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Autoimmune syndrome adjuvants

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https://www.readbyqxmd.com/read/28526581/a-novel-mouse-model-of-chronic-prostatitis-chronic-pelvic-pain-syndrome-induced-by-immunization-of-special-peptide-fragment-with-aluminum-hydroxide-adjuvant
#1
Farhan Ullah Khan, Awais Ullah Ihsan, Waqas Nawaz, Muhammad Zahid Khan, Mengqi Yang, Gang Wang, Xiaoqian Liao, Lei Han, Xiaohui Zhou
OBJECTIVES: CP/CPPS is a commonly observed distress in male patients. Because of its little-known etiology, no effective therapy has been developed which has promising outcomes. Therefore, there is a need to develop a valid model which can mimic the etiology of CP/CPPS. MATERIALS AND METHODS: Fifty male C57BL/6 mice were randomly and averagely divided into 5 groups of 10 mice each. The control group was injected with 0.9% NaCl solution. Aluminum hydroxide and T2 groups were injected with aluminum hydroxide adjuvant and T2 peptide...
May 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28466365/women-with-silicone-breast-implants-and-autoimmune-inflammatory-syndrome-induced-by-adjuvants-description-of-three-patients-and-a-critical-review-of-the-literature
#2
REVIEW
Slavica Pavlov-Dolijanovic, Nada Vujasinovic Stupar
Silicone has been widely used in the manufacture of medical implants. It is well tolerated in most cases. However, in this paper we report the cases of three women who developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), namely with silicone breast implants. The symptoms in these cases include arthralgia, arthritis, myalgia, sleep disturbances, the appearance of autoantibodies, miscarriage, Raynaud's phenomenon, and involvement of autoimmune diseases (scleroderma and undifferentiated connective tissue diseases)...
May 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28440992/-autoimmune-inflammatory-syndrome-induced-by-adjuvants-a-new-clinical-entity
#3
Belkis Ferrer-Cosme, Damiana Téllez-Martínez, Alexander Batista-Duharte
Recently Shoenfeld and Agmon-Levin proposed a new clinical entity called autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which includes four clinical entities called: 1) siliconosis, 2) Gulf War syndrome, 3) macrophage myofasciitis) and 4) post-vaccination phenomenon associated with adjuvants. They all have a common denominator: a prior exposure to immunoadjuvants, and, in addition, they also share several clinical criteria associated to chronic inflammation and autoimmune reactions. This proposal still needs to be validated by the scientific community, but nowadays is a topic of hot discussion in the literature and in various international conferences...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28379860/silicone-breast-implants-and-autoimmune-rheumatic-diseases-myth-or-reality
#4
Jan Willem Cohen Tervaert, Maartje J Colaris, René R van der Hulst
PURPOSE OF REVIEW: In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. RECENT FINDINGS: Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may 'bleed' and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and can be detected in tissues and the central nervous system...
July 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28368979/undifferentiated-connective-tissue-disease-fibromyalgia-and-the-environmental-factors
#5
Laura Andreoli, Angela Tincani
PURPOSE OF REVIEW: The aim of this study was to discuss the role of environmental factors in the induction and perpetuation of autoimmunity, with particular focus on undifferentiated connective tissue disease (UCTD) and fibromyalgia. These two entities may share undefined clinical and laboratory features and recognize environmental exposures as triggering factors. From this particular point of view, both UCTD and fibromyalgia may resemble the picture of the 'Autoimmune/Inflammatory Syndrome Induced by Adjuvants' (ASIA)...
July 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28332072/are-the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-and-the-undifferentiated-connective-tissue-disease-uctd-related-to-each-other-a-case-control-study-of-environmental-exposures
#6
F Scanzi, L Andreoli, M Martinelli, M Taraborelli, I Cavazzana, N Carabellese, R Ottaviani, F Allegri, F Franceschini, N Agmon-Levin, Y Shoenfeld, Angela Tincani
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an exposure to adjuvants can be a trigger also for UCTD. The aim of this case-control study was to investigate exposure to adjuvants prior to disease onset in patients affected by UCTD. Ninety-two UCTD patients and 92 age- and sex-matched controls with no malignancy, chronic infections, autoimmune disease nor family history of autoimmune diseases were investigated for exposure to adjuvants...
March 22, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28303359/vitamin-d-deficiency-as-a-risk-factor-for-the-development-of-autoantibodies-in-patients-with-asia-and-silicone-breast-implants-a-cohort-study-and-review-of-the-literature
#7
Maartje J L Colaris, Rene R van der Hulst, Jan Willem Cohen Tervaert
The development of autoimmunity and/or autoimmune diseases is multifactorial. Vitamin D is one of the factors that might play a role. We postulated that both the presence of adjuvants and insufficient levels of vitamin D may result in the development of autoimmunity in patients with autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in relation to silicone implant incompatibility. We measured vitamin D levels in 135 patients with ASIA in relation to silicone implant incompatibility and related findings to the presence of autoantibodies that are commonly used to diagnose systemic autoimmune diseases...
May 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28260057/inhibition-of-triggering-receptor-expressed-on-myeloid-cells-1-ameliorates-experimental-autoimmune-neuritis
#8
Xiaoliang Zhou, Yanli Wang, Yuzhong Wang, Peter Cipriano, Bo Xiao, Wenbin Zhou
Experimental autoimmune neuritis (EAN) is a cluster of differentiation 4+ T helper 1 cell-mediated inflammatory demyelinating disease of the peripheral nervous system and serves as a useful animal model for Guillain‑Barré syndrome. Triggering receptor expressed on myeloid cells‑1 (TREM‑1) is an important receptor involved in sepsis and the innate inflammatory response. Linear plasmid 17 (LP 17) peptide is a competitive antagonist of TREM‑1. To investigate the role of TREM‑1 in EAN, 64 male Lewis rats were randomly divided into four groups: Normal saline, complete Freund's adjuvant, EAN and LP 17...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28204878/unusual-onset-of-adult-still-s-disease-due-to-a%C3%A2-systemic-reaction-to-artificial-breast-implants
#9
A Wehr, G Grieb, C Trautwein, K Streetz
In this manuscript, we report an exceptional observation study of a young woman suffering from an autoimmune syndrome induced by adjuvants (ASIA). Until today only seven cases of adult-onset Still's disease (AOSD) induced by breast implants have been published. This may be due to the fact that this illness itself is very rare; however, the reason might also be that the community is not sensitized to the case-specific symptoms. Within this article, we show for the first time highly detailed diagnostic test procedures such as PET-CT scans and specific histological staining of the breast tissue, displaying proinflammatory macrophages that are a well-known activator and booster of autoimmune diseases...
February 15, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28059022/autoimmune-inflammatory-syndrome-induced-by-adjuvants-shoenfeld-s-syndrome-an-update
#10
A Watad, M Quaresma, S Brown, J W Cohen Tervaert, I Rodríguez-Pint, R Cervera, C Perricone, Y Shoenfeld
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) has been widely described in many studies conducted thus far. The syndrome incorporates five immune-mediated conditions, all associated with previous exposure to various agents such as vaccines, silicone implants and several others. The emergence of ASIA syndrome is associated with individual genetic predisposition, for instance those carrying HLA-DRB1*01 or HLA-DRB4 and results from exposure to external or endogenous factors triggering autoimmunity...
June 2017: Lupus
https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#11
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
January 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27699823/chronic-pelvic-pain-development-and-prostate-inflammation-in-strains-of-mice-with-different-susceptibility-to-experimental-autoimmune-prostatitis
#12
Maria L Breser, Ruben D Motrich, Leonardo R Sanchez, Virginia E Rivero
BACKGROUND: Experimental autoimmune prostatitis (EAP) is an autoimmune inflammatory disease of the prostate characterized by peripheral prostate-specific autoimmune responses associated with prostate inflammation. EAP is induced in rodents upon immunization with prostate antigens (PAg) plus adjuvants and shares important clinical and immunological features with the human disease chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS: EAP was induced in young NOD, C57BL/6, and BALB/c male mice by immunization with PAg plus complete Freund́s adjuvant...
January 2017: Prostate
https://www.readbyqxmd.com/read/27665458/asia-syndrome-calcinosis-cutis-and-chronic-kidney-disease-following-silicone-injections-a-case-based-review
#13
REVIEW
Giuseppe Barilaro, Claudia Spaziani Testa, Antonella Cacciani, Giuseppe Donato, Mira Dimko, Amalia Mariotti
An immunologic adjuvant is a substance that enhances the antigen-specific immune response preferably without triggering one on its own. Silicone, a synthetic polymer used for reconstructive and cosmetic purposes, can cause, once injected, local and/or systemic reactions and trigger manifestations of autoimmunity, occasionally leading to an overt autoimmune disease. Siliconosis, calcinosis cutis with hypercalcemia and chronic kidney disease have all been reported in association with silicone injection. Here, we describe a case of autoimmune/auto-inflammatory syndrome induced by adjuvants, calcinosis cutis and chronic kidney disease after liquid silicone multiple injections in a young man who underwent a sex reassignment surgery, followed by a review of the literature...
December 2016: Immunologic Research
https://www.readbyqxmd.com/read/27643438/foxp3-tregs-require-wasp-to-restrain-th2-mediated-food-allergy
#14
Willem S Lexmond, Jeremy A Goettel, Jonathan J Lyons, Justin Jacobse, Marion M Deken, Monica G Lawrence, Thomas H DiMaggio, Daniel Kotlarz, Elizabeth Garabedian, Paul Sackstein, Celeste C Nelson, Nina Jones, Kelly D Stone, Fabio Candotti, Edmond H H M Rings, Adrian J Thrasher, Joshua D Milner, Scott B Snapper, Edda Fiebiger
In addition to the infectious consequences of immunodeficiency, patients with Wiskott-Aldrich syndrome (WAS) often suffer from poorly understood exaggerated immune responses that result in autoimmunity and elevated levels of serum IgE. Here, we have shown that WAS patients and mice deficient in WAS protein (WASP) frequently develop IgE-mediated reactions to common food allergens. WASP-deficient animals displayed an adjuvant-free IgE-sensitization to chow antigens that was most pronounced for wheat and soy and occurred under specific pathogen-free as well as germ-free housing conditions...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27634631/intravascular-large-b-cell-lymphoma-associated-with-silicone-breast-implant-hla-drb1-11-01-and-hla-dqb1-03-01-manifesting-as-macrophage-activation-syndrome-and-with-severe-neurological-symptoms-a-case-report
#15
Oswald Moling, Andrea Piccin, Martina Tauber, Peter Marinello, Mariagrazia Canova, Marco Casini, Giovanni Negri, Bernd Raffeiner, Raffaella Binazzi, Latha Gandini, Cinzia Vecchiato, Giovanni Rimenti, Atto Billio
BACKGROUND: Silicone implants have been successfully used for breast augmentation and reconstruction in millions of women worldwide. The reaction to the silicone implant is highly variable; it can lead to local inflammatory symptoms, and sometimes to systemic symptoms and disease. Over 80 cases of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma have been reported in patients with silicone breast implants and have been accepted as a new clinical entity. To the best of our knowledge, an intravascular large B-cell lymphoma associated with a silicone breast implant has not been reported previously...
September 15, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27592233/involvement-of-chronic-epipharyngitis-in-autoimmune-auto-inflammatory-syndrome-induced-by-adjuvants-asia
#16
Osamu Hotta, Ayaki Tanaka, Akira Torigoe, Kazuaki Imai, Norio Ieiri
The epipharynx is an immunologically active site even under normal conditions, and enhanced immunologic activation is prone to occur in response to an upper respiratory infection, air pollution, and possibly to vaccine adjuvants. Due to the potential link between the central nervous system and immune function, a relationship between epipharyngitis and autonomic nervous disturbance as well as autoimmune disease has been suggested. Various functional somatic symptoms have been described after human papillomavirus (HPV) vaccination, although a causal relationship has not been established...
September 3, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27536984/immune-reconstitution-inflammatory-syndrome-in-an-hiv-infected-patient-using-subcutaneous-silicone-fillers
#17
Hortensia Álvarez, Ana Mariño, José F García-Rodríguez, Alejandro Vilas-Sueiro, Nieves Valcarce, Josep M Llibre
The immune reconstitution inflammatory syndrome (IRIS) remains a concern in severely immunosuppressed HIV-infected patients after starting antiretroviral therapy. We present an HIV-infected transgender woman with subcutaneous silicone fillers, who simultaneously developed tuberculosis-associated and silicone-related IRIS. We propose a possible connection between IRIS and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27515982/rapidly-progressive-diffuse-systemic-sclerosis-after-local-vitamins-a-d-and-e-complex-injections-literature-review-and-report-of-two-cases
#18
Gustavo Guimarães Moreira Balbi, Ricardo Azêdo Montes, Verônica Silva Vilela, Marcella Azevedo Borges Andrade, Monisa Martins Nóbrega, Luna Azulay-Abulafia, Roberto Souto da Silva, Evandro Mendes Klumb, Roger Abramino Levy
The term autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) or Shoenfeld's syndrome refers to a wide group of immune-mediated diseases triggered by external agents. Several substances, such as vaccine adjuvants, squalene and silicone implants, are implied in the pathogenesis of ASIA syndrome. Treatment and prognosis of this complex condition are not completely known due to lack of good quality evidence. After a brief introductory literature review on ASIA, we report here two cases of patients that developed rapidly progressive systemic sclerosis clinical features after multiple intramuscular local injections of a substance recommended by a non-medical professional called ADE...
February 2017: Immunologic Research
https://www.readbyqxmd.com/read/27503625/severe-somatoform-and-dysautonomic-syndromes-after-hpv-vaccination-case-series-and-review-of-literature
#19
Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi
Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil(®) and Cervarix(®). Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our "Second Opinion Medical Network" for the evaluation of "neuropathy with autonomic dysfunction" after HPV vaccination...
February 2017: Immunologic Research
https://www.readbyqxmd.com/read/27449504/cross-reactivity-between-annexin-a2-and-beta-2-glycoprotein-i-in-animal-models-of-antiphospholipid-syndrome
#20
R Weiss, A Bitton, L Nahary, M T Arango, I Benhar, M Blank, Y Shoenfeld, J Chapman
Antiphospholipid syndrome (APS) affects coagulation and the brain by autoimmune mechanisms. The major antigen in APS is beta-2-glycoprotein I (β2-GPI) is known to complex with annexin A2 (ANXA2), and antibodies to ANXA2 have been described in APS. We measured these antibodies in mice with experimental APS (eAPS) induced by immunization with β2-GPI. Sera of these mice reacted significantly with recombinant ANXA2 by enzyme-linked immunosorbent assay (ELISA) and the eAPS mice had significantly high levels of immunoglobulin G (IgG) in the brain by immunoblot assays compared to adjuvant immunized controls...
July 23, 2016: Immunologic Research
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