Xue Gong, Yaru Ma, Xiaolin Deng, Aiqing Li, Xingjie Li, Xueying Kong, Yue Liu, Xu Liu, Kundian Guo, Yuting Yang, Zhongxin Li, Hong Wei, Dong Zhou, Zhen Hong
Changes in the intestinal microbiota have been observed in patients with anti-N-methyl-D-aspartate receptor encephalitis (NMDARE). However, whether and how the intestinal microbiota is involved in the pathogenesis of NMDARE susceptibility needs to be demonstrated. Here, we first showed that germ-free (GF) mice that underwent fecal microbiota transplantation (FMT) from NMDARE patients, whose fecal microbiota exhibited low short-chain fatty acid content, decreased abundance of Lachnospiraceae, and increased abundance of Verrucomicrobiota, Akkermansia, Parabacteroides, Oscillospirales, showed significant behavioral deficits...
February 2024: Brain, Behavior, and Immunity