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Autoimmune syndrome adjuvants

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https://www.readbyqxmd.com/read/29205874/establishment-of-experimental-autoimmune-prostatitis-model-by-t2-peptide-in-aluminium-hydroxide-adjuvant
#1
L Zhang, A U Ihsan, Y Cao, Y Cheng, X Zhou
A mouse model was developed to simulate the clinical features of chronic prostatitis/chronic pelvic pain syndrome using peptide (T2 ). Forty C57BL/6 mice were divided into four groups of 10 mice each, averagely and randomly. T2 plus aluminium hydroxide adjuvant group was given subcutaneous injection with the emulsion mixture of T2 and aluminium hydroxide adjuvant, the T2 group with T2 , the aluminium hydroxide adjuvant group with aluminium hydroxide adjuvant and the normal control group with 0.9/% NaCl solution...
December 4, 2017: Andrologia
https://www.readbyqxmd.com/read/29199390/autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-related-to-biomaterials-analysis-of-45-cases-and-comprehensive-review-of-the-literature
#2
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Natalia Gil-Aliberas, Victor Garcia-Gimenez
Systemic autoimmune or granulomatous disorders related to biomaterials of human use have rarely been described. The aim of this study was to report cases of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) related to biomaterial injections and prostheses, mainly silicone, hyaluronic acid, acrylamides and methacrylate compounds in a Spanish patient cohort. This study is a retrospective analysis of clinical, laboratory, histopathological and follow-up data of 45 cases of patients suffering from late-onset, non-infectious inflammatory/autoimmune disorders related to bioimplants...
December 3, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29172967/a-comprehensive-analysis-of-italian-web-pages-mentioning-squalene-based-influenza-vaccine-adjuvants-reveals-a-high-prevalence-of-misinformation
#3
Donatella Panatto, Daniela Amicizia, Lucia Arata, Piero Luigi Lai, Roberto Gasparini
Squalene-based adjuvants have been included in influenza vaccines since 1997. Despite several advantages of adjuvanted seasonal and pandemic influenza vaccines, laypeople's perception of such formulations may be hesitant or even negative under certain circumstances. Moreover, in Italian, the term "squalene" has the same root as such common words as "shark" (squalo), "squalid" and "squalidness" that tend to have negative connotations. This study aimed to quantitatively and qualitatively analyze a representative sample of Italian web pages mentioning squalene-based adjuvants used in influenza vaccines...
November 27, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29099692/macrophage-activation-syndrome-associated-with-systemic-lupus-erythematosus-treated-successfully-with-the-combination-of-steroid-pulse-immunoglobulin-and-tacrolimus
#4
Natsuki Aoyama-Maeda, Taro Horino, Osamu Ichii, Yoshio Terada
Macrophage activation syndrome (MAS), a variant of secondary hemophagocytic lymphohistiocytosis, is a potentially life-threatening complication of inflammatory and autoimmune diseases. We present a case of MAS as a rare manifestation of systemic lupus erythematosus. Although initial treatment with corticosteroid, with or without cyclosporine A, is justified in patients with MAS, evidence regarding the effectiveness of this treatment protocol remains to be clarified. Our patient was successfully treated with a combination of intravenous immunoglobulin therapy and intravenous methyl predonisolone pulse therapy, which was followed by a course of oral prednisolone and oral tacrolimus...
November 1, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29062654/autoimmune-syndrome-induced-by-adjuvants-asia-after-silicone-breast-augmentation-surgery
#5
Daniel Nunes E Silva, Cíntia Gründler, Maria das Graças de Melo Teixeira Spengler, Alex Magno Coelho Horimoto, Mariana Albuquerque Machado, Isadora Carvalho Frazão, Luiz Carlos Takita
Generally, the main complications of silicone implantation are local symptoms. However, some patients develop late-onset systemic symptoms often associated with a rare form of hyperactive immune response, as part of a syndrome known as autoimmune syndrome induced by adjuvants (ASIA). Reported cases of ASIA have shown resolution with explantation, but not with immunomodulatory therapy. In this report, we described a case of a previously healthy 23-year-old woman, who has undergone silicone breast implant augmentation, for aesthetic reasons, and developed localized cutaneous impairment 3 years postsurgery...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29044021/-asia-syndrome-breast-implant-and-still-s-disease
#6
Cristhian Armenteros, Andrea Odzak, Florencia Arcondo, Marcela De Dios Soler, Tatiana Sinigier, Marcelo Zylberman
Connective tissue diseases associated with silicone breast implants have been widely discussed. In the last decade, siliconosis has been included in the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) next to Gulf War syndrome, macrophage myofascitis and postvaccination phenomena. The ASIA syndrome may appear as lupus, rheumatoid arthritis, or more rarely, as adult Still's disease. We discuss the case of a patient with prolonged fever and clinical criteria for ASIA and Still's disease. The prostheses were resected and pathology showed absence of breast implant associated anaplastic lymphoma ALK (-)...
2017: Medicina
https://www.readbyqxmd.com/read/28966480/the-memory-lymphocyte-immunostimulation-assay-in-immune-system-disorders-is-useful-or-useless
#7
Maria Vadalà, Carmen Laurino, Beniamino Palmieri
AIM: The aim of the study was to evaluate the clinical relevance, sensitivity and specificity of in vitro blood test, Memory Lymphocyte ImmunoStimulation Assay (MELISA(®)), in genetically predisposed patients that suffer by autoimmune/inflammatory syndrome induced by adjuvants, after HPV-vaccination and that could have a high metal hypersensitivity. MATERIALS AND METHODS: Sixteen girls (aged 12-24 years) that developed long-lasting and invalidating somatoform symptoms occurring within 20 days postvaccination are included in this descriptive study...
October 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28888842/evidence-refuting-the-existence-of-autoimmune-autoinflammatory-syndrome-induced%C3%A2-by-adjuvants-asia
#8
Rohan Ameratunga, David Gillis, Michael Gold, Allan Linneberg, J Mark Elwood
Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was described in 2011. Over time the condition and its triggers have broadened to include several autoimmune disorders, the macrophagic myofasciitis syndrome, the Gulf war syndrome, the sick building syndrome, siliconosis, and the chronic fatigue syndrome. The aluminum-containing adjuvants in the hepatitis B vaccine and the human papillomavirus vaccine in particular have been stated to be the major causes of the disorder. Here, we review the specificity of the diagnostic criteria for ASIA...
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28821265/poncet-s-disease-after-the-intravesical-instillation-of-bacillus-calmette-gu%C3%A3-rin-bcg-a-case-report
#9
Paula Cíntia Machado Sampaio, Yan Garcia Lira, Hellen Yuki Umemura Ribeiro, Fernanda de Paula Moreira, Maitê Silva Martins Gadelha, Sérgio Ferreira Santos da Cruz
BACKGROUND: Poncet's disease is a rare syndrome characterized by articular impairment in a form of rare tuberculid. One of the theories of its cause involves an autoimmune response induced by the intravesical administration of the Calmette-Guerin Bacillus or the treatment of bladder carcinoma. Furthermore, there may be an appearance of oligoarticular or polyarticular arthritis, beginning 1-3 months after the start of therapy. Few physicians know the disease and the literature related to that syndrome is scarce and restricted to case reports, which contributes to its under diagnosis...
August 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28811706/therapeutic-potential-of-flavonoids-in-inflammatory-bowel-disease-a-comprehensive-review
#10
REVIEW
Ali Salaritabar, Behrad Darvishi, Farzaneh Hadjiakhoondi, Azadeh Manayi, Antoni Sureda, Seyed Fazel Nabavi, Leo R Fitzpatrick, Seyed Mohammad Nabavi, Anupam Bishayee
The inflammatory process plays a central role in the development and progression of numerous pathological situations, such as inflammatory bowel disease (IBD), autoimmune and neurodegenerative diseases, metabolic syndrome, and cardiovascular disorders. IBDs involve inflammation of the gastrointestinal area and mainly comprise Crohn's disease (CD) and ulcerative colitis (UC). Both pathological situations usually involve recurring or bloody diarrhea, pain, fatigue and weight loss. There is at present no pharmacological cure for CD or UC...
July 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28741088/the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-shoenfeld-s-syndrome-descriptive-analysis-of-300-patients-from-the-international-asia-syndrome-registry
#11
Abdulla Watad, Mariana Quaresma, Nicola Luigi Bragazzi, Ricard Cervera, Jan Willem Cohen Tervaert, Howard Amital, Yehuda Shoenfeld
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is a recently identified condition in which the exposure to an adjuvant leads to an aberrant autoimmune response. We aimed to summarize the results obtained from the ASIA syndrome registry up to December 2016, in a descriptive analysis of 300 cases of ASIA syndrome, with a focus on the adjuvants, the clinical manifestations, and the relationship with other autoimmune diseases. A Web-based registry, based on a multicenter international study, collected clinical and laboratory data in a form of a questionnaire applied to patients with ASIA syndrome...
July 25, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28739610/silicone-implant-incompatibility-syndrome-siis-in-a-57-year-old-woman-with-unilateral-silicone-breast-implant
#12
Juliane Schierbeck, Jesper Rømhild Davidsen, Sanne Grindsted Nielsen, Camilla Bille
Since the 1960s, silicone implants have been used for breast augmentations, both cosmetically and in reconstructive surgery. Tissue exposed to silicone can react with multiple adverse advents. Autoimmune/inflammatory syndrome induced by adjuvants due to silicone exposure from ruptured silicone implants can lead to different interstitial lung manifestations predominantly with granuloma evolvement, leading to the so-called silicone implant incompatibility syndrome (SIIS). This case describes a 57-year-old woman with multiple lung infiltrations and a left-sided breast implant...
July 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28526581/a-novel-mouse-model-of-chronic-prostatitis-chronic-pelvic-pain-syndrome-induced-by-immunization-of-special-peptide-fragment-with-aluminum-hydroxide-adjuvant
#13
Farhan Ullah Khan, Awais Ullah Ihsan, Waqas Nawaz, Muhammad Zahid Khan, Mengqi Yang, Gang Wang, Xiaoqian Liao, Lei Han, Xiaohui Zhou
OBJECTIVES: CP/CPPS is a commonly observed distress in male patients. Because of its little-known etiology, no effective therapy has been developed which has promising outcomes. Therefore, there is a need to develop a valid model which can mimic the etiology of CP/CPPS. MATERIALS AND METHODS: Fifty male C57BL/6 mice were randomly and averagely divided into 5 groups of 10 mice each. The control group was injected with 0.9% NaCl solution. Aluminum hydroxide and T2 groups were injected with aluminum hydroxide adjuvant and T2 peptide...
May 16, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28466365/women-with-silicone-breast-implants-and-autoimmune-inflammatory-syndrome-induced-by-adjuvants-description-of-three-patients-and-a-critical-review-of-the-literature
#14
REVIEW
Slavica Pavlov-Dolijanovic, Nada Vujasinovic Stupar
Silicone has been widely used in the manufacture of medical implants. It is well tolerated in most cases. However, in this paper we report the cases of three women who developed autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome), namely with silicone breast implants. The symptoms in these cases include arthralgia, arthritis, myalgia, sleep disturbances, the appearance of autoantibodies, miscarriage, Raynaud's phenomenon, and involvement of autoimmune diseases (scleroderma and undifferentiated connective tissue diseases)...
August 2017: Rheumatology International
https://www.readbyqxmd.com/read/28440992/-autoimmune-inflammatory-syndrome-induced-by-adjuvants-a-new-clinical-entity
#15
Belkis Ferrer-Cosme, Damiana Téllez-Martínez, Alexander Batista-Duharte
Recently Shoenfeld and Agmon-Levin proposed a new clinical entity called autoimmune/inflammatory syndrome induced by adjuvants (ASIA), which includes four clinical entities called: 1) siliconosis, 2) Gulf War syndrome, 3) macrophage myofasciitis) and 4) post-vaccination phenomenon associated with adjuvants. They all have a common denominator: a prior exposure to immunoadjuvants, and, in addition, they also share several clinical criteria associated to chronic inflammation and autoimmune reactions. This proposal still needs to be validated by the scientific community, but nowadays is a topic of hot discussion in the literature and in various international conferences...
May 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28379860/silicone-breast-implants-and-autoimmune-rheumatic-diseases-myth-or-reality
#16
Jan Willem Cohen Tervaert, Maartje J Colaris, René R van der Hulst
PURPOSE OF REVIEW: In the present review, recent findings regarding silicone breast implants (SBIs) complicated by rheumatic autoimmune diseases are described. RECENT FINDINGS: Despite changes in the principal constituents of the silicone implants during the past 50 years, silicone remained an adjuvant that may 'bleed' and subsequently may be a chronic stimulus to the immune system resulting in similar clinical manifestations as 50 years ago. Silicones are spread throughout the body and can be detected in tissues and the central nervous system...
July 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28368979/undifferentiated-connective-tissue-disease-fibromyalgia-and-the-environmental-factors
#17
Laura Andreoli, Angela Tincani
PURPOSE OF REVIEW: The aim of this study was to discuss the role of environmental factors in the induction and perpetuation of autoimmunity, with particular focus on undifferentiated connective tissue disease (UCTD) and fibromyalgia. These two entities may share undefined clinical and laboratory features and recognize environmental exposures as triggering factors. From this particular point of view, both UCTD and fibromyalgia may resemble the picture of the 'Autoimmune/Inflammatory Syndrome Induced by Adjuvants' (ASIA)...
July 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28332072/are-the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-and-the-undifferentiated-connective-tissue-disease-uctd-related-to-each-other-a-case-control-study-of-environmental-exposures
#18
F Scanzi, L Andreoli, M Martinelli, M Taraborelli, I Cavazzana, N Carabellese, R Ottaviani, F Allegri, F Franceschini, N Agmon-Levin, Y Shoenfeld, Angela Tincani
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an exposure to adjuvants can be a trigger also for UCTD. The aim of this case-control study was to investigate exposure to adjuvants prior to disease onset in patients affected by UCTD. Ninety-two UCTD patients and 92 age- and sex-matched controls with no malignancy, chronic infections, autoimmune disease nor family history of autoimmune diseases were investigated for exposure to adjuvants...
February 2017: Immunologic Research
https://www.readbyqxmd.com/read/28303359/vitamin-d-deficiency-as-a-risk-factor-for-the-development-of-autoantibodies-in-patients-with-asia-and-silicone-breast-implants-a-cohort-study-and-review-of-the-literature
#19
Maartje J L Colaris, Rene R van der Hulst, Jan Willem Cohen Tervaert
The development of autoimmunity and/or autoimmune diseases is multifactorial. Vitamin D is one of the factors that might play a role. We postulated that both the presence of adjuvants and insufficient levels of vitamin D may result in the development of autoimmunity in patients with autoimmune/inflammatory syndrome induced by adjuvants (ASIA) in relation to silicone implant incompatibility. We measured vitamin D levels in 135 patients with ASIA in relation to silicone implant incompatibility and related findings to the presence of autoantibodies that are commonly used to diagnose systemic autoimmune diseases...
May 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28260057/inhibition-of-triggering-receptor-expressed-on-myeloid-cells-1-ameliorates-experimental-autoimmune-neuritis
#20
Xiaoliang Zhou, Yanli Wang, Yuzhong Wang, Peter Cipriano, Bo Xiao, Wenbin Zhou
Experimental autoimmune neuritis (EAN) is a cluster of differentiation 4+ T helper 1 cell-mediated inflammatory demyelinating disease of the peripheral nervous system and serves as a useful animal model for Guillain‑Barré syndrome. Triggering receptor expressed on myeloid cells‑1 (TREM‑1) is an important receptor involved in sepsis and the innate inflammatory response. Linear plasmid 17 (LP 17) peptide is a competitive antagonist of TREM‑1. To investigate the role of TREM‑1 in EAN, 64 male Lewis rats were randomly divided into four groups: Normal saline, complete Freund's adjuvant, EAN and LP 17...
April 2017: Molecular Medicine Reports
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