keyword
MENU ▼
Read by QxMD icon Read
search

Reversal

keyword
https://www.readbyqxmd.com/read/28231683/the-adverse-effects-of-exercise-and-supraphysiological-dose-of-testosterone-enanthate-te-on-exploratory-activity-in-elevated-plus-maze-epm-test-indications-for-using-total-exploratory-activity-tea-as-a-new-parameter-for-exploratory-activity-estimation-in-epm
#1
(no author information available yet)
OBJECTIVES: The aim of this study was the estimation of effects induced by chronic administration of supraphysiological dose of TE and prolonged exercise in male rats on anxiety levels (alterations in exploratory activity patterns in EPM). MATERIAL AND METHODS: Two sedentary (control - C and testosterone-enanthate - T) and two exercise (exercise - E and testosterone-enanthate plus exercise - T+E) groups (n=32) underwent adequate protocols - the swimming protocol (1 h/day) and TE (20 mg/kg/w, s...
October 24, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28231519/carotid-systolic-flow-time-with-passive-leg-raise-correlates-with-fluid-status-changes-in-patients-undergoing-dialysis
#2
Pavel Antiperovitch, Eduard Iliescu, Barry Chan
Corrected carotid systolic flow time (CFTc) has been proposed as a measure of volume status in acutely ill patients. This study endeavors to determine whether the change in CFTc with passive leg raise (PLR) maneuver correlates with volume status changes. Dialysis patients at Kingston General Hospital (Kingston, Canada) underwent point-of-care carotid ultrasonography at the beginning and the end of dialysis. With each measurement, 2 values were recorded: the absolute CFTc, and the difference in CFTc before and after the PLR maneuver...
February 10, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28231442/ethnomethodological-studies-of-nurse-patient-and-nurse-relative-interactions-a-scoping-review
#3
REVIEW
Eric Mayor, Lucas Bietti
OBJECTIVES: Researchers in nursing science interested in the study of nurse-patient and nurse-relative interactions have displayed an ever increasing interest in ethnomethodology and conversation analysis. This review assesses the scope of this literature. We categorize the papers in thematic categories determined both inductively and deductively and synthesize the main findings of this literature within category. Finally we discuss the interactional determinants of the lack patient participation, the limitations of the field, and focus on implications...
February 9, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28231318/effects-of-na-channel-blockers-on-the-restitution-of-refractory-period-conduction-time-and-excitation-wavelength-in-perfused-guinea-pig-heart
#4
Oleg E Osadchii
Na+ channel blockers flecainide and quinidine can increase propensity to ventricular tachyarrhythmia, whereas lidocaine and mexiletine are recognized as safe antiarrhythmics. Clinically, ventricular fibrillation is often precipitated by transient tachycardia that reduces action potential duration, suggesting that a critical shortening of the excitation wavelength (EW) may contribute to the arrhythmic substrate. This study examined whether different INa blockers can produce contrasting effects on the rate adaptation of the EW, which would explain the difference in their safety profile...
2017: PloS One
https://www.readbyqxmd.com/read/28231271/applying-antibody-sensitive-hypervariable-region-1-deleted-hepatitis-c-virus-to-the-study-of-escape-pathways-of-neutralizing-human-monoclonal-antibody-ar5a
#5
Rodrigo Velázquez-Moctezuma, Mansun Law, Jens Bukh, Jannick Prentoe
Hepatitis C virus (HCV) is a major cause of end-stage liver diseases. With 3-4 million new HCV infections yearly, a vaccine is urgently needed. A better understanding of virus escape from neutralizing antibodies and their corresponding epitopes are important for this effort. However, for viral isolates with high antibody resistance, or antibodies with moderate potency, it remains challenging to induce escape mutations in vitro. Here, as proof-of-concept, we used antibody-sensitive HVR1-deleted (ΔHVR1) viruses to generate escape mutants for a human monoclonal antibody, AR5A, targeting a rare cross-genotype conserved epitope...
February 23, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28231251/empirical-lessons-regarding-contraception-in-a-protracted-refugee-setting-a-descriptive-study-from-maela-camp-on-the-thai-myanmar-border-1996-2015
#6
Somjet Srikanok, Daniel M Parker, Amber L Parker, Tracey Lee, Aung Myat Min, Pranee Ontuwong, Saw Oo Tan, Supachai Sirinonthachai, Rose McGready
Conflict settings and refugee camps can be chaotic places, with large and rapid population movements, exacerbated public health problems, and ad hoc health services. Reproductive health care that includes family planning is of heightened importance in such settings, however, funding and resources tend to be constrained and geared towards acute health services such as trauma management and infectious disease containment. Here we report on the complexities and challenges of providing family planning in a post-emergency refugee setting, using the example of the largest refugee camp on the Thai-Myanmar border, in existence now for over 30 years...
2017: PloS One
https://www.readbyqxmd.com/read/28231234/notes-from-the-field-francisella-tularensis-type-b-infection-from-a-fish-hook-injury-minnesota-2016
#7
Tory Whitten, Jenna Bjork, Dave Neitzel, Kirk Smith, Maureen Sullivan, Joni Scheftel
On June 27, 2016, the Minnesota Department of Health (MDH) Public Health Laboratory (PHL) was notified of a suspected Francisella tularensis isolate cultured at a hospital laboratory. The isolate was confirmed as F. tularensis type B at MDH PHL by reverse transcription-polymerase chain reaction, culture, and direct fluorescent antibody testing. Francisella tularensis subspecies tularensis (type A) and holarctica (type B) bacteria are the causative agents of tularemia.
February 24, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28231162/phenolic-pro%C3%AF-le-and-antioxidant-activity-of-melon-cucumis-melo-l-seeds-from-pakistan
#8
Alam Zeb
Phenolic composition of different extracts of honeydew melon seeds and their antioxidant activity was determined for the first time. Phenolic compounds were identified using a reversed phase high performance liquid chromatography with diode array detection (HPLC-DAD) method. Results showed the identification of five phenolic compounds in water extract namely gallic acid and its derivative, hydroxybenzoic acid and catechin derivatives and caffeic acid.There were nine phenolic compounds identified in methanol-water extract, which are caffeic acid, two vanillic acid derivatives, ellagitanins, quercetin-3-rutinoside, derivatives of syringic acid and ellagic acid...
October 17, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231126/macular-pigment-optical-density-and-measures-of-macular-function-test-retest-variability-cross-sectional-correlations-and-findings-from-the-zeaxanthin-pilot-study-of-response-to-supplementation-zeastress-pilot
#9
Alessandro Iannaccone, Giovannella Carboni, Gina Forma, Maria Giulia Mutolo, Barbara J Jennings
We report on the short-term test-retest baseline variability in macular function tests in ZEASTRESS-Pilot participants (n = 18), on their cross-sectional correlation with macular pigment optical density (MPOD), and on the effects of four months (FUV4) of 20 mg/day zeaxanthin (ZX), followed by a four-month washout (FUV8; n = 24, age 50-81 years old). Outcomes included: MPOD at 0.5 and 2.0 deg eccentricity (MPOD-0.5 and -2.0); contrast sensitivity (CS); pattern-reversal electroretinogram (PERG) amplitude; dark-adapted 650 nm foveal cone sensitivity (DA650-FCS); and 500 mn parafoveal rod sensitivity (DA500-PFRS)...
April 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231034/upscaling-of-hips-cell-derived-neurons-for-high-throughput-screening
#10
Stefanie Traub, Heiko Stahl, Holger Rosenbrock, Eric Simon, Ralf Heilker
The advent of human-induced pluripotent stem (hiPS) cell-derived neurons promised to provide better model cells for drug discovery in the context of the central nervous system. This work demonstrates both the upscaling of cellular expansion and the acceleration of neuronal differentiation to accommodate the immense material needs of a high-throughput screening (HTS) approach. Using GRowth factor-driven expansion and INhibition of NotCH (GRINCH) during maturation, the derived cells are here referred to as GRINCH neurons...
March 2017: SLAS Discov
https://www.readbyqxmd.com/read/28231004/ionic-intercalation-in-2d-van-der-waals-materials-in-situ-characterization-and-electrochemical-control-of-the-anisotropic-thermal-conductivity-of-black-phosphorus
#11
Joon Sang Kang, Ming Ke, Yongjie Hu
Two-dimensional van der Waals materials have shown novel fundamental properties and promise for wide applications. Here, we reported, for the first time, an experimental demonstration of the in-situ characterization and control of the anisotropic thermal conductivity of black phosphorus. We develop a novel platform based on lithium ion batteries that integrates ultrafast optical spectroscopy and electrochemical control to investigate the interactions between lithium ions and the lattices of the black phosphorus electrode...
February 23, 2017: Nano Letters
https://www.readbyqxmd.com/read/28230998/influence-of-the-anomeric-conformation-in-the-intermolecular-interactions-of-glucose
#12
Imanol Usabiaga, Jorge González, Iker León, Pedro Felipe Arnaiz, Emilio J Cocinero, Jose A Fernandez
Carbohydrates are together with amino acids, DNA bases and lipids the building blocks of living beings. They play a central role in basic functions as immunity and signaling, which are governed by non-covalent interactions between sugar units and/or with other biomolecules. To get insights on such interactions between monosaccharide units, we used a combination of mass-resolved laser spectroscopy in supersonic expansions and molecular structure calculations. The results obtained clearly demonstrate that the small stability difference between the α/β anomers of glucopyranose derivatives is reversed and amplified during molecular aggregation, making the complexes of the β-anomers significantly more stable...
February 23, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28230994/artifact-free-and-detection-profile-independent-higher-order-fluorescence-correlation-spectroscopy-for-microsecond-resolved-kinetics-1-multi-detector-and-sub-binning-approach
#13
Farshad Abdollah-Nia, Martin P Gelfand, Alan K Van Orden
Fluorescence correlation spectroscopy (FCS) is a powerful tool in the time-resolved analysis of non-reacting or reacting molecules in solution, based on fluorescence intensity fluctuations. However, conventional (second-order) FCS alone is insufficient to measure all parameters needed to describe a reaction or mixture, including concentrations, fluorescence brightnesses, and forward and reverse rate constants. For this purpose, correlations of higher powers of fluorescence intensity fluctuations can be calculated to yield additional information from the single-photon data stream collected in an FCS experiment...
February 23, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28230974/femtogram-resolution-of-iron-content-on-a-per-cell-basis-ex-vivo-storage-of-human-red-blood-cells-leads-to-loss-of-hemoglobin
#14
Jeffrey J Chalmers, Xiaoxia Jin, Andre Francis Palmer, Peter Amaya, Mark H Yazer, Lee R Moore, Kyoung-Joo Park, X Jeff Pan, Maciej Zborowski
The magnetic characteristics of hemoglobin (Hb) changes with the binding of dioxygen (O2) to the heme prosthetic groups of the globin chains: from paramagnetic ferrous Hb to diamagnetic ferrous oxyhemoglobin (oxyHb) with reversibly bound O2, or paramagnetic ferric methemoglobin (metHb). When multiplied over the number of Hb molecules in a red blood cell (RBC), the effect is detectable through motion analysis of RBCs in a high magnetic field and gradient. This motion is referred to as magnetophoretic mobility which can be conveniently expressed as a fraction of the cell sedimentation coefficient...
February 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28230921/prevalence-of-promoter-mutations-in-the-tert-gene-in-oral-cavity-squamous-cell-carcinoma
#15
Kai-Ping Chang, Chun-I Wang, Curtis R Pickering, Yenlin Huang, Chi-Neu Tsai, Ngan-Ming Tsang, Huang-Kai Kao, Ming-Huei Cheng, Jeffrey N Myers
BACKGROUND: Mutations in the human telomerase reverse transcriptase (TERT) promoter contribute to increased TERT activity. The purpose of the present study was to assess the prevalence of TERT promoter mutations in oral cavity squamous cell carcinoma (SCC). METHODS: Total DNA was extracted from 201 oral cavity SCC tumors and adjacent normal tissues. Primers were used to amplify the sequence region containing 2 TERT promoter mutations (C228T and C250T) that were then sequenced using the Sanger method...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28230904/effects-of-re-heating-tissue-samples-to-core-body-temperature-on-high-velocity-ballistic-projectile-tissue-interactions
#16
Caitlin Humphrey, Maciej Henneberg, Christian Wachsberger, Nicholas Maiden, Jaliya Kumaratilake
Damage produced by high-speed projectiles on organic tissue will depend on the physical properties of the tissues. Conditioning organic tissue samples to human core body temperature (37°C) prior to conducting ballistic experiments enables their behavior to closely mimic that of living tissues. To minimize autolytic changes after death, the tissues are refrigerated soon after their removal from the body and re-heated to 37°C prior to testing. This research investigates whether heating 50-mm-cube samples of porcine liver, kidney, and heart to 37°C for varying durations (maximum 7 h) can affect the penetration response of a high-speed, steel sphere projectile...
February 23, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28230885/zwitterionic-indenylammonium-with-carbon-centred-reactivity-towards-reversible-co2-binding-and-catalytic-reduction
#17
Yanxin Yang, Linfan Yan, Qinyu Xie, Qiuming Liang, Datong Song
We report the synthesis and characterization of a zwitterionic indenylammonium compound and its carbon-centred reactivity towards reversible CO2 binding at ambient temperature through its formal insertion into a C-H bond as well as the catalytic hydroboration of CO2 to methanol derivatives.
February 23, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28230851/using-hiclip-to-identify-rna-duplexes-that-interact-with-a-specific-rna-binding-protein
#18
Yoichiro Sugimoto, Anob M Chakrabarti, Nicholas M Luscombe, Jernej Ule
The structure of RNA molecules has a critical role in regulating gene expression, largely through influencing their interactions with RNA-binding proteins (RBPs). RNA hybrid and individual-nucleotide resolution UV cross-linking and immunoprecipitation (hiCLIP) is a transcriptome-wide method of monitoring these interactions by identifying RNA duplexes bound by a specific RBP. The hiCLIP protocol consists of the following steps: in vivo cross-linking of RBPs to their bound RNAs; partial RNA digestion and purification of RNA duplexes interacting with the specific RBP using immunoprecipitation; ligation of the two arms of RNA duplexes via a linker; reverse transcription; cDNA library amplification; and finally high-throughput DNA sequencing...
March 2017: Nature Protocols
https://www.readbyqxmd.com/read/28230829/genetic-effects-in-children-exposed-in-prenatal-period-to-ionizing-radiation-after-the-chornobyl-nuclear-power-plant-accident
#19
Ye I Stepanova, V Yu Vdovenko, Zh A Misharina, V I Kolos, L P Mischenko
AIM: To study the genetic effects in children exposed to radiation in utero as a result of the Chornobyl nuclear power plant accident accounting the total radiation doses and equivalent radiation doses to the red bone marrow. MATERIALS AND METHODS: Incidence of minor developmental anomalies was studied in children exposed to radiation in utero (study group) and in the control group (1144 subjects surveyed in total). Cytogenetic tests using the method of differential G-banding of chromosomes were conducted in 60 children of both study and control groups (10-12-year-olds) and repeatedly in 39 adolescents (15-17-year-olds)...
December 2016: Experimental Oncology
https://www.readbyqxmd.com/read/28230828/chromosomal-mutagenesis-in-human-somatic-cells-30-year-cytogenetic-monitoring-after-chornobyl-accident
#20
M A Pilinska, G M Shemetun, O V Shemetun, S S Dybsky, O B Dybska, O O Talan, L R Pedan, D А Kurinnyi
In the lecture we have generalized and analyzed the data of cytogenetic laboratory of National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine on 30-year selective cytogenetic monitoring among the priority contingents of different ages exposed to radiation after Chornobyl accident in Ukraine. It is highlighted that not only targeted but also untargeted radiation-induced cytogenetic effects should be explored, especially in delayed terms following radiation exposure...
December 2016: Experimental Oncology
keyword
keyword
34313
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"