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https://www.readbyqxmd.com/read/29120831/epidemiology-of-areca-betel-nut-use-in-the-mariana-islands-findings-from-the-university-of-guam-university-of-hawai-i-cancer-center-partnership-program
#1
Yvette C Paulino, Eric L Hurwitz, Joanne C Ogo, Tristan C Paulino, Ashley B Yamanaka, Rachel Novotny, Lynne R Wilkens, Mary Jane Miller, Neal A Palafox
BACKGROUND: Areca (betel) nut is considered a Group 1 human carcinogen shown to be associated with other chronic diseases in addition to cancer. This paper describes the areca (betel) nut chewing trend in Guam, and health behaviors of chewers in Guam and Saipan. METHODS: The areca (betel) nut module in the Guam Behavioral Risk Factor Surveillance Survey was used to calculate the 5-year (2011-2015) chewing trend. To assess the association between areca (betel) nut chewing and health risks in the Mariana Islands, a cross-section of 300 chewers, ≥18years old, were recruited from households in Guam and Saipan...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29120830/areca-betel-nut-chewing-practices-of-adults-and-health-behaviors-of-their-children-in-the-freely-associated-states-micronesia-findings-from-the-children-s-healthy-living-chl-program
#2
Yvette C Paulino, Reynolette Ettienne, Rachel Novotny, Lynne R Wilkens, Moria Shomour, Cecilia Sigrah, Shelley D Remengesau, Emihner L Johnson, Julia M Alfred, Daisy F Gilmatam
BACKGROUND: Chewing areca (betel) nut has been deemed carcinogenic. The practice has become a public health concern in Micronesia. The Children's Healthy Living (CHL) Program included an areca (betel) nut questionnaire in a survey of household characteristics in the Freely Associated States (FAS). This paper describes areca (betel) nut chewing practices of adults and the health behaviors of their children. METHODS: A cross-section of 1200 children (2-8 year-olds) and their caregivers in Chuuk, Kosrae, Pohnpei, Republic of Palau, Republic of the Marshall Islands (RMI), and Yap were recruited...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29120829/risk-factors-for-breast-cancer-in-the-breast-cancer-risk-model-study-of-guam-and-saipan
#3
Rachael T Leon Guerrero, Rachel Novotny, Lynne R Wilkens, Marie Chong, Kami K White, Yurii B Shvetsov, Arielle Buyum, Grazyna Badowski, Michelle Blas-Laguaña
BACKGROUND: Chamorro Pacific Islanders in the Mariana Islands have breast cancer incidence rates similar to, but mortality rates higher than, those of U.S. women. As breast cancer risk factors of women of the Mariana Islands may be unique because of ethnic and cultural differences, we studied established and suspected risk factors for breast cancer in this unstudied population. METHODS: From 2010-2013, we conducted retrospective case-control study of female breast cancer (104 cases and 185 controls) among women in the Mariana Islands...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29120826/cancer-in-guam-and-hawaii-a-comparison-of-two-u-s-island-populations
#4
Brenda Y Hernandez, Renata A Bordallo, Michael D Green, Robert L Haddock
BACKGROUND: Cancer disparities within and across populations provide insight into the influence of lifestyle, environment, and genetic factors on cancer risk. METHODS: Guam cancer incidence and mortality were compared to that of Hawaii using data from their respective population-based, central cancer registries. RESULTS: In 2009-2013, overall cancer incidence was substantially lower in Guam than in Hawaii for both sexes while overall cancer mortality was higher for Guam males...
October 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29072384/-global-incidence-and-risk-factors-of-oral-cancer
#5
REVIEW
Yasmine Ghantous, Imad Abu Elnaaj
INTRODUCTION: Cancer of the oral cavity (Oral cancer) is the 11th most common malignancy in the world. Despite the general global trend of a slight decrease in the incidence of oral cancer, tongue cancer incidence is increasing. The incidence and mortality caused by this tumor show variability according to the geographic location in which it is diagnosed. However, in the last decade an increase was observed in the percentage of young patients, especially patients with tongue cancer. The main risk factors of head and neck cancer worldwide are smoking and alcohol, as well as DNA oncogenic viruses and habits, such as betel nut...
October 2017: Harefuah
https://www.readbyqxmd.com/read/29059390/cracking-the-betel-nut-cholinergic-activity-of-areca-alkaloids-and-related-compounds
#6
Nicole A Horenstein, Marta Quadri, Clare Stokes, Mohammed Shoaib, Roger L Papke
Introduction: The use of betel quid is the most understudied major addiction in the world. The neuropsychological activity of betel quid has been attributed to alkaloids of Areca catechu. With the goal of developing novel addiction treatments, we evaluate the muscarinic and nicotinic activity of the four major Areca alkaloids: arecoline, arecaidine, guvacoline, and guvacine and four structurally related compounds. Methods: Acetylcholine receptors were expressed in Xenopus oocytes and studied with two-electrode voltage clamp...
October 3, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29038963/lymph-node-density-as-a-prognostic-predictor-in-patients-with-betel-nut-related-oral-squamous-cell-carcinoma
#7
Wei-Chin Chang, Chun-Shu Lin, Cheng-Yu Yang, Chih-Kung Lin, Yuan-Wu Chen
OBJECTIVES: Lymph node metastasis in oral squamous cell carcinoma (OSCC) is a poor prognostic factor. The histopathologic stage (e.g., pN) is used to evaluate the severity of lymph node metastasis; however, the current staging system insufficiently predicts survival and recurrence. We investigated clinical outcomes and lymph node density (LND) in betel nut-chewing individuals. MATERIAL AND METHODS: We retrospectively analyzed 389 betel nut-exposed patients with primary OSCC who underwent surgical resection in 2002-2015...
October 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28994647/factors-influencing-the-initiation-of-smokeless-tobacco-consumption-among-low-socioeconomic-community-in-bangladesh-a-qualitative-investigation
#8
Md Shahjahan, Md Golam Dostogir Harun, A B M Alauddin Chowdhury, Kapil Ahmed, Hafiz T A Khan
This study explored factors influencing the initiation of smokeless tobacco (SLT) consumption in a low socioeconomic urban community in Bangladesh. The study conducted four focus group discussions among 33 informants involves school teachers, community leaders, women, and betel-nut shops owners. The results were prepared by thematic analysis of the transcripts where informants mean age was 30 ( SD ± 6.8) years with varying level of education. Tradition of hospitality, curiosity, offer from an elderly person, and avoiding nausea during pregnancy and at time of quitting smoking were key factors for the initiation of SLT consumption...
January 1, 2017: International Quarterly of Community Health Education
https://www.readbyqxmd.com/read/28939077/genomic-characterization-of-tobacco-nut-chewing-hpv-negative-early-stage-tongue-tumors-identify-mmp10-asa-candidate-to-predict-metastases
#9
Pawan Upadhyay, Nilesh Gardi, Sanket Desai, Pratik Chandrani, Asim Joshi, Bhaskar Dharavath, Priyanca Arora, Munita Bal, Sudhir Nair, Amit Dutt
OBJECTIVES: Nodal metastases status among early stage tongue squamous cell cancer patients plays a decisive role in the choice of treatment, wherein about 70% patients can be spared from surgery with an accurate prediction of negative pathological lymph node status. This underscores an unmet need for prognostic biomarkers to stratify the patients who are likely to develop metastases. MATERIALS AND METHODS: We performed high throughput sequencing of fifty four samples derived from HPV negative early stage tongue cancer patients habitual of chewing betel nuts, areca nuts, lime or tobacco using whole exome (n=47) and transcriptome (n=17) sequencing that were analyzed using in-house computational tools...
October 2017: Oral Oncology
https://www.readbyqxmd.com/read/28837085/consumption-of-energy-drinks-among-undergraduate-students-in-taiwan-related-factors-and-associations-with-substance-use
#10
Yen-Jung Chang, Ching-Yi Peng, Yu-Ching Lan
Background: This study aimed to investigate the consumption of energy drinks and associated factors among undergraduate students in Taiwan. Methods: Data came from a cross-sectional survey conducted in 2015. Eligible participants completed a self-administered questionnaire assessing use and perceptions of energy drinks, tobacco, alcohol, and betel nut. Results: Among 606 surveyed undergraduate students, 24.8% reported consuming energy drinks in the past 30 days. The major reasons for use included keeping alert at work (48...
August 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28831213/cuticular-surface-damage-of-ascaridia-galli-adult-worms-treated-with-veitchia-merrillii-betel-nuts-extract-in-vitro
#11
Ummu Balqis, Muhammad Hambal, Rinidar, Farida Athaillah, Ismail, Azhar, Henni Vanda, Darmawi
AIM: The objective of this research was to in vitro evaluate the cuticular surface damage of Ascaridia galli adult worms treated with ethanolic extract of betel nuts Veitchia merrillii. MATERIALS AND METHODS: Phytochemical screening was done using FeCl3, Wagner and Dragendorff reagents, NaOH, MgHCl, and Liebermann-Burchard reaction test. Amount of 16 worms were segregated into four groups with three replicates. Four worms of each group submerged into phosphate buffered saline, 25 mg/ml, and 75 mg/ml crude ethanolic extract of V...
July 2017: Veterinary World
https://www.readbyqxmd.com/read/28828766/perspective-on-health-seeking-behavior-of-patients-with-oropharyngeal-cancers-from-a-pakistani-background
#12
Maria Shoaib, Syed Ahsanuddin Ahmed, Syed Muhammad Waqar, Zainab Abbasi, Farah Hafiz Yusuf
Oropharyngeal cancers are the most common cancers of head neck region, they are placed amongst the top ten malignancies globally and around 40% of all the cancers in South and South East Asia. Patient's personal behaviour impacts causality more than the environmental factors in the pathology and prognosis of this particular cancer. In our country risk factors are based on poor infrastructure of the health care system, illiteracy, poor socioeconomic status, Betel nut and quid, smokeless and smoke tobacco. We recommend that an active precautionary approach is required to restrict the rising incidence in the oral cancers, particularly due to culturally related risk habits and reluctance to seek early healthcare amongst our people...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28758200/endoscopic-screening-for-synchronous-esophageal-neoplasia-among-patients-with-incident-head-and-neck-cancer-prevalence-risk-factors-and-outcomes
#13
Yao-Kuang Wang, Yun-Shiuan Chuang, Tzung-Shiun Wu, Ka-Wo Lee, Che-Wei Wu, Hsiang-Chen Wang, Chie-Tong Kuo, Chien-Hung Lee, Wen-Rei Kuo, Chung-Ho Chen, Deng-Chyang Wu, I-Chen Wu
Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients were prospectively recruited for endoscopy screening for ESCN using white-light imaging, narrow-band imaging, Lugol chromoendoscopy, and pathological confirmation. Associated lifestyle and clinicopathological data were collected...
November 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28756939/bacteriology-of-peritonsillar-abscess-the-changing-trend-and-predisposing-factors
#14
Yi-Wen Tsai, Yu-Hsi Liu, Hsing-Hao Su
INTRODUCTION: Peritonsillar abscess is the most common deep neck infection. The infectious microorganism may be different according to clinical factors. OBJECTIVE: To identify the major causative pathogen of peritonsillar abscess and investigate the relationship between the causative pathogen, host clinical factors, and hospitalization duration. METHODS: This retrospective study included 415 hospitalized patients diagnosed with peritonsillar abscess who were admitted to a tertiary medical center from June 1990 to June 2013...
July 17, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28731854/oral-submucous-fibrosis-in-a-school-going-indian-adolescent-boy
#15
Vishal Khandelwal, Hallaswamy V Kambalimath, Naveen B Reddy, Sushma Khandelwal, Vanaja Reddy, Nitu Gupta
A 14-year-old boy presented to our hospital with a chief complaint of difficulty in opening his mouth and a burning sensation on eating spicy food. The oral mucosa showed generalized diffused blanching and he was unable to protrude his tongue. For 6 years he had habitually chewed gutkha - a mixture of betel nut and tobacco for several minutes a day. This oral submucous fibrosis condition is very rare in young patients. The case highlights the link between oral submucous fibrosis and the regular use of areca nut (gutkha) products in a young boy...
July 21, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28704075/arecoline-cannot-alter-testicular-dysfunction-and-pineal-activation-caused-by-noise-in-wistar-rat
#16
Indraneel Saha, Aniruddha Chatterjee, Urmi Chatterji, B R Maiti
Millions of people consume betel nut for increased capacity to work and for stress reduction. The nut contains arecoline, which has multiple side effects on endocrine functions. Objective of the work is to investigate pineal-testicular responses to noise and after arecoline treatment in noise in rats. Noise exposure (100 dB, 6 h daily, 10 days) caused pineal stimulation ultrastructurally and at indoleamines level. Leydig cell dysfunction with fall of testosterone level and suppression of sex accessories were noticed...
July 13, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28678534/confirmatory-factor-analysis-and-structural-equation-modeling-of-socio-cultural-constructs-among-chamorro-and-non-chamorro-micronesian-betel-nut-chewers
#17
Kelle L Murphy, Min Liu, Thaddeus A Herzog
OBJECTIVES: Betel nut chewing is embedded within the cultures of South Asia, and Southeast Asia, and the Western Pacific. The determinants of betel nut consumption are complex. Ongoing consumption of betel nut is affected by cultural, social, and drug-specific effects (i.e. dependence). This study's first objective was to assess the psychometric properties (i.e. reliability and validity) of the socio-cultural constructs in a survey developed for betel nut chewers. The study's second objective was to investigate the influence of socio-cultural variables on betel nut chewing behaviors among Chamorro and non-Chamorro Micronesians in Guam...
July 5, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28653927/detection-of-interleukins-6-and-8-in-saliva-as-potential-biomarkers-of-oral-pre-malignant-lesion-and-oral-carcinoma-a-breakthrough-in-salivary-diagnostics-in-pakistan
#18
Iqbal A Muhammad Khyani, Masood A Qureshi, Talat Mirza, M Umar Farooq
Oral cancer is at rise in our population due to increasing use of areca nut (Betel nut) with or without tobacco. It is the second frequent malignant tumour for both the gender in Pakistan. This non-interventional case control study was carried out with the aim to explore saliva as diagnostic medium for detecting interleukins (IL) 6 and 8 as biomarkers of pre-malignant lesions (PML) and oral carcinoma. Total 105 subjects were recruited and were divided into three groups "A", "B" and "C" each comprising of 35 subjects...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28616897/alcohol-and-other-substance-use-among-a-sample-of-young-people-in-the-solomon-islands
#19
Brendan Quinn, Elizabeth Peach, Cassandra J C Wright, Megan S C Lim, Lisa Davidson, Paul Dietze
OBJECTIVE: Investigate alcohol and other substance use, with a focus on harmful alcohol use patterns, among young people in the Solomon Islands. METHODS: A structured, interviewer-administered questionnaire was administered to respondents aged 15-24 years across four of the country's provinces in late 2015. RESULTS: Four hundred young people completed the questionnaire across urban, peri-urban and rural communities. The most common substances ever used by participants were betel nut (94%), licit/store-bought and/or illicit alcohol (79%) and tobacco (76%)...
June 14, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/28608829/providing-a-clean-environment-for-adolescents-evaluation-of-the-tobacco-hazards-prevention-act-in-taiwan
#20
Min-Li Chen, Li-Na Chou, Ya-Cheng Zheng
Cigarette smoking not only damages the health of adolescents, but also contributes to air pollution. The Tobacco Hazards Prevention Act in Taiwan stipulates that cigarettes should not be sold to persons younger than 18 years. Therefore, schools should actively educate students and raise awareness of the Tobacco Hazards Prevention Act to reduce the level of damage to the health of adolescents and maintain good air quality. This study had two main goals: (1) to evaluate the stipulation that no person shall provide tobacco products to persons under the age of 18 and the effects of counseling strategies on store managers confirming customer ages before tobacco sale in southern Taiwan; and (2) to evaluate the situation of tobacco hazard prevention education conducted by school in southern Taiwan...
June 13, 2017: International Journal of Environmental Research and Public Health
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