keyword
MENU ▼
Read by QxMD icon Read
search

Three-dimensional

keyword
https://www.readbyqxmd.com/read/29793210/polypharmacological-profile-of-1-2-dihydro-2-oxo-pyridine-3-carboxamides-in-the-endocannabinoid-system
#1
Andrea Chicca, Chiara Arena, Simone Bertini, Francesca Gado, Elena Ciaglia, Mario Abate, Maria Digiacomo, Margherita Lapillo, Giulio Poli, Maurizio Bifulco, Marco Macchia, Tiziano Tuccinardi, Jürg Gertsch, Clementina Manera
The endocannabinoid system (ECS) represents one of the major neuromodulatory systems involved in different physiological and pathological processes. Multi-target compounds exert their activities by acting via multiple mechanisms of action and represent a promising pharmacological modulation of the ECS. In this work we report 4-substituted and 4,5-disubstituted 1,2-dihydro-2-oxo-pyridine-3-carboxamide derivatives with a broad spectrum of affinity and functional activity towards both cannabinoid receptors and additional effects on the main components of the ECS...
May 14, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29793097/quantitative-assessment-of-placental-perfusion-by-three-dimensional-power-doppler-ultrasound-for-twins-with-selective-intrauterine-growth-restriction-in-one-twin
#2
Wei Sun, Jingyi Liu, Ying Zhang, Ailu Cai, Zeyu Yang, Yili Zhao, Yu Wang, Zhe Cao, Qiuju Wei
OBJECTIVE: We quantitatively assessed placental perfusion using three-dimensional (3D) power Doppler ultrasound for twins with selective intrauterine growth restriction (sIUGR) in one twin. STUDY DESIGN: A prospective cross-sectional study was performed for 104 normal monochorionic diamniotic twins and 30 twins with sIUGR. Twins with sIUGR were divided into two groups: in group I (19 twins), both fetuses had continuous forward end-diastolic blood flow in the umbilical artery; in group II (11 twins), the smaller fetus had a loss or a reverse end-diastolic blood flow in the umbilical artery, but the larger fetus had continuous forward end-diastolic blood flow...
May 17, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29793090/anti-haemostatic-compounds-from-the-vampire-snail-cumia-reticulata-molecular-cloning-and-in-silico-structure-function-analysis
#3
Maria Vittoria Modica, Jonathan Reinoso Sánchez, Andrea Pasquadibisceglie, Marco Oliverio, Paolo Mariottini, Manuela Cervelli
Blood-feeding animals are known for their ability to produce bioactive compounds to impair haemostasis and suppress pain perception in the host. These compounds are extremely appealing for pharmacological development since they are generally very effective and specific for their molecular target. A preliminary RNA-Seq based characterization of the secretion from salivary and mid-oesophageal tissues of the vampire snail Cumia reticulata, revealed a complex mixture of feeding-related transcripts with potential anaesthetic and anticoagulant action...
May 16, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29793060/a-computational-framework-for-the-detection-of-subcortical-brain-dysmaturation-in-neonatal-mri-using-3d-convolutional-neural-networks
#4
Rafael Ceschin, Alexandria Zahner, William Reynolds, Jenna Gaesser, Giulio Zuccoli, Cecilia W Lo, Vanathi Gopalakrishnan, Ashok Panigrahy
Deep neural networks are increasingly being used in both supervised learning for classification tasks and unsupervised learning to derive complex patterns from the input data. However, the successful implementation of deep neural networks using neuroimaging datasets requires adequate sample size for training and well-defined signal intensity based structural differentiation. There is a lack of effective automated diagnostic tools for the reliable detection of brain dysmaturation in the neonatal period, related to small sample size and complex undifferentiated brain structures, despite both translational research and clinical importance...
May 21, 2018: NeuroImage
https://www.readbyqxmd.com/read/29793018/image-fusion-and-3d-roadmapping-in-endovascular-surgery
#5
Douglas W Jones, Lars Stangenberg, Nicholas J Swerdlow, Matthew Alef, Ruby Lo, Fahad Shuja, Marc L Schermerhorn
Practitioners of endovascular surgery have historically utilized two-dimensional (2D) intraoperative fluoroscopic imaging, with intra-vascular contrast opacification, to treat complex three-dimensional (3D) pathology. Recently, major technical developments in intraoperative imaging have made image fusion techniques possible: the creation of a 3D patient-specific vascular roadmap based on preoperative imaging which aligns with intraoperative fluoroscopy, with many potential benefits. First, a 3D model is segmented from preoperative imaging, typically a CT scan...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792986/model-based-nir-spectroscopy-implementation-for-in-line-assay-monitoring-during-a-pharmaceutical-suspension-manufacturing-process
#6
Maxim Verstraeten, Daan Van Hauwermeiren, Mario Hellings, Eline Hermans, Jeroen Geens, Chris Vervaet, Ingmar Nopens, Thomas De Beer
The implementation of Process Analytical Technology (PAT) instruments is generally achieved stochastically. Sub-optimal PAT locations could introduce variation in the measurements which is not related to the analyte of interest. For this reason, rational approaches should be considered to establish an optimal sensor placement where relevant measurements are possible and the impact of disturbances is minimized. The aim of this paper is to demonstrate how mechanistic modelling can support appropriate sensor implementation by means of a case study...
May 21, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29792820/hydrogel-tissue-chemistry-principles-and-applications
#7
Viviana Gradinaru, Jennifer Treweek, Kristin Overton, Karl Deisseroth
Over the past five years, a rapidly developing experimental approach has enabled high-resolution and high-content information retrieval from intact multicellular animal (metazoan) systems. New chemical and physical forms are created in the hydrogel-tissue chemistry process, and the retention and retrieval of crucial phenotypic information regarding constituent cells and molecules (and their joint interrelationships) are thereby enabled. For example, rich data sets defining both single-cell-resolution gene expression and single-cell-resolution activity during behavior can now be collected while still preserving information on three-dimensional positioning and/or brain-wide wiring of those very same neurons-even within vertebrate brains...
May 20, 2018: Annual Review of Biophysics
https://www.readbyqxmd.com/read/29792720/-experimental-processing-of-corrosion-casts-of-large-animal-organs
#8
R Pálek, V Liška, L Eberlová, H Mírka, M Svoboda, S Haviar, M Emingr, O Brzoň, P Mik, V Třeška
INTRODUCTION: Corrosion casts (CCs) are used for the visualization and assessment of hollow structures. CCs with filled capillaries enable (with the help of imaging methods) to obtain data for mathematical organ perfusion modelling. As the processing is more difficult in case of organs with greater volume of the vasculature, mainly organs from small animals have been cast up to now. The aim of this study was to optimize the protocol of corrosion casting of different organs of pig. Porcine organs are relatively easily accessible and frequently used in experimental medicine...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29792677/ultra-low-power-smart-electronic-nose-system-based-on-three-dimensional-tin-oxide-nanotube-arrays
#9
Jiaqi Chen, Zhuo Chen, Farid Boussaid, Daquan Zhang, Xiaofang Pan, Huijuan Zhao, Amine Bermak, Chi-Ying Tsui, Xinran Wang, Zhiyong Fan
In this work, we present a high performance smart electronic nose (E-nose) system consisting of multiplexed tin dioxide (SnO2) nanotube sensor array, read-out circuit, wireless data transmission unit, mobile phone receiver and data processing application (App). Using the proposed nanotube sensor device structure in conjunction with multiple electrode materials, high sensitivity gas detection and discrimination have been achieved at room temperature, enabling a 1,000 times reduction of sensor's power consumption as compared to a conventional device using thin film SnO2...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792414/hybrid-assembly-of-different-sized-supertetrahedral-clusters-into-a-unique-non-interpenetrated-mn-in-s-open-framework-with-large-cavity
#10
Hongxiang Wang, Wei Wang, Dandan Hu, Min Luo, Chaozhuang Xue, Dongsheng Li, Tao Wu
Reported here is a unique crystalline semiconductor open-framework material built from the large-sized supertetrahedral T4 and T5 clusters with the Mn-In-S compositions. The hybrid assembly between T4 and T5 clusters by sharing terminal μ2 -S2- is for the first time observed among the cluster-based chalcogenide open frameworks. Such three-dimensional structure displays non-interpenetrated diamond-type topology with extra-large nonframework volume of 82%. Moreover, ion exchange, CO2 adsorption, as well as photoluminescence properties of the title compound are also investigated...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792383/donor-variation-and-optimization-of-human-mesenchymal-stem-cells-chondrogenesis-in-hyaluronic-acid
#11
Minwook Kim, Isaac E Erickson, Alice H Huang, Sean T Garrity, Robert L Mauck, David R Steinberg
Mesenchymal stem cells (MSCs) are an attractive cell type for cartilage repair that can undergo chondrogenesis in a variety of three dimensional (3D) scaffolds. Hyaluronic acid (HA) hydrogels provide a biologically relevant interface for cell encapsulation. While our previous studies have shown that MSC-laden HA constructs can mature in vitro to match native mechanical properties using cells from animal sources, clinical application will depend on the successful translation of these findings to human cells...
May 24, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29792285/associations-between-trunk-postural-control-in-walking-and-unstable-sitting-at-various-levels-of-task-demand
#12
Julian C Acasio, Courtney M Butowicz, Pawel R Golyski, Maury A Nussbaum, Brad D Hendershot
Trunk postural control (TPC) has been investigated in several populations and tasks. Previous work observed targeted training of TPC via isolated trunk control tasks may improve performance in other activities (e.g., walking). However, the nature of this relationship remains unknown. We therefore investigated the relationship between TPC, at both the global (i.e., response to finite perturbations) and local (i.e., resistance to continuous perturbations) levels, during walking and unstable sitting, both at varying levels of task demand...
May 21, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29792211/the-impact-of-ankle-foot-orthoses-on-toe-clearance-strategy-in-hemiparetic-gait-a-cross-sectional-study
#13
Kannit Pongpipatpaiboon, Masahiko Mukaino, Fumihiro Matsuda, Kei Ohtsuka, Hiroki Tanikawa, Junya Yamada, Kazuhiro Tsuchiyama, Eiichi Saitoh
BACKGROUND: Ankle-foot orthoses (AFOs) are frequently used to improve gait stability, toe clearance, and gait efficiency in individuals with hemiparesis. During the swing phase, AFOs enhance lower limb advancement by facilitating the improvement of toe clearance and the reduction of compensatory movements. Clinical monitoring via kinematic analysis would further clarify the changes in biomechanical factors that lead to the beneficial effects of AFOs. The purpose of this study was to investigate the actual impact of AFOs on toe clearance, and determine the best strategy to achieve toe clearance (including compensatory movements) during the swing phase...
May 23, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29792041/increased-diagnostic-confidence-in-the-diagnosis-of-pituitary-micro-lesions-with-the-addition-of-three-dimensional-sampling-perfection-with-application-optimized-contrasts-using-different-flip-angle-evolutions-sequences
#14
Ying Tang, Yue Wu, Hua Zhang, Jing Wang, ZhenWei Yao
Background Conventional magnetic resonance imaging (MRI) is adversely affected by thick slices, small intersection gaps, and the partial volume effect, leading to the missed diagnosis or misdiagnosis of pituitary micro-lesions. Purpose To evaluate the diagnostic yield of three-dimensional sampling perfection with application-optimized contrasts using different flip-angle evolutions (3D-T2 SPACE) sequences compared with a standard MRI protocol for the diagnosis of pituitary micro-lesions. Material and Methods The MRI findings of 664 patients with clinically suspected pituitary lesions were retrospectively analyzed...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29791698/stryker-orthopaedic-modeling-and-analytics-soma-a-review
#15
Walter Schmidt, Sally LiArno, Anton Khlopas, Andreas Petersik, Michael A Mont
Due to the differences in bone morphology between demographics such as age, gender, body mass index, and ethnicity, the development of orthopaedic implants requires a large number of anatomical data from various patient populations. In an effort to assess these demographic variations, Stryker Orthopaedic Modeling and Analytics (SOMA) has been developed. SOMA is a suite of tools which utilizes a comprehensive database of computed tomography scans (CT-scans), plus associated three-dimensional (3D) bone models, allowing the user to assess population differences in bone morphology, bone density, and implant fit for the purposes of research and development...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791686/extruded-upper-first-molar-intrusion-comparison-between-unilateral-and-bilateral-miniscrew-anchorage
#16
Mari Miura Sugii, Bruno de Castro Ferreira Barreto, Waldemir Francisco Vieira-Júnior, Katia Regina Izola Simone, Ataís Bacchi, Ricardo Armini Caldas
OBJECTIVE: The aim of his study was to evaluate the stress on tooth and alveolar bone caused by orthodontic intrusion forces in a supraerupted upper molar, by using a three-dimensional Finite Element Method (FEM). METHODS: A superior maxillary segment was modeled in the software SolidWorks 2010 (SolidWorks Corporation, Waltham, MA, USA) containing: cortical and cancellous bone, supraerupted first molar, periodontal tissue and orthodontic components. A finite element model has simulated intrusion forces of 4N onto a tooth, directed to different mini-screw locations...
January 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29791504/periconceptional-maternal-dairy-rich-dietary-pattern-is-associated-with-prenatal-cerebellar-growth
#17
Francesca Parisi, Melek Rousian, Irene V Koning, Sten P Willemsen, Jeanne H M de Vries, Eric A P Steegers, Régine P M Steegers-Theunissen
BACKGROUND: Maternal nutrition during pregnancy has been related to intrauterine brain development and neurodevelopmental disabilities in adult life. We aim to investigate associations between periconceptional maternal dietary patterns and prenatal cerebellar growth from the first trimester onwards. MATERIALS AND METHODS: 126 women with singleton non-malformed pregnancies were enrolled before 8 weeks of gestation in the Rotterdam periconceptional cohort between 2013 and 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29791409/measurement-of-three-dimensional-wavefronts-using-the-ichikawa-lohmann-takeda-solution-to-the-irradiance-transport-equation
#18
J A Arriaga-Hernández, F Granados-Agustín, A Cornejo-Rodríguez
In this paper, we use the irradiance transport equation and the Fourier transform-based experimental solution given by Ichikawa-Lohmann-Takeda. We analyze experimental factors such as the digital filter, the introduced error for the rotation and period of the Ronchi ruling, and a new method is demonstrated for the measurement of 3D wavefront information.
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791391/effects-of-aberrations-on-effective-point-spread-function-in-sted-microscopy
#19
Yanghui Li, Hui Zhou, Xiaoyu Liu, Yuxue Li, Le Wang
Like other imaging techniques, stimulated emission depletion (STED) microscopy suffers from aberrations. While their effects on depletion patterns have been explicitly investigated, the study on how aberrations affect the effective point spread function (PSF) in STED microscopy is still missing. For STED researchers, however, this study is beneficial, as it directly bridges image qualities and aberrations. In this paper, we quantitatively analyze the effects of primary aberrations, including astigmatism, coma, trefoil, and spherical aberration, in two-dimensional (2D) and three-dimensional (3D) STED microscopy, and further discuss the corresponding aberration tolerance...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791386/single-frequency-3d-synthetic-aperture-imaging-with-dynamic-metasurface-antennas
#20
Michael Boyarsky, Timothy Sleasman, Laura Pulido-Mancera, Aaron V Diebold, Mohammadreza F Imani, David R Smith
Through aperture synthesis, an electrically small antenna can be used to form a high-resolution imaging system capable of reconstructing three-dimensional (3D) scenes. However, the large spectral bandwidth typically required in synthetic aperture radar systems to resolve objects in range often requires costly and complex RF components. We present here an alternative approach based on a hybrid imaging system that combines a dynamically reconfigurable aperture with synthetic aperture techniques, demonstrating the capability to resolve objects in three dimensions (3D), with measurements taken at a single frequency...
May 20, 2018: Applied Optics
keyword
keyword
34200
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"