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https://www.readbyqxmd.com/read/28426731/effect-of-genetic-variation-in-microrna-binding-site-in-wnt1-inducible-signaling-pathway-protein-1-gene-on-oral-squamous-cell-carcinoma-susceptibility
#1
Hon-Kit Lau, Edie-Rosmin Wu, Mu-Kuan Chen, Ming-Ju Hsieh, Shun-Fa Yang, Lyu-Yao Wang, Ying-Erh Chou
BACKGROUND: Oral squamous cell carcinoma (OSCC), which is the most common head and neck cancer, accounts for 1%-2% of all human malignancies and is characterized by poor prognosis and reduced survival rates. WNT1-inducible signaling pathway protein 1 (WISP1), a cysteine-rich protein belonging to the Cyr61, CTGF, Nov (CCN) family of matricellular proteins, has many developmental functions and may be involved in carcinogenesis. This study investigated WISP1 single-nucleotide polymorphisms (SNPs) to elucidate OSCC susceptibility and clinicopathologic characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28404909/impact-of-ccl4-gene-polymorphisms-and-environmental-factors-on-oral-cancer-development-and-clinical-characteristics
#2
Ming-Yu Lien, Chiao-Wen Lin, Hsiao-Chi Tsai, Yng-Tay Chen, Ming-Hsui Tsai, Chun-Hung Hua, Shun-Fa Yang, Chih-Hsin Tang
In Taiwan, oral cancer has causally been associated with environmental carcinogens. CCL4 (C-C chemokine ligand 4), a macrophage inflammatory protein with a key role in inflammation and immune-regulation, was implicated in carcinogenesis by facilitating instability in the tumor environment. The purpose of this study was to identify gene polymorphisms of CCL4 specific to patients with oral squamous cell carcinoma (OSCC) susceptibility and clinicopathological characteristics. A total of 2,053 participants, including 1192 healthy people and 861 patients with oral cancer, were recruited for this study...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28383824/implication-for-second-primary-cancer-from-visible-oral-and-oropharyngeal-premalignant-lesions-in-betel-nut-chewing-related-oral-cancer
#3
Shyun-Yu Liu, I-Jung Feng, Yu-Wei Wu, Ching-Yuan Chen, Chao-Nan Hsiung, Hsueh-Wei Chang, Che-Yi Lin, Min-Te Chang, Hsi-Chien Yu, Sheng-Yang Lee, Ching-Yu Yen
BACKGROUND: Visible oral and oropharyngeal premalignant lesions may be used to monitor for a second primary oral cancer. To control for bias, we focused on the visible oral and oropharyngeal premalignant lesions of patients with oral cancer with a positive betel-nut chewing habit. Visible oral and oropharyngeal premalignant lesions that can predict second primary oral cancers were studied. METHODS: Nine hundred ninety-seven patients with positive betel-nut chewing habits and oral cancer were enrolled in this retrospective cohort study...
April 6, 2017: Head & Neck
https://www.readbyqxmd.com/read/28317358/-epidemiological-investigation-of-chewing-fresh-or-dried-betel-nut-and-oral-mucosal-disease
#4
Du Yongxiu, Sun Dongye, Jian Xinchun, Mao Qiuhua, Cheng Yanan, Xu Pu
OBJECTIVE: This study was conducted to investigate the effect of chewing fresh or dried betel nut on the inci-dence and canceration of oral mucosa disease in Haikou City in Hainan Province. METHODS: Through a survey questionnaire, clinical examination, and regular follow-up, we collected clinical data from 1 722 cases and divided them into two groups, among which 704 of the afflicted people chew dried betel nut, whereas the other 1 018 chew fresh betel nut. The data were 
statistically analyzed using different variables which included age, number, time of onset of the disease, and the cancerous condition associated with common oral mucosa disease, including oral submucous fibrosis (OSF), oral leukoplakia (OLK), and oral Lichen planus (OLP)...
August 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28278615/in-vitro-cholinesterase-inhibitory-activity-of-some-plants-used-in-iranian-traditional-medicine
#5
Mina Saeedi, Khatereh Babaie, Elahe Karimpour-Razkenari, Mahdi Vazirian, Tahmineh Akbarzadeh, Mahnaz Khanavi, Mannan Hajimahmoodi, Mohammad Reza Shams Ardekani
In this study, in vitro evaluation of cholinesterase inhibitory (ChEI) activity of various plants including betel nuts (Areca catechu L.), clove buds (Syzygium aromaticum L.), aerial parts of dodder (Cuscuta chinensis Lam.), common polypody rhizomes (Polypodium vulgare L.) and turpeth roots (Ipomoea turpethum R. Br.) which were recommended for the treatment of AD symptoms in Iranian Traditional Medicine (ITM) is reported. Among them, aqueous extract of A. catechu L. was found as the most potent anti-AChE (IC50 = 32...
March 6, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28277392/impaired-kidney-function-and-associated-factors-among-rural-adults-with-disabilities-in-taiwan
#6
Chu-Yeh Chen, Wen-Nan Chiu, Yu-Chen Lin, Sui-Hwi Jane, Hsin-Hung Chiang, Mei-Yen Chen
BACKGROUND: The results of numerous studies indicate that people with disabilities seek more healthcare than those who are not disabled, particularly for conditions such as chronic kidney disease, cardiovascular disease, and obesity. However, little is known about the incidence of impaired kidney function and its associated factors among adults with disabilities in Taiwan. PURPOSE: The aim of this study was to explore the prevalence and factors associated with impaired kidney function among adults with disabilities...
April 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28272042/utilization-of-two-agrowastes-for-adsorption-and-removal-of-methylene-blue-kinetics-and-isotherm-studies
#7
Manash Deep Dey, Minhaz Ahmed, Ranjana Singh, Ratan Boruah, Rupak Mukhopadhyay
Fresh water streams contaminated with synthetic dye-containing effluents pose a threat to aquatic and human life either by preventing aquatic photosynthesis or by entering into the food chain. Adsorptive removal of such dyes with potent biosorbents is an important technique to reduce bioaccumulation and biomagnifications of the dyes in human life. We report use of betel nut (BN) husk and banana peel (BP), two most abundant ligno-cellulosic wastes, as efficient adsorbents for the removal of the basic dye methylene blue (MB)...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28265049/the-ethics-of-betel-nut-consumption-in-taiwan
#8
Joseph Tham, Geoffrey Sem, Eugene Sit, Michael Cheng-Tek Tai
The ethics of betel nut use in Taiwan are examined in this article. It first presents scientific facts about the betel quid, its consumption and negative health consequences and then analyses the cultural background and economic factors contributing to its popularity in Asia. Governmental and institutional attempts to curb betel nut cultivation, distribution and sales are also described. Finally, the bioethical implications of this often ignored subject are considered.
March 6, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28230921/prevalence-of-promoter-mutations-in-the-tert-gene-in-oral-cavity-squamous-cell-carcinoma
#9
Kai-Ping Chang, Chun-I Wang, Curtis R Pickering, Yenlin Huang, Chi-Neu Tsai, Ngan-Ming Tsang, Huang-Kai Kao, Ming-Huei Cheng, Jeffrey N Myers
BACKGROUND: Mutations in the human telomerase reverse transcriptase (TERT) promoter contribute to increased TERT activity. The purpose of the present study was to assess the prevalence of TERT promoter mutations in oral cavity squamous cell carcinoma (SCC). METHODS: Total DNA was extracted from 201 oral cavity SCC tumors and adjacent normal tissues. Primers were used to amplify the sequence region containing 2 TERT promoter mutations (C228T and C250T) that were then sequenced using the Sanger method...
February 23, 2017: Head & Neck
https://www.readbyqxmd.com/read/28225785/betel-nut-chewing-oral-premalignant-lesions-and-the-oral-microbiome
#10
Brenda Y Hernandez, Xuemei Zhu, Marc T Goodman, Robert Gatewood, Paul Mendiola, Katrina Quinata, Yvette C Paulino
Oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (HPV), and areca (betel) nut. Although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. An investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. Study participants were recruited from a dental clinic in Guam. Structured interviews and oral examinations were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28219593/betel-nut-chewing-is-associated-with-reduced-tacrolimus-concentration-in-taiwanese-liver-transplant-recipients
#11
W-Y Chen, C-Y Lee, P-Y Lin, C-E Hsieh, C-J Ko, K-H Lin, C-C Lin, Y-Z Ming, Y-L Chen
PURPOSE: Studies have shown that arecoline, the major alkaloid component of betel nuts, alters the activity of enzymes in the cytochrome P450 (CYP-450) family. Tacrolimus, an immunosuppressant that protects against organ rejection in transplant recipients, not only is mainly metabolized by CYP3A enzymes but also has a narrow therapeutic range. We aimed to investigate whether dose-adjusted blood trough levels of tacrolimus differed over time between betel nut-chewing and non-betel nut-chewing liver transplant recipients...
March 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28182055/ultrastructural-analysis-of-oral-exfoliated-epithelial-cells-of-tobacco-smokers-and-betel-nut-chewers-a-scanning-electron-microscopy-study
#12
Sameera Shamim Khan, Balasundari Shreedhar, Mala Kamboj
BACKGROUND: The study was undertaken to correlate epithelial surface pattern changes of oral exfoliated cells of tobacco smokers and betel nut chewers and also to compare them with patients of oral squamous cell carcinoma (OSCC) and healthy individuals. MATERIALS AND METHODS: In this cross-sectional study, a total of fifty persons were included in the study, out of which thirty formed the study group (15 each tobacco smokers and betel nut chewers) and twenty formed the control group (ten each of OSCC patients - positive control and ten normal buccal mucosa - negative control)...
November 2016: Dental Research Journal
https://www.readbyqxmd.com/read/28152093/combined-effect-of-genetic-polymorphisms-of-aurka-and-environmental-factors-on-oral-cancer-development-in-taiwan
#13
Chia-Hsuan Chou, Ying-Erh Chou, Chun-Yi Chuang, Shun-Fa Yang, Chiao-Wen Lin
BACKGROUND: Oral squamous cell carcinoma (OSCC) is the sixth and fourth most common cause of cancer death in men worldwide and in Taiwan, respectively. AURKA, which encodes a centrosome-related serine/threonine kinase, is frequently amplified and overexpressed in many human cancers, particularly advanced OSCC. We conducted a hospital-based case-control study to estimate AURKA single-nucleotide polymorphisms (SNPs) and environmental risk factors to determine OSCC susceptibility and clinicopathological characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28071638/smokeless-tobacco-use-and-perceptions-of-risk-among-students-in-mumbai-municipal-schools
#14
M L Rose, D Chadha, T D Bhutia
INTRODUCTION: Nearly 15% of youth in India use tobacco. However, few studies have explored the use, knowledge, and attitudes of smokeless tobacco use among youth. AIM: To determine the patterns of use as well as knowledge and perceptions of smokeless tobacco among youth in Mumbai attending municipal schools. MATERIALS AND METHODS: A cross-sectional survey was performed among 1053 students in the 8th and 9th grades in 16 municipal schools in Mumbai to determine the knowledge and perceptions about smokeless tobacco products as well as the patterns of use...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28019102/arecoline-aggravates-hypothyroidism-in-metabolic-stress-in-mice
#15
Romi Dasgupta, Aniruddha Chatterjee, Supriti Sarkar, B R Maiti
Millions of people consume betel nut for increased capacity of work. It contains arecoline which is highly toxic and has several untoward side effects on endocrine functions. In this article, the role of arecoline on thyroid function under metabolic stress was investigated in mice. Water or food-deprivation, each for 5 days, caused ultrastructural degeneration of thyro-follicular cells, evident from pycnotic nuclei, scanty rough endoplasmic reticulum and mitochondria followed by depletion of blood serum T3 and T4 levels with alteration of TSH level as compared with control...
May 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27997280/betel-nut-chewing-in-iron-age-vietnam-detection-of-areca-catechu-alkaloids-in-dental-enamel
#16
Simone Krais, Miriam Klima, Laura M Huppertz, Volker Auwärter, Markus J Altenburger, Merja A Neukamm
The betel quid is one of the most commonly consumed psychoactive substances in the world. By archaeological evidence like the occurrence of areca nuts in archaeological sites, the typical overall reddish-brown staining on prehistoric human teeth or specific artifacts linked with the habit, it is assumed that this tradition reaches back to prehistoric times. Since this kind of evidence is indirect, it is frequently doubted. The present study provides the earliest direct analytical indication of betel nut chewing in human history...
January 2017: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27966506/versatility-of-nasolabial-flaps-for-the-management-of-severe-trismus-in-oral-submucous-fibrosis
#17
S M Balaji
BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic insidious disease affecting any part of the oral cavity and sometimes the pharynx. It is a collagen-related disorder predominantly associated with tobacco/areca nut chewing habit and characterized by progressive hyalinization of the submucosa. Prevalence of OSMF is 2.01%, and malignant transformation rate of 2.3%-7.6% has been reported in the literature. Measures such as forcing the mouth open and cutting the fibrotic bands have resulted in more fibrosis and disability...
September 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/27924463/diagnostic-biomarkers-in-oral-verrucous-carcinoma-a-systematic-review
#18
REVIEW
Sepanta Hosseinpour, Fatemeh Mashhadiabbas, Mitra Ghazizadeh Ahsaie
Oral verrucous carcinoma (OVC), a low-grade variant of oral squamous cell carcinoma (OSCC), is most frequently seen in the oral cavity. No clear etiology has been found for this lesion, but human papilloma virus, chewing betel nuts, and ultraviolet radiation are suggested as probable causes. Differential diagnosis of OVC is challenging for oral pathologists. The aim of this study was to review the molecular-based approaches for differential diagnosis of OVC. An electronic search was conducted in Medline and Scopus from January 2004 to July 2015 limited to English language publications...
January 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27910776/molecular-pathology-of-malignant-transformation-of-oral-submucous-fibrosis
#19
REVIEW
Amit Chattopadhyay, Jay Gopal Ray
Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Transformation of OSF to squamous cell carcinoma (SCC) is variable, but up to 13% conversion of OSF to SCC has been reported. Various genetic and molecular mechanisms impact the malignant transformation of OSF, causing changes in the cell cycle, DNA, keratinocytes, and keratin; tumor-cell proliferation and survival; angiogenesis; fibrosis through epithelial-mesenchymal transitions (EMTs), and tissue hypoxia...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27891461/comparison-of-therapeutic-efficacy-of-placental-extract-with-dexamethasone-and-hyaluronic-acid-with-dexamethasone-for-oral-submucous-fibrosis-a-retrospective-analysis
#20
Palak Hasmukhbhai Shah, Rashmi Venkatesh, Chandramani Bhagawan More, Vaishnavee Vassandacoumara
INTRODUCTION: Oral Submucous Fibrosis (OSMF) is a potentially malignant disease of the oral cavity associated with betel nut chewing. The management of OSMF has been a subject of controversy and no definitive and widely accepted treatment is currently available for this condition. AIM: To retrospectively evaluate the therapeutic efficacy of two treatment regimens (placental extract with dexamethasone and hyaluronic acid with dexamethasone) for the treatment of OSMF...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
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