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Lymphomatous meningitis

Guido Ahle, Valérie Touitou, Nathalie Cassoux, Marie Bouyon, Catherine Humbrecht, Hélène Oesterlé, Alexander Baraniskin, Carole Soussain, Ludovic Nguyen-Them, Claude Gaultier, Khê Hoang-Xuan, Caroline Houillier
Importance: Visual impairment in primary central nervous system lymphoma (PCNSL) is caused mostly by intraocular lymphomatous involvement (vitritis and retinal infiltration), whereas optic nerve infiltration (ONI) is a rare condition. Objective: To describe the clinical presentation of ONI, its imaging characteristics, and outcome. Design, Setting and Participants: A total of 752 patients diagnosed with PCNSL were retrospectively identified from the databases of 3 French hospitals from January 1, 1998, through December 31, 2014...
November 1, 2017: JAMA Neurology
Christian Cordano, Bardia Nourbakhsh, Ethan Brown, Christine Glastonbury
No abstract text is available yet for this article.
September 2017: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Tomoyuki Saga, Toshimichi Ishihara, Michiyo Kanagawa
Froin's syndrome is characterized by a combination of marked coagulation, elevated protein levels, and xanthochromia of the cerebrospinal fluid (CSF). It is due to blockage of CSF flow by a spinal cord mass or results from meningeal irritation during meningitis. However, Froin's syndrome has not been reported in hematological malignancies. Herein, we present two cases of lymphomatous leptomeningitis with Froin's syndrome. A 66-year-old man suffered consciousness disturbance during chemotherapy for a relapse of peripheral T-cell lymphoma, not otherwise specified...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Hemant Murthy, Claudio Anasetti, Ernesto Ayala
BACKGROUND: Leukemic and lymphomatous meningitis is a major presentation of primary or secondary central nervous system (CNS) involvement by aggressive lymphomas or acute leukemia. METHODS: The medical literature and ongoing clinical trials were reviewed on the clinical presentation, diagnosis, prognosis, prevention, and treatment of leukemic and lymphomatous meningitis. RESULTS: Treatment for secondary leukemic and lymphomatous meningitis remains unsatisfactory, and efforts should be made to prevent and treat subclinical disease...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
Maria Teresa Mandara, Luca Motta, Pietro Calò
In cats, lymphoma (lymphosarcoma) is the most common neoplasm affecting the spinal cord and the second most common intracranial tumour. Although lymphoma commonly develops in the spinal cord as a part of a multicentric process, a primary form may occur. Lymphoma can exhibit a wide range of morphological patterns, including intraparenchymal brain mass, lymphomatosis cerebri, intravascular lymphoma, lymphomatous choroiditis and meningitis, extradural, intradural-extramedullary or intramedullary lymphoma in the spinal cord, or neurolymphomatosis in the peripheral nerves...
October 2016: Veterinary Journal
Ravindra Kumar Garg, Hardeep Singh Malhotra, Amita Jain
Tuberculous meningitis is a serious infection caused by Mycobacterium tuberculosis. Early diagnosis is the key to success of treatment. Neuroimaging plays a crucial role in the early and accurate diagnosis of tuberculous meningitis and its disabling complications. Magnetic resonance imaging is considered superior to computed tomography. Neuroimaging characteristics include leptomeningeal and basal cisternal enhancement, hydrocephalus, periventricular infarcts, and tuberculoma. Partially treated pyogenic meningitis, cryptococcal meningitis, viral encephalitis, carcinomatous, and lymphomatous meningitis may have many similar neuroimaging characteristics, and differentiation from tuberculous meningitis at times on the basis of neuroimaging characteristics becomes difficult...
March 2016: Neurology India
Marc Chamberlain, Riccardo Soffietti, Jeffrey Raizer, Roberta Rudà, Dieta Brandsma, Willem Boogerd, Sophie Taillibert, Morris D Groves, Emilie Le Rhun, Larry Junck, Martin van den Bent, Patrick Y Wen, Kurt A Jaeckle
PURPOSE: To date, response criteria and optimal methods for assessment of outcome have not been standardized in patients with leptomeningeal metastasis (LM). METHODS: A Response Assessment in Neuro-Oncology working group of experts in LM critically reviewed published literature regarding randomized clinical trials (RCTs) and trial design in patients with LM. RESULTS: A literature review determined that 6 RCTs regarding the treatment of LM have been published, all of which assessed the response to intra-CSF based chemotherapy...
September 2014: Neuro-oncology
Line Cuinat, Nathalie Nasr, Jeanine Manuela Kamsu, Frédéric Tanchoux, Fabrice Bonneville, Vincent Larrue
BACKGROUND: Cortical subarachnoid hemorrhage and meningitis sometimes present as episodes of transient neurologic dysfunction mimicking transient ischemic attack (TIA). In the present study, we sought to determine the frequency of meningeal disease among patients treated in a TIA clinic. METHODS: Data from patients consecutively admitted to a TIA clinic were retrospectively analyzed. Patients were classified as ischemic events (TIA or minor stroke) or nonischemic events using clinical data and findings from brain imaging and ultrasound studies...
July 2014: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Julia Illán, Marta Simo, Cristina Serrano, Susana Castañón, Raquel Gonzalo, María Martínez-García, Javier Pardo, Lidia Gómez, Miguel Navarro, Javier Pérez Altozano, Ruth Alvarez, Jordi Bruna, Dolores Subirá
Dissemination of neoplastic cells into the cerebrospinal fluid (CSF) and leptomeninges is a devastating complication in patients with epithelial cell neoplasia (leptomeningeal carcinomatosis [LC]) and lymphomas (lymphomatous meningitis [LyM]). Information about the surrounding inflammatory cell populations is scarce. In this study, flow cytometry immunophenotyping was used to describe the distribution of the main leukocyte populations in the CSF of 83 patients diagnosed with neoplastic meningitis (LC, n = 65; LyM, n = 18)...
December 2014: Translational Research: the Journal of Laboratory and Clinical Medicine
Kyohei Kin, Yasuhiro Ono, Yoshio Hisamatsu, Satoshi Kuramoto, Atsushi Katsumata, Hideyuki Yoshida, Masamitsu Kawauchi, Satoko Nakamura
Primary leptomeningeal lymphoma(PLML)is a neoplastic meningitis of lymphomatous origin without parenchymal central nervous system(CNS)disease or a systemic tumor. We report a case of PLML that presented with epileptic seizure, and review relevant literature. A 27-year-old man was brought to the emergency department with an epileptic seizure. Two months later, he was again brought to the emergency department with an epileptic seizure. MRI showed enhanced lesions on the surface of the right cerebellar hemisphere, right parietal sulci, and interhemispheric surface of the frontal lobes...
March 2014: No Shinkei Geka. Neurological Surgery
Adolfo Ramirez-Zamora, Sarkis Morales-Vidal, Jasvinder Chawla, José Biller
Neurolymphomatosis (NL) refers to a lymphomatous infiltration of peripheral nerves associated with central nervous system or systemic lymphoma, or alternatively, neurodiagnostic evidence of nerve enhancement and/or enlargement beyond the dural sleeve in the setting of primary central nervous system lymphoma or systemic lymphoma. NL is a rare complication of systemic cancer with heterogeneous clinical presentations and an elusive diagnosis. Diagnosis usually requires the demonstration of infiltrating malignant lymphocytes in the peripheral nerve...
2013: Frontiers in Neurology
Tobias Birnbaum, Louisa von Baumgarten, Christine Dudel, Andreas Straube
Most primary central nervous system lymphomas (PCNSL) are highly malignant B-cell non-Hodgkin lymphomas. First-line therapy consists of high-dose methotrexate-based chemotherapy with or without whole brain radiotherapy. However, no standard of care is defined for refractory or recurrent PCNSL. We report a patient with lymphomatous meningitis, which was refractory to standard treatment but was successfully controlled for more than 6 years with intraventricular rituximab. Apart from two infections of the Ommaya reservoir, no severe side effects of intraventricular long-term treatment could be detected...
February 2014: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Eui Sik Kim, Pyung Gohn Goh, Yun Jeung Kim, Su Youn Lee, Hee Seok Moon, Jae Kyu Sung, Byung Seok Lee, Hyun Yong Jeong
Mantle cell lymphoma (MCL) is an uncommon type of gastrointestinal lymphoma. MCL is a distinct subtype of B-cell non-Hodgkin lymphomas. The major subtype of MCL is characterized by the presence of multiple lymphomatous polyposis (MLP), in which multiple polyps are observed along the gastrointestinal tract. The malignant cells express pan B-cell marker and the T-cell marker cluster of differentiation 5. The chromosomal translocation t(11;14)(q13;q32) that causes cyclin D1 overexpression is commonly observed on the cytogenetic analysis of MCL...
July 2012: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
Marc C Chamberlain
Neoplastic meningitis, commonly referred to as carcinomatosis meningitis, leukemic meningitis, or lymphomatous meningitis, is the third most common central nervous system metastatic complication of systemic cancer and is the most morbid of central nervous system metastases. The disease is challenging to treat for a variety of reasons, including challenges in making a diagnosis of neoplastic meningitis and lack of standardized treatment due to the paucity of clinical trials addressing treatment of neoplastic meningitis...
August 2012: Hematology/oncology Clinics of North America
Alessandra Stacchini, Sabrina Aliberti, Anna Demurtas, Giulia Benevolo, Laura Godio
BACKGROUND: Flow cytometry (FC) is considered a sensitive and specific technique for the detection of occult lymphoma cells in cerebrospinal fluid (CSF). METHODS: The diagnostic sensitivity of a FC approach which uses a combination of 10 antibodies, a single-tube evaluation, and a six-color instrument, was evaluated and compared to conventional cytology (CC) for the detection of lymphomatous cells in the CSF of 44 patients affected by B-cell non-Hodgkin's lymphoma (B-NHL) considered at high risk of central nervous system spread...
May 2012: Cytometry. Part B, Clinical Cytometry
Manmeet S Ahluwalia, Paul K Wallace, David M Peereboom
In patients with neoplastic meningitis (NM), early diagnosis is highly desirable because the rapid institution of intrathecal therapy may mitigate the course of the disease. Cytology, long considered the "gold standard" for diagnosis, has low sensitivity because of both the paucity of cells in the cerebrospinal fluid (CSF) and morphological similarities between benign and malignant cells. A comprehensive review of the literature from 2005 through 2011 was performed that focused on diagnostic modalities for lymphomatous meningitis...
April 1, 2012: Cancer
E Finke, R Hage, A Donnio, C Bomahou, J Guyomarch, C Sutter, E Ventura, H Merle
INTRODUCTION: Non-Hodgkin lymphomas (NHLs) constitute a group of heterogeneous diseases that can arise in lymphatic nodal or extranodal sites. Ocular lymphomas account for 1% of all NHLs. Tumor of the orbit, which can lead to compression of the optic nerve, is the most frequent presentation of the disease. Primary infiltration of the optic nerve and its sheath remains exceptional. OBSERVATION: We report the case of a 51-year-old female patient treated for a NHL...
February 2012: Journal Français D'ophtalmologie
Marc C Chamberlain
No abstract text is available yet for this article.
May 2011: Clinical Advances in Hematology & Oncology: H&O
Padmaja Sudhakar, Francisco Rivas Rodriguez, Jonathan D Trobe
Restricted diffusion in the optic nerve detected with MRI has been previously reported in infarction and inflammation but not in infiltrative neoplasm. We report a 44-year-old man with recently diagnosed non-Hodgkin B-cell lymphoma who developed an acute left optic neuropathy. MRI showed no evidence of brain parenchymal or meningeal lymphoma but did show restricted diffusion in the intraorbital portion of the affected optic nerve. Despite treatment with corticosteroid, standard chemotherapy, and orbital X-irradiation, visual function did not improve...
December 2011: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
M Chamberlain, P Kormanik
A prospective study of combined modality therapy of non-AIDS related lymphomatous meningitis was carried out. Lymphomatous meningitis is diagnosed increasingly as anti-lymphoma therapies become more effective and result in prolonged patient survival. Twenty-two patients (range 38-69 years; median 60) with lymphomatous meningitis due to metastatic non-AIDS related non-Hodgkins lymphoma were treated. Neurologic presentation included: headache (n=13); cranial neuropathies (n=9); ataxia (n=5); cauda equina syndrome (n=3); myelopathy (n=1); and meningismus (n=1)...
November 1997: Oncology Reports
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