloned by reverse transcriptase-polymerase chain reaction. The deduced amino acid sequences of the resulting clones revealed 32-51% identities to the epsilon-class GSTs from other organisms. The recombinant proteins were functionally overexpressed in Escherichia coli cells in soluble form and were purified to homogeneity. The enzymes were capable of catalyzing the bioconjugation of glutathione with 1-chloro-2,4-dinitrobenzene, 1,2-epoxy-3-(4-nitrophenoxy)-propane, and ethacrynic acid...
December 13, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29235590/unravelling-the-hydrophobicity-of-urea-in-water-using-thermodiffusion-implications-for-protein-denaturation
#16
Doreen Niether, Silvia Di Lecce, Fernando Bresme, Simone Wiegand
Urea is widely used as a protein denaturant in aqueous solutions. Experimental and computer simulation studies have shown that it dissolves in water almost ideally at high concentrations, introducing little disruption in the water hydrogen bonded structure. However, at concentrations of the order of 5 M or higher, urea induces denaturation in a wide range of proteins. The origin of this behaviour is not completely understood, but it is believed to stem from a balance between urea-protein and urea-water interactions, with urea becoming possibly hydrophobic at a specific concentration range...
December 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29235570/targeting-negative-regulation-of-p53-by-mdm2-and-wip1-as-a-therapeutic-strategy-in-cutaneous-melanoma
#17
Chiao-En Wu, Arman Esfandiari, Yi-Hsuan Ho, Nan Wang, Ahmed Khairallah Mahdi, Erhan Aptullahoglu, Penny Lovat, John Lunec
BACKGROUND: Cutaneous melanoma is the most serious skin malignancy and new therapeutic strategies are needed for advanced melanoma. TP53 mutations are rare in cutaneous melanoma and hence activation of wild-type p53 is a potential therapeutic strategy in cutaneous melanoma. Here, we investigated the WIP1 inhibitor, GSK2830371, and MDM2-p53 binding antagonists (nutlin-3, RG7388 and HDM201) alone and in combination treatment in cutaneous melanoma cell lines and explored the mechanistic basis of these responses in relation to the genotype and induced gene expression profile of the cells...
December 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29235522/an-optogenetic-arrhythmia-model-to-study-catecholaminergic-polymorphic-ventricular-tachycardia-mutations
#18
Elisabeth Fischer, Alexander Gottschalk, Christina Schüler
Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a condition of abnormal heart rhythm (arrhythmia), induced by physical activity or stress. Mutations in ryanodine receptor 2 (RyR2), a Ca2+ release channel located in the sarcoplasmic reticulum (SR), or calsequestrin 2 (CASQ2), a SR Ca2+ binding protein, are linked to CPVT. For specific drug development and to study distinct arrhythmias, simple models are required to implement and analyze such mutations. Here, we introduced CPVT inducing mutations into the pharynx of Caenorhabditis elegans, which we previously established as an optogenetically paced heart model...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235521/infrared-actuation-induced-simultaneous-reconfiguration-of-surface-color-and-morphology-for-soft-robotics
#19
Seyedali Banisadr, Jian Chen
Cephalopods, such as cuttlefish, demonstrate remarkable adaptability to the coloration and texture of their surroundings by modulating their skin color and surface morphology simultaneously, for the purpose of adaptive camouflage and signal communication. Inspired by this unique feature of cuttlefish skins, we present a general approach to remote-controlled, smart films that undergo simultaneous changes of surface color and morphology upon infrared (IR) actuation. The smart film has a reconfigurable laminated structure that comprises an IR-responsive nanocomposite actuator layer and a mechanochromic elastomeric photonic crystal layer...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235498/computational-exploration-of-the-chemical-structure-space-of-possible-reverse-tricarboxylic-acid-cycle-constituents
#20
Markus Meringer, H James Cleaves
The reverse tricarboxylic acid (rTCA) cycle has been explored from various standpoints as an idealized primordial metabolic cycle. Its simplicity and apparent ubiquity in diverse organisms across the tree of life have been used to argue for its antiquity and its optimality. In 2000 it was proposed that chemoinformatics approaches support some of these views. Specifically, defined queries of the Beilstein database showed that the molecules of the rTCA are heavily represented in such compound databases. We explore here the chemical structure "space," e...
December 13, 2017: Scientific Reports
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