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Benjamin J Shore, Benjamin G Allar, Patricia E Miller, Travis H Matheney, Brian D Snyder, Maria A Fragala-Pinkham
Background: The PEDI-CAT is a new clinical assessment for children and youth from birth through 20 years of age. Objective: To determine the discriminant validity of the PEDI-CAT according to Gross Motor Function Classification System (GMFCS) and Manual Ability Classification System (MACS) in children with cerebral palsy (CP). Design: A prospective convenience cross-sectional sample of 101 school-aged children with CP was stratified by GMFCS level...
March 31, 2017: Physical Therapy
William H DuPont, William J Kraemer, Bradley C Nindl, Elaine C Lee, Maren S Fragala, Disa L Hatfield, Lydia K Caldwell, Emily M Post, Matthew K Beeler, Jeff S Volek, Carl M Maresh
Due to the important interactions of proenkephalin fragments (e.g., proenkephalin [107-140] Peptide F) to enhance activation of immune cells and potentially combat pain associated with exercise-induced muscle tissue damage, we examined the differential plasma responses of Peptide F to different exercise training programs. Participants were tested pre-training (T1), and after 8 weeks (T2) of training. Fifty-nine healthy women were matched and then randomly assigned to one of four groups: heavy resistance strength training (STR, n=18), high intensity endurance training (END, n=14), combined strength and endurance training (CMB, n=17), or control (CON, n=10)...
March 3, 2017: Peptides
Rosaly Correa-de-Araujo, Michael O Harris-Love, Iva Miljkovic, Maren S Fragala, Brian W Anthony, Todd M Manini
A growing body of scientific literature suggests that not only changes in skeletal muscle mass, but also other factors underpinning muscle quality, play a role in the decline in skeletal muscle function and impaired mobility associated with aging. A symposium on muscle quality and the need for standardized assessment was held on April 28, 2016 at the International Conference on Frailty and Sarcopenia Research in Philadelphia, Pennsylvania. The purpose of this symposium was to provide a venue for basic science and clinical researchers and expert clinicians to discuss muscle quality in the context of skeletal muscle function deficit and other aging-related muscle dysfunctions...
2017: Frontiers in Physiology
Helene M Dumas, Maria A Fragala-Pinkham, Elaine L Rosen, Eric Folmar
PURPOSE: To examine differences in physical therapy dosing frequency recommendations based on children's characteristics and to describe types of intervention recommended at postacute hospital admission. METHODS: Demographic and clinical information, recommended physical therapy intervention frequency, and intervention types were collected for all admissions from April 1, 2015, to March 1, 2016. Differences across 2 groups, children with recommendations for "less" (≤3x/wk) or "more" (≥4x/wk) frequent therapy, were examined...
January 2017: Pediatric Physical Therapy
Meysam Roostaei, Hamzeh Baharlouei, Hamidreza Azadi, Maria A Fragala-Pinkham
AIMS: To review the literature on the effects of aquatic intervention on gross motor skills for children with cerebral palsy (CP). DATA SOURCES: Six databases were searched from inception to January 2016. REVIEW METHODS: Aquatic studies for children aged 1-21 years with any type or CP classification and at least one outcome measuring gross motor skills were included. Information was extracted on study design, outcomes, and aquatic program type, frequency, duration, and intensity...
December 14, 2016: Physical & Occupational Therapy in Pediatrics
Giuseppe Trusso Sfrazzetto, Salvatrice Millesi, Andrea Pappalardo, Gaetano A Tomaselli, Francesco P Ballistreri, Rosa Maria Toscano, Ignazio Fragalà, Antonino Gulino
A uranyl complex monolayer that easily allows the optical detection of a nerve gas simulant, namely, dimethyl methylphosphonate, is reported. Both UV/Vis spectroscopy and photoelectron data confirm that the functional hybrid material coordinates a Lewis base by means of the P=O group, which interacts with the uranium equatorial site available for complexation.
January 31, 2017: Chemistry: a European Journal
Helene M Dumas, Maria A Fragala-Pinkham, Elaine L Rosen, Jane E O'Brien
PURPOSE: To assess construct (convergent and divergent) validity of the Pediatric Evaluation of Disability Inventory Computer Adaptive Test (PEDI-CAT) in a sample of children with complex medical conditions. METHOD: Demographics, clinical information, PEDI-CAT normative score, and the Post-Acute Acuity Rating for Children (PAARC) level were collected for all post-acute hospital admissions (n = 110) from 1 April 2015 to 1 March 2016. Correlations between the PEDI-CAT Daily Activities, Mobility, and Social/Cognitive domain scores for the total sample and across three age groups (infant, preschool, and school-age) were calculated...
September 19, 2016: Disability and Rehabilitation
Maria A Fragala-Pinkham, Helene M Dumas, Kelly A Lombard, Jane E O'Brien
PURPOSE: Responsiveness of the PEDI-CAT Mobility, Daily Activities, and Social/Cognitive domains and Wheelchair subdomain was evaluated for youth admitted to a pediatric post-acute care hospital. METHODS: Inpatients ages 2-21 years, with a length of stay of ≥ 5 days and with both admission and discharge scores were included. The difference between mean admission and discharge PEDI-CAT scaled scores were analyzed using paired t-tests. Effect sizes, standard response means (SRMs), and minimal detectable change values were calculated...
September 2, 2016: Journal of Pediatric Rehabilitation Medicine
Simona Filice, Giuseppe Compagnini, Roberto Fiorenza, Salvatore Scirè, Luisa D'Urso, Maria Elena Fragalà, Paola Russo, Enza Fazio, Silvia Scalese
We have measured the photocatalytic water splitting activity of several titania colloids, modified by nanosecond pulsed laser irradiation. Photocatalysis has been tested using UV and visible light. We have found that laser irradiation increases the hydrogen production efficiency up to a factor of three for anatase, rutile and P25. A hydrogen production rate as high as 30mmolg(-1)h(-1) has been obtained with good stability, tested by repeated runs. The chemical and morphological properties of the nanoparticles have been studied by electron microscopy, X-ray photoelectron spectroscopy and Raman spectroscopy, showing that laser irradiation promotes the formation of disordered surface state and lattice distortion which could be responsible for the observed enhanced photocatalytic activity...
March 1, 2017: Journal of Colloid and Interface Science
A Di Mauro, R Randazzo, S F Spanò, G Compagnini, M Gaeta, L D'Urso, R Paolesse, G Pomarico, C Di Natale, V Villari, N Micali, M E Fragalà, A D'Urso, R Purrello
Graphene oxide (GO) is one of the most appealing bidimensional materials able to interact non-covalently with achiral molecules and to act as chiral inducers. Vortexes can tune chirality and, consequently transfer a specific handedness to non-covalent host molecules, either when dispersed in water or when deposited on a solid surface.
August 23, 2016: Chemical Communications: Chem Comm
Massimiliano Gaeta, Ivan Pietro Oliveri, Maria Elena Fragalà, Salvatore Failla, Alessandro D'Urso, Santo Di Bella, Roberto Purrello
Herein, we exploit the induction of chirality by chiral Zn(ii) Schiff-base complexes, followed by their spontaneous dissociation in aqueous solution, providing for the first time a possibility of overcoming the template removal steps, to demonstrate memorization of chirality in porphyrin hetero-aggregates.
June 30, 2016: Chemical Communications: Chem Comm
Tommaso Castelli, Giorgio Ivan Russo, Giulio Reale, Salvatore Privitera, Mario Chisari, Eugenia Fragalà, Vincenzo Favilla, Sebastiano Cimino, Giuseppe Morgia
Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels...
May 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Andrea Baglieri, Sarah Sidella, Valeria Barone, Ferdinando Fragalà, Alla Silkina, Michèle Nègre, Mara Gennari
This work evaluates the possibility of cultivating Scenedesmus quadricauda and Chlorella vulgaris microalgae in wastewater from the hydroponic cultivation of tomatoes with the aim of purifying the water. S. quadricauda and C. vulgaris were also used in purification tests carried out on water contaminated by the following active ingredients: metalaxyl, pyrimethanil, fenhexamid, iprodione, and triclopyr. Fifty-six days after the inoculum was placed, a reduction was found in the concentration of nitric nitrogen, ammonia nitrogen, and soluble and total phosphorus...
September 2016: Environmental Science and Pollution Research International
Guy Fragala
In recent years, safe patient handling in the health care industry has been addressed by various stakeholders, but much work remains to reduce health care worker injuries, and improve safety and care quality for patients. Recently, safe patient handling in ambulatory care settings has gained attention. As health care delivery evolves, demands on ambulatory care will increase and more dependent patients will visit ambulatory care clinics. Typically, ambulatory care clinics are not equipped with appropriate safe patient handling equipment...
September 2016: Workplace Health & Safety
Amy Pasternak, Georgios Sideridis, Maria Fragala-Pinkham, Allan M Glanzman, Jacqueline Montes, Sally Dunaway, Rachel Salazar, Janet Quigley, Shree Pandya, Susan O'Riley, Jonathan Greenwood, Claudia Chiriboga, Richard Finkel, Gihan Tennekoon, William B Martens, Michael P McDermott, Heather Szelag Fournier, Lavanya Madabusi, Timothy Harrington, Rosangel E Cruz, Nicole M LaMarca, Nancy M Videon, Darryl C De Vivo, Basil T Darras
INTRODUCTION: In this study we evaluated the suitability of a caregiver-reported functional measure, the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT), for children and young adults with spinal muscular atrophy (SMA). METHODS: PEDI-CAT Mobility and Daily Activities domain item banks were administered to 58 caregivers of children and young adults with SMA. Rasch analysis was used to evaluate test properties across SMA types. RESULTS: Unidimensional content for each domain was confirmed...
December 2016: Muscle & Nerve
Ruth A Crowley, Helene M Dumas, Maria A Fragala-Pinkham, Donald N Dougherty, Ellen M Hull, Mary Laurette Hughes, Eric Hsaio
VerbalCare is a mobile software platform for hospital patients and nursing staff to communicate in real-time. The purposes of this study were to (1) identify and evaluate icons for the VerbalCare tablet application and (2) examine use and satisfaction with this tablet application in a paediatric post-acute hospital. Hospital nursing staff were surveyed to identify the most common reasons children use the "nursing call bell". Icons for the VerbalCare tablet application were developed to match the identified call bell requests and be understood by children...
April 21, 2016: Disability and Rehabilitation. Assistive Technology
Santo Fragalà, Pietro Medica, Francesco Grande, Irene Vazzana, Esterina Fazio
AIM: The purpose of the research was to test and validate an innovative and safe chemiluminescence method to evaluate sexual hormones in serum and plasma samples of Tursiops truncatus. MATERIALS AND METHODS: The research was performed on 9 bottlenose dolphins entertained in Oltremare and in Zoomarine aquatic parks, sampled by the tail vein or from the ventral one and an ultrasound monitoring, throughout a 6 months period. Blood samples were analyzed using a chemiluminescence method...
August 2015: Veterinary World
Oriana Ciani, Erik Arendsen, Martin Romancik, Richard Lunik, Elisabetta Costantini, Manuel Di Biase, Giuseppe Morgia, Eugenia Fragalà, Tomaskin Roman, Marian Bernat, Giorgio Guazzoni, Rosanna Tarricone, Massimo Lazzeri
OBJECTIVES: To compare the clinical effectiveness of the intravesical administration of combined hyaluronic acid and chondroitin sulfate (HA+CS) versus current standard management in adult women with recurrent urinary tract infections (RUTIs). SETTING: A European Union-based multicentre, retrospective nested case-control study. PARTICIPANTS: 276 adult women treated for RUTIs starting from 2009 to 2013. INTERVENTIONS: Patients treated with either intravesical administration of HA+CS or standard of care (antimicrobial/immunoactive prophylaxis/probiotics/cranberry)...
March 31, 2016: BMJ Open
Maren S Fragala, Dawn E Alley, Michelle D Shardell, Tamara B Harris, Robert R McLean, Douglas P Kiel, Peggy M Cawthon, Thuy-Tien L Dam, Luigi Ferrucci, Jack M Guralnik, Stephen B Kritchevsky, Maria T Vassileva, Vilmunder Gudnason, Gudny Eiriksdottir, Annemarie Koster, Anne Newman, Kristin Siggeirsdottir, Suzanne Satterfield, Stephanie A Studenski, Anne M Kenny
OBJECTIVES: To compare the relative predictive power of handgrip and leg extension strength in predicting slow walking. DESIGN: Report of correlative analysis from two epidemiological cohort studies. SETTING: Foundation of the National Institutes of Health Sarcopenia Project. PARTICIPANTS: Men and women aged 67 to 93 (N=6,766). MEASUREMENTS: Leg strength, handgrip strength, and gait speed were measured...
January 2016: Journal of the American Geriatrics Society
Eugenia Fragalà, Giorgio Ivan Russo, Alessandro Di Rosa, Raimondo Giardina, Salvatore Privitera, Vincenzo Favilla, Francesco Patti, Blayne Welk, Sebastiano Cimino, Tommaso Castelli, Giuseppe Morgia
PURPOSE: To determine the relationship between the neurogenic bladder symptoms score (NBSS) and urodynamic examination in patients affected by multiple sclerosis (MS) and related lower urinary tract dysfunction (LUTD). METHODS: We recruited 122 consecutive patients with MS in remission and LUTD from January 2011 to September 2013 who underwent their first urodynamic examination. Neurological impairment was assessed using the Expanded Disability Status Scale (EDSS) and bladder symptoms were studied with the NBSS...
December 2015: International Neurourology Journal
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