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https://www.readbyqxmd.com/read/29140876/evidence-based-guidance-to-assist-volunteers-working-with-at-risk-children-in-a-school-context
#1
Emmy De Buck, Philippe Vandekerckhove, Karin Hannes
AIM: One of the activities of the Belgian Red Cross is the 'Bridging the Gap' project, in collaboration with local schools. In this project, volunteers join the teaching staff to improve personal development goals in at-risk children with poor performance. The aim of this study was to develop evidence-based guidance for the volunteers to help them choose the right didactical approach for supporting these children. METHOD: Systematic literature searches were performed in three bibliographic databases (the Campbell Library, MEDLINE and ERIC) to find the effectiveness of 16 different didactical activities...
November 14, 2017: International Journal of Evidence-based Healthcare
https://www.readbyqxmd.com/read/29139306/equilibria-kinetics-and-mechanism-for-the-degradation-of-the-cytotoxic-compound-l-n-g-nitroarginine
#2
Pham Van Quyet, Bernice Mei Jin Tan, Celine Valeria Liew, Lai Wah Chan, Quan Sing Ng, Paul Wan Sia Heng
L-N(G)-nitroarginine (LNNA), an analogue of L-arginine, is a competitive inhibitor of nitric oxide synthase which causes the selective reduction of blood flow to tumor cells. Despite the potential of LNNA to function as an adjuvant in cancer therapies, its poor solubility and stability have hindered the development of an injectable formulation of LNNA that is suitable for human administration. This work, for the first time, details a systematic study on the determination of equilibrium Ka constants and the rate law of LNNA degradation...
November 15, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29138846/itr%C3%A2-284-modulates-cell-differentiation-in-human-chronic-myelogenous-leukemia-k562-cells
#3
Jai-Sing Yang, Chao-Ying Lee, Hsin-Chung Cho, Chi-Cheng Lu, Sheng-Chu Kuo, Yen-Fang Wen, Fuu-Jen Tsai, Miau-Rong Lee, Shih-Chang Tsai
ITR‑284 is a carboxamide analog that can inhibit proliferation in human promyelocytic leukemia HL-60 cells. To understand the effects and molecular mechanisms of ITR‑284 in human erythromyeloblastoid leukemia, we treated K562 cells with different concentrations of ITR‑284 (0, 2, 4, 6, 8 and 10 nM) and all-trans retinoic acid (ATRA) (0, 0.1, 0.5, 1, 5 and 10 µM) for 24 h. The IC50 of ITR‑284 was ~10 nM in K562 cells treated for 24 h as determined by MTT assay. May-Grünwald-Giemsa staining and nitro blue tetrazolium (NBT) assays were used to determine cell morphology changes and differentiation after ITR‑284 and ATRA treatment...
November 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29138806/effect-of-bis-hydroxymethyl-alkanoate-curcuminoid-derivative-mth-3-on-cell-cycle-arrest-apoptotic-and-autophagic-pathway-in-triple-negative-breast-adenocarcinoma-mda-mb-231-cells-an-in-vitro-study
#4
Ling-Chu Chang, Min-Tsang Hsieh, Jai-Sing Yang, Chi-Cheng Lu, Fuu-Jen Tsai, Je-Wei Tsao, Yu-Jen Chiu, Sheng-Chu Kuo, Kuo-Hsiung Lee
Curcumin has been shown to exert potential antitumor activity in vitro and in vivo involved in multiple signaling pathways. However, the application of curcumin is still limited because of its poor hydrophilicity and low bio-availability. In the present study, we investigated the therapeutic effects of a novel and water soluble bis(hydroxymethyl) alkanoate curcuminoid derivative, MTH-3, on human breast adenocarcinoma MDA-MB-231 cells. This study investigated the effect of MTH-3 on cell viability, cell cycle and induction of autophagy and apoptosis in MDA-MB-231 cells...
November 14, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29137545/exploring-the-perceived-health-benefits-of-singing-in-a-choir-an-international-cross-sectional-mixed-methods-study
#5
Hilary Moss, Julie Lynch, Jessica O'Donoghue
AIM: This mixed-methods exploratory study investigates the perceived health benefits of singing in a choir from an international sample of choristers. METHOD: An online questionnaire including demographic information, 28 quantitative statements and two qualitative questions relating to the perceived health benefits of singing in a choir was distributed via email and social media over a period of 4 months to a sample of 1,779 choristers. Basic descriptives and comparisons between subgroups of the sample are presented along with thematic analysis of qualitative comments...
November 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/29136777/anti-hypertensive-and-vasodilatory-effects-of-amended-banxia-baizhu-tianma-tang
#6
Chu Shan Tan, Yean Chun Loh, Chiew Hoong Ng, Yung Sing Ch'ng, Mohd Zaini Asmawi, Mariam Ahmad, Mun Fei Yam
Although Banxia Baizhu Tianma Tang (BBT) has been long administered for hypertensive treatment in Traditional Chinese Medicine (TCM), the ratio of the herbal components that makes up the formulation has not been optimized with respect to the anti-hypertensive effect that it inherently possesses. A newly amended BBT (ABBT) formulation was developed using the evidence-based approach of orthogonal stimulus-response compatibility model. The ABBT showed enhanced therapeutic effect while maintaining its traditional theoretical approach rooted in TCM...
November 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29135040/the-suppressive-effects-of-geniposide-and-genipin-on-helicobacter-pylori-infections-in-vitro-and-in-vivo
#7
Chiung-Hung Chang, Jin-Bin Wu, Jai-Sing Yang, Yen-Ju Lai, Chiu-Hsian Su, Chi-Cheng Lu, Yuan-Man Hsu
Geniposide and genipin have been found in Gardenia jasminoides Ellis, a traditional Chinese medicine that exhibits multiple biological functions. However, no report showing the effects of geniposide and genipin on gastric protection in Helicobacter pylori infections in vitro and in vivo has been done. In this study, we clarified how geniposide and genipin suppress H. pylori-mediated inflammation in gastric AGS cells and C57BL/6 mice. Our results demonstrated that genipin shows a strong ability to inhibit H...
November 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29130840/what-works-for-wellbeing-a-systematic-review-of-wellbeing-outcomes-for-music-and-singing-in-adults
#8
Norma Daykin, Louise Mansfield, Catherine Meads, Guy Julier, Alan Tomlinson, Annette Payne, Lily Grigsby Duffy, Jack Lane, Giorgia D'Innocenzo, Adele Burnett, Tess Kay, Paul Dolan, Stefano Testoni, Christina Victor
AIMS: The role of arts and music in supporting subjective wellbeing (SWB) is increasingly recognised. Robust evidence is needed to support policy and practice. This article reports on the first of four reviews of Culture, Sport and Wellbeing (CSW) commissioned by the Economic and Social Research Council (ESRC)-funded What Works Centre for Wellbeing ( https://whatworkswellbeing.org/ ). OBJECTIVE: To identify SWB outcomes for music and singing in adults. METHODS: Comprehensive literature searches were conducted in PsychInfo, Medline, ERIC, Arts and Humanities, Social Science and Science Citation Indexes, Scopus, PILOTS and CINAHL databases...
November 1, 2017: Perspectives in Public Health
https://www.readbyqxmd.com/read/29129063/pd-catalyzed-dearomative-3-2-cycloaddition-of-3-nitroindoles-with-2-vinylcyclopropane-1-1-dicarboxylates
#9
Yi Sing Gee, Daniel J Rivinoja, Steven Mark Wales, Michael G Gardiner, John H Ryan, Christopher J T Hyland
A trans-diastereoselective Pd-catalyzed dearomative [3 + 2] cycloaddition between vinylcyclopropane dicarboxylates and 3-nitroindoles has been developed. The reaction provides densely functionalised cyclopenta[b]indolines with versatile vinyl and nitro-groups. The addition of a halide additive was found to be critical for the diastereoselectivity of the reaction, which is proposed to be a result of a rapid π-σ-π interconversion between the intermediates allowing for Curtin-Hammett control. A switch in diastereoselectivity to afford products with the vinyl and nitro groups cis to each other is observed with a 4-substituted 3-nitroindole...
November 12, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29128898/21-gene-recurrence-score-for-prognosis-and-prediction-of-taxane-benefit-after-adjuvant-chemotherapy-plus-endocrine-therapy-results-from-nsabp-b-28-nrg-oncology
#10
Eleftherios P Mamounas, Gong Tang, Soonmyung Paik, Frederick L Baehner, Qing Liu, Jong-Hyeon Jeong, S Rim Kim, Steven M Butler, Farid Jamshidian, Diana B Cherbavaz, Amy P Sing, Steven Shak, Thomas B Julian, Barry C Lembersky, D Lawrence Wickerham, Joseph P Costantino, Norman Wolmark
BACKGROUND: The 21-gene recurrence score (RS) predicts outcome and benefit from adjuvant chemotherapy benefit in breast cancer patients treated with adjuvant endocrine therapy. In the NSABP B-28 study, we evaluated the 21-gene RS for its prognostic impact and its ability to predict benefit from paclitaxel (P) in node-positive, estrogen receptor-positive (ER+) breast cancer patients treated with adjuvant chemotherapy plus tamoxifen. METHODS: The B-28 trial compared doxorubicin/cyclophosphamide (AC) with AC followed by P in 3060 patients...
November 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29128889/the-role-of-neuron-glia-interactions-in-the-emergence-of-ultra-slow-oscillations
#11
Siow-Cheng Chan, Siew-Ying Mok, Danny Wee-Kiat Ng, Sing-Yau Goh
Ultra-slow cortical oscillatory activity of 1-100 mHz has been recorded in human by electroencephalography and in dissociated cultures of cortical rat neurons, but the underlying mechanisms remain to be elucidated. This study presents a computational model of ultra-slow oscillatory activity based on the interaction between neurons and astrocytes. We predict that the frequency of these oscillations closely depends on activation of astrocytes in the network, which is reflected by oscillations of their intracellular calcium concentrations with periods between tens of seconds and minutes...
November 11, 2017: Biological Cybernetics
https://www.readbyqxmd.com/read/29127540/evaluation-of-lighting-systems-carbon-sources-and-bacteria-cultures-on-photofermentative-hydrogen-production
#12
Chengcheng Hu, Sing-Ying Choy, Apostolos Giannis
Fluorescent and incandescent lighting systems were applied for batch photofermentative hydrogen production by four purple non-sulfur photosynthetic bacteria (PNSB). The hydrogen production efficiency of Rhodopseudomonas palustris, Rhodobacter sphaeroides, Rhodobacter capsulatus, and Rhodospirillum rubrum was evaluated using different carbon sources (acetate, butyrate, lactate, and malate). Incandescent light was found to be more effective for bacteria cell growth and hydrogen production. It was observed that PNSB followed substrate selection criteria for hydrogen production...
November 10, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29123875/indications-of-early-intubation-for-patients-with-inhalation-injury
#13
Shinya Onishi, Akinori Osuka, Yuichi Kuroki, Masashi Ueyama
Aim: For patients with inhalation injury, the indications for early intubation are diverse. The purpose of this study was to identify the most reliable symptoms, physical findings, and medical examinations with which to determine the indications for early intubation in patients with inhalation injury. Methods: We retrospectively collected patient data from medical records. Collected data included age, sex, burn size, symptoms, physical findings, carboxyhemoglobin levels (COHb), and bronchial wall thickness (BWT) determined from chest computed tomography images...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29122800/studying-impact-of-nutrition-on-growth-sing-a-prospective-cohort-for-comparing-the-health-outcomes-of-young-children-with-the-dietary-quality-score
#14
Albert Lee, Calvin Ka-Man Cheung, Kenneth Lo, Vera Mei-Wan Keung, Lancelot Wai-Ho Mui, Wilson W S Tam
INTRODUCTION: This study aims to explore the prospective association between the dietary quality (DQ) of preschoolers and their health status in Hong Kong, with the body mass index as the main outcome variable. METHODS AND ANALYSIS: This prospective cohort study has recruited 3539 children aged between 2 and 4 years old, with a follow-up period of 4 years. Their diet was reported by their parents by a 3-day food diary, and their body weight and height were measured yearly with standardised instruments...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29122641/regularities-in-zebra-finch-song-beyond-the-repeated-motif
#15
Julia Hyland Bruno, Ofer Tchernichovski
The proliferation of birdsong research into the neural mechanisms of vocal learning is indebted to the remarkable stereotypy of the zebra finch's song motif. Motifs are composed of several copied syllables, which birds learn to produce in a fixed order. But at a higher level of organization-the bout-zebra finch song is no longer stereotyped. Song bouts include several repetitions of the motif, which are often linked by a variable number of short "connector" vocalizations. In this conceptual methods paper, we show that combinatorial analysis alone yields an incomplete description of this bout-level structure...
November 6, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/29122270/sound-as-a-supportive-design-intervention-for-improving-health-care-experience-in-the-clinical-ecosystem-a-qualitative-study
#16
REVIEW
Timothy Onosahwo Iyendo
PURPOSE: Most prior hospital noise research usually deals with sound in its noise facet and is based merely on sound level abatement, rather than as an informative or orientational element. This paper stimulates scientific research into the effect of sound interventions on physical and mental health care in the clinical environment. METHODS: Data sources comprised relevant World Health Organization guidelines and the results of a literature search of ISI Web of Science, ProQuest Central, MEDLINE, PubMed, Scopus, JSTOR and Google Scholar...
November 2017: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29120815/3d-neural-tissue-models-from-spheroids-to-bioprinting
#17
REVIEW
Pei Zhuang, Alfred Xuyang Sun, Jia An, Chee Kai Chua, Sing Yian Chew
Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications...
November 7, 2017: Biomaterials
https://www.readbyqxmd.com/read/29119266/civilians-in-world-war-ii-and-dsm-iv-mental-disorders-results-from-the-world-mental-health-survey-initiative
#18
Rochelle Frounfelker, Stephen E Gilman, Theresa S Betancourt, Sergio Aguilar-Gaxiola, Jordi Alonso, Evelyn J Bromet, Ronny Bruffaerts, Giovanni de Girolamo, Semyon Gluzman, Oye Gureje, Elie G Karam, Sing Lee, Jean-Pierre Lépine, Yutaka Ono, Beth-Ellen Pennell, Daniela G Popovici, Margreet Ten Have, Ronald C Kessler
PURPOSE: Understanding the effects of war on mental disorders is important for developing effective post-conflict recovery policies and programs. The current study uses cross-sectional, retrospectively reported data collected as part of the World Mental Health (WMH) Survey Initiative to examine the associations of being a civilian in a war zone/region of terror in World War II with a range of DSM-IV mental disorders. METHODS: Adults (n = 3370) who lived in countries directly involved in World War II in Europe and Japan were administered structured diagnostic interviews of lifetime DSM-IV mental disorders...
November 8, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29119191/interfacial-arrangement-and-phase-transitions-of-pnipam-microgels-with-different-crosslinking-densities
#19
Marcel Rey, Xunan Hou, Jo Sing Julia Tang, Nicolas Vogel
Microgels are colloidal hydrogel particles that exhibit a pronounced softness, which arises from the swollen nature of the constituent polymer network. This softness leads to a substantial deformability of such particles at liquid interfaces, which, in turn translates into a complex phase behaviour that can exhibit a phase transition between a non-close packed and a close packed arrangement. Here, we explore how the degree of swellability and deformability - and therefore the softness of the particles - affects the phase behaviour of microgels at the air/water interface upon compression...
November 9, 2017: Soft Matter
https://www.readbyqxmd.com/read/29116652/avoiding-energy-loss-on-tadf-emitters-controlling-the-dual-conformations-of-d-a-structure-molecules-based-on-the-pseudoplanar-segments
#20
Kai Wang, Cai-Jun Zheng, Wei Liu, Ke Liang, Yi-Zhong Shi, Si-Lu Tao, Chun-Sing Lee, Xue-Mei Ou, Xiao-Hong Zhang
The recent introduction of thermally activated delayed fluorescence (TADF) emitters is regarded as an important breakthrough for the development of high efficiency organic light-emitting devices (OLEDs). The planar D and A groups are generally used to construct TADF emitters for their rigid structure and large steric hindrance. In this work, it is shown that many frequently used nonaromatic (noncontinuous conjugation or without satisfying Hückel's rule) planar segments, such as 9,9-dimethyl-9,10-dihydroacridine, are actually pseudoplanar segments and have two possible conformations-a planar form and a crooked form...
November 8, 2017: Advanced Materials
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