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Chris Gustin, Ross Manson, Stephen Hughes
We present an open-system master equation study of the coherent and incoherent resonance fluorescence spectrum from a two-level quantum system under coherent pulsed excitation. Several pronounced features that differ from the fluorescence under a constant drive are highlighted, including a multi-peak structure and a pronounced off-resonant spectral asymmetry, in stark contrast to the conventional symmetrical Mollow triplet. We also study semiconductor quantum dot systems using a polaron master equation and show how the key features of dynamic resonance fluorescence change with electron-acoustic-phonon coupling...
February 15, 2018: Optics Letters
Phil A Crosbie, Haval Balata, Matthew Evison, Melanie Atack, Val Bayliss-Brideaux, Denis Colligan, Rebecca Duerden, Josephine Eaglesfield, Timothy Edwards, Peter Elton, Julie Foster, Melanie Greaves, Graham Hayler, Coral Higgins, John Howells, Klaus Irion, Devinda Karunaratne, Jodie Kelly, Zoe King, Sarah Manson, Stuart Mellor, Donna Miller, Amanda Myerscough, Tom Newton, Michelle O'Leary, Rachel Pearson, Julie Pickford, Richard Sawyer, Nick J Screaton, Anna Sharman, Maggi Simmons, Elaine Smith, Ben Taylor, Sarah Taylor, Anna Walsham, Angela Watts, James Whittaker, Laura Yarnell, Anthony Threlfall, Phil V Barber, Janet Tonge, Richard Booton
We report baseline results of a community-based, targeted, low-dose CT (LDCT) lung cancer screening pilot in deprived areas of Manchester. Ever smokers, aged 55-74 years, were invited to 'lung health checks' (LHCs) next to local shopping centres, with immediate access to LDCT for those at high risk (6-year risk ≥1.51%, PLCO M2012 calculator). 75% of attendees (n=1893/2541) were ranked in the lowest deprivation quintile; 56% were high risk and of 1384 individuals screened, 3% (95% CI 2.3% to 4.1%) had lung cancer (80% early stage) of whom 65% had surgical resection...
February 13, 2018: Thorax
Michael D Manson
Like all living organisms, bacteria must communicate with the world around them. As they typically live as single cells, the communication with their environment must occur at the cell membrane, both in moving molecules in and out and in transmitting information about their surroundings to response elements within the cell. This volume is devoted primarily to methods used to study either the behavior of bacteria in response to their environment or methods used to study events that involve signaling pathways that are initiated by events at the cell membrane...
2018: Methods in Molecular Biology
Michael D Manson
Bacteria have a continuous and urgent need to inform themselves about the chemistry of their surroundings. They must rapidly adjust their patterns of gene expression, their metabolic and transport functions, and their behavior to cope with every challenge and opportunity with which they are presented. This volume collates the most recent methods developed to monitor and manipulate the processes by which bacteria sense and respond to their chemical environment.
2018: Methods in Molecular Biology
Deepika R Laddu, Betsy C Wertheim, David O Garcia, Nancy F Woods, Michael J LaMonte, Bertha Chen, Hoda Anton-Culver, Oleg Zaslavsky, Jane A Cauley, Rowan Chlebowski, JoAnn E Manson, Cynthia A Thomson, Marcia L Stefanick
OBJECTIVES: To compare the value of clinically measured gait speed with that of the self-reported Medical Outcomes Study 36-item Short-Form Survey Physical Function Index (SF-36 PF) in predicting future preclinical mobility disability (PCMD) in older women. DESIGN: Prospective cohort study. SETTING: Forty clinical centers in the United States. PARTICIPANTS: Women aged 65 to 79 enrolled in the Women's Health Initiative Clinical Trials with gait speed and SF-36 assessed at baseline (1993-1998) and follow-up Years 1, 3, and 6 (N = 3,587)...
February 10, 2018: Journal of the American Geriatrics Society
Pinkal Desai, Robert Wallace, Matthew L Anderson, Barbara V Howard, Roberta M Ray, Chunyuan Wu, Monika Safford, Lisa W Martin, Thomas Rohan, JoAnn E Manson, Michael S Simon
BACKGROUND: Statins have anti proliferative activity in vitro against endometrial and ovarian cancer and can affect levels of reproductive hormones. We analyzed data from the Women's Health Initiative (WHI) to assess whether statins are associated with risk of endometrial and ovarian cancer. METHODS: The WHI study included 161,808 postmenopausal women in which incident cases of endometrial (n = 1377) and ovarian cancer (n = 763) were identified over an average of 10...
February 5, 2018: Gynecologic Oncology
Denis Guedes Jogas
The article investigates the process of circulation of knowledge which occurred during the first decades of the twentieth century between the South American researchers Edmundo Escomel (Peru) and Alfredo Da Matta (Brazil) and the Europeans Alphonse Laveran (France) and Patrick Manson (England) with regard to the definition and validation of espundia as a disease specific to South America, while simultaneously the need to insert this illness into the newly created group of diseases called the "leishmaniasis" was proposed...
October 2017: História, Ciências, Saúde—Manguinhos
Catherine M Donlon, Meryl S LeBoff, Sharon H Chou, Nancy R Cook, Trisha Copeland, Julie E Buring, Vadim Bubes, Gregory Kotler, JoAnn E Manson
Vitamin D supplements are often used to benefit skeletal health, although data on effects of daily high-dose vitamin D alone on bone density and structure are lacking. The ongoing VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, randomized, placebo-controlled trial testing effects of high-dose supplemental vitamin D3 (cholecalciferol; 2000 IU/day) and/or omega-3 fatty acids (FAs; 1 g/day) for the primary prevention of cancer and cardiovascular disease. The study has a mean treatment period of 5 years among 25,874 U...
February 2, 2018: Contemporary Clinical Trials
Kuo-Ming Yu, Johnson Yiu-Nam Lau, Manson Fok, Yuk-Keung Yeung, Siu-Ping Fok, Felix Shek, Wing-Tak Wong, Qui-Lim Choo
Current source of recombinant human interleukin-11 (rhIL-11) is isolated from a fusion protein expressed by E. coli that requires additional enterokinase to remove linked protein, resulting in product heterogeneity of N-terminal sequence. Due to lack of glycosylation, rhIL-11 is suitable to be expressed by yeast cells. However, the only available yeast-derived rhIL-11 presents an obstacle in low production yield, as well as an unamiable process, such as the use of reverse-phase chromatography employing plenty of toxic organic solvents...
February 2, 2018: Protein Expression and Purification
Kuo-Ming Yu, Johnson Yiu-Nam Lau, Manson Fok, Yuk-Keung Yeung, Siu-Ping Fok, Suxing Zhang, Peizhen Ye, Kezhi Zhang, Xiaobo Li, Juan Li, Qin Xu, Wing-Tak Wong, Qui-Lim Choo
The mono-PEGylated recombinant human interleukin-11 (rhIL-11) was evaluated for its pharmacology and toxicology profile in non-human primates. This PEGylated IL-11 (PEG-IL11) showed a much prolonged circulating half-life of 67h in cynomolgus monkeys as compared to its un-PEGylated counterpart (~3h) through subcutaneous administration, implicating that a single injection of the recommended dose will effectively enhance thrombopoiesis in humans for a much longer period of time compared to rhIL-11 in humans (t1/2=6...
February 2, 2018: Toxicology and Applied Pharmacology
JoAnn E Manson, Shari S Bassuk
No abstract text is available yet for this article.
February 5, 2018: JAMA: the Journal of the American Medical Association
James Paul Hovis, Ryan Montalvo, Dimitrius Marinos, Manjari Joshi, Mark Shirtliff, Theodore T Manson, Robert V O'Toole
OBJECTIVES: To evaluate the effectiveness of intraoperative vancomycin powder in prevention of surgical site infection and biofilm formation on implants in a contaminated animal fixation model. METHODS: We created a rabbit surgical model including fixation implants at a tibial surgical site seeded with methicillin-resistant Staphylococcus aureus. Our study cohort included 18 rabbits. Nine received vancomycin powder at the surgical site, and the other 9 did not. Serum vancomycin levels were measured at scheduled time points over 24 hours...
January 30, 2018: Journal of Orthopaedic Trauma
Tesa M Severson, Yongsoo Kim, Stacey E P Joosten, Karianne Schuurman, Petra van der Groep, Cathy B Moelans, Natalie D Ter Hoeve, Quirine F Manson, John W Martens, Carolien H M van Deurzen, Ellis Barbe, Ingrid Hedenfalk, Peter Bult, Vincent T H B M Smit, Sabine C Linn, Paul J van Diest, Lodewyk Wessels, Wilbert Zwart
Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart, most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha (ERα), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor (GR) in this understudied tumor type remains wholly unexamined. This study reveals genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here in the context of MBC, in relation to the female disease and patient outcome...
February 2, 2018: Nature Communications
Nancy B Y Tsui, Gregory Cheng, Teresa Chung, Christopher W K Lam, Anita Yee, Peter K C Chung, Tsz-Ki Kwan, Elaine Ko, Daihai He, Wing-Tak Wong, Johnson Y N Lau, Lok Ting Lau, Manson Fok
The genetic bases of many common diseases have been identified through genome-wide association studies in the past decade. However, the application of this approach on public healthcare planning has not been well established. Using Macau with population of around 650,000 as a basis, we conducted a pilot study to evaluate the feasibility of population genomic research and its potential on public health decisions. By performing genome-wide SNP genotyping of over a thousand Macau individuals, we evaluated the population genetic risk profiles of 47 non-communicable diseases and traits, as well as two traits associated with influenza infection...
January 30, 2018: Scientific Reports
Yael Swica, Michelle P Warren, JoAnn E Manson, Aaron K Aragaki, Shari S Bassuk, Daichi Shimbo, Andrew Kaunitz, Jacques Rossouw, Marcia L Stefanick, Catherine R Womack
OBJECTIVE: The aim of the study was to determine the effect of menopausal hormone therapy on incident hypertension in the two Women's Health Initiative hormone therapy trials and in extended postintervention follow-up. METHODS: A total of 27,347 postmenopausal women aged 50 to 79 years were enrolled at 40 US centers. This analysis includes the subsample of 18,015 women who did not report hypertension at baseline and were not taking antihypertensive medication. Women with an intact uterus received conjugated equine estrogens (CEE; 0...
January 29, 2018: Menopause: the Journal of the North American Menopause Society
Serena C Houghton, JoAnn E Manson, Brian W Whitcomb, Susan E Hankinson, Lisa M Troy, Carol Bigelow, Elizabeth R Bertone-Johnson
BACKGROUND/OBJECTIVES: Women with premenstrual syndrome (PMS) are encouraged to reduce sugar and increase fiber intake to reduce symptoms. However, research supporting these recommendations is limited, and their role in PMS development is unclear. This study examines the relation between carbohydrate and fiber intake and the risk of PMS nested within the prospective Nurses' Health Study II cohort. SUBJECTS/METHODS: Carbohydrate and fiber intake were assessed at baseline and three additional times during follow up by food frequency questionnaire...
January 29, 2018: European Journal of Clinical Nutrition
Manson Cheuk-Man Fong, Nga Yan Hui, Edith Sze Wan Fung, Patrick Chun Kau Chu, William Shi-Yuan Wang
The N2 component is a well-known neural correlate of conflict monitoring (CM), being more negative in the presence of conflicting information in visual conflict tasks. However, whether to-be-ignored auditory distractors can introduce additional conflict remains unknown. In the present work, subjects performed a visual (V) and audiovisual (AV) version of a Go/NoGo flanker task, and responded only if the target arrow pointed toward a pre-specified direction (e.g., left). In the AV task, in which to-be-ignored auditory distractors that were semantically associated with the flankers were concurrently presented, the congruency effect on both RT and N2 amplitude were enhanced, confirming that additional conflict can be brought about by cross-modal distractors at both behavioural and neural levels...
January 20, 2018: Neuroscience Letters
G Manson, R Houot
Improved understanding of the interactions between cancer cells and the immune system combined with technological advances has led to the development of novel types of immunotherapies. These include checkpoint inhibitors (CPI), T cell engager antibodies (TCE), and Chimeric Antigen Receptor (CAR)-T cells which have demonstrated remarkable efficacy in B-cell malignancies, including anti-PD1 antibodies in Hodgkin lymphoma, and TCE and CAR-T cells in B-ALL, leading to their approval in these indications. Recent clinical data suggest that these immunotherapies may also benefit patients with other types of hematologic malignancies, particularly patients with Hodgkin and non-Hodgkin lymphomas...
January 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Pierpaolo Mincarone, Carlo Giacomo Leo, Maria Del Mar Trujillo-Martín, Jan Manson, Roberto Guarino, Giuseppe Ponzini, Saverio Sabina
Purpose: The importance of working toward quality improvement in healthcare implies an increasing interest in analysing, understanding and optimizing process logic and sequences of activities embedded in healthcare processes. Their graphical representation promotes faster learning, higher retention and better compliance. The study identifies standardized graphical languages and notations applied to patient care processes and investigates their usefulness in the healthcare setting. Data sources: Peer-reviewed literature up to 19 May 2016...
January 16, 2018: International Journal for Quality in Health Care
Michael S Simon, Jennifer L Beebe-Dimmer, Theresa A Hastert, JoAnn E Manson, Elizabeth M Cespedes Feliciano, Marian L Neuhouser, Gloria Y F Ho, Jo L Freudenheim, Howard Strickler, Julie Ruterbusch, Ana Barac, Rowan Chlebowski, Bette Caan
BACKGROUND: Few studies have examined the relationship between cardiometabolic risk factors linked to metabolic syndrome and mortality among women with breast cancer. METHODS: We used the Women's Health Initiative to evaluate the relationship between cardiometabolic risk factors, including waist circumference (WC), blood pressure, cholesterol level, and presence of type 2 diabetes, and their relation with death from breast cancer, cardiovascular disease (CVD), and other causes among 8641 women with local or regional stage invasive breast cancer...
January 16, 2018: Cancer
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