keyword
https://read.qxmd.com/read/37709448/an-epoxide-based-covalent-sensor-to-detect-cardiac-proteome-aggregation-in-a-cardio-oncology-model
#1
JOURNAL ARTICLE
Hao Jin, Di Shen, Biao Jing, Zhenduo Zhang, Zhiming Wang, Rui Sun, Huaiyue Zhang, Jialu Sun, Haochen Lyu, Yu Liu, Lili Wang
Covalent sensors to detect and capture aggregated proteome in stressed cells are rare. Herein, we construct a series of covalent fluorogenic sensors for aggregated proteins by structurally modulating GFP chromophore and arming it with an epoxide warhead. Among them, P2 probe selectively modifies aggregated proteins over folded ones and turns on fluorescence as evidenced by biochemical and mass spectrometry results. The coverage of this epoxide-based covalent chemistry is demonstrated using different types of aggregated proteins...
October 16, 2023: Analytica Chimica Acta
https://read.qxmd.com/read/37373035/lncrnas-and-circrnas-in-endoplasmic-reticulum-stress-a-promising-target-for-cardiovascular-disease
#2
REVIEW
Francisco José Martinez-Amaro, Carlos Garcia-Padilla, Diego Franco, Houria Daimi
The endoplasmic reticulum (ER) is a principal subcellular organelle responsible for protein quality control in the secretory pathway, preventing protein misfolding and aggregation. Failure of protein quality control in the ER triggers several molecular mechanisms such as ER-associated degradation (ERAD), the unfolded protein response (UPR) or reticulophagy, which are activated upon ER stress (ERS) to re-establish protein homeostasis by transcriptionally and translationally regulated complex signalling pathways...
June 8, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37264620/over-expression-of-microrna-145-elevating-autophagy-activities-via-downregulating-frs2-expression
#3
JOURNAL ARTICLE
Tian Ke, Deng Bin, Han Xiaodong, Zheng Haiyi, Lin Tao, Zhimeng Wang, Zhang Yuanmin, Wang Guodong
OBJECTIVES: Osteoarthritis (OA) is one of the most common chronic and progressive joint diseases characterized by cartilage degeneration and chondrocyte death. In this study, we aimed to identify the modulation effect of miR-145 on chondrocytes' autophagy during the development of OA. BACKGROUND: Osteoarthritis (OA) is one of the most prevalent types of chronic and progressive joint disorder with the symptoms of joint pain and stiffness, and it leads to disability at the end stage...
June 2, 2023: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/37199573/covid-19-and-cardiovascular-diseases-from-cellular-mechanisms-to-clinical-manifestations
#4
REVIEW
Hongyang Shu, Zheng Wen, Na Li, Zixuan Zhang, Bala Musa Ceesay, Yizhong Peng, Ning Zhou, Dao Wen Wang
Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), quickly spread worldwide and led to over 581 million confirmed cases and over 6 million deaths as 1 August 2022. The binding of the viral surface spike protein to the human angiotensin-converting enzyme 2 (ACE2) receptor is the primary mechanism of SARS-CoV-2 infection. Not only highly expressed in the lung, ACE2 is also widely distributed in the heart, mainly in cardiomyocytes and pericytes. The strong association between COVID-19 and cardiovascular disease (CVD) has been demonstrated by increased clinical evidence...
March 16, 2023: Aging and Disease
https://read.qxmd.com/read/36778270/molecular-and-cellular-mechanisms-by-which-cardiac-sympathetic-denervation-prevents-heart-failure-and-sudden-cardiac-arrest
#5
Deeptankar DeMazumder, Pooja Joshi, Brian O'Rourke, Shanea Estes, Swati Dey
RATIONALE: Sudden cardiac arrest ( SCA ) and heart failure ( HF ) are leading causes of death. The underlying mechanisms are incompletely understood, limiting the design of effective therapies. Whereas most autonomic modulation therapies have failed to show benefit in HF patients, a growing body of clinical evidence over the past 50 years suggests cardiac sympathetic denervation ( CSD ) confers cardioprotection. However, the underlying molecular and cellular mechanisms remain unexplored...
January 31, 2023: bioRxiv
https://read.qxmd.com/read/36215693/bnip3l-nix-regulates-both-mitophagy-and-pexophagy
#6
JOURNAL ARTICLE
Léa P Wilhelm, Juan Zapata-Muñoz, Beatriz Villarejo-Zori, Stephanie Pellegrin, Catarina Martins Freire, Ashley M Toye, Patricia Boya, Ian G Ganley
Mitochondria and peroxisomes are closely related metabolic organelles, both in terms of origin and in terms of function. Mitochondria and peroxisomes can also be turned over by autophagy, in processes termed mitophagy and pexophagy, respectively. However, despite their close relationship, it is not known if both organelles are turned over under similar conditions, and if so, how this might be coordinated molecularly. Here, we find that multiple selective autophagy pathways are activated upon iron chelation and show that mitophagy and pexophagy occur in a BNIP3L/NIX-dependent manner...
October 10, 2022: EMBO Journal
https://read.qxmd.com/read/35935870/uncovering-the-effect-and-mechanism-of-rhizoma-corydalis-on-myocardial-infarction-through-an-integrated-network-pharmacology-approach-and-experimental-verification
#7
JOURNAL ARTICLE
Jingyan Li, Junxuan Wu, Junying Huang, Yuanyuan Cheng, Dawei Wang, Zhongqiu Liu
Background: Myocardial infarction (MI), characterized by reduced blood flow to the heart, is a coronary artery disorder with the highest morbidity and mortality among cardiovascular diseases. Consequently, there is an urgent need to identify effective drugs to treat MI. Rhizoma Corydalis (RC) is the dry tuber of Corydalis yanhusuo W.T. Wang, and is extensively applied in treating MI clinically in China. Its underlying pharmacological mechanism remains unknown. This study aims to clarify the molecular mechanism of RC on MI by utilizing network pharmacology and experimental verification...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35838212/a-review-of-current-evidence-from-cardiovascular-manifestations-and-outcomes-in-patients-with-covid-19
#8
JOURNAL ARTICLE
Shirin Saberianpour, Elahe Aleebrahim-Dehkordi, Elaheh Mazaheri, Ali Hasanpour-Dehkordi
BACKGROUND: In 2019, acute respiratory syndrome related to COVID-19 occurred as a global epidemic problem. The COVID-19 pathogenesis method is by using enzyme 2-converting enzyme angiotensin ACE2, which infects host cells, which is resulted in some organs, involving the lungs, heart, kidneys and intestines According to reports from the first signs of involvement of the cardiovascular system in various forms, the involvement of Cardiovascular injuries. The aim of this study was to evaluate the cardiovascular manifestations in COVID-19 disease...
July 13, 2022: Current Pharmaceutical Design
https://read.qxmd.com/read/35512484/phenotypic-screen-identifies-foxo-inhibitor-to-counteract-maturation-and-promote-expansion-of-human-ips-cell-derived-cardiomyocytes
#9
JOURNAL ARTICLE
Dennis Schade, Lauren Drowley, Qing-Dong Wang, Alleyn T Plowright, Boris Greber
Achieving pharmacological control over cardiomyocyte proliferation represents a prime goal in therapeutic cardiovascular research. Here, we identify a novel chemical tool compound for the expansion of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes. The forkhead box O (FOXO) inhibitor AS1842856 was identified as a significant hit from an unbiased proliferation screen in early, immature hiPSC- cardiomyocytes (eCMs). The mitogenic effects of AS1842856 turned out to be robust, dose-dependent, sustained, and reversible...
July 1, 2022: Bioorganic & Medicinal Chemistry
https://read.qxmd.com/read/35460665/pcsk9-inhibition-protects-against-myocardial-ischemia-reperfusion-injury-via-suppressing-autophagy
#10
JOURNAL ARTICLE
Guangwei Huang, Xiyang Lu, Haiyan Zhou, Runhong Li, Qing Huang, Xinlin Xiong, Zhenhua Luo, Wei Li
OBJECTIVES: Autophagy is critical for myocardial ischemia-reperfusion (I/R) injury. However, there is still considerable debate over its protective and deleterious effects. The purpose of this study was to determine the involvement of the proprotein convertase subtilisin/Kexin type 9 (PCSK9) and its inhibitor in myocardial ischemia-reperfusion injury autophagy (MRI). METHODS: Nine groups of eighty rats were used: sham, I/R2 h, I/R4 h, I/R6 h, I/R8 h, I/R1 d, and I/R2 d...
July 2022: Microvascular Research
https://read.qxmd.com/read/34628401/-clinical-efficacy-of-a-representative-of-a-new-class-of-inotropic-agents-the-direct-activator-of-myosin-of-cardiomyocytes-omecamtiv-mecarbil-in-heart-failure-with-a-reduced-ejection-fraction
#11
JOURNAL ARTICLE
I Kravchenko, Iu Rudyk, O Medentseva
Over the past decades, there has been an active scientific search for drugs that can increase myocardial contractility and improve the course of heart failure. Omecamtiv Mecarbil, a drug from the group of cardiac myosin activators, heads the list of applicants for clinical use. The article presents the results of several randomized clinical trials which studied the efficacy and safety of Omecamtiv Mecarbil in heart failure: ATOMIC-AHF, COSMIC-HF and GALACTIC-HF. ATOMIC-AHF showed a tendency to reduce the risk of developing supraventricular and ventricular arrhythmias in heart failure...
September 2021: Georgian Medical News
https://read.qxmd.com/read/34201562/physical-exercise-and-cardiac-repair-the-potential-role-of-nitric-oxide-in-boosting-stem-cell-regenerative-biology
#12
REVIEW
Fabiola Marino, Mariangela Scalise, Eleonora Cianflone, Luca Salerno, Donato Cappetta, Nadia Salerno, Antonella De Angelis, Daniele Torella, Konrad Urbanek
Over the years strong evidence has been accumulated showing that aerobic physical exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk. Exercise in healthy subjects fosters physiological remodeling of the adult heart. Concurrently, physical training can significantly slow-down or even reverse the maladaptive pathologic cardiac remodeling in cardiac diseases, improving heart function. The underlying cellular and molecular mechanisms of the beneficial effects of physical exercise on the heart are still a subject of intensive study...
June 23, 2021: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/34164652/hooked-on-heart-regeneration-the-zebrafish-guide-to-recovery
#13
JOURNAL ARTICLE
Katherine M Ross Stewart, Sophie L Walker, Andrew H Baker, Paul R Riley, Mairi Brittan
While humans lack sufficient capacity to undergo cardiac regeneration following injury, zebrafish can fully recover from a range of cardiac insults. Over the past two decades our understanding of the complexities of both the independent and co-ordinated injury responses by multiple cardiac tissues during zebrafish heart regeneration has increased exponentially. Although cardiomyocyte regeneration forms the cornerstone of the reparative process in the injured zebrafish heart, recent studies have shown that this is dependent on prior neovascularisation and lymphangiogenesis, which in turn require epicardial, endocardial and inflammatory cell signalling within an extracellular milieu that is optimised for regeneration...
June 23, 2021: Cardiovascular Research
https://read.qxmd.com/read/32948607/autophagy-inhibition-enables-nrf2-to-exaggerate-the-progression-of-diabetic-cardiomyopathy-in-mice
#14
JOURNAL ARTICLE
Huimei Zang, Weiwei Wu, Lei Qi, Wenbin Tan, Prakash Nagarkatti, Mitzi Nagarkatti, Xuejun Wang, Taixing Cui
Nuclear factor-erythroid factor 2-related factor 2 (Nrf2) may either ameliorate or worsen diabetic cardiomyopathy. However, the underlying mechanisms are poorly understood. Herein we report a novel mechanism of Nrf2-mediated myocardial damage in type 1 diabetes (T1D). Global Nrf2 knockout (Nrf2KO) hardly affected the onset of cardiac dysfunction induced by T1D but slowed down its progression in mice independent of sex. In addition, Nrf2KO inhibited cardiac pathological remodeling, apoptosis and oxidative stress associated with both onset and advancement of cardiac dysfunction in T1D...
September 18, 2020: Diabetes
https://read.qxmd.com/read/32635662/effects-of-lipids-and-lipoproteins-on-mesenchymal-stem-cells-used-in-cardiac-tissue-regeneration
#15
REVIEW
Yi-Hsiung Lin, Lin Kang, Wen-Han Feng, Tsung-Lin Cheng, Wei-Chung Tsai, Hsuan-Ti Huang, Hsiang-Chun Lee, Chung-Hwan Chen
Mesenchymal stem cells (MSCs) have two characteristics of interest for this paper: the ability to self-renew, and the potential for multiple-lineage differentiation into various cells. MSCs have been used in cardiac tissue regeneration for over a decade. Adult cardiac tissue regeneration ability is quite low; it cannot repair itself after injury, as the heart cells are replaced by fibroblasts and lose function. It is therefore important to search for a feasible way to repair and restore heart function through stem cell therapy...
July 5, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32575374/modeling-cardiac-disease-mechanisms-using-induced-pluripotent-stem-cell-derived-cardiomyocytes-progress-promises-and-challenges
#16
REVIEW
Elvira Immacolata Parrotta, Valeria Lucchino, Luana Scaramuzzino, Stefania Scalise, Giovanni Cuda
Cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood vessels. Despite progress in clinical research and therapy, CVDs still represent the leading cause of mortality and morbidity worldwide. The hallmarks of cardiac diseases include heart dysfunction and cardiomyocyte death, inflammation, fibrosis, scar tissue, hyperplasia, hypertrophy, and abnormal ventricular remodeling. The loss of cardiomyocytes is an irreversible process that leads to fibrosis and scar formation, which, in turn, induce heart failure with progressive and dramatic consequences...
June 19, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32374254/clinical-based-cell-therapies-for-heart-disease-current-and-future-state
#17
REVIEW
Darren Turner, Angela C Rieger, Wayne Balkan, Joshua M Hare
Patients have an ongoing unmet need for effective therapies that reverse the cellular and functional damage associated with heart damage and disease. The discovery that ~1%-2% of adult cardiomyocytes turn over per year provided the impetus for treatments that stimulate endogenous repair mechanisms that augment this rate. Preclinical and clinical studies provide evidence that cell-based therapy meets these therapeutic criteria. Recent and ongoing studies are focused on determining which cell type(s) works best for specific patient population(s) and the mechanism(s) by which these cells promote repair...
April 29, 2020: Rambam Maimonides Medical Journal
https://read.qxmd.com/read/32357113/differential-effects-of-rev-erb%C3%AE-%C3%AE-agonism-on-cardiac-gene-expression-metabolism-and-contractile-function-in-a-mouse-model-of-circadian-disruption
#18
JOURNAL ARTICLE
Sobuj Mia, Mariame S Kane, Mary N Latimer, Cristine J Reitz, Ravi Sonkar, Gloria A Benavides, Samuel R Smith, Stuart J Frank, Tami A Martino, Jianhua Zhang, Victor M Darley-Usmar, Martin E Young
Cell-autonomous circadian clocks have emerged as temporal orchestrators of numerous biological processes. For example, the cardiomyocyte circadian clock modulates transcription, translation, posttranslational modifications, ion homeostasis, signaling cascades, metabolism, and contractility of the heart over the course of the day. Circadian clocks are composed of more than 10 interconnected transcriptional modulators, all of which have the potential to influence the cardiac transcriptome (and ultimately cardiac processes)...
June 1, 2020: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/32188566/cardiomyocyte-calcium-handling-in-health-and-disease-insights-from-in-vitro-and-in-silico-studies
#19
JOURNAL ARTICLE
Henry Sutanto, Aurore Lyon, Joost Lumens, Ulrich Schotten, Dobromir Dobrev, Jordi Heijman
Calcium (Ca2+ ) plays a central role in cardiomyocyte excitation-contraction coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca2+ levels are regulated by a variety of Ca2+ -handling proteins. In turn, Ca2+ modulates numerous electrophysiological processes. Accordingly, Ca2+ -handling abnormalities can promote cardiac arrhythmias via various mechanisms, including the promotion of afterdepolarizations, ion-channel modulation and structural remodeling. In the last 30 years, significant improvements have been made in the computational modeling of cardiomyocyte Ca2+ handling under physiological and pathological conditions...
March 15, 2020: Progress in Biophysics and Molecular Biology
https://read.qxmd.com/read/31742355/nitric-oxide-modulates-cardiomyocyte-ph-control-through-a-biphasic-effect-on-sodium-hydrogen-exchanger-1
#20
JOURNAL ARTICLE
Mark A Richards, Jillian N Simon, Ruichong Ma, Aminah A Loonat, Mark J Crabtree, David J Paterson, Richard P Fahlman, Barbara Casadei, Larry Fliegel, Pawel Swietach
AIMS: When activated, Na+/H+ exchanger-1 (NHE1) produces some of the largest ionic fluxes in the heart. NHE1-dependent H+ extrusion and Na+ entry strongly modulate cardiac physiology through the direct effects of pH on proteins and by influencing intracellular Ca2+ handling. To attain an appropriate level of activation, cardiac NHE1 must respond to myocyte-derived cues. Among physiologically important cues is nitric oxide (NO), which regulates a myriad of cardiac functions, but its actions on NHE1 are unclear...
October 1, 2020: Cardiovascular Research
keyword
keyword
34303
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.