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https://www.readbyqxmd.com/read/29221809/acute-pain-and-peripheral-sensitization-following-cautery-disbudding-in-1-and-4-week-old-calves
#1
Mirra Alessandro, Spadavecchia Claudia, Bruckmaier Rupert, Gutzwiller Andreas, Casoni Daniela
Acute pain and peripheral sensitization development after cautery disbudding was investigated in 33 calves administered preventive multimodal analgesia. The animals were assigned randomly to three groups: 1) Group SH (Control), undergoing sham disbudding at 1 and 4weeks of age; 2) Group ED (Early Disbudding), undergoing disbudding at 1week of age and sham disbudding at 4weeks of age; 3) Group LD (Late Disbudding), undergoing sham disbudding at 1week of age and disbudding at 4weeks of age. Physiological parameters (heart rate, respiratory rate, rectal temperature, invasive blood pressure, cortisol, β-endorphin, interleukin-1β, interleukin-6, tumor necrosis factor-α and haptoglobin plasmatic concentration), local variables (tactile sensitivity score, pressure pain thresholds and horn temperature), behavior and pain scores [multidimensional pain scale and visual analogue scale (VAS)] were assessed at baseline and at several pre-determined time points until 24h after disbudding...
December 5, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29221180/pelvic-recurrence-after-definitive-surgery-for-locally-advanced-rectal-cancer-a-retrospective-investigation-of-implications-for-precision-radiotherapy-field-design
#2
Chao Li, Yinju Zhu, Tong Tong, Ye Xu, Yun Guan, Jingwen Wang, Huankun Wang, Ji Zhu
Background: To analyze the local distribution of pelvic recurrence after total mesorectal excision, with a view to simplifying the formulation of optimal individualized radiotherapy plans. Methods: We retrospectively investigated the data of 168 patients diagnosed with recurrent pelvic cancer treated at Fudan University Shanghai Cancer Center between January 2008 and December 2012. The following were collected depending on availability: operative report, histological report, specimen photographs, initial preoperative images, images confirming local recurrence, and clinical history...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29217764/radiotherapy-activated-cancer-associated-fibroblasts-promote-tumor-progression-through-paracrine-igf-1r-activation
#3
Joke Tommelein, Elly De Vlieghere, Laurine Verset, Elodie Melsens, Justine Leenders, Benedicte Descamps, Annelies Debucquoy, Christian Vanhove, Patrick Pauwels, Christian P Gespach, Anne Vral, Astrid De Boeck, Karin Haustermans, Pascal de Tullio, Wim Ceelen, Pieter Demetter, Tom Boterberg, Marc Bracke, Olivier De Wever
Preoperative radiotherapy (RT) is a mainstay in the management of rectal cancer (RC), a tumor characterized by desmoplastic stroma containing cancer-associated fibroblasts (CAF). Although CAF are abundantly present, the effects of RT to CAF and its impact on cancer cells are unknown. We evaluated the damage responses of CAF to RT and investigated changes in colorectal cancer (CRC) cell growth, transcriptome, metabolome, and kinome in response to paracrine signals emerging from irradiated CAF. RT to CAF induced DNA damage, p53 activation, cell cycle arrest, and secretion of paracrine mediators including insulin-like growth factor-1 (IGF-1)...
December 7, 2017: Cancer Research
https://www.readbyqxmd.com/read/29217398/is-neoadjuvant-chemoradiation-with-dose-escalation-and%C3%A2-consolidation-chemotherapy-sufficient-to-increase-surgery-free-and-distant-metastases-free-survival-in-baseline%C3%A2-ct3-rectal-cancer
#4
Guilherme Pagin São Julião, Angelita Habr-Gama, Bruna Borba Vailati, Patricia Bailão Aguilar, Jorge Sabbaga, Sérgio Eduardo Alonso Araújo, Adrian Mattacheo, Flavia Andrea Alexandre, Laura Melina Fernandez, Diogo Bugano Gomes, Joaquim Gama-Rodrigues, Rodrigo Oliva Perez
Patients with cT3 rectal cancer are less likely to develop complete response to neoadjuvant chemoradiation (nCRT) and still face significant risk for systemic relapse. In this setting, radiation (RT) dose-escalation and consolidation chemotherapy in "extended" nCRT regimens have been suggested to improve primary tumor response and decrease the risks of systemic recurrences. For these reasons we compared surgery-free and distant-metastases free survival among cT3 patients undergoing standard or extended nCRT...
November 26, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29214774/correlation-of-cancer-stem-cell-markers-oct4-sox2-and-nanog-with-clinicopathological-features-and-prognosis-in-operative-patients-with-rectal-cancer
#5
Liuping You, Xin Guo, Yuenan Huang
PURPOSE: To investigate the association of cancer stem-cell markers [octamer-binding transcription factor 4 (OCT4), sex determining region Y-box 2 (SOX2), and Nanog homebox (NANOG)] expression with clinicopathological properties and overall survival (OS) in operative rectal cancer (RC) patients receiving adjuvant therapy. MATERIALS AND METHODS: 153 patients with primary RC receiving surgery were enrolled. Tumor tissue and paired adjacent normal tissue sample were collected, and OCT4, SOX2, and NANOG expressions were assessed by immunofluorescent staining...
January 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29211355/tumor-marker-%C3%AE-fetoprotein-receptor-does-not-discriminate-between-benign-prostatic-disease-and-prostate-cancer
#6
Tomaž Smrkolj, Borut Gubina, Jure Bizjak, Kristina Kumer, Teja Fabjan, Joško Osredkar
BACKGROUND: The α-fetoprotein receptor (RECAF) is a proposed novel tumor marker for detecting several different types of tumors, including prostate cancer (PCa). OBJECTIVES: The aim of the study was to evaluate RECAF in discriminating benign prostatic conditions from PCa and to compare it with prostate-specific antigen (PSA). MATERIAL AND METHODS: A total of 64 patients with elevated serum PSA levels and/or abnormal digital rectal examination of the prostate referred to a tertiary center for transrectal ultrasound (TRUS) biopsy of the prostate were prospectively enrolled in the study from January 2009 to April 2010...
October 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29209551/synchronous-occurrence-of-primary-breast-carcinoma-and-primary-colon-adenocarcinoma
#7
Gurkan Yetkin, Fevzi Celayir, Ismail Ethem Akgun, Ramazan Ucak
A 65-year-old female patient presented to the emergency clinic with abdominal pain, meteorism, and intermittent rectal bleeding. Colonoscopy was performed, and a hepatic flexure tumor was detected. Histopathological examination of biopsy revealed adenocarcinoma. Thoracoabdominal CT was performed for staging, and a spiculated contour mass was found incidentally on the left breast. Mammography and ultrasonography were performed for the cause of these findings, and suspicious lesions of malignancy were seen in the left breast...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29207863/proper-treatment-option-for-small-rectal-neuroendocrine-tumors-using-precut-endoscopic-mucosal-resection
#8
Seun Ja Park
No abstract text is available yet for this article.
November 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29207857/diagnosis-and-management-of-rectal-neuroendocrine-tumors
#9
REVIEW
Shreya Chablaney, Zachary A Zator, Nikhil A Kumta
The incidence of rectal neuroendocrine tumors (NETs) has increased by almost ten-fold over the past 30 years. There has been a heightened awareness of the malignant potential of rectal NETs. Fortunately, many rectal NETs are discovered at earlier stages due to colon cancer screening programs. Endoscopic ultrasound is useful in assessing both residual tumor burden after retrospective diagnosis and tumor characteristics to help guide subsequent management. Current guidelines suggest endoscopic resection of rectal NETs ≤10 mm as a safe therapeutic option given their low risk of metastasis...
November 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29207718/an-alpha-fetoprotein-producing-gastric-tumor-with-yolk-sac-hepatoid-and-papillary-adenocarcinoma-components
#10
Archana Lakshmanan, Ann Kurian, Annapurneswari Subramanyan, Ayyappan Srinivasan
Alpha Fetoprotein (AFP) producing gastric carcinomas are very rare and have unique clinicopathological features and an extremely poor prognosis. Here, we report a case of AFP producing gastric carcinoma with three distinct histomorphologic patterns such as yolk sac like, hepatoid, tubular and papillary adenocarcinoma components. The uniqueness of this case is absence of metastases and associated findings such as fundic gland polyposis with varying degrees of dysplasia, gastric and duodenal well differentiated neuroendocrine tumour and rectal ganglioneuroma...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206996/tumor-regression-grading-after-preoperative-chemoradiotherapy-as-a-prognostic-factor-and-individual-level-surrogate-for-disease-free-survival-in-rectal-cancer
#11
Emmanouil Fokas, Philipp Ströbel, Rainer Fietkau, Michael Ghadimi, Torsten Liersch, Gerhard G Grabenbauer, Arndt Hartmann, Marco Kaufmann, Rolf Sauer, Ullrich Graeven, Hans Hoffmanns, Hans-Rudolf Raab, Torsten Hothorn, Christian Wittekind, Claus Rödel
Background: We investigated tumor regression grading (TRG) as a prognostic marker and individual-level surrogate for disease-free survival (DFS) in patients with rectal carcinoma treated within the Chirurgische Arbeitsgemeinschaft fur Onkologie/Arbeitsgemeinschaft Radiologische Onkologie/Arbeitsgemeinschaft Internistische Onkologie (CAO/ARO/AIO)-04 randomized trial. Methods: TRG was recorded prospectively using the Dworak classification in 1179 patients after preoperative fluorouracil-based chemoradiotherapy (CRT) with or without oxaliplatin...
December 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29205364/effects-of-local-multivisceral-resection-for-clinically-locally-advanced-rectal-cancer-on-long-term-outcomes
#12
Anne M Dinaux, Lieve G J Leijssen, Liliana G Bordeianou, Hiroko Kunitake, David L Berger
INTRODUCTION: Multivisceral resection is occasionally needed to obtain clear margins in patients with transmural rectal cancer. Most series demonstrate equivalent outcomes between those patients who undergo multivisceral resections and those who do not, provided an R0-resection is achieved. This study focuses solely on patients who received neoadjuvant treatment for clinically transmural rectal cancers and underwent a local multivisceral R0-resection. METHODS: A retrospective, single center analysis of consecutive series of patients who received a surgical R0-resection after neoadjuvant treatment for a clinically transmural, non-metastatic, primary rectal cancer...
December 4, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29204504/self-renewing-monolayer-of-primary-colonic-or-rectal-epithelial-cells
#13
Yuli Wang, Matthew DiSalvo, Dulan B Gunasekara, Johanna Dutton, Angela Proctor, Michael S Lebhar, Ian A Williamson, Jennifer Speer, Riley L Howard, Nicole M Smiddy, Scott J Bultman, Christopher E Sims, Scott T Magness, Nancy L Allbritton
Background & Aims: Three-dimensional organoid culture has fundamentally changed the in vitro study of intestinal biology enabling novel assays; however, its use is limited because of an inaccessible luminal compartment and challenges to data gathering in a three-dimensional hydrogel matrix. Long-lived, self-renewing 2-dimensional (2-D) tissue cultured from primary colon cells has not been accomplished. Methods: The surface matrix and chemical factors that sustain 2-D mouse colonic and human rectal epithelial cell monolayers with cell repertoires comparable to that in vivo were identified...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29203980/quality-of-life-after-total-mesorectal-excision-tme-for-rectal-carcinoma-a-study-from-a-tertiary-care-hospital-in-northern-india
#14
Rauf Ahmad Wani, Ikhlaq-Ul-Aziz Bhat, Fazl Qadir Parray, Nisar Ahmad Chowdri
Quality of life (QoL) is a key element in rectal cancer (RC) patients. There is not much data regarding this from North India. This study assesses QoL following low anterior resection (LAR) and abdominoperineal resection (APR), operated for low rectal tumors at a high-volume center in northern India. One-hundred-thirty patients of rectal carcinoma were prospectively assessed for quality of life using the European Organization for Cancer QLQ-30 and CR29 questionnaires and compared with reference data population...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203979/young-vs-old-colorectal-cancer-in-indian-subcontinent-a-tertiary-care-center-experience
#15
Ashish B Pokharkar, Manish Bhandare, Prachi Patil, Shaesta Mehta, Reena Engineer, Avanish P Saklani
This study aims to compare patient, tumor, treatment-related factors and survival between young (<45 years) and old (>45 years) Indian colorectal cancer (CRC) patients. Total 778 patients of CRC were registered at tertiary cancer center in India between 1 August 2013 and 31 July 2014. Patients were followed up for median period of 27.73 months. Data regarding patient, tumor, treatment and survival-related factors were collected. Patients were divided in young (≤45 years) and old (>45 years) age groups...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203978/colorectal-cancer-in-india-an-audit-from-a-tertiary-center-in-a-low-prevalence-area
#16
Prachi S Patil, Avanish Saklani, Pravir Gambhire, Shaesta Mehta, Reena Engineer, Ashwin De'Souza, Supriya Chopra, Munita Bal
Colorectal cancer (CRC) is a common cancer worldwide with a low reported incidence in India. There is significant geographical variation in the incidence rates, and the presentation may also vary. There are few studies evaluating the clinical profile of CRC in Indian patients. We analyzed a prospective database maintained at the Tata Memorial Hospital, a referral cancer center in Mumbai, of consecutive patients with CRC between August 2013 and August 2014. We captured details regarding the demography, symptoms, pathology, stage, and treatment plan...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203975/a-prospective-study-of-distal-microscopic-spread-in-rectal-cancer-after-neoadjuvant-chemoradiation-in-pinned-and-unpinned-specimen
#17
Aravind S Kapali, K Chandramohan, A V Jayasudha
The most important margin in determining the prognosis of rectal cancer is circumferential resection margin (CRM). But, the type of surgery is determined by distal rectal margin (DRM), whether sphincter saving procedure is possible or patient needs an abdominoperineal resection. There are no standardized uniform guidelines for measurement of DRM. The purpose of this study is to assess the distal microscopic spread beyond gross margin after neoadjuvant concurrent chemoradiation (CCRT) in rectal cancers, the factors influencing the distal microscopic spread, the shrinkage of the distal margin in pinned and unpinned fresh and fixed specimen, and to find out the best method of measurement of distal rectal margin...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203973/long-term-functional-and-oncological-outcomes-following-intersphincteric-resection-for-low-rectal-cancers
#18
Sivakumar Mahalingam, Ramakrishnan Ayloor Seshadri, Surendran Veeraiah
Surgery for low rectal cancer often involves a permanent stoma. Intersphincteric resection (ISR) with colo-anal anastomosis is a valuable sphincter sparing surgical procedure that avoids the need for permanent stoma in patients with low rectal cancer. The aim of this study was to analyze the long-term functional and oncological outcomes following ISR. This was a retrospective analysis of patients with low rectal cancer who underwent ISR with colo-anal anastomosis in our institution between 2007 and 2015. All patients had a diversion stoma...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29200872/lymphocyte-to-monocyte-ratio-before-chemoradiotherapy-represents-a-prognostic-predictor-for-locally-advanced-rectal-cancer
#19
Yu-Xiang Deng, Jun-Zhong Lin, Jian-Hong Peng, Yu-Jie Zhao, Qiao-Qi Sui, Xiao-Jun Wu, Zhen-Hai Lu, Yuan-Hong Gao, Zhi-Fang Zeng, Zhi-Zhong Pan
Research indicates that cancer-triggered inflammation plays a pivotal role in carcinogenesis. Here, we aimed to evaluate the correlation of lymphocyte-to-monocyte ratio (LMR) before neoadjuvant chemoradiotherapy (CRT) with clinical outcomes in patients with locally advanced rectal cancer (LARC). We retrospectively enrolled 317 consecutive patients with LARC between 2004 and 2013. The optimal cutoff values of LMR were determined using receiver operating curve analysis. Overall survival (OS) and disease-free survival related to the LMR were analyzed using the log-rank test and multivariate Cox regression methods...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29199720/a-prospective-randomized-trial-comparing-capecitabine-based-chemoradiotherapy-with-5-fu-based-chemoradiotherapy-in-neoadjuvant-setting-in-locally-advanced-carcinoma-rectum
#20
K Singh, M K Gupta, R K Seam, M Gupta
INTRODUCTION: Fluorouracil (FU)based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. Capecitabine is an oral fluoropyrimidine that generates 5FU preferentially at the tumor site by exploiting the higher activity of the enzyme thymidine phosphorylase in tumor tissue compared with healthy tissue. As an oral agent, capecitabine can be administered in the outpatient setting, potentially providing FU exposure similar to a lowdose continuous infusion of 5FU...
January 2017: Indian Journal of Cancer
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