keyword
https://read.qxmd.com/read/38547193/impact-of-covid-19-vaccination-on-liver-transplant-recipients-experience-in-a-reference-center-in-mexico
#1
JOURNAL ARTICLE
Daniel Azamar-Llamas, Josealberto Sebastiano Arenas-Martinez, Antonio Olivas-Martinez, Jose Victor Jimenez, Eric Kauffman-Ortega, Cristian J García-Carrera, Bruno Papacristofilou-Riebeling, Fabián E Rivera-López, Ignacio García-Juárez
BACKGROUND AND AIMS: COVID-19 vaccination has proved to be effective to prevent symptomatic infection and severe disease even in immunocompromised patients including liver transplant patients. We aim to assess the impact of COVID-19 vaccination on the mortality and development of severe and critical disease in our center. METHODS: A retrospective cohort study of LT patients in a reference center between March 2020 and February 2022. Demographic data, cirrhosis etiology, time on liver transplantation, immunosuppressive therapies, and vaccination status were recorded at the time of diagnosis...
2024: PloS One
https://read.qxmd.com/read/38547004/bk-polyomavirus-associated-nephropathy-graft-inflammation-and-immunosuppression-shedding-light-on-the-conundrum
#2
EDITORIAL
Mario Fernández-Ruiz
No abstract text is available yet for this article.
March 28, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/38547002/effect-of-steroid-pulses-in-severe-bk-virus-allograft-nephropathy-with-extensive-interstitial-inflammation
#3
JOURNAL ARTICLE
Julien Carrillo, Arnaud Del Bello, Federico Sallusto, Audrey Delas, Magali Colombat, Jean Michel Mansuy, Jacques Izopet, Nassim Kamar, Julie Belliere
INTRODUCTION: As there is no specific antiviral treatment currently available for BK polyomavirus associated nephropathy (BKVAN), its management relies on immunosuppression reduction in kidney transplant patients. Data on efficacy of steroid pulses in this indication are lacking. METHODS: We performed a retrospective monocenter study on 64 patients diagnosed with biopsy-proven BKVAN. Patients within the "pulse group" (n = 37) received IV methylprednisolone 10 mg/kg 3 days consecutively...
March 28, 2024: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/38546908/resveratrol-ameliorates-glioblastoma-inflammatory-response-by-reducing-nlrp3-inflammasome-activation-through-inhibition-of-the-jak2-stat3-pathway
#4
JOURNAL ARTICLE
Chao Zhang, Qian Peng, Yuhang Tang, Chengcheng Wang, Shuai Wang, Dong Yu, Shiqiang Hou, Yu Wang, Lanlan Zhang, Ning Lin
OBJECTIVES: The aim of this study was to investigate the anti-tumor effect of resveratrol (RSV) on glioblastoma (GBM) and its specific mechanism in improving the inflammatory response of the tumor microenvironment. The tumor microenvironment of GBM is highly neuroinflammatory, inducing tumor immunosuppression. Therefore, ameliorating the inflammatory response is an important focus for anti-tumor research. METHODS: The anti-tumor effect of RSV on GBM was demonstrated through in vitro cellular assays, including CCK-8, EdU, PI staining, Transwell, wound healing assay, and flow cytometry...
March 28, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38546704/a-review-on-traditional-uses-phytochemistry-pharmacology-and-clinical-application-of-tinospora-sinensis-lour-merr
#5
JOURNAL ARTICLE
Yan Liang, Shao-Bo Guo, Chang Xu, Ying-Ying Su, Cheng-Yuan Su, Wei Zhang, Bin Liu
Tinospora sinensis (T. sinensis), whose Tibetan name is "Lezhe", as a traditional medicine, is widely distributed in China, India and Sri Lanka. It is used for the treatment of rheumatic arthralgia, sciatica, lumbar muscle strain and bruises. Research over the previous decades indicated that T. sinensis mainly contains terpenes, lignans, alkaloids, phenol glycosides and other chemical components. A wide range of pharmacologic activities such as anti-inflammatory, analgesic, immunosuppressive, anti-aging, anti-radiation, anti-leishmania and liver protection have been reported...
March 28, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38546642/neuroinvasive-west-nile-virus-infection-in-immunosuppressed-and-immunocompetent-adults
#6
JOURNAL ARTICLE
Amir A Mbonde, David Gritsch, Ehab Y Harahsheh, Sabirah N Kasule, Shemonti Hasan, Angela M Parsons, Nan Zhang, Richard Butterfield, Harn Shiue, Kathryn A Norville, Jenna L Reynolds, Holenarasipur R Vikram, Brian Chong, Marie F Grill
IMPORTANCE: West Nile virus (WNV) is the leading cause of human arboviral disease in the US, peaking during summer. The incidence of WNV, including its neuroinvasive form (NWNV), is increasing, largely due to the expanding distribution of its vector, the Culex mosquito, and climatic changes causing heavy monsoon rains. However, the distinct characteristics and outcomes of NWNV in individuals who are immunosuppressed (IS) and individuals who are not IS remain underexplored. OBJECTIVE: To describe and compare clinical and radiographic features, treatment responses, and outcomes of NWNV infection in individuals who are IS and those who are not IS...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38546303/delayed-onset-of-symptoms-after-a-rattlesnake-bite-in-a-renal-transplant-patient-a-case-report
#7
JOURNAL ARTICLE
Thomas A Rogers, John Herrick
INTRODUCTION: The United States is home to two major families of venomous snakes, Crotalids and Elapids. The Crotalid family, also known as pit vipers, is well known for being among the most frequent causes of snakebites reported. Crotalid envenomation can present with local findings, hematologic toxicity, and systemic toxicity. Identification of envenomated patients is key to determining who needs antivenom. Most sources recommend an observation period of six to eight hours after the snakebite to determine whether the bite was "dry" or the patient was exposed to venom...
February 2024: Clinical Practice and Cases in Emergency Medicine
https://read.qxmd.com/read/38546138/live-biotherapeutic-products-for-the-prevention-of-recurrent-clostridioides-difficile-infection
#8
REVIEW
Natasha N Pettit, Kristy M Shaeer, Elias B Chahine
OBJECTIVE: To review the efficacy, safety, and role of live biotherapeutic products (LBPs) in the prevention of recurrent Clostridioides difficile infection (rCDI). DATA SOURCES: A literature search was performed using PubMed and Google Scholar (through February 2024) with search terms RBX2660, SER-109, and fecal microbiota. Other resources included abstracts presented at recent conferences, national clinical practice guidelines, and manufacturers' websites. STUDY SELECTION AND DATA EXTRACTION: All relevant studies, trial updates, conference abstracts, and guidelines in the English language were included...
March 28, 2024: Annals of Pharmacotherapy
https://read.qxmd.com/read/38545939/glutathione-responsive-and-hydrogen-sulfide-self-generating-nanocages-based-on-self-weaving-technology-to-optimize-cancer-immunotherapy
#9
JOURNAL ARTICLE
Shuangquan Gou, Wenbo Geng, Yanan Zou, Fangye Chen, Tingting He, Qiaojian Duan, Zizhen Qin, Liangsheng Li, Jiang Xia, Yongsheng Yu, Qian Feng, Kaiyong Cai
As an ideal drug carrier, it should possess high drug loading and encapsulation efficiency and precise drug targeting release. Herein, we utilized a template-guided self-weaving technology of phase-separated silk fibroin (SF) in reverse microemulsion (RME) to fabricate a kind of hyaluronic acid (HA) coated SF nanocage (HA-gNCs) for drug delivery of cancer immunotherapy. Due to the hollow structure, HA-gNCs were capable of simultaneous encapsulation of the anti-inflammatory drug betamethasone phosphate (BetP) and the immune checkpoint blockade (ICB) agent PD-L1 antibody (αPD-L1) efficiently...
March 28, 2024: ACS Nano
https://read.qxmd.com/read/38545846/trauma-plays-an-important-role-in-acral-melanoma-a-retrospective-study-of-303-patients
#10
JOURNAL ARTICLE
Rong Huang, Mengke Zhao, Guiying Zhang, Yueling Yang, Jiayu Wang, Kelin Zheng, Lin Li, Xinyu Su, Lianjun Zhao, Yirong Wu, Zhengyun Zou
INTRODUCTION: Acral melanoma (AM) is the most common subtype of malignant melanoma in China, with a very poor prognosis. Despite the frequent reporting of trauma events in AM cases, the precise etiology of AM remains elusive. METHODS: A retrospective analysis was conducted on a cohort of 303 AM patients at Nanjing Drum Tower Hospital. The patients were categorized into four distinct groups based on different patterns of disease onset: trauma type (Type 1), pigmented nevus type (Type 2), pigmented nevi with trauma (Type 3), and pigmented nevi with natural ulceration (Type 4)...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38545758/tigit-blockade-reshapes-the-tumor-microenvironment-based-on-the-single-cell-rna-sequencing-analysis
#11
JOURNAL ARTICLE
Yanyan Lang, Hao Huang, Hongwei Jiang, Shaoxian Wu, Yaping Chen, Bin Xu, Yingting Liu, Dawei Zhu, Xiao Zheng, Lujun Chen, Jingting Jiang
Immune checkpoint blockade therapy is a pivotal approach in treating malignant tumors. TIGIT has emerged as a focal point of interest among the diverse targets for tumor immunotherapy. Nonetheless, there is still a lack of comprehensive understanding regarding the immune microenvironment alterations following TIGIT blockade treatment. To bridge this knowledge gap, we performed single-cell sequencing on mice both before and after the administration of anti-TIGIT therapy. Our analysis revealed that TIGIT was predominantly expressed on T cells and natural killer (NK) cells...
March 28, 2024: Journal of Immunotherapy
https://read.qxmd.com/read/38545728/predictive-factors-of-renal-graft-failure-in-tunisian-children-and-young-adults-a-retrospective-study
#12
JOURNAL ARTICLE
Abir Boussetta, Manel Jellouli, Tahar Gargah, Meriem Hajji, Hafedh Hedri, Ezzeddine Abderrahim
INTRODUCTION: Pediatric end-stage renal disease is a rare but severe condition that causes numerous complications and impairs the quality of life of children. Kidney transplantation is the therapy of choice in pediatric end-stage renal disease. AIM: Our study aimed to identify the predictive factors of renal graft failure after kidney transplantation in Tunisian children and young adults. METHODS: We conducted a retrospective bicentric study of children and young adults (age≤20 years) who had undergone renal transplantation between 1989 and 2019 in Tunisia...
January 5, 2024: La Tunisie Médicale
https://read.qxmd.com/read/38545219/heteroleptic-s-c-cyclometallated-gold-iii-complexes-as-novel-antiviral-agents
#13
JOURNAL ARTICLE
María Balsera-Manzanero, Raquel G Soengas, Marta Carretero-Ledesma, Carlos Ratia, M José Iglesias, Jerónimo Pachón, Fernando López-Ortiz, Elisa Cordero, Sara M Soto, Javier Sánchez-Céspedes
Despite the increasingly widespread clinical impact of adenovirus (HAdV) infections in healthy individuals and the associated high morbidity in immunosuppressed patients, particularly among the paediatric population, a specific treatment for this virus has yet to be developed. In this study, we report the anti-HAdV activity of sub-micromolar concentrations of four heteroleptic (C^S)-cycloaurated complexes bearing a single thiophosphinamide [ Au(dpta)Cl 2 , Au(dpta)(mrdtc) , and Au(dpta)(dedtc) ] or thiophosphonamide [ Au(bpta)(dedtc) ] chelating ligand and a dithiocarbamate moiety...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38544737/nanomaterials-modulate-tumor-associated-macrophages-for-the-treatment-of-digestive-system-tumors
#14
REVIEW
Hao Li, Shuai Wang, Zhengqiang Yang, Xianwei Meng, Meng Niu
The treatment of digestive system tumors presents challenges, particularly in immunotherapy, owing to the advanced immune tolerance of the digestive system. Nanomaterials have emerged as a promising approach for addressing these challenges. They provide targeted drug delivery, enhanced permeability, high bioavailability, and low toxicity. Additionally, nanomaterials target immunosuppressive cells and reshape the tumor immune microenvironment (TIME). Among the various cells in the TIME, tumor-associated macrophages (TAMs) are the most abundant and play a crucial role in tumor progression...
June 2024: Bioactive Materials
https://read.qxmd.com/read/38544631/acute-cytomegalovirus-colitis-presenting-as-exacerbation-of-ulcerative-colitis-a-case-report
#15
Varun Daiya, Nishtha Manuja, Sourya Acharya, Sunil Kumar, Sharwari Jaiswal
This case report presents a 24-year-old female with a history of ulcerative colitis (UC) who sought care for symptoms initially suggestive of the disease exacerbation but was later diagnosed as acute cytomegalovirus (CMV) colitis. The patient's clinical course, marked by watery diarrhea, blood in stools, vomiting, and fever, raised suspicion of a UC flare. However, a nuanced diagnostic approach revealed CMV superinfection, including computed tomography, colonoscopy, and tissue polymerase chain reaction (PCR)...
February 2024: Curēus
https://read.qxmd.com/read/38544583/pyomyositis-after-a-group-c-streptococcal-toxic-shock-syndrome
#16
Maria Pacheco, João C Rodrigues, Hugo R Almeida, Adriano Cardoso, Ana Teresa Moreira
Pyomyositis is a bacterial infection deep within the muscles, often leading to multiple intramuscular abscesses. While historically linked with tropical regions, its incidence in temperate zones has been increasing, primarily due to factors such as immunosuppression. Typically, it manifests as a subacute infection, although when caused by Group C Streptococcus and resulting in toxic shock syndrome, it can lead to poorer outcomes. Here, we report a rare case of extensive multifocal bilateral pyomyositis in an immunocompetent young woman, preceded by toxic shock syndrome...
February 2024: Curēus
https://read.qxmd.com/read/38544563/transplant-trial-watch
#17
EDITORIAL
John M O'Callaghan, John Fallon
No abstract text is available yet for this article.
2024: Transplant International
https://read.qxmd.com/read/38544313/risk-factors-associated-with-fluconazole-resistance-in-candida-parapsilosis-candidemia-a-case-case-study
#18
JOURNAL ARTICLE
Sabri Atalay, Derya Çağlayan, Eren Arkalı, Ufuk Sönmez, Pınar Şamlıoğlu
BACKGROUND: Candida species are among the most important invasive pathogens in intensive care units (ICUs). Non-albicans species including Candida parapsilosis (C. parapsilosis) has increased in recent years. Fluconazole is the leading antifungal agent but resistance is a concern among C. parapsilosis species. OBJECTIVES: The aim of this study was to determine the factors associated with fluconazole resistance in patients with candidemia due to C. parapsilosis in ICUs...
March 2024: Mycoses
https://read.qxmd.com/read/38543930/long-term-observation-of-sars-cov-2-vaccination-response-upon-high-efficacy-treatment-in-multiple-sclerosis-a-real-world-scenario
#19
JOURNAL ARTICLE
Muriel Schraad, Stefan Runkel, Walter Hitzler, Maria Protopapa, Stefan Bittner, Timo Uphaus, Frauke Zipp
Immunomodulatory and immunosuppressive therapy is needed in people with a chronic neuroinflammatory disease of the central nervous system such as multiple sclerosis (MS). Therefore, MS requires monitoring for and preventing against infectious diseases like SARS-CoV-2. Vaccination and anti-viral treatments are, in particular, recommended for elderly people and people at risk of a severe course of infection and of MS. Here, we asked whether repetitive infection or vaccination influenced responses upon receiving high efficacy treatments, namely sphingosine-1-phosphate receptor modulator (S1P) or anti-CD20 B cell antibody (anti-CD20) treatments...
March 12, 2024: Vaccines
https://read.qxmd.com/read/38543898/antibody-response-after-3-dose-booster-against-sars-cov-2-mrna-vaccine-in-kidney-transplant-recipients
#20
JOURNAL ARTICLE
Domenico Tripodi, Roberto Dominici, Davide Sacco, Gennaro Santorelli, Rodolfo Rivera, Sandro Acquaviva, Marino Marchisio, Paolo Brambilla, Graziana Battini, Valerio Leoni
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with a high rate of mortality in kidney transplant recipients (KTRs). Current vaccine strategies for KTRs seem to be unable to provide effective protection against coronavirus disease 2019 (COVID-19), and the occurrence of severe disease in some vaccinated KTRs suggested a lack of immunity. We initially analyzed the antibody response in a group of 32 kidney transplant recipients (KTRs) followed at the nephrology and dialysis unit of the Hospital Pio XI of Desio, ASST-Brianza, Italy...
March 1, 2024: Vaccines
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