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https://www.readbyqxmd.com/read/28350909/vitamin-d-calcium-and-cancer-approaching-daylight
#1
JoAnn E Manson, Shari S Bassuk, Julie E Buring
No abstract text is available yet for this article.
March 28, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28338878/risk-of-diabetes-after-hysterectomy-with-or-without-oophorectomy-in-postmenopausal-women
#2
Juhua Luo, JoAnn E Manson, Rachel Peragallo Urrutia, Michael Hendryx, Erin S LeBlanc, Karen L Margolis
The aim of this study was to determine the associations between hysterectomy, bilateral salpingo-oophorectomy (BSO), and incidence of diabetes in postmenopausal women participating in the Women's Health Initiative (WHI), a series of trials conducted in the United States, during the period 1993-1998. A total of 67,130 postmenopausal women aged 50-79 years were followed for a mean of 13.4 years. Among them, 7,430 cases of diabetes were diagnosed. Multivariable Cox proportional hazards models were used to assess the association between hysterectomy/oophorectomy status and diabetes incidence...
March 6, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28330863/bacterial-virulence-phenotypes-of-escherichia-coli-and-host-susceptibility-determine-risk-for-urinary-tract-infections
#3
Henry L Schreiber, Matt S Conover, Wen-Chi Chou, Michael E Hibbing, Abigail L Manson, Karen W Dodson, Thomas J Hannan, Pacita L Roberts, Ann E Stapleton, Thomas M Hooton, Jonathan Livny, Ashlee M Earl, Scott J Hultgren
Urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC) strains. In contrast to many enteric E. coli pathogroups, no genetic signature has been identified for UPEC strains. We conducted a high-resolution comparative genomic study using E. coli isolates collected from the urine of women suffering from frequent recurrent UTIs. These isolates were genetically diverse and varied in their urovirulence, that is, their ability to infect the bladder in a mouse model of cystitis. We found no set of genes, including previously defined putative urovirulence factors (PUFs), that were predictive of urovirulence...
March 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28326193/associations-of-diabetes-and-obesity-with-risk-of-abdominal-aortic-aneurysm-in-men
#4
Lu Wang, Luc Djousse, Yiqing Song, Akintunde O Akinkuolie, Chisa Matsumoto, JoAnn E Manson, J Michael Gaziano, Howard D Sesso
Background. The associations of diabetes and obesity with the risk of abdominal aortic aneurysm (AAA) are inconclusive in previous studies. Subjects/Methods. We conducted prospective analysis in the Physicians' Health Study. Among 25,554 male physicians aged ≥ 50 years who reported no AAA at baseline, 471 reported a newly diagnosed AAA during a mean of 10.4 years' follow-up. Results. Compared with men who had baseline body mass index (BMI) < 25 kg/m(2), the multivariable hazard ratio (HR [95% CI]) of newly diagnosed AAA was 1...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28323934/menopausal-hormone-therapy-and-type-2-diabetes-prevention-evidence-mechanisms-and-clinical-implications
#5
Franck Mauvais-Jarvis, JoAnn E Manson, John C Stevenson, Vivian A Fonseca
Type 2 diabetes has reached epidemic proportions in the US. Large randomized controlled trials suggest that menopausal hormone therapy (MHT) delays the onset of type 2 diabetes in women. Still, the mechanisms and clinical implications of these associations are a matter of controversy. This review provides an up-to-date analysis and integration of epidemiological, clinical and basic studies, and proposes a mechanistic explanation for the effect of menopause and MHT on type 2 diabetes development and prevention...
March 8, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28323795/assessment-of-severe-extremity-wound-bioburden-at-the-time-of-definitive-wound-closure-or-coverage-correlation-with-subsequent-postclosure-deep-wound-infection-bioburden-study
#6
Michael J Bosse, Clinton K Murray, Anthony R Carlini, Reza Firoozabadi, Theodore Manson, Daniel O Scharfstein, Joseph C Wenke, Mary Zadnik, Renan C Castillo
Infection remains the most common and significant complication after high-energy fractures. The Bioburden Study is a multicenter, prospective, observational cohort study of wound bacterial bioburden and antibiotic care in severe open lower extremity fractures. The aims of this study are to (1) characterize the contemporary extremity wound "bioburden" at the time of definitive wound closure; (2) determine the concordance between polymerase chain reaction results and hospital microbiology; (3) determine, among those who develop deep infections, the concordance between the pathogens at wound closure and at deep infection; and (4) compare the probability of deep infection between those who did and did not receive an appropriate course of antibiotics based on bioburden at the time of wound closure...
April 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28320576/platelet-count-and-total-and-cause-specific-mortality-in-the-women-s-health-initiative
#7
Geoffrey C Kabat, Mimi Y Kim, Amit K Verma, JoAnn E Manson, Juan Lin, Lawrence Lessin, Sylvia Wassertheil-Smoller, Thomas E Rohan
PURPOSE: We used data from the Women's Health Initiative to examine the association of platelet count with total mortality, coronary heart disease (CHD) mortality, cancer mortality, and non-CHD/noncancer mortality. METHODS: Platelet count was measured at baseline in 159,746 postmenopausal women and again in year 3 in 75,339 participants. Participants were followed for a median of 15.9 years. Cox proportional hazards models were used to estimate the relative mortality hazards associated with deciles of baseline platelet count and of the mean of baseline + year 3 platelet count...
February 21, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28292922/the-association-of-the-c-reactive-protein-inflammatory-biomarker-with-breast-cancer-incidence-and-mortality-in-the-women-s-health-initiative
#8
Sandahl H Nelson, Theodore M Brasky, Ruth E Patterson, Gail A Laughlin, Donna Kritz-Silverstein, Beatrice J Edwards, Dorothy Lane, Thomas E Rohan, Gloria Y F Ho, JoAnn E Manson, Andrea Z LaCroix
PURPOSE: To examine associations of pre-diagnosis high-sensitivity C-reactive (hsCRP) with breast cancer incidence and post-diagnosis survival and to assess whether associations are modified by Body Mass Index (BMI). METHODS: A prospective analysis of the Women's Health Initiative was conducted among 17,841 cancer free postmenopausal women with baseline hsCRP measurements. Cox proportional hazards models were used to examine associations between hsCRP concentrations and: 1) breast cancer risk (n cases=1,114) and 2) all-cause mortality after breast cancer diagnosis...
March 14, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28284224/anthropometric-measures-and-serum-estrogen-metabolism-in-postmenopausal-women-the-women-s-health-initiative-observational-study
#9
Hannah Oh, Sally B Coburn, Charles E Matthews, Roni T Falk, Erin S LeBlanc, Jean Wactawski-Wende, Joshua Sampson, Ruth M Pfeiffer, Louise A Brinton, Nicolas Wentzensen, Garnet L Anderson, JoAnn E Manson, Chu Chen, Oleg Zaslavsky, Xia Xu, Britton Trabert
BACKGROUND: Several anthropometric measures have been associated with hormone-related cancers. However, it is unknown whether estrogen metabolism plays an important role in these relationships. We examined whether measured current body mass index (BMI), waist-to-hip ratio (WHR), height, and self-reported BMI at age 18 years were associated with serum estrogens/estrogen metabolites using baseline, cross-sectional data from 1835 postmenopausal women enrolled in the Women's Health Initiative Observational Study...
March 11, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28277203/assessing-continuous-quality-improvement-in-public-health-adapting-lessons-from-healthcare
#10
Alex Price, Robert Schwartz, Joanna Cohen, Heather Manson, Fran Scott
CONTEXT: Evidence of the effect of continuous quality improvement (CQI) in public health and valid tools to judge that such effects are not fully formed. OBJECTIVE: The objective was to adapt and apply Shortell et al.'s (1998) four dimensions of CQI in an examination of a public health accountability and performance management initiative in Ontario, Canada. METHODS: In total, 24 semi-structured, in-depth interviews were conducted with informants from public health units and the Ministry of Health and Long-Term Care...
February 2017: Healthcare Policy, Politiques de Santé
https://www.readbyqxmd.com/read/28270452/efficacy-and-tolerability-of-nivolumab-after-allogeneic-transplantation-for-relapsed-hodgkin-s-lymphoma
#11
Charles Herbaux, Jordan Gauthier, Pauline Brice, Elodie Drumez, Loic Ysebaert, Hélène Doyen, Luc Fornecker, Krimo Bouabdallah, Guillaume Manson, Hervé Ghesquières, Reza Tabrizi, Eric Hermet, Julien Lazarovici, Anne Thiebaut-Bertrand, Adrien Chauchet, Hélène Demarquette, Eileen Boyle, Roch Houot, Ibrahim Yakoub-Agha, Franck Morschhauser
Allogeneic hematopoietic cell transplantation (allo-HCT) is indicated for patients with relapsed and refractory Hodgkin lymphoma (HL). While long-term disease control can be achieved, relapse remains frequent. The programmed death 1 (PD-1) blocking antibody nivolumab has shown substantial therapeutic activity and an acceptable safety profile in relapsed and refractory HL who did not receive allo-HCT. However, PD-1-blocking strategy can increase the risk of Graft Versus Host Disease (GVHD) in murine models. We retrospectively assessed the efficacy and toxicity of nivolumab as a single agent in 20 HL patients relapsing after allo-HCT...
March 7, 2017: Blood
https://www.readbyqxmd.com/read/28249081/management-of-type-2-diabetes-in-2017-getting-to-goal
#12
Jane E B Reusch, JoAnn E Manson
No abstract text is available yet for this article.
March 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28245140/correlation-of-lci-with-hyperpolarized-129-xe-magnetic-resonance-imaging-in-pediatric-cf-subjects
#13
Nikhil Kanhere, Marcus J Couch, Krzysztof Kowalik, Brandon Zanette, Jonathan H Rayment, David Manson, Padmaja Subbarao, Felix Ratjen, Giles Santyr
No abstract text is available yet for this article.
February 28, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28231077/association-of-genetic-variation-in-the-tachykinin-receptor-3-locus-with-hot-flashes-and-night-sweats-in-the-women-s-health-initiative-study
#14
Carolyn J Crandall, JoAnn E Manson, Chancellor Hohensee, Steve Horvath, Jean Wactawski-Wende, Erin S LeBlanc, Mara Z Vitolins, Rami Nassir, Janet S Sinsheimer
OBJECTIVE: Vasomotor symptoms (VMS, ie, hot flashes or night sweats) are reported by many, but not all, women. The extent to which VMS are genetically determined is unknown. We evaluated the relationship of genetic variation and VMS. METHODS: In this observational study, we accessed data from three genome-wide association studies (GWAS) (SNP Health Association Resource cohort [SHARe], WHI Memory Study cohort [WHIMS+], and Genome-Wide Association Studies of Treatment Response in Randomized Clinical Trials [GARNET] studies, total n = 17,695) of European American, African American, and Hispanic American postmenopausal women aged 50 to 79 years at baseline in the Women's Health Initiative Study...
March 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28228526/trimethylamine-n-oxide-stabilizes-proteins-via-a-distinct-mechanism-compared-with-betaine-and-glycine
#15
Yi-Ting Liao, Anthony C Manson, Michael R DeLyser, William G Noid, Paul S Cremer
We report experimental and computational studies investigating the effects of three osmolytes, trimethylamine N-oxide (TMAO), betaine, and glycine, on the hydrophobic collapse of an elastin-like polypeptide (ELP). All three osmolytes stabilize collapsed conformations of the ELP and reduce the lower critical solution temperature (LSCT) linearly with osmolyte concentration. As expected from conventional preferential solvation arguments, betaine and glycine both increase the surface tension at the air-water interface...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28215073/identification-of-highly-specific-diversity-oriented-synthesis-derived-inhibitors-of-clostridium-difficile
#16
Jeremy R Duvall, Leanne Bedard, Adel M Naylor-Olsen, Abigail L Manson, Joshua A Bittker, Wenye Sun, Mark E Fitzgerald, Zhenmin He, Maurice D Lee, Jean-Charles Marie, Giovanni Muncipinto, Diane Rush, Deming Xu, Huisheng Xu, Mingliang Zhang, Ashlee M Earl, Michelle A Palmer, Michael A Foley, Joseph P Vacca, Christina A Scherer
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of which result in disease relapse. We sought to identify molecules specifically targeting C. difficile in high-throughput screens of our diversity-oriented synthesis compound collection. We identified two scaffolds with apparently novel mechanisms of action that selectively target C...
March 7, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28199338/development-and-application-of-an-edna-method-to-detect-the-critically-endangered-trinidad-golden-tree-frog-phytotriades-auratus-in-bromeliad-phytotelmata
#17
Sarah Brozio, Chloe Manson, Eleanor Gourevitch, Thomas J Burns, Mark S Greener, J Roger Downie, Paul A Hoskisson
The use of environmental DNA (eDNA) to monitor rare and elusive species has great potential for conservation biology. Traditional surveying methods can be time-consuming, labour-intensive, subject to error or can be invasive and potentially damaging to habitat. The Trinidad golden treefrog (Phytotriades auratus) is one such species that would benefit from such an approach. This species inhabits the giant bromeliad (Glomeropitcairnia erectiflora) on two peaks on the Caribbean island of Trinidad. Traditional survey methods for this species have required the destruction of the giant bromeliad, which is the only known habitat of this frog...
2017: PloS One
https://www.readbyqxmd.com/read/28198537/racial-discrimination-associated-with-higher-diastolic-blood-pressure-in-a-sample-of-american-indian-adults
#18
Zaneta M Thayer, Irene V Blair, Dedra S Buchwald, Spero M Manson
OBJECTIVES: Hypertension prevalence is high among American Indians (AIs). AIs experience a substantial burden of interpersonal racial discrimination, which in other populations has been associated with higher blood pressure. The purpose of this study is to understand whether racial discrimination experiences are associated with higher blood pressure in AIs. MATERIALS AND METHODS: We used the Everyday Discrimination Scale to evaluate the relationship between discrimination and measured blood pressure among 77 AIs from two reservation communities in the Northern Plains...
February 15, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28187072/predictors-of-blood-transfusion-in-posterior-lumbar-spinal-fusion-a-canadian-spine-outcome-and-research-network-csorn-study
#19
Mina W Morcos, Fan Jiang, Greg McIntosh, Michael Johnson, Sean Christie, Eugene Wai, Jean Ouellet, Chris Bailey, Henry Ahn, Jerome Paquet, Neil Manson, Charles Fisher, Raja Rampersaud, Ken Thomas, Hamilton Hall, Michael Weber
STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To identify patient or procedure related predictors of postoperative blood transfusions in posterior lumbar fusion (PSF). SUMMARY OF BACKGROUND DATA: The rate of PSF surgery has increased significantly. It remains the most common surgical procedure used to stabilize the spine; however, the impact of blood loss requiring blood transfusions remains a significant concern. METHODS: Analysis of data from the Canadian Spine Outcomes and Research Network...
February 9, 2017: Spine
https://www.readbyqxmd.com/read/28183112/new-records-of-eriophyoid-mites-from-iran-acari-trombidiformes-eriophyoidea-and-a-description-of-a-new-i-brevulacus-i-manson-species
#20
Grażyna Soika, Ali Gol, Arash Honarmand, Anna Wozińska, Hussein Sadeghi
Four species of eriophyoid mites are recorded from Iran, of which three represent new records and the other is a new species. These species are: Brevulacus salicinus n. sp. (Diptilomiopidae), found on Salix sp. (Salicaceae); Aceria wallichianae Keifer, 1975 from Ulmus minor (Ulmaceae); Aceria granulata Carmona, 1972 from Verbascum spp. (Scrophulariaceae) and Tegnacus unicornutus Pye, 2012 from Carpinus betulus (Betulaceae). Each of these species are illustrated and provided with data regarding their distribution and host plants...
January 9, 2017: Zootaxa
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