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https://www.readbyqxmd.com/read/27879670/the-protective-effects-of-icariin-against-the-homocysteine-induced-neurotoxicity-in-the-primary-embryonic-cultures-of-rat-cortical-neurons
#1
Xiao-Ang Li, Yuen-Shan Ho, Lei Chen, W L Wendy Hsiao
Icariin, an ingredient in the medicinal herb Epimedium brevicornum Maxim (EbM), has been considered as a potential therapeutic agent for neurodegenerative diseases such as Alzheimer's disease (AD). Hyperhomocysteinaemia is a risk factor for AD and other associated neurological diseases. In this study we aim to investigate whether icariin can reverse homocysteine (Hcy)-induced neurotoxicity in primary embryonic cultures of rat cortical neurons. Our findings demonstrated that icariin might be able restore the cytoskeleton network damaged by Hcy through the modulation of acetyl-α-tubulin, tyrosinated-α-tubulin, and phosphorylation of the tubulin-binding protein Tau...
November 22, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27878272/mir-20b-reduces-5-fu-resistance-by-suppressing-the-adam9-egfr-signaling-pathway-in-colon-cancer
#2
Qiang Fu, Jing Cheng, Jindai Zhang, Yonglei Zhang, Xiaobing Chen, Suxia Luo, Jianguo Xie
Chemoresistance is a major obstacle to cancer therapy including that of colon cancer (CC). Although the dysregulation of many miRNAs has been implicated in 5-fluorouracil (5-FU) resistance in CC cells, the specific role of miR-20b in chemoresistance has not been documented. In the present study, we first determined the expression of miR-20b by RT-PCR and the levels of a disintegrin and metalloprotease 9 (ADAM9) and epidermal growth factor receptor (EGFR) by western blotting in CC and adjacent non-cancerous tissues from 5-FU-sensitive or -resistant CC patients...
November 18, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27875993/a-transcriptome-based-model-of-central-memory-cd4-t-cell-death-in-hiv-infection
#3
Gustavo Olvera-García, Tania Aguilar-García, Fany Gutiérrez-Jasso, Iván Imaz-Rosshandler, Claudia Rangel-Escareño, Lorena Orozco, Irma Aguilar-Delfín, Joel A Vázquez-Pérez, Joaquín Zúñiga, Santiago Pérez-Patrigeon, Enrique Espinosa
BACKGROUND: Human central memory CD4 T cells are characterized by their capacity of proliferation and differentiation into effector memory CD4 T cells. Homeostasis of central memory CD4 T cells is considered a key factor sustaining the asymptomatic stage of Human Immunodeficiency Virus type 1 (HIV-1) infection, while progression to acquired immunodeficiency syndrome is imputed to central memory CD4 T cells homeostatic failure. We investigated if central memory CD4 T cells from patients with HIV-1 infection have a gene expression profile impeding proliferation and survival, despite their activated state...
November 22, 2016: BMC Genomics
https://www.readbyqxmd.com/read/27827458/microrna-126-overexpression-rescues-diabetes-induced-impairment-in-efferocytosis-of-apoptotic-cardiomyocytes
#4
Sahana Suresh Babu, Rajarajan A Thandavarayan, Darukeshwara Joladarashi, Prince Jeyabal, Shashirekha Krishnamurthy, Arvind Bhimaraj, Keith A Youker, Prasanna Krishnamurthy
Efferocytosis, a process of clearance of apoptotic cells by phagocytes, is essential for successful resolution of inflammation and maintenance of tissue homeostasis. Diabetes compromises the function of macrophages leading to adverse inflammatory response during wound healing, myocardial injury, atherosclerosis and autoimmune disorders. However, the effect of diabetes on macrophage-mediated efferocytosis of apoptotic cardiomyocytes (ACM) and the molecular mechanisms involved are not understood so far. In the present study we found that invitro efferocytosis of ACM was impaired in macrophages from db/db (diabetic) mice...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793842/kras-nf%C3%AE%C2%BAb-yy1-mir-489-signaling-axis-controls-pancreatic-cancer-metastasis
#5
Mo-Fang Liu, Peng Yuan, Xiao-Hong He, Ye-Fei Rong, Jing Cao, Yong Li, Yunping Hu, Yingbin Liu, Dangsheng Li, Wenhui Lou
KRAS activation occurring in over 90% of pancreatic ductal adenocarcinomas (PDAC) drives progression and metastasis, but the underlying mechanisms involved in these processes are still poorly understood. Here we show how KRAS acts through inflammatory NF-κB signaling to activate the transcription factor YY1, which represses expression of the tumor suppressor gene miR-489. In PDAC cells, repression of miR-489 by KRAS signaling inhibited migration and metastasis by targeting the extracellular matrix factors ADAM9 and MMP7...
October 28, 2016: Cancer Research
https://www.readbyqxmd.com/read/27779709/comparative-gene-expression-profiling-of-adams-mmps-timps-emmprin-egf-r-and-vegfa-in-low-grade-meningioma
#6
Harcharan K Rooprai, Andrew J Martin, Andrew King, Usha D Appadu, Huw Jones, Richard P Selway, Richard W Gullan, Geoffrey J Pilkington
MMPs (matrix metalloproteinases), ADAMs (a disintegrin and metalloproteinase) and TIMPs (tissue inhibitors of metalloproteinases) are implicated in invasion and angiogenesis: both are tissue remodeling processes involving regulated proteolysis of the extracellular matrix, growth factors and their receptors. The expression of these three groups and their correlations with clinical behaviour has been reported in gliomas but a similar comprehensive study in meningiomas is lacking. In this study, we aimed to evaluate the patterns of expression of 23 MMPs, 4 TIMPs, 8 ADAMs, selective growth factors and their receptors in 17 benign meningiomas using a quantitative real-time polymerase chain reaction (qPCR)...
October 18, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27770372/microrna-590-suppresses-the-tumorigenesis-and-invasiveness-of-non-small-cell-lung-cancer-cells-by-targeting-adam9
#7
Fei-Fei Wang, Song Wang, Wen-Hua Xue, Jing-Liang Cheng
microRNAs (miRNAs), a family of small non-coding RNA molecules, are implicated in cancer growth and progression. In the present study, we examined the expression and biological roles of miR-590 in non-small cell lung cancer (NSCLC). Compared to normal lung tissues, miR-590 expression was downregulated in primary NSCLCs and, to a greater extent, in corresponding brain metastases. NSCLC cell lines with high metastatic potential had significantly (P < 0.05) lower levels of miR-590 than those with low metastatic potential...
October 21, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27699237/platelet-integrin-%C3%AE-6%C3%AE-1-controls-lung-metastasis-through-direct-binding-to-cancer-cell-derived-adam9
#8
Elmina Mammadova-Bach, Paola Zigrino, Camille Brucker, Catherine Bourdon, Monique Freund, Adèle De Arcangelis, Scott I Abrams, Gertaud Orend, Christian Gachet, Pierre Henri Mangin
Metastatic dissemination of cancer cells, which accounts for 90% of cancer mortality, is the ultimate hallmark of malignancy. Growing evidence suggests that blood platelets have a predominant role in tumor metastasis; however, the molecular mechanisms involved remain elusive. Here, we demonstrate that genetic deficiency of integrin α6β1 on platelets markedly decreases experimental and spontaneous lung metastasis. In vitro and in vivo assays reveal that human and mouse platelet α6β1 supports platelet adhesion to various types of cancer cells...
September 8, 2016: JCI Insight
https://www.readbyqxmd.com/read/27692848/changes-in-expressions-of-adam9-10-and-17-as-well-as-%C3%AE-secretase-activity-in-renal-cell-carcinoma
#9
Nuray Erin, Tümay İpekçi, Bahar Akkaya, İrem Hicran Özbudak, Mehmet Baykara
BACKGROUND: ADAM9, 10, and 17 are a class of disintegrins and metallproteinases with α-secretase activity. There are conflicting results regarding the role(s) of ADAM9, 10, and 17 in carcinogenesis, and only a few studies have examined their levels and cellular localization in renal cell carcinoma (RCC). Studies examining changes in α-secretase activity in RCC compared to enzymatic activity of the uninvolved kidney are lacking. METHOD: A cross-sectional study was conducted in 56 patients undergoing radical nephrectomy after the diagnosis of RCC...
September 28, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27618097/effects-of-folic-acid-on-secretases-involved-in-a%C3%AE-deposition-in-app-ps1-mice
#10
Tian Tian, Dong Bai, Wen Li, Guo-Wei Huang, Huan Liu
Alzheimer's disease (AD) is the most common type of dementia. Amyloid-β protein (Aβ) is identified as the core protein of neuritic plaques. Aβ is generated by the sequential cleavage of the amyloid precursor protein (APP) via the APP cleaving enzyme (α-secretase, or β-secretase) and γ-secretase. Previous studies indicated that folate deficiency elevated Aβ deposition in APP/PS1 mice, and this rise was prevented by folic acid. In the present study, we aimed to investigate whether folic acid could influence the generation of Aβ by regulating α-, β-, and γ-secretase...
2016: Nutrients
https://www.readbyqxmd.com/read/27571068/adam9-expression-is-associate-with-glioma-tumor-grade-and-histological-type-and-acts-as-a-prognostic-factor-in-lower-grade-gliomas
#11
Xing Fan, Yongheng Wang, Chuanbao Zhang, Li Liu, Sen Yang, Yinyan Wang, Xing Liu, Zenghui Qian, Shengyu Fang, Hui Qiao, Tao Jiang
The A disintegrin and metalloproteinase 9 (ADAM9) protein has been suggested to promote carcinoma invasion and appears to be overexpressed in various human cancers. However, its role has rarely been investigated in gliomas and, thus, in the current study we have evaluated ADAM9 expression in gliomas and examined the relevance of its expression in the prognosis of glioma patients. Clinical characteristics, RNA sequence data, and the case follow-ups were reviewed for 303 patients who had histological, confirmed gliomas...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27554339/adam9-silencing-inhibits-breast-tumor-cells-transmigration-through-blood-and-lymphatic-endothelial-cells
#12
Kelli Cristina Micocci, Milene Nóbrega de Oliveira Moritz, Rafael Luis Bressani Lino, Laila Ribeiro Fernandes, Antonio Gilclêr Ferreira Lima, Camila Castro Figueiredo, Verônica Morandi, Heloisa Sobreiro Selistre-de-Araujo
ADAMs are transmembrane multifunctional proteins that contain disintegrin and metalloprotease domains. ADAMs act in a diverse set of biological processes, including fertilization, inflammatory responses, myogenesis, cell migration, cell proliferation and ectodomain cleavage of membrane proteins. These proteins also have additional functions in pathological processes as cancer and metastasis development. ADAM9 is a member of ADAM protein family that is overexpressed in several types of human carcinomas. The aim of this study was to investigate the role of ADAM9 in hematogenous and lymphatic tumor cell dissemination assisting the development of new therapeutic tools...
September 2016: Biochimie
https://www.readbyqxmd.com/read/27531893/collagen-xvii-laminin-5-activates-epithelial-to-mesenchymal-transition-and-is-associated-with-poor-prognosis-in-lung-cancer
#13
Chen-Chi Liu, Jiun-Han Lin, Tien-Wei Hsu, Jyuan-Wei Hsu, Jer-Wei Chang, Kelly Su, Han-Shui Hsu, Shih-Chieh Hung
Epithelial-to-mesenchymal transition (EMT) is associated with tumor metastasis and tumorigenesis in lung cancer stem-like cells (CSCs). However, the exact mechanism underlying this is not clear. We used microarray analysis to identify candidate genes responsible for EMT in spheroid and monolayer cultures of lung cancer cells. We found increased expression of a variety of adhesion molecules in CSCs. One of these molecules, Collagen XVII (Col XVII), was demonstrated to be required for maintenance of EMT phenotypes and metastasis ability in lung CSCs...
August 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27513359/age-dependent-changes-in-the-pulmonary-renin-angiotensin-system-are-associated-with-severity-of-lung-injury-in-a-model-of-acute-lung-injury-in-rats
#14
Laura R A Schouten, Hendrik J F Helmerhorst, Gerry T M Wagenaar, Tom Haltenhof, René Lutter, Joris J T H Roelofs, Job B M van Woensel, Anton H L C van Kaam, Albert P Bos, Marcus J Schultz, Thomas Walther, Roelie M Wösten-van Asperen
OBJECTIVES: A growing body of evidence suggests that age affects the main pathophysiologic mechanisms of the acute respiratory distress syndrome. This may imply the need for developing age-tailored therapies for acute respiratory distress syndrome. However, underlying molecular mechanisms governing age-related susceptibility first need to be unraveled. In a rat model of acute lung injury, we investigated whether age affects the balance between the two key enzymes of the pulmonary renin-angiotensin system, angiotensin-converting enzyme, and angiotensin-converting enzyme 2...
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27498787/microrna-140-represses-glioma-growth-and-metastasis-by-directly-targeting-adam9
#15
Xiaogang Liu, Shanjun Wang, Aiqin Yuan, Xunhui Yuan, Bing Liu
Glioma is the most frequent primary malignant tumor of the human brain. Recently, great progress has been made in the combined therapy of glioma. However, the clinical effects of these treatments and prognosis for patients with glioma remains poor. MicroRNAs (miRNAs) have been demonstrated to play important roles in the initiation and progression of various types of human cancers, also including glioma. The present study investigated the expression patterns of microRNA‑140 (miR-140) in glioma, and the roles of miR-140 in glioma cell proliferation, migration and invasion...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27338066/therapeutic-approaches-to-alzheimer-s-disease-through-stimulating-of-non-amyloidogenic-processing-of-amyloid-precursor-protein
#16
Y-Q Wang, D-H Qu, K Wang
Amyloid beta (Aβ) plaques are pathological hallmarks of neurodegenerative Alzheimer's disease (AD) that is predominantly characterized by clinical symptoms of dementia. Therapies targeting Aβ are essential for preventing and treating AD. This review focuses on the non-amyloidogenic pathways that prevent the generation of Aβ peptide and thereby plaque formation in AD. An a-secretase-dependent cleavage of Amyloid Precursor Protein (APP) precludes the amyloidogenic pathway of Aβ generation. This non-amyloidogenic a-secretase activation thereby secretes sAPPa with prominent neurotrophic and memory-enhancing properties...
June 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27334934/the-association-between-laminin-and-microglial-morphology-in-vitro
#17
Wing Yip Tam, Ngan Pan Bennett Au, Chi Him Eddie Ma
Microglia are immune cells in the central nervous system (CNS) that contribute to primary innate immune responses. The morphology of microglia is closely associated with their functional activities. The majority of microglial studies have focused on the ramified or amoeboid morphology; however, bipolar/rod-shaped microglia have recently received much attention. Bipolar/rod-shaped microglia form trains with end-to-end alignment in injured brains and retinae, which is proposed as an important mechanism in CNS repair...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27177841/an-improved-fluorescent-substrate-for-assaying-soluble-and-membrane-associated-adam-family-member-activities
#18
Marcia L Moss, Dmitriy Minond, Toshie Yoneyama, Hinrich P Hansen, Nikola Vujanovic, Fred H Rasmussen
A fluorescent resonance energy transfer substrate with improved sensitivity for ADAM17, -10, and -9 (where ADAM represents a disintegrin and metalloproteinase) has been designed. The new substrate, Dabcyl-Pro-Arg-Ala-Ala-Ala-Homophe-Thr-Ser-Pro-Lys(FAM)-NH2, has specificity constants of 6.3 (±0.3) × 10(4) M(-1) s(-1) and 2.4 (±0.3) × 10(3) M(-1) s(-1) for ADAM17 and ADAM10, respectively. The substrate is more sensitive than widely used peptides based on the precursor tumor necrosis factor-alpha (TNF-alpha) cleavage site, PEPDAB010 or Dabcyl-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Lys(FAM)-NH2 and Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa-Arg-Ser-Ser-Arg-NH2...
August 15, 2016: Analytical Biochemistry
https://www.readbyqxmd.com/read/27052751/integrated-data-set-of-micrornas-and-mrnas-involved-in-severe-intrauterine-adhesion
#19
Xin Liu, Hua Duan, Heng-Hui Zhang, Lu Gan, Qian Xu
BACKGROUND: Adhesion tissue is formed following injury to the uterine basal layer. Currently, there is no effective treatment for severe intrauterine adhesion (IUA), which causes loss of reproductive function. Enhanced understanding of the molecular mechanisms driving severe IUA would be beneficial for the treatment. METHODS: Differentially expressed microRNAs (miRNAs) and messenger RNAs (mRNAs) in severe IUA (n = 3) and normal (n = 3) endometrium were analyzed by high-throughput microarray analysis...
October 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27026568/disintegrin-and-metalloproteinases-adams-expression-in-gastroesophageal-reflux-disease-and-in-esophageal-adenocarcinoma
#20
T Kauttu, H Mustonen, S Vainionpää, L Krogerus, I Ilonen, J Räsänen, J Salo, P Puolakkainen
BACKGROUND: Clinically useful marker molecules for the progression of gastroesophageal reflux disease and Barrett's esophagus (BE) to esophageal adenocarcinoma (EAC) are lacking. Many adenocarcinomas and inflammatory conditions exhibit increased expression of ADAMs, 'a disintegrin and metalloproteinases'. METHODS: We assessed the expression of five ADAMs (9, 10, 12, 17, 19) in three esophageal cell lines (Het-1A, OE19, OE33) by RT-PCR and Western blotting, and in human samples of normal esophagus, esophagitis, BE, Barrett's dysplasia, and EAC by RT-PCR, and in selected samples by immunohistochemistry...
March 30, 2016: Clinical & Translational Oncology
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