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https://www.readbyqxmd.com/read/27917515/associations-between-benign-cutaneous-nevi-and-risk-of-type-2-diabetes-mellitus-in-men-and-women-results-from-two-prospective-cohort-studies
#1
H Dai, Q Sun, C Zhang, X Zhang, W-Q Li, J E Manson, F B Hu, Y Song
AIM: To examine the association of cutaneous nevi with Type 2 diabetes risk. METHODS: We prospectivly examined the associations between nevus count and risk of Type 2 diabetes among 26 240 men (1988-2010) from the Health Professionals Follow-up Study and 67 050 women (1986-2010) from the Nurses' Health Study. Information on the numbers of cutaneous nevi on arms at baseline and incident cases of Type 2 diabetes was collected using validated questionnaires. RESULTS: During 1 879 287 person-years of follow-up, we documented 9040 incident cases of Type 2 diabetes...
December 5, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27914662/surgical-site-infection-in-tibial-plateau-fractures-with-ipsilateral-compartment-syndrome
#2
Andrew G Dubina, Ebrahim Paryavi, Theodore T Manson, Christopher Allmon, Robert V O'Toole
AIM: The aim of this study was to investigate the effects of compartment syndrome and timing of fasciotomy wound closure on surgical site infection (SSI) after surgical fixation of tibial plateau fractures. Our primary hypothesis was that SSI rate is increased for fractures with compartment syndrome versus those without, even accounting for confounders associated with infection. Our secondary hypothesis was that infection rates are unrelated to timing of fasciotomy closure or fixation...
October 18, 2016: Injury
https://www.readbyqxmd.com/read/27911769/reductive-carboxylation-is-a-major-metabolic-pathway-in-the-retinal-pigment-epithelium
#3
Jianhai Du, Aya Yanagida, Kaitlen Knight, Abbi L Engel, Anh Huan Vo, Connor Jankowski, Martin Sadilek, Van Thi Bao Tran, Megan A Manson, Aravind Ramakrishnan, James B Hurley, Jennifer R Chao
The retinal pigment epithelium (RPE) is a monolayer of pigmented cells that requires an active metabolism to maintain outer retinal homeostasis and compensate for oxidative stress. Using (13)C metabolic flux analysis in human RPE cells, we found that RPE has an exceptionally high capacity for reductive carboxylation, a metabolic pathway that has recently garnered significant interest because of its role in cancer cell survival. The capacity for reductive carboxylation in RPE exceeds that of all other cells tested, including retina, neural tissue, glial cells, and a cancer cell line...
December 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27910443/x-ray-intensity-and-source-size-characterizations-for-the-25-kv-upgraded-manson-source-at-sandia-national-laboratories
#4
G Loisel, P Lake, P Gard, G Dunham, L Nielsen-Weber, M Wu, E Norris
At Sandia National Laboratories, the x-ray generator Manson source model 5 was upgraded from 10 to 25 kV. The purpose of the upgrade is to drive higher characteristics photon energies with higher throughput. In this work we present characterization studies for the source size and the x-ray intensity when varying the source voltage for a series of K-, L-, and M-shell lines emitted from Al, Y, and Au elements composing the anode. We used a 2-pinhole camera to measure the source size and an energy dispersive detector to monitor the spectral content and intensity of the x-ray source...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27902713/association-of-n-linked-glycoprotein-acetyls-and-colorectal-cancer-incidence-and-mortality
#5
Paulette D Chandler, Akintunde O Akinkuolie, Deirdre K Tobias, Patrick R Lawler, Chungying Li, M Vinayaga Moorthy, Lu Wang, Daniel A Duprez, David R Jacobs, Robert J Glynn, James Otvos, Margery A Connelly, Wendy S Post, Paul M Ridker, JoAnn E Manson, Julie E Buring, I-Min Lee, Samia Mora
BACKGROUND: Acute phase proteins highlight the dynamic interaction between inflammation and oncogenesis. GlycA, a novel nuclear magnetic resonance (NMR) inflammatory marker that identifies primarily circulating N-acetyl glycan groups attached to acute phase proteins, may be a future CRC risk biomarker. METHODS: We examined the association between GlycA and incident CRC and mortality in two prospective cohorts (N = 34,320); Discovery cohort: 27,495 participants from Women's Health Study (WHS); Replication cohort: 6,784 participants from Multi-Ethnic Study of Atherosclerosis (MESA)...
2016: PloS One
https://www.readbyqxmd.com/read/27901290/early-life-trauma-post-traumatic-stress-disorder-and-allostatic-load-in-a-sample-of-american-indian-adults
#6
Zaneta Thayer, Celestina Barbosa-Leiker, Michael McDonell, Lonnie Nelson, Dedra Buchwald, Spero Manson
OBJECTIVES: Among American Indians, prior research has found associations between early life trauma and the development of post-traumatic stress disorder (PTSD) in adulthood. Given the physiological changes associated with PTSD, early life trauma could indirectly contribute to chronic disease risk. However, the impact of early life trauma on adult physical health in this population has not been previously investigated. METHODS: We evaluated associations among early life trauma, PTSD, and 13 physiological biomarkers that index cardiovascular, metabolic, neuroendocrine, anthropometric, and immune function in adulthood by conducting correlation and structural equation modeling path analyses (N = 197)...
November 30, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27898529/controversies-in-the-principles-for-management-of-orbital-fractures-in-the-pediatric-population
#7
Amir H Dorafshar, Edward H Davidson, Paul N Manson
No abstract text is available yet for this article.
November 28, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27884868/combined-associations-of-body-weight-and-lifestyle-factors-with-all-cause-and-cause-specific-mortality-in-men-and-women-prospective-cohort-study
#8
Nicola Veronese, Yanping Li, JoAnn E Manson, Walter C Willett, Luigi Fontana, Frank B Hu
OBJECTIVE:  To evaluate the combined associations of diet, physical activity, moderate alcohol consumption, and smoking with body weight on risk of all cause and cause specific mortality. DESIGN:  Longitudinal study with up to 32 years of follow-up. SETTING:  Nurses' Health Study (1980-2012) and Health Professionals Follow-up Study (1986-2012). PARTICIPANTS:  74 582 women from the Nurses' Health Study and 39 284 men from the Health Professionals Follow-up Study who were free from cardiovascular disease and cancer at baseline...
November 24, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27884765/efficacy-of-clarithromycin-naproxen-oseltamivir-combination-in-the-treatment-of-patients-hospitalized-for-influenza-a-h3n2-infection-an-open-label-randomized-controlled-phase-2b-3-trial
#9
Ivan Fn Hung, Kelvin Kw To, Jasper Fw Chan, Vincent Cc Cheng, Kevin Sh Liu, Anthony Tam, Tuen-Ching Chan, Anna Jinxia Zhang, Patrick Li, Tin-Lun Wong, Ricky Zhang, Michael Ks Cheung, William Leung, Johnson Yn Lau, Manson Fok, Honglin Chen, Kwok-Hung Chan, Kwok-Yung Yuen
BACKGROUND: Influenza causes excessive hospitalizations and deaths. Single agent treatment with oseltamivir in severe influenza might be insufficient. The study assessed the efficacy and safety of oseltamivir-clarithromycin-naproxen combination for treatment of serious influenza. METHODS: From February to April 2015, we conducted a prospective open-label randomized-controlled trial. Adult patients hospitalized for A(H3N2) influenza were randomly assigned to a 2-day combination of clarithromycin 500mg, naproxen 200mg and oseltamivir 75mg twice daily, followed by 3 days of oseltamivir; or oseltamivir 75mg twice daily without placebos for 5 days as control (1:1)...
November 21, 2016: Chest
https://www.readbyqxmd.com/read/27880767/distribution-of-misfolded-prion-protein-seeding-activity-alone-does-not-predict-regions-of-neurodegeneration
#10
James Alibhai, Richard A Blanco, Marcelo A Barria, Pedro Piccardo, Byron Caughey, V Hugh Perry, Tom C Freeman, Jean C Manson
Protein misfolding is common across many neurodegenerative diseases, with misfolded proteins acting as seeds for "prion-like" conversion of normally folded protein to abnormal conformations. A central hypothesis is that misfolded protein accumulation, spread, and distribution are restricted to specific neuronal populations of the central nervous system and thus predict regions of neurodegeneration. We examined this hypothesis using a highly sensitive assay system for detection of misfolded protein seeds in a murine model of prion disease...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27871882/schistosomal-derived-lysophosphatidylcholine-triggers-m2-polarization-of-macrophages-through-ppar%C3%AE-dependent-mechanisms
#11
Leonardo Santos Assunção, Kelly G Magalhães, Alan Brito Carneiro, Raphael Molinaro, Patrícia E Almeida, Georgia C Atella, Hugo C Castro-Faria-Neto, Patrícia T Bozza
Mansonic schistosomiasis is a disease caused by the trematode Schistosoma mansoni, endemic to tropical countries. S. mansoni infection induces the formation of granulomas and potent polarization of Th2-type immune response. There is great interest in understanding the mechanisms used by this parasite that causes a modulation of the immune system. Recent studies from our group demonstrated that lipids of S. mansoni, including lysophosphatidylcholine (LPC) have immunomodulatory activity. In the present study, our aim was to investigate the role of lipids derived from S...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27869490/congenital-diaphragmatic-hernia-causing-cardiac-arrest-in-a-30-year-old-woman
#12
H J Manson, Y M Goh, P Goldsmith, P Scott, P Turner
Congenital diaphragmatic hernia (CDH) usually presents in infancy with respiratory failure requiring urgent surgical correction. Mortality in this group of patients remains poor and persistent pulmonary hypertension is a significant contributor. It is therefore rare for patients to reach adulthood undiagnosed. CDH is often identified incidentally in adults but when symptoms arise, they relate to the organ involved, and include gastrointestinal symptoms of dyspepsia and obstruction, as well as respiratory complaints such as dyspnoea...
November 21, 2016: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/27831499/association-of-traditional-cardiovascular-risk-factors-with-venous-thromboembolism-an-individual-participant-data-meta-analysis-of-prospective-studies
#13
Bakhtawar K Mahmoodi, Mary Cushman, Inger Anne Næss, Matthew A Allison, Willem Jan Bos, Sigrid K Brækkan, Suzanne Cannegieter, Ron T Gansevoort, Philimon N Gona, Jens Hammerstrøm, John-Bjarne Hansen, Susan Heckbert, Anders G Holst, Susan G Lakoski, Pamela L Lutsey, JoAnn E Manson, Lisa W Martin, Kunihiro Matsushita, Karina Meijer, Kim Overvad, Eva B Prescott, Marja K Puurunen, Jacques Rossouw, Yingying Sang, Marianne T Severinsen, Jur M Ten Berg, Aaron R Folsom, Neil A Zakai
BACKGROUND: -There is much controversy surrounding the association of traditional cardiovascular disease (CVD) risk factors with venous thromboembolism (VTE). METHODS: - We performed an individual level random-effect meta-analysis including 9 prospective studies with measured baseline CVD risk factors and validated VTE events. Definitions were harmonized across studies. Traditional CVD risk factors were modeled categorically, as well as continuously using restricted cubic splines...
November 9, 2016: Circulation
https://www.readbyqxmd.com/read/27829162/second-trimester-amniotic-fluid-bisphenol-a-concentration-is-associated-with-decreased-birth-weight-in-term-infants
#14
Sara E Pinney, Clementina A Mesaros, Nathaniel W Snyder, Christine M Busch, Rui Xiao, Sara Aijaz, Naila Ijaz, Ian A Blair, Jeanne M Manson
Bisphenol A (BPA) is an endocrine disrupting chemical with ubiquitous environmental exposure. Animal studies have demonstrated that in utero BPA exposure leads to increased adult body weight. Our aim was to characterize human fetal BPA exposure by measuring BPA concentration in second trimester amniotic fluid (AF) samples and to study its relationship with birth weight (BW) in full term infants. To achieve these goals, we developed a total BPA assay utilizing derivatization with pentafluorobenzyl followed by analysis with LC-ECAPCI-MS/MS with a limit of detection of 0...
November 6, 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27824550/chikungunya-virus-infection-an-update-on-joint-manifestations-and-management
#15
REVIEW
Maria Krutikov, Jessica Manson
The advent of sophisticated diagnostics has enabled the discovery of previously unknown arthropod-borne viruses like Chikungunya. This infection has become increasingly prevalent in the last 10 years across the Indian Ocean and has been brought to media attention by a recent outbreak in the Caribbean. The outbreak has been aided by a drastic rise in air travel, allowing infected individuals to transport the virus to previously unaffected regions. In addition, a recently documented viral mutation has allowed its transmission by the Aedes albopictus mosquito, therefore facilitating outbreaks in Southern Europe and the USA...
October 31, 2016: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/27823759/are-antibiotic-nails-effective-in-the-treatment-of-infected-tibial-fractures
#16
Rachel M Reilly, Thomas Robertson, Robert V O'Toole, Theodore T Manson
BACKGROUND: Antibiotic-impregnated cement nails are used to treat postoperative deep infections after primary intramedullary nail insertion for the treatment of tibial fractures. Few data exist regarding the efficacy of this treatment strategy. We hypothesized that such treatment with antibiotic nails results in a high rate of infection clearance at intermediate follow-up. METHODS: We conducted a retrospective review at our Level I trauma center. Patients who received intramedullary nails to stabilize tibial fractures (from 2000 to 2011) and subsequently required antibiotic nails to treat deep postoperative infection (n=55) were considered for study inclusion...
December 2016: Injury
https://www.readbyqxmd.com/read/27820659/no-increase-in-fractures-after-stopping-hormone-therapy-results-from-the-women-s-health-initiative
#17
Nelson B Watts, Jane A Cauley, Rebecca D Jackson, Andrea Z LaCroix, Cora E Lewis, JoAnn E Manson, Joan Neuner, Lawrence S Phillips, Marcia L Stefanick, Jean Wactawski-Wende, Carolyn Crandall
CONTEXT: The Women's Health Initiative (WHI) hormone therapy (HT) trials showed protection against hip and total fractures but a later observational report suggested loss of benefit and a rebound increased risk after stopping. OBJECTIVE: To examine fractures after discontinuation of HT Design and Setting: Two placebo-controlled randomized trials Patients: 15,187 WHI participants who continued active HT or placebo through the intervention period and did not take HT in the post-intervention period Interventions: Conjugated equine estrogen + medroxyprogesterone acetate (CEE+MPA) in naturally menopausal women and conjugated equine estrogen (CEE) alone in women with prior hysterectomy Main Outcome Measures: Total and hip fractures through 5 years after discontinuation Results: Hip fractures were infrequent (∼2...
November 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27802499/consideration-of-sex-differences-in-medicine-to-improve-health-care-and-patient-outcomes
#18
Marianne J Legato, Paula A Johnson, JoAnn E Manson
No abstract text is available yet for this article.
November 8, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27797938/leucocyte-telomere-length-genetic-variants-at-the-tert-gene-region-and-risk-of-pancreatic-cancer
#19
Ying Bao, Jennifer Prescott, Chen Yuan, Mingfeng Zhang, Peter Kraft, Ana Babic, Vicente Morales-Oyarvide, Zhi Rong Qian, Julie E Buring, Barbara B Cochrane, J Michael Gaziano, Edward L Giovannucci, JoAnn E Manson, Kimmie Ng, Shuji Ogino, Thomas E Rohan, Howard D Sesso, Meir J Stampfer, Charles S Fuchs, Immaculata De Vivo, Laufey T Amundadottir, Brian M Wolpin
OBJECTIVE: Telomere shortening occurs as an early event in pancreatic tumorigenesis, and genetic variants at the telomerase reverse transcriptase (TERT) gene region have been associated with pancreatic cancer risk. However, it is unknown whether prediagnostic leucocyte telomere length is associated with subsequent risk of pancreatic cancer. DESIGN: We measured prediagnostic leucocyte telomere length in 386 pancreatic cancer cases and 896 matched controls from five prospective US cohorts...
October 21, 2016: Gut
https://www.readbyqxmd.com/read/27796821/protective-effects-of-statins-in-cancer-should-they-be-prescribed-for-high-risk-patients
#20
REVIEW
Ange Wang, Heather A Wakelee, Aaron K Aragaki, Jean Y Tang, Allison W Kurian, JoAnn E Manson, Marcia L Stefanick
PURPOSE OF REVIEW: Statins are one of the most widely prescribed drug classes in the USA. This review aims to summarize recent research on the relationship between statin use and cancer outcomes, in the context of clinical guidelines for statin use in patients with cancer or who are at high risk for cancer. RECENT FINDINGS: A growing body of research has investigated the relationship between statins and cancer with mixed results. Cancer incidence has been more extensively studied than cancer survival, though results are inconsistent as some large meta-analyses have not found an association, while other studies have reported improved cancer outcomes with the use of statins...
December 2016: Current Atherosclerosis Reports
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