Sobuj Mia, Mariame S Kane, Mary N Latimer, Cristine J Reitz, Ravi Sonkar, Gloria A Benavides, Samuel R Smith, Stuart J Frank, Tami A Martino, Jianhua Zhang, Victor M Darley-Usmar, Martin E Young
Cell-autonomous circadian clocks have emerged as temporal orchestrators of numerous biological processes. For example, the cardiomyocyte circadian clock modulates transcription, translation, posttranslational modifications, ion homeostasis, signaling cascades, metabolism, and contractility of the heart over the course of the day. Circadian clocks are composed of more than 10 interconnected transcriptional modulators, all of which have the potential to influence the cardiac transcriptome (and ultimately cardiac processes)...
June 1, 2020: American Journal of Physiology. Heart and Circulatory Physiology