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https://www.readbyqxmd.com/read/29334747/-drug-induced-tendon-injury
#1
Štefan Alušík, Zoltán Paluch
Tendon injury belongs to the less known side effects of some drugs, reported until recently only for glucocorticoids and fluoroquinolones. To date, some other classes of drugs such as statins, aromatase inhibitors, anabolic steroids, potentially causing tendon injury, have been added to the list. The authors discuss the most common clinical presentations, diagnosis, and management as well as latest experimental data regarding this issue. The most often, the Achilles tendon is affected, however, nearly every tendon of the entire body may be affected...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29304958/editorial-commentary-proximal-hamstring-syndrome-another-pain-in-the-buttock
#2
EDITORIAL
Dean K Matsuda
Proximal hamstring injuries cause buttock pain and may result in significant weakness and sciatic neuralgia. Avulsion ruptures involving 2 or more tendons with >2-cm retraction may benefit from early open surgical repair. More chronic equivalents may benefit from Achilles allograft reconstruction. Chronic proximal hamstring syndrome causing posterior thigh and sit pain may occur from less severe, often repetitive injury to the proximal hamstring origin with secondary sciatic neuralgia from local adhesions or scar entrapment...
January 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29278683/rescue-plan-for-achilles-therapeutics-steering-the-fate-and-functions-of-stem-cells-in-tendon-wound-healing
#3
Magdalena Schneider, Peter Angele, Tero A H Järvinen, Denitsa Docheva
Due to the increasing age of our society and a rise in engagement of young people in extreme and/or competitive sports, both tendinopathies and tendon ruptures present a clinical and financial challenge. Tendon has limited natural healing capacity and often responds poorly to treatments, hence it requires prolonged rehabilitation in most cases. Till today, none of the therapeutic options has provided successful long-term solutions, meaning that repaired tendons do not recover their complete strength and functionality...
December 23, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29276600/atraumatic-bilateral-rupture-of-the-peroneus-brevis-tendon-in-recreational-sport-a-case-report
#4
Patric Scheidegger, Lukas Weisskopf, Anja Hirschmüller
Issue: Lower extremity tendon injuries often occur in physically active individuals. Most ruptures not involving great force are diagnosed in patients presenting underlying tendon degenerations. This also applies to patients taking medications because of a disease. We have observed several cases of bilateral Achilles tendon ruptures in patients who have been taking cortisone for a long period. We treated a healthy colleague (neurologist) in our clinic who sustained ruptures of the Achilles tendon on the left side (2012) and the peroneus brevis tendon on left side (2015) and right side (2016) after minimal traumata...
2017: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29273251/outcomes-and-complications-following-endoscopically-assisted-percutaneous-achilles-tendon-repair
#5
Chamnanni Rungprai, Phinit Phisitkul
PURPOSE: To review functional and clinical outcomes as well as complications in patients who underwent endoscopically assisted percutaneous Achilles tendon repair using 4-strand core suture configuration via a 6-portal technique. METHODS: A retrospective chart review with prospectively collected data was performed in 23 consecutive patients who underwent endoscopically assisted percutaneous Achilles tendon repair between 2008 and 2015. The minimum follow-up to be included in the study was 24 months...
December 19, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29249084/return-to-sport-in-athletes-with-midportion-achilles-tendinopathy-a-qualitative-systematic-review-regarding-definitions-and-criteria
#6
REVIEW
Bas Habets, Anke G van den Broek, Bionka M A Huisstede, Frank J G Backx, Robert E H van Cingel
BACKGROUND: Midportion Achilles tendinopathy (AT) can cause long-term absence from sports participation, and shows high recurrence rates. It is important that the decision to return to sport (RTS) is made carefully, based on sharply delimited criteria. Lack of a well-defined definition and criteria hampers the decision to RTS among athletes with AT, and impedes comparison of RTS rates between different studies. OBJECTIVE: The aim of this study was to systematically review the literature for definitions of, and criteria for, RTS in AT research...
December 16, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29241762/eltrombopag-for-advanced-myelodysplastic-syndromes-or-acute-myeloid-leukaemia-and-severe-thrombocytopenia-aspire-a-randomised-placebo-controlled-phase-2-trial
#7
Moshe Mittelman, Uwe Platzbecker, Boris Afanasyev, Sebastian Grosicki, Raymond S M Wong, Achilles Anagnostopoulos, Benjamin Brenner, Claudio Denzlinger, Giuseppe Rossi, Arnon Nagler, Regina Garcia-Delgado, Maria Socorro O Portella, Zewen Zhu, Dominik Selleslag
BACKGROUND: Thrombocytopenia is a life-threatening complication in patients with advanced myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). In this study (ASPIRE), we aimed to assess eltrombopag, an oral thrombopoietin receptor agonist, for thrombocytopenia (grade 4) treatment in adult patients with advanced MDS or AML. METHODS: ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomised, double-blind phase (parts 1 and 2, reported here) for 12 weeks, and an open-label extension (part 3)...
December 11, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29237355/cross-cultural-adaptation-of-the-victorian-institute-of-sports-assessment-achilles-visa-a-questionnaire-for-spanish-athletes
#8
Sergio Hernández-Sánchez, Emilio José Poveda-Pagán, Yasser Alakhdar, Maria Dolores Hidalgo-Montesinos, César Fernández-de-Las-Peñas, José L Arias-Buría
Study Design Clinical measurement study. Background Achilles tendinopathy is a prevalent sport-related injury. The Victorian Institute of Sports Assessment-Achilles (VISA-A) questionnaire is a widely-used patient-reported outcome to assess the severity of symptoms for this injury. Objective To adapt the VISA-A questionnaire into Spanish and to assess its psychometric properties. Methods Cross-cultural adaptation was conducted according to recommended guidelines. The Spanish VISA-A (VISA-A-Sp) questionnaire was administered to 210 subjects: 70 healthy students, 70 active at risk subjects (participating in running and jumping) and 70 patients with Achilles tendinopathy diagnosis...
December 13, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29228442/a-novel-boswellic-acids-delivery-form-casperome%C3%A2-in-the-management-of-musculoskeletal-disorders-a-review
#9
A Riva, P Allegrini, F Franceschi, S Togni, L Giacomelli, R Eggenhoffner
Standard pharmacological treatment of musculoskeletal conditions is often associated with relevant side effects. Botanical preparations endowed with a good tolerability profile, therefore, could have a role in the management of these disorders. Among different natural products, Boswellia serrata extracts have long been used for the treatment of musculoskeletal disorders, given their marked anti-inflammatory activity and their ability to promote tissue regeneration. However, standard preparations of Boswellia serrata show overall modest pharmacokinetic properties, a limitation which may ultimately lead to reduced efficacy...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228408/-biomechanical-evaluation-of-rehabilitation-after-surgical-repair-of-achilles-tendon-ruptures
#10
Marlene Mauch, Markus Ulrich, Xaver Kaelin, Bernhard Segesser, Jochen Paul
Background Muscles and tendons are subjected to a high level of stress in everyday life and sports. This often leads to injuries and is associated with training failure and reduced performance as well as with high costs for treatment and rehabilitation. Fast and successful treatment is therefore very important, both from an athletic and economic point of view. This study aims to demonstrate the relevance of biomechanical procedures for the objective monitoring of rehabilitation. At the same time, the results are to be used to establish progress and evaluation criteria for an efficient and controlled rehabilitation...
December 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29227562/crosstalk-between-substance-p-and-calcitonin-gene-related-peptide-during-heterotopic-ossification-in-murine-achilles-tendon
#11
Ceren Tuzmen, Kostas Verdelis, Lee Weiss, Phil Campbell
Heterotopic ossification (HO) is abnormal bone formation within soft tissue, usually predisposed by neurogenic or musculoskeletal trauma. Inflammation resulting from trauma is considered to be the main trigger for HO by eliciting changes within the injury site, including elevation of bone morphogenetic proteins (BMPs). Recent research, however, has also associated changes in sensory neuropeptide expression with HO. Substance P (SP) and calcitonin gene-related peptide (CGRP) are two of those neuropeptides that have been implicated with various aspects of HO, including regulation of inflammation and BMP signaling...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29209417/do-athletes-alter-their-running-mechanics-after-an-achilles-tendon-rupture
#12
Daniel Jandacka, Julia Freedman Silvernail, Jaroslav Uchytil, David Zahradnik, Roman Farana, Joseph Hamill
Background: Over the past thirty years, there has been dramatic increase in incidence of Achilles tendon rupture in the athletic population. The purpose of this study was to compare the lower extremity mechanics of Achilles tendon ruptured runners with healthy controls. Methods: The participants with a past history of an Achilles tendon repair (n = 11) and healthy control (n = 11) subgroups were matched on sex, age, type of regular physical activity, mass, height, footfall pattern and lateral dominancy...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29199267/high-frequency-color-doppler-ultrasound-in-diagnosis-treatment-and-rehabilitation-of-achilles-tendon-injury
#13
Wen Liu, Haiying Zhuang, Dazhang Shao, Liangliang Wang, Miao Shi
BACKGROUND This study evaluated the clinical application of high-frequency color Doppler ultrasonography (HFCDU) in the diagnosis, treatment, and rehabilitation of Achilles tendon injury. MATERIAL AND METHODS A total of 68 patients with suspected Achilles tendon injury were examined by HFCDU. There were 42 Achilles tendon injury patients who underwent surgery, and they were randomly divided into a routine treatment group (n=21) and a rehabilitation group (n=21). HFCDU was performed at weeks 1, 3, 6, and 9, and months 3, 6, 9, 12, and 24 after the operation...
December 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29181248/effect-of-heel-lifts-on-patellofemoral-joint-stress-during-running
#14
Zachary Mestelle, Thomas Kernozek, Kelly S Adkins, Jessica Miller, Naghmeh Gheidi
Background: Patellofemoral pain is a debilitating injury for many recreational runners. Excessive patellofemoral joint stress may be the underlying source of pain and interventions often focus on ways to reduce patellofemoral joint stress. Purpose: Heel lifts have been used as an intervention within Achilles tendon rehabilitation programs and to address leg length discrepancies. The purpose of this study was to examine the effect of running with heel lifts on patellofemoral joint stress, patellofemoral stress impulse, quadriceps force, step length, cadence, and other related kinematic and spatiotemporal variables...
October 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29166259/clinical-outcome-of-achilles-tendon-repair-using-viable-intact-cryopreserved-umbilical-tissue-versus-standard-of-case
#15
John Brandeisky, Dorothy H Kurtz Phelan
INTRODUCTION: Repair of acute Achilles tendon ruptures is complicated by the severity of the rupture, quality of the tendon, and length of the defect. The adjunct use of biologics (eg, viable umbilical tissue) may provide additional support and reduce postoperative inflammation, adhesions, and fibrosis. OBJECTIVE: The aim of this study is to review the outcomes of Achilles tendon rupture open repairs with viable cryopreserved umbilical tissue (vCUT) compared with patients treated with standard of care only...
November 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29154089/triple-achilles-tendon-rupture-case-report
#16
Amol Saxena, Deann Hofer
We present a case report with 1-year follow-up data of a 57-year-old male soccer referee who had sustained an acute triple Achilles tendon rupture injury during a game. His triple Achilles tendon rupture consisted of a rupture of the proximal watershed region, a rupture of the main body (mid-watershed area), and an avulsion-type rupture of insertional calcific tendinosis. The patient was treated surgically with primary repair of the tendon, including tenodesis with anchors. Postoperative treatment included non-weightbearing for 4 weeks and protected weightbearing until 10 weeks postoperative, followed by formal physical therapy, which incorporated an "antigravity" treadmill...
November 16, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29150470/platelet-rich-plasma-in-achilles-tendon-healing-2-path-2-trial-protocol-for-a-multicentre-participant-and-assessor-blinded-parallel-group-randomised-clinical-trial-comparing-platelet-rich-plasma-prp-injection-versus-placebo-injection-for-achilles-tendon-rupture
#17
Joseph Alsousou, David J Keene, Philippa A Hulley, Paul Harrison, Susan Wagland, Christopher Byrne, Michael Maia Schlüssel, Susan J Dutton, Sarah E Lamb, Keith Willett
BACKGROUND: Achilles tendon injuries give rise to substantial long-lasting morbidity and pose considerable challenges for clinicians and patients during the lengthy healing period. Current treatment strategies struggle to curb the burden of this injury on health systems and society due to lengthy rehabilitation, work absence and reinjury risk. Platelet-rich plasma (PRP) is an autologous preparation that has been shown to improve the mechanobiological properties of tendons in laboratory and animal studies...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137567/primary-repair-of-achilles-tendon-avulsions-presentation-of-a-novel-technique-and-its-comparison-with-suture-anchor-repair
#18
Çetin Işık, Mesut Tahta
PURPOSE: We aimed to present our novel technique in the surgical treatment of Achilles tendon avulsions and compare the clinical results of such technique with the repair method using suture anchors. METHODS: A retrospective study was made of patients with Achilles tendon sleeve avulsion and patients where distal portion of the tear prohibited primary repair, surgically treated between January 2009 and January 2013. Twenty-one patients who met the criteria were examined and called for final examination: 9 patients were treated with the novel technique (group 1) and 12 patients were treated with suture anchor repair (group 2)...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29135646/foot-structure-and-function-in-habitually-barefoot-and-shod-adolescents-in-kenya
#19
Herje Aibast, Paul Okutoyi, Timothy Sigei, Walter Adero, Danny Chemjor, Neford Ongaro, Noriyuki Fuku, Kenn Konstabel, Carol Clark, Daniel E Lieberman, Yannis Pitsiladis
Habitually barefoot (HB) children from the Kalenjin tribe of Kenya are known for their high physical activity levels. To date, there has been no comprehensive assessment of foot structure and function in these highly active and HB children/adolescents and link with overuse injuries. PURPOSE: The aim of this research is to assess foot structure, foot function, injury and physical activity levels in Kenyan children and adolescents who are HB compared with those who were habitually shod (HS)...
November 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29096208/changes-in-the-soleus-h-reflex-test-and-correlations-between-its-results-and-dynamic-magnetic-resonance-imaging-abnormalities-in-patients-with-hirayama-disease
#20
Chaojun Zheng, Yu Zhu, Feizhou Lu, Dongqing Zhu, Shuo Yang, Xiaosheng Ma, Xinlei Xia, Robert Weber, Jianyuan Jiang
OBJECTIVE: To investigate changes in soleus H-reflex tests in patients with Hirayama disease (HD) and to analyse correlations between these changes and forward-shifting of the cervical cord during neck flexion. METHODS: The amplitude of the soleus H-reflex with and without vibration on the Achilles tendon was recorded bilaterally in 81 HD patients and 34 controls to measure both the vibratory inhibition index (VII) and the Hmax/Mmax ratio. The maximum forward-shifting degree of cervical cord during neck flexion was measured using dynamic magnetic resonance imaging in all HD patients...
October 3, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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