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https://www.readbyqxmd.com/read/29457828/dihydrodiosgenin-protects-against-experimental-acute-pancreatitis-and-associated-lung-injury-through-mitochondrial-protection-and-pi3k%C3%AE-akt-inhibition
#1
Yan Shen, Li Wen, Rui Zhang, Zeliang Wei, Na Shi, Qiuyang Xiong, Qing Xia, Zhihua Xing, Zhi Zeng, Hai Niu, Wen Huang
BACKGROUND AND PURPOSE: Acute pancreatitis (AP) is a painful and burdensome exocrine pancreatic disorder with no specific drug treatment. Diosgenyl saponin extracts from Dioscorea zingiberensis C. H. Wright were reported to protect against experimental models of AP and diosgenin or its derivatives have anti-inflammatory effects in various diseases. However, the effects of diosgenin and its spiroacetal ring opened analog dihydrodiosgenin (Dydio) have not yet been determined in AP. EXPERIMENTAL APPROACH: Various concentrations of diosgenin and Dydio were tested for sodium taurocholate hydrate (Tauro)-induced necrosis in freshly isolated murine pancreatic acinar cells...
February 19, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29457141/extrahepatic-toxicity-of-acetaminophen-critical-evaluation-of-the-evidence-and-proposed-mechanisms
#2
Stefanie Kennon-McGill, Mitchell R McGill
Research on acetaminophen (APAP) toxicity over the last several decades has focused on the pathophysiology of liver injury, but increasing attention is being paid to other known and possible adverse effects. It has been known for decades that APAP causes acute kidney injury, but confusion exists regarding prevalence, and the mechanisms have not been well investigated. More recently, a number of experimental, clinical and epidemiological studies have reported evidence for pulmonary, endocrine, neurological and neurodevelopmental toxicity, but the quality of evidence from those studies varies...
January 15, 2018: Journal of Clinical and Translational Research
https://www.readbyqxmd.com/read/29456748/wound-closure-expectations-after-fasciotomy-for-paediatric-compartment-syndrome
#3
E D Shirley, V Mai, K M Neal, G M Kiebzak
Purpose: Acute compartment syndrome often requires additional surgery to achieve wound closure. Little information exists regarding the expected number of surgeries, techniques and complications after closure in paediatric patients. Methods: A retrospective chart review identified patients treated for acute compartment syndrome at four hospitals over a ten-year period. The cause of injury, type of dressing, number of surgeries, type of closure and complications were recorded...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456444/pain-pattern-classification-and-directional-preference-are-associated-with-clinical-outcomes-for-patients-with-low-back-pain
#4
Richard Yarznbowicz, Minjing Tao, Alexa Owens, Matt Wlodarski, Jonathan Dolutan
Pain Pattern Classification (PPC) and Directional Preference (DP) have shown merit as reliable and predictable clinical solutions to help reduce the burden posed by low back pain (LBP). We conducted a prospective, observational cohort study to verify the association between PPC, DP, and clinical outcomes. We hypothesized that (1) patients who demonstrated DP Centralization (CEN) would have lower pain intensity and disability at follow-up than patients who demonstrated Non-DP Non-CEN, and (2) the prevalence of DP at first examination would be lowest for patients with chronic LBP and are greater than 65 years old...
February 2018: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/29456415/gastroenteritis-in-an-adult-female-revealing-hemolytic-uremic-syndrome-case-report
#5
Paulina Chinchilla-López, Vania Cruz-Ramón, Oscar Ramírez-Pérez, Nahum Méndez-Sánchez
Nowadays acute gastroenteritis infection caused by Escherichia coli ( E. coli ) O157:H7 is frequently associated with hemolytic uremic syndrome (HUS), which usually developed after prodromal diarrhea that is often bloody. The abdominal pain accompanied by failure kidney is a suspicious symptom to develop this disorder. Their pathological characteristic is vascular damage which manifested as arteriolar and capillary thrombosis with abnormalities in the endothelium and vessel walls. The major etiological agent of HUS is enterohemorragic ( E coli ) strain belonging to serotype O157:H7...
February 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29456155/rheumatic-syndromes-and-occult-tumor-10-year-experience-in-a-teaching-hospital
#6
David Castro Corredor, Marco Aurelio Ramírez Huaranga, Ana Isabel Rebollo Giménez, Rocío Arenal López, José Luis Cuadra Díaz
OBJECTIVE: To describe the different clinical characteristics of patients admitted to the Rheumatology Department due to rheumatic manifestations as the first expression of an unknown malignant process. PATIENTS AND METHODS: Retrospective and descriptive observational study involving the review of the medical records of those admitted to rheumatology in the University Hospital of Ciudad Real between January 2007 and August 2017 for initial rheumatic manifestations with a suspicion at discharge of an unknown tumor...
February 15, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29455775/stress-cardiomyopathy-of-the-critically-ill-spectrum-of-secondary-global-probable-and-subclinical-forms
#7
REVIEW
Anand Chockalingam
Stress cardiomyopathy (SC) typically presents as potential acute coronary syndrome (ACS) in previously healthy people. While there may be physical or mental stressors, the initial symptom is usually chest pain. This form conforms to the published Mayo diagnostic criteria, is well reported and as the presentation is initially cardiac, is considered primary SC. Increasingly we see SC develop several days into the hospitalization secondary to medical or surgical critical illness. This condition is more complex, presents atypically, is not easy to recognize and carries a much worse prognosis...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29455544/heart-failure-affects-liver-morphology-and-function-what-are-the-clinical-implications
#8
E Goncalvesova, M Kovacova
Liver dysfunction in heart failure is common and usually clinically significant, especially in patients with advanced or severe acute heart failure. Lesions are caused by an impaired hepatic circulation due to congestion and hypoperfusion. Congestive lesions are more common and typically manifested by painful hepatomegaly and increased direct bilirubin and alkaline phosphatase. The inferior vena cava and hepatic veins are usually dilated. Congestive lesions are characterized by dilatation of the central vein with fibrotic changes in the surrounding areas on histological examination...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455120/amyand-s-hernia-with-acute-gangrenous-appendicitis-and-cecal-perforation-a-case-report-and-review-of-the-literature
#9
William Kromka, Aline S Rau, Charles J Fox
INTRODUCTION: An Amyand's hernia is a heterogeneous clinical condition defined by the presence of the vermiform appendix within an inguinal hernia sac, which may or may not contain other abdominal contents or pathologic inflammatory changes. Herein we present an exceptionally rare case of an Amyand's hernia containing acute appendicitis and a perforated cecum. PRESENTATION OF CASE: A 46-year-old male with a right inguinal hernia of 2-3 year duration presented to our Emergency Department complaining of acute onset abdominal and groin pain...
February 14, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29455018/acute-massive-pulmonary-thromboembolism-treated-by-selective-catheter-directed-thrombolysis
#10
Feng Hai, Chen Xueming, Zhang Zhiwen, Li Chenyu, Fang Jie, Zhang Zhe, Lian Lishan, Zhu Renming, Yu Hongzhi, Liu Bin
OBJECTIVE: To evaluate the safety and efficacy of selective catheter-directed thrombolysis in treating acute massive pulmonary thromboembolism (AMPTE). MATERIALS AND METHODS: Twenty-six AMPTE patients were enrolled between March 2010 and March 2013. A Uni*Fuse infusion system was inserted into the main pulmonary artery thrombus. The thrombolytic regimen included an intraoperative bolus injection of 250,000 IU urokinase, followed by continuous thrombolytic infusion of 5,000IU/kg...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29455017/thrombectomy-devices-in-the-treatment-of-acute-mesenteric-ischemia-initial-single-center-experience
#11
Bruno Freitas, Yvonne Bausback, Johannes Schuster, Matthias Ulrich, Sven Bräunlich, Andrej Schmidt, Dierk Scheinert
INTRODUCTION: To report our preliminary experience with endovascular revascularization of patients with acute mesenteric ischemia (AMI), using thrombectomy devices. MATERIAL AND METHODS: A retrospective analysis of patients admitted to our hospital due to AMI and who were subjected to concomitant or exclusive endovascular treatment, from January 2011 to January 2016. Patients were admitted at the emergency department, underwent imaging investigation and were referred to the endovascular specialist...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29455015/symptomatic-type-b-intramural-aortic-hematoma-as-a-complication-of-retrograde-right-common-iliac-artery-dissection
#12
Alessia Sonetto, Mauro Gargiulo, Enrico Gallitto, Stefano Ancetti, Gianluca Faggioli, Andrea Stella
PURPOSE: To report the endovascular treatment of a spontaneous iliac artery dissection (IAD) involving iliac bifurcation, complicated by a type B intramural aortic hematoma (IMH). CASE REPORT: A 38-year-old female patient came to our institution referring an acute ascending back pain. The angioCT-scan showed the presence of a retrograde right IAD with entry tear at the iliac bifurcation and a concomitant aortic IMH. After hypogastric embolization with a vascular plug, self-expanding stent-graft was placed to cover the iliac entry tear...
February 15, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29454958/clinical-features-and-surgical-management-of-cerebellopontine-angle-cholesteatoma-presented-as-trigeminal-neuralgia
#13
Ma Kai, Li Yongjie
BACKGROUND: It is difficult to differentiate patients with cerebellopontine angle (CPA) cholesteatoma and patients with primary trigeminal neuralgia(TN) just according to early symptoms. We aimed to explore the clinical characteristics, early diagnosis and microneurosurgical techniques for CPA cholesteatoma presented as trigeminal neuralgia. METHODS: The data of 26 patients who complained trigeminal neuralgia with cerebellopontine angle cholesteatoma between January 2009 and December 2015 were collected and studied retrospectively, they were diagnosed by MRI preoperatively and confirmed by pathology postoperatively...
February 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454329/bilateral-acute-angle-closure-glaucoma-following-tramadol-subcutaneous-administration
#14
Anis Mahmoud, Fatma Abid, Imen Ksiaa, Sourour Zina, Riadh Messaoud, Moncef Khairallah
BACKGROUND: To report a case of bilateral acute angle closure-glaucoma following the use of subcutaneous Tramadol. CASE PRESENTATION: A 42-year-old healthy man with unremarkable past medical and ocular history, was admitted to the Orthopedic Department for surgical treatment of a bilateral open fracture of the femur following a road accident. Three hoursafterTramadolsubcutaneous injection, the patient complained of a bilateral acute painful visual loss with persistent vomiting...
February 17, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29454129/delayed-post-traumatic-subacute-lumbar-subarachnoid-hematoma-case-report-and-review-of-the-literature
#15
Thiébaud Picart, Timothée Jacquesson, Emmanuel Jouanneau, Moncef Berhouma
BACKGROUND: Traumatic spinal subarachnoid hematoma, associated or not to a concurrent subdural hematoma has rarely been described. The evolution of such hematomas is heterogeneous. This study aims at defining the most accurate management which is currently not standardized. CASE DESCRIPTION: A 20-year-old man, victim of a high kinetic road accident five days before, suffering from several non-neurologic non-surgical vertebral fractures, complained of a sudden dorso-lumbar pain irradiating to his lower limbs...
February 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29454083/incidence-of-acute-suppurative-sialadenitis-in-end-stage-cancer-patients-a-retrospective-observational-study
#16
Hiroaki Watanabe, Takuya Odagiri, Yasuyuki Asai
CONTEXT: Acute suppurative sialadenitis (hereafter referred to as sialadenitis) is accompanied by pain and fever and can diminish the quality of life (QOL) in end-stage cancer patients; however, its incidence is not clear. OBJECTIVES: We conducted this study to elucidate the incidence of sialadenitis in end-stage cancer patients. METHODS: Retrospective review, observational study based on patients' medical records SUBJECTS: 726 consecutive cancer patients who died on the palliative care unit of our hospital between April 2012 and November 2016 were included...
February 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29453731/patient-perceptions-of-acute-pain-and-activity-disruption-following-inguinal-hernia-repair-a-propensity-matched-comparison-of-robotic-assisted-laparoscopic-and-open-approaches
#17
James G Bittner Iv, Lawrence W Cesnik, Thomas Kirwan, Laurie Wolf, Dongjing Guo
Few publications describe the potential benefit of robotic-assisted inguinal hernia repair on acute postoperative groin pain (APGP). This study compared patients' perceptions of APGP, activity limitation, and overall satisfaction after robotic-assisted- (R), laparoscopic (L), or open (O) inguinal hernia repair (IHR). Random samples of patients from two web-based research panels and surgical practices were screened for patients who underwent IHR between October 28, 2015 and November 1, 2016. Qualified patients were surveyed to assess perceived APGP at 1 week postoperatively, activity disruption, and overall satisfaction...
February 16, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29452920/patient-centered-medical-homes-did-not-improve-access-to-timely-follow-up-after-ed-visit
#18
Shih-Chuan Chou, Craig Rothenberg, Alicia Agnoli, Ilse Wiechers, Jason Lott, Jennifer Voorhees, Steven L Bernstein, Arjun K Venkatesh
BACKGROUND: Patients newly insured through coverage expansion under the Affordable Care Act (ACA) may have difficulty obtaining timely primary care follow-up appointments after emergency department (ED) discharge. We evaluated the association between availability of timely follow-up appointment with practice access improvements, including patient-centered medical home (PCMH) designations or extended-hours appointments. METHODS: We performed a secret-shopper audit of primary care practices in greater New Haven, Connecticut...
February 4, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29452881/tenosynovial-chondromatosis-of-the-wrist-presenting-with-acute-carpal-tunnel-syndrome-a-case-report
#19
L K Head, R Bradley, M Momtazi
We report a case of synovial chondromatosis of the wrist that manifested as acute carpal tunnel syndrome. The patient successfully underwent carpal tunnel release, tenosynovectomy and resection of dorsal and volar ossified bodies embedded in the tenosynovium overlying the wrist. Final histopathology confirmed the diagnosis of synovial chondromatosis. The patient's symptoms of pain, numbness, and paresthesia in a median nerve distribution resolved completely and the patient resumed full-time work in the service industry 4-weeks postoperatively with no functional limitations...
February 13, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29452690/utility-of-physician-selection-of-cardiac-tests-in-a-chest-pain-unit-to-exclude-acute-coronary-syndrome-among-patients-without-a-history-of-coronary-artery-disease
#20
Stacey J Howell, Jonathan Bui, Balasingam Thevakumar, Ezra A Amsterdam
There are few data on the utility of physician selection of cardiac tests, including no-test, in a chest pain unit (CPU) to rule out acute coronary syndrome in low-risk patients without a history of coronary artery disease. We analyzed consecutive low-risk patients admitted to our CPU between 2012 and 2014 and determined the proportion of patients selected for testing, the type of initial cardiac test selected, and the incidence of major adverse cardiac events (MACEs) at 30 days and 6 months. The study group comprised 619 patients: mean age 57 years (27 to 92), 332 women (54%), and 360 (58%) with multiple cardiac risk factors...
January 10, 2018: American Journal of Cardiology
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