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Autoimmune syndrome adjuvants

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https://www.readbyqxmd.com/read/27908630/non-linear-dose-response-of-aluminium-hydroxide-adjuvant-particles-selective-low-dose-neurotoxicity
#1
Guillemette Crépeaux, Housam Eidi, Marie-Odile David, Yasmine Baba-Amer, Eleni Tzavara, Bruno Giros, François-Jérôme Authier, Christopher Exley, Christopher A Shaw, Josette Cadusseau, Romain K Gherardi
Aluminium (Al) oxyhydroxide (Alhydrogel(®)), the main adjuvant licensed for human and animal vaccines, consists of primary nanoparticles that spontaneously agglomerate. Concerns about its safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and reports of chronic fatigue syndrome, cognitive dysfunction, myalgia, dysautonomia and autoimmune/inflammatory features temporally linked to multiple Al-containing vaccine administrations. Mouse experiments have documented its capture and slow transportation by monocyte-lineage cells from the injected muscle to lymphoid organs and eventually the brain...
November 28, 2016: Toxicology
https://www.readbyqxmd.com/read/27699823/chronic-pelvic-pain-development-and-prostate-inflammation-in-strains-of-mice-with-different-susceptibility-to-experimental-autoimmune-prostatitis
#2
Maria L Breser, Ruben D Motrich, Leonardo R Sanchez, Virginia E Rivero
BACKGROUND: Experimental autoimmune prostatitis (EAP) is an autoimmune inflammatory disease of the prostate characterized by peripheral prostate-specific autoimmune responses associated with prostate inflammation. EAP is induced in rodents upon immunization with prostate antigens (PAg) plus adjuvants and shares important clinical and immunological features with the human disease chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). METHODS: EAP was induced in young NOD, C57BL/6, and BALB/c male mice by immunization with PAg plus complete Freund́s adjuvant...
October 4, 2016: Prostate
https://www.readbyqxmd.com/read/27665458/asia-syndrome-calcinosis-cutis-and-chronic-kidney-disease-following-silicone-injections-a-case-based-review
#3
Giuseppe Barilaro, Claudia Spaziani Testa, Antonella Cacciani, Giuseppe Donato, Mira Dimko, Amalia Mariotti
An immunologic adjuvant is a substance that enhances the antigen-specific immune response preferably without triggering one on its own. Silicone, a synthetic polymer used for reconstructive and cosmetic purposes, can cause, once injected, local and/or systemic reactions and trigger manifestations of autoimmunity, occasionally leading to an overt autoimmune disease. Siliconosis, calcinosis cutis with hypercalcemia and chronic kidney disease have all been reported in association with silicone injection. Here, we describe a case of autoimmune/auto-inflammatory syndrome induced by adjuvants, calcinosis cutis and chronic kidney disease after liquid silicone multiple injections in a young man who underwent a sex reassignment surgery, followed by a review of the literature...
September 24, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27643438/foxp3-tregs-require-wasp-to-restrain-th2-mediated-food-allergy
#4
Willem S Lexmond, Jeremy A Goettel, Jonathan J Lyons, Justin Jacobse, Marion M Deken, Monica G Lawrence, Thomas H DiMaggio, Daniel Kotlarz, Elizabeth Garabedian, Paul Sackstein, Celeste C Nelson, Nina Jones, Kelly D Stone, Fabio Candotti, Edmond H H M Rings, Adrian J Thrasher, Joshua D Milner, Scott B Snapper, Edda Fiebiger
In addition to the infectious consequences of immunodeficiency, patients with Wiskott-Aldrich syndrome (WAS) often suffer from poorly understood exaggerated immune responses that result in autoimmunity and elevated levels of serum IgE. Here, we have shown that WAS patients and mice deficient in WAS protein (WASP) frequently develop IgE-mediated reactions to common food allergens. WASP-deficient animals displayed an adjuvant-free IgE-sensitization to chow antigens that was most pronounced for wheat and soy and occurred under specific pathogen-free as well as germ-free housing conditions...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27634631/intravascular-large-b-cell-lymphoma-associated-with-silicone-breast-implant-hla-drb1-11-01-and-hla-dqb1-03-01-manifesting-as-macrophage-activation-syndrome-and-with-severe-neurological-symptoms-a-case-report
#5
Oswald Moling, Andrea Piccin, Martina Tauber, Peter Marinello, Mariagrazia Canova, Marco Casini, Giovanni Negri, Bernd Raffeiner, Raffaella Binazzi, Latha Gandini, Cinzia Vecchiato, Giovanni Rimenti, Atto Billio
BACKGROUND: Silicone implants have been successfully used for breast augmentation and reconstruction in millions of women worldwide. The reaction to the silicone implant is highly variable; it can lead to local inflammatory symptoms, and sometimes to systemic symptoms and disease. Over 80 cases of anaplastic lymphoma kinase-negative anaplastic large cell lymphoma have been reported in patients with silicone breast implants and have been accepted as a new clinical entity. To the best of our knowledge, an intravascular large B-cell lymphoma associated with a silicone breast implant has not been reported previously...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27592233/involvement-of-chronic-epipharyngitis-in-autoimmune-auto-inflammatory-syndrome-induced-by-adjuvants-asia
#6
Osamu Hotta, Ayaki Tanaka, Akira Torigoe, Kazuaki Imai, Norio Ieiri
The epipharynx is an immunologically active site even under normal conditions, and enhanced immunologic activation is prone to occur in response to an upper respiratory infection, air pollution, and possibly to vaccine adjuvants. Due to the potential link between the central nervous system and immune function, a relationship between epipharyngitis and autonomic nervous disturbance as well as autoimmune disease has been suggested. Various functional somatic symptoms have been described after human papillomavirus (HPV) vaccination, although a causal relationship has not been established...
September 3, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27536984/immune-reconstitution-inflammatory-syndrome-in-an-hiv-infected-patient-using-subcutaneous-silicone-fillers
#7
Hortensia Álvarez, Ana Mariño, José F García-Rodríguez, Alejandro Vilas-Sueiro, Nieves Valcarce, Josep M Llibre
The immune reconstitution inflammatory syndrome (IRIS) remains a concern in severely immunosuppressed HIV-infected patients after starting antiretroviral therapy. We present an HIV-infected transgender woman with subcutaneous silicone fillers, who simultaneously developed tuberculosis-associated and silicone-related IRIS. We propose a possible connection between IRIS and the autoimmune/inflammatory syndrome induced by adjuvants (ASIA).
October 23, 2016: AIDS
https://www.readbyqxmd.com/read/27515982/rapidly-progressive-diffuse-systemic-sclerosis-after-local-vitamins-a-d-and-e-complex-injections-literature-review-and-report-of-two-cases
#8
Gustavo Guimarães Moreira Balbi, Ricardo Azêdo Montes, Verônica Silva Vilela, Marcella Azevedo Borges Andrade, Monisa Martins Nóbrega, Luna Azulay-Abulafia, Roberto Souto da Silva, Evandro Mendes Klumb, Roger Abramino Levy
The term autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) or Shoenfeld's syndrome refers to a wide group of immune-mediated diseases triggered by external agents. Several substances, such as vaccine adjuvants, squalene and silicone implants, are implied in the pathogenesis of ASIA syndrome. Treatment and prognosis of this complex condition are not completely known due to lack of good quality evidence. After a brief introductory literature review on ASIA, we report here two cases of patients that developed rapidly progressive systemic sclerosis clinical features after multiple intramuscular local injections of a substance recommended by a non-medical professional called ADE...
August 11, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27503625/severe-somatoform-and-dysautonomic-syndromes-after-hpv-vaccination-case-series-and-review-of-literature
#9
Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, Emilio Clementi
Human papilloma virus (HPV) is recognized as a major cause for cervical cancer among women worldwide. Two HPV vaccines are currently available: Gardasil(®) and Cervarix(®). Both vaccines enclose viral antigenic proteins, but differ as to the biological systems of culture and the adjuvant components. Recently, a collection of symptoms, indicating nervous system dysfunction, has been described after HPV vaccination. We retrospectively described a case series including 18 girls (aged 12-24 years) referred to our "Second Opinion Medical Network" for the evaluation of "neuropathy with autonomic dysfunction" after HPV vaccination...
August 9, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27449504/cross-reactivity-between-annexin-a2-and-beta-2-glycoprotein-i-in-animal-models-of-antiphospholipid-syndrome
#10
R Weiss, A Bitton, L Nahary, M T Arango, I Benhar, M Blank, Y Shoenfeld, J Chapman
Antiphospholipid syndrome (APS) affects coagulation and the brain by autoimmune mechanisms. The major antigen in APS is beta-2-glycoprotein I (β2-GPI) is known to complex with annexin A2 (ANXA2), and antibodies to ANXA2 have been described in APS. We measured these antibodies in mice with experimental APS (eAPS) induced by immunization with β2-GPI. Sera of these mice reacted significantly with recombinant ANXA2 by enzyme-linked immunosorbent assay (ELISA) and the eAPS mice had significantly high levels of immunoglobulin G (IgG) in the brain by immunoblot assays compared to adjuvant immunized controls...
July 23, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27417999/adjuvants-and-vaccines-induced-autoimmunity-animal-models
#11
Jiram Torres Ruiz, Luis Luján, Miri Blank, Yehuda Shoenfeld
The emergence of autoimmunity after vaccination has been described in many case reports and series. Everyday there is more evidence that this relationship is more than casual. In humans, adjuvants can induce non-specific constitutional, musculoskeletal or neurological clinical manifestations and in certain cases can lead to the appearance or acceleration of an autoimmune disease in a subject with genetic susceptibility. The fact that vaccines and adjuvants can trigger a pathogenic autoimmune response is corroborated by animal models...
July 14, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27412294/severe-manifestations-of-autoimmune-syndrome-induced-by-adjuvants-shoenfeld-s-syndrome
#12
Luis J Jara, Grettel García-Collinot, Gabriela Medina, Maria Del Pilar Cruz-Dominguez, Olga Vera-Lastra, Rosa A Carranza-Muleiro, Miguel A Saavedra
Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) encompassing conditions linked to previous exposure to an adjuvant substance. The clinical picture is very heterogeneous, from mild to severe manifestations, including death. However, the systematic analysis of severe ASIA cases has not been performed. The aim of this study was to systematically review the literature on severe ASIA cases. A systematic review of the literature was performed investigating severe ASIA cases. All publications were identified through PubMed, EMBASE, MEDLINE and Cochrane...
July 13, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27406737/two-hundreds-cases-of-asia-syndrome-following-silicone-implants-a-comparative-study-of-30%C3%A2-years-and-a-review-of-current-literature
#13
Maartje J L Colaris, Mintsje de Boer, Rene R van der Hulst, Jan Willem Cohen Tervaert
In this study, we compared one hundred patients with autoimmune/inflammatory syndrome induced by adjuvants (ASIA) due to silicone implant incompatibility syndrome diagnosed in 2014 in Maastricht, the Netherlands, with one hundred historical patients with adjuvant breast disease diagnosed in the Baylor College of Medicine, Houston, USA, between 1985 and 1992. Similarities and differences between these two cohorts were identified to determine whether the spectrum of silicone-related disease changed during the last 30 years...
July 13, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27372915/annexin-a2-autoimmunity-anxiety-and-depression
#14
R Weiss, A Bitton, M Ben Shimon, S Elhaik Goldman, L Nahary, I Cooper, I Benhar, C G Pick, J Chapman
OBJECTIVES: Antiphospholipid syndrome (APS) is associated with neurological manifestations and one of the novel autoantigens associated with this disease is Annexin A2 (ANXA2). In this work we have examined the effect of high levels of autoantibodies to ANXA2 on the brain in a mouse model. METHODS: Recombinant ANXA2 emulsified in adjuvant was used to immunize mice while mice immunized with adjuvant only served as controls. At peak antibody levels the animal underwent behavioral and cognitive tests and their brains were examined for ANXA2 immunoglobulin G (IgG) and expression of ANXA2 and the closely linked protein p11...
September 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27279373/fhr3-blocks-c3d-mediated-coactivation-of-human-b-cells
#15
Denise Buhlmann, Hannes U Eberhardt, Anna Medyukhina, Wolfgang M Prodinger, Marc Thilo Figge, Peter F Zipfel, Christine Skerka
The autoimmune renal disease deficient for complement factor H-related (CFHR) genes and autoantibody-positive form of hemolytic uremic syndrome is characterized by the presence of autoantibodies specific for the central complement regulator, factor H, combined with a homozygous deficiency, mostly in CFHR3 and CFHR1 Because FHR3 and FHR1 bind to C3d and inactivated C3b, which are ligands for complement receptor type 2 (CR2/CD21), the aim of the current study was to examine whether FHR3-C3d or FHR1-C3d complexes modulate B cell activation...
July 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27269045/corrigendum-to-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-2013-unveiling-the-pathogenic-clinical-and-diagnostic-aspects-j-autoimmun-47c-2013-1-16
#16
Carlo Perricone, Serena Colafrancesco, Roei D Mazor, Alessandra Soriano, Nancy Agmon-Levin, Yehuda Shoenfeld
No abstract text is available yet for this article.
June 3, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27228631/autoimmune-inflammatory-syndrome-induced-by-adjuvants-and-sj%C3%A3-gren-s-syndrome
#17
Serena Colafrancesco, Carlo Perricone, Yehuda Shoenfeld
Sjögren's syndrome (SS), a chronic systemic autoimmune inflammatory condition involving the exocrine glands, has been suggested to be part of the spectrum of the Autoimmune/ inflammatory Syndrome Induced by Adjuvants (ASIA). ASIA incorporates an umbrella of clinical conditions including siliconosis, macrophage myofasciitis syndrome, and post-vaccination phenomena that occur after the exposure to a substance, namely the adjuvant. Interestingly, SS and ASIA share several common features. Firstly, a shared pathogenic mechanism involving a disruption of the immune system balance, with B cell proliferation, cytokine production and tissue infiltration, has been proposed...
March 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/26968919/salivary-proteomics-a-new-adjuvant-approach-to-the-early-diagnosis-of-familial-juvenile-systemic-lupus-erythematosus
#18
Aline Lauria P Abrão, Denise Pinheiro Falcao, Rivadávio Fernandes Batista de Amorim, Ana Cristina B Bezerra, Gilson Augusto N M Pombeiro, Luciano Junqueira Guimarães, Felipe Fregni, Luciano Paulino Silva, Licia Maria Henrique da Mota
Systemic lupus erythematosus (SLE) is a chronic multisystemic disease characterized by autoimmune inflammatory disturbance. Pleomorphic manifestations are present and a potentially progressive and debilitating course can be detected. SLE rarely manifests before age 5, and its onset peaks is around puberty. Although clinical manifestations, immunological alterations and treatment do not differ between juvenile and adult SLE, children tend to present with a more aggressive disease course than adults. Hence, autoimmune rheumatic diseases are the most common cause of morbidity and mortality in pediatric populations...
April 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/26877725/post-vaccination-myositis-and-myocarditis-in-a-previously-healthy-male
#19
Matthew P Cheng, Michael G Kozoriz, Amir A Ahmadi, John Kelsall, Katryn Paquette, Jake M Onrot
BACKGROUND: The immunological literature has been redefining clinical phenomena as hypotheses emerge regarding causal links between triggers, immunologic manifestations, and their specific inflammatory cascades. Of late, autoimmune manifestations that appear to be caused by an external adjuvant have been grouped into a complex syndrome referred to as autoimmune/inflammatory syndrome induced by adjuvants (ASIA). This syndrome may present with diverse clinical problems, which may include neurocognitive impairment, inflammatory musculoskeletal changes, and constitutional symptoms...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/26664526/breast-cancer-revealed-by-a-paraneoplastic-cerebellar-syndrome-about-one-case-and-literature-review
#20
REVIEW
Dembélé Adama, Bambara Moussa, Macoumi Emmanuel, Ullmann Dennis
To describe a case of breast cancer manifested by cerebellar syndrome and to establish a relationship between breast cancer and Paraneoplastic syndromes through the presence of anti- yo antibodies in serum and cerebrospinal fluid of a patient. Our patient was 52 years old, Multipara with 5 children alive. She had been 3 years post-menopausal under Hormonal Replacement Therapy. Weight: 46.7 Kg; Height: 1.60 m; Body Surface Area: 1.59 m(2). Nil history of alcohol or tobacco smoking. Nil history suggestive of malignancies or autoimmune diseases...
2015: Pan African Medical Journal
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