Christian A Faig, Gloria H K Kim, Alison D Do, Zoë Dworsky-Fried, Jesse Jackson, Anna M W Taylor
The anterior cingulate cortex (ACC) is critical for the perception and unpleasantness of pain.1 , 2 , 3 , 4 , 5 , 6 It receives nociceptive information from regions such as the thalamus and amygdala and projects to several cortical and subcortical regions of the pain neuromatrix.7 , 8 ACC hyperexcitability is one of many functional changes associated with chronic pain, and experimental activation of ACC pyramidal cells produces hypersensitivity to innocuous stimuli (i.e., allodynia).9 , 10 , 11 , 12 , 13 , 14 A less-well-studied projection to the ACC arises from a small forebrain region, the claustrum...
April 6, 2024: Current Biology: CB