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https://www.readbyqxmd.com/read/28526604/extramural-perineural-invasion-in-pt3-and-pt4-rectal-adenocarcinoma-as-prognostic-factor-after-preoperative-chemoradiotherapy
#1
Leonardo S Lino-Silva, Rosa A Salcedo-Hernández, Alejandro España-Ferrufino, Erika B Ruiz-García, Miguel Ruiz-Campos, Alberto M León-Takahashi, Abelardo Meneses-García
Perineural invasion (PNI) is widely studied in malignant tumors, and its prognostic significance is well demonstrated in the head and neck and prostate carcinomas, but its significance in rectal cancer is controversial. Most studies have focused on evaluating mural PNI (mPNI); however, extramural PNI (ePNI) may influence the prognosis after rectal cancer resection. We evaluated the prognostic value of ePNI compared with mPNI and with non-PNI, in rectal resections after preoperative chemoradiotherapy in 148 patients with pT3 and pT4 rectal carcinomas...
May 16, 2017: Human Pathology
https://www.readbyqxmd.com/read/28523473/young-colorectal-cancer-patients-often-present-too-late
#2
Jia-Hao Law, Frederick H Koh, Ker-Kan Tan
PURPOSE: Current screening and health education strategies on colorectal cancer (CRC) remain focused on individuals >50 years old. However, CRC in young adults is not uncommon. This paper aims to explore how CRC presents in young adults and their clinical outcomes. METHODS: All patients aged <50 years diagnosed with CRC from January 2007 to December 2015 were reviewed. Patient demographics, clinical symptoms, and outcomes of treatment were collected. RESULTS: Of 1367 patients diagnosed with CRC, 154 (11...
May 18, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28522950/red-flag-symptoms-detailed-account-of-clinicopathological-features-in-young-onset-colorectal-cancer
#3
Ramish Riaz, Nosheen Masood, Arfa Benish
BACKGROUND/AIMS: Colorectal cancer has long been considered disease of the West, typically occurring in old age; however, the incidence is rising in Asia. The pattern of disease is quite different in Asia, occurring at a younger age and at an advanced stage. Recognition of disease at an early stage is still a challenge for physicians. Few data are available regarding young-onset colorectal cancer in Pakistan. We conducted this study to fill this gap and provide deeper insight into clinical symptoms and histopathological features of young-onset colorectal cancer...
April 2017: Intestinal Research
https://www.readbyqxmd.com/read/28522902/non-invasive-evaluation-of-intestinal-disorders-the-role-of-elastographic-techniques
#4
REVIEW
Federica Branchi, Flavio Caprioli, Stefania Orlando, Dario Conte, Mirella Fraquelli
Over the recent years the non-invasive techniques for the evaluation of the small bowel have been playing a major role in the management of chronic intestinal diseases, such as inflammatory bowel diseases (IBD). The diagnostic performances of magnetic resonance imaging, computed tomography and ultrasound in the field of small bowel disorders, have been assessed and established for more than two decades. Newer sonographic techniques, such as strain elastography and shear wave elastography, have been put forward for the assessment of disease activity and characterization of IBD-related damage in the setting of Crohn's disease and other gastrointestinal disorders...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28521759/dosimetric-comparison-of-interstitial-brachytherapy-with-multi-channel-vaginal-cylinder-plans-in-patients-with-vaginal-tumors
#5
Lucas C Mendez, Moti Paudel, Matt Wronski, Ananth Ravi, Lisa Barbera, Eric Leung
BACKGROUND: To evaluate the dosimetric performance of multi-channel vaginal cylinder (MCVC) against interstitial brachytherapy (ISBT) for the treatment of vaginal tumors. METHODS: Vaginal tumors with extension of > 0.5 cm and ≤ 2 cm from the lateral vaginal wall and/or ≤ 1 cm in height above the vaginal vault were retrospectively selected from a ISBT registry trial database. The selected patients were treated with ISBT and targets included the intermediate (IRCTV) or high-risk (HRCTV) clinical target volumes...
May 18, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28521466/extranodal-marginal-zone-lymphoma-of-the-uterine-cervix-with-concomitant-copy-number-gains-of-the-malt1-and-bcl2-genes-a-case-report
#6
Tomoko Takimoto, Saori Maegawa, Hiroshi Tatsumi, Hisao Nagoshi, Yoshiaki Chinen, Yuji Shimura, Tsutomu Kobayashi, Shigeo Horiike, Shigeo Nakamura, Jo Kitawaki, Junya Kuroda, Masafumi Taniwaki
Extranodal marginal zone lymphoma (EMZL) of mucosa-associated lymphoid tissue (MALT) of the uterus is rare, and the etiology, pathophysiology and cytogenetic features remain unknown at present. The present study reports a case of a 71-year-old female with EMZL of the uterine cervix that was 80 mm in diameter and invaded directly into the rectal serosa. Complete remission was successfully induced by 6 courses of immunochemotherapy with rituximab plus cyclophosphamide, doxorubicin, vincristine and prednisolone...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28520513/rectal-mucinous-adenocarcinoma-mr-imaging-assessment-of-response-to-concurrent-chemotherapy-and-radiation-therapy-a-hypothesis-generating-study
#7
Seung Hyun Park, Joon Seok Lim, Jinae Lee, Ha Yan Kim, Woong Sub Koom, Hyuk Hur, Mi-Suk Park, Myeong-Jin Kim, Honsoul Kim
Purpose To develop a system for assessment of tumor regression grade (TRG) with magnetic resonance (MR) imaging that is applicable to rectal mucinous adenocarcinoma (RMAC) and to obtain a preliminary evaluation of the association of MR imaging assessment of TRG with response to preoperative concurrent chemotherapy and radiation therapy (CCRT). Materials and Methods This retrospective study was approved by the institutional review board, and informed consent was waived. Pre- and post-CCRT MR images of 59 patients with RMAC (median age, 59 years; range, 29-80 years; 42 men [median age, 59 years; range, 36-80 years] and 17 women [median age, 57 years; range, 29-79 years]) who underwent CCRT and subsequent elective resection from July 2005 to June 2015 were analyzed...
May 18, 2017: Radiology
https://www.readbyqxmd.com/read/28514887/transanal-inspection-and-management-of-low-colorectal-anastomosis-performed-with-a-new-technique-the-ticrant-study
#8
Francesco Crafa, Sebastian Smolarek, Giulia Missori, Mostafa Shalaby, Silvia Quareisma, Adele Noviello, Diletta Cassini, Pasquale Ascenzi, Luana Franceschilli, Paolo Delrio, Giannandrea Baldazzi, Ucchino Giampiero, Jacques Megevand, Giovanni Maria Romano, Pierpaolo Sileri
BACKGROUND: Anastomotic leakage is one of the most serious complications after rectal cancer surgery. METHOD: A prospective multicenter interventional study to assess a newly described technique of creating the colorectal and coloanal anastomosis. The primary outcome was to access the safety and efficacy of this technique in the reduction of anastomotic leak. RESULT: Fifty-three patients with rectal cancer who underwent low or ultra-low anterior resection were included in the study...
May 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28514763/the-value-of-diffusion-kurtosis-imaging-in-assessing-pathological-complete-response-to-neoadjuvant-chemoradiation-therapy-in-rectal-cancer-a-comparison-with-conventional-diffusion-weighted-imaging
#9
Feixiang Hu, Wei Tang, Yiqun Sun, Dang Wan, Sanjun Cai, Zhen Zhang, Robert Grimm, Xu Yan, Caixia Fu, Tong Tong, Weijun Peng
OBJECTIVES: The aim of this study is to comprehensively evaluate the advantage of diffusion kurtosis imaging (DKI) in distinguishing pathological complete response (pCR) from non-pCR patients with locally advanced rectal cancer (LARC) after neoadjuvant chemoradiation therapy (CRT) in comparison to conventional diffusion-weighted imaging (DWI). MATERIAL AND METHODS: Fifty-six consecutive patients diagnosed with LARC were prospectively enrolled and underwent pre- and post-CRT MRI on a 3...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28510098/body-mass-index-and-risk-of-colorectal-carcinoma-subtypes-classified-by-tumor-differentiation-status
#10
Akiko Hanyuda, Yin Cao, Tsuyoshi Hamada, Jonathan A Nowak, Zhi Rong Qian, Yohei Masugi, Annacarolina da Silva, Li Liu, Keisuke Kosumi, Thing Rinda Soong, Iny Jhun, Kana Wu, Xuehong Zhang, Mingyang Song, Jeffrey A Meyerhardt, Andrew T Chan, Charles S Fuchs, Edward L Giovannucci, Shuji Ogino, Reiko Nishihara
Previous studies suggest that abnormal energy balance status may dysregulate intestinal epithelial homeostasis and promote colorectal carcinogenesis, yet little is known about how host energy balance and obesity influence enterocyte differentiation during carcinogenesis. We hypothesized that the association between high body mass index (BMI) and colorectal carcinoma incidence might differ according to tumor histopathologic differentiation status. Using databases of the Nurses' Health Study and Health Professionals Follow-up Study, and duplication-method Cox proportional hazards models, we prospectively examined an association between BMI and the incidence of colorectal carcinoma subtypes classified by differentiation features...
May 16, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28507455/neoadjuvant-chemoradiotherapy-of-the-rectal-carcinoma-the-correlation-between-the-findings-on-the-restaging-multiparametric-3t-mri-scanning-and-the-surgical-findings
#11
Radovan Vojtíšek, Eva Korčáková, Jan Mařan, Ondřej Šorejs, Jindřich Fínek
AIM: To figure out how to correlate the findings on functional MRI and carried out after neoadjuvant CRT of rectal carcinoma with final histology after surgery. BACKGROUND: Neoadjuvant CRT is the standard treatment of locally advanced rectal carcinoma. Its use leads to the downstaging of the disease and in 15-42% of patients even to the detection of pCR after TME. The use of functional MRI improves the sensitivity and specificity of pCR detection up to 52-64% and 89-98%, respectively...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28503517/prognostic-significance-of-mucinous-histologic-subtype-on-oncologic-outcomes-in-patients-with-colorectal-cancer
#12
Sare Hosseini, Ali Mohammad Bananzadeh, Roham Salek, Mohammad Zare-Bandamiri, Ali Taghizadeh Kermani, Mohammad Mohammadianpanah
PURPOSE: Mucinous adenocarcinomas account for about 10% of all colorectal cancers. This study aimed to investigate the prognostic impact of mucinous histologic subtype on oncologic outcomes in patients with colorectal cancer. METHODS: This retrospective study was performed at two large tertiary university hospitals. We analyzed the characteristics, prognostic factors, and survival of patients with colorectal cancer who were treated and followed up between 2000 and 2013...
April 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28502883/comparative-evaluation-of-colonoscopy-assisted-transanal-minimally-invasive-surgery-via-glove-port-and-endoscopic-submucosal-dissection-for-early-rectal-tumor
#13
Weiming Mao, Xiujun Liao, Shuxian Shao, Wenjing Wu, Yanyan Yu, Guangen Yang
BACKGROUND: Early rectal tumor is usually managed by local excision. A novel method-colonoscopy-assisted transanal minimally invasive surgery via glove port (CA-TAMIS-GP)-for resecting early rectal tumor was developed and compared with endoscopic submucosal dissection (ESD). MATERIALS AND METHODS: We performed CA-TAMIS-GP surgery on 26 patients from January 2014 to February 2016. For better analysis, we retrospectively collected data from 31 patients who underwent ESD between October 2012 and December 2013; overall, 57 patients diagnosed with early rectal tumor were included in this study...
May 11, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28501970/cancer-center-volume-and-type-impact-stage-specific-utilization-of-neoadjuvant-therapy-in-rectal-cancer
#14
Emily F Midura, Andrew D Jung, Meghan C Daly, Dennis J Hanseman, Bradley R Davis, Shimul A Shah, Ian M Paquette
BACKGROUND: Neoadjuvant chemoradiation reduces local recurrence in locally advanced rectal cancer, and adherence to national and societal recommendations remains unknown. OBJECTIVE: To determine variability in guideline adherence in rectal cancer treatment and investigate whether hospital volume correlated with variability seen. DESIGN: We performed a retrospective analysis using the National Cancer Database rectal cancer participant user files from 2005 to 2010...
May 13, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28501248/local-excision-of-rectal-cancer
#15
REVIEW
Daniel Owen Young, Anjali S Kumar
Local excision (LE) of early-stage rectal cancer avoids the morbidity associated with radical surgery but has historically been associated with inferior oncologic outcomes. Newer techniques, including transanal endoscopic microsurgery (TEM) and transanal minimally invasive surgery (TAMIS), have been developed to improve the quality of LE and extend the benefits of LE to tumors in the more proximal rectum. This article provides an overview of conventional LE, TEM, and TAMIS techniques, including indications for their use and pertinent literature on their associated outcomes for rectal cancer...
June 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/28498471/sodium-tanshinone-iia-sulfonate-improves-inflammation-aortic-endothelial-cell-apoptosis-disseminated-intravascular-coagulation-and-multiple-organ-damage-in-a-rat-heat-stroke-model
#16
Fang Chen, Huimin Li, Guoguo Zhu, Xiaojuan Chen, Zhongzhi Tang
The aim of the present study was to investigate the effects of sodium tanshinone IIA sulfonate (STS) on inflammatory responses, aortic endothelial cell apoptosis, disseminated intravascular coagulation (DIC) and multiple organ damage in an animal model of classic heat stroke (CHS). The rats in the heat stroke (HS) and STS‑treated heat stroke (STS‑HS) groups were placed into a pre‑warmed animal temperature controller (ATC) at 35˚C. The moment at which the rectal temperature reached 43.5˚C was considered as the time of onset of HS...
May 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28498361/rectal-cancer-in-a-patient-with-bartter-syndrome-a-case-report
#17
Shiki Fujino, Norikatsu Miyoshi, Masayuki Ohue, Mikio Mukai, Yoji Kukita, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Yuichiro Doki, Masaki Mori
A woman with rectal cancer was scheduled for surgery. However, she also had hypokalemia, hyperreninemia, and hyperaldosteronism in the absence of any known predisposing factors or endocrine tumors. She was given intravenous potassium, and her blood abnormalities stabilized after tumor resection. Genetic analysis revealed mutations in several genes associated with Bartter syndrome (BS) and Gitelman syndrome, including SLC12A1, CLCNKB, CASR, SLC26A3, and SLC12A3. Prostaglandin E2 (PGE2) plays an important role in BS and worsens electrolyte abnormalities...
May 12, 2017: Genes
https://www.readbyqxmd.com/read/28497403/locally-advanced-rectal-cancer-predicting-non-responders-to-neoadjuvant-chemoradiotherapy-using-apparent-diffusion-coefficient-textures
#18
Ming Liu, Han Lv, Li-Heng Liu, Zheng-Han Yang, Er-Hu Jin, Zhen-Chang Wang
PURPOSE: The purpose of the study is to evaluate whether apparent diffusion coefficient (ADC) textures could identify patient with locally advanced rectal cancer (LARC) who would not respond to neoadjuvant chemoradiotherapy (NCRT). METHOD: Twenty-six patients who underwent MRI including diffusion-weighted imaging at a 3.0 T system before NCRT were enrolled. Texture analysis of pre-therapy ADC mapping was carried out, and a total of 133 ADC textures as well as routine mean ADC value of the primary tumor were extracted for each patient...
May 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28497402/impact-of-resection-versus-no-resection-of-the-primary-tumor-on-survival-in-patients-with-colorectal-cancer-and-synchronous-unresectable-metastases-protocol-for-a-randomized-multicenter-study-cr4
#19
Sebastiano Biondo, Ricardo Frago, Esther Kreisler, Eloy Espin-Basany
PURPOSE: The purpose of this study was to determine whether patients diagnosed with colorectal cancer and synchronous unresectable metastases (stage IV) can benefit from resection of the primary tumor in terms of an improvement in cancer-specific survival. METHODS: Stage IV colorectal cancer patients are eligible for inclusion in a randomized multicenter study carried out in 18 hospitals throughout Spain. Exclusion criteria are rectal tumors below 12 cm from the anal verge or locally advanced tumors, multiple bone or central nervous system metastases, and history of another primary cancer...
May 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28495148/analysis-of-urinary-psa-glycosylation-is-not-indicative-of-high-risk-prostate-cancer
#20
Sílvia Barrabés, Esther Llop, Montserrat Ferrer-Batallé, Manel Ramírez, Rosa N Aleixandre, Antoinette S Perry, Rafael de Llorens, Rosa Peracaula
The levels of core fucosylation and α2,3-linked sialic acid in serum Prostate Specific Antigen (PSA), using the lectins Pholiota squarrosa lectin (PhoSL) and Sambucus nigra agglutinin (SNA), can discriminate between Benign Prostatic Hyperplasia (BPH) and indolent prostate cancer (PCa) from aggressive PCa. In the present work we evaluated whether these glycosylation determinants could also be altered in urinary PSA obtained after digital rectal examination (DRE) and could also be useful for diagnosis determinations...
May 8, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
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