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https://www.readbyqxmd.com/read/29793094/effects-of-chronic-antipsychotic-drug-exposure-on-the-expression-of-translocator-protein-and-inflammatory-markers-in-rat-adipose-tissue
#1
Anita Calevro, Marie-Caroline Cotel, Sridhar Natesan, Michel Modo, Anthony C Vernon, Valeria Mondelli
The precise effect of antipsychotic drugs on either central or peripheral inflammation remains unclear. An important issue in this debate is to what extent the known peripheral metabolic effects of antipsychotics, including increased adiposity, may contribute to increased inflammation. Adipose tissue is known to contribute to the development of systemic inflammation, which can eventually lead to insulin resistance and metabolic dysregulation. As a first step to address this question, we evaluated whether chronic exposure to clinically comparable doses of haloperidol or olanzapine resulted in the immune activation of rat adipose tissue...
May 16, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29793047/transcript-profiling-of-salt-tolerant-tobacco-mutants-generated-via-mutation-breeding
#2
Özge Çelik, Aybüke Ekşioğlu, Enes Yağız Akdaş
The main aim of the study is to identify the genes differentially, predominantly or specifically expressed in salt tolerant tobacco mutants, improved from Akhisar 97 and İzmir Özbaş varieties via mutation breeding, with respect to unstressed control plants. Seven tobacco mutants which have different salt tolerance capacities were evaluated by Gene Fishing analysis. Under stress conditions differentially expressed 100 reproducible bands were identified (74 of up-regulated and 20 of down-regulated while 6 were unknown)...
May 21, 2018: Gene Expression Patterns: GEP
https://www.readbyqxmd.com/read/29792949/srnaome-and-transcriptome-analysis-provide-insight-into-chilling-response-of-cowpea-pods
#3
Jinhua Zuo, Yunxiang Wang, Benzhong Zhu, Yunbo Luo, Qing Wang, Lipu Gao
Cowpea is an important horticultural crop in tropical and subtropical areas of Asia, Africa, and Latin America, as well as parts of southern Europe and Central and South America. Chilling injury is a common physiological hazard of cowpea in cold chain logistics which reduce the cowpea pod's nutritional quality and product value. However, the molecular mechanism involved in chilling injury remains unclear in cowpea pods. RNA-Seq and sRNA-Seq technologies were employed to decipher the miRNAs and mRNAs expression profiles and their regulatory networks in cowpea pods involved in chilling stress...
May 21, 2018: Gene
https://www.readbyqxmd.com/read/29792813/metabolomics-reveals-the-molecular-mechanisms-of-copper-induced-cucumber-leaf-cucumis-sativus-senescence
#4
Lijuan Zhao, Yuxiong Huang, Kelly Paglia, Arpana Vaniya, Benjamin Wancewicz, Arturo A Keller
Excess copper may disturb plant photosynthesis and induce leaf senescence. The underlying toxicity mechanism is not well understood. Here, 3-week-old cucumber plants were foliar exposed to different copper concentrations (10, 100 and 500 mg/L) for a final dose of 0.21, 2.1 and 10 mg/plant, using CuSO4 as the Cu ion source for seven days, three times per day. Metabolomics quantified 149 primary and 79 secondary metabolites. A number of intermediates of the tricarboxylic acid (TCA) cycle were significantly down-regulated 1...
May 24, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29792309/metabolic-and-physiologic-imaging-biomarkers-of-the-tumor-microenvironment-predict-treatment-outcome-with-radiation-or-a-hypoxia-activated-prodrug-in-mice
#5
Shingo Matsumoto, Shun Kishimoto, Keita Saito, Yoichi Takakusagi, Jeeva P Munasinghe, Nallathamby Devasahayam, Charles Hart, Robert J Gillies, James B Mitchell, Murali C Krishna
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic niches that lead to treatment resistance. Therefore, studies of tumor oxygenation and metabolic profiling should contribute to improved treatment strategies. Here we define two imaging biomarkers that predict differences in tumor response to therapy: 1) partial oxygen pressure (pO2), measured by EPR imaging; and 2) [1-13C] pyruvate metabolism rate, measured by hyperpolarized 13C MRI. Three human PDAC xenografts with varying treatment sensitivity (Hs766t, MiaPaCa-2, and Su...
May 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29792192/detection-technologies-and-metabolic-profiling-of-bile-acids-a-comprehensive-review
#6
REVIEW
Yanan Liu, Zhihui Rong, Dong Xiang, Chengliang Zhang, Dong Liu
Bile acids (BAs) are important regulatory factors of life activities, which are involved in the regulation of glucose, lipid and energy metabolisms, and closely associated with intestinal hormones, microbiotas and energy balance. BAs abnormalities easily lead to inflammation and metabolic diseases, in turn, the progress of diseases could influence characteristics of BAs. Therefore, accurate detection of BAs contents is of great significance to disease prevention, diagnosis and treatment. At present, the most widely used enzymatic method in clinical practice is applicable to the detection of total bile acid (TBA)...
May 23, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29792171/embryonic-transcriptome-and-proteome-analyses-on-hepatic-lipid-metabolism-in-chickens-divergently-selected-for-abdominal-fat-content
#7
Wei Na, Yuan-Yuan Wu, Peng-Fei Gong, Chun-Yan Wu, Bo-Han Cheng, Yu-Xiang Wang, Ning Wang, Zhi-Qiang Du, Hui Li
BACKGROUND: In avian species, liver is the main site of de novo lipogenesis, and hepatic lipid metabolism relates closely to adipose fat deposition. Using our fat and lean chicken lines of striking differences in abdominal fat content, post-hatch lipid metabolism in both liver and adipose tissues has been studied extensively. However, whether molecular discrepancy for hepatic lipid metabolism exists in chicken embryos remains obscure. RESULTS: We performed transcriptome and proteome profiling on chicken livers at five embryonic stages (E7, E12, E14, E17 and E21) between the fat and lean chicken lines...
May 23, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29791572/is-lipid-accumulation-product-associated-with-an-atherogenic-lipoprotein-profile-in-brazilian-subjects
#8
Flavia De Conti Cartolano, Caroline Pappiani, Maria Camila Prupper de Freitas, Antonio M Figueiredo Neto, Antônio Augusto Ferreira Carioca, Nágila Raquel Teixeira Damasceno
BACKGROUND: Lipid accumulation product (LAP), a simple and low-cost tool, is a novel biomarker of central lipid accumulation and represents a potential surrogate marker for atherogenic lipoprotein profile. However, its association with lipoprotein subfractions has not been described in the literature. OBJECTIVE: To determine whether LAP index could be used as a marker of low- and high-density lipoprotein (LDL and HDL) size in Brazilian individuals. METHODS: This cross-sectional study included patients (n = 351) of both sexes and age between 30-74 years...
April 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29790809/characterization-of-in-vitro-and-in-vivo-metabolism-of-leelamine-using-liquid-chromatography-tandem-mass-spectrometry
#9
Riya Shrestha, Jung Jae Jo, DooHyun Lee, Taeho Lee, Sangkyu Lee
1. Leelamine is a diterpene compound found in the bark of pine trees and has garnered considerable interest owing to its potent anticancer properties. The aim of the present study was to investigate the metabolic profile of leelamine in human liver microsomes (HLMs) and mice using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 2. We found that leelamine undergoes only Phase I metabolism, which generates one metabolite that is mono-hydroxylated at the C9 carbon of the octahydrophenanthrene ring (M1) both in vitro and in vivo...
May 23, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/29790775/dental-periodontal-and-salivary-conditions-in-diabetic-children-associated-with-metabolic-control-variables-and-nutritional-plan-adherence
#10
C Y Díaz Rosas, E Cárdenas Vargas, J E Castañeda-Delgado, L A Aguilera-Galaviz, M C Aceves Medina
AIM: Diabetes mellitus is a chronic disease that has manifestations other than alterations in endocrine regulation or in metabolic pathways. Several diseases of the oral cavity have been associated with diabetes mellitus type 1 and 2 in young people according to their evolution. Scarce information exists regarding the role of diabetes and its association with the oral health status in paediatric diabetic patients. The aims of the study were to assess the quality of saliva, saliva acidogenicity, dental caries experience, fluorosis and periodontal status in diabetic patients and to evaluate their relationship with metabolic control variables and nutritional plan adherence...
June 2018: European Journal of Paediatric Dentistry: Official Journal of European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/29790679/the-influence-of-a-3-week-body-mass-reduction-program-on-the-metabolic-parameters-and-free-amino-acid-profiles-in-adult-polish-people-with-obesity
#11
Małgorzata Moszak, Agnieszka Klupczyńska, Alina Kanikowska, Zenon Kokot, Agnieszka Zawada, Małgorzata Grzymisławska, Marian Grzymisławski
BACKGROUND: Previous studies have showed differences in the amino acid (AA) composition in the plasma of people with obesity when compared to lean individuals, but the perturbations of AA concentrations in obesity and the dynamics of AA changes after weight loss is not fully understood. OBJECTIVES: The objective of the study was to evaluate the effect of a short-term weight reduction program on the metabolic status and plasma AA levels in individuals with obesity...
April 16, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790616/in-vitro-and-in-vivo-metabolic-profiles-of-fasiglifam-by-using-ultra-high-performance-liquid-chromatography-combined-with-q-exactive-orbitrap-tandem-mass-spectrometry
#12
Jin-Qi Li, Jia-Feng Wang, Jie Li, Shu-Han Zhang, Dan He, Rong-Sheng Tong, Shu-Ya She
RATIONALE: Fasiglifam is an orally available and selective partial agonist of hGPR40 receptor, which was unexpectedly terminated at phase III clinical trials due to its severe hepatotoxicity. To fully understand its mechanism of action, it is necessary to investigate the in vitro and in vivo metabolic profiles of fasiglifam. METHODS: For in vitro metabolism, fasiglifam was incubated with rat or human liver microsomes in the presence of NADPH, GSH and UDPGA for 60 min...
May 23, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29790428/multi-ethnic-sult1a1-copy-number-profiling-with-multiplex-ligation-dependent-probe-amplification
#13
Raymon Vijzelaar, Mariana R Botton, Lisette Stolk, Suparna Martis, Robert J Desnick, Stuart A Scott
AIM: To develop a SULT1A1 multiplex ligation-dependent probe amplification assay and to investigate multi-ethnic copy number variant frequencies. METHODS: A novel multiplex ligation-dependent probe amplification assay was developed and tested on 472 African-American, Asian, Caucasian, Hispanic and Ashkenazi Jewish individuals. RESULTS: The frequencies of atypical total copy number (i.e., greater or less than two) were 38.7% for Hispanics, 38...
May 23, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29789708/combined-genotyping-microbial-diversity-and-metabolite-profiling-studies-on-farmed-mytilus-spp-from-kiel-fjord
#14
Caroline Utermann, Delphine Parrot, Corinna Breusing, Heiko Stuckas, Tim Staufenberger, Martina Blümel, Antje Labes, Deniz Tasdemir
The blue mussel Mytilus is a popular food source with high economical value. Species of the M. edulis complex (M. edulis, M. galloprovincialis and M. trossulus) hybridise whenever their geographic ranges overlap posing difficulties to species discrimination, which is important for blue mussel aquaculture. The aim of this study was to determine the genetic structure of farmed blue mussels in Kiel Fjord. Microbial and metabolic profile patterns were studied to investigate a possible dependency on the genotype of the bivalves...
May 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29789538/salvanic-acid-b-inhibits-glycolysis-in-oral-squamous-cell-carcinoma-via-targeting-pi3k-akt-hif-1%C3%AE-signaling-pathway
#15
Jie Wei, Jun Wu, Wen Xu, Hong Nie, Ruiqing Zhou, Rui Wang, Yang Liu, Guoyao Tang, Jianyong Wu
Our previous study demonstrated a progressive glycolytic perturbation during the course of DMBA-induced hamster oral carcinogenesis, which was attenuated by salvianolic acid B (Sal-B) treatment along with decreased incidences of oral squamous cell carcinoma (OSCC) formation. It was proposed that metabolic modulation should be an additional mode of action attributable to Sal-B's anti-carcinogenic activity. However, the molecular mechanisms underlying Sal-B-induced metabolic modulation function remained elusive...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29789485/association-of-plasma-lipids-and-polar-metabolites-with-low-bone-mineral-density-in-singaporean-chinese-menopausal-women-a-pilot-study
#16
Diana Cabrera, Marlena Kruger, Frances M Wolber, Nicole C Roy, John J Totman, Christiani Jeyakumar Henry, David Cameron-Smith, Karl Fraser
The diagnosis of osteoporosis is mainly based on clinical examination and bone mineral density assessments. The present pilot study compares the plasma lipid and polar metabolite profiles in blood plasma of 95 Singaporean-Chinese (SC) menopausal women with normal and low bone mineral density (BMD) using an untargeted metabolomic approach. The primary finding of this study was the association between lipids and femoral neck BMD in SC menopausal women. Twelve lipids were identified to be associated with low BMD by the orthogonal partial least squares (OPLS) model...
May 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29789435/molecular-mechanisms-preventing-senescence-in-response-to-prolonged-darkness-in-a-desiccation-tolerant-plant
#17
Meriem Durgud, Saurabh Gupta, Ivan Ivanov, Amin Omidbakhshfard, Maria Benina, Saleh Alseekh, Nikola Staykov, Mareike Hauenstein, Paul Dijkwel, Stefan Hörtensteiner, Valentina Toneva, Yariv Brotman, Alisdair R Fernie, Bernd Mueller-Roeber, Tsanko Gechev
The desiccation-tolerant plant Haberlea rhodopensis can withstand months of darkness without any visible senescence. Here, we investigated the molecular mechanisms of this adaptation to prolonged (30 days) darkness and subsequent return to light. H. rhodopensis plants remained green and viable throughout the dark treatment. Transcriptomic analysis revealed that darkness regulated several transcription factor (TF) genes. Stress- and autophagy-related TFs such as ERF8, HSFA2b, RD26, TGA1, and WRKY33 were upregulated, while chloroplast- and flowering-related TFs such as ATH1, COL2, COL4, RL1, and PTAC7 were repressed...
May 22, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29789273/insulin-resistance-is-related-to-psychiatric-disorders-among-obese-children
#18
Deniz Özalp Kızılay, Şermin Yalın Sapmaz, Semra Şen, Yekta Özkan, Betül Ersoy
OBJECTIVE: The current study aimed to investigate psychiatric consequences of obesity (OBy) and the relationship between metabolic syndrome components and psychiatric disorders in children. Our secondaryaim was to elucidate which of the anthropometric parameters or metabolic components were most strongly associated with psychiatric disorders. METHODS: The study included 88 obese(OB)and overweight (OW) children with a body mass index (BMI) greater than 85th percentile...
May 23, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29789155/endocrine-and-metabolic-profile-of-peripubertal-standardbred-colts
#19
Robyn E Ellerbrock, Igor F Canisso, Fabio S Lima, Clifford F Shipley, Donald L Thompson, Alan J Conley, Kevin H Kline
The objectives of this study were to determine the concentrations of reproductive and metabolic hormones during the peripubertal period and to assess their relationship with testicular development and body fat deposition. Blood samples were collected from 23 healthy Standardbred colts every four weeks for twelve months. Colts were weighed monthly, and percent of body fat and testicular volume estimated by ultrasound. Onset of puberty was determined as the month when testosterone was two standard deviations above the previous mean...
May 14, 2018: Theriogenology
https://www.readbyqxmd.com/read/29788882/impact-of-drug-metabolism-pharmacokinetics-and-their-relevance-upon-taxus-based-drug-development
#20
Da-Cheng Hao, Guang-Bo Ge, Ping Wang, Ling Yang
Drug metabolism and pharmacokinetic (DMPK) studies of Taxus natural products, their semi-synthetic derivatives and analogs are indispensable in the optimization of lead compounds and clinical therapy. These studies can lead to development of new drug entities with improved absorption, distribution, metabolism, excretion and toxicity (ADME/T) profiles. To date, there have been no comprehensive reviews of the DMPK features of Taxus derived medicinal compounds.Natural and semi-synthetic taxanes may cause and could be affected by drug-drug interaction (DDI)...
May 22, 2018: Current Drug Metabolism
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