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Syed Hidayathulla, Abdelaaty A Shahat, Mansour S Alsaid, Abdullah A Al-Mishari
The present study investigates the optimization of tannase production from A. nidulans for various physicochemical parameters and harvests tannase for its chemical characterization. The maximum tannase activity was observed on the third day of incubation at 35°C and the stability was observed at pH 5.5 to 6.0 by holding its 100% activity. The tannase was partially purified from A. nidulans [FT10] by ammonium sulfate precipitation at different concentrations and it was found that at 80% of ammonium sulfate concentration, the precipitate exhibited the maximum activity for tannase of 96 U/ml...
February 26, 2018: FEMS Microbiology Letters
Mostafa M Ghorab, Mansour S Alsaid, Aiten M Soliman, Abdullah A Al-Mishari
Targeting EGFR has proven to be beneficial in the treatment of several types of solid tumours. So, a series of novel 2-(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-ylthio)-N-substituted acetamide 5-19 were synthesised from the starting material 4-(2-mercapto-4-oxobenzo[g]quinazolin-3(4H)-yl) benzenesulfonamide 4, to be evaluated as dual EGFR/HER2 inhibitors. The target compounds 5-19, were screened for their cytotoxic activity against A549 lung cancer cell line. The percentage inhibition of EGFR enzyme was measured and compared with erlotinib as the reference drug...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
Mansour S Alsaid, Abdullah A Al-Mishari, Aiten M Soliman, Fatma A Ragab, Mostafa M Ghorab
An array of some new N-(substituted)-2-((4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-yl)thio)acetamide 5-19 were synthesized from the starting compound 4-(2-mercapto-4-oxobenzo[g]quinazolin-3(4H)-yl)benzenesulfonamide 4, to be assessed for their cytotoxic activity against A549 lung cancer cell line and to determine their inhibitory effect on EGFR tyrosine kinase enzyme. Compounds 5-19 showed high activity towards A549 cell line with IC50 values of 0.12-8.70 μM. Compounds 6, 12 and 18 were the most potent in this series...
December 1, 2017: European Journal of Medicinal Chemistry
Abdelaaty A Shahat, Elsayed A Mahmoud, Abdullah A Al-Mishari, Mansour S Alsaid
BACKGROUND: Several edible plants are used in Kingdom of Saudi Arabia since early time to control microbial infections. In the present study, twenty-four Saudi Arabian medicinal plants d according to traditionally used were select and investigated for the antimicrobial activities. MATERIALS AND METHODS: This study was designed at evaluating the antimicrobial activities of the methanol extracts of twenty-four species of sixteen plant families used in the traditional medicine by Saudi Arabian people for the treatment of numerous ailments of the microbial and non-microbial origin against four Gram-positive, four Gram-negative bacteria and four fungi and yeast using the agar well diffusion method...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
Mostafa Mohammed Ghorab, Mansour Sulaiman Alsaid, Yassin Mohammed Nissan, Abdelkader Elbadawy Ashour, Abdullah Abdulalrahman Al-Mishari, Ashok Kumar, Sheikh Fayaz Ahmed
Novel sulfonamides 3-19 with a biologically active 3,4-dimethoxyphenyl moiety were designed and synthesized. The structures of the synthesized compounds were established using elemental analyses, IR, (1)H-NMR, (13)C-NMR spectral data and mass spectroscopy. All the synthesized compounds were evaluated for their in vitro anticancer activity against four cancer cell lines, namely human hepatocellular carcinoma (HepG2), human medulloblastoma (Daoy), human cervical cancer (HeLa), and human colon cancer (HT-29), by using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and dasatinib as the reference drug...
2016: Chemical & Pharmaceutical Bulletin
Mostafa M Ghorab, Mansour S Alsaid, Mohammed S Al-Dosari, Fatma A Ragab, Abdullah A Al-Mishari, Abdulaziz N Almoqbil
As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6-20, acrylamide 21, thiazolidine 22, thiazoles 23-29 and thiophenes 33-35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (34), 1,2-dihydroisoquinoline-7-carbonitrile (7), 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide (35), 1,2-dihydroisoquinoline-7-carbonitrile (6), 2-cyano-3-(dimethylamino)-N-(quinolin-3-yl)acrylamide (21), 1,2-dihydroisoquinoline-7-carbonitriles (11) and (8) exhibited higher activity (IC50 values of 27-45 μmol L-1) compared to doxorubicin (IC50 47...
June 1, 2016: Acta Pharmaceutica
Mostafa M Ghorab, Mansour S Alsaid, Mohammed S Al-Dosari, Yassin M Nissan, Abdullah A Al-Mishari
BACKGROUND: Quinoline derivatives have diverse biological activities including anticancer activity. On the other hand, many sulfonamide derivatives exhibited good cytotoxic activity. Hybrids of both moieties may present novel anticancer agents. RESULTS: Chloroquinoline incorporating a biologically active benzene-sulfonamide moieties 5-21 and diarylsulfone derivatives 22 and 23 were prepared using (E)-1-(4-((E)-7-chloro-1-methylquinolin-4(1H)-ylideneamino)phenyl)-3-(dimethyl-amino)prop-2-en-1-one 4 as strategic starting material...
2016: Chemistry Central Journal
Mostafa M Ghorab, Mansour S Al-Said, Abdullah A Al-Mishari, Ching Kheng Quah, Hoong-Kun Fun
In the title compound, C(16)H(12)F(3)N(3)O(2)S·0.47C(2)H(5)OH·0.53CH(3)OH, the quinoline ring system is approximately planar, with a maximum deviation of 0.035 (3) Å, and makes a dihedral angle of 52.67 (9)° with the benzene ring. The F atoms of the -CF(3) group are disordered over two orientations, with refined site occupancies of 0.56 (2) and 0.44 (2). A single solvate site is occupied at random by ethanol or methanol, with refined site occupancies of 0.470 (6) and 0.530 (6), respectively...
August 1, 2012: Acta Crystallographica. Section E, Structure Reports Online
Mishari Mohammed Dahrab, G Robert Laroche
OBJECTIVE: Length measuring instruments are frequently used in ophthalmic surgery practice. For all subspecialties, calipers need to be accurate. This study was carried out to identify errors of calibration in ophthalmic calipers as a potential source of significant clinical errors. DESIGN: This study is a descriptive research. METHODS: All Castroviejo calipers free of any visible damage and available to the ophthalmic surgeons in the operating room suites of our 2 affiliated hospitals were included...
December 2011: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Lev A Zhivotovsky, Vita L Akhmetova, Sardana A Fedorova, Victoria V Zhirkova, Elza K Khusnutdinova
This work develops a reference STR database on the Volga-Ural population, Russia, comprised of 640 individuals that were sampled from eight ethnic groups (Finno-Ugric Mari, Mordva-Moksha, Mordva-Erzja, Komi-Permjak, and Udmurt, and Turkic-speaking Bashkir, Tatar-Mishary, and Chuvash) and typed with 10 autosomal STR markers: TH01, CSF1P0, FGA, vWA, D3S1358, TPOX, D16S539, D8S1179, D13S317, FES. The groups differentiate in allele frequencies, and therefore we computed theta-values between allele frequencies in each ethnic groups and those in the database as a measure of their differentiation...
September 2009: Forensic Science International. Genetics
Ayman Al Sulaiman, Ahmed Suliman, May Al Mishari, Aziza Al Sawadi, Tarek M Owaidah
Genetic screening is an important tool to control, minimize, and prevent genetic disorders. Saudi Arabia started the first national premarital screening (PMS) program to control inherited hemoglobin (Hb) disorders that are the most commonly inherited genetic disorders in the Kingdom of Saudi Arabia. The aim of this study was to assess the knowledge, perception, and attitude among the Saudi population about the PMS program through a questionnaire-based survey. A total of 1,047 candidates were included, divided into three groups...
2008: Hemoglobin
Helal Sonbul, Mishari Al-Otaibi, Dowen Birkhed
OBJECTIVE: The aims of the study were: 1) to evaluate the caries profile in a group of Saudi adults with several dental restorations by assessing various caries-related factors using the Cariogram model, and 2) to correlate the Cariogram data, expressed as "the chance of avoiding caries", with initial caries lesions (DiS), total initial and manifest caries lesions (Di+mS), and filled surfaces (FS). MATERIAL AND METHODS: 175 individuals in Saudi Arabia, aged between 18 and 56 years, were included...
2008: Acta Odontologica Scandinavica
A M Abdel Gader, A A Al-Mishari, S A Awadalla, N M Buyuomi, T Khashoggi, M Al-Hakeem
OBJECTIVE: To clarify the role played by tissue factor pathway inhibitor (TFPI) in pregnancy hypertension. METHODS: Using enzyme-linked immunosorbent assays, hemostatic measurements were obtained for women with pre-eclampsia (n=51), nonproteinuric hypertension of pregnancy (n=62), postpartum pre-eclampsia 24 h after childbirth (n=31), and no hypertension (healthy pregnant controls, n=100). RESULTS: There was a significant increase in circulating free TFPI levels in women with pre-eclampsia (9...
December 2006: International Journal of Gynaecology and Obstetrics
Abdul Aziz A Al-Mishari, Abdel Galil M Abdel Gader, Abdul Wahab Al-Jabbari, Abdul Karim M Al-Momen, Mohamed O Gad El Rab, Zainab H Babay, Nasim Mahmoud
BACKGROUND: There is wide disagreement in the literature on the rate of detection of lupus anticoagulant (LA) in women with recurrent fetal loss (RFL). The aim of this study was to determine the prevalence of LA using four phospholipid-dependant coagulation tests in a large population of Saudi women. PATIENTS AND METHODS: We determined the prevalence of LA in women with RFL (n=925), normal pregnancy (n=663), and in healthy blood donors (n=204), at the King Khalid University Hospital, Riyadh...
November 2004: Annals of Saudi Medicine
Rafik Shalaby, Ahmed Desoky
The object of the present study was to assess the value and outcome of needlescopy in the treatment of inguinal hernia (IH) in 150 children operated upon in Al-Mishary Hospital, Riyadh, between October 1997 and October 1999. Their ages ranged between 6 and 96 months, (mean 61.6 +/- 28.32 months). There were 130 males and 20 females; 81 (54%) presented with a right-sided IH and among these patients a hidden contralateral hernia was diagnosed in 12 cases (8%). A left-sided IH was present in 30 (20%) bilateral IHs in 19 cases (12...
March 2002: Pediatric Surgery International
R Shalaby, A Arnos, A Desoky, A H Samaha
Patients and surgeons frequently opt for laparoscopic appendectomy for treatment of acute appendicitis. Clinical studies have shown this approach to be a reasonable alternative to open appendectomy. The objective of the current study was to assess the outcome of laparoscopic appendectomy using three different techniques. The study sample consisted of 150 children with acute appendicitis who underwent surgery at Al-Azhar University Hospitals, Cairo, Egypt, and at Al Mishary Hospital in Riyadh, Saudi Arabia, between October 1997 and October 1999...
February 2001: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
M A Al-Mishari
A clinical and bacteriological comparison of tetracycline and erythromycin was carried out in 40 patients with papulopustular acne vulgaris. Twenty patients received 250 mg of tetracycline BID and 20 received 250 mg of erythromycin BID for four months. Clinically, 19 (95%) of patients treated with tetracycline and 17 (85%) of those treated with erythromycin had improvement ranging from moderate to very good. Both drugs also reduced the microflora both in the pustules and on normal skin from the same patients...
1987: Clinical Therapeutics
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