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pain neuromatrix

Huynh Giao Ly, Patrick Dupont, Koen Van Laere, Inge Depoortere, Jan Tack, Lukas Van Oudenhove
BACKGROUND: Rapid gastric balloon distension to discomfort threshold activates the "pain neuromatrix" and deactivates exteroceptive sensory and "default mode network" regions. However, little is known about brain mechanisms underlying tolerance of meal-induced gastric distension. We aimed to directly compare brain responses to gradual balloon distension and intragastric nutrient infusion and to explore the role of differential gut peptide release in these responses. MATERIALS AND METHODS: Brain responses to balloon- and nutrient-induced distension (to individually titrated pain or maximal satiation threshold) were measured in 15 healthy volunteers using H2(15)O-PET on 2 separate days in counterbalanced order...
September 14, 2016: NeuroImage
Enrico Facco
Hypnosis is a physiological mind activity characterized by focused attention, absorption, dissociation and plastic imagination. In the early 19th century, several hundred surgical interventions were described with hypnosis as the sole anesthetic, in an epoch when no anesthetic drugs were available; then hypnosis was prejudicially abandoned and forgotten after their introduction. In the past two decades, an increasing number of studies on hypnosis has shown its capacity to modify the activity of the prefrontal cortex, default mode network and pain neuromatrix (including the anterior cingulate cortex, amygdala, thalamus, insula and somatosensory cortex) and increase pain threshold up to the level of surgical anesthesia...
August 30, 2016: Minerva Anestesiologica
Daniele Di Lernia, Silvia Serino, Pietro Cipresso, Giuseppe Riva
Pain is a complex and multidimensional perception, embodied in our daily experiences through interoceptive appraisal processes. The article reviews the recent literature about interoception along with predictive coding theories and tries to explain a missing link between the sense of the physiological condition of the entire body and the perception of pain in chronic conditions, which are characterized by interoceptive deficits. Understanding chronic pain from an interoceptive point of view allows us to better comprehend the multidimensional nature of this specific organic information, integrating the input of several sources from Gifford's Mature Organism Model to Melzack's neuromatrix...
2016: Frontiers in Neuroscience
Adriaan Louw, Stephen G Schmidt
In recent years there has been an increased interest in pain neuroscience in physical therapy.1,2 Emerging pain neuroscience research has challenged prevailing models used to understand and treat pain, including the Cartesian model of pain and the pain gate.2-4 Focus has shifted to the brain's processing of a pain experience, the pain neuromatrix and more recently, cortical reorganisation of body maps.2,3,5,6 In turn, these emerging theories have catapulted new treatments, such as therapeutic neuroscience education (TNE)7-10 and graded motor imagery (GMI),11,12 to the forefront of treating people suffering from persistent spinal pain...
July 2015: Journal of Manual & Manipulative Therapy
Ricardo Cárdenas Fernández
The gate control theory of pain, introduced by Melzack and Wall in 1965, led the way in pain research during the second half of the 20th century. Eventually, the observation of pain-related phenomena which the theory could not satisfactorily explain propelled Melzack to develop a new concept, the neuromatrix, which considers as participants in the pain transmission and modulation system, certain brain areas not traditionally associated with the pain experience. This concept places equal importance on the sensory, affective and cognitive aspects of pain, helping the advancement of novel diagnostic and therapeutic approaches in different clinical pain conditions...
June 2015: Investigación Clínica
B Vaseghi, M Zoghi, S Jaberzadeh
The primary aim of this study was to assess the effects of cathodal transcranial direct current stimulation (c-tDCS) over cortical regions of the pain neuromatrix, including the primary motor (M1), sensory (S1) and dorsolateral prefrontal (DLPFC) cortices on M1/S1 excitability, sensory (STh), and pain thresholds (PTh) in healthy adults. The secondary aim was to evaluate the placebo effects of c-tDCS on induced cortical and behavioural changes. Before, immediately after and 30 min after c-tDCS the amplitude of N20-P25 components of somatosensory evoked potentials (SEPs) and peak-to-peak amplitudes of motor evoked potentials (MEPs) were measured under four different experimental conditions...
October 2015: European Journal of Neuroscience
R Gopalakrishnan, R C Burgess, E B Plow, D P Floden, A G Machado
Pain anticipation plays a critical role in pain chronification and results in disability due to pain avoidance. It is important to understand how different sensory modalities (auditory, visual or tactile) may influence pain anticipation as different strategies could be applied to mitigate anticipatory phenomena and chronification. In this study, using a countdown paradigm, we evaluated with magnetoencephalography the neural networks associated with pain anticipation elicited by different sensory modalities in normal volunteers...
September 24, 2015: Neuroscience
Bradford W Fenton, Elim Shih, Jessica Zolton
Pain is a significant national burden in terms of patient suffering, expenditure and lost productivity. Understanding pain is fundamental to improving evaluation, treatment and innovation in the management of acute and persistent pain syndromes. Pain perception begins in the periphery, and then ascends in several tracts, relaying at different levels. Pain signals arrive in the thalamus and midbrain structures which form the pain neuromatrix, a constantly shifting set of networks and connections that determine conscious perception...
2015: Pain Management
Stuart W G Derbyshire
Functional imaging has comprehensively demonstrated that pain involves a number of cortical regions that are often collectively referred to as the pain neuromatrix. This neuromatrix is assumed to be necessary to process the sensory, affective, and cognitive components of pain. Patients who report pain in the apparent absence of injury or disease may experience their symptoms because of dysfunction in one or more components of the pain neuromatrix. Two articles in this edition of Psychosomatic Medicine explore that possibility and provide evidence of altered neural connectivity and activation within components of the pain neuromatrix in patients with low back pain and irritable bowel syndrome...
July 2014: Psychosomatic Medicine
Stefano Triberti, Claudia Repetto, Giuseppe Riva
The experience of pain is affected by remarkable psychological factors. The concept of neuromatrix suggests that pain is an amalgam of affect, cognition, and sensation mediated through diverse brain regions. Moreover, the experience of pain appears to be reduced by environmental stimuli that drive attention away from the noxious events. Accordingly, immersion in a computer-generated, three-dimensional virtual environment has been used as an efficient distraction tool in a number of studies on pain management...
June 2014: Cyberpsychology, Behavior and Social Networking
F Zangrando, T Paolucci, M C Vulpiani, M Lamaro, R Isidori, V M Saraceni
BACKGROUND: The "neuromatrix" theory of Melzack and the studies of Decety on motor imagery have opened the way to an alternative rehabilitation method in chronic pain. AIM: To evaluate the role of motor imagery in chronic shoulder pain rehabilitation. DESIGN: Case report. SETTING: University outpatient rehabilitation. POPULATION: A 49-year-old female with chronic shoulder pain. METHODS: Neurocognitive approach, which involves the use of a new tool called "naval battle" to achieve chronic pain relief as assessed by the Visual Analogic Scale (VAS) and McGill Pain Questionnaire (MPQ)...
February 2014: European Journal of Physical and Rehabilitation Medicine
Joseph V Pergolizzi, Robert B Raffa, Robert Taylor
The progression of acute to chronic pain, also known as pain chronification, remains incompletely understood. Biologic factors involved in this transition include central sensitization, neuroplastic changes, altered pain modulation, and changes to the "neuromatrix." Chronic pain may involve irreversible pathophysiologic changes, so interrupting the cascade of events that allows acute pain to advance to chronic pain is of crucial importance. This involves recognition and prompt treatment of acute pain, better awareness and application of evidence-based guidelines on pain management by all clinicians (not just pain specialists), and patient education...
March 2014: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
Alexander Ritter, Thomas Weiss, Marcel Franz, Marc H E de Lussanet
It is well established that humans can recognize high-level aspects from point-light biological motion, such as gender and mood. If the task is to judge the manipulated weight we expected that sensorimotor regions should be recruited in the brain. Moreover, we have recently shown that chronic pain in a limb that is involved in the presented movement disturbs the weight judgment. We therefore hypothesized that some cortical regions usually activated during the processing of pain will also be activated while viewing point-light biological motion with the instruction to judge the manipulated weights...
October 2013: Human Movement Science
Ela B Plow, Donald A Malone, Andre Machado
BACKGROUND: Chronic neuropathic pain in thalamic pain syndrome remains intractable. Its poor response is ascribed to destruction of the integrated neuromatrix in experience of pain. Deep brain stimulation is a promising technique to modulate activity of implicated structures. However, traditional approaches targeting sensori-motor substrates have failed to affect disability. The offending lesion in thalamic pain syndrome that almost invariably destroys sensory pain pathways may render these classical approaches ineffective...
2013: Trials
Suzanne B Hanser
Music therapy is a service that has become more prevalent as an adjunct to medical practice-as its evidence base expands and music therapists begin to join the cardiology team in every phase of care, from the most serious cases to those maintaining good heart health. Although applications of music medicine, primarily listening to short segments of music, are capable of stabilizing vital signs and managing symptoms in the short-term, music therapy interventions by a qualified practitioner are showing promise in establishing deeper and more lasting impact...
January 2014: Cardiology in Review
Andre G Machado, Kenneth B Baker, Ela Plow, Donald A Malone
OBJECTIVES: To review the current state of cerebral stimulation for neuropathic pain and to propose that cerebral stimulation should aim also at the affective sphere of chronic pain rather than solely focusing on the primary sensory-discriminative sphere. METHODS: The past and current goals of cerebral stimulation are reviewed as well as its limitations. A novel deep brain stimulation approach is proposed to evaluate this conceptual shift from somatosensory to affective sphere of pain targeting...
November 2013: Neuromodulation: Journal of the International Neuromodulation Society
Stefan Duschek, Tanja Mannhart, Andreas Winkelmann, Karim Merzoug, Natalie S Werner, Daniel Schuepbach, Pedro Montoya
OBJECTIVES: Increased cerebral blood flow during processing of acute pain has repeatedly been observed in fibromyalgia syndrome. The study investigated the time dynamics of the pain-related hemodynamic response in fibromyalgia using transcranial Doppler sonography. METHODS: In 25 women with fibromyalgia and 25 healthy participants, blood flow velocities in the anterior and middle cerebral arteries of both hemispheres were recorded, while heat stimuli of 45°C were applied to their forearms...
October 2012: Psychosomatic Medicine
Lawrence Leung
BACKGROUND: Pain remains one of the top five reasons for consultations in general practice, presenting either alone or as comorbidity. The World Health Organization (WHO) analgesic ladder proposed in 1986 has been the cornerstone of pain management, but is often inadequate in daily practice, especially when dealing with the diverse nature and etiology of various pain conditions. There is a need for a better concept which is universally applicable that acknowledges the value of, and need for, other domains of treatment for pain...
2012: Journal of Primary Health Care
Christoph Schmidt, Thomas Weiss, Christian Komusiewicz, Herbert Witte, Lutz Leistritz
Network motifs, overrepresented small local connection patterns, are assumed to act as functional meaningful building blocks of a network and, therefore, received considerable attention for being useful for understanding design principles and functioning of networks. We present an extension of the original approach to network motif detection in single, directed networks without vertex labeling to the case of a sample of directed networks with pairwise different vertex labels. A characteristic feature of this approach to network motif detection is that subnetwork counts are derived from the whole sample and the statistical tests are adjusted accordingly to assign significance to the counts...
2012: Computational and Mathematical Methods in Medicine
Ela B Plow, Alvaro Pascual-Leone, Andre Machado
UNLABELLED: Chronic neuropathic pain is one of the most prevalent and debilitating disorders. Conventional medical management, however, remains frustrating for both patients and clinicians owing to poor specificity of pharmacotherapy, delayed onset of analgesia and extensive side effects. Neuromodulation presents as a promising alternative, or at least an adjunct, as it is more specific in inducing analgesia without associated risks of pharmacotherapy. Here, we discuss common clinical and investigational methods of neuromodulation...
May 2012: Journal of Pain: Official Journal of the American Pain Society
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