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https://www.readbyqxmd.com/read/29679707/enhanced-delivery-of-fixed-dose-combination-of-synergistic-antichagasic-agents-posaconazole-benznidazole-based-on-amorphous-solid-dispersions
#1
Camila Bezerra Melo Figueirêdo, Daniela Nadvorny, Amanda Carla Quintas de Medeiros Vieira, Giovanna Christinne Rocha de Medeiros Schver, José Lamartine Soares Sobrinho, Pedro José Rolim Neto, Ping I Lee, Monica Felts de La Roca Soares
Posaconazole (PCZ) and benznidazole (BNZ) are known to show synergetic effect in treating the acute and chronic phases of Chagas disease, a neglected parasitic disease. However, as both compounds are poorly water soluble, the development of amorphous solid dispersions (ASDs) of a PCZ/BNZ fixed-dose combination in a water-soluble polymer becomes an attractive option to increase their apparent solubility and dissolution rate, potentially improving their oral bioavailability. The initial approach was to explore solvent evaporated solid dispertion (SD) systems for a PCZ/BNZ 50:50 (wt%) combination at several total drug loading levels (from SD with 10% to 50% drug loading) in water-soluble carriers, including polyvinylpyrrolidone (PVP K-30) and vinylpyrrolidone-vinyl acetate copolymer (PVPVA 64)...
April 18, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29677189/progress-in-the-pharmacological-treatment-of-human-cystic-and-alveolar-echinococcosis-compounds-and-therapeutic-targets
#2
Mar Siles-Lucas, Adriano Casulli, Roberto Cirilli, David Carmena
Human cystic and alveolar echinococcosis are helmintic zoonotic diseases caused by infections with the larval stages of the cestode parasites Echinococcus granulosus and E. multilocularis, respectively. Both diseases are progressive and chronic, and often fatal if left unattended for E. multilocularis. As a treatment approach, chemotherapy against these orphan and neglected diseases has been available for more than 40 years. However, drug options were limited to the benzimidazoles albendazole and mebendazole, the only chemical compounds currently licensed for treatment in humans...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29673703/snake-venoms-from-angola-intra-specific-variations-and-immunogenicity
#3
Paula Regina Simões de Oliveira, Felipe Silva de França, Isadora Maria Villas Boas, Marisa Maria Teixeira da Rocha, Sávio Stefanini Sant'Anna, Maria de Lourdes Bastos, Denise V Tambourgi
Snakebite is a public health problem in many countries of world. These accidents are considered a Neglected Tropical Disease and are responsible for a high morbidity and mortality index in the South and Southeast Asia and Sub-Saharan Africa. Angolan snake venoms are poorly investigated and no specific antivenom against them is available in the country. Thus, the aim of this study was to evaluate biochemical and immunogenic properties of male and female venoms from Naja nigricollis, Bitis arietans and Bitis gabonica snakes...
April 16, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/29673144/serum-hepcidin-concentration-in-individuals-with-sickle-cell-anemia-basis-for-the-dietary-recommendation-of-iron
#4
Juliana Omena, Cláudia Dos Santos Cople-Rodrigues, Jessyca Dias do Amaral Cardoso, Andrea Ribeiro Soares, Marcos Kneip Fleury, Flávia Dos Santos Barbosa Brito, Josely Correa Koury, Marta Citelli
Dietary iron requirements in patients with sickle cell disease (SCD) remain unclear. SCD is a neglected hemoglobinopathy characterized by intense erythropoietic activity and anemia. Hepcidin is the hormone mainly responsible for iron homeostasis and intestinal absorption. Intense erythropoietic activity and anemia may reduce hepcidin transcription. By contrast, iron overload and inflammation may induce it. Studies on SCD have not evaluated the role of hepcidin in the presence and absence of iron overload. We aimed to compare serum hepcidin concentrations among individuals with sickle cell anemia, with or without iron overload, and those without the disease...
April 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29670860/relapsing-fevers-neglected-tick-borne-diseases
#5
REVIEW
Emilie Talagrand-Reboul, Pierre H Boyer, Sven Bergström, Laurence Vial, Nathalie Boulanger
Relapsing fever still remains a neglected disease and little is known on its reservoir, tick vector and physiopathology in the vertebrate host. The disease occurs in temperate as well as tropical countries. Relapsing fever borreliae are spirochaetes, members of the Borreliaceae family which also contain Lyme disease spirochaetes. They are mainly transmitted by Ornithodoros soft ticks, but some species are vectored by ixodid ticks. Traditionally a Borrelia species is associated with a specific vector in a particular geographical area...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29670340/the-design-and-evaluation-of-psychometric-properties-for-a-questionnaire-on-elderly-abuse-by-family-caregivers-among-older-adults-on-hemodialysis
#6
Amaneh Mahmoudian, Razieh Torabi Chafjiri, Atefeh Alipour, Abbas Shamsalinia, Fatemeh Ghaffari
Introduction: Older adults with chronic disease are more vulnerable to abuse. Early and accurate detection of the elderly abuse phenomenon can help identify health-promoting solutions for the elderly, their family, and society. The purpose of this study was to design and evaluate the psychometric properties of a questionnaire on elderly abuse by family caregivers among older adults on hemodialysis. Methods: Qualitative and quantitative research methodologies were used to develop the questionnaire...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29670206/heterogeneity-analysis-and-diagnosis-of-complex-diseases-based-on-deep-learning-method
#7
Xiong Li, Liyue Liu, Juan Zhou, Che Wang
Understanding genetic mechanism of complex diseases is a serious challenge. Existing methods often neglect the heterogeneity phenomenon of complex diseases, resulting in lack of power or low reproducibility. Addressing heterogeneity when detecting epistatic single nucleotide polymorphisms (SNPs) can enhance the power of association studies and improve prediction performance of complex diseases diagnosis. In this study, we propose a three-stage framework including epistasis detection, clustering and prediction to address both epistasis and heterogeneity of complex diseases based on deep learning method...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669889/molecular-preadaptation-to-antimony-resistance-in-leishmania-donovani-on-the-indian-subcontinent
#8
F Dumetz, B Cuypers, H Imamura, D Zander, E D'Haenens, I Maes, M A Domagalska, J Clos, J-C Dujardin, G De Muylder
Antimonials (Sb) were used for decades for chemotherapy of visceral leishmaniasis (VL). Now abandoned in the Indian subcontinent (ISC) because of Leishmania donovani resistance, this drug offers a unique model for understanding drug resistance dynamics. In a previous phylogenomic study, we found two distinct populations of L. donovani : the core group (CG) in the Gangetic plains and ISC1 in the Nepalese highlands. Sb resistance was only encountered within the CG, and a series of potential markers were identified...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29669503/evaluation-of-trypanocidal-and-antioxidant-activities-of-a-selected-series-of-3-amidocoumarins
#9
Mauricio Moncada-Basualto, Michel Lapier, Juan Diego Maya, Betty Matsuhiro, Claudio Olea-Azar, Giovanna L Delogu, Eugenio Uriarte, Lourdes Santana, Maria Joao Matose
BACKGROUND: Neglected diseases are becoming more prevalent due to globalization. This has inspired active research in the development of new drugs for the treatment of parasitic diseases such as Chagas disease. OBJECTIVES: With the aim of finding new trypanocidal agents, we report the in vitro evaluation of a new series of 3-amidocoumarins with or without hydroxyl substituents at position 4 of the coumarin ring. METHODS: Electrochemical and biological assays were performed in order to assess the antioxidant and trypanocidal potential of these compounds, and to better understand the mechanisms involved in their activity...
April 18, 2018: Medicinal Chemistry
https://www.readbyqxmd.com/read/29669396/discordance-between-population-impact-of-musculoskeletal-disorders-and-scientific-interest-a-bibliometric-study
#10
Anthony V Perruccio, Calvin Yip, J Denise Power, Mayilee Canizares, Elizabeth M Badley
OBJECTIVE: Musculoskeletal disorders (MSDs) are a leading cause of healthy years lost due to premature mortality and disability. Our objective was to investigate whether MSDs were commensurably represented within the published health literature. METHODS: MEDLINE bibliometric data were retrieved for 2016 and 2011. The 25 disease branches, including MSDs, were ranked according to published paper counts, proportion of all publications, and increase in publications from 2011 to 2016...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29668824/neglected-disease-neglected-populations-the-fight-against-cryptococcus-and-cryptococcosis
#11
Marcio L Rodrigues
No abstract text is available yet for this article.
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29666821/probiotics-for-the-control-of-helminth-zoonosis
#12
REVIEW
Abadi Amare Reda
This paper is a comprehensive, concise, and an up to date review about probiotics effect and mechanisms against helminth infections of zoonotic importance. Zoonoses are diseases that can be transmitted from animals to humans in a reversible way. Despite zoonotic helminth diseases being still a challenge to the public health and the agriculture industries globally, they were still neglected in both human and veterinary medicine. Moreover, the increasing emergence of anthelmintic drug resistance constitutes failures of most disease control strategies, alarming for a quest to new alternative control approaches...
2018: Journal of Veterinary Medicine
https://www.readbyqxmd.com/read/29666434/stable-transformation-of-babesia-bigemina-and-babesia-bovis-using-a-single-transfection-plasmid
#13
Marta G Silva, Donald P Knowles, Monica L Mazuz, Brian M Cooke, Carlos E Suarez
Babesia bigemina and Babesia bovis, are the two major causes of bovine babesiosis, a global neglected disease in need of improved methods of control. Here, we describe a shared method for the stable transfection of these two parasites using electroporation and blasticidin/blasticidin deaminase as a selectable marker. Stably transfected B. bigemina and B. bovis were obtained using a common transfection plasmid targeting the enhanced green fluorescent protein-BSD (egfp-bsd) fusion gene into the elongation factor-1α (ef-1α) locus of B...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665947/the-burden-of-multidrug-resistant-tuberculosis-in-children
#14
H E Jenkins, C M Yuen
BACKGROUND: Childhood tuberculosis (TB) has historically been neglected, although in recent years there has been increased focus on this problem. In particular, there have been two efforts to estimate the burden of pediatric multidrug-resistant TB (MDR-TB). METHODS: We review current estimates of the global incidence of pediatric MDR-TB disease. We then combine pediatric MDR-TB treatment data from the World Health Organization and recently published case fatality ratio estimates for children with TB to produce mortality estimates for children with MDR-TB...
May 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29665574/diagnostic-methods-to-detect-uterus-illnesses-in-mares
#15
Miguel Alejandro Silva Rua, Celia Raquel Quirino, Rachel Bittencourt Ribeiro, Eulogio Carlos Queiroz Carvalho, Maria de Lourdes Amaral Bernadino, Aylton Bartholazzi Junior, Luisa Fernanda Cipagalta, Marcus Antônio Pessanha Barreto
Uterine illnesses are the major problem in horse reproductive programs. The diagnosis of these pathologies is often neglected or does not provide enough information about the cause. The aim of this study was to evaluate different diagnoses to provide more accurate information about endometritis and the real endometrial profile at the beginning of a breeding season. Fifty-one mares with reproductive failure were evaluated. Two different uterine cytology diagnoses, culture of uterine flush material and biopsy assay, were performed...
April 9, 2018: Theriogenology
https://www.readbyqxmd.com/read/29663919/diagnosis-monitoring-and-control-of-schistosomiasis-an-update
#16
Yanqi Wu, Jiaqing Liu, Yifen Lin, Rennan Weng, Ran Chen, Jian Li, Zhiyue Lv
Schistosomiasis is a neglected disease of tropics and subtropics, which has been associated with illness and death of millions of people, especially children. Although, excessive use of anthelmintic drugs and improvement of sanitation procedures have been in practice, yet timely detection, and diagnosis of low-intensity infections, are of utmost importance for reducing morbidity and final elimination of the disease. The diagnosis methods, currently being used for schistosomiasis, have several limitations, hence warrant further investigations for development of novel detection methods with higher rapidity, reliability, and convenience...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29663875/heterocyclic-n-oxides-a-promising-class-of-agents-against-tuberculosis-malaria-and-neglected-tropical-diseases
#17
Guilherme Felipe Dos Santos Fernandes, Aline Renata Pavan, Jean Leandro Dos Santos
Heterocyclic N-oxides have emerged as promising agents against a number of diseases and disorders, especially infectious diseases. This review analyzes the emergence and development of this scaffold in the medicinal chemistry, focusing mainly on the discovery of new heterocyclic N-oxide compounds with potent activity against tuberculosis, malaria and neglected tropical diseases (i.e. leishmaniasis and Chagas disease). A number of heterocyclic N-oxide are described herein, nevertheless, the following chemical classes deserve to be highlighted due to the large number of reports in the literature about their promising pharmacological effects: furoxan, benzofuroxan, quinoxaline 1,4-di-N-oxide, indolone N-oxide and benzimidazole N-oxide...
April 17, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29663338/tackling-scabies-novel-agents-for-a-neglected-disease
#18
REVIEW
Hima Gopinath, Manju Aishwarya, Kaliaperumal Karthikeyan
The scabies mite, Sarcoptes scabiei var hominis, is an obligate ectoparasite of humans. It has been a source of distress for humanity since antiquity. The troublesome mite is emerging triumphant over current acaricidal agents with reports of emerging resistance and treatment failures. Scabies in endemic areas and crusted scabies offer additional management challenges. Exploration of indigenous plants and better understanding of mite biology and pathogenesis provide opportunities for the development of novel agents for this common pest...
April 16, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29662931/ulcerative-colitis-are-we-neglecting-its-progressive-character
#19
Paulo Massinha, Francisco Portela, Sara Campos, Gabriela Duque, Manuela Ferreira, Sofia Mendes, Ana Margarida Ferreira, Carlos Sofia, Luís Tomé
Introduction: Ulcerative colitis (UC) is a chronic disease but its progressive character, with structural damage, is insufficiently studied. Objectives: To analyze a group of patients without referral bias, regarding its clinical course, the morphological damage, and functional status. Methods: We evaluated UC patients diagnosed between January 1, 2000 and December 31, 2004, living in the direct referral area of the hospital and determined the medication use, colectomy rate, structural damage ("lead pipe," stenosis, pseudopolyps, fibrous bridges), and anorectal function (prospective evaluation with the Cleveland Clinic Incontinence Score [CCIS] and the Fecal Incontinence Quality of Life Scale)...
March 2018: GE Portuguese Journal of Gastroenterology
https://www.readbyqxmd.com/read/29658499/-the-impact-of-abuse-and-neglect-in-childhood-on-the-development-of-substance-use-disorders
#20
E A Katan
The review of literature over the last decade addresses the impact of childhood abuse and neglect on the further development of addictions and mental disorders. The results of the studies have been analyzed in the aspect of abuse, age and gender characteristics in childhood and variants of consequences: from neurodevelopment to behavioral disorders. Childhood abuse and neglect is associated with the higher risk of posttraumatic stress disorder, suicidal behavior and some psychiatric diseases. Attention is focused on the fact that adults with substance use disorders (SUDs) report higher rates of child abuse than adults without SUDs...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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