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"Betel nut"

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https://www.readbyqxmd.com/read/28182055/ultrastructural-analysis-of-oral-exfoliated-epithelial-cells-of-tobacco-smokers-and-betel-nut-chewers-a-scanning-electron-microscopy-study
#1
Sameera Shamim Khan, Balasundari Shreedhar, Mala Kamboj
BACKGROUND: The study was undertaken to correlate epithelial surface pattern changes of oral exfoliated cells of tobacco smokers and betel nut chewers and also to compare them with patients of oral squamous cell carcinoma (OSCC) and healthy individuals. MATERIALS AND METHODS: In this cross-sectional study, a total of fifty persons were included in the study, out of which thirty formed the study group (15 each tobacco smokers and betel nut chewers) and twenty formed the control group (ten each of OSCC patients - positive control and ten normal buccal mucosa - negative control)...
November 2016: Dental Research Journal
https://www.readbyqxmd.com/read/28152093/combined-effect-of-genetic-polymorphisms-of-aurka-and-environmental-factors-on-oral-cancer-development-in-taiwan
#2
Chia-Hsuan Chou, Ying-Erh Chou, Chun-Yi Chuang, Shun-Fa Yang, Chiao-Wen Lin
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the sixth and fourth most common cause of cancer death in men worldwide and in Taiwan, respectively. AURKA, which encodes a centrosome-related serine/threonine kinase, is frequently amplified and overexpressed in many human cancers, particularly advanced OSCC. We conducted a hospital-based case-control study to estimate AURKA single-nucleotide polymorphisms (SNPs) and environmental risk factors to determine OSCC susceptibility and clinicopathological characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28071638/smokeless-tobacco-use-and-perceptions-of-risk-among-students-in-mumbai-municipal-schools
#3
M L Rose, D Chadha, T D Bhutia
INTRODUCTION: Nearly 15% of youth in India use tobacco. However, few studies have explored the use, knowledge, and attitudes of smokeless tobacco use among youth. AIM: To determine the patterns of use as well as knowledge and perceptions of smokeless tobacco among youth in Mumbai attending municipal schools. MATERIALS AND METHODS: A cross-sectional survey was performed among 1053 students in the 8th and 9th grades in 16 municipal schools in Mumbai to determine the knowledge and perceptions about smokeless tobacco products as well as the patterns of use...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28019102/arecoline-aggravates-hypothyroidism-in-metabolic-stress-in-mice
#4
Romi Dasgupta, Aniruddha Chatterjee, Supriti Sarkar, B R Maiti
Millions of people consume betel nut for increased capacity of work. It contains arecoline which is highly toxic and has several untoward side effects on endocrine functions. In this article, the role of arecoline on thyroid function under metabolic stress was investigated in mice. Water or food-deprivation, each for 5 days, caused ultrastructural degeneration of thyro-follicular cells, evident from pycnotic nuclei, scanty rough endoplasmic reticulum and mitochondria followed by depletion of blood serum T3 and T4 levels with alteration of TSH level as compared with control...
December 26, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27997280/betel-nut-chewing-in-iron-age-vietnam-detection-of-areca-catechu-alkaloids-in-dental-enamel
#5
Simone Krais, Miriam Klima, Laura M Huppertz, Volker Auwärter, Markus J Altenburger, Merja A Neukamm
The betel quid is one of the most commonly consumed psychoactive substances in the world. By archaeological evidence like the occurrence of areca nuts in archaeological sites, the typical overall reddish-brown staining on prehistoric human teeth or specific artifacts linked with the habit, it is assumed that this tradition reaches back to prehistoric times. Since this kind of evidence is indirect, it is frequently doubted. The present study provides the earliest direct analytical indication of betel nut chewing in human history...
January 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27966506/versatility-of-nasolabial-flaps-for-the-management-of-severe-trismus-in-oral-submucous-fibrosis
#6
S M Balaji
BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic insidious disease affecting any part of the oral cavity and sometimes the pharynx. It is a collagen-related disorder predominantly associated with tobacco/areca nut chewing habit and characterized by progressive hyalinization of the submucosa. Prevalence of OSMF is 2.01%, and malignant transformation rate of 2.3%-7.6% has been reported in the literature. Measures such as forcing the mouth open and cutting the fibrotic bands have resulted in more fibrosis and disability...
September 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27924463/diagnostic-biomarkers-in-oral-verrucous-carcinoma-a-systematic-review
#7
REVIEW
Sepanta Hosseinpour, Fatemeh Mashhadiabbas, Mitra Ghazizadeh Ahsaie
Oral verrucous carcinoma (OVC), a low-grade variant of oral squamous cell carcinoma (OSCC), is most frequently seen in the oral cavity. No clear etiology has been found for this lesion, but human papilloma virus, chewing betel nuts, and ultraviolet radiation are suggested as probable causes. Differential diagnosis of OVC is challenging for oral pathologists. The aim of this study was to review the molecular-based approaches for differential diagnosis of OVC. An electronic search was conducted in Medline and Scopus from January 2004 to July 2015 limited to English language publications...
December 6, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27910776/molecular-pathology-of-malignant-transformation-of-oral-submucous-fibrosis
#8
REVIEW
Amit Chattopadhyay, Jay Gopal Ray
Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Transformation of OSF to squamous cell carcinoma (SCC) is variable, but up to 13% conversion of OSF to SCC has been reported. Various genetic and molecular mechanisms impact the malignant transformation of OSF, causing changes in the cell cycle, DNA, keratinocytes, and keratin; tumor-cell proliferation and survival; angiogenesis; fibrosis through epithelial-mesenchymal transitions (EMTs), and tissue hypoxia...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27891461/comparison-of-therapeutic-efficacy-of-placental-extract-with-dexamethasone-and-hyaluronic-acid-with-dexamethasone-for-oral-submucous-fibrosis-a-retrospective-analysis
#9
Palak Hasmukhbhai Shah, Rashmi Venkatesh, Chandramani Bhagawan More, Vaishnavee Vassandacoumara
INTRODUCTION: Oral Submucous Fibrosis (OSMF) is a potentially malignant disease of the oral cavity associated with betel nut chewing. The management of OSMF has been a subject of controversy and no definitive and widely accepted treatment is currently available for this condition. AIM: To retrospectively evaluate the therapeutic efficacy of two treatment regimens (placental extract with dexamethasone and hyaluronic acid with dexamethasone) for the treatment of OSMF...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889628/effect-of-betel-nut-chewing-on-the-otolithic-reflex-system
#10
Chuan-Yi Lin, Yi-Ho Young
OBJECTIVE: This study investigated the effect of betel nut chewing on the otolithic reflex system. METHODS: Seventeen healthy volunteers without any experience of chewing betel nut (fresh chewers) and 17 habitual chewers underwent vital sign measurements, ocular vestibular-evoked myogenic potential (oVEMP), and cervical VEMP (cVEMP) tests prior to the study. Each subject then chewed two pieces of betel nut for 2min (dosing). The same paradigm was repeated immediately, 10min, and 20min after chewing...
January 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27723638/prevalence-of-most-commonly-reported-tobacco-associated-lesions-in-central-gujarat-a-hospital-based-cross-sectional-study
#11
Manjiri Joshi, Mansi Tailor
BACKGROUND: Oral cancer is a major health problem in tobacco users worldwide and is one of the ten most common cancers. India alone accounts for 1/3 rd of the world's oral cancer and has a high rate of potentially malignant disorders (PMDs). The most common predisposing factors are smoking, smokeless tobacco, betel nut in quid form (pan), alcohol, spicy food, and sharp broken tooth. There are various tobacco-associated lesions (TALs) which can be diagnosed at very early stage. This study was conducted to rule out association of smoking and smokeless tobacco with occurrence of TALs and its dose-response relationship...
July 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27698910/increased-prevalence-of-esophageal-cancer-in-areas-with-high-levels-of-nickel-in-farm-soils
#12
Chien-Pang Lee, Yen-Hsin Lee, Ie-Bin Lian, Che-Chun Su
Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Objectives: We aimed to investigate whether these two cancers share some common risk factors. Methods: Taiwan began a compulsory national health insurance program in 1995. We used a database from this program to calculate the prevalence of EC and OC in Taiwan...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27681205/taking-actions-to-quit-chewing-betel-nuts-and-starting-a-new-life-taxi-drivers-successful-experiences-of-quitting-betel-nut-chewing
#13
Tsui-Yun Yang, Hung-Ru Lin
AIM AND OBJECTIVES: To understand taxi drivers' successful experiences of quitting betel nut chewing. BACKGROUND: Previous studies verified that betel nut chewing significantly increases the risk of oral cancer. In Taiwan, taxi drivers work for approximately 10-13 hours per day, and 31.7-80% of them choose to chew betel nuts for their invigorating qualities, which enable them to work more hours and receive more income. DESIGN: A qualitative research design was used...
September 29, 2016: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/27669306/novel-immunotherapeutic-approaches-for-head-and-neck-squamous-cell-carcinoma
#14
REVIEW
Darrin V Bann, Daniel G Deschler, Neerav Goyal
The immune system plays a key role in preventing tumor formation by recognizing and destroying malignant cells. For over a century, researchers have attempted to harness the immune response as a cancer treatment, although this approach has only recently achieved clinical success. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is associated with cigarette smoking, alcohol consumption, betel nut use, and human papillomavirus infection. Unfortunately, worldwide mortality from HNSCC remains high, partially due to limits on therapy secondary to the significant morbidity associated with current treatments...
September 22, 2016: Cancers
https://www.readbyqxmd.com/read/27644680/prevalence-and-factors-associated-with-oral-pre-malignant-lesions-in-northeast-thailand
#15
Narongrit Juntanong, Pallop Siewchaisakul, Peter Bradshaw, Patravoot Vatanasapt, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Tony Hsiu-Hsi Chen, Supannee Promthet
BACKGROUND: Oral cavity cancer (OCC) is one of the most common cancers worldwide. No studies have reported on the prevalence and epidemiologic risk factors of oral premalignant lesions (OPLs) in Thailand. The purpose of this study was to investigate the prevalence of OPLs and associated factors in Roi Et Province, Thailand. MATERIALS AND METHODS: To investigate the prevalence of OPLs, a cross-sectional descriptive study was conducted in which 2,300 subjects over 40 years of age were recruited and screened for the prevalence of OPLs...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27617049/giant-atretic-occipital-lipoencephalocele-in-an-adult-with-bony-outgrowth
#16
Kshama Nimkar, Dinesh Sood, Pawan Soni, Narvir Chauhan, Mukesh Surya
BACKGROUND: We present unique case of a giant extracranial atretic occipital lipoencephalocele in an adult patient with new bone formation within it which was not associated with any developmental malformation of brain. Resection of the lipoencephalocele was performed for esthetic reasons. CASE REPORT: 18 year old female patient presented to the surgery OPD with complains of a large mass in the occipital region present since birth. It was of size of a betel nut at the time of birth and gradually increased in size over a long period of time...
2016: Polish Journal of Radiology
https://www.readbyqxmd.com/read/27530080/evaluating-a-cobalt-tetraphenylporphyrin-complex-functionalized-with-a-reduced-graphene-oxide-nanocomposite-for-improved-tooth-whitening
#17
I-Hsuan Su, Chen-Fu Lee, Yu-Pin Su, Lai-Hao Wang
OBJECTIVES: To study using cobalt-tetraphenylporphyrin/reduced graphene oxide (CoTPP/RGO), a nanocomposite highly catalytic both for oxidizing and for reducing hydrogen peroxide (H2 O2 ), to whiten teeth. METHODS: Dyes (D&C Red 34, Orange No. 4), tea, and betel nuts (Areca catechu) were used to stain the tooth specimens for three days and subsequently bleached using H2 O2 alone, H2 O2 plus CoTPP, or H2 O2 plus CoTPP/RGO for 0.5-70 hours. The process was photographed using an electronic chromometer and a camera...
September 2016: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/27463966/adamts14-gene-polymorphism-and-environmental-risk-in-the-development-of-oral-cancer
#18
Shih-Chi Su, Ming-Ju Hsieh, Yu-Fan Liu, Ying-Erh Chou, Chiao-Wen Lin, Shun-Fa Yang
BACKGROUND: Oral cancer is a common malignancy that is shown to be causally associated with hereditary and acquired factors. ADAMTS14 is a member of the ADAMTS (a disintegrin-like and metalloproteinase domain with thrombospondin motifs) metalloproteinase family that plays an important role in extracellular matrix (ECM) assembly and degradation. Elevation or deficiency of certain ADAMTS proteinases has been known to be implicated in a wide range of pathological processes including atherosclerosis, arthritis, and cancer...
2016: PloS One
https://www.readbyqxmd.com/read/27292527/buccal-mucosa-elasticity-influences-surgical-margin-determination-in-buccal-carcinoma-resection
#19
Pai-Tai Tsai, Yi-Shing Shieh, Chi-Tsung Wu, Shiao-Pieng Lee, Yuan-Wu Chen
PURPOSE: Little is known about whether buccal mucosa elasticity influences the determination of surgical margins for buccal carcinomas. This study investigated whether there is a difference in elasticity of the buccal mucosa in patients with buccal carcinoma compared with controls without the disease. PATIENTS AND METHODS: A case-and-control study comprised of patients with buccal carcinoma and controls without the disease was conducted. In each patient, 2 gutta-percha points were attached to the buccal mucosa horizontally and examined twice by lateral cephalometry, once with the mouth closed and once during maximal mouth opening (MMO)...
September 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27285985/microrna-17-5p-regulated-apoptosis-related-protein-expression-and-radiosensitivity-in-oral-squamous-cell-carcinoma-caused-by-betel-nut-chewing
#20
Szu-Yuan Wu, Alexander T H Wu, Shing-Hwa Liu
Betel nut chewing is associated with oral cavity cancer. Radiotherapy is one of the therapeutic approaches. Here, we used miR-17-5p antisense oligonucleotides (AS-ODNs) and human apoptosis protein array to clarify which apoptosis-related proteins are increased or decreased by miR-17-5p in betel nut chewing- oral squamous cell carcinoma OC3 cells. Furthermore, miR-17-5p AS-ODN was used to evaluate the radio-sensitization effects both in vitro and in vivo. An OC3 xenograft tumor model in severe combined immunodeficiency mice was used to determine the effect of miR-17-5p AS ODN on tumor irradiation...
August 9, 2016: Oncotarget
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