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Diabetes in pregnancy

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https://www.readbyqxmd.com/read/29155213/human-umbilical-vein-endothelium-derived-exosomes-play-a-role-in-foetoplacental-endothelial-dysfunction-in-gestational-diabetes-mellitus
#1
Tamara Sáez, Rocío Salsoso, Andrea Leiva, Fernando Toledo, Paul de Vos, Marijke Faas, Luis Sobrevia
Gestational diabetes mellitus (GDM) characterizes by foetoplacental endothelial dysfunction. Human umbilical vein endothelial cells (HUVECs) from women with GDM show increased L-arginine transport via the human cationic amino acid transporter 1 (hCAT-1). Moreover, expression of endothelial nitric oxide synthase (eNOS) and nitric oxide synthesis are increased. Exosomes are increased in maternal plasma from GDM. We evaluated the role of foetoplacental endothelial exosomes on endothelial dysfunction in GDM. Exosomes were isolated from HUVECs from normal (ExN) and GDM (ExGDM) pregnancies...
November 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29154942/levels-of-palmitic-acid-ester-of-hydroxystearic-acid-pahsa-are-reduced-in-the-breast-milk-of-obese-mothers
#2
Marie Brezinova, Ondrej Kuda, Jana Hansikova, Martina Rombaldova, Laurence Balas, Kristina Bardova, Thierry Durand, Martin Rossmeisl, Marcela Cerna, Zbynek Stranak, Jan Kopecky
To achieve optimal development of a newborn, breastfeeding is extensively recommended, but little is known about the role of non-nutritive bioactive milk components. We aimed to characterize the fatty acid esters of hydroxy fatty acids (FAHFAs), namely palmitic acid hydroxystearic acids (PAHSAs)-endogenous lipids with anti-inflammatory and anti-diabetic properties, in human breast milk. Breast milk samples from 30 lean (BMI=19-23) and 23 obese (BMI>30) women were collected 72h postpartum. Adipose tissue and milk samples were harvested from C57BL/6J mice...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29153679/hypertensive-disorders-of-pregnancy-in-women-with-gestational-diabetes-mellitus-from-rio-de-janeiro-brazil
#3
Luciana Lourenço Gomes Dos Santos da Silva, Cláudia Saunders, Aline Bull Ferreira Campos, Gabriella Pinto Belfort, Patricia de Carvalho Padilha, Rosangela Alves Pereira, Rita Guérios Bornia
Pregnant women with Gestational Diabetes Mellitus (GDM) have a greater chance of developing Hypertensive Disorders of Pregnancy (HDP) by the effect of insulin resistance in nitric oxide action.This study aims to describe factors associated with the development of HDP in pregnant women with GDM, assisted in a public maternity hospital in Rio de Janeiro, Brazil. This is a cross-sectional study including 292 pregnant adult women with GDM assisted at Maternidade Escola of the Universidade Federal do Rio de Janeiro...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29153659/a-simple-clinical-method-to-identify-women-at-higher-risk-of-preeclampsia
#4
Effie Viguiliouk, Alison L Park, Howard Berger, Michael P Geary, Joel G Ray
An outstanding issue is how to efficiently identify women at high risk of preeclampsia. This retrospective cohort study included 8672 pregnancies at a single centre in Toronto. We tested our simple method - presence vs. absence of≥1 major (pre-pregnancy BMI>30kg/m(2), chronic hypertension, pre-pregnancy diabetes mellitus and assisted reproductive therapy) or≥2 minor (prior stillbirth, age>40years, nulliparity, multifetal pregnancy, chronic kidney disease, and SLE) risk factors for PE. The RR of PE was 8...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29150756/impact-of-risk-factors-for-gestational-diabetes-gdm-on-pregnancy-outcomes-in-women-with-gdm
#5
T Filardi, F Tavaglione, M Di Stasio, V Fazio, A Lenzi, S Morano
PURPOSE: In this study, we evaluated the impact of risk factors for gestational diabetes on clinical/biochemical parameters and maternal/fetal outcomes. METHODS: One hundred eighty-three (n 183) women (age 33.8 ± 5.5 years, 59% Caucasians, 41% non-Caucasians) with gestational diabetes were included in the study. Anamnestic information, anthropometric and laboratory parameters, and maternal and fetal outcomes at delivery were collected. RESULTS: Insulin therapy prevalence was higher in Asians vs Caucasians (p = 0...
November 17, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29150167/reproductive-factors-in-relation-to-heart-failure-in-women-a-systematic-review
#6
REVIEW
Renee Bolijn, N Charlotte Onland-Moret, Folkert W Asselbergs, Yvonne T van der Schouw
BACKGROUND: The biological mechanisms underlying the sex-related differences in risk of heart failure are still not well understood. The aim of this review was to provide an overview of the current evidence on the association between reproductive factors and risk of heart failure in women. METHODS: A systematic review of the literature was conducted. PubMed and Embase databases were searched for publications on the following reproductive factors as potential risk factors for heart failure in women: age at menarche, duration and frequency of the menstrual cycle, reproductive lifespan, use of contraception, polycystic ovarian syndrome (PCOS), pregnancy characteristics (e...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29149816/maternal-dyslipidaemia-in-pregnancy-with-gestational-diabetes-mellitus-possible-impact-in-the-foetoplacental-vascular-function-and-the-lipoprotein-in-the-neonatal-circulation
#7
Susana Contreras-Duarte, Lorena Carvajal, Barbara Fuenzalida, Claudette Cantin, Luis Sobrevia, Andrea Leiva
Dyslipidaemia occurs in pregnancy to secure foetal development. The mother shows a physiological increase in plasma total cholesterol and triglycerides (TG) as pregnancy progresses (i.e. maternal physiological dyslipidaemia in pregnancy). However, in some women pregnancy-associated dyslipidaemia exceeds this physiological adaptation. The consequences of this condition on the developing foetus include endothelial dysfunction of the foetoplacental vasculature and development of foetal aortic atherosclerosis. Gestational diabetes mellitus (GDM) associates with abnormal function of the foetoplacental vasculature due to foetal hyperglycaemia and hyperinsulinaemia, and associates with development of cardiovascular disease in adulthood...
November 16, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29149254/invited-commentary-gestational-hypertension-and-diabetes-a-major-public-health-concern
#8
Lewis H Kuller, Janet Catov
The obesity epidemic in the United States and other countries has contributed to an increase in the rates of gestational diabetes and hypertension. In the past, it was thought that most cases of gestational diabetes and hypertension would resolve after completion of pregnancy. In this issue of the Journal, Pace et al. (Am J Epidemiol. 2017;186(10):1115-1124) clearly documented that both gestational diabetes and hypertension lead to diabetes and hypertension and that the combination of both during pregnancy leads to very high rates of subsequent diabetes and hypertension...
November 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29146992/pre-pregnancy-overweight-or-obesity-and-gestational-diabetes-as-predictors-of-body-composition-in-offspring-twenty-years-later-evidence-from-two-birth-cohort-studies
#9
N Kaseva, M Vääräsmäki, H-M Matinolli, M Sipola-Leppänen, M Tikanmäki, K Heinonen, A Lano, D Wolke, S Andersson, M-R Järvelin, K Räikkönen, G Eriksson Johan, E Kajantie
BACKGROUND: Global prevalence of overweight/obesity and gestational diabetes (GDM) is increasing. In pregnant women both conditions affect offspring's later health. Overweight/obesity is a risk factor of GDM; to what extent maternal overweight/obesity explains long-term effects of GDM in offspring is unknown. OBJECTIVE: To evaluate effects of maternal pre-pregnancy overweight/obesity (BMI ⩾25 kg/m(2)) and GDM, occurring together or separately, on body composition among adult offspring...
November 17, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29144833/low-dietary-fiber-intake-increases-collinsella-abundance-in-the-gut-microbiota-of-overweight-and-obese-pregnant-women
#10
Luisa F Gomez-Arango, Helen L Barrett, Shelley A Wilkinson, Leonie K Callaway, H David McIntyre, Mark Morrison, Marloes Dekker Nitert
The gut microbiota contributes to the regulation of glucose metabolism in pregnancy. Abundance of the genus Collinsella is positively correlated with circulating insulin; however, it is unclear what determines Collinsella abundance. This study aims to validate the correlation between Collinsella and insulin and to elucidate if macronutrient intake alters Collinsella abundance and gut microbiota composition. Gut microbiota profiles were assessed by 16S rRNA sequencing in 57 overweight and 73 obese pregnant women from the SPRING (Study of PRobiotics IN Gestational diabetes) trial at 16 weeks gestation and correlated with metabolic hormone levels and macronutrient intake...
November 16, 2017: Gut Microbes
https://www.readbyqxmd.com/read/29143647/modelling-stillbirth-mortality-reduction-with-the-lives-saved-tool
#11
Hannah Blencowe, Victoria B Chou, Joy E Lawn, Zulfiqar A Bhutta
BACKGROUND: The worldwide burden of stillbirths is large, with an estimated 2.6 million babies stillborn in 2015 including 1.3 million dying during labour. The Every Newborn Action Plan set a stillbirth target of ≤12 per 1000 in all countries by 2030. Planning tools will be essential as countries set policy and plan investment to scale up interventions to meet this target. This paper summarises the approach taken for modelling the impact of scaling-up health interventions on stillbirths in the Lives Saved tool (LiST), and potential future refinements...
November 7, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29143549/negative-impact-of-hyperglycaemia-on-mouse-alveolar-development
#12
Mei-Yao He, Guang Wang, Sha-Sha Han, Ke Li, Ya Jin, Meng Liu, Zhen-Peng Si, Ju Wang, Guo-Sheng Liu, Xuesong Yang
Diabetes mellitus in pregnancy has been known to affect the embryonic development of various systems, including cardiovascular and nervous systems. However, whether this disease could have a negative impact on embryonic respiratory system remains controversial. In this study, we demonstrated that pregestational diabetes mellitus (PGDM)-induced defects in lung development in mice are mainly characterized by the changes in the morphological structure of the lung. Immunostaining and Western blotting showed that proliferation increased and apoptosis decreased in PGDM...
November 16, 2017: Cell Cycle
https://www.readbyqxmd.com/read/29142651/prevention-of-insulin-resistance-by-dietary-intervention-among-pregnant-mothers-a-randomized-controlled-trial
#13
Masoomeh Goodarzi-Khoigani, Seyed Saeed Mazloomy Mahmoodabad, Mohammad Hossein Baghiani Moghadam, Azadeh Nadjarzadeh, Farahnaz Mardanian, Hossein Fallahzadeh, Azam Dadkhah-Tirani
Background: Chronic insulin resistance (IR) is a basic part of the pathophysiology of gestational diabetes mellitus. Nutrition significantly impacts IR and weight loss reduces insulin levels, whereas weight gain increases the concentrations. Therefore, we surveyed the effect of nutrition intervention on IR in pregnant women and whether this effect is irrespective of weight gaining in accordance with Institute of Medicine limits. Methods: This prospective, randomized clinical trial was carried out among 150 primiparous pregnant mothers in fifteen health centers, five hospitals, and 15 private obstetrical offices in Isfahan...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29142561/feto-maternal-outcomes-and-glycemic-control-in-metformin-versus-insulin-treated-gestational-diabetics
#14
Rabia Arshad, Samia Khanam, Fuad Shaikh, Nasim Karim
Objective: To evaluate and compare feto-maternal outcomes and glycemic control in metformin versus insulin treated gestational diabetics. Methods: The study was conducted in 2010- 2012 as a part of M. Phil at Civil hospital, Lyari General Hospital and Mamji Hospital in Karachi. After written informed consent, 71 GDM diagnosed females with WHO criteria were enrolled. They were divided into two groups. Group-A, 32 females were given oral metformin 500 mg TDS while Group-B, 39 females were given insulin 0...
September 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29139556/delivery-outcomes-of-large-for-gestational-age-newborns-stratified-by-the-presence-or-absence-of-gestational-diabetes-mellitus
#15
Hadar Rosen, Anat Shmueli, Eran Ashwal, Liran Hiersch, Yariv Yogev, Amir Aviram
OBJECTIVE: To evaluate separate and combined contributions of gestational diabetes mellitus (GDM) and large-for-gestational age (LGA) on delivery outcomes. METHODS: In a retrospective cohort study of term singleton deliveries between 2007 and 2014 in Tel Aviv, Israel, outcomes were compared between non-GDM/AGA pregnancies (reference) and three study groups: non-GDM/LGA, GDM/appropriate for gestational age (AGA) and GDM/LGA. RESULTS: Overall, there were 62 102 deliveries, of which 53 201 (85...
November 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29139276/preventing-stroke-and-assessing-risk-in-women
#16
Tracey Keteepe-Arachi, Sanjay Sharma
Ischaemic stroke is rare in premenopausal women but risk increases with advancing age and doubles in the ten years following the menopause. Up to the age of 75 years men have a 25% higher risk of suffering a stroke compared with women. However, the increased life expectancy of women ultimately results in a higher overall incidence. Twice as many women die from stroke compare with breast cancer. Women with cerebrovascular disease are more likely to present with atypical symptoms than men. Altered mental status (including unresponsiveness, confusion and behavioural change) is the most common nonconventional symptom, and is reported by 23% of women compared with 15% of men...
March 2017: Practitioner
https://www.readbyqxmd.com/read/29138210/what-happens-after-menopause-wham-protocol-for-a-prospective-multicentre-age-matched-cohort-trial-of-risk-reducing-bilateral-salpingo-oophorectomy-in-high-risk-premenopausal-women
#17
Martha Hickey, Alison Trainer, Sabine Braat, Mary-Ann Davey, Efrosinia Krejany, John Wark
INTRODUCTION: Women at high inherited risk of ovarian cancer are advised to undergo risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 40-45 years or when their families are complete. Most women are premenopausal at this age, so RRBSO will induce surgical menopause. Despite the clear benefits of RRBSO for cancer risk reduction, much less is known about the impact on non-cancer outcomes that contribute to health and well-being and inform surveillance and management strategies...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29138200/assessing-the-consequences-of-gestational-diabetes-mellitus-on-offspring-s-cardiovascular-health-mysweetheart-cohort-study-protocol-switzerland
#18
Stefano Di Bernardo, Yvan Mivelaz, Adina Mihaela Epure, Yvan Vial, Umberto Simeoni, Pascal Bovet, Sandrine Estoppey Younes, Arnaud Chiolero, Nicole Sekarski
INTRODUCTION: Gestational diabetes mellitus (GDM) is a state of glucose intolerance with onset during pregnancy. GDM carries prenatal and perinatal risks as well as long-term risks for the mother and her child. GDM may be involved in the foetal programming of long-term cardiovascular health. However, evidence is sparse and the effect of GDM on cardiovascular health is unknown. To address these issues, we will conduct MySweetHeart Cohort study. The objectives are to assess the effect of GDM on offspring's cardiovascular health early in life by using surrogate markers of cardiovascular disease and atherosclerosis...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29137874/investigating-antenatal-nutrition-education-preferences-in-south-east-queensland-including-maori-and-pasifika-women
#19
Andrea Cruickshank, Helen E Porteous, Michelle A Palmer
BACKGROUND: Little is reported about the nutrition-related needs and preferences of women seeking maternity services, particularly Maori and Pasifika (M&P) women who have higher chronic disease rates in Queensland. AIM: Nutrition-related knowledge, needs, behaviours and education preferences were compared between women of M&P ancestry and non-Maori and Pasifika women (NMP). METHOD: Women (≥18 years) admitted to the postnatal ward were surveyed...
November 11, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29137463/normalized-weight-of-iranian-newborns-according-to-gestational-age-a-nationwide-study
#20
Soraya Saleh Gargari, Farahnaz Torkestani, Vahid Eidkhani, Afshin Amini, Ali Kabir
BACKGROUND: By organizing birth weights according to gestational age at birth, reference weight values for different sex-gestational ages are provided. METHODS: Data of 1,090,779 mothers and their neonates were gathered from 30 provinces of Iran. Pregnancy complications, maternal risk factors, type of delivery, maternal outcome, neonatal sex and APGAR score were determined. Birth weights were quantified into 3rd, 50th and 97th centile. Regression analysis was used to estimate birth weight of neonates...
October 2017: Archives of Iranian Medicine
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