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Cynthia A Stuenkel, JoAnn E Manson
No abstract text is available yet for this article.
October 9, 2017: JAMA Internal Medicine
Deirdre K Tobias, Jennifer J Stuart, Shanshan Li, Jorge Chavarro, Eric B Rimm, Janet Rich-Edwards, Frank B Hu, JoAnn E Manson, Cuilin Zhang
Importance: Previous studies identify gestational diabetes (GD) as a risk factor for intermediate markers of cardiovascular disease (CVD) risk; however, few are prospective, evaluate hard CVD end points, or account for shared risk factors including body weight and lifestyle. Objective: To prospectively evaluate history of GD in relation to incident CVD risk. Design, Setting, and Participants: The Nurses' Health Study II (NHS II) is an observational cohort study of US female nurses established in 1989, with ongoing follow-up...
October 16, 2017: JAMA Internal Medicine
Xiaochen Lin, Charles B Eaton, JoAnn E Manson, Simin Liu
PURPOSE OF REVIEW: Physical activity (PA) is a well-established modifiable lifestyle determinant for multiple cardio-metabolic outcomes. While many psychosocial and environmental correlates of PA have been identified, current understanding of the genetic architecture that contributes to PA is still very limited, especially when compared to other phenotypes such as obesity and diabetes. RECENT FINDINGS: This review systematically and comprehensively assesses available evidence from animal experiments, family studies, population-based candidate gene analyses, and genome-wide association studies (GWAS) studying the genetics of physical activity patterns...
October 18, 2017: Current Cardiology Reports
Abigail L Manson, Thomas Abeel, James Galagan, Jagadish Chandrabose Sundaramurthi, Siva Kumar Shanmugam, Kannan Palaniyandi, Sujatha Narayanan, Soumya Swaminathan, Ashlee M Earl
No abstract text is available yet for this article.
October 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
JoAnn V Pinkerton, Andrew M Kaunitz, JoAnn E Manson
No abstract text is available yet for this article.
October 16, 2017: Menopause: the Journal of the North American Menopause Society
P Y Iroh Tam, B Krzyzanowski, J M Oakes, L Kne, S Manson
Fine resolution spatial variability in pneumonia hospitalization may identify correlates with socioeconomic, demographic and environmental factors. We performed a retrospective study within the Fairview Health System network of Minnesota. Patients 2 months of age and older hospitalized with pneumonia between 2011 and 2015 were geocoded to their census block group, and pneumonia hospitalization risk was analyzed in relation to socioeconomic, demographic and environmental factors. Spatial analyses were performed using Esri's ArcGIS software, and multivariate Poisson regression was used...
October 17, 2017: Epidemiology and Infection
Stephanie A Bien, James S Pankow, Jeffrey Haessler, Yinchang Lu, Nathan Pankratz, Rebecca R Rohde, Alfred Tamuno, Christopher S Carlson, Fredrick R Schumacher, Petra Bůžková, Martha L Daviglus, Unhee Lim, Myriam Fornage, Lindsay Fernandez-Rhodes, Larissa Avilés-Santa, Steven Buyske, Myron D Gross, Mariaelisa Graff, Carmen R Isasi, Lewis H Kuller, JoAnn E Manson, Tara C Matise, Ross L Prentice, Lynne R Wilkens, Sachiko Yoneyama, Ruth J F Loos, Lucia A Hindorff, Loic Le Marchand, Kari E North, Christopher A Haiman, Ulrike Peters, Charles Kooperberg
The authors regret that Yinchang Lu's name incorrectly included a middle initial in the author list. The details given in this erratum are correct.
October 16, 2017: Diabetologia
Sasikiran Pasupuleti, Nitesh Sule, Michael D Manson, Arul Jayaraman
The detection of norepinephrine (NE) as a chemoattractant by E. coli K-12 requires the combined action of the TynA monoamine oxidase and the FeaB aromatic aldehyde dehydrogenase. These role is to convert NE into 3,4-dihydroxymandelic acid (DHMA), which is a potent chemoattractant sensed by the Tsr chemoreceptor. These two enzymes must be induced by prior exposure to NE, and cells that exposed to NE for the first time initially show minimal chemotaxis toward it. The induction of TynA and FeaB requires the QseC quorum-sensing histidine kinase, and the signaling cascade requires new protein synthesis...
October 16, 2017: Journal of Bacteriology
James Alibhai, Abigail Diack, Jean Manson
Chronic neurodegenerative diseases, such as prion diseases or Alzheimer's disease, are associated with progressive accumulation of host proteins which misfold and aggregate. Neurodegeneration is restricted to specific neuronal populations which show clear accumulation of misfolded proteins, whilst neighbouring neurons remain unaffected. Such data raise interesting questions about the vulnerability of specific neuronal populations to neurodegeneration and much research has concentrated only on the mechanisms of neurodegeneration in afflicted neuronal populations...
October 12, 2017: Prion
Brian W Whitcomb, Alexandra C Purdue-Smithe, Kathleen L Szegda, Maegan E Boutot, Susan E Hankinson, JoAnn E Manson, Bernard Rosner, Walter C Willett, A Heather Eliassen, Elizabeth R Bertone-Johnson
Menopause before age 45 affects roughly 5%-10% of women and is associated with higher risk of adverse health conditions. Smoking may increase early menopause risk; however, evidence is inconsistent, and data regarding smoking amount, duration, cessation and patterns over time and risk are scant. We used data from the Nurses' Health Study II of 116,429 nurses from 1989 through 2011 and Cox proportional hazards models to estimate hazard ratios (HR) adjusting for confounders. Compared to never-smokers, current smokers had a HR of 1...
August 10, 2017: American Journal of Epidemiology
S C Charrot, R S Sellar, J J Manson
No abstract text is available yet for this article.
October 2, 2017: British Journal of Hospital Medicine
C Stavrou, C Wincup, G Kravvas, J Manson
No abstract text is available yet for this article.
October 2, 2017: British Journal of Hospital Medicine
Todd C Monson, Tyler E Stevens, Jean L Leger, Jamie L Manson, Katherine S Lovejoy, Aimee L Newsham, Rico E Del Sesto
Ionic liquids containing lanthanide halide anions give the opportunity to investigate magnetic behaviour in non-ordered systems. Reported herein is the synthesis and characterization of ionic liquids containing a series of lanthanide halide anions, with the resulting materials displaying unusual behaviour below 50 K. Specifically, the ionic liquid structural glass formation appears to drive magnetic behaviour due to cluster formation of the anions during rapid cooling. This system presents a possible probe to study the dynamics of glass forming materials...
October 11, 2017: Chemical Communications: Chem Comm
Lynne de Welzen, Vegard Eldholm, Kashmeel Maharaj, Abigail L Manson, Ashlee M Earl, Alexander S Pym
Genetic based drug susceptibility testing has improved the diagnosis of drug-resistant tuberculosis, but is limited by our lack of knowledge of all resistance mechanisms. Next generation sequencing has assisted in identifying the principal genetic mechanisms of resistance for many drugs, but a significant proportion of phenotypic drug resistance is unexplained genetically. Few studies have formally compared the transcriptome of susceptible and resistant M. tuberculosis We carried out comparative whole genome transcriptomics on extensively drug-resistant (XDR) clinical isolates using RNA-sequencing (RNAseq) to find novel transcriptional mediated mechanisms of resistance...
October 9, 2017: Antimicrobial Agents and Chemotherapy
Maegan E Boutot, Alexandra Purdue-Smithe, Brian W Whitcomb, Kathleen L Szegda, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Elizabeth R Bertone-Johnson
Early menopause, the cessation of ovarian function prior to age 45, affects 5-10% of Western women and is associated with an increased risk of adverse health outcomes. Literature suggests that high vegetable protein intake may prolong female reproductive function. We evaluated the relation of long-term intake of vegetable protein, animal protein, and specific protein-rich foods with incidence of early natural menopause in the Nurses' Health Study II cohort. Women included in analyses (n = 85,682) were premenopausal at baseline (1991) and followed until 2011 for onset of natural menopause...
June 24, 2017: American Journal of Epidemiology
Baoming Gong, Shaohua Cui, Yun Zhao, Yongtao Sun, Qian Ding
In the study, the low-cycle fatigue behaviors of 3D-printed poly lactic acid (PLA) scaffolds with 60% porosity and two kinds of geometrical pores were investigated under strain-controlled loading. The obtained Δεa-Nf curves were fitted by Coffin-Manson relation. The mechanical stability of the porous structure under cyclic loading was studied. Both kinds of specimens undergo the strain softening after the initial cyclic hardening. The scaffold with circular pore exhibits stable resistance to the fatigue damage which is desirable for bone repairing...
October 12, 2017: Journal of Biomaterials Science. Polymer Edition
Adela Hruby, Marta Guasch-Ferré, Shilpa N Bhupathiraju, JoAnn E Manson, Walter C Willett, Nicola M McKeown, Frank B Hu
OBJECTIVE: Magnesium intake is inversely associated with risk of type 2 diabetes in many observational studies, but few have assessed this association in the context of the carbohydrate quality of the diet. We hypothesized that higher magnesium intake is associated with lower risk of type 2 diabetes, especially in the context of a poor-carbohydrate-quality diet characterized by low cereal fiber or high glycemic index (GI) or glycemic load (GL). RESEARCH DESIGN AND METHODS: In the Nurses' Health Study (NHS; 1984-2012, n = 69,176), NHS2 (1991-2013, n = 91,471), and the Health Professionals' Follow-Up Study (1986-2012, n = 42,096), dietary intake was assessed from food frequency questionnaires every 4 years...
October 4, 2017: Diabetes Care
Xiaoyan Leng, Mark A Espeland, JoAnn E Manson, Marcia L Stefanick, Emily W Gower, Kathleen M Hayden, Marian C Limacher, Leslie Vaughan, Jennifer Robinson, Robert Wallace, Sylvia Wassertheil-Smoller, Kristine Yaffe, Sally A Shumaker
Background: Cognitive impairment and decline may signal the increased risk of incident cardiovascular disease (CVD). We examined associations of global cognitive function, as measured by the Modified Mini-Mental State Examination (3MS) and changes in 3MS over time, with incident CVD, individual CVD outcomes, CVD death, and all-cause mortality. Methods: A total of 5,596 women (≥ 60) from the Women's Health Initiative Memory Study free of CVD at baseline were followed for an average of 7...
July 25, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Sarah J O Nomura, Chiranjeev Dash, Vanessa B Sheppard, Deborah Bowen, Matthew Allison, Wendy Barrington, Rowan Chlebowski, Mace Coday, Lifang Hou, Barbara Howard, Michael LaMonte, JoAnn E Manson, Marian L Neuhouser, Electra Paskett, Maryam Sattari, Marcia Stefanick, Jean Wactawski-Wende, Lucile L Adams-Campbell
PURPOSE: The objective of this study was to evaluate the prospective association between sedentary time and postmenopausal breast cancer incidence, and whether associations differ by race/ethnicity, physical activity levels, and body measurements. METHODS: The Women's Health Initiative Observational Study is a prospective cohort among women ages 50-79 years at baseline (1994-1998) (analytic cohort = 70,233). Baseline questionnaire data were used to estimate time spent sitting and total sedentary time...
October 3, 2017: Cancer Causes & Control: CCC
Alan Fenwick
On 14 December 2016, Professor Alan Fenwick OBE delivered the prestigious 'Manson Lecture' to the Royal Society for Tropical Medicine and Hygiene at the Royal Society in London. This paper, based on the Manson Lecture, presents the research carried out to study the epidemiology of schistosomiasis in Africa and test the various control tools as they were proposed from 1914 to date. Subsequently the development of national control programmes against schistosomiasis in Africa from 2000 towards the full national coverage now being delivered in many countries is discussed...
May 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
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