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https://www.readbyqxmd.com/read/28317592/long-term-prognostic-value-of-preoperative-anemia-in-patients-with-colorectal-cancer-a-systematic-review-and-meta-analysis
#1
REVIEW
M J Wilson, M van Haaren, J J Harlaar, Hee Chul Park, H J Bonjer, J Jeekel, J J Zwaginga, M Schipperus
OBJECTIVE: To evaluate the long-term prognostic factor of preoperative anemia in colorectal cancer patients. BACKGROUND: Anemia is frequently observed in colorectal cancer patients, with a case incidence of 30 to 67 percent. Besides an indicator of tumor-induced blood loss and inflammation, anemia in cancer is also suggested to be a cause of inferior outcome, possibly via worsening of tumor hypoxia. As surgery is likely to enhance anemia, the long-term prognostic value of preoperative anemia seems most interesting...
March 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28316152/-long-term-follow-up-to-identify-the-rectal-potentially-malignant-nodules-in-female-by-digital-rectal-examination
#2
S S Wang, J Y Zhou, Z J Wang, S R Su, J Sun, R G W Sharen
Objective: To investigate the characteristics of the rectal potentially malignant nodules in female by digital rectal examination (DRE). Methods: Retrospectively, we collected the medical information and follow-up of rectal nodules cases diagnosed as benign by DRE during the health check-up in our hospital from Jan 2002 to Dec 2015. All nodules were recorded position, size, shape, hardness and mobility. Statistical analysis was performed to select the potentially malignant cases of postoperative pathological diagnosis and disappeared nodules followed up by DRE...
March 14, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28314318/systemic-inflammatory-response-after-preoperative-chemoradiotherapy-can-affect-oncologic-outcomes-in-locally-advanced-rectal-cancer
#3
In Hee Lee, Soyoon Hwang, Soo Jung Lee, Byung Woog Kang, Dongwon Baek, Hye Jin Kim, Su Yeon Park, Jun Seok Park, Gyu Seog Choi, Jae Chul Kim, Seung Hyun Cho, Jong Gwang Kim
AIM: Systemic inflammatory response (SIR) has been reported to be an important determinant of disease progression and survival in patients with colorectal cancer. This study investigated the prognostic relevance of changes in the platelet count on survival and the predictive value of changes in platelet/lymphocyte ratio (PLR) and neutrophil/lymphocyte ratio (NLR) on the pathological tumor response to preoperative chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (LARC)...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28314302/kras-mutant-status-may-be-associated-with-distant-recurrence-in-early-stage-rectal-cancer
#4
Michail Sideris, Jane Moorhead, Salvador Diaz-Cano, Amyn Haji, Savvas Papagrigoriadis
BACKGROUND/AIM: Total mesorectal excision combined with neo-adjuvant chemoradiotherary (CRT) and adjuvant chemotherapy, has been the standard treatment of locally advanced rectal cancer (LARC). Although TNM (Tumor, Node, Metastasis) classification for malignant Tumors is still the cornerstone in rectal cancer staging, there has been an effort to identify molecular biomarkers with additional prognostic or predictive value. MATERIALS AND METHODS: We retrospectively analyzed molecular biomarkers on prospectively collected histological specimens and clinical data from a cohort of 135 consecutive rectal cancer cases who underwent radical excision in a tertiary center between 2011-2014 (males=87, females=48, age range=22-89 years, mean=64,67 years, SD=13...
March 2017: Anticancer Research
https://www.readbyqxmd.com/read/28302932/successful-resection-of-a-large-rectal-adenoma-using-the-transsacral-approach
#5
Takuya Horio, Yosuke Oka, Ichitaro Shiratsuchi, Kouhei Saisho, Yuutarou Mihara, Reiichirou Kondo, Tetsushi Kinugusa, Jun Akiba, Yoshito Akagi
The transsacral approach is not routinely used for treating rectal tumors. We report the case of a 65-year-old man with a large adenoma at the posterior wall of the mid-rectum who was treated via the transsacral approach. The same lesion had been treated using transsacral endoscopic microsurgery 8 years previously. Moreover, 11 years previously he had undergone a laparotomy for bladder cancer, and an Indiana pouch had been constructed. Abdominal computed tomography showed that the pouch was adjacent to the rectum...
March 15, 2017: Kurume Medical Journal
https://www.readbyqxmd.com/read/28301974/folfox-and-intensified-split-course-chemoradiation-as-initial-treatment-for-rectal-cancer-with-synchronous-metastases
#6
T Bird, M Michael, M Bressel, J Chu, S Chander, P Cooray, J McKendrick, M Jefford, A Heriot, M Steel, T Leong, S Ngan
BACKGROUND: Optimal initial management of rectal carcinoma with synchronous metastases (RCSM) is controversial - both for patients being treated with curative and palliative intent. This study aims to evaluate the use of an upfront treatment strategy combining FOLFOX chemotherapy with split-course pelvic chemoradiation (FOLFOX + CRT) for patients with RCSM. MATERIAL AND METHODS: An analysis of all patients who commenced treatment with FOLFOX + CRT at our institutions between January 2009 and June 2014 was performed...
March 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28300658/effect-of-particle-size-on-the-biodistribution-toxicity-and-efficacy-of-drug-loaded-polymeric-nanoparticles-in-chemoradiotherapy
#7
Joseph M Caster, Stephanie K Yu, Artish N Patel, Nicole J Newman, Zachary J Lee, Samuel B Warner, Kyle T Wagner, Kyle C Roche, Xi Tian, Yuanzeng Min, Andrew Z Wang
Nanoparticle (NP) therapeutics can improve the therapeutic index of chemoradiotherapy (CRT). However, the effect of NP physical properties, such particle size, on CRT is unknown. To address this, we examined the effects of NP size on biodistribution, efficacy and toxicity in CRT. PEG-PLGA NPs (50, 100, 150nm mean diameters) encapsulating wotrmannin (wtmn) or KU50019 were formulated. These NP formulations were potent radiosensitizers in vitro in HT29, SW480, and lovo rectal cancer lines. In vivo, the smallest particles avoided hepatic and splenic accumulation while more homogeneously penetrating tumor xenografts than larger particles...
March 11, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28297071/association-between-smoking-at-diagnosis-and-cause-specific-survival-in-patients-with-rectal-cancer-results-from-a-population-based-analysis-of-10-794-cases
#8
Linda Sharp, Joseph McDevitt, Christopher Brown, Anne-Elie Carsin, Harry Comber
BACKGROUND: Currently, the 5-year survival rate for rectal cancer remains at <60%. The identification of potentially modifiable prognostic factors would be of considerable public health importance. A few studies have suggested associations between smoking and survival in rectal cancer; however, the evidence is inconsistent, and most of these studies were relatively small. In a large population-based cohort study, we investigated whether smoking at diagnosis is an independent prognostic factor for cancer-specific survival in rectal cancer and whether the association varies by sex, age, or treatment...
March 15, 2017: Cancer
https://www.readbyqxmd.com/read/28295403/toward-a-3d-transrectal-ultrasound-system-for-verification-of-needle-placement-during-high-dose-rate-interstitial-gynecologic-brachytherapy
#9
Jessica Robin Rodgers, Kathleen Surry, Eric Leung, David D'Souza, Aaron Fenster
PURPOSE: Treatment for gynecologic cancers, such as cervical, recurrent endometrial, and vaginal malignancies, commonly includes external-beam radiation and brachytherapy. In high-dose-rate (HDR) interstitial gynecologic brachytherapy, radiation treatment is delivered via hollow needles that are typically inserted through a template on the perineum with a cylinder placed in the vagina for stability. Despite the need for precise needle placement to minimize complications and provide optimal treatment, there is no standard intra-operative image-guidance for this procedure...
March 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/28294676/-treatment-results-of-patients-with-rectum-tumor-in-a-city-hospital
#10
Zoltán Banai, Béla Lestár, Lajos Berczi, József Földi, Zsigmond Harkai, Tibor Karácsony
INTRODUCTION: Two hundred and three patients were operated on with rectal malignancy between 2007 and 2014 in our surgical department. METHODS: Of these, patients who had cancer within 16 cm of the anal verge were included. 73 patients received neoadjuvant treatment and 130 patients were treated with primary resection. The specimens were graded by the Dworak and the Rödel regression score system. RESULTS: We found strong response in 45 patients and pathologic complete remission in three patients...
March 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28293971/a-modeling-study-of-functional-magnetic-resonance-imaging-to-individualize-target-definition-of-seminal-vesicles-for-external-beam-radiotherapy
#11
Sidsel Damkjær, Jakob B Thomsen, Svetlana I Petersen, Jens Peter Bangsgaard, Peter M Petersen, Ivan R Vogelius, Marianne C Aznar
BACKGROUND: Pre-treatment magnetic resonance imaging (MRI) can give patient-specific evaluation of suspected pathologically involved volumes in the seminal vesicles (SV) in prostate cancer patients. By targeting this suspicious volume we hypothesize that radiotherapy is more efficient without introducing more toxicity. In this study we evaluate the concept of using MRI-defined target volumes in terms of tumor control probability (TCP) and rectal normal tissue complication probability (NTCP)...
March 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28293088/do-pathological-variables-have-prognostic-significance-in-rectal-adenocarcinoma-treated-with-neoadjuvant-chemoradiotherapy-and-surgery
#12
Luca Reggiani Bonetti, Simona Lionti, Federica Domati, Valeria Barresi
AIM: To clarify which factors may influence pathological tumor response and affect clinical outcomes in patients with locally advanced rectal carcinoma treated with neo-adjuvant chemoradiotherapy and surgery. METHODS: Tumor regression grade (TRG) according to the Dworak system and yTNM stage were assessed and correlated with pre-treatment clinico-pathological variables in 215 clinically locally advanced (cTNM stage II and III) rectal carcinomas. Prognostic value of all pathological and clinical factors on disease free survival (DFS) and cancer specific survival (CSS) was analyzed by Kaplan Meier and Cox-regression analyses...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28291841/prognosis-of-locally-advanced-rectal-cancer-can-be-predicted-more-accurately-using-pre-and-post-chemoradiotherapy-neutrophil-lymphocyte-ratios-in-patients-who-received-preoperative-chemoradiotherapy
#13
SooYoon Sung, Seok Hyun Son, Eun Young Park, Chul Seung Kay
PURPOSE: The neutrophil-lymphocyte ratio (NLR) has been suggested as an inflammation-related factor, but also as an indicator of systemic anti-tumor immunity. We aimed to evaluate the prognostic value of the NLR and to propose a proper cut-off value in patients with locally advanced rectal cancer who received preoperative chemoradiation (CRT) followed by curative total mesorectal excision (TME). METHODS: A total of 110 rectal cancer patients with clinical T3-4 or node-positive disease were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28289660/transanal-endoscopic-microsurgery-for-patients-with-rectal-tumors-a-single-institution-s-experience
#14
Audrius Dulskas, Alfredas Kilius, Kestutis Petrulis, Narimantas E Samalavicius
PURPOSE: The purpose of this study was to look at our complication rates and recurrence rates, as well as the need for further radical surgery, in treating patients with benign and early malignant rectal tumors by using transanal endoscopic microsurgery (TEM). METHODS: Our study included 130 patients who had undergone TEM for rectal adenomas and early rectal cancer from December 2009 to December 2015 at the Department of Surgical Oncology, National Cancer Institute, Lithuania...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28284574/comparison-of-5-fu-based-and-capecitabine-based-neoadjuvant-chemoradiotherapy-in-patients-with-rectal-cancer-a-meta-analysis
#15
Xiang-Cai Zou, Qiwen Wang, Jimin Zhang
INTRODUCTION: The inconvenience of using infusion therapies resulted in the development of capecitabine (CA), an oral fluoropyrimidine. In this meta-analysis, we evaluated 10 studies that compared the efficacy and safety of an oral CA-based regimen with those of a continuous infusion 5-fluorouracil (5-FU) regimen for neoadjuvant chemoradiotherapy in patients with rectal cancer. MATERIALS AND METHODS: The databases searched included Medline, Cochrane, EMBASE, and Google Scholar (until August 31, 2016)...
January 25, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28283864/lower-gastrointestinal-neuroendocrine-neoplasms-associated-with-hereditary-cancer-syndromes-a-case-series
#16
Trilokesh D Kidambi, Christina Pedley, Amie Blanco, Emily K Bergsland, Jonathan P Terdiman
Lower gastrointestinal (GI) neuroendocrine neoplasms (NENs) of the colon and rectum are uncommon and not traditionally associated with hereditary GI cancer syndromes. However, with widespread implementation of colorectal cancer screening programs, lower GI NENs are being identified with increasing frequency. We report the first case series of six patients with lower GI NENs who were diagnosed with hereditary GI cancer syndromes by germline testing. Two patients presented with poorly differentiated rectal neuroendocrine carcinoma (NECs) with colonic polyposis and were found to have Familial Adenomatous Polyposis and MYH-Associated Polyposis, respectively...
March 10, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28280982/risk-factors-for-anastomotic-leakage-after-laparoscopic-surgery-with-the-double-stapling-technique-for-stage-0-i-rectal-carcinoma-a-subgroup-analysis-of-a-multicenter-single-arm-phase-ii-trial
#17
Keitaro Tanaka, Junji Okuda, Seiichiro Yamamoto, Masaaki Ito, Kazuhiro Sakamoto, Yukihito Kokuba, Kenichi Yoshimura, Masahiko Watanabe
PURPOSE: The aim of this study was to determine the risk factors for anastomotic leakage after laparoscopic rectal surgery. METHODS: We conducted a prospective trial involving 395 patients with stage 0/I rectal carcinoma who underwent laparoscopic low anterior resection using a double stapling technique. Data concerning variables related to patient background, tumors and surgical factors were evaluated. The outcomes with respect to anastomotic leakage were recorded, and univariate and multivariate analyses were performed to identify relevant risk factors...
March 9, 2017: Surgery Today
https://www.readbyqxmd.com/read/28280625/defining-the-distal-margin-of-rectal-cancer-for-surgical-planning
#18
Sumito Sato, Takashi Kato, Jun-Ichi Tanaka
Accurate measurement of the distal rectal tumor margin is essential in selecting the appropriate surgical procedure. However, there is no standard measurement method. The National Cancer Institute consensus group recommends use of the anal verge (AV) as a landmark, and the European Society of Gastrointestinal and Abdominal Radiology recommends use of the anorectal ring (ARR). In addition, whether measurements should be made on double contrast barium enema (BE) radiographs or magnetic resonance (MR) images remains controversial...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28280608/prognostic-influence-of-histopathological-regression-patterns-in-rectal-adenocarcinoma-receiving-neoadjuvant-therapy
#19
Ma Jesús Fernández-Aceñero, Lourdes Estrada Muñoz, Javier Sastre Varela, Juan Antonio Corona Sánchez, Cristina Díaz Del Arco, Beatriz García Paredes, Sofía Córdoba Largo, Laura Del Puerto Nevado
BACKGROUND: Neoadjuvant chemoradiation therapy (CRT) is an important management strategy in rectal carcinoma. Different systems grading response have shown varying prognostic influence. METHODS: To analyze the prognostic influence of pathological response in a series of 183 patients with rectal carcinoma receiving neoadjuvant therapy. To determine the prognostic significance of the histopathological patterns of response. RESULTS: A total of 183 patients from two hospitals...
February 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28277833/capecitabine-in-locally-advanced-anal-cancer-do-we-need-randomised-evidence
#20
Li Chia Chong, Tabitha Healey, Tony Michele, Timothy J Price
Standard treatment for locally advanced anal cancer is chemoradiotherapy with mitomycin C and fluorouracil. However, infusional fluorouracil requires central venous catheter placement potentiating risk of infection and thrombosis. Capecitabine which is an oral tumor activated fluoropyrimidine carbamate is an established treatment alternative to infusional fluorouracil for patients with gastrointestinal cancers. Areas covered: This review examines and discusses the current evidence for substitution of Capecitabine for infusional fluorouracil in locally advanced anal cancer...
March 13, 2017: Expert Review of Anticancer Therapy
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