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Platelet Volume

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https://www.readbyqxmd.com/read/28727479/extracellular-chloride-is-required-for-efficient-platelet-aggregation
#1
Kirk A Taylor, Darren G S Wilson, Matthew T Harper, Nicholas Pugh
Anion channels perform a diverse range of functions and have been implicated in ATP release, volume regulation, and phosphatidylserine exposure. Platelets have been shown to express several anion channels but their function is incompletely understood. Due to a paucity of specific pharmacological blockers, we investigated the effect of extracellular chloride substitution on platelet activation using aggregometry and flow cytometry. In the absence of extracellular chloride, we observed a modest reduction of the maximum aggregation response to thrombin or collagen-related peptide...
July 20, 2017: Platelets
https://www.readbyqxmd.com/read/28727131/evaluation-of-the-hematologic-system-as-a-marker-of-subclinical-inflammation-in-hyperemesis-gravidarum-a-case-control-study
#2
Fatma Beyazit, Filiz Halici Öztürk, Eren Pek, Mesut Abdülkerim Ünsal
OBJECTIVES: Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have been shown to reflect inflammatory burden and disease activity in several disorders. This study aimed to determine the diagnostic value of these hematological parameters for HEG. MATERIAL AND METHODS: A total of 54 HEG patients and 58 age- and gestational-age-matched control subjects were studied...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28727130/the-utility-of-maternal-mean-platelet-volume-levels-for-early-onset-neonatal-sepsis-prediction-of-term-infants
#3
Yasemin Cekmez, Merve Dizdar Güleçoğlu, Cemile Özcan, Leyla Karadeniz, Gürkan Kıran
OBJECTIVES: This study is aimed to evaluate the role of maternal mean platelet volume (MPV) levels for antenatal prediction marker of early onset neonatal sepsis in term infants born to mothers who have low infection risk. MATERIAL AND METHODS: A total of 62 pregnant women who gave birth in our hospital and whose neonates were admitted to a third level Neonatal Intensive Care Unit due to confirmed neonatal sepsis between January 2010 and May 2016 were selected as a study group...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28725968/microglial-mediated-pdgf-cc-activation-increases-cerebrovascular-permeability-during-ischemic-stroke
#4
Enming Joseph Su, Chunzhang Cao, Linda Fredriksson, Ingrid Nilsson, Christina Stefanitsch, Tamara K Stevenson, Juanjuan Zhao, Margret Ragsdale, Yu-Yo Sun, Manuel Yepes, Chia-Yi Kuan, Ulf Eriksson, Dudley K Strickland, Daniel A Lawrence, Li Zhang
Treatment of acute ischemic stroke with the thrombolytic tissue plasminogen activator (tPA) can significantly improve neurological outcomes; however, thrombolytic therapy is associated with an increased risk of intra-cerebral hemorrhage (ICH). Previously, we demonstrated that during stroke tPA acting on the parenchymal side of the neurovascular unit (NVU) can increase blood-brain barrier (BBB) permeability and ICH through activation of latent platelet-derived growth factor-CC (PDGF-CC) and signaling by the PDGF receptor-α (PDGFRα)...
July 19, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28723699/intraoperative-bleeding-in-patients-with-osteogenesis-imperfecta-type-iii-treated-by-fassier-duval-femoral-rodding-analysis-of-risk-factors
#5
Pietro Persiani, Maria V Pesce, Lorena Martini, Filippo M Ranaldi, Patrizia D'Eufemia, Anna Zambrano, Mauro Celli, Ciro Villani
The surgical treatment of osteogenesis imperfecta (OI) is negatively influenced by clinical features such as osteoporosis, limb deformities and bone changes caused by bisphosphonate therapy. Blood loss during femoral nailing surgeries in patients with OI is a serious problem. Platelet anomalies have been associated with an elevation of the serum pyrophosphate originating from the platelets during clotting, even if the causality with the platelet dysfunction has not yet been established. To identify predictive risk factors regarding intraoperative bleeding, a retrospective analysis was conducted on 23 patients aged between 6 and 13 years, affected by OI type III, who were treated to correct femoral deformities or to perform an osteosynthesis for femoral shaft fractures, using the Fassier-Duval telescopic nail...
July 18, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28721136/mean-platelet-volume-changes-before-and-after-glycated-hemoglobin-hba1c-improvement-in-a-large-study-population
#6
Yasar Sertbas, Meltem Sertbas, Nalan Okuroglu, Mehmet Akif Ozturk, Kerem Yigit Abacar, Ali Ozdemir
INTRODUCTION: Diabetes mellitus (DM) is a metabolic disorder associated with both microvascular and macrovascular complications. Mean platelet volume (MPV) is a marker of platelet activity, which plays a major role in the development of vascular complications of DM. The aim of this study is to compare the MPV levels before and after the decrease of glycated hemoglobin (HbA1c) levels in a large diabetic population. MATERIAL AND METHODS: This was a retrospective study conducted on type 2 diabetic patients from the outpatient clinic for 1 year between 2014 and 2015 with the participation of 595 diabetic patients...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28718063/new-insights-on-platelets-and-platelet-derived-microparticles-in-systemic-lupus-erythematosus
#7
REVIEW
Marc Scherlinger, Vanja Sisirak, Christophe Richez, Estibaliz Lazaro, Pierre Duffau, Patrick Blanco
PURPOSE OF REVIEW: Current knowledge on the role of platelets and platelet-derived microparticles (PMPs) on the immune system has been fast-growing. Systemic lupus erythematosus (SLE) is a systemic auto-immune disorder characterized by a loss of tolerance toward nuclear auto-antigens. Although recent studies allowed a better understanding of SLE pathogenesis, there is an urgent need for the development of new treatments and the identification of new biomarkers to assess the disease activity...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28717372/comparison-of-platelet-number-and-function-between-nonalcoholic-fatty-liver-disease-and-normal-individuals
#8
Zeinab Saremi, Mahboobe Rastgoo, Mahyar Mohammadifard, Bita Bijari, Ehsan Akbari
BACKGROUND: There is interest about the role of platelet (PLT) number and function in nonalcoholic fatty liver disease (NAFLD). NAFLD patients have abnormalities of PLT number and function, especially mean platelet volume (MPV) which is known as a novel biomarker for atherosclerosis. We decided to compare PLT number and function between NAFLD and healthy participants. MATERIALS AND METHODS: In this case-control study, two groups of patients (65 cases with NAFLD and 65 cases without NAFLD) were included consecutively...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28716649/blood-platelet-volume-represents-a-novel-prognostic-factor-in-non-metastatic-renal-cell-carcinoma-patients-and-improves-the-predictive-ability-of-established-prognostic-scores
#9
Maximilian Seles, Florian Posch, Georg P Pichler, Thomas Gary, Karl Pummer, Richard Zigeuner, Georg C Hutterer, Martin Pichler
PURPOSE: The average size of blood platelets determined by the mean platelet volume (MPV), might represent a biologically meaningful parameter in carcinogenesis and potentially serve as novel prognostic biomarker in renal cell carcinoma (RCC). MATERIALS AND METHODS: In this retrospective analysis (n=652) we evaluated the potential prognostic value of MPV and its ability to improve existing risk assessment tools used in adjuvant clinical trials in non-metastatic RCC...
July 14, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28715072/association-of-mean-platelet-volume-with-presence-of-non-viable-myocardium-in-ischemic-cardiomyopathy
#10
Semi Ozturk, Ahmed Seyfettin Gürbüz, Süleyman Çağan Efe, Mehmet Fatih Yılmaz, Özden Savaş Den Hartigh, Ferahnaz Çınaral Sayın, Cevat Kırma
BACKGROUND AND AIMS: Parameters derived from complete blood count such as mean platelet volume (MPV), neutrophil to lymphocyte (NLR), platelet to lymphocyte (PLR) are recently proposed as measures of inflammation in addition to C-reactive protein (CRP), a classical inflammatory marker. Significant association of these parameters with atherosclerosis and complications have increasingly been reported. Our aim is to evaluate relationship between these parameters and presence of myocardial viability assessed with positron emission tomography (PET) in patients with ischemic cardiomyopathy...
July 17, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28714524/simple-platelet-markers-mean-platelet-volume-and-congestive-heart-failure-coexistent-with-periodontal-disease-pilot-studies
#11
Maciej R Czerniuk, Zbigniew Bartoszewicz, Iwona Dudzik-Niewiadomska, Tomasz Pilecki, Renata Górska, Krzysztof J Filipiak
BACKGROUND: Conducted pilot study concerning mean platelet volume parameter among patients suffering from congestive heart failure and periodontal disease. METHODS: Examination of dynamic changes of platelet and periodontal markers in group of 50 patients before and an average of 6 months subsequent to professional periodontal treatment. RESULTS: Both platelet and periodontal parameters decreased after periodontal treatment, what is more, the decrease of mean platelet volume (MPV) value due to periodontal disease/mm improvement was shown to be statistically significant (p = 0...
July 17, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28713869/association-of-anisocytosis-with-markers-of-immune-activation-and-exhaustion-in-treated-hiv
#12
Sadeer G Al-Kindi, David A Zidar, Grace A McComsey, Chris T Longenecker
BACKGROUND: Treated HIV infection is associated with heightened inflammation which can contribute to increased risk of cardiovascular disease (CVD). We have previously shown that anisocytosis, as measured by red cell distribution width (RDW), is independently associated with prevalent CVD in people living with HIV (PLHIV). In this study, we sought to identify immune correlates of RDW in PLHIV receiving antiretroviral therapy. METHODS: We performed a cross-sectional and longitudinal analysis of 147 virally-suppressed PLHIV, who had LDL < 130 mg/dL and evidence of heightened inflammation, in a randomized trial of statin therapy...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28711077/acute-kidney-injury-in-pregnancy
#13
Belinda Jim, Vesna D Garovic
Pregnancy-related acute kidney injury (AKI) has declined in incidence in the last three decades, although it remains an important cause of maternal and fetal morbidity and mortality. Pregnancy-related causes of AKI such as preeclampsia, acute fatty liver of pregnancy, HELLP (Hemolysis, Elevated Liver function tests, Low Platelets) syndrome, and the thrombotic microangiopathies (thrombotic thrombocytopenic purpura, atypical hemolytic-uremic syndrome [HUS]) exhibit overlapping features and often present as diagnostic dilemmas...
July 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28708902/factors-associated-with-contralateral-liver-hypertrophy-after-unilateral-radioembolization-for-hepatocellular-carcinoma
#14
Juliane Goebel, Maximilian Sulke, Andrea Lazik-Palm, Thomas Goebel, Alexander Dechêne, Alexander Bellendorf, Stefan Mueller, Lale Umutlu, Jens Theysohn
INTRODUCTION: Radioembolization for the treatment of hepatocellular carcinoma (HCC) induces liver volume changes referred to as "atrophy-hypertrophy complex". The aim of this study was to investigate lobar liver volume changes after unilateral radioembolization and to search for factors associated with hypertrophy of the untreated lobe. MATERIALS AND METHODS: Seventy-five patients were retrospectively evaluated. Inclusion criteria were: (1) right-lobar radioembolization for unresectable unilateral HCC, (2) available liver computed tomography scans before, 1, 3, and at least 6 months after radioembolization...
2017: PloS One
https://www.readbyqxmd.com/read/28708187/strain-induced-insulator-to-conductor-transition-in-conducting-polymer-composites-from-the-auxetic-behaviour-of-hierarchical-microstructures
#15
Indu Chanchal Polpaya, C Lakshmana Rao, Susy Varughese
Above their 'percolation threshold', intrinsically conducting polymer (ICP) based composites exhibit an increase or decrease in conductivity with strain. However, in this study we report an increase in conductivity and an associated insulator-to-conductor transition observed in certain conducting polymer composites below their percolation threshold under uniaxial tensile strain, thereby shifting the percolation to lower volume fractions. The 'auxetic behaviour' possible in certain types of 'hierarchical' microstructures is shown to be responsible for such changes in the polyaniline (PANI) composites studied...
July 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28700514/low-volume-high-intensity-interval-versus-continuous-endurance-training-effects-on-hematological-and-cardiorespiratory-system-adaptations-in-professional-canoe-polo-athletes
#16
Mohsen Sheykhlouvand, Mohammadali Gharaat, Erfan Khalili, Hamid Agha-Alinejad, Farhad Rahmaninia, Hamid Arazi
The aim of this study was to compare the effect of two paddling-based high-intensity interval training (HIIT) and continuous endurance training (CET) on hematological, immunological, and cardiorespiratory adaptations in professional canoe polo athletes. Twenty one male canoe polo athletes were randomly divided into one of three groups (N=7): 1) HIIT with variable intensity (VIHIIT) (6×60-second at 100,110,120,130,130, 130,120,110,100% vV[Combining Dot Above]O2peak from 1 to 9 session respectively, 1:3 work to recovery ratio); 2) HIIT with variable volume (VVHIIT) (6,7,8,9,9,9,8,7,6 repetitions/session from 1 to 9 session respectively)×60-second at lowest velocity that elicited V[Combining Dot Above]O2peak (vV[Combining Dot Above]O2peak), 1:3 work to recovery ratio); and 3) the CET group performed 3 times × 60 min paddling sessions (75% vV[Combining Dot Above]O2peak) per week for 3 weeks...
July 8, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28700408/three-versus-four-factor-prothrombin-complex-concentrates-for-factor-based-resuscitation-in-a-porcine-hemorrhagic-shock-model
#17
Donald Michael Moe, Michael Scott Lallemand, John Mason McClellan, Joshua Porter Smith, Shannon T Marko, Matthew J Eckert, Matthew J Martin
BACKGROUND: Bleeding is a leading cause of preventable death following severe injury. Prothrombin complex concentrates (PCC) treat inborn coagulation disorders and reverse oral anticoagulants, but are proposed for use in "factor-based" resuscitation strategies. Few studies exist for this indication in acidosis, or that compare 3-factor (3PCC) versus 4-factor (4PCC) products. We aimed to assess and compare their safety and efficacy in a porcine model of severe hemorrhagic shock and coagulopathy...
July 12, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28699842/mean-platelet-volume-measurements-should-not-be-used-as-an-indicator-of-platelet-function
#18
Cengiz Beyan, Esin Beyan
No abstract text is available yet for this article.
July 12, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28698727/differences-in-mean-platelet-volume-and-platelet-count-between-children-with-simple-and-complex-febrile-seizures
#19
Ali Nikkhah, Mohammad Reza Salehiomran, Seyedeh Samane Asefi
OBJECTIVE: The aim of our study was to find the relationship of MPV (Mean Platelet Volume) levels and platelet counts as markers of inflammation between simple and complex febrile seizures. MATERIALS & METHODS: In this retrospective comparative study, we investigated the recordings of 356 children between 5 months and 6 yr with diagnosis of simple and complex febrile seizure (SFS&CFS) in Amircola's Children's Hospital, Babol University of Medical Sciences, Babol, Iran between Mar 2011 and Dec 2015...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28698680/activated-monocytes-enhance-platelet-driven-contraction-of-blood-clots-via-tissue-factor-expression
#20
Alina D Peshkova, Giang Le Minh, Valerie Tutwiler, Izabella A Andrianova, John W Weisel, Rustem I Litvinov
Platelet-driven reduction in blood clot volume (clot contraction or retraction) has been implicated to play a role in hemostasis and thrombosis. Although these processes are often linked with inflammation, the role of inflammatory cells in contraction of blood clots and thrombi has not been investigated. The aim of this work was to study the influence of activated monocytes on clot contraction. The effects of monocytes were evaluated using a quantitative optical tracking methodology to follow volume changes in a blood clot formed in vitro...
July 11, 2017: Scientific Reports
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