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https://www.readbyqxmd.com/read/29333723/nandrolone-induced-nuclear-accumulation-of-myod-protein-is-mediated-by-numb-a-notch-inhibitor-in-c2c12-myoblasts
#1
Xin-Hua Liu, Rita De Gasperi, William A Bauman, Christopher P Cardozo
Signaling via the androgen receptor (AR) stimulates myogenic progenitor differentiation. In addition, myogenic differentiation factor D (MyoD) and Numb, a Notch inhibitor, play key roles in regulating myogenic differentiation. Nandrolone, an anabolic steroid, upregulates both MyoD and Numb expression in myogenic cells. However, the molecular mechanisms by which MyoD is upregulated by nandrolone are unclear. Moreover, the potential crosstalk between nandrolone, MyoD, and Numb is not well understood. With these considerations in mind, we examined the effects of nandrolone on the expression of MyoD mRNA and protein, and determined the interactions of MyoD and Numb in the presence or absence of nandrolone in differentiating C2C12 myoblasts...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29330344/parathyroid-hormone-related-protein-exhibits-antioxidant-features-in-osteoblastic-cells-through-its-n-terminal-and-osteostatin-domains
#2
S Portal-Núñez, J A Ardura, D Lozano, I Martínez de Toda, M De la Fuente, G Herrero-Beaumont, R Largo, P Esbrit
OBJECTIVES: Oxidative stress plays a major role in the onset and progression of involutional osteoporosis. However, classical antioxidants fail to restore osteoblast function. Interestingly, the bone anabolism of parathyroid hormone (PTH) has been shown to be associated with its ability to counteract oxidative stress in osteoblasts. The PTH counterpart in bone, which is the PTH-related protein (PTHrP), displays osteogenic actions through both its N-terminal PTH-like region and the C-terminal domain...
January 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29329447/congenital-hyperinsulinism-and-hypopituitarism-attributable-to-a-novel-mutation-in-foxa2
#3
Mary Ellen Vajravelu, Jinghua Chai, Bryan Krock, Samuel Baker, David Langdon, Craig Alter, Diva D De León
Context: Persistent hypoglycemia in the newborn period most commonly occurs due to hyperinsulinism. The phenotype of hypoketotic hypoglycemia can also result from pituitary hormone deficiencies, including growth hormone and adrenocorticotropic hormone deficiency. Forkhead box A2 (Foxa2) is a transcription factor shown in mouse models to influence insulin secretion by pancreatic beta cells. In addition, Foxa2 is involved in regulation of pituitary development, and deletions of FOXA2 have been linked to panhypopituitarism...
January 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29324859/magnetic-resonance-spectroscopy-detects-differential-lipid-composition-in-mammary-glands-on-low-fat-high-animal-fat-versus-high-fructose-diets
#4
Dianning He, Devkumar Mustafi, Xiaobing Fan, Sully Fernandez, Erica Markiewicz, Marta Zamora, Jeffrey Mueller, Joseph R Sachleben, Matthew J Brady, Suzanne D Conzen, Gregory S Karczmar
The effects of consumption of different diets on the fatty acid composition in the mammary glands of SV40 T-antigen (Tag) transgenic mice, a well-established model of human triple-negative breast cancer, were investigated with magnetic resonance spectroscopy and spectroscopic imaging. Female C3(1) SV40 Tag transgenic mice (n = 12) were divided into three groups at 4 weeks of age: low fat diet (LFD), high animal fat diet (HAFD), and high fructose diet (HFruD). MRI scans of mammary glands were acquired with a 9...
2018: PloS One
https://www.readbyqxmd.com/read/29320601/surfactant-enhanced-electroosmotic-flushing-in-a-trichlorobenzene-contaminated-clayey-soil
#5
Wenjing Qiao, Shujun Ye, Jichun Wu, Ming Zhang
Remediation of the sites contaminated with organic contaminants, such as chlorobenzenes, remains a challenging issue. Electroosmotic flushing can be a promising approach which is based on mechanism of electrokinetic remediation for removal of organic contaminants from fluids in low-permeability soil. To select an optimum surfactant that can effectively enhance electroosmotic flushing, three common surfactants, Triton X-100 (EK2), Tween 80 (EK3), and a mixture of sodium dodecyl sulfate and Triton X-100 (EK4) buffered with Na2 HPO4 /NaH2 PO4 solution, were tested...
January 10, 2018: Ground Water
https://www.readbyqxmd.com/read/29320387/identification-of-inherited-retinal-disease-associated-genetic-variants-in-11-candidate-genes
#6
Galuh D N Astuti, L Ingeborgh van den Born, M Imran Khan, Christian P Hamel, Béatrice Bocquet, Gaël Manes, Mathieu Quinodoz, Manir Ali, Carmel Toomes, Martin McKibbin, Mohammed E El-Asrag, Lonneke Haer-Wigman, Chris F Inglehearn, Graeme C M Black, Carel B Hoyng, Frans P M Cremers, Susanne Roosing
Inherited retinal diseases (IRDs) display an enormous genetic heterogeneity. Whole exome sequencing (WES) recently identified genes that were mutated in a small proportion of IRD cases. Consequently, finding a second case or family carrying pathogenic variants in the same candidate gene often is challenging. In this study, we searched for novel candidate IRD gene-associated variants in isolated IRD families, assessed their causality, and searched for novel genotype-phenotype correlations. Whole exome sequencing was performed in 11 probands affected with IRDs...
January 10, 2018: Genes
https://www.readbyqxmd.com/read/29314139/validating-genome-wide-associated-signals-for-clinical-mastitis-in-german-holstein-cattle
#7
H Abdel-Shafy, R H Bortfeldt, M Reissmann, G A Brockmann
A validation study for six genomic regions previously identified by a genome-wide association study for somatic cell score was conducted with data of clinical mastitis in German Holstein cattle. Out of 10 tested SNPs, five on chromosomes 6, 13 and 19 were significantly associated with clinical mastitis (P < 0.05). Three SNPs on chromosomes 6 and 19 had the same direction of effect as those previously reported in the initial genome-wide association study for somatic cell score. The other two SNPs on chromosome 13 had opposite effects...
January 4, 2018: Animal Genetics
https://www.readbyqxmd.com/read/29313426/enhancement-of-prodigiosin-synthetase-pigc-production-from-recombinant-escherichia-coli-through-optimization-of-induction-strategy-and-media
#8
Zhongyu You, Suping Zhang, Xiaoxia Liu, Yujie Wang
PigC is a synthetase that catalyzes the condensation of 4-methoxy-2,2'-bipyrrole-5-carboxyaldehyde (MBC) and 2-methyl-3-amylpyrrole (MAP) to produce prodigiosin, which has a wide variety of impressive biological properties. In this study, we optimized PigC production from engineered Escherichia coli BL21(DE3). Investigation of different induction strategies revealed that auto-induction was the most appropriate method for PigC expression. As a result, PigC activity was elevated to 75.7 U/mL, nearly 2.1-fold higher than that with induction by isopropy-β-D-thiogalactoside (IPTG)...
January 9, 2018: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/29308746/the-clinical-and-experimental-research-on-the-treatment-of-endometriosis-with-thiostrepton
#9
Ping Jin, Fei Xiao Chen, Yang Zi Li, Qing Qing Zhang, Jian Zhang
BACKGROUND/OBJECTIVE: Forkhead Box M1 (FOXM1) is frequently activated in tumors. We studied the expression and the possible mechanism of FOXM1 and evaluated the effects of thiostrepton in an endometriotic rat model. STUDY DESIGN: This was a randomized study in a rat model of endometriosis. Fifty female Wistar rats were surgically induced with endometriosis. After 4 weeks of observation, twenty and thirty rats were randomly allocated to an ovariectomized (OVX) group and a treatment group, respectively...
January 7, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29302378/potential-utility-of-fdg-pet-ct-as-a-non-invasive-tool-for-monitoring-local-immune-responses
#10
Seungho Lee, Seohee Choi, Sang Yong Kim, Mi Jin Yun, Hyoung-Il Kim
Purpose: The tumor microenvironment is known to be associated with the metabolic activity of cancer cells and local immune reactions. We hypothesized that glucose metabolism measured by 2-deoxy-2-(18F)fluoro-D-glucose (18F-FDG) positron emission tomography (PET)-computed tomography (CT) (18F-FDG PET-CT) would be associated with local immune responses evaluated according to the presence of tumor infiltrating lymphocytes (TILs). Materials and Methods: We retrospectively reviewed 56 patients who underwent 18F-FDG PET-CT prior to gastrectomy...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29290241/universal-suicide-risk-screening-in-the-hospital-setting-still-a-pandora-s-box
#11
EDITORIAL
Lisa M Horowitz, Edwin D Boudreaux, Michael Schoenbaum, Maryland Pao, Jeffrey A Bridge
No abstract text is available yet for this article.
January 2018: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/29289764/unravelling-complex-primary-care-programmes-to-maintain-independent-living-in-older-people-a-systematic-overview
#12
L C Smit, M J Schuurmans, J W Blom, I N Fabbricotti, A P D Jansen, G I J M Kempen, R Koopmans, W M Looman, R J F Melis, S F Metzelthin, E P Moll van Charante, M E Muntinga, F G H Ruikes, S L W Spoorenberg, J J Suijker, K Wynia, J Gussekloo, N J De Wit, N Bleijenberg
OBJECTIVE: Complex interventions are criticized for being a 'black box', which makes it difficult to determine why they succeed or fail. Recently, nine proactive primary care programmes aiming to prevent functional decline in older adults showed inconclusive effects. The aim of this study was to systematically unravel, compare and synthesize the development and evaluation of nine primary care programs within a controlled trial to further improve the development and evaluation of complex interventions...
December 28, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29288908/the-role-of-military-footwear-and-workload-on-ground-reaction-forces-during-a-simulated-lateral-ankle-sprain-mechanism
#13
Jeffrey D Simpson, Hunter DeBusk, Christopher Hill, Adam Knight, Harish Chander
BACKGROUND: Ankle sprains are a common orthopedic injury in military populations, which may be attributed to occupational demands and footwear. Minimalist military boots have become popular, but their influence on ground reaction force (GRF) attenuation capabilities during an ankle inversion perturbation are unknown. Therefore, the purpose of this study was to examine potential differences in GRFs during an ankle inversion perturbation in a standard issue (STN) and minimalist military boot (MIN) before and after a simulated military workload...
November 22, 2017: Foot
https://www.readbyqxmd.com/read/29285741/effects-of-polygonum-cuspidatum-on-ampk-foxo3%C3%AE-signaling-pathway-in-a-rat-model-of-uric-acid-induced-renal-damage
#14
Wei-Guo Ma, Jie Wang, Xiang-Wei Bu, Hong-Hong Zhang, Jian-Ping Zhang, Xiao-Xu Zhang, Yu-Xi He, Da-Li Wang, Zheng-Ju Zhang, Feng-Xian Meng
OBJECTIVE: To observe the effects of Polygonum cuspidatum (PC) on adenosine 5'-monophosphateactivated protein kinase (AMPK), forkhead box O3α (FOXO3α), Toll-like receptor-4 (TLR4), NACHT, LRR and PYD domains-containing protein 3 (NLRP3), and monocyte chemoattractant protein-1 (MCP-1) expression in a rat model of uric acid-induced renal damage and to determine the molecular mechanism. METHODS: A rat model of uric acid-induced renal damage was established, and rats were randomly divided into a model group, a positive drug group, and high-, medium-, and low-dose Chinese medicine (CM) PC groups (n=12 per group)...
December 28, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29284139/coordinated-d-cyclin-foxd1-activation-drives-mitogenic-activity-of-sonic-hedgehog-signaling-pathway
#15
Dustin M Fink, Miranda R Sun, Galen W Heyne, Joshua L Everson, Hannah M Chung, Sookhee Park, Michael D Sheets, Robert J Lipinski
Sonic Hedgehog (Shh) signaling plays key regulatory roles in embryonic development and postnatal homeostasis and repair. Modulation of the Shh pathway is known to cause malformations and malignancies associated with dysregulated tissue growth. However, our understanding of the molecular mechanisms by which Shh regulates cellular proliferation is incomplete. Here, using mouse embryonic fibroblasts, we demonstrate that the Forkhead box gene Foxd1 is transcriptionally regulated by canonical Shh signaling and required for downstream proliferative activity...
December 25, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29284022/a-transcriptomics-approach-uncovers-novel-roles-for-poly-adp-ribosyl-ation-in-the-basal-defense-response-in-arabidopsis-thaliana
#16
Amy G Briggs, Lori C Adams-Phillips, Brian D Keppler, Sophia G Zebell, Kyle C Arend, April A Apfelbaum, Joshua A Smith, Andrew F Bent
Pharmacological inhibition of poly(ADP-ribose) polymerase (PARP) or loss of Arabidopsis thaliana PARG1 (poly(ADP-ribose) glycohydrolase) disrupt a subset of plant defenses. In the present study we examined the impact of altered poly(ADP-ribosyl)ation on early gene expression induced by the microbe-associate molecular patterns (MAMPs) flagellin (flg22) and EF-Tu (elf18). Stringent statistical analyses and filtering identified 178 genes having MAMP-induced mRNA abundance patterns that were altered by either PARP inhibitor 3-aminobenzamide (3AB) or PARG1 knockout...
2017: PloS One
https://www.readbyqxmd.com/read/29280233/operant-self-administration-of-pregabalin-in-a-mouse-model-of-neuropathic-pain
#17
S A Bura, D Cabañero, R Maldonado
BACKGROUND: Pregabalin is a first-line agent for neuropathic pain treatment whose abuse liability remains controversial. Surprisingly, studies exploring the reinforcing properties of pregabalin in operant mouse models are missing. METHODS: We evaluated the acquisition of operant pregabalin self-administration in mice exposed to a partial sciatic nerve ligation (PSNL) or a sham operation. After surgery, mice were trained in operant boxes to intravenously self-administer pregabalin at 1...
December 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29249295/eating-during-hemodialysis-treatment-a%C3%A2-consensus-statement-from-the-international-society-of-renal-nutrition-and-metabolism
#18
REVIEW
Brandon M Kistler, Debbie Benner, Jerrilynn D Burrowes, Katrina L Campbell, Denis Fouque, Giacomo Garibotto, Joel D Kopple, Csaba P Kovesdy, Connie M Rhee, Alison Steiber, Peter Stenvinkel, Pieter Ter Wee, Daniel Teta, Angela Y M Wang, Kamyar Kalantar-Zadeh
Poor nutritional status and protein-energy wasting are common among maintenance dialysis patients and associated with unfavorable outcomes. Providing foods, meal trays, snack boxes, and/or oral nutritional supplements during hemodialysis can improve nutritional status and might also reduce inflammation, enhance health-related quality of life, boost patient satisfaction, and improve survival. Potential challenges include postprandial hypotension and other hemodynamic instabilities, aspiration risk, gastrointestinal symptoms, hygiene issues, staff burden, reduced solute removal, and increased costs...
January 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29247051/viruses-causing-lower-respiratory-symptoms-in-young-children-findings-from-the-orchid-birth-cohort
#19
Mohinder Sarna, Stephen B Lambert, Theo P Sloots, David M Whiley, Asma Alsaleh, Lebogang Mhango, Seweryn Bialasiewicz, David Wang, Michael D Nissen, Keith Grimwood, Robert S Ware
INTRODUCTION: Viral acute respiratory infections (ARIs) cause substantial child morbidity. Sensitive molecular-based assays aid virus detection, but the clinical significance of positive tests remains uncertain as some viruses may be found in both acutely ill and healthy children. We describe disease-pathogen associations of respiratory viruses and quantify virus-specific attributable risk of ARIs in healthy children during the first 2 years of life. METHODS: One hundred fifty-eight term newborn babies in Brisbane, Australia, were recruited progressively into a longitudinal, community-based, birth cohort study conducted between September 2010 and October 2014...
December 15, 2017: Thorax
https://www.readbyqxmd.com/read/29236588/topical-glycyrrhizin-is-therapeutic-for-pseudomonas-aeruginosa-keratitis
#20
Sandamali A Ekanayaka, Sharon A McClellan, Ronald P Barrett, Linda D Hazlett
PURPOSE: Glycyrrhizin (GLY), an inhibitor of high-mobility group box 1 (HMGB1) protects prophylactically against Pseudomonas aeruginosa keratitis. However, the therapeutic potential of GLY to enhance an antibiotic has not been tested and is our purpose. METHODS: C57BL/6 mice (B6) were infected with a clinical isolate (KEI 1025) of P. aeruginosa and treated topically at 6 h postinfection (p.i.) with GLY or phosphate-buffered saline (PBS). Clinical scores, photography with a slit lamp, enzyme-linked immunosorbent assay, myeloperoxidase assay, bacterial plate counts, histopathology, reactive oxygen/nitrogen species (ROS/RNS) assays, and in vitro macrophage (Mφ) stimulation assays were used to assess effects of GLY treatment...
December 13, 2017: Journal of Ocular Pharmacology and Therapeutics
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