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https://www.readbyqxmd.com/read/29659835/anti-m%C3%A3-llerian-hormone-levels-and-incidence-of-early-natural-menopause-in-a-prospective-study
#1
Elizabeth R Bertone-Johnson, JoAnn E Manson, Alexandra C Purdue-Smithe, Anne Z Steiner, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Brian W Whitcomb
STUDY QUESTION: Are anti-Müllerian hormone (AMH) levels assessed in women aged 32-44 associated with risk of incident early natural menopause? SUMMARY ANSWER: We observed strong, significant associations between lower AMH levels and higher risk of early menopause. WHAT IS KNOWN ALREADY: The ability to predict risk early menopause, defined as menopause before age 45, prior to fertility decline would improve options for family planning and cardiovascular disease prevention...
April 5, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29659459/pediatric-zygomaticomaxillary-complex-fracture-repair-location-and-number-of-fixation-sites-in-growing-children
#2
J D Luck, Joseph Lopez, Muhammad Faateh, Alexandra Macmillan, Robin Yang, Edward H Davidson, Arthur Nam, Michael Grant, Anthony P Tufaro, Richard Redett, Paul N Manson, Amir H Dorafshar
BACKGROUND: Currently, there is a relative paucity of data investigating the operative management of displaced pediatric zygomaticomaxillary complex (ZMC) fractures. The purpose of this study was to assess ZMC fracture management and associated complications in the pediatric population, and potentially describe a standard treatment paradigm for pediatric ZMC fractures. METHODS: A retrospective cohort review was performed of all patients younger than 15 years-of-age presenting to a single institution with ZMC fractures from 1990-2010...
April 5, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29658911/concern-about-us-preventive-services-task-force-recommendation-on-hormone-therapy-for-the-primary-prevention-of-chronic-conditions-in-postmenopausal-women
#3
JoAnn V Pinkerton, Andrew M Kaunitz, JoAnn E Manson
No abstract text is available yet for this article.
May 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29615502/postgenomics-characterization-of-an-essential-genetic-determinant-of-mammary-pathogenic-escherichia-coli
#4
Shlomo E Blum, Robert J Goldstone, James P R Connolly, Maryline Répérant-Ferter, Pierre Germon, Neil F Inglis, Oleg Krifucks, Shubham Mathur, Erin Manson, Kevin Mclean, Pascal Rainard, Andrew J Roe, Gabriel Leitner, David G E Smith
Escherichia coli are major bacterial pathogens causing bovine mastitis, a disease of great economic impact on dairy production worldwide. This work aimed to study the virulence determinants of mammary pathogenic E. coli (MPEC). By whole-genome sequencing analysis of 40 MPEC and 22 environmental ("dairy-farm" E. coli [DFEC]) strains, we found that only the fec locus ( fecIRABCDE ) for ferric dicitrate uptake was present in the core genome of MPEC and that it was absent in DFEC genomes ( P < 0...
April 3, 2018: MBio
https://www.readbyqxmd.com/read/29608241/an-analysis-of-the-effect-of-statins-on-the-risk-of-non-hodgkin-s-lymphoma-in-the-women-s-health-initiative-cohort
#5
Pinkal Desai, Robert Wallace, Matthew L Anderson, Barbara V Howard, Roberta Ray, Chunyuan Wu, Monika Safford, Lisa W Martin, Nicolas Schlecht, Simin Liu, Dominic Cirillo, Allison Jay, JoAnn E Manson, Michael S Simon
Statins have been shown to induce a phosphoprotein signature that modifies MYC (myelocytomatosis viral oncogene) activation and to have anti-inflammatory activity that may impact the risk of Non-Hodgkin's lymphoma (NHL). We analyzed the relationship between statins and risk of NHL using data from the Women's Health Initiative (WHI). The study population included 161,563 postmenopausal women ages 50-79 years from which 712 cases of NHL were diagnosed after 10.8 years of follow-up. Information on statin use and other risk factors was collected by self- and interviewer-administered questionnaires...
April 2, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29579500/nursing-duties-and-accreditation-standards-and-their-impacts-the-nursing-perspective
#6
Parneet Jaggi, Rhonda Tomlinson, Kirstie McLelland, Warren Ma, Carol Manson-McLeod, Michael J Bullard
BACKGROUND: Medical advances and increasingly complex patients presenting to the Emergency Department (ED) make nursing challenging. Gaining new knowledge and skills is a perpetual requirement. New quality initiatives to improve patient safety and care are being constantly introduced and create significant work and time pressures for healthcare providers involved. STUDY QUESTION: Do ED nurses support the introduction of new quality standards, in addition to their current heavy workload? STUDY DESIGN: A cross-sectional survey...
April 2018: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29572205/circulating-branched-chain-amino-acids-and-incident-cardiovascular-disease-in-a-prospective-cohort-of-us-women
#7
Deirdre K Tobias, Patrick R Lawler, Paulo H Harada, Olga V Demler, Paul M Ridker, JoAnn E Manson, Susan Cheng, Samia Mora
BACKGROUND: Circulating branched-chain amino acids (BCAAs; isoleucine, leucine, and valine) are strong predictors of type 2 diabetes mellitus (T2D), but their association with cardiovascular disease (CVD) is uncertain. We hypothesized that plasma BCAAs are positively associated with CVD risk and evaluated whether this was dependent on an intermediate diagnosis of T2D. METHODS: Participants in the Women's Health Study prospective cohort were eligible if free of CVD at baseline blood collection (n=27 041)...
April 2018: Circulation. Genomic and precision medicine
https://www.readbyqxmd.com/read/29557848/hormonal-contraception-and-risk-of-breast-cancer-a-closer-look
#8
Andrew M Kaunitz, JoAnn V Pinkerton, JoAnn E Manson
No abstract text is available yet for this article.
March 19, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29549290/implications-of-bond-disorder-in-a-s-1-kagome-lattice
#9
Jamie L Manson, Jamie Brambleby, Paul A Goddard, Peter M Spurgeon, Jacqueline A Villa, Junjie Liu, Saman Ghannadzadeh, Francesca Foronda, John Singleton, Tom Lancaster, Stewart J Clark, Iorwerth O Thomas, Fan Xiao, Robert C Williams, Francis L Pratt, Stephen J Blundell, Craig V Topping, Christopher Baines, Charles Campana, Bruce Noll
Strong hydrogen bonds such as F···H···F offer new strategies to fabricate molecular architectures exhibiting novel structures and properties. Along these lines and, to potentially realize hydrogen-bond mediated superexchange interactions in a frustrated material, we synthesized [H2 F]2 [Ni3 F6 (Fpy)12 ][SbF6 ]2 (Fpy = 3-fluoropyridine). It was found that positionally-disordered H2 F+ ions link neutral NiF2 (Fpy)4 moieties into a kagome lattice with perfect 3-fold rotational symmetry. Detailed magnetic investigations combined with density-functional theory (DFT) revealed weak antiferromagnetic interactions (J ~ 0...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29534990/neighborhood-characteristics-and-lifestyle-intervention-outcomes-results-from-the-special-diabetes-program-for-indians
#10
Luohua Jiang, Jenny Chang, Janette Beals, Ann Bullock, Spero M Manson
Growing evidence reveals various neighborhood conditions are associated with the risk of developing type 2 diabetes. It is unknown, however, whether the effectiveness of diabetes prevention interventions is also influenced by neighborhood characteristics. The purpose of the current study is to examine the impact of neighborhood characteristics on the outcomes of a lifestyle intervention to prevent diabetes in American Indians and Alaska Natives (AI/ANs). Year 2000 US Census Tract data were linked with those from the Special Diabetes Program for Indians Diabetes Prevention Program (SDPI-DP), an evidence-based lifestyle intervention implemented in 36 AI/AN grantee sites across the US...
March 10, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29529162/carbohydrate-quality-and-quantity-and-risk-of-coronary-heart-disease-among-us-women-and-men
#11
Hala B AlEssa, Randy Cohen, Vasanti S Malik, Sally N Adebamowo, Eric B Rimm, JoAnn E Manson, Walter C Willett, Frank B Hu
Background: The carbohydrate-to-fiber ratio is a recommended measure of carbohydrate quality; however, its relation to incident coronary heart disease (CHD) is not currently known. Objective: We aimed to assess the relation between various measures of carbohydrate quality and incident CHD. Design: Data on diet and lifestyle behaviors were prospectively collected on 75,020 women and 42,865 men participating in the Nurses' Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS) starting in 1984 and 1986, respectively, and every 2-4 y thereafter until 2012...
February 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29526608/the-vitamin-d-and-omega-3-trial-depression-endpoint-prevention-vital-dep-rationale-and-design-of-a-large-scale-ancillary-study-evaluating-vitamin-d-and-marine-omega-3-fatty-acid-supplements-for-prevention-of-late-life-depression
#12
Olivia I Okereke, Charles F Reynolds, David Mischoulon, Grace Chang, Nancy R Cook, Trisha Copeland, Georgina Friedenberg, Julie E Buring, JoAnn E Manson
RATIONALE: Depression is a leading cause of disease burden and disability for older adults; thus, prevention is a priority. Biologic and observational data support potential mental health benefits of vitamin D and omega-3 fatty acids; however, it is unclear whether these supplements can prevent late-life depression. DESIGN: We describe the novel methodology of a large-scale prevention study: VITAL-DEP (VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention), an ancillary to the VITAL trial...
March 8, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29506982/obesity-progression-between-young-adulthood-and-midlife-and-incident-diabetes-a-retrospective-cohort-study-of-u-s-adults
#13
Andrew Stokes, Jason M Collins, Bethany F Grant, Robin F Scamuffa, Chia-Wen Hsiao, Stephen S Johnston, Eric M Ammann, JoAnn E Manson, Samuel H Preston
OBJECTIVE: Understanding how changes in weight over the life course shape risk for diabetes is critical for the prevention of diabetes. Using data from the National Health and Nutrition Examination Survey (NHANES), we investigated the association between self-reported weight change from young adulthood to midlife and incident diabetes. RESEARCH DESIGN AND METHODS: We categorized individuals into four weight-change groups: those who remained nonobese (stable nonobese), those who moved from an obese BMI to a nonobese BMI (losing), those who moved from a nonobese BMI to an obese BMI (gaining), and those who remained obese (stable obese)...
March 5, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29501136/rapid-and-robust-analytical-protocol-for-e-coli-stec-bacteria-subspecies-differentiation-using-whole-cell-maldi-mass-spectrometry
#14
Kevin Mclean, Javier Palarea-Albaladejo, Carol G Currie, Lisa H J Imrie, Erin D T Manson, Douglas Fraser-Pitt, Frank Wright, Colin J Alexander, Kevin G J Pollock, Lesley Allison, Mary Hanson, David G E Smith
Whole cell MALDI is regularly used for the identification of bacteria to species level in clinical Microbiology laboratories. However, there remains a need to rapidly characterize and differentiate isolates below the species level to support outbreak management. We describe the implementation of a modified preparative approach for MALDI-MS combined with a custom analytical computational pipeline as a rapid procedure for subtyping Shigatoxigenic E. coli (STEC) and accurately identifying strain-specifying biomarkers...
May 15, 2018: Talanta
https://www.readbyqxmd.com/read/29499126/contemporary-management-of-mandibular-fracture-nonunion-a-retrospective-review-and-treatment-algorithm
#15
Benjamin T Ostrander, Howard D Wang, Alessandro Cusano, Paul N Manson, Arthur J Nam, Amir H Dorafshar
PURPOSE: Nonunion is an uncommon complication after mandibular fractures. The purpose of this investigation was to compare outcomes of patients with mandibular fracture nonunion who were treated with a 1- versus 2-stage approach and propose a pragmatic treatment algorithm for surgical management based on preoperative characteristics. MATERIALS AND METHODS: The authors conducted a retrospective study consisting of patients who presented to 2 level 1 trauma centers for the management of mandibular fracture nonunion over a 10-year period...
February 6, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29497459/treatment-of-uveal-melanoma-where-are-we-now
#16
REVIEW
Jessica Yang, Daniel K Manson, Brian P Marr, Richard D Carvajal
Uveal melanoma, a rare subset of melanoma, is the most common primary intraocular malignancy in adults. Despite effective primary therapy, nearly 50% of patients will develop metastatic disease. Outcomes for those with metastatic disease remain dismal due to a lack of effective therapies. The unique biology and immunology of uveal melanoma necessitates the development of dedicated management and treatment approaches. Ongoing efforts seek to optimize the efficacy of targeted therapy and immunotherapy in both the adjuvant and metastatic setting...
2018: Therapeutic Advances in Medical Oncology
https://www.readbyqxmd.com/read/29493798/what-the-women-s-health-initiative-has-taught-us-about-menopausal-hormone-therapy
#17
REVIEW
Rebecca C Chester, Juliana M Kling, JoAnn E Manson
Our understanding of the complex relationship between menopausal hormone therapy (MHT) and cardiovascular disease (CVD) risk has been informed by detailed analyses in the Women's Health Initiative (WHI), the largest randomized, placebo-controlled trial evaluating MHT in postmenopausal women. Although the WHI demonstrated increased risk of CVD events with MHT in the overall cohort, subsequent secondary analyses demonstrated that these risks were influenced by the woman's age and time since menopause, with lower absolute risks and hazard ratios for younger than older women...
March 1, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29490688/the-effects-of-interventions-targeting-multiple-health-behaviors-on-smoking-cessation-outcomes-a-rapid-realist-review-protocol
#18
Nadia Minian, Wayne K deRuiter, Mathangee Lingam, Tricia Corrin, Rosa Dragonetti, Heather Manson, Valerie H Taylor, Laurie Zawertailo, Arezoo Ebnahmady, Osnat C Melamed, Terri Rodak, Margaret Hahn, Peter Selby
BACKGROUND: Health behaviors directly impact the health of individuals, and populations. Since individuals tend to engage in multiple unhealthy behaviors such as smoking, excessive alcohol use, physical inactivity, and eating an unhealthy diet simultaneously, many large community-based interventions have been implemented to reduce the burden of disease through the modification of multiple health behaviors. Smoking cessation can be particularly challenging as the odds of becoming dependent on nicotine increase with every unhealthy behavior a smoker exhibits...
March 1, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29483073/the-combined-association-of-modifiable-risk-factors-with-breast-cancer-risk-in-the-women-s-health-initiative
#19
Rhonda Arthur, Sylvia Wassertheil-Smoller, JoAnn E Manson, Juhua Luo, Linda Snetselaar, Theresa Hastert, Bette Caan, Lihong Qi, Thomas Rohan
Although several modifiable risk factors have been independently associated with risk of breast cancer, few studies have investigated their joint association with breast cancer risk. Using a healthy lifestyle index (HLI) score, we assessed the association of a combination of selected modifiable risk factors (diet, alcohol, physical activity, BMI and smoking) with risk of invasive breast cancer in the Women's Health Initiative (WHI). This study comprised 131,833 postmenopausal women, of whom 8168 had breast cancer, who were enrolled in the WHI Observational Study or the WHI clinical trials...
February 26, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29479467/patient-provider-relationship-and-perceived-provider-weight-bias-among-american-indians-and-alaska-natives
#20
K L Gonzales, G E Garcia, M M Jacob, C Muller, L Nelson, S M Manson
Objective: The objective of this study was to examine patient-provider relationships among American Indians and Alaska Native (AI/AN) patients by examining associations between patient activation, perceived provider weight bias and working alliance. Patient activation is generally defined as having the knowledge, skills and confidence to manage one's health. Methods: Among a sample of 87 AI/AN adults presenting for general medical care at an urban clinic in the north-west region of the USA, ordinary least squares regression analysis was completed to examine associations...
February 2018: Obesity Science & Practice
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