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Helene M Dumas, Maria A Fragala-Pinkham, Elaine L Rosen, Jane E O'Brien
PURPOSE: To assess construct (convergent and divergent) validity of the Pediatric Evaluation of Disability Inventory Computer Adaptive Test (PEDI-CAT) in a sample of children with complex medical conditions. METHOD: Demographics, clinical information, PEDI-CAT normative score, and the Post-Acute Acuity Rating for Children (PAARC) level were collected for all post-acute hospital admissions (n = 110) from 1 April 2015 to 1 March 2016. Correlations between the PEDI-CAT Daily Activities, Mobility, and Social/Cognitive domain scores for the total sample and across three age groups (infant, preschool, and school-age) were calculated...
September 19, 2016: Disability and Rehabilitation
Maria A Fragala-Pinkham, Helene M Dumas, Kelly A Lombard, Jane E O'Brien
PURPOSE: Responsiveness of the PEDI-CAT Mobility, Daily Activities, and Social/Cognitive domains and Wheelchair subdomain was evaluated for youth admitted to a pediatric post-acute care hospital. METHODS: Inpatients ages 2-21 years, with a length of stay of ≥ 5 days and with both admission and discharge scores were included. The difference between mean admission and discharge PEDI-CAT scaled scores were analyzed using paired t-tests. Effect sizes, standard response means (SRMs), and minimal detectable change values were calculated...
September 2, 2016: Journal of Pediatric Rehabilitation Medicine
Simona Filice, Giuseppe Compagnini, Roberto Fiorenza, Salvatore Scirè, Luisa D'Urso, Maria Elena Fragalà, Paola Russo, Enza Fazio, Silvia Scalese
We have measured the photocatalytic water splitting activity of several titania colloids, modified by nanosecond pulsed laser irradiation. Photocatalysis has been tested using UV and visible light. We have found that laser irradiation increases the hydrogen production efficiency up to a factor of three for anatase, rutile and P25. A hydrogen production rate as high as 30mmolg(-1)h(-1) has been obtained with good stability, tested by repeated runs. The chemical and morphological properties of the nanoparticles have been studied by electron microscopy, X-ray photoelectron spectroscopy and Raman spectroscopy, showing that laser irradiation promotes the formation of disordered surface state and lattice distortion which could be responsible for the observed enhanced photocatalytic activity...
August 5, 2016: Journal of Colloid and Interface Science
A Di Mauro, R Randazzo, S F Spanò, G Compagnini, M Gaeta, L D'Urso, R Paolesse, G Pomarico, C Di Natale, V Villari, N Micali, M E Fragalà, A D'Urso, R Purrello
Graphene oxide (GO) is one of the most appealing bidimensional materials able to interact non-covalently with achiral molecules and to act as chiral inducers. Vortexes can tune chirality and, consequently transfer a specific handedness to non-covalent host molecules, either when dispersed in water or when deposited on a solid surface.
August 23, 2016: Chemical Communications: Chem Comm
Massimiliano Gaeta, Ivan Pietro Oliveri, Maria Elena Fragalà, Salvatore Failla, Alessandro D'Urso, Santo Di Bella, Roberto Purrello
Herein, we exploit the induction of chirality by chiral Zn(ii) Schiff-base complexes, followed by their spontaneous dissociation in aqueous solution, providing for the first time a possibility of overcoming the template removal steps, to demonstrate memorization of chirality in porphyrin hetero-aggregates.
June 30, 2016: Chemical Communications: Chem Comm
Tommaso Castelli, Giorgio Ivan Russo, Giulio Reale, Salvatore Privitera, Mario Chisari, Eugenia Fragalà, Vincenzo Favilla, Sebastiano Cimino, Giuseppe Morgia
Benign prostatic hyperplasia and prostate cancer are two common urological diseases of the elderly. Scientific community has always looked for a link that could explain the correlation between the two diseases and the role of chronic inflammation in the pathogenesis of BPH and PCa. As shown by the reports of the two diseases relationship with oxidative stress and metabolic syndrome, the use of compounds with antioxidant action could therefore affect both the symptoms and their onset. Polyphenols appear to act not only against oxidative stress but also at different levels...
May 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Andrea Baglieri, Sarah Sidella, Valeria Barone, Ferdinando Fragalà, Alla Silkina, Michèle Nègre, Mara Gennari
This work evaluates the possibility of cultivating Scenedesmus quadricauda and Chlorella vulgaris microalgae in wastewater from the hydroponic cultivation of tomatoes with the aim of purifying the water. S. quadricauda and C. vulgaris were also used in purification tests carried out on water contaminated by the following active ingredients: metalaxyl, pyrimethanil, fenhexamid, iprodione, and triclopyr. Fifty-six days after the inoculum was placed, a reduction was found in the concentration of nitric nitrogen, ammonia nitrogen, and soluble and total phosphorus...
September 2016: Environmental Science and Pollution Research International
Guy Fragala
In recent years, safe patient handling in the health care industry has been addressed by various stakeholders, but much work remains to reduce health care worker injuries, and improve safety and care quality for patients. Recently, safe patient handling in ambulatory care settings has gained attention. As health care delivery evolves, demands on ambulatory care will increase and more dependent patients will visit ambulatory care clinics. Typically, ambulatory care clinics are not equipped with appropriate safe patient handling equipment...
September 2016: Workplace Health & Safety
Amy Pasternak, Georgios Sideridis, Maria Fragala-Pinkham, Allan M Glanzman, Jacqueline Montes, Sally Dunaway, Rachel Salazar, Janet Quigley, Shree Pandya, Susan O'Riley, Jonathan Greenwood, Claudia Chiriboga, Richard Finkel, Gihan Tennekoon, William B Martens, Michael P McDermott, Heather Szelag Fournier, Lavanya Madabusi, Timothy Harrington, Rosangel E Cruz, Nicole M LaMarca, Nancy M Videon, Darryl C De Vivo, Basil T Darras
PURPOSE: We evaluated the suitability of a caregiver-reported functional measure, the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test (PEDI-CAT), for children and young adults with spinal muscular atrophy (SMA). METHODS: PEDI-CAT Mobility and Daily Activities domain item banks were administered to 58 caregivers of children and young adults with SMA. Rasch analysis was used to evaluate test properties across SMA types. RESULTS: Unidimensional content for each domain was confirmed...
April 27, 2016: Muscle & Nerve
Ruth A Crowley, Helene M Dumas, Maria A Fragala-Pinkham, Donald N Dougherty, Ellen M Hull, Mary Laurette Hughes, Eric Hsaio
VerbalCare is a mobile software platform for hospital patients and nursing staff to communicate in real-time. The purposes of this study were to (1) identify and evaluate icons for the VerbalCare tablet application and (2) examine use and satisfaction with this tablet application in a paediatric post-acute hospital. Hospital nursing staff were surveyed to identify the most common reasons children use the "nursing call bell". Icons for the VerbalCare tablet application were developed to match the identified call bell requests and be understood by children...
April 21, 2016: Disability and Rehabilitation. Assistive Technology
Santo Fragalà, Pietro Medica, Francesco Grande, Irene Vazzana, Esterina Fazio
AIM: The purpose of the research was to test and validate an innovative and safe chemiluminescence method to evaluate sexual hormones in serum and plasma samples of Tursiops truncatus. MATERIALS AND METHODS: The research was performed on 9 bottlenose dolphins entertained in Oltremare and in Zoomarine aquatic parks, sampled by the tail vein or from the ventral one and an ultrasound monitoring, throughout a 6 months period. Blood samples were analyzed using a chemiluminescence method...
August 2015: Veterinary World
Oriana Ciani, Erik Arendsen, Martin Romancik, Richard Lunik, Elisabetta Costantini, Manuel Di Biase, Giuseppe Morgia, Eugenia Fragalà, Tomaskin Roman, Marian Bernat, Giorgio Guazzoni, Rosanna Tarricone, Massimo Lazzeri
OBJECTIVES: To compare the clinical effectiveness of the intravesical administration of combined hyaluronic acid and chondroitin sulfate (HA+CS) versus current standard management in adult women with recurrent urinary tract infections (RUTIs). SETTING: A European Union-based multicentre, retrospective nested case-control study. PARTICIPANTS: 276 adult women treated for RUTIs starting from 2009 to 2013. INTERVENTIONS: Patients treated with either intravesical administration of HA+CS or standard of care (antimicrobial/immunoactive prophylaxis/probiotics/cranberry)...
2016: BMJ Open
Maren S Fragala, Dawn E Alley, Michelle D Shardell, Tamara B Harris, Robert R McLean, Douglas P Kiel, Peggy M Cawthon, Thuy-Tien L Dam, Luigi Ferrucci, Jack M Guralnik, Stephen B Kritchevsky, Maria T Vassileva, Vilmunder Gudnason, Gudny Eiriksdottir, Annemarie Koster, Anne Newman, Kristin Siggeirsdottir, Suzanne Satterfield, Stephanie A Studenski, Anne M Kenny
OBJECTIVES: To compare the relative predictive power of handgrip and leg extension strength in predicting slow walking. DESIGN: Report of correlative analysis from two epidemiological cohort studies. SETTING: Foundation of the National Institutes of Health Sarcopenia Project. PARTICIPANTS: Men and women aged 67 to 93 (N=6,766). MEASUREMENTS: Leg strength, handgrip strength, and gait speed were measured...
January 2016: Journal of the American Geriatrics Society
Eugenia Fragalà, Giorgio Ivan Russo, Alessandro Di Rosa, Raimondo Giardina, Salvatore Privitera, Vincenzo Favilla, Francesco Patti, Blayne Welk, Sebastiano Cimino, Tommaso Castelli, Giuseppe Morgia
PURPOSE: To determine the relationship between the neurogenic bladder symptoms score (NBSS) and urodynamic examination in patients affected by multiple sclerosis (MS) and related lower urinary tract dysfunction (LUTD). METHODS: We recruited 122 consecutive patients with MS in remission and LUTD from January 2011 to September 2013 who underwent their first urodynamic examination. Neurological impairment was assessed using the Expanded Disability Status Scale (EDSS) and bladder symptoms were studied with the NBSS...
December 2015: International Neurourology Journal
Alessandro Di Mauro, Massimo Zimbone, Mario Scuderi, Giuseppe Nicotra, Maria Elena Fragalà, Giuliana Impellizzeri
For this study, we originally realized ZnO nanofibers (∼50 nm in mean radius) mixed with Pt nanoparticles (∼30 nm in mean radius), prepared by pulsed laser ablation in liquid, and investigated their photocatalytic performance. The material was synthesized by the simple electrospinning method coupled with subsequent thermal treatments. Methylene blue was employed as a representative dye pollutant to evaluate the photocatalytic activity of the nanofibers. It was found that the Pt-ZnO fibers exhibit a photodegradation reaction rate that is ∼40 % higher than the one obtained for reference ZnO fibers...
December 2015: Nanoscale Research Letters
Stewart G Trost, Maria Fragala-Pinkham, Nancy Lennon, Margaret E O'Neil
PURPOSE: To develop and test decision tree (DT) models to classify physical activity (PA) intensity from accelerometer output and Gross Motor Function Classification System (GMFCS) classification level in ambulatory youth with cerebral palsy (CP) and compare the classification accuracy of the new DT models to that achieved by previously published cut points for youth with CP. METHODS: Youth with CP (GMFCS levels I-III) (N = 51) completed seven activity trials with increasing PA intensity while wearing a portable metabolic system and ActiGraph GT3X accelerometers...
May 2016: Medicine and Science in Sports and Exercise
Vincenzo M Altieri, Barbara Altieri, Roberto Castellucci, Stefano Alba, Francesco Bottone, Eugenia Fragalà, Vincenzo Mirone, Francesco Greco
CONTEXT: Male patients with congenital adrenal hyperplasia (CAH) may develop bilateral testicular adrenal rest tumours (TARTs). These tumours, in most cases, regress with glucocorticoid therapy and their histological differentiation from Leydig-cell tumors is quite difficult. OBJECTIVE: The aim of this study was to differentiate the histological and clinical features of the TARTs from those of the Leydig-cell tumours. METHODS: The authors report a case of bilateral Leydig-cell tumour associated with giant bilateral adrenal myelolipoma in a male with adrenogenital syndrome who was submitted to a bilateral orchiectomy...
March 5, 2016: Urologia
Jonathan D Bohner, Jay R Hoffman, William P McCormack, Tyler C Scanlon, Jeremy R Townsend, Jeffrey R Stout, Maren S Fragala, David H Fukuda
The effect of altitude on soccer game activity profiles was retrospectively examined in six NCAA Division I female soccer players. Comparisons were made between two matches played at sea level (SL) and one match played at a moderate altitude (1839 m). A 10-Hz global positioning system device was used to measure distance and velocity. The rate of total distance capacity (TDC) and high intensity running (HIR) as well as percent of time at HIR were evaluated. Significant differences were seen in the distance rate (120...
September 29, 2015: Journal of Human Kinetics
Kyle S Beyer, David H Fukuda, Carleigh H Boone, Adam J Wells, Jeremy R Townsend, Adam R Jajtner, Adam M Gonzalez, Maren S Fragala, Jay R Hoffman, Jeffrey R Stout
Short-term unilateral resistance training results in cross education of strength without changes in muscle size, activation, or endocrine response. J Strength Cond Res 30(5): 1213-1223, 2016-The purpose of this study was to assess the cross education of strength and changes in the underlying mechanisms (muscle size, activation, and hormonal response) after a 4-week unilateral resistance training (URT) program. A group of 9 untrained men completed a 4-week URT program on the dominant leg (DOM), whereas cross education was measured in the nondominant leg (NON); and were compared with a control group (n = 8, CON)...
May 2016: Journal of Strength and Conditioning Research
Jeremy R Townsend, Jay R Hoffman, Maren S Fragala, Leonardo P Oliveira, Adam R Jajtner, David H Fukuda, Jeffrey R Stout
INTRODUCTION: The fine aspiration microbiopsy is a relatively new biopsy technique, which allows muscle physiologists to sample skeletal muscle less invasively. However, the small sample size obtained is often deemed insufficient for certain analyses. The aim of the current study was to develop procedures for muscle fiber morphology and immunohistological analysis from a microbiopsy technique. METHODS: Microbiopsies of the vastus lateralis were taken with a 14-gauge microbiopsy needle from four healthy men on two separate occasions...
February 2016: Medicine and Science in Sports and Exercise
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