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https://www.readbyqxmd.com/read/28731405/pro-death-nmda-receptor-signaling-is-promoted-by-the-glun2b-c-terminus-independently-of-dapk1
#1
Jamie McQueen, Tomas J Ryan, Sean McKay, Katie Fm Marwick, Paul E Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David Ja Wyllie, Seth Gn Grant, Barry McColl, Noboru Komiyama, Giles E Hardingham
Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it potentiates excitotoxic signaling. The key GluN2B CTD-centred event in excitotoxicity is proposed to involve its phosphorylation at Ser-1303 by DAPK1, that is blocked by a neuroprotective cell-permeable peptide mimetic of the region. Contrary to this model, we find that excitotoxicity can proceed without increased Ser-1303 phosphorylation, and is unaffected by DAPK1 deficiency in vitro or following ischemia in vivo...
July 21, 2017: ELife
https://www.readbyqxmd.com/read/28730301/biopsychosocial-factors-predict-quality-of-life-in-thoracolumbar-spine-surgery
#2
Dean A Tripp, Edward Abraham, Maude Lambert, Kate Wagg, Erin Bigney, Eden Daly, Phylicia Verreault, Neil Manson
PURPOSE: Surgical intervention is a treatment option for various spinal pathology but many patients report no improvement or even an exacerbation of symptoms like pain. This study examined the association of preoperative (pre-op) biopsychosocial risk factors with poor quality of life at 2 and 6 months using hierarchical models controlling demographic and medical variables. METHOD: Participants undergoing thoracolumbar spine surgery (N = 214) were provided with questionnaire packages to complete pre-op, at 2 and at 6-month postoperative clinical follow-ups (i...
July 20, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28728684/healthful-and-unhealthful-plant-based-diets-and-the-risk-of-coronary-heart%C3%A2-disease-in-u-s-adults
#3
Ambika Satija, Shilpa N Bhupathiraju, Donna Spiegelman, Stephanie E Chiuve, JoAnn E Manson, Walter Willett, Kathryn M Rexrode, Eric B Rimm, Frank B Hu
BACKGROUND: Plant-based diets are recommended for coronary heart disease (CHD) prevention. However, not all plant foods are necessarily beneficial for health. OBJECTIVES: This study sought to examine associations between plant-based diet indices and CHD incidence. METHODS: We included 73,710 women in NHS (Nurses' Health Study) (1984 to 2012), 92,329 women in NHS2 (1991 to 2013), and 43,259 men in Health Professionals Follow-up Study (1986 to 2012), free of chronic diseases at baseline...
July 25, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28727519/obesity-and-overweight-in-american-indian-and-alaska-native-children-2006-2015
#4
Ann Bullock, Karen Sheff, Kelly Moore, Spero Manson
OBJECTIVES: To estimate obesity and overweight prevalence in American Indian and Alaska Native (AI/AN) children across genders, ages, and geographic regions in the Indian Health Service active clinical population. METHODS: We obtained data from the Indian Health Service National Data Warehouse. At least 184 000 AI/AN children aged 2 to 19 years had body mass index data for each year studied, 2006 to 2015. We calculated body mass index percentiles with the 2000 Centers for Disease Control and Prevention growth charts...
July 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28723233/treatment-patterns-and-clinical-outcomes-with-pazopanib-in-patients-with-advanced-soft-tissue-sarcomas-in-a-compassionate-use-setting-results-of-the-spire-study
#5
Hans Gelderblom, Ian R Judson, Charlotte Benson, Ofer Merimsky, Giovanni Grignani, Daniela Katz, Klaus W Freivogel, Dara Stein, Minesh Jobanputra, Arron Mungul, Stephanie C Manson, Roberta Sanfilippo
BACKGROUND: A named patient program (NPP) was designed to provide patients with advanced soft-tissue sarcoma (aSTS) access to pazopanib, a multitargeted tyrosine kinase inhibitor. The SPIRE study was a retrospective chart review of participating patients. PATIENTS AND METHODS: Eligibility criteria for the NPP and SPIRE mirrored those of the pivotal phase-III study, PALETTE, which compared pazopanib with placebo in patients ≥18 years with aSTS and whose disease had progressed during or following prior chemotherapy or were otherwise unsuitable for chemotherapy...
July 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28719691/associations-of-weight-gain-from-early-to-middle-adulthood-with-major-health-outcomes-later-in-life
#6
Yan Zheng, JoAnn E Manson, Changzheng Yuan, Matthew H Liang, Francine Grodstein, Meir J Stampfer, Walter C Willett, Frank B Hu
Importance: Data describing the effects of weight gain across adulthood on overall health are important for weight control. Objective: To examine the association of weight gain from early to middle adulthood with health outcomes later in life. Design, Setting, and Participants: Cohort analysis of US women from the Nurses' Health Study (1976-June 30, 2012) and US men from the Health Professionals Follow-Up Study (1986-January 31, 2012) who recalled weight during early adulthood (at age of 18 years in women; 21 years in men), and reported current weight during middle adulthood (at age of 55 years)...
July 18, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28717028/the-norepinephrine-metabolite-3-4-dihydroxymandelic-acid-is-produced-by-the-commensal-microbiota-and-promotes-chemotaxis-and-virulence-gene-expression-in-enterohemorrhagic-escherichia-coli
#7
Nitesh Sule, Sasi Pasupuleti, Nandita Kohli, Rani Menon, Lawrence J Dangott, Michael D Manson, Arul Jayaraman
Enterohemorrhagic E. coli (EHEC) is a commonly occuring foodborne pathogen responsible for numerous multistate outbreaks in the US. It is known to infect the host gastrointestinal tract, specifically in locations associated with lymphoid tissue. These niches serve as sources of enteric neurotransmitters such as epinephrine and norepinephrine that are known to increase virulence in several pathogens, including enterohemorrhagic E. coli The mechanisms that allow pathogens to target these niches are poorly understood...
July 17, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28715416/signatures-of-inflammation-and-impending-multiple-organ-dysfunction-in-the-hyperacute-phase-of-trauma-a-prospective-cohort-study
#8
Claudia P Cabrera, Joanna Manson, Joanna M Shepherd, Hew D Torrance, David Watson, M Paula Longhi, Mimoza Hoti, Minal B Patel, Michael O'Dwyer, Sussan Nourshargh, Daniel J Pennington, Michael R Barnes, Karim Brohi
BACKGROUND: Severe trauma induces a widespread response of the immune system. This "genomic storm" can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome (MODS). MODS carries a high mortality and morbidity rate and adversely affects long-term health outcomes. Contemporary management of MODS is entirely supportive, and no specific therapeutics have been shown to be effective in reducing incidence or severity. The pathogenesis of MODS remains unclear, and several models are proposed, such as excessive inflammation, a second-hit insult, or an imbalance between pro- and anti-inflammatory pathways...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28701540/a-novel-paraplegia-model-in-awake-behaving-macaques
#9
Max Ostrinsky Krucoff, Katie Zhuang, David B Macleod, Allen Yin, Yoon Woo Byun, Roberto Jose Manson, Dennis A Turner, Laura Oliveira, Mikhail A Lebedev
Lower limb paralysis from spinal cord injury (SCI) or neurological disease carries a poor prognosis for recovery and remains a large societal burden. Neurophysiological and neuroprosthetic research have the potential to improve quality of life for these patients; however, the lack of an ethical and sustainable non-human primate model for paraplegia hinders their advancement. Therefore, our multi-disciplinary team developed a way to induce temporary paralysis in awake behaving macaques by creating a fully implantable lumbar epidural catheter-subcutaneous port system that enables easy and reliable targeted drug delivery for sensorimotor blockade...
July 12, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28701334/genetic-susceptibility-change-in-physical-activity-and-long-term-weight-gain
#10
Tiange Wang, Tao Huang, Yoriko Heianza, Dianjianyi Sun, Yan Zheng, Wenjie Ma, Majken K Jensen, Jae H Kang, Janey L Wiggs, Louis R Pasquale, Eric B Rimm, JoAnn E Manson, Frank B Hu, Walter C Willett, Lu Qi
Whether change in physical activity over time modifies the genetic susceptibility to long-term weight gain is unknown. We calculated a body mass index (BMI)-genetic risk score (GRS) based on 77 BMI-associated single-nucleotide polymorphisms (SNPs) and a body fat percentage (BF%)-GRS based on 12 BF%-associated SNPs, respectively, in 9,390 women from the Nurses' Health Study (NHS) and 5,291 men from the Health Professionals Follow-up Study (HPFS). We analyzed the interactions between each GRS and change in physical activity on BMI/body weight change within five 4-year intervals from 1986 to 2006 using multivariable generalized linear models with repeated-measures analyses...
July 12, 2017: Diabetes
https://www.readbyqxmd.com/read/28697246/posing-causal-questions-when-analyzing-observational-data
#11
Shilpa N Bhupathiraju, Meir J Stampfer, JoAnn E Manson
No abstract text is available yet for this article.
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28697036/comparison-of-clinical-outcomes-among-users-of-oral-and-transdermal-estrogen-therapy-in-the-women-s-health-initiative-observational-study
#12
Carolyn J Crandall, Kathleen M Hovey, Christopher Andrews, Jane A Cauley, Marcia Stefanick, Chrisandra Shufelt, Ross L Prentice, Andrew M Kaunitz, Charles Eaton, Jean Wactawski-Wende, JoAnn E Manson
OBJECTIVE: To examine associations of estrogen preparations with an index of health risks versus benefits. METHODS: Using data from 45,112 participants of the Women's Health Initiative Observational Study (average follow-up 5.5 years), we examined associations of estrogen type and oral conjugated equine estrogen (CEE) dose with time to first global index event (GIE), defined as coronary heart disease, breast cancer, stroke, pulmonary embolism, hip fracture, colorectal cancer, endometrial cancer, or death...
July 10, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28689316/higher-lipophilic-index-indicates-higher-risk-of-coronary-heart-disease-in-postmenopausal-women
#13
Qing Liu, Alice H Lichtenstein, Nirupa R Matthan, Chanelle J Howe, Matthew A Allison, Barbara V Howard, Lisa W Martin, Carolina Valdiviezo, JoAnn E Manson, Simin Liu, Charles B Eaton
Fatty acids (FAs) are essential components of cell membranes and play an integral role in membrane fluidity. The lipophilic index [LI, defined as the sum of the products between FA levels and melting points (°C), divided by the total amount of FA: [Formula: see text]] is thought to reflect membrane and lipoprotein fluidity and may be associated with the risk of coronary heart disease (CHD). Therefore, we examined the associations of dietary and plasma phospholipid (PL) LI with CHD risk among postmenopausal women...
July 8, 2017: Lipids
https://www.readbyqxmd.com/read/28686129/centres-for-leadership-a-strategy-for-academic-integration
#14
Gillian King, Kathryn Parker, Sean Peacocke, C J Curran, Amy C McPherson, Tom Chau, Elaine Widgett, Darcy Fehlings, Golda Milo-Manson
Purpose The purpose of this paper is to describe how an Academic Health Science Centre, providing pediatric rehabilitation services, research, and education, developed a Centres for Leadership (CfL) initiative to integrate its academic functions and embrace the goal of being a learning organization. Design/methodology/approach Historical documents, tracked output information, and staff members' insights were used to describe the ten-year evolution of the initiative, its benefits, and transformational learnings for the organization...
May 15, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28685652/the-ubiquitous-pharmacogenomics-consortium-making-effective-treatment-optimization-accessible-to-every-european-citizen
#15
Lisanne En Manson, Cathelijne H van der Wouden, Jesse J Swen, Henk-Jan Guchelaar
No abstract text is available yet for this article.
July 7, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28673370/preface-glasgow-encounters-with-tropical-diseases
#16
Francis E G Cox
The period 1875-1925 was remarkable in the history of parasitology mainly for the elucidation of the life cycles of parasites causing important parasitic diseases and the incrimination of vectors in their transmission. These discoveries were made by a small number of scientists working in the tropics a number of whom were Scots. Sir Patrick Manson, the discoverer of the mosquito transmission of filarial worms, was instrumental in directly or indirectly encouraging other Scots including Douglas Argyll-Robertson, David Blacklock, David Bruce, David Cunningham, Robert Leiper, William Leishman, George Low, Muriel Robertson and Ronald Ross, who all made significant discoveries across a wide spectrum of tropical diseases...
July 4, 2017: Parasitology
https://www.readbyqxmd.com/read/28663251/gut-microbiota-metabolites-and-risk-of-major-adverse-cardiovascular-disease-events-and-death-a-systematic-review-and-meta-analysis-of-prospective-studies
#17
REVIEW
Yoriko Heianza, Wenjie Ma, JoAnn E Manson, Kathryn M Rexrode, Lu Qi
BACKGROUND: Gut microbial metabolites have been implicated as novel risk factors for cardiovascular events and premature death. The strength and consistency of associations between blood concentrations of the gut microbial metabolites, trimethylamine-N-oxide (TMAO) and its precursors, with major adverse cardiovascular events (MACE) or death have not been comprehensively assessed. We quantified associations of blood concentrations of TMAO and its precursors with risks of MACE and mortality...
June 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28659294/artificially-sweetened-beverages-sugar-sweetened-beverages-plain-water-and-incident-diabetes-mellitus-in-postmenopausal-women-the-prospective-women-s-health-initiative-observational-study
#18
Mengna Huang, Abdullah Quddus, Lynda Stinson, James M Shikany, Barbara V Howard, Randa M Kutob, Bing Lu, JoAnn E Manson, Charles B Eaton
Background: Sugar-sweetened beverages (SSBs) have been associated with an increased risk of diabetes mellitus (DM), whereas the association with artificially sweetened beverages (ASBs) is unclear.Objective: We aimed to evaluate the associations of ASB and SSB consumption with the risk of developing DM and the potential benefit of replacing SSBs with ASBs or water.Design: The national Women's Health Initiative recruited a large prospective cohort of postmenopausal women between 1993 and 1998. ASB, SSB, and water consumption was measured by lifestyle questionnaires, and DM was self-reported...
June 28, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28654363/low-fat-dietary-pattern-and-breast-cancer-mortality-in-the-women-s-health-initiative-randomized-controlled-trial
#19
Rowan T Chlebowski, Aaron K Aragaki, Garnet L Anderson, Cynthia A Thomson, JoAnn E Manson, Michael S Simon, Barbara V Howard, Thomas E Rohan, Linda Snetselar, Dorothy Lane, Wendy Barrington, Mara Z Vitolins, Catherine Womack, Lihong Qi, Lifang Hou, Fridtjof Thomas, Ross L Prentice
Purpose Earlier Women's Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as a primary outcome-related analysis from a randomized prevention trial, we examined the long-term influence of this intervention on deaths as a result of and after breast cancer during 8.5 years (median) of dietary intervention and cumulatively for all breast cancers diagnosed during 16.1 years (median) of follow-up. Patients and Methods The trial randomly assigned 48,835 postmenopausal women with normal mammograms and without prior breast cancer from 1993 to 1998 at 40 US clinical centers to a dietary intervention with goals of a reduction of fat intake to 20% of energy and an increased intake of fruits, vegetables, and grains (40%; n = 19,541) or to a usual diet comparison (60%; n = 29,294)...
June 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28641369/markers-of-inflammation-and-incident-breast-cancer-risk-in-the-women-s-health-study
#20
Deirdre K Tobias, Akintunde O Akinkuolie, Paulette D Chandler, Patrick R Lawler, JoAnn E Manson, Julie E Buring, Paul M Ridker, Lu Wang, I-Min Lee, Samia Mora
Chronic inflammation may be a risk factor for breast cancer development and progression, yet which inflammatory biomarkers and pathways are relevant is unknown. The study included 27,071 Women's Health Study participants (mean, 54.5 years old) free of cancer and cardiovascular disease at enrollment (1992 to 1995) with baseline measures of four inflammatory biomarkers: high sensitivity C-reactive protein (hsCRP), fibrinogen, N-acetyl side-chains of acute phase proteins (GlycA), and soluble intercellular adhesion molecule-1 (sICAM-1)...
June 21, 2017: American Journal of Epidemiology
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