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https://www.readbyqxmd.com/read/28542244/a-quantitative-label-free-analysis-of-the-extracellular-proteome-of-human-supraspinatus-tendon-reveals-damage-to-the-pericellular-and-elastic-fibre-niches-in-torn-and-aged-tissue
#1
Osnat Hakimi, Nicola Ternette, Richard Murphy, Benedikt M Kessler, Andrew Carr
Tears of the human supraspinatus tendon are common and often cause painful and debilitating loss of function. Progressive failure of the tendon leading to structural abnormality and tearing is accompanied by numerous cellular and extra-cellular matrix (ECM) changes in the tendon tissue. This proteomics study aimed to compare torn and aged rotator cuff tissue to young and healthy tissue, and provide the first ECM inventory of human supraspinatus tendon generated using label-free quantitative LC-MS/MS. Employing two digestion protocols (trypsin and elastase), we analysed grain-sized tendon supraspinatus biopsies from older patients with torn tendons and from healthy, young controls...
2017: PloS One
https://www.readbyqxmd.com/read/28540605/characteristics-of-rheumatoid-arthritis-patients-undergoing-reverse-shoulder-arthroplasty
#2
Julio J Jauregui, J Paul Hovis, S Ashfaq Hasan
The risks and complication profile of reverse total shoulder arthroplasty (RSA) in rheumatoid arthritis (RA) patients has yet to be clearly defined as most studies have small cohorts. Using a large inpatient database, the purpose on our study was to determine the overall demographics, hospitalization characteristics, and early complication rates in rheumatoid patients and compared these to rotator-cuff arthropathy patients without RA undergoing RSA. Utilizing United States Nationwide Inpatient Sample from 2010 to 2013, we evaluated a total of 919 RA RSA and compared them to 8097 patients without RA undergoing RSA...
May 24, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28538578/total-abdominal-wall-transplantation-an-anatomical-study-and-classification-system
#3
David Light, Neilendu Kundu, Risal Djohan, Cristiano Quintini, Namita Gandhi, Brian R Gastman, Richard Drake, Maria Siemionow, James E Zins
BACKGROUND: Candidates for multivisceral transplantation present with complex defects often beyond traditional reconstructive options. In this study, the authors describe a dissection technique for a total abdominal wall vascularized composite flap. In addition, the authors suggest a classification system for complex abdominal wall defects. METHODS: Forty fresh, cadaveric hemiabdomens were dissected, with care taken to preserve the iliofemoral, deep circumflex iliac, superficial circumflex iliac, deep inferior epigastric, and superficial inferior epigastric arteries and corresponding veins...
June 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28537759/imaging-evaluation-of-nonacute-shoulder-pain
#4
Michael J Tuite, Kirstin M Small
OBJECTIVE: A variety of radiographic views have been described in the literature for the initial imaging of nonacute shoulder pain. Multiple articles have also discussed the best next imaging test if radiographs do not show the diagnosis, especially the use of unenhanced MRI, MR arthrography, CT arthrography, and ultrasound. The purpose of this article is to examine the evidence for the most helpful radiographic views and the best imaging test after radiographs for different clinical presentations of chronic shoulder pain...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28536897/validation-of-myocardial-perfusion-quantification-by-dynamic-ct-in-an-ex-vivo-porcine-heart-model
#5
Gert Jan Pelgrim, Marco Das, Sjoerd van Tuijl, Marly van Assen, Frits W Prinzen, Marco Stijnen, Matthijs Oudkerk, Joachim E Wildberger, Rozemarijn Vliegenthart
To test the accuracy of quantification of myocardial perfusion imaging (MPI) using computed tomography (CT) in ex-vivo porcine models. Five isolated porcine hearts were perfused according to Langendorff. Hearts were perfused using retrograde flow through the aorta and blood flow, blood pressure and heart rate were monitored throughout the experiment. An inflatable cuff was placed around the circumflex (Cx) artery to create stenosis grades which were monitored using a pressure wire, analysing perfusion at several fractional flow reserve values of 1...
May 23, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28535557/endogenous-pain-facilitation-rather-than-inhibition-differs-between-people-with-chronic-fatigue-syndrome-multiple-sclerosis-and-controls-an-observational-study
#6
Simon M Collin, Jo Nijs, Mira Meeus, Andrea Polli, Barbara Willekens, Kelly Ickmans
BACKGROUND: Commonalities in the core symptoms of fatigue and cognitive dysfunction experienced by chronic fatigue syndrome (CFS, also known as ME) and multiple sclerosis (MS) patients have been described. Many CFS and MS patients also experience chronic pain, which has been attributed to central sensitization in both groups of patients. However, the characteristics of pain in CFS and MS patients have not been compared. OBJECTIVES: To compare experimental pain measurements in patients with CFS or MS and healthy controls...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28535553/differences-in-pain-processing-between-patients-with-chronic-low-back-pain-recurrent-low-back-pain-and-fibromyalgia
#7
Dorien Goubert, Lieven Danneels, Thomas Graven-Nielsen, Filip Descheemaeker, Mira Meeus
BACKGROUND: The impairment in musculoskeletal structures in patients with low back pain (LBP) is often disproportionate to their complaint. Therefore, the need arises for exploration of alternative mechanisms contributing to the origin and maintenance of non-specific LBP. The recent focus has been on central nervous system phenomena in LBP and the pathophysiological mechanisms underlying the various symptoms and characteristics of chronic pain. Knowledge concerning changes in pain processing in LBP remains ambiguous, partly due to the diversity in the LBP population...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28534670/a-long-preoperative-duration-of-symptoms-is-associated-with-worse-functional-outcomes-after-1-stage-arthroscopic-treatment-of-rotator-cuff-tears-with-shoulder-stiffness
#8
Yuzhou Chen, Shiyi Chen, Yang Qiao, Yunshen Ge, Hong Li, Jiwu Chen, Yinghui Hua, Yunxia Li
BACKGROUND: Rotator cuff tears with shoulder stiffness remain a difficult issue. Despite the reported satisfactory results of 1-stage surgery, little information is available regarding the factors that affect clinical outcomes. Purpose/Hypothesis: To evaluate the 1-stage arthroscopic treatment of rotator cuff tears with shoulder stiffness and to present the influence of duration of symptoms (DOS) on postoperative functional outcomes. The hypothesis was that a long preoperative DOS is related to worse functional outcomes...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28533100/effects-of-remote-ischaemic-conditioning-on-heart-rate-variability-and-cardiac-function-in-patients-with-mild-ischaemic-heart-failure
#9
Long Chen, Qianxing Zhou, Hong Jin, Kongbo Zhu, Hong Zhi, Zhongpu Chen, Genshan Ma
BACKGROUND: Cardioprotective effects of remote ischaemic conditioning (RIC) in the setting of ischaemic heart disease have been shown recently. But the effects of RIC on heart rate variability (HRV) and cardiac function in patients with stable ischaemic heart failure (IHF) are still unknown. METHODS: Fifty patients with stable IHF were enrolled and randomly divided into RIC group and control group. Remote ischaemic conditioning treatment was performed twice a day for six weeks...
May 3, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28532898/toughening-of-fibrous-scaffolds-by-mobile-mineral-deposits
#10
Justin Lipner, John J Boyle, Younan Xia, Victor Birman, Guy M Genin, Stavros Thomopoulos
Partially mineralized fibrous tissue situated between tendon and bone is believed to be tougher than either tendon or bone, possibly serving as a compliant, energy absorptive, protective barrier between the two. This tissue does not reform following surgical repair (e.g., rotator cuff tendon-to-bone re-attachment) and might be a factor in the poor outcomes following such surgeries. Towards our long-term goal of tissue engineered solutions to functional tendon-to-bone re-attachment, we tested the hypotheses that partially mineralized fibrous matrices can derive toughness from mobility of mineral along their fibers, and that in such cases toughness is maximized at levels of mineralization sufficiently low to allow substantial mobility...
May 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28532184/a-review-of-invasive-and-non-invasive-sensory-feedback-in-upper-limb-prostheses
#11
Pamela Svensson, Ulrika Wijk, Anders Björkman, Christian Antfolk
The constant challenge to restore sensory feedback in prosthetic hands has provided several research solutions, but virtually none has reached clinical fruition. A prosthetic hand with sensory feedback that closely imitates an intact hand and provides a natural feeling may induce the prosthetic hand to be included in the body image and also reinforces the control of the prosthesis. Areas covered: This review presents non-invasive sensory feedback systems such as mechanotactile, vibrotactile, electrotactile and combinational systems which combine the modalities; multi-haptic feedback...
May 22, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28530692/a-rat-friendly-modification-of-the-non-invasive-tail-cuff-to-record-blood-pressure
#12
Boris Lipták, Barbara Kaprinay, Zdenka Gáspárová
No abstract text is available yet for this article.
May 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28530504/functional-recovery-after-rotator-cuff-repair-the-role-of-biceps-surgery
#13
Bernardo Gialanella, Francesco Grossetti, Marina Mazza, Laura Danna, Laura Comini
CONTEXT: Surgical cuff repair is indicated in full-thickness rotator cuff tear when non-operative treatment fails. Surgical cuff repair can comprehend surgery of long head of the biceps when concomitant biceps pathology is present. However, the studies executed up to now do not have yet clearly defined if additional biceps surgery affects the shoulder functionality in patients who underwent rotator cuff repair. OBJECTIVE: The aim of this study is to verify if the concomitant biceps surgery prejudices the shoulder functionality during the short-term period in rotator cuff repair patients...
May 22, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28529030/use-of-platelet-rich-plasma-in-the-treatment-of-rotator-cuff-pathology-what-has-been-scientifically-proven
#14
I Miranda, E Sánchez-Alepuz, F J Lucas, V Carratalá, C A González-Jofre
PURPOSE: To analyze the current scientific and/or clinical evidence supporting the use of platelet-rich plasma (PRP) in the treatment of rotator cuff pathology. METHODS: After a systematic review in PubMed, studies assessing PRP efficacy in the treatment of rotator cuff pathology published since 2013 to date were identified. Data were grouped based on type of study (laboratory, clinical or meta-analysis); accordingly study design, pathology treated and clinical outcomes were summarized...
May 18, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28528758/comparison-of-arterial-blood-pressure-measurements-obtained-invasively-or-oscillometrically-using-a-datex-s-5-compact-monitor-in-anaesthetised-adult-horses
#15
Tyfane T Yamaoka, Derek Flaherty, Patricia Pawson, Marian Scott, Adam Auckburally
OBJECTIVE: To assess agreement between noninvasive blood pressure (NIBP) oscillometrically-derived values from a multiparameter monitor (Datex Ohmeda S/5 Compact) with those obtained by invasive blood pressure (IBP) measurement in anaesthetised horses undergoing elective surgery. STUDY DESIGN: Prospective clinical study. ANIMALS: A total of 40 healthy adult horses. METHODS: Horses were anaesthetised with various anaesthetic protocols (based on clinical requirements)...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28528385/instability-of-the-long-head-of-the-biceps-tendon-in-patients-with-rotator-cuff-tear-evaluation-on-magnetic-resonance-arthrography-of-the-shoulder-with-arthroscopic-correlation
#16
Yusuhn Kang, Joon Woo Lee, Joong Mo Ahn, Eugene Lee, Heung Sik Kang
OBJECTIVES: To evaluate the diagnostic value of MR arthrography (MRA) in diagnosing instability of the LHBT in patients with rotator cuff tendon tear. MATERIALS AND METHODS: The MR arthrograms of 101 patients were retrospectively reviewed and correlated with arthroscopic findings as the standard reference. Images were evaluated for (1) the integrity of the LHBT, (2) the position of the LHBT (subluxation/dislocation on axial images, inferior displacement on oblique sagittal image) and (3) the integrity of the biceps pulley (SGHL, supraspinatus and subscapularis tendon adjacent to the rotator interval)...
May 20, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28528351/the-influence-of-critical-shoulder-angle-on-secondary-rotator-cuff-insufficiency-following-shoulder-arthroplasty
#17
Simone Cerciello, Andrew Paul Monk, Enrico Visonà, Stefano Carbone, Thomas Bradley Edwards, Nicola Maffulli, Gilles Walch
INTRODUCTION: Secondary cuff failure after shoulder replacement is disabling and often requires additional surgery. Increased critical shoulder angle (CSA) has been found in patients with cuff tear compared to normal subjects. The interobserver reliability of the CSA and the relationship between CSA and symptomatic secondary cuff failure after shoulder replacement were investigated. MATERIALS AND METHODS: Nineteen patients with symptomatic cuff failure after anatomic shoulder replacement (mean FU 45 months) were compared to a control group of 29 patients showing no signs of symptomatic cuff failure (mean FU 105...
May 20, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28527190/tight-medial-knot-tying-may-increase-retearing-risk-after-transosseous-equivalent-repair-of-rotator-cuff-tendon
#18
Hirotaka Sano, Masako Tokunaga, Moriyuki Noguchi, Takashi Inawashiro, Taichi Irie, Hiroo Abe, A Toshimitsu Yokobori
BACKGROUND: Retearing mechanism after transosseous equivalent (TOE) rotator cuff repair has not been fully clarified yet. OBJECTIVE: The purposes of this study were to compare the stress distribution pattern in the tendon stump between knotted and knotless TOE repair and to investigate the role of suture tension applied during medial knot tying using a 3-dimensional finite element (3D-FE) method. METHODS: Both knotted and knotless TOE repairs were simulated on the 3D-FE human rotator cuff tear model...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28526996/improved-outcomes-with-arthroscopic-repair-of-partial-thickness-rotator-cuff-tears-a-systematic-review
#19
J Christoph Katthagen, Gabriella Bucci, Gilbert Moatshe, Dimitri S Tahal, Peter J Millett
PURPOSE: The optimum treatment strategy for the surgical management of partial-thickness rotator cuff tears (PTRCT) is evolving. In this study, two research questions were sought to be answered: "Does the repair technique for PTRCTs involving >50% of the tendon thickness have an effect on structural and functional outcomes of arthroscopic repair?" and "Is there a difference in outcomes of arthroscopically treated articular- and bursal-sided PTRCTs?". METHODS: A systematic review according to the PRISMA statement was conducted to identify all literature published reporting on outcomes of arthroscopic treatment of PTRCTs classified with the Ellman classification with minimum 2-year follow-up...
May 19, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28526423/pseudoparalysis-a-systematic-review-of-term-definitions-treatment-approaches-and-outcomes-of-management-techniques
#20
REVIEW
John M Tokish, Thomas C Alexander, Michael J Kissenberth, Richard J Hawkins
BACKGROUND: Pseudoparalysis remains one of the most challenging conditions in shoulder surgery. Long thought of as an unsolvable problem, recent advances in surgical techniques offer potential return of overhead motion in the setting of massive irreparable rotator cuff tears. This article summarizes the available literature including existing definitions and the results of different treatment approaches regarding range of motion, outcome scores, and reversal. METHODS: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a systematic review of the MEDLINE database, Cochrane database, Physiotherapy Evidence Database, and Google Scholar database was performed for studies that defined a preoperative shoulder group as having pseudoparalysis...
June 2017: Journal of Shoulder and Elbow Surgery
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