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Marcin Grabowicz
The Gram-negative outer membrane (OM) is a potent permeability barrier against antibiotics, limiting clinical options amid mounting rates of resistance. The Lol transport pathway delivers lipoproteins to the OM. All the OM assembly machines require one or more OM lipoprotein to function, making the Lol pathway central for all aspects of OM biogenesis. The Lol pathways of many medically important species clearly deviate from the Escherichia coli paradigm, perhaps with implications for efforts to develop novel antibiotics...
March 7, 2018: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
Yue Li, Lei Zhang, Kehong Long, Hui Gong, Hao Lei
A growing body of literature has suggested that video game playing can induce functional and structural plasticity of the brain. The underlying mechanisms, however, remain poorly understood. In this study, functional near-infrared spectroscopy (fNIRS) was used to record prefrontal activities in 24 experienced game players when they played a massively multiplayer online battle arena (MOBA) video game, League of Legends (LOL), under naturalistic conditions. It was observed that game onset was associated with significant activations in the ventrolateral prefrontal cortex (VLPFC) and concomitant deactivations in the dorsolateral prefrontal cortex (DLPFC) and frontal pole area (FPA)...
February 16, 2018: Journal of Biophotonics
Nicholas N Nickerson, Christine C Jao, Yiming Xu, John Quinn, Elizabeth Skippington, Mary Kate Alexander, Anh Miu, Nicholas Skelton, Jessica V Hankins, Michael S Lopez, Christopher M Koth, Steven Rutherford, Mireille Nishiyama
The outer membrane is an essential structural component of Gram-negative bacteria that is composed of lipoproteins, lipopolysaccharides, phospholipids, and integral β-barrel membrane proteins. A dedicated machinery, called the Lol system, ensures proper trafficking of lipoproteins from the inner to the outer membrane. The LolCDE ABC transporter is the inner membrane component, which is essential for bacterial viability. Here, we report a novel pyrrolopyrimidinedione compound, G0507, which was identified in a phenotypic screen for inhibitors of E...
January 16, 2018: Antimicrobial Agents and Chemotherapy
L Conti, E Baldini, P Capelli, C Capelli
INTRODUCTION: The obturator hernia is a rare pelvic hernia that often comes in the shape of bowel obstruction caused by the presence of an intestinal segment, more often ileum, passing trough the obturator foramen of the pelvic wall (Fig. 1). This type of hernia accounts for 0.5-1.4% of all hernias. CASE PRESENTATION: We report the clinical case of a 84-year-old woman with no previous surgical interventions, who went to the emergency room complaining of vomit and nausea, bowels closed to gas and stool, which she had experienced for three previous days...
December 7, 2017: International Journal of Surgery Case Reports
Trieu Phat Luu, Justin A Brantley, Sho Nakagome, Fangshi Zhu, Jose L Contreras-Vidal
This study investigated electrocortical dynamics of human walking across different unconstrained walking conditions (i.e., level ground (LW), ramp ascent (RA), and stair ascent (SA)). Non-invasive active-electrode scalp electroencephalography (EEG) signals were recorded and a systematic EEG processing method was implemented to reduce artifacts. Source localization combined with independent component analysis and k-means clustering revealed the involvement of four clusters in the brain during the walking tasks: Left and Right Occipital Lobe (LOL, ROL), Posterior Parietal Cortex (PPC), and Central Sensorimotor Cortex (SMC)...
2017: PloS One
Huanan Du, Xu Zhang, Ruchun Zhang, Lu Zhang, Dianyu Yu, Lianzhou Jiang
Rosa acicularis seed oil was extracted from Rosa acicularis seeds by the ultrasonic-assisted aqueous enzymatic method using cellulase and protease. Based on a single experiment, Plackett-Burman design was applied to ultrasonic-assisted aqueous enzymatic extraction of wild rose seed oil. The effects of enzyme amount, hydrolysis temperature and initial pH on total extraction rate of wild rose seed oil was studied by using Box-Behnken optimize methodology. Chemical characteristics of a sample of Rosa acicularis seeds and Rosa acicularis seed oil were characterized in this work...
December 1, 2017: Journal of Oleo Science
Ali Kordzadeh, Alexandros Charalabopoulos
No abstract text is available yet for this article.
September 14, 2017: Surgery
Nimerta Kumari, Friedrich Götz, Minh-Thu Nguyen
In gram-negative bacteria, the ABC transporter LolCDE complex translocates outer membrane-specific lipoproteins (Lpp) from the inner membrane to the outer membrane. Lpp possessing aspartate (Asp) at position +2 are not translocated because it functions as a LolCDE avoidance signal. In gram-positive bacteria, lacking an outer membrane and the Lol system, Lpp are only anchored at the outer leaflet of the cytoplasmic membrane. However, the release of Lpp particularly in pathogenic or commensal species is crucial for immune modulation...
December 2017: MicrobiologyOpen
Omar Rodriguez-Acevedo, Kristen E Elstner, Anita S W Jacombs, John W Read, Rodrigo Tomazini Martins, Fernando Arduini, Michael Wehrhahm, Colette Craft, Peter H Cosman, Anthony N Dardano, Nabeel Ibrahim
INTRODUCTION: Operative management of complex ventral hernia still remains a significant challenge for surgeons. Closure of large defects in the unprepared abdomen has serious pathophysiological consequences due to chronic contraction and retraction of the lateral abdominal wall muscles. We report outcomes of 56 consecutive patients who had preoperative Botulinum toxin A (BTA) abdominal wall relaxation facilitating closure and repair. METHODS: This was a prospective observational study of 56 patients who underwent ultrasound-guided BTA into the lateral abdominal oblique muscles prior to elective ventral hernia repair between November 2012 and January 2017...
February 2018: Surgical Endoscopy
Tatsiana Shymanovich, Nikki D Charlton, Ashleigh M Musso, Jonathan Scheerer, Nadja B Cech, Stanley H Faeth, Carolyn A Young
The endophyte presence and diversity in natural populations of Poa alsodes were evaluated along a latitudinal transect from the southern distribution range in North Carolina to New York. Two distinct Epichloë hybrid taxa were identified from 23 populations. Each taxon could easily be distinguished by polymerase chain reaction (PCR) genotyping with primers designed to mating type genes and alkaloid biosynthesis genes that encode key pathway steps for ergot alkaloids, indole-diterpenes, lolines, and peramine...
May 2017: Mycologia
Gábor Máté, Dominika Kovács, Zoltán Gazdag, Miklós Pesti, Árpád Szántó
The present study investigated the linalool (Lol)-induced effects in acute toxicity tests in the human pathogen Candida albicans (C. albicans). Lol treatments induced reduced germ tube formation of the pathogen, which plays a crucial role in the virulence. In comparison with the untreated control, the exposure of 107 cells ml(-1) to 0.7 mM or 1.4 mM Lol for one hour induced 20% and 30% decrements, respectively, in the colony-forming ability. At the same time, these treatments caused dose-dependent decrease in the levels of superoxide anion radical and total reactive oxygen species, while there was 1...
June 2017: Acta Biologica Hungarica
Nyiang Kennet Nkungli, Julius Numbonui Ghogomu
Thiosemicarbazones display diverse pharmacological properties, including antimalarial activities. Their pharmacological activities have been studied in depth, but little of this research has focused on their antimalarial mode of action. To elucidate this antimalarial mechanism, we investigated the nature of the interactions between iron(III) protoporphyrin IX (Fe(III)PPIX) and the thione-thiol tautomers of 4-methoxyacetophenone thiosemicarbazone (MAPTSC). Dispersion-corrected density functional theory (DFT-D3), the quantum theory of atoms in molecules (QTAIM), the noncovalent interaction (NCI) index, the electron localization function (ELF), the localized orbital locator (LOL), and thermodynamic calculations were employed in this work...
July 2017: Journal of Molecular Modeling
Dominik Naglav, Briac Tobey, Benjamin Lyhs, Beate Römer, Dieter Bläser, Christoph Wölper, Georg Jansen, Stephan Schulz
[Ph4 P]2 [Be(N3 )4 ] (1) and [PNP]2 [Be(N3 )4 ] (2; PNP=Ph3 PNPPh3 ) were synthesized by reacting Be(N3 )2 with [Ph4 P]N3 and [PNP]N3 . Compound 1 represents the first structurally characterized homoleptic beryllium azide. The electronic structure and bonding situation in the tetraazidoberyllate dianion [Be(N3 )4 ](2-) were investigated by quantum-chemical calculations (NPA, ELF, LOL).
May 29, 2017: Angewandte Chemie
Anderson Weber, Fabio Rodrigo Thewes, Rogerio de Oliveira Anese, Vanderlei Both, Elizandra Pivotto Pavanello, Auri Brackmann
The objective of the present work was to evaluate the appropriate respiratory quotient (RQ) value to achieve a safe lowest oxygen limit (LOL), during storage of 'Fuji Suprema' apples, in dynamic controlled atmosphere (DCA), treated with or without 1-methylcyclopropene (1-MCP). The apples were stored in DCA-RQ, a new technology for storing fruits, and were compared with the HarvestWatch™, a system based on chlorophyll fluorescence DCA (DCA-CF), and static controlled atmosphere. DCA-RQ1.5 is the most suited for the storage of 'Fuji Suprema' apples...
November 15, 2017: Food Chemistry
S Starchenka, A J Bell, J Mwange, M A Skinner, M D Heath
BACKGROUND: Subcutaneous allergen immunotherapy (SCIT) is a well-documented treatment for allergic disease which involves injections of native allergen or modified (allergoid) extracts. The use of allergoid vaccines is a growing sector of the allergy immunotherapy market, associated with shorter-course therapy. The aim of this study was the structural and immunological characterisation of group 1 (Lol p 1) IgG-binding epitopes within a complex mix grass allergoid formulation containing rye grass...
2017: World Allergy Organization Journal
Vasco M N C S Vieira, Aschwin H Engelen, Oscar R Huanel, Marie-Laure Guillemin
[This corrects the article DOI: 10.1371/journal.pone.0167418.].
2017: PloS One
Anne K Ellis, Charles W Frankish, Robyn E O'Hehir, Kristen Armstrong, Lisa Steacy, Mark Larché, Roderick P Hafner
BACKGROUND: Synthetic peptide immunoregulatory epitopes are a new class of immunotherapy to treat allergic rhinoconjunctivitis (ARC). Grass allergen peptides, comprising 7 synthetic T-cell epitopes derived from Cyn d 1, Lol p 5, Dac g 5, Hol l 5, and Phl p 5, is investigated for treatment of grass pollen-induced ARC. OBJECTIVE: We sought to evaluate the efficacy, safety, and tolerability of intradermally administered grass allergen peptides. METHODS: A multicenter, randomized, double-blind, placebo-controlled study evaluated 3 regimens of grass allergen peptides versus placebo in patients with grass pollen-induced allergy (18-65 years)...
August 2017: Journal of Allergy and Clinical Immunology
Emanuela Pilozzi, Laura Lorenzon, Simone Lo Baido, Mario Ferri, Enrico Duranti, Flavio Fochetti, Paolo Mercantini, Giovanni Ramacciato, Genoveffa Balducci, Luigi Ruco
BACKGROUND: Early onset (≤50y) colorectal carcinomas (EO-CRCs) are increasing in incidence according to epidemiological data. We investigated clinical-pathological, molecular features and outcomes of 62 left sided EO-CRCs (EOLS-CRCs) and compared them to a group of late onset (≥65) LS-CRCs (LOLS-CRCs). MATERIALS AND METHODS: Samples were evaluated for pathological features and microsatellite instability (MSI). Overall survival (OS), disease free survival (DFS) and disease specific survival were evaluated in both groups...
September 2017: American Journal of Surgery
Ramesh Kheirabadi, Mohammad Izadyar
To elucidate the role of a derivative of ebselen as a mimic of the antioxidant selenoenzyme glutathione peroxidase, density functional theory and solvent-assisted proton exchange (SAPE) were applied to model the reaction mechanism in a catalytic cycle. This mimic plays the role of glutathione peroxidase through a four-step catalytic cycle. The first step is described as the oxidation of 1 in the presence of hydrogen peroxide, while selenoxide is reduced by methanthiol at the second step. In the third step of the reaction, the reduction of selenenylsulfide occurs by methanthiol, and the selenenic acid is dehydrated at the final step...
December 29, 2016: Journal of Physical Chemistry. A
Vasco M N C S Vieira, Aschwin H Engelen, Oscar R Huanel, Marie-Laure Guillemin
Survival is a fundamental demographic component and the importance of its accurate estimation goes beyond the traditional estimation of life expectancy. The evolutionary stability of isomorphic biphasic life-cycles and the occurrence of its different ploidy phases at uneven abundances are hypothesized to be driven by differences in survival rates between haploids and diploids. We monitored Gracilaria chilensis, a commercially exploited red alga with an isomorphic biphasic life-cycle, having found density-dependent survival with competition and Allee effects...
2016: PloS One
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