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https://www.readbyqxmd.com/read/28733748/preoperative-botulinum-toxin-a-enabling-defect-closure-and-laparoscopic-repair-of-complex-ventral-hernia
#1
Omar Rodriguez-Acevedo, Kristen E Elstner, Anita S W Jacombs, John W Read, Rodrigo Tomazini Martins, Fernando Arduini, Michael Wehrhahm, Colette Craft, Peter H Cosman, Anthony N Dardano, Nabeel Ibrahim
INTRODUCTION: Operative management of complex ventral hernia still remains a significant challenge for surgeons. Closure of large defects in the unprepared abdomen has serious pathophysiological consequences due to chronic contraction and retraction of the lateral abdominal wall muscles. We report outcomes of 56 consecutive patients who had preoperative Botulinum toxin A (BTA) abdominal wall relaxation facilitating closure and repair. METHODS: This was a prospective observational study of 56 patients who underwent ultrasound-guided BTA into the lateral abdominal oblique muscles prior to elective ventral hernia repair between November 2012 and January 2017...
July 21, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28723242/interspecific-and-intraspecific-hybrid-epichlo%C3%A3-species-symbiotic-with-the-north-american-native-grass-poa-alsodes
#2
Tatsiana Shymanovich, Nikki D Charlton, Ashleigh M Musso, Jonathan Scheerer, Nadja B Cech, Stanley H Faeth, Carolyn A Young
The endophyte presence and diversity in natural populations of Poa alsodes were evaluated along a latitudinal transect from the southern distribution range in North Carolina to New York. Two distinct Epichloë hybrid taxa were identified from 23 populations. Each taxon could easily be distinguished by polymerase chain reaction (PCR) genotyping with primers designed to mating type genes and alkaloid biosynthesis genes that encode key pathway steps for ergot alkaloids, indole-diterpenes, lolines, and peramine...
June 26, 2017: Mycologia
https://www.readbyqxmd.com/read/28605977/linalool-induced-oxidative-stress-processes-in-the-human-pathogen-candida-albicans
#3
Gábor Máté, Dominika Kovács, Zoltán Gazdag, Miklós Pesti, Árpád Szántó
The present study investigated the linalool (Lol)-induced effects in acute toxicity tests in the human pathogen Candida albicans (C. albicans). Lol treatments induced reduced germ tube formation of the pathogen, which plays a crucial role in the virulence. In comparison with the untreated control, the exposure of 107 cells ml(-1) to 0.7 mM or 1.4 mM Lol for one hour induced 20% and 30% decrements, respectively, in the colony-forming ability. At the same time, these treatments caused dose-dependent decrease in the levels of superoxide anion radical and total reactive oxygen species, while there was 1...
June 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28597191/theoretical-analysis-of-the-binding-of-iron-iii-protoporphyrin-ix-to-4-methoxyacetophenone-thiosemicarbazone-via-dft-d3-mep-qtaim-nci-elf-and-lol-studies
#4
Nyiang Kennet Nkungli, Julius Numbonui Ghogomu
Thiosemicarbazones display diverse pharmacological properties, including antimalarial activities. Their pharmacological activities have been studied in depth, but little of this research has focused on their antimalarial mode of action. To elucidate this antimalarial mechanism, we investigated the nature of the interactions between iron(III) protoporphyrin IX (Fe(III)PPIX) and the thione-thiol tautomers of 4-methoxyacetophenone thiosemicarbazone (MAPTSC). Dispersion-corrected density functional theory (DFT-D3), the quantum theory of atoms in molecules (QTAIM), the noncovalent interaction (NCI) index, the electron localization function (ELF), the localized orbital locator (LOL), and thermodynamic calculations were employed in this work...
July 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/28556359/synthesis-solid-state-structure-and-bonding-analysis-of-a-homoleptic-beryllium-azide
#5
Dominik Naglav, Briac Tobey, Benjamin Lyhs, Beate Römer, Dieter Bläser, Christoph Wölper, Georg Jansen, Stephan Schulz
[Ph4 P]2 [Be(N3 )4 ] (1) and [PNP]2 [Be(N3 )4 ] (2; PNP=Ph3 PNPPh3 ) were synthesized by reacting Be(N3 )2 with [Ph4 P]N3 and [PNP]N3 . Compound 1 represents the first structurally characterized homoleptic beryllium azide. The electronic structure and bonding situation in the tetraazidoberyllate dianion [Be(N3 )4 ](2-) were investigated by quantum-chemical calculations (NPA, ELF, LOL).
May 29, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28554617/dynamic-controlled-atmosphere-dca-interaction-between-dca-methods-and-1-methylcyclopropene-on-fuji-suprema-apple-quality
#6
Anderson Weber, Fabio Rodrigo Thewes, Rogerio de Oliveira Anese, Vanderlei Both, Elizandra Pivotto Pavanello, Auri Brackmann
The objective of the present work was to evaluate the appropriate respiratory quotient (RQ) value to achieve a safe lowest oxygen limit (LOL), during storage of 'Fuji Suprema' apples, in dynamic controlled atmosphere (DCA), treated with or without 1-methylcyclopropene (1-MCP). The apples were stored in DCA-RQ, a new technology for storing fruits, and were compared with the HarvestWatch™, a system based on chlorophyll fluorescence DCA (DCA-CF), and static controlled atmosphere. DCA-RQ1.5 is the most suited for the storage of 'Fuji Suprema' apples...
November 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28451054/molecular-fingerprinting-of-complex-grass-allergoids-size-assessments-reveal-new-insights-in-epitope-repertoires-and-functional-capacities
#7
S Starchenka, A J Bell, J Mwange, M A Skinner, M D Heath
BACKGROUND: Subcutaneous allergen immunotherapy (SCIT) is a well-documented treatment for allergic disease which involves injections of native allergen or modified (allergoid) extracts. The use of allergoid vaccines is a growing sector of the allergy immunotherapy market, associated with shorter-course therapy. The aim of this study was the structural and immunological characterisation of group 1 (Lol p 1) IgG-binding epitopes within a complex mix grass allergoid formulation containing rye grass...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28288204/correction-linear-in-the-parameters-oblique-least-squares-lols-provides-more-accurate-estimates-of-density-dependent-survival
#8
Vasco M N C S Vieira, Aschwin H Engelen, Oscar R Huanel, Marie-Laure Guillemin
[This corrects the article DOI: 10.1371/journal.pone.0167418.].
2017: PloS One
https://www.readbyqxmd.com/read/28236469/treatment-with-grass-allergen-peptides-improves-symptoms-of-grass-pollen-induced-allergic-rhinoconjunctivitis
#9
Anne K Ellis, Charles W Frankish, Robyn E O'Hehir, Kristen Armstrong, Lisa Steacy, Mark Larché, Roderick P Hafner
BACKGROUND: Synthetic peptide immunoregulatory epitopes are a new class of immunotherapy to treat allergic rhinoconjunctivitis (ARC). Grass allergen peptides, comprising 7 synthetic T-cell epitopes derived from Cyn d 1, Lol p 5, Dac g 5, Hol l 5, and Phl p 5, is investigated for treatment of grass pollen-induced ARC. OBJECTIVE: We sought to evaluate the efficacy, safety, and tolerability of intradermally administered grass allergen peptides. METHODS: A multicenter, randomized, double-blind, placebo-controlled study evaluated 3 regimens of grass allergen peptides versus placebo in patients with grass pollen-induced allergy (18-65 years)...
August 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28173936/left-sided-early-onset-colorectal-carcinomas-a-sporadic-neoplasm-with-aggressive-behavior
#10
Emanuela Pilozzi, Laura Lorenzon, Simone Lo Baido, Mario Ferri, Enrico Duranti, Flavio Fochetti, Paolo Mercantini, Giovanni Ramacciato, Genoveffa Balducci, Luigi Ruco
BACKGROUND: Early onset (≤50y) colorectal carcinomas (EO-CRCs) are increasing in incidence according to epidemiological data. We investigated clinical-pathological, molecular features and outcomes of 62 left sided EO-CRCs (EOLS-CRCs) and compared them to a group of late onset (≥65) LS-CRCs (LOLS-CRCs). MATERIALS AND METHODS: Samples were evaluated for pathological features and microsatellite instability (MSI). Overall survival (OS), disease free survival (DFS) and disease specific survival were evaluated in both groups...
September 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/27983850/computational-modeling-of-the-catalytic-cycle-of-glutathione-peroxidase-nanomimic
#11
Ramesh Kheirabadi, Mohammad Izadyar
To elucidate the role of a derivative of ebselen as a mimic of the antioxidant selenoenzyme glutathione peroxidase, density functional theory and solvent-assisted proton exchange (SAPE) were applied to model the reaction mechanism in a catalytic cycle. This mimic plays the role of glutathione peroxidase through a four-step catalytic cycle. The first step is described as the oxidation of 1 in the presence of hydrogen peroxide, while selenoxide is reduced by methanthiol at the second step. In the third step of the reaction, the reduction of selenenylsulfide occurs by methanthiol, and the selenenic acid is dehydrated at the final step...
December 29, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27936048/linear-in-the-parameters-oblique-least-squares-lols-provides-more-accurate-estimates-of-density-dependent-survival
#12
Vasco M N C S Vieira, Aschwin H Engelen, Oscar R Huanel, Marie-Laure Guillemin
Survival is a fundamental demographic component and the importance of its accurate estimation goes beyond the traditional estimation of life expectancy. The evolutionary stability of isomorphic biphasic life-cycles and the occurrence of its different ploidy phases at uneven abundances are hypothesized to be driven by differences in survival rates between haploids and diploids. We monitored Gracilaria chilensis, a commercially exploited red alga with an isomorphic biphasic life-cycle, having found density-dependent survival with competition and Allee effects...
2016: PloS One
https://www.readbyqxmd.com/read/27871940/bacterial-lipoproteins-biogenesis-sorting-and-quality-control
#13
REVIEW
Shin-Ichiro Narita, Hajime Tokuda
Bacterial lipoproteins are a subset of membrane proteins localized on either leaflet of the lipid bilayer. These proteins are anchored to membranes through their N-terminal lipid moiety attached to a conserved Cys. Since the protein moiety of most lipoproteins is hydrophilic, they are expected to play various roles in a hydrophilic environment outside the cytoplasmic membrane. Gram-negative bacteria such as Escherichia coli possess an outer membrane, to which most lipoproteins are sorted. The Lol pathway plays a central role in the sorting of lipoproteins to the outer membrane after lipoprotein precursors are processed to mature forms in the cytoplasmic membrane...
November 19, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27826675/effects-of-clary-sage-oil-and-its-main-components-linalool-and-linalyl-acetate-on-the-plasma-membrane-of-candida-albicans-an-in-vivo-epr-study
#14
Ágnes Blaskó, Zoltán Gazdag, Pál Gróf, Gábor Máté, Szilvia Sárosi, Judit Krisch, Csaba Vágvölgyi, Lilla Makszin, Miklós Pesti
The effects of clary sage (Salvia sclarea L.) oil (CS-oil), and its two main components, linalool (Lol) and linalyl acetate (LA), on cells of the eukaryotic human pathogen yeast Candida albicans were studied. Dynamic and thermodynamic properties of the plasma membrane were investigated by electron paramagnetic resonance (EPR) spectroscopy, with 5-doxylstearic acid (5-SASL) and 16-SASL as spin labels. The monitoring of the head group regions with 5-SASL revealed break-point frequency decrease in a temperature dependent manner of the plasma membrane between 9...
November 8, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27723974/infrared-spectra-of-novel-ngbeso2-complexes-ng-ne-ar-kr-xe-in-low-temperature-matrices
#15
Wenjie Yu, Xing Liu, Bing Xu, Xiaopeng Xing, Xuefeng Wang
The novel noble-gas complexes NgBeSO2 (Ng=Ne, Ar, Kr, Xe) have been prepared in the laser-evaporated beryllium atom reactions with SO2 in low-temperature matrices. Doped with heavier noble gas, the guest (Ar, Kr, Xe) atom can substitute neon to form more stable complex. Infrared spectroscopy and theoretical calculations are used to confirm the band assignment. The dissociation energies are calculated at 0.9, 4.0, 4.7, and 6.0 kcal/mol for NeBeSO2, ArBeSO2, KrBeSO2, and XeBeSO2, respectively, at the CCSD(T) level...
October 11, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27645386/transcriptional-responses-of-escherichia-coli-to-a-small-molecule-inhibitor-of-lolcde-an-essential-component-of-the-lipoprotein-transport-pathway
#16
Christian Lorenz, Thomas J Dougherty, Stephen Lory
In Gram-negative bacteria, a dedicated machinery consisting of LolABCDE components targets lipoproteins to the outer membrane. We used a previously identified small-molecule inhibitor of the LolCDE complex of Escherichia coli to assess the global transcriptional consequences of interference with lipoprotein transport. Exposure of E. coli to the LolCDE inhibitor at concentrations leading to minimal and significant growth inhibition, followed by transcriptome sequencing, identified a small group of genes whose transcript levels were decreased and a larger group whose mRNA levels increased 10- to 100-fold compared to those of untreated cells...
December 1, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27536051/a-rare-manifestation-of-uveitis-glaucoma-hyphema-syndrome
#17
David Cordeiro Sousa, Inês Leal, Mun Yueh Faria, Luís Abegão Pinto
AIMS: To report a case of a patient who developed uveitis-glaucoma-hyphema (UGH) syndrome after an uneventful cataract surgery and to discuss risk factors, diagnostic challenges, management options, and clinical implications. BACKGROUND: Uveitis-glaucoma-hyphema syndrome is a rare but potentially serious cataract surgery complication. Clinical manifestations include increased intraocular pressure (IOP), anterior chamber inflammation, and recurrent hyphema or microhyphema...
May 2016: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/27454864/component-resolved-diagnostics-in-vernal-conjunctivitis
#18
Alicia Armentia, Eugenia Sanchís, Javier A Montero
PURPOSE OF REVIEW: Conventional diagnostic tests in allergy are insufficient to clarify the cause of vernal conjunctivitis. Component-resolved diagnostic (CRD) by microarray allergen assay may be useful in detecting allergens that might be involved in the inflammatory process. RECENT FINDINGS: In a recent trial in patients suffered from eosinophilic esophagitis, after 2 years of the CRD-guided exclusion diet and specific immunotherapy, significant clinical improvement was observed, and 68% of patients were discharged (cure based on negative biopsy, no symptoms, and no medication intake)...
October 2016: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27156376/impulsivity-in-multiplayer-online-battle-arena-gamers-preliminary-results-on-experimental-and-self-report-measures
#19
Filip Nuyens, Jory Deleuze, Pierre Maurage, Mark D Griffiths, Daria J Kuss, Joël Billieux
Background and aims Multiplayer Online Battle Arena (MOBA) games have become the most popular type of video games played worldwide, superseding the playing of Massively Multiplayer Online Role-Playing Games and First-Person Shooter games. However, empirical studies focusing on the use and abuse of MOBA games are still very limited, particularly regarding impulsivity, which is an indicator of addictive states but has not yet been explored in MOBA games. In this context, the objective of the present study is to explore the associations between impulsivity and symptoms of addictive use of MOBA games in a sample of highly involved League of Legends (LoL, currently the most popular MOBA game) gamers...
June 2016: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/27118314/the-anaerobic-linalool-metabolism-in-thauera-linaloolentis-47-lol
#20
Robert Marmulla, Edinson Puentes Cala, Stephanie Markert, Thomas Schweder, Jens Harder
BACKGROUND: The betaproteobacterium Thauera linaloolentis 47Lol(T) was isolated on the tertiary monoterpene alcohol (R,S)-linalool as sole carbon and energy source under denitrifying conditions. Growth experiments indicated the formation of geraniol and geranial. Thus, a 3,1-hydroxyl-Δ(1)-Δ(2)-mutase (linalool isomerase) activity may initiate the degradation, followed by enzymes of the acyclic terpene utilization (Atu) and leucine/isovalerate utilization (Liu) pathways that were extensively studied in Pseudomonas spp...
April 27, 2016: BMC Microbiology
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