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D Box

Klaus Griesar, John Bessant, Sabine Bernschneider-Reif
The elephant is in the room-a metaphorical idiom for an obvious problem or risk that nobody wants to discuss. This abstract is not intended to be a summary, to reveal major findings, or unveil conclusions. On the contrary, it is aimed to provoke curiosity as to the question of corporate survival. Is there any recipe to be followed for companies to achieve this? The answer comes neither from the modest and traditional study rooms of philosophers nor the recent fact-based studies from the offices (and well-paid opinions) of business consultants...
March 15, 2018: Angewandte Chemie
Erika Virmani, Julian M Rotter, Andre Mähringer, Tobias von Zons, Adelheid Godt, Thomas Bein, Stefan Wuttke, Dana D Medina
Controlled on-surface film growth of porous and crystalline frameworks is a central requisite for incorporating these materials into functional platforms and operational devices. Here, we present the synthesis of thin zirconium-based metal-organic framework (MOF) films by vapor-assisted conversion (VAC). We established protocols adequate for the growth of UiO-66, UiO-66(NH2 ), UiO-67, and UiO-68(NH2 ) as well as the porous interpenetrated Zr-organic framework (PPPP-PIZOF-1) as highly oriented thin films. Through the VAC approach, precursors in a cast solution layer on a bare gold substrate are reacting to form a porous continuous MOF film, oriented along the [111] crystal axis by an exposure to a solvent vapor under elevated temperatures of 100 °C and 3 h reaction times...
March 15, 2018: Journal of the American Chemical Society
Yaomin Chen, Haiyan Wei, Yu Liu, Shusen Zheng
Breast cancer is the most common type of malignant cancer in females. An increasing number of studies have revealed that microRNAs (miR), which belong to a class of small non-coding RNAs, serve an important role in a number of human cancer subtypes. In the present study, the role of miR-194 in breast cancer cells and its underlying mechanisms were investigated. The results demonstrated that the serum levels of miR-194 were significantly higher in patients of the poorly differentiated and well-differentiated groups, compared with in healthy adults...
April 2018: Oncology Letters
Jonathan C Ryan, Alun Hubbard, Marek Stibal, Tristram D Irvine-Fynn, Joseph Cook, Laurence C Smith, Karen Cameron, Jason Box
Albedo-a primary control on surface melt-varies considerably across the Greenland Ice Sheet yet the specific surface types that comprise its dark zone remain unquantified. Here we use UAV imagery to attribute seven distinct surface types to observed albedo along a 25 km transect dissecting the western, ablating sector of the ice sheet. Our results demonstrate that distributed surface impurities-an admixture of dust, black carbon and pigmented algae-explain 73% of the observed spatial variability in albedo and are responsible for the dark zone itself...
March 14, 2018: Nature Communications
Junting Jia, Pincang Zhao, Liqin Cheng, Guangxiao Yuan, Weiguang Yang, Shu Liu, Shuangyan Chen, Dongmei Qi, Gongshe Liu, Xiaoxia Li
BACKGROUND: MADS-box genes are categorized into A, B, C, D and E classes and are involved in floral organ identity and flowering. Sheepgrass (Leymus chinensis (Trin.) Tzvel) is an important perennial forage grass and adapts well to many adverse environments. However, there are few studies on the molecular mechanisms of flower development in sheepgrass, especially studies on MADS-domain proteins. RESULTS: In this study, we cloned 11 MADS-box genes from sheepgrass (Leymus chinensis (Trin...
March 14, 2018: BMC Plant Biology
Zebing Rao, Na Zhang, Ning Xu, Ying Pan, Mengjun Xiao, Junxian Wu, Hong Zhou, Shuo Yang, Yunzi Chen
[This corrects the article on p. 1308 in vol. 8, PMID: 29085368.].
2018: Frontiers in Immunology
Tao Zhou, Xingzhe Yao, Jinfeng Wang, Yingang Feng
Domain of unknown function 61 (DUF61) family proteins widely exist in archaea and the genes of DUF61 proteins in crenarchaea are in an operon containing two genes of box C/D RNA protein complexes. Here we report the solution NMR structure of DUF61 family member protein SSO0941, from the hyperthermophilic archaeon Sulfolobus solfataricus. SSO0941 has a rigid core structure and flexible N- and C-terminal regions as well as a negatively-charged independent C-terminal helix. The core structure consists of N- and C-terminal subdomains, in which the C-terminal subdomain shows significant structural similarity with several nucleic acid binding proteins...
March 8, 2018: Journal of Structural Biology
Amanda K Doughty, Brian J Horton, Nguyen T D Huyen, C Rowdy Ballagh, Ross Corkrey, Geoff N Hinch
We investigated how individuality and lameness altered social organisation by assessing food-directed movement patterns in sheep. One hundred and ninety-six mature Merino ewes were walked in 16 different runs around a 1.1 km track following a food source. Flock position and lameness, were measured and temperament was assessed using an Isolation Box Test. The mean value for the correlations of position between a run and the run preceding it was r = 0.55 ± SEM 0.03. All correlations between runs were positive (r = 0...
March 7, 2018: Behavioural Processes
Brant M Wagener, Parker J Hu, Joo-Yeun Oh, Cilina A Evans, Jillian R Richter, Jaideep Honavar, Angela P Brandon, Judy Creighton, Shannon W Stephens, Charity Morgan, Randal O Dull, Marisa B Marques, Jeffrey D Kerby, Jean-Francois Pittet, Rakesh P Patel
BACKGROUND: Trauma is the leading cause of death and disability in patients aged 1-46 y. Severely injured patients experience considerable blood loss and hemorrhagic shock requiring treatment with massive transfusion of red blood cells (RBCs). Preclinical and retrospective human studies in trauma patients have suggested that poorer therapeutic efficacy, increased severity of organ injury, and increased bacterial infection are associated with transfusion of large volumes of stored RBCs, although the mechanisms are not fully understood...
March 2018: PLoS Medicine
Pierantonio Parmiani, Cristina Lucchetti, Gianfranco Franchi
Skilled reaching is a complex movement in which a forelimb is extended to grasp food for eating. Video-recordings analysis of control rats enables us to distinguish several components of skilled reaching: Orient, approaching the front wall of the reaching box and poking the nose into the slot to locate the food pellet; Transport, advancing the forelimb through the slot to reach-grasp the pellet; and Withdrawal of the grasped food to eat. Although food location and skilled reaching is guided by olfaction, the importance of whisker/nose tactile sense in rats suggests that this too could play a role in reaching behavior...
2018: Frontiers in Behavioral Neuroscience
Liu Yang, Chaofei Ye, Yuting Zhao, Xiaolin Cheng, Yiqiao Wang, Yuan-Qing Jiang, Bo Yang
Overexpression of BnaWGR1 causes ROS accumulation and promotes leaf senescence. BnaWGR1 binds to promoters of RbohD and RbohF and regulates their expression. Manipulation of leaf senescence process affects agricultural traits of crop plants, including biomass, seed yield and stress resistance. Since delayed leaf senescence usually enhances tolerance to multiple stresses, we analyzed the function of specific MAPK-WRKY cascades in abiotic and biotic stress tolerance as well as leaf senescence in oilseed rape (Brassica napus L...
March 6, 2018: Planta
Daniel C Scott, Brenda A Schulman
Liu et al. (2018) report a mathematical model predicting how the cellular repertoire of SCF E3 ligases is assembled by "adaptive exchange on demand," with the limited pool of CUL1 scanning the vast sea of F-box proteins for those with substrates demanding ubiquitylation.
March 1, 2018: Molecular Cell
Elizabeth A Feldman, Christopher D Miller, Sarabeth Wojnowicz, Robert Seabury
Despite a boxed warning, postmarketing reports of deferasirox-associated hepatic injury in patients with chronic transfusions are not well described. Hepatic impairment, including failure, has been reported to occur more frequently in patients older than 55 years and in those with significant comorbidities, including liver cirrhosis and multiorgan failure. In this case report, we describe significant hyperbilirubinemia and acute hepatocellular jaundice related to deferasirox in a 7-year-old female being treated for iron overload secondary to chronic transfusions...
January 2018: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
G Gümüş, A A Agyemang, O Romantsik, R Sandgren, H Karlsson, M Gram, S Vallius, D Ley, D L A van den Hove, M Bruschettini
BACKGROUND: Behavioral testing provides an essential approach in further developing our understanding of brain structure and function. The aim of our study was to outline a more expanded approach to cognition- and anxiety-related behavior in the rabbit. METHODS: Twenty-one 70-day old rabbits (13 female, 8 male) were exposed to open field test, dark-light box test and object recognition testing with variations in inter-trial-interval, olfactory recognition and object location testing...
February 23, 2018: Behavioural Brain Research
Emily Adlam, Adrian Kent
Bob has a black box that emits a single pure state qudit which is, from his perspective, uniformly distributed. Alice wishes to give Bob evidence that she has knowledge about the emitted state while giving him little or no information about it. We show that zero-knowledge evidencing of such knowledge is impossible in quantum relativistic protocols, extending a previous result of Horodecki, Horodecki, and Horodecki. We also show that no such protocol can be both sound and complete. We present a new quantum relativistic protocol which we conjecture to be close to optimal in security against Alice and which reveals little knowledge to Bob, for large dimension d...
February 2, 2018: Physical Review Letters
Keping Cheng, Aijuan Yang, Xiaohui Hu, Dongbo Zhu, Kaizhong Liu
BACKGROUND This study aimed to investigate the therapeutic effect of curcumin in lipopolysaccharide (LPS) induced neonatal acute lung injury (ALI) and the possibly associated molecular mechanisms. MATERIAL AND METHODS ALI neonatal animal model was established by using LPS. Curcumin and/or peroxisome proliferator-activated receptor γ (PPARγ) inhibitor BADGE (bisphenol A diglycidyl ether) were administrated to animals. Lung edema was evaluated by PaO2 and lung wet/dry weight ratio (W/D) measurements. EMSA was used to determine the PPARγ activity...
February 26, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
X Song, E A M Bokkers, P P J van der Tol, P W G Groot Koerkamp, S van Mourik
The objectives of this study were to quantify the error of body weight prediction using automatically measured morphological traits in a 3-dimensional (3-D) vision system and to assess the influence of various sources of uncertainty on body weight prediction. In this case study, an image acquisition setup was created in a cow selection box equipped with a top-view 3-D camera. Morphological traits of hip height, hip width, and rump length were automatically extracted from the raw 3-D images taken of the rump area of dairy cows (n = 30)...
February 21, 2018: Journal of Dairy Science
Ahmadreza Ghaffarizadeh, Randy Heiland, Samuel H Friedman, Shannon M Mumenthaler, Paul Macklin
Many multicellular systems problems can only be understood by studying how cells move, grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many interacting cells as they respond to and influence their microenvironment. The ideal "virtual laboratory" for such multicellular systems simulates both the biochemical microenvironment (the "stage") and many mechanically and biochemically interacting cells (the "players" upon the stage). PhysiCell-physics-based multicellular simulator-is an open source agent-based simulator that provides both the stage and the players for studying many interacting cells in dynamic tissue microenvironments...
February 23, 2018: PLoS Computational Biology
C Fernández, J V Marti, I Pérez-Baena, J L Palomares, C Ibáñez, J V Segarra
The objective of this experiment was to find out the effect of lemon leaves on energy and C-N balances, methane emission, and milk performance in dairy goats. Lemon leaves were used to replace alfalfa as forage in a diet for Murciano-Granadina goats. Ten Murciano-Granadina dairy goats (44.1 ± 4.47 kg of BW) in late lactation (185 ± 7.2 d) were selected in a crossover design experiment, where each goat received two treatments in 2 periods. One group was fed a mixed ration with 450 g of pelleted alfalfa/kg of DM (ALF diet) and, the other group replaced alfalfa with 450 g of pelleted lemon leaves/kg DM (LEM diet)...
February 17, 2018: Journal of Animal Science
Fubao Sun, Michael L Roderick, Graham D Farquhar
There is a growing research interest in the detection of changes in hydrologic and climatic time series. Stationarity can be assessed using the autocorrelation function, but this is not yet common practice in hydrology and climate. Here, we use a global land-based gridded annual precipitation (hereafter P ) database (1940-2009) and find that the lag 1 autocorrelation coefficient is statistically significant at around 14% of the global land surface, implying nonstationary behavior (90% confidence). In contrast, around 76% of the global land surface shows little or no change, implying stationary behavior...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
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