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https://www.readbyqxmd.com/read/29053402/what-are-we-missing-false-negative-cancers-at-multiparametric-mr-imaging-of-the-prostate
#1
Samuel Borofsky, Arvin K George, Sonia Gaur, Marcelino Bernardo, Matthew D Greer, Francesca V Mertan, Myles Taffel, Vanesa Moreno, Maria J Merino, Bradford J Wood, Peter A Pinto, Peter L Choyke, Baris Turkbey
Purpose To characterize clinically important prostate cancers missed at multiparametric (MP) magnetic resonance (MR) imaging. Materials and Methods The local institutional review board approved this HIPAA-compliant retrospective single-center study, which included 100 consecutive patients who had undergone MP MR imaging and subsequent radical prostatectomy. A genitourinary pathologist blinded to MP MR findings outlined prostate cancers on whole-mount pathology slices. Two readers correlated mapped lesions with reports of prospectively read MP MR images...
October 20, 2017: Radiology
https://www.readbyqxmd.com/read/29052070/the-feasibility-of-laparoscopic-rectal-resection-in-patients-undergoing-reoperation-after-transanal-endoscopic-microsurgery-tem
#2
M Ortenzi, R Ghiselli, A Paolucci, M Guerrieri
BACKGROUND: The success of transanal endoscopic microsurgery (TEM) for early rectal cancer depends on proper indications and strict patient selection. When unfavorable pathologic features are identified after TEM operation, total mesorectal excision is recommended to minimize the risk of recurrence. In this study, data were collected in a retrospective series of patients to determine the results of laparoscopic reoperation after TEM. METHODS: All patients underwent an accurate rectal-digital examination and clinical tumor staging by transanal endosonography, CT, and/or MRI...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29048218/radiotherapy-for-patients-with-resected-tumor-deposit-positive-colorectal-cancer-a-surveillance-epidemiology-and-end-results-based-population-study
#3
Laxmi B Chavali, Adana A M Llanos, Jing-Ping Yun, Stephanie M Hill, Xiang-Lin Tan, Lanjing Zhang
CONTEXT: - According to the American Joint Committee on Cancer's Cancer Staging Manual, 7th edition, TNM classification, tumor deposit (TD)-positive colorectal cancers (CRCs) are classified as N1c. The effects of radiotherapy and the effects of the updated American Joint Committee on Cancer 7th edition TNM N1c classification for patients with TD-positive CRC are unclear. OBJECTIVE: - To investigate outcomes of radiotherapy in patients with resected TD-positive CRC...
October 19, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29047070/predictive-factors-for-lymph-node-metastasis-and-prognostic-factors-for-survival-in-rectal-neuroendocrine-tumors
#4
Beonghoon Sohn, Yoomin Kwon, Seung-Bum Ryoo, Inho Song, Yoon-Hye Kwon, Dong Woon Lee, Sang Hui Moon, Ji Won Park, Seung-Yong Jeong, Kyu Joo Park
INTRODUCTION: Neuroendocrine tumors have malignant potential, and lymph node metastasis can occur. This study aimed to identify predictive factors of lymph node metastasis and prognostic factors for survival in rectal neuroendocrine tumors. METHODS: Sixty-four patients underwent endoscopic or surgical treatment for rectal NET. The data on these patients were collected in our database prospectively and reviewed retrospectively. RESULTS: Transanal excision was performed in 28 (43...
October 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29046927/fdg-pet-ct-radiomics-for-predicting-the-outcome-of-locally-advanced-rectal-cancer
#5
Pierre Lovinfosse, Marc Polus, Daniel Van Daele, Philippe Martinive, Frédéric Daenen, Mathieu Hatt, Dimitris Visvikis, Benjamin Koopmansch, Frédéric Lambert, Carla Coimbra, Laurence Seidel, Adelin Albert, Philippe Delvenne, Roland Hustinx
PURPOSE: The aim of this study was to investigate the prognostic value of baseline (18)F-FDG PET/CT textural analysis in locally-advanced rectal cancer (LARC). METHODS: Eighty-six patients with LARC underwent (18)F-FDG PET/CT before treatment. Maximum and mean standard uptake values (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), histogram-intensity features, as well as 11 local and regional textural features, were evaluated...
October 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29046790/intraluminal-rectal-cancer-metastasis-to-the-small-bowel-an-extremely-rare-case-report
#6
Paraskevas Stamopoulos, Nikolaos Machairas, Stylianos Kykalos, Afrodite Nonni, Gregory Kouraklis, Georgios C Sotiropoulos
Prolonged survival in patients suffering from colorectal cancer (CRC) may lead to the emergence of rare metastatic sites that are not well-documented in the literature. We herein describe a very rare case of an intraluminal small intestinal metastasis in a patient with previously resected CRC. A 71-year-old Caucasian male patient with a history of rectosigmoid junction cancer was initially treated with anterior resection. The tumor was classified as pT3pN0 (0/26) M0, stage II. Eighteen months after the primary surgery, local recurrence was detected in the presacral region, and the patient received combined image-guided radiotherapy and chemotherapy...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29046789/a-retrospective-study-of-late-adverse-events-in-proton-beam-therapy-for-prostate-cancer
#7
Hirokazu Makishima, Hitoshi Ishikawa, Keiichi Tanaka, Yutaro Mori, Masashi Mizumoto, Kayoko Ohnishi, Teruhito Aihara, Nobuyoshi Fukumitsu, Toshiyuki Okumura, Hideyuki Sakurai
The efficacy and safety of proton beam therapy (PBT) were retrospectively evaluated in 111 consecutive patients with prostate cancer who underwent definitive PBT between 2008 and 2012. Following exclusion of 18 patients due to treatment suspension, loss to follow-up, and histology, the analysis included 93 patients with a median age of 68 years (range, 49-81 years). A total of 7, 32 and 54 prostate cancer patients were classified as low-, intermediate- and high-risk, respectively, as follows: High-risk, T≥3a or prostate-specific antigen (PSA) ≥20 ng/ml or Gleason Score ≥8; low-risk, T ≤2b and PSA≤10 ng/ml and Gleason Score=6; intermediate-risk, all other combinations...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29038720/epidemiology-of-senile-prostatic-enlargement-among-elderly-men-in-arar-kingdom-of-saudi-arabia
#8
Abdullah Barghash Alanazi, Anfal Muaddi Alshalan, Omar Ayed Alanazi, Munif Salah Alanazi, Abdulaziz Inad Alanazi, Abdullah Hussain Alanazi, Anwar Mohammed Alhadhari, Ahmed Saad Alanazi, Rahmah Abdulhadi Alanazi, Ibtisam Matan Alanazi, Mohammed Abdullah Alanazi, Mohammed Abdullah Alkhidhr, Hassan Ali Aldehneen, Raed Khalid Alanazi
BACKGROUND AND AIM: Senile prostatic enlargement due to benign prostatic hyperplasia (BPH) is a common problem among older men, and is responsible for considerable disability. This study was conducted to determine the prevalence and determinants of the clinically diagnosed prostatic enlargement among elderly men in Arar, Northern Saudi Arabia. METHODS: This cross-sectional study was carried out on all consented elderly males attending the outpatient clinic of the urology department of Arar Central Hospital from February 2017 to July 30, 2017...
September 2017: Electronic Physician
https://www.readbyqxmd.com/read/29038297/tumor-pdcd1lg2-pd-l2-expression-and-the-lymphocytic-reaction-to-colorectal-cancer
#9
Yohei Masugi, Reiko Nishihara, Tsuyoshi Hamada, Mingyang Song, Annacarolina da Silva, Keisuke Kosumi, Mancang Gu, Yan Shi, Wanwan Li, Li Liu, Daniel Nevo, Kentaro Inamura, Yin Cao, Xiaoyun Liao, Katsuhiko Nosho, Andrew T Chan, Marios Giannakis, Adam J Bass, F Stephen Hodi, Gordon J Freeman, Scott J Rodig, Charles S Fuchs, Zhi Rong Qian, Jonathan A Nowak, Shuji Ogino
Expression of the immune-checkpoint ligand CD274 (programmed cell death 1 ligand 1, PD-L1, from gene CD274) contributes to suppression of antitumor T cell-mediated immune response in various tumor types. However, the role of PDCD1LG2 (PD-L2, CD273, from gene PDCD1LG2) in the tumor microenvironment remains unclear. We hypothesized that tumor PDCD1LG2 expression might be inversely associated with lymphocytic reactions to colorectal cancer. We examined tumor PDCD1LG2 expression by immunohistochemistry in 823 colon and rectal carcinoma cases within two U...
October 16, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/29037218/clinicopathologic-features-and-treatment-efficacy-of-chinese-patients-with-braf-mutated-metastatic-colorectal-cancer-a-retrospective-observational-study
#10
Xicheng Wang, Qing Wei, Jing Gao, Jian Li, Jie Li, Jifang Gong, Yanyan Li, Lin Shen
BACKGROUND: The prognostic role of the V600E mutation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) in metastatic colorectal cancer (mCRC) is well established, but the therapeutic regimen targeting this disease is lacking. This study aimed to analyze the clinicopathologic features of and treatment efficacy of commonly used regimens on BRAF-mutated mCRCs. METHODS: We collected and reviewed the medical records of mCRC patients treated at Peking University Cancer Hospital & Institute (Beijing, China) between July 2011 and July 2016...
October 16, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29037023/simultaneous-integrated-boost-intensity-modulated-radiotherapy-versus-3-dimensional-conformal-radiotherapy-in-preoperative-concurrent-chemoradiotherapy-for-locally-advanced-rectal-cancer
#11
Bong Kyung Bae, Min Kyu Kang, Jae-Chul Kim, Mi Young Kim, Gyu-Seog Choi, Jong Gwang Kim, Byung Woog Kang, Hye Jin Kim, Soo Yeun Park
PURPOSE: To evaluate the feasibility of simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) for preoperative concurrent chemoradiotherapy (PCRT) in locally advanced rectal cancer (LARC), by comparing with 3-dimensional conformal radiotherapy (3D-CRT). MATERIALS AND METHODS: Patients who were treated with PCRT for LARC from 2015 January to 2016 December were retrospectively enrolled. Total doses of 45 Gy to 50.4 Gy with 3D-CRT or SIB-IMRT were administered concomitantly with 5-fluorouracil plus leucovorin or capecitabine...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29037019/effect-of-leukocyte-alteration-on-treatment-outcomes-following-preoperative-chemoradiotherapy-in-patients-with-rectal-cancer
#12
Tae Gyu Kim, Won Park, Doo Ho Choi, Hee Chul Park, Seok-Hyung Kim, Yong Beom Cho, Seong Hyen Yun, Hee Cheol Kim, Woo Yong Lee, Jeeyun Lee, Joon Oh Park, Young Suk Park
PURPOSE: Hematotoxicity following anti-cancer treatment is known to be related to treatment efficacy in several malignancies. The purpose of this study was to examine the hematologic parameters related to the tumor response and survival in patients treated with curative surgery following preoperative chemoradiotherapy (CRT) for rectal cancer. MATERIALS AND METHODS: Four hundred eighteen patients with rectal cancer who underwent preoperative CRT and curative surgery were analyzed, retrospectively...
September 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29032763/basics-in-endoscopic-ultrasound-part-1-diagnostic-indications-and-tissue-sampling
#13
Marta Serrani, Claudio Calvanese, Andrea Lisotti, Giancarlo Caletti, Ludovico Abenavoli, Pietro Fusaroli
BACKGROUND: Endoscopic ultrasound has been used in the clinical arena for almost 35 years and it is now well-integrated in everyday hospital practice. METHOD: We conducted a systematic review of the available English-language articles. OBJECTIVE: The purpose of this review is to summarize all the relevant indications to endoscopic ultrasound and analyze its relevant data in terms of accuracy and clinical outcomes. RESULTS: More than 5000 scientific papers published in the literature have demonstrated its high accuracy for the diagnosis and staging of a variety of benign and malignant conditions...
October 9, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29030683/preoperative-alkaline-phosphatase-elevation-was-associated-with-poor-survival-in-colorectal-cancer-patients
#14
Hsin-Yuan Hung, Jinn-Shiun Chen, Chien-YuhYeh, Reiping Tang, Pao-Shiu Hsieh, Wen-SyTasi, Yau-Tong You, Jeng-Fu You, Jy-Ming Chiang
PURPOSE: Purpose To assess preoperative serum alkaline phosphatase (ALP) levels in colon adenocarcinomapatients with various clinical features and determine its prognostic value. METHODS: Between 2000 and 2013, 10,800 stage I-IV colon cancer patients who underwent surgery wereretrospectively enrolled. The relationship between ALP level and variables, including age, gender,carcinoembryonic Antigen (CEA) levels, aspartate aminotransferase (AST) level, bilirubin level, tumor size,liver cirrhosis, hepatitis, albumin level, histological type, and TNM-stage, were evaluated...
October 13, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29029440/colorectal-carcinoma-with-osseous-metaplasia
#15
Xibo Liu, Jinghong Xu, Lirong Chen
Osseous metaplasia (OM) is rarely observed in colorectal cancer (incidence < 0.4% in rectal cancer), where it has a non-specific clinical presentation and unknown pathogenesis. Here, we report three cases of colorectal carcinoma with OM and propose a new hypothesis. All three patients (two males and one female) were Chinese and had different sites of colorectal carcinoma with OM: rectum, sigmoid colon, and appendix. The pathologic diagnoses were serrated adenocarcinoma; moderately to poorly differentiated adenocarcinoma with micropapillary carcinoma and cribriform comedo-type adenocarcinoma; and mucinous adenocarcinoma, respectively...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#16
REVIEW
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29025530/intensive-follow-up-after-curative-surgery-for-colorectal-cancer
#17
Rita Vale Rodrigues, João Pereira da Silva, Isadora Rosa, Isabel Santos, Nuno Pereira, Carla Soares, António Dias Pereira
INTRODUCTION: The purpose of postoperative surveillance programs after curative treatment for colorectal cancer is to detect asymptomatic recurrences with the premise that an important rate will be eligible for curative resection, improving overall survival. We have implemented a surveillance program for patients with colorectal cancer, stages II-III, with periodic clinical, carcinoembryonic antigen and cancer antigen-19-9 assessment, computed tomography and colonoscopy. The aim of this study was to assess the rate of curative treatment of recurrence, colorectal cancer mortality and clinical characteristics associated with non-resectable recurrence...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29020763/efficacy-of-precut-endoscopic-mucosal-resection-for-treatment-of-rectal-neuroendocrine-tumors
#18
Hoonsub So, Su Hyun Yoo, Seungbong Han, Gwang-Un Kim, Myeongsook Seo, Sung Wook Hwang, Dong-Hoon Yang, Jeong-Sik Byeon
Background/Aims: Endoscopic resection is the first-line treatment for rectal neuroendocrine tumors (NETs) measuring <1 cm and those between 1 and 2 cm in size. However, conventional endoscopic resection cannot achieve complete resection in all cases. We aimed to analyze clinical outcomes of precut endoscopic mucosal resection (EMR-P) used for the management of rectal NET. Methods: EMR-P was used to treat rectal NET in 72 patients at a single tertiary center between 2011 and 2015...
October 12, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/29019178/second-harmonic-generation-for-collagen-i-characterization-in-rectal-cancer-patients-with-and-without-preoperative-radiotherapy
#19
Stéphanie Blockhuys, Nisha Rani Agarwal, Camilla Hildesjö, Ingvar Jarlsfelt, Pernilla Wittung-Stafshede, Xiao-Feng Sun
Rectal cancer is treated with preoperative radiotherapy (RT) to downstage the tumor, reduce local recurrence, and improve patient survival. Still, the treatment outcome varies significantly and new biomarkers are desired. Collagen I (Col-I) is a potential biomarker, which can be visualized label-free by second harmonic generation (SHG). Here, we used SHG to identify Col-I changes induced by RT in surgical tissue, with the aim to evaluate the clinical significance of RT-induced Col-I changes. First, we established a procedure for quantitative evaluation of Col-I by SHG in CDX2-stained tissue sections...
October 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28994324/self-assembling-ha-pei-dsrna-p21-ternary-complexes-for-cd44-mediated-small-active-rna-delivery-to-colorectal-cancer
#20
Chen-Lin Feng, Yan-Xing Han, Hui-Hui Guo, Xiao-Lei Ma, Zhi-Qiang Wang, Lu-Lu Wang, Wen-Sheng Zheng, Jian-Dong Jiang
Our previous work proved that sequence specific double strand RNA (dsRNA-p21) effectively activated p21 gene expression of colorectal cancer (CRC) cells and consequently suppressed CRC growth. However, efficient delivery system is a significant challenge to achieve sufficient therapy. In this study, a self-assembled HA/PEI/dsRNA-p21 ternary complex (TC-dsRNA-p21) was developed for the tumor-target delivery of dsRNA-p21 into CRC cells. Hyaluronic acid (HA) was introduced to shield the PEI/dsRNA-p21 binary complexes (BC-dsRNA-p21) for reducing the cytotoxicity of PEI and for increasing the tumor-targeted intracellular uptake by cancer cells through HA-CD44 mediated endocytosis...
November 2017: Drug Delivery
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