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Songyuan Tao, Siyu Lu, Yijia Geng, Shoujun Zhu, Simon Redfern, Yubin Song, Tanglue Feng, Weiqing Xu, Bai Yang
Polymer carbon dots (PCDs) are proposed as a new class of room temperature phosphorescence (RTP) materials. The abundant energy levels in PCDs increase the probability of intersystem crossing (ISC) and their covalently-crosslinked framework structures greatly suppress the non-radiative transitions. The efficient methods allow the manufacture of PCDs with unique RTP properties in air without the need for additional metal complexing or for the adopting of complicated matrix compositing. They thus provide a route towards the rational design of metal-free RTP materials that may be synthesized easily...
January 22, 2018: Angewandte Chemie
Takumi Yamamoto, Mitsunaga Narushima, Isao Koshima
BACKGROUND: Lymphaticovenular anastomosis (LVA) has become one of the useful surgical treatments for compression-refractory lower extremity lymphedema (LEL). It is important to anastomose larger lymphatic vessels with abundant lymph flows in LVA surgery. This study aimed to clarify factors associated with lymphatic vessel diameter. METHODS: One hundred thirty-four LEL patients who underwent pre-operative indocyanine green (ICG) lymphography and LVA from June 2009 to August 2014 in a single institution were included in this retrospective observational study...
January 22, 2018: Journal of Surgical Oncology
Yunke Zhu, Xiaolong Zhang, Yang Hu, Lunxu Liu
Minimally invasive esophagectomy has several benefits as an effective alternative treatment for esophageal cancer. The three-phase esophageal resection may be the most popular approach to esophagectomy. Numerous thoracoport designs are available for the thoracoscopic procedure. The present study aims to contribute a distinctive three-port technique that is designed to minimize surgical trauma and facilitate operation during the thoracoscopic procedure. In this paper, we describe and demonstrate the details of the port design and each operation step...
January 22, 2018: Journal of Surgical Oncology
Daniel G Congrave, Yu-Ting Hsu, Andrei S Batsanov, Andrew Beeby, Martin R Bryce
The potential of intramolecular π-π interactions to influence the photophysical properties of diiridium complexes is an unexplored topic, and provides the motivation for the present study. A series of diarylhydrazide-bridged diiridium complexes functionalised with phenylpyridine (ppy)-based cyclometalating ligands is reported. It is shown by NMR studies in solution and single crystal X-ray analysis that intramolecular π-π interactions between the bridging and cyclometalating ligands rigidify the complexes leading to high luminescence quantum efficiencies in solution and in doped films...
January 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Masahiro Sonoshita, Alex P Scopton, Peter M U Ung, Matthew A Murray, Lisa Silber, Andres Y Maldonado, Alexander Real, Avner Schlessinger, Ross L Cagan, Arvin C Dar
Synthetic tailoring of approved drugs for new indications is often difficult, as the most appropriate targets may not be readily apparent, and therefore few roadmaps exist to guide chemistry. Here, we report a multidisciplinary approach for accessing novel target and chemical space starting from an FDA-approved kinase inhibitor. By combining chemical and genetic modifier screening with computational modeling, we identify distinct kinases that strongly enhance ('pro-targets') or limit ('anti-targets') whole-animal activity of the clinical kinase inhibitor sorafenib in a Drosophila medullary thyroid carcinoma (MTC) model...
January 22, 2018: Nature Chemical Biology
Changxuan Shao, Haotian Tian, Tianyu Wang, Zhihua Wang, Shuli Chou, Anshan Shan, Baojing Cheng
Although membrane lytic antimicrobial peptides (AMPs) show enormous potential for addressing mounting global antibiotic resistance, therapeutic applications are hindered by their weak antimicrobial activity, high toxicity, salt sensitivity and poor understanding of structure-activity relationships. To investigate the effects of different parameters on the biological activities of AMPs, a rational approach was adopted to design a series of short cationic α-helical peptides comprising the Ac-WxKyWxzzyKxWyK-NH2 sequence, where x: cationic residues (Arg or Lys), y: hydrophobic residues (Ala, Val, Ile or Leu), and zz: β-turn (rigid D-Pro-Gly turn or flexible Gly-Gly turn)...
January 16, 2018: Acta Biomaterialia
M Alkilzy, R M Santamaria, J Schmoeckel, C H Splieth
Modern approaches in caries treatment involve lesion management without tissue removal. Regenerative medicine focuses on replacing damaged tissues with biologically similar tissues. This article discusses the scientific evidence and clinical results for self-assembling peptides in modern caries management. The biomimetic remineralization promoted by self-assembling peptide P11-4 has been proven in vitro as an effective therapy for initial caries. P11-4 was rationally designed to promote formation of hydroxyapatite on its surface...
February 2018: Advances in Dental Research
R A Burne
Technological advances in DNA sequencing have provided unprecedented insights into the composition of the oral microbiome in health and disease, and RNA-sequencing and metabolomics-related technologies are beginning to yield information on the activities of these organisms. Importantly, progress in this area has brought the scientific community closer to an understanding of what constitutes a health-associated microbiome and is supporting the notion that the microbiota in healthy sites assumes an active role in promoting health and suppressing the acquisition, persistence, and activities of overt and opportunistic pathogens...
February 2018: Advances in Dental Research
Masaaki Abe, Hiroto Mukotaka, Taro Fujioka, Toru Okawara, Kei Umegaki, Toshikazu Ono, Yoshio Hisaeda
A phosphorus(v) complex of porphycene [P(OEPc)(OMe)2]PF6 (OEPc = 2,3,6,7,12,13,16,17-octaethylporphycenato dianion) has been synthesized and structurally characterized as the first porphycene derivative incorporating nonmetal elements in the macrocyclic cavity. An extremely low energy level of the LUMO is observed, which is rationalized by the low-lying π* orbital of the porphycene ring coupled with the insertion of the highly-inductive pentavalent phosphorus centre. The compound is luminescent in bright red with a quantum yield of 22...
January 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Zhenggang Zhu
The 12th International Gastric Cancer Congress (12th IGCC ) was successfully held in Beijing, China on 20th-23rd April, 2017, which gave Chinese surgeons a great opportunity to share clinical progress and experience in the surgical treatment of gastric cancer with colleagues from different countries. At the end of 2017, this article hereby reviews briefly the achievements of surgical work of gastric cancer, which was done by our Chinese surgeons in this year. Some aspects will be reviewed, aiming at summarizing experience, affirming achievement, finding out the gap and promoting improvement in the future...
January 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Andreas F Mavrogenis, Konstantinos Markatos, Vasilios Nikolaou, Ariadne Gartziou-Tatti, Panayotis N Soucacos
Congenital anomalies of the limbs have been observed since ancient human civilizations, capturing the imagination of ancient physicians and people. The knowledge of the era could not possibly theorize on the biologic aspects of these anomalies; however, from the very beginning of civilization the spiritual status of people attempted to find a logical explanation for the existence of such cases. The next logical step of the spiritual and religious system of the ancients was to correlate these anomalies with the Gods and to attribute them to a different level of existence in order to rationalize their existence...
January 21, 2018: International Orthopaedics
Cristian Celis-Barros, Dayán Páez-Hernández, María J Beltrán-Leiva, Ramiro Arratia-Perez
Research on heavy actinides has experienced an increased interest in the last few years due to new synthetic techniques and recent technological advances that have allowed for obtaining important information even from very small samples. This area presents challenges not only from the experimental point of view but also from the theoretical perspective. This work deals with a multiconfigurational CASSCF and NEVPT2 benchmark study based on a two-step methodology that considers first correlation effects and then the spin-orbit coupling applied to berkelium (Bk), californium (Cf), einsteinium (Es) and fermium (Fm) hexahalides...
January 22, 2018: Physical Chemistry Chemical Physics: PCCP
Libo Gao, Hongti Zhang, James Utama Surjadi, Peifeng Li, Ying Han, Dong Sun, Yang Lu
Recently, solid asymmetric supercapacitor (ASC) has been deemed as an emerging portable power storage or backup device for harvesting natural resources. Here we rationally engineered a hierarchical, mechanically stable heterostructured FeCo@NiCo layered double hydroxide (LDH) with superior capacitive performance by a simple two-step electrodeposition route for energy storage and conversion. In situ scanning electron microscope (SEM) nanoindentation and electrochemical tests demonstrated the mechanical robustness and good conductivity of FeCo-LDH...
January 22, 2018: Nanoscale
Matthieu Jules
Synthetic Biology (SB) aims at the rational design and engineering of novel biological functions and systems. By facilitating the engineering of living organisms, SB promises to facilitate the development of many new applications for health, biomanufacturing, and the environment. Over the last decade, SB promoted the construction of libraries of components enabling the fine-tuning of genetic circuits expression and the development of novel genome engineering methodologies for many organisms of interest. SB thus opened new perspectives in the field of metabolic engineering, which was until then mainly limited to (over)producing naturally synthesized metabolic compounds...
December 11, 2017: Microbial Cell
Marijana Đaković, Željka Soldin, Boris-Marko Kukovec, Ivan Kodrin, Christer B Aakeröy, Nea Baus, Tamara Rinkovec
In order to develop transferable and practical avenues for the assembly of coordination complexes into architectures with specific dimensionality, a strategy utilizing ligands capable of simultaneous metal coordination and self-complementary hydrogen bonding is presented. The three ligands used, 2(1H)-pyrazinone, 4(3H)-pyrimidinone and 4(3H)-quinazolinone, consistently deliver the required synthetic vectors in a series of CdII coordination polymers, allowing for reproducible supramolecular synthesis that is insensitive to the different steric and geometric demands from potentially disruptive counterions...
January 1, 2018: IUCrJ
Xueqin He, Lujia Han, Jinyi Ge, Guangqun Huang
This study establishes an optimal mathematical modelling to rationally describe the dynamic changes and spatial distribution of temperature and oxygen concentration in the aerobic composting process using coupling mass-heat-momentum transfer based on the microbial mechanism. Two different conditional composting experiments, namely continuous aeration and intermittent aeration, were performed to verify the proposed model. The results show that the model accurately predicted the dynamic changes in temperature (case I: R2 = 0...
January 9, 2018: Bioresource Technology
Jeffrey Winking
The nature-nurture debate is one that biologists often dismiss as a false dichotomy, as all phenotypic traits are the results of complex processes of gene and environment interactions. However, such dismissiveness belies the ongoing debate that is unmistakable throughout the biological and social sciences concerning the role of biological influences in the development of psychological and behavioral traits in humans. Many have proposed that this debate is due to ideologically driven biases in the interpretation of results...
January 2018: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
Lanteng Wang, Wen Meng Jiang, Xing Shen, Xiangmei Li, Xinan Huang, Zhenlin Xu, Yuanming Sun, Shun-Wan Chan, Lingwen Zeng, Sergei Alexandrovich Eremin, Hongtao Lei
Immunoassay methods are important to monitor β-agonists illegally used for reducing animal fat deposition in livestock. However, there is no a simultaneous screening surveillance immunoassay for possibly occurred various β-agonist chemicals in food. In this study, using an R-(-)-salbutamol derivative as the immunizing hapten, an antibody recognizing 31 β-agonists and analogues was generated for the first time. Three-dimensional quantitative structure-activity relationship (3D QSAR) revealed that strong steric and hydrophobic fields around the hapten spacer near C-2, as well as a chirality at C-1´, dominantly modulated the class specificity of the raised antibody...
January 21, 2018: Analytical Chemistry
Ana Díaz-Fernández, Rebeca Miranda-Castro, Noemí de-Los-Santos-Álvarez, María Jesús Lobo-Castañón
Advances in proteomics have fueled the search for novel cancer biomarkers with higher selectivity. Differential expression of low abundant proteins has been the usual way of finding those biomarkers. The existence of a selective receptor for each biomarker is compulsory for their use in diagnostic/prognostic assays. Antibodies are the receptors of choice in most cases although aptamers are becoming familiar because of their facile and reproducible synthesis, chemical stability as well as comparable affinity and selectivity...
January 20, 2018: Analytical and Bioanalytical Chemistry
Sergio Iannazzo, Maurizio Benucci, Ennio Giulio Favalli
OBJECTIVES: Switching to a different mechanism of action in rheumatoid arthritis (RA) patients after a first anti-TNF-α has proved to be effective. The objective of this study was a health economic assessment in Italy. METHODS: The study was conducted using a pharmacoeconomic model with a 3-year time horizon. Effectiveness was measured as days gained in low disease activity (LDA; DAS28-ESR <3.2) or in remission (DAS28-ESR <2.6). The model simulated the response to treatments, based on the Rotation Or Change (ROC) trial, the probability of discontinuation and switch to a 3rd-line biologic, and the transition to death...
January 15, 2018: Clinical and Experimental Rheumatology
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