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https://www.readbyqxmd.com/read/27871583/sugammadex-given-for-rocuronium-induced-neuromuscular-blockade-in-infants-a-retrospect%C3%A4-ve-study
#1
Ozlem Ozmete, Cagla Bali, Oya Yalcin Cok, Hatice Evren Eker Turk, Nesrın Bozdogan Ozyilkan, Soner Civi, Anıs Aribogan
STUDY OBJECTIVE: To evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients. DESIGN: Retrospective observational study. SETTING: University teaching hospital. PATIENTS: Twenty-six infants (2-12 months of age; 3-11 kg) with an American Society of Anesthesiologists classification I, II, or III who were scheduled to undergo neurosurgical procedures were included in the study...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27871504/efficacy-and-safety-of-sugammadex-compared-to-neostigmine-for-reversal-of-neuromuscular-blockade-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Michele Carron, Francesco Zarantonello, Paola Tellaroli, Carlo Ori
BACKGROUND AND OBJECTIVE: Sugammadex has been introduced for reversal of rocuronium (or vecuronium)-induced neuromuscular blockade (NMB). Although its efficacy has been established, data are conflicting whether it is safer than neostigmine traditionally used for reversing NMB. DESIGN: Meta-analysis of data about effectiveness and safety of sugammadex compared to neostigmine for reversing NMB in adults was performed using the PRISMA methodology. SETTING: University medical hospital...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27797097/neuromuscular-blockade-in-the-elderly
#3
Michał Stankiewicz-Rudnicki
The aim of the presented review is to highlight the clinical problem of postoperative residual curarization (PORC) following general anaesthesia in the elderly. Possible complications of PORC are described along with age-induced changes in pharmacokinetics of long and intermediate-acting neuromuscular blocking agents. This is intended to facilitate the selection and to promote appropriate intraoperative use of muscle relaxants in patients over the age of 65 years.
2016: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/27555126/recovery-of-laryngeal-nerve-function-with-sugammadex-after-rocuronium-induced-profound-neuromuscular-block
#4
Vittorio Pavoni, Lara Gianesello, Cristiana Martinelli, Andrew Horton, Alessandra Nella, Gabriele Gori, Martina Simonelli, Giuseppe De Scisciolo
STUDY OBJECTIVE: The aim of this study was to evaluate the efficacy of sugammadex in reversing profound rocuronium-induced neuromuscular block at the laryngeal adductor muscles using motor-evoked potentials (mMEPs). DESIGN: A prospective observational study. SETTING: University surgical center. PATIENTS: Twenty patients with American Society of Anesthesiologists physical class I-II status who underwent propofol-remifentanil anesthesia for the surgery of the thyroid gland...
September 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27403387/a-comparision-of-the-effect-of-sugammadex-on-the-recovery-period-and-postoperative-residual-block-in-young-elderly-and-middle-aged-elderly-patients
#5
Emine Yazar, Canan Yılmaz, Hülya Bilgin, Derya Karasu, Selcan Bayraktar, Yılmaz Apaydın, Halil Erkan Sayan
BACKGROUND: The importance of the characteristics of anesthesia and postoperative residual curarization (PORC) in the elderly population should be a growing concern in this century. AIMS: To investigate the effect of sugammadex on the duration of the recovery from neuromuscular blocking agents and postoperative residual curarization in the young elderly and middle-aged elderly patients who underwent elective laparoscopic cholecystectomy, followed by a train of four (TOF) watch monitorization...
March 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27387487/experimentalisierung-und-internationale-kommunikationen-der-fall-curare
#6
Marcus B Carrier
No abstract text is available yet for this article.
February 2016: Ambix
https://www.readbyqxmd.com/read/27335181/-the-failures-of-medicine
#7
EDITORIAL
Alberto Lifshitz
No abstract text is available yet for this article.
May 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27232277/residual-neuromuscular-blockade-in-the-postanesthesia-care-unit-observational-cross-sectional-study-of-a-multicenter-cohort
#8
Carlos L Errando, Ignacio Garutti, Guido Mazzinari, Oscar Diaz-Cambronero, John F Bebawy
BACKGROUND: Residual neuromuscular blockade after general anesthesia using nondepolarizing neuromuscular blocking agents has pathophysiological, clinical, and economic consequences. A significant number of patients under muscle relaxation sustain residual curarization. METHODS: Observational, prospective, multicenter study of a cohort of patients (Residual Curarization in Spain Study, ReCuSS). Residual blockade was defined as TOFr<0.9. Patients >18 years-old under general anesthesia, including at least one dose of non-depolarizing neuromuscular blocking agents, and transferred extubated and spontaneously ventilating to the postanesthesia care unit were included...
May 27, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27083225/-maxillo-facial-surgery-in-skeletal-class-ii-repercussions-on-the-temporo-mandibular-joints
#9
Armelle Manière-Ezvan, Charles Savoldelli, Floriant Busson, Arlette Oueiss, Jean-Daniel Orthlieb
These interventions usually aimed at the correction of the skeletal discrepancy by mandibular retrognatism with an advancement of the distal portion of the mandible after mandibular osteotomy. The position of the condyle is determined during the osteosynthesis with miniplates. Condyles are set back in relation with the supine position of the patient and the weakness of his (her) curarized muscle. All studies show that surgery of mandibular advancement causes a lateral, torque and backward movement of the condyles, all harmful to the condyles...
March 2016: L' Orthodontie Française
https://www.readbyqxmd.com/read/26937203/sugammadex-for-reversal-of-neuromuscular-blockade-a-retrospective-analysis-of-clinical-outcomes-and-cost-effectiveness-in-a-single-center
#10
Michele Carron, Fabio Baratto, Francesco Zarantonello, Carlo Ori
OBJECTIVE: The aim of the study is to evaluate the clinical and economic impact of introducing a rocuronium-neostigmine-sugammadex strategy into a cisatracurium-neostigmine regimen for neuromuscular block (NMB) management. METHODS: We conducted a retrospective analysis of clinical outcomes and cost-effectiveness in five operating rooms at University Hospital of Padova. A clinical outcome evaluation after sugammadex administration as first-choice reversal drug in selected patients (rocuronium-sugammadex) and as rescue therapy after neostigmine reversal (rocuronium-neostigmine-sugammadex) compared to control was performed...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/26820274/what-is-the-evidence-for-harm-of-neuromuscular-blockade-and-corticosteroid-use-in-the-intensive-care-unit
#11
Djillali Annane
Neuromuscular blocking agents and corticosteroids are widely used in medicine and in particular in the intensive care unit (ICU). Neuromuscular blockade is commonly used to ease tracheal intubation, to optimize mechanical ventilation and oxygenation in acute respiratory disorders such as status asthmaticus and acute respiratory distress syndrome (ARDS), to prevent shivering during therapeutic hypothermia, and also in patients with elevated intracranial pressure. In the ICU, patients with sepsis, ARDS, community-acquired pneumonia, exacerbation of chronic obstructive pulmonary disease, severe asthma, or trauma may receive corticosteroids...
February 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/26818254/developmental-nicotine-exposure-alters-cholinergic-control-of-respiratory-frequency-in-neonatal-rats
#12
Lila B Wollman, Jarl Haggerty, Jason Q Pilarski, Richard B Levine, Ralph F Fregosi
Prenatal nicotine exposure with continued exposure through breast milk over the first week of life (developmental nicotine exposure, DNE) alters the development of brainstem circuits that control breathing. Here, we test the hypothesis that DNE alters the respiratory motor response to endogenous and exogenous acetylcholine (ACh) in neonatal rats. We used the brainstem-spinal cord preparation in the split-bath configuration, and applied drugs to the brainstem compartment while measuring the burst frequency and amplitude of the fourth cervical ventral nerve roots (C4VR), which contain the axons of phrenic motoneurons...
October 2016: Developmental Neurobiology
https://www.readbyqxmd.com/read/26768931/survey-of-postoperative-residual-curarization-acute-respiratory-events-and-approach-of-anesthesiologists
#13
Ismail Aytac, Aysun Postaci, Betul Aytac, Ozlem Sacan, Gulcin Hilal Alay, Bulent Celik, Kadriye Kahveci, Bayazit Dikmen
BACKGROUND AND OBJECTIVES: residual paralysis following the use of neuromuscular blocking drugs (NMBDs) without neuromuscular monitoring remains a clinical problem, even when NMBDs are used. This study surveys postoperative residual curarization and critical respiratory events in the recovery room, as well as the clinical approach to PORC of anesthesiologists in our institution. METHODS: This observational study included 415 patients who received general anesthesia with intermediate-acting NMBDs...
January 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/26657094/the-middle-ear-muscle-reflex-in-the-diagnosis-of-cochlear-neuropathy
#14
Michelle D Valero, Kenneth E Hancock, M Charles Liberman
Cochlear neuropathy, i.e. the loss of auditory nerve fibers (ANFs) without loss of hair cells, may cause hearing deficits without affecting threshold sensitivity, particularly if the subset of ANFs with high thresholds and low spontaneous rates (SRs) is preferentially lost, as appears to be the case in both aging and noise-damaged cochleas. Because low-SR fibers may also be important drivers of the medial olivocochlear reflex (MOCR) and middle-ear muscle reflex (MEMR), these reflexes might be sensitive metrics of cochlear neuropathy...
February 2016: Hearing Research
https://www.readbyqxmd.com/read/26508869/feasibility-of-full-and-rapid-neuromuscular-blockade-recovery-with-sugammadex-in-myasthenia-gravis-patients-undergoing-surgery-a-series-of-117-cases
#15
Tomas Vymazal, Martina Krecmerova, Vladimír Bicek, Robert Lischke
PURPOSE: Myasthenia gravis (MG) is an autoimmune disease interfering with neuromuscular transmission. Patients are at risk of postoperative residual curarization (PORC) if nondepolarizing muscle relaxants are used. Clinically inapparent insufficient muscle strength may result in hypoventilation and postoperative bronchopneumonia. We describe a cohort of 117 cases in which sugammadex was used in MG patients undergoing surgery with muscle relaxation with rocuronium. METHODS AND PATIENTS: We anesthetized 117 patients with MG using rocuronium and sugammadex as neuromuscular blockade reversal agent...
2015: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/26472231/prospective-study-of-residual-neuromuscular-block-and-postoperative-respiratory-complications-in-patients-reversed-with-neostigmine-versus-sugammadex
#16
Javier Martinez-Ubieto, Sonia Ortega-Lucea, Ana Pascual-Bellosta, Ivan Arazo-Iglesias, Jesús Gil-Bona, Teresa Jimenez-Bernardó, Luis Muñoz-Rodriguez
BACKGROUND: Postoperative residual curarization (PORC) is an important complication of neuromuscular blocking drug (NMBD) use. This study evaluates the incidence of PORC in the Postanesthesia Care Unit (PACU), its relation to the type of muscle relaxant and reversal agent used, and its implication in the development of postoperative respiratory complications. METHODS: A prospective observational study of cohorts was made with 558 patients operated under general anesthesia...
July 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/26323727/use-of-neuromuscular-blockers-in-brazil
#17
Giovani de Figueiredo Locks, Ismar Lima Cavalcanti, Nadia Maria Conceição Duarte, Rafael Martins da Cunha, Maria Cristina Simões de Almeida
The objective of this study was to evaluate how Brazilian anesthesiologists are using neuromuscular blockers, focusing on how they establish the diagnosis of postoperative residual curarization and the incidence of complications associated with the use of neuromuscular blockers. A questionnaire was sent to anesthesiologists inviting them to participate in the study. The online data collection remained open from March 2012 to June 2013. During the study period, 1296 responses were collected. Rocuronium, atracurium, and cisatracurium were the main neuromuscular blockers used in cases of elective surgery...
September 2015: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/26165127/-curare-like-camphor-derivatives-and-their-biological-activity
#18
A S Sokolova, E A Morozova, V G Vasilev, O I Yarovaya, T G Tolstikova, N F Salakhutdinov
The synthesis and evaluation of muscle relaxant activity of series of dimeric camphor derivatives are described. Compounds in which the quaternary nitrogen atoms are separated by aromatic chain exhibited the highest efficiency as muscle relaxant. It was shown the screening of a charged atom and counter-ion does not have a significant role on the activity of the studied agents.
March 2015: Bioorganicheskaia Khimiia
https://www.readbyqxmd.com/read/26160689/serial-elongation-derotation-and-flexion-edf-casting-under-general-anesthesia-and-neuromuscular-blocking-drugs-improve-outcome-in-patients-with-juvenile-scoliosis-preliminary-results
#19
COMPARATIVE STUDY
Federico Canavese, Alexei Botnari, Alain Dimeglio, Antoine Samba, Bruno Pereira, Adeline Gerst, Marie Granier, Marie Rousset, Jean Dubousset
PURPOSE: Juvenile scoliosis (JS), among different types of spinal deformity, remains still a challenge for orthopedic surgeons. Elongation, derotation and flexion (EDF) casting technique is a custom-made thoracolumbar cast based on a three-dimensional correction concept. The primary objective of the present study was to measure changes on plain radiographs of patients with JS treated with EDF plaster technique. The second aim was to evaluate the effectiveness of the EDF plaster technique realized under general anesthesia (GA) and neuromuscular blocking drugs, i...
February 2016: European Spine Journal
https://www.readbyqxmd.com/read/26160168/-use-of-neuromuscular-blockers-in-brazil
#20
Giovani de Figueiredo Locks, Ismar Lima Cavalcanti, Nadia Maria Conceição Duarte, Rafael Martins da Cunha, Maria Cristina Simões de Almeida
The objective of this study was to evaluate how Brazilian anesthesiologists are using neuromuscular blockers (NMB), focusing on how they establish the diagnosis of postoperative residual curarization and the incidence of complications associated with the use of NMB. A questionnaire was sent to anesthesiologists inviting them to participate in the study. The online data collection remained open from March 2012 to June 2013. During the study period, 1296 responses were collected. Rocuronium, atracurium, and cisatracurium were the main neuromuscular blockers used in cases of elective surgery...
September 2015: Revista Brasileira de Anestesiologia
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