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https://www.readbyqxmd.com/read/28945035/-preliminary-research-on-effect-of-licorice-processed-tripterygium-wilfordii-on-reducing-liver-toxicity
#1
Xiao-Mei Zhao, Man Gong, Jie-Ming Dong, Jia-Bo Wang, Xiao-He Xiao, Kui-Jun Zhao, Zhi-Jie Ma
To explore the effect of the licorice-processed Tripterygium wilfordii on reducing the liver toxicity. In animal experiments, the liver toxicity of T. wilfordii was evaluated both before and after processing, and the differences in liver tissue biopsy, serum biochemical indexes and inflammatory cell factor among blank group, T. wilfordii group and licorice-processed T. wilfordii group were observed. Liver tissue biopsy results showed that liver tissue injury was obvious in T. wilfordii group, and no obvious injury was found in licorice-processed T...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945018/-expert-consensus-on-the-design-and-implementation-of-clinical-safety-centralized-monitoring-study-of-chinese-medical-injection
#2
Jun-Hua Zhang, Jing-Tian Ren, Jing-Qing Hu, Yan-Ming Xie, Hai-Bo Song, Ming-Jun Zhu, Rui Gao, Zhong Wang, Wen-Ke Zheng, Xue-Lin Li, Meng Jiang, Yu-Hong Huang, Fang Lu, Li-Yun He, Wei-Xiong Lian, Zhong-Qi Yang, Wei-An Yuan, Si-Yuan Hu, Bao-He Wang, Wei-Liang Wang, De-Quan Ren, Bo-Li Zhang
Along with the increase of clinical application, the safety of traditional Chinese medicine gained more and more attentions. In particular, the safety evaluation of Chinese medical injections has become a mandatory task should be completed by pharmaceutical companies under the supervision of China Food and Drug Administration(CFDA). Due to the weak foundation of previous studies, the safety issues of Chinese medical injections have not been fully understood, and lack of scientific and rational risk management programs...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945011/prediction-of-drug-drug-interaction-between-tacrolimus-and-principal-ingredients-of-wuzhi-capsule-in-chinese-healthy-volunteers-using-physiologically-based-pharmacokinetic-modelling
#3
Hongyan Zhang, Fengjiao Bu, Lei Li, Zheng Jiao, Guo Ma, Weimin Cai, Xiaomei Zhuang, Hai-Shu Lin, Jae-Gook Shin, Xiaoqiang Xiang
Schisantherin A and schisandrin A, the most abundant active ingredients of Wuzhi capsule, are known to inhibit tacrolimus metabolism by inhibiting CYP3A4/5. We aimed to predict the contribution of schisantherin A and schisandrin A to drug-drug interaction (DDI) between Wuzhi capsule and tacrolimus using physiologically-based pharmacokinetic (PBPK) modelling. Firstly, the inhibition mechanism of schisantherin A and schisandrin A on CYP3A4/5 were investigated. Thereafter, PBPK models of schisantherin A, schisandrin A and tacrolimus were established...
September 25, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28944795/on-the-viability-of-mg-extraction-in-mgmon2-a-combined-experimental-and-theoretical-approach
#4
R Verrelli, M E Arroyo-de-Dompablo, D Tchitchekova, A P Black, C Frontera, A Fuertes, M R Palacin
Layered MgMoN2 was prepared by solid state reaction at high temperature between Mo and Mg3N2 in N2 which represents a simple synthetic pathway compared to the previously reported method that used NaN3 as the nitrogen source. The crystal structure of MgMoN2 was studied by synchrotron X-ray and neutron powder diffraction. The feasibility of oxidizing this compound and concomitantly extracting magnesium from the structure was assessed by both chemical and electrochemical approaches, using different protocols. The X-ray diffraction patterns of the oxidized samples do not exhibit any relevant difference with respect to that of the as prepared MgMoN2 and no differences in the cell parameters are deduced from Rietveld refinements...
September 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28944638/-unknown-title
#5
(no author information available yet)
Clinical judgment is a critical concept for the development of nursing and nursing education. Its theoretical origins are multiple and its definition is not yet consensus. The analysis of the scientific and professional literature shows heterogeneous and dispersed points of views, notably on the role of intuition, on its cognitive and metacognitive dimensions, and on its proximity to other concepts. Between professional stakes and epistemological constructions, clinical judgment is still an emerging concept...
August 17, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28944632/-student-pursuing-a-bachelor-of-science-in-nursing-160-between-process-of-professionalization-and-professional-development-in-swiss-and-belgien
#6
Myriam Graber, Veronique Haberey-Knuessi
The predictable shortage of nursing staff, in Switzerland as in the rest of Europe, continues to highlight a recurring problem for public health policy. The issue here is not just questions about the care and treatment of patients or the quality of such care, but also about the conditions necessary for adequate staff recruitment and the long-term professional engagement of health care personnel. Training in nursing care at the Universities of Applied Science of Western Switzerland is also indirectly concerned by rationalisation measures currently in force in the public Activé par Editorial Manager® et Preprint Manager® appartenant à Aries Systems Corporation health sector...
April 19, 2017: Recherche en Soins Infirmiers
https://www.readbyqxmd.com/read/28944496/the-unidirectional-hypoxia-activated-prodrug-oct1002-inhibits-growth-and-vascular-development-in-castrate-resistant-prostate-tumors
#7
Heather Nesbitt, Jenny Worthington, Rachel J Errington, Laurence H Patterson, Paul J Smith, Stephanie R McKeown, Declan J McKenna
BACKGROUND: OCT1002 is a unidirectional hypoxia-activated prodrug (uHAP) OCT1002 that can target hypoxic tumor cells. Hypoxia is a common feature in prostate tumors and is known to drive disease progression and metastasis. It is, therefore, a rational therapeutic strategy to directly target hypoxic tumor cells in an attempt to improve treatment for this disease. Here we tested OCT1002 alone and in combination with standard-of-care agents in hypoxic models of castrate-resistant prostate cancer (CRPC)...
September 24, 2017: Prostate
https://www.readbyqxmd.com/read/28944426/experimental-evaluation-of-the-efficiency-of-lipid-module-enriched-with-docosahexaenoic-acid-and-astaxantin
#8
Yu S Sidorova, V А Sarkisyan, N A Petrov, A A Kochetkova, V K Mazo
Rats of the experimental group for 30 days received a ration in which the fat component (sunflower oil) was completely substituted with a lipid module enriched with docosahexaenoic acid and astaxanthin. Anxiety of animals in elevated plus-maze test and muscle tone in the grip strength test were evaluated before and after the experiment. Exhausting treadmill exercise was simulated after 30 days of feeding the lipid module. Modification of the lipid component of the diet (enrichment with docosahexaenoic acid and astaxanthin) reduced fatigue during exhausting physical exercise, increased muscle tone, and produced an anxiolytic effect...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28944416/regulating-the-alky-chain-length-of-fatty-acid-didanosine-prodrugs-and-evaluating-its-role-in-albumin-binding
#9
Hongxiang Chen, Gang Wang, Lanzhen Sun, Huicong Zhang, Mengchi Sun, Jin Sun, Lei Shang, Cong Luo
Rational design of prodrugs for efficient albumin binding shows distinct advantages in drug delivery in terms of drug availability, systemic circulation, and potential targeting effect. And fatty acids are good candidates due to their high affinity to albumin. However, how the alkyl chain length of fatty acids affects the binding dynamics between prodrugs and albumin, despite its importance, is still unclear. In the present study, three prodrugs of didanosine (DDI) and fatty acids were designed and synthesized to evaluate the effect of the alkyl chain length on prodrug-albumin binding process, including capric acid-didanosine (CA-DDI), myristic acid-didanosine (MA-DDI), and stearic acid-didanosine (SA-DDI)...
September 24, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28944229/targeting-trisomic-treatments-optimizing-dyrk1a-inhibition-to-improve-down-syndrome-deficits
#10
REVIEW
Megan Stringer, Charles R Goodlett, Randall J Roper
Overexpression of Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A), located on human chromosome 21, may alter molecular processes linked to developmental deficits in Down syndrome (DS). Trisomic DYRK1A is a rational therapeutic target, and although reductions in Dyrk1a genetic dosage have shown improvements in trisomic mouse models, attempts to reduce Dyrk1a activity by pharmacological mechanisms and correct these DS-associated phenotypes have been largely unsuccessful. Epigallocatechin-3-gallate (EGCG) inhibits DYRK1A activity in vitro and this action has been postulated to account for improvement of some DS-associated phenotypes that have been reported in preclinical studies and clinical trials...
September 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28944163/weathering-the-storm-improving-therapeutic-interventions-for-cytokine-storm-syndromes-by-targeting-disease-pathogenesis
#11
Lehn K Weaver, Edward M Behrens
Cytokine storm syndromes require rapid diagnosis and treatment to limit the morbidity and mortality caused by the hyperinflammatory state that characterizes these devastating conditions. Herein, we discuss the current knowledge that guides our therapeutic decision-making and personalization of treatment for patients with cytokine storm syndromes. Firstly, ICU-level supportive care is often required to stabilize patients with fulminant disease while additional diagnostic evaluations proceed to determine the underlying cause of cytokine storm...
March 2017: Current Treatment Options in Rheumatology
https://www.readbyqxmd.com/read/28944159/the-future-of-periodontal-systemic-associations-raising-the-standards
#12
REVIEW
P Mark Bartold, Angelo Mariotti
PURPOSE OF REVIEW: Periodontal medicine recognizes a "bidirectional" interaction between periodontitis and systemic conditions. Unfortunately, the facile ability to publish a periodontal-systemic association, regardless of biologic plausibility or rigorous scientific scrutiny, continues without abate. RECENT FINDINGS: The increasing number of periodontal-systemic associations corrupts the ability of dentists to distinguish which of the associations are spurious and which are valid...
2017: Current Oral Health Reports
https://www.readbyqxmd.com/read/28943981/assessment-of-health-seeking-behaviour-and-self-medication-among-general-public-in-the-state-of-penang-malaysia
#13
Omar T Dawood, Mohamed A Hassali, Fahad Saleem, Inas R Ibrahim, Aseel H Abdulameer, Hanan H Jasim
BACKGROUND: Patients' behaviour in making decisions regarding health is currently changing from passive recipients to recipients who play an active role in taking action to control their health and taking self-care initiatives. OBJECTIVES: This study was conducted to evaluate the health seeking behaviour among general public and its associated factors; and to evaluate the medicine taking behaviour in public and the practice of self-medication. METHODS: A cross-sectional study was undertaken among general public in Penang Island, Malaysia...
July 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28943868/microbial-shifts-in-the-intestinal-microbiota-of-salmonella-infected-chickens-in-response-to-enrofloxacin
#14
Jun Li, Haihong Hao, Guyue Cheng, Chunbei Liu, Saeed Ahmed, Muhammad A B Shabbir, Hafiz I Hussain, Menghong Dai, Zonghui Yuan
Fluoroquinolones (FQs) are important antibiotics used for treatment of Salmonella infection in poultry in many countries. However, oral administration of fluoroquinolones may affect the composition and abundance of a number of bacterial taxa in the chicken intestine. Using 16S rRNA gene sequencing, the microbial shifts in the gut of Salmonella infected chickens in response to enrofloxacin treatments at different dosages (0, 0.1, 4, and 100 mg/kg b.w.) were quantitatively evaluated. The results showed that the shedding levels of Salmonella were significantly reduced in the high dosage group as demonstrated by both the culturing method and 16S rRNA sequencing method...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28943763/effects-of-different-feeding-regimes-on-deer-meat-venison-quality-following-chilled-storage-condition
#15
Kwan Woo Kim, Hyung Soo Park, Sung Soo Lee, Seong Heum Yeon, Chang Yeon Cho, Sang Woo Kim, Jinwook Lee
This study was conducted to investigate the effect of different feeding regimes on the quality of deer meat (venison) following storage at 4°C for various durations. Twelve 5-year-old elk stags about 350 kg were stratified by weight and randomly assigned to one of four dietary treatments (three elk stags per treatment). The dietary treatments consisted of a feeding concentrate of 1.5% of body weight (T1), feeding concentrate of 1.8% of body weight (T2), feeding concentrate ad libitum (T3), or a home-mixed ration ad libitum (T4)...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28943346/investigating-a-probable-relationship-between-microplastics-and-potentially-toxic-elements-in-fish-muscles-from-northeast-of-persian-gulf
#16
Razegheh Akhbarizadeh, Farid Moore, Behnam Keshavarzi
Although weekly consumption of fish is recommended, the presence of contaminants in seafood has raised many concerns regarding the benefits of fish intake. In the present study microplastics (MPs) and metals' concentration in muscles of both benthic and pelagic fish species from northeast of Persian Gulf were investigated and the risk/benefit of their consumption was assessed. The results demonstrated that MPs and Hg in all species and Se in benthic species increase with size, while relationship between other metals, and fish size is not consistent...
September 21, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28943324/the-society-for-immunotherapy-of-cancer-biomarkers-task-force-recommendations-review
#17
REVIEW
Lisa H Butterfield
The clinical successes in cancer immunotherapy have led to a critical need for biomarkers in cancer immunotherapy. It is of the utmost importance to know who is most likely to benefit from these therapies (predictive biomarkers) but also who is starting to respond (prognostic biomarkers) and how the therapy functions in order to make rational combination choices (mechanism of action biomarkers). The Society for Immunotherapy of Cancer (SITC) Biomarkers Task Force addressed the state of the art and made a series of recommendations for the field, which is summarized here...
September 21, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28943239/how-to-effectively-treat-acute-leukemia-patients-bearing-mll-rearrangements
#18
REVIEW
Dieter Steinhilber, Rolf Marschalek
Chromosomal translocations - leading to the expression of fusion genes - are well-studied genetic abberrations associated with the development of leukemias. Most of them represent altered transcription factors that affect transcription or epigenetics, while others - like BCR-ABL - are enhancing signaling. BCR-ABL has become the prototype for rational drug design, and drugs like Imatinib and subsequently improved drugs have a great impact on cancer treatments. By contrast, MLL-translocations in acute leukemia patients are hard to treat, display a high relapse rate and the overall survival rate is still very poor...
September 21, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28942647/pore-breathing-of-metal-organic-frameworks-by-environmental-transmission-electron-microscopy
#19
Lucas R Parent, Huy Pham, Joseph P Patterson, Michael S Denny, Seth M Cohen, Nathan C Gianneschi, Francesco Paesani
Metal-organic frameworks (MOFs) have emerged as an effective platform for the rational design of multifunctional materials, combining large specific surface areas with flexible, periodic frameworks that can undergo reversible structural transitions, or "breathing", upon temperature and pressure changes, and through gas adsorption/desorption processes. Although MOF breathing can be inferred from the analysis of adsorption isotherms, direct observation of the structural transitions has been lacking, and the underlying processes of framework-reorganization in individual MOF nanocrystals is largely unknown...
September 23, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28942113/novel-serms-based-on-3-aryl-4-aryloxy-2h-chromen-2-one-skeleton-a-possible-way-to-dual-er%C3%AE-vegfr-2-ligands-for-treatment-of-breast-cancer
#20
Guoshun Luo, Xinyu Li, Guoqing Zhang, Chengzhe Wu, Zhengpu Tang, Linyi Liu, Qidong You, Hua Xiang
There is considerable interest in developing new SERMs as multifunctional agents in women's health. Development of dual selective estrogen receptor modulators/VEGFR-2 inhibitors (SERMs/V-2I) has been an attractive strategy for the discovery of new breast cancer therapeutic agents. Our previous efforts led to the preparation of a series of 3-aryl-4-anilino-2H-chromen-2-ones endowed with potent estrogen receptor binding affinity and anti-proliferative efficacy. In this study, various structurally related 3-aryl-4-anilino/aryloxy-2H-chromen-2-one analogues were rationally designed, synthesized and evaluated as a new chemo-type of dual ERα and VEGFR-2 inhibitors...
September 14, 2017: European Journal of Medicinal Chemistry
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