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https://www.readbyqxmd.com/read/28938451/antibody-mediated-targeting-of-the-fgfr1c-isoform-increases-glucose-uptake-in-white-and-brown-adipose-tissue-in-male-mice
#1
Jo E Lewis, Ricardo J Samms, Scott Cooper, Jeni C Luckett, Alan C Perkins, James D Dunbar, Dennis P Smith, Paul J Emmerson, Andrew C Adams, Francis J P Ebling, Kostas Tsintzas
The increased prevalence of obesity and its cardiometabolic implications demonstrates the imperative to identify novel therapeutic targets able to effect meaningful metabolic changes in this population. Antibody-mediated targeting of fibroblast growth factor receptor 1c isoform (FGFR1c) has been shown to ameliorate hyperglycaemia and protect from diet- and genetically-induced obesity in rodents and non-human primates. However, it is currently unknown which tissue(s) contribute to this glucose lowering effect...
August 16, 2017: Endocrinology
https://www.readbyqxmd.com/read/28932757/a-five-repeat-micro-dystrophin-gene-ameliorated-dystrophic-phenotype-in-the-severe-dba-2j-mdx-model-of-duchenne-muscular-dystrophy
#2
Chady H Hakim, Nalinda B Wasala, Xiufang Pan, Kasun Kodippili, Yongping Yue, Keqing Zhang, Gang Yao, Brittney Haffner, Sean X Duan, Julian Ramos, Joel S Schneider, N Nora Yang, Jeffrey S Chamberlain, Dongsheng Duan
Micro-dystrophins are highly promising candidates for treating Duchenne muscular dystrophy, a lethal muscle disease caused by dystrophin deficiency. Here, we report robust disease rescue in the severe DBA/2J-mdx model with a neuronal nitric oxide synthase (nNOS)-binding micro-dystrophin vector. 2 × 10(13) vector genome particles/mouse of the vector were delivered intravenously to 10-week-old mice and were evaluated at 6 months of age. Saturated micro-dystrophin expression was detected in all skeletal muscles and the heart and restored the dystrophin-associated glycoprotein complex and nNOS...
September 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28932004/effects-of-pulsed-therapeutic-ultrasound-on-the-treatment-of-people-with-knee-osteoarthritis
#3
Eliana-Isabel Rodríguez-Grande, Jose-Luis Osma-Rueda, Yannely Serrano-Villar, Carolina Ramírez
[Purpose] The aim was to evaluate the effect of therapeutic ultrasound on the pain, joint mobility, muscle strength, physical function, and quality of life of people with knee OA. [Subjects and Methods] One-site, one-arm, before-after study that included people with Grade II or III tibiofemoral osteoarthritis. Ten therapeutic ultrasound sessions (duty cycle=20%, ERA=10 cm(2), BNR=6:1, SATP=2.2 W/cm(2), SATA=0.44 W/cm(2), frequency=1 MHz, time=4 minutes) were applied. Assessments of primary outcome variables: pain intensity and function, and secondary variables: joint mobility, muscle strength and quality of life, were performed at onset and end of therapy; an additional intermediate evaluation was included for the primary variables...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28929434/random-electromyostimulation-promotes-osteogenesis-and-the-mechanical-properties-of-rat-bones
#4
Shigeo M Tanaka, Yuma Yorozuya, Daisuke Takatsu
Exercise is often recommended as a promising non-pharmacologic countermeasure to prevent osteoporosis. However, elderly osteoporotic patients generally have physical fitness difficulties preventing them from performing effective and sustainable exercise. Electromyostimulation should be one effective modality for non-pharmacological prevention of osteoporosis without any voluntary physical movements. However, successful stimulation patterns remain controversial. As suggested by our previous in vitro studies, randomized timing of stimulation could be a candidate to maximize the osteogenic effect of electromyostimulation...
September 19, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28919733/cycle-ergometer-and-inspiratory-muscle-training-offer-modest-benefit-compared-with-cycle-ergometer-alone-a-comprehensive-assessment-in-stable-copd-patients
#5
Kai Wang, Guang-Qiao Zeng, Rui Li, Yu-Wen Luo, Mei Wang, Yu-He Hu, Wen-Hui Xu, Lu-Qian Zhou, Rong-Chang Chen, Xin Chen
BACKGROUND: Cycle ergometer training (CET) has been shown to improve exercise performance of the quadriceps muscles in patients with COPD, and inspiratory muscle training (IMT) may improve the pressure-generating capacity of the inspiratory muscles. However, the effects of combined CET and IMT remain unclear and there is a lack of comprehensive assessment. MATERIALS AND METHODS: Eighty-one patients with COPD were randomly allocated to three groups: 28 received 8 weeks of CET + IMT (combined training group), 27 received 8 weeks of CET alone (CET group), and 26 only received 8 weeks of free walking (control group)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28918506/young-athletes-after-acl-reconstruction-with-quadriceps-strength-asymmetry-at-the-time-of-return-to-sport-demonstrate-decreased-knee-function-1%C3%A2-year-later
#6
Matthew P Ithurburn, Alex R Altenburger, Staci Thomas, Timothy E Hewett, Mark V Paterno, Laura C Schmitt
PURPOSE: Quadriceps femoris (QF) strength deficits at return-to-sport (RTS) after ACL reconstruction (ACLR) contribute to decreased knee function at the same time point. However, the impact of QF strength at RTS on longitudinal function has not been examined. The purpose of this study was to test the hypothesis that young athletes after ACLR with QF strength asymmetry at RTS would demonstrate decreased knee-related function and lower proportions of functional recovery at 1 year post-RTS compared to young athletes following ACLR with nearly symmetric QF strength at RTS...
September 16, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28916871/strength-and-functional-symmetry-is-associated-with-post-operative-rehabilitation-in-patients-following-anterior-cruciate-ligament-reconstruction
#7
Jay R Ebert, Peter Edwards, Luke Yi, Brendan Joss, Timothy Ackland, Richard Carey-Smith, Jens-Ulrich Buelow, Ben Hewitt
PURPOSE: To investigate strength and functional symmetry during common tests in patients after anterior cruciate ligament reconstruction (ACLR), and its association with post-operative rehabilitation. METHODS: At a median 11.0 months post-surgery (range 10-14), 111 ACLR patients were assessed. A rehabilitation grading tool was employed to evaluate the duration and supervision of rehabilitation, as well as whether structured jumping, landing and agility exercises were undertaken...
September 15, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28916482/disposition-of-treosulfan-and-its-active-monoepoxide-in-a-bone-marrow-liver-lungs-brain-and-muscle-studies-in-a-rat-model-with-clinical-relevance
#8
Michał Romański, Anna Kasprzyk, Mateusz Walczak, Agnieszka Ziółkowska, Franciszek Główka
For the recent years, the application of treosulfan (TREO)-based conditioning prior to hematopoietic stem cell transplantation (HSCT) has been increasing as an alternative to busulfan-based therapy, especially for patients presenting high risk of developing hepato-, pulmo-, and neurotoxicity. So far, the penetration of TREO and its epoxy-derivatives into central nervous system and aqueous humor of the eye has been investigated. However, lacking knowledge on the compounds distribution into the other key tissues precludes comprehensive understanding and assessment of TREO clinical efficacy and toxicity...
September 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28913921/analgesic-efficacy-of-local-infiltration-analgesia-vs-femoral-nerve-block-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-and-meta-analysis
#9
REVIEW
K R Kirkham, S Grape, R Martin, E Albrecht
Many published reports consider blockade of the femoral nerve distribution the best available analgesic treatment after anterior cruciate ligament reconstruction. However, some argue that an alternative approach of infiltrating local anaesthetic into the surgical site has similar efficacy. The objectives of this meta-analysis were to compare the analgesic and functional outcomes of both treatments following anterior ligament reconstruction. The primary outcomes were pain scores at rest (analogue scale, 0-10) in the early (0-2 postoperative hours), intermediate (3-12 hours) and late postoperative periods (13-24 hours)...
September 15, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28911291/administration-of-anaesthetic-triggering-agents-to-patients-tested-malignant-hyperthermia-normal-and-their-relatives-in-new-zealand-an-update
#10
D Frei, K M Stowell, E E Langton, L McRedmond, N A Pollock, T F Bulger
Testing for malignant hyperthermia in New Zealand involves two tests-in vitro contracture testing of excised lateral quadriceps muscle and DNA analysis. In vitro contracture testing is regarded as the gold standard in malignant hyperthermia diagnosis but several publications have questioned the reliability of a normal result. Analysis of 479 anaesthetic records in 280 patients or their descendants throughout New Zealand who had tested negative for malignant hyperthermia, demonstrated there was no evidence of malignant hyperthermia episodes in this group who had been administered anaesthetic triggering agents...
September 2017: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/28903010/effect-of-loading-on-in-vivo-tibiofemoral-and-patellofemoral-kinematics-of-healthy-and-acl-reconstructed-knees
#11
Jarred M Kaiser, Michael F Vignos, Richard Kijowski, Geoffrey Baer, Darryl G Thelen
BACKGROUND: Although knees that have undergone anterior cruciate ligament reconstruction (ACLR) often exhibit normal laxity on clinical examination, abnormal kinematic patterns have been observed when the joint is dynamically loaded during whole body activity. This study investigated whether abnormal knee kinematics arise with loading under isolated dynamic movements. HYPOTHESIS: Tibiofemoral and patellofemoral kinematics of ACLR knees will be similar to those of the contralateral uninjured control knee during passive flexion-extension, with bilateral differences emerging when an inertial load is applied...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28899822/early-strength-recovery-after-anterior-cruciate-ligament-reconstruction-using-the-fascia-lata
#12
Gregory Haillotte, Alexandre Hardy, Benjamin Granger, Thibaut Noailles, Fréderic Khiami
INTRODUCTION: After undergoing anterior cruciate ligament (ACL) reconstruction, patients must recover at least 80% of their hamstring and quadriceps strength to be able to return to sports without risk to the graft. Harvesting of the patellar tendon leads to large deficits in quadriceps strength, while harvesting the hamstring tendons leads to large deficits in hamstring strength. However, there are no published studies on the strength deficit after ACL reconstruction with the fascia lata...
September 9, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28893014/comparison-of-continuous-femoral-nerve-block-versus-local-infiltration-analgesia-as-a-postoperative-analgesia-in-unilateral-total-knee-arthroplasty
#13
Deepika Chaubey, Hari Krishan Mahajan, Parshu Ram Chauhan, Preeti S Govind, Pushpinder Singh, Ravinder Dhanevar, Abhinav Gupta
INTRODUCTION: Local infiltration of knee joint in arthroplasty, provide postoperative analgesia and preserves motor power of quadriceps, which helps in early mobilisation, as compared to femoral nerve block which paralyses vastus medialis. AIM: To compare the quality of postoperative analgesia provided by femoral nerve block and local infiltration in unilateral Total Knee Arthroplasty (TKA). MATERIALS AND METHODS: A prospective study was conducted on 60 patients (25-65 years) of ASA I and II, which were randomly(using random number table) divided into two groups - Group 1-femoral nerve block (FNB) and Group 2-Local Infiltration Analgesia (LIA)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28888715/acute-traumatic-rupture-of-the-patellar-tendon-in-pediatric-population-case-series-and-review-of-the-literature
#14
Mohamed Abdelhamid Ali Yousef, Scott Rosenfeld
BACKGROUND: Intact knee extensor mechanism is required for the normal function of the lower extremity. Patellar tendon rupture is a relatively rare injury with peak age incidence around 40 years and usually occurs midsubstance. The occurrence of pure patellar tendon rupture without bony avulsion is an extremely rare injury in the pediatric population with few cases reported in the literature with limited information regarding frequency, complications, and outcomes in children. However, due to increased participation in sports and high-energy recreational activities during childhood, the frequency of such injuries has progressively increased...
September 1, 2017: Injury
https://www.readbyqxmd.com/read/28887083/pres-leading-to-the-diagnosis-of-mcardle-disease
#15
Jennifer M Martinez-Thompson, Sean J Pittock, Margherita Milone
A 35year-old male developed myalgias after moving furniture and was hospitalized with acute renal failure and rhabdomyolysis requiring hemodialysis. He then had several generalized tonic-clonic seizures. Brain MRI showed findings of posterior reversible encephalopathy syndrome (PRES). Interval history revealed easy fatigability and exercise-induced myalgias in childhood but no preceding history of urine discoloration. Quadriceps biopsy showed absent muscle myophosphorylase reactivity consistent with the diagnosis of McArdle disease...
September 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28885155/a-nonlinear-dynamics-based-estimator-for-functional-electrical-stimulation-preliminary-results-from-lower-leg-extension-experiments
#16
Marcus Allen, Qiang Zhong, Nicholas Kirsch, Ashwin Dani, William W Clark, Nitin Sharma
Miniature inertial measurement units (IMUs) are wearable sensors that measure limb segment or joint angles during dynamic movements. However, IMUs are generally prone to drift, external magnetic interference, and measurement noise. This paper presents a new class of nonlinear state estimation technique called state-dependent coefficient (SDC) estimation to accurately predict joint angles from IMU measurements. The SDC estimation method uses limb dynamics, instead of limb kinematics, to estimate the limb state...
September 7, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28883721/determinants-of-each-domain-of-the-short-physical-performance-battery-in-copd
#17
Roberto Bernabeu-Mora, Luz M Giménez-Giménez, Joaquina Montilla-Herrador, Gloria García-Guillamón, José Antonio García-Vidal, Francesc Medina-Mirapeix
BACKGROUND: The Short Physical Performance Battery (SPPB) is an assessment tool with good prognostic value in COPD. It includes the following: standing balance, 4 m gait speed test (4MGS), and the timed five-repetition sit-to-stand test (5STS). The specific differences in determinants between these three tasks have not been adequately characterized in COPD patients. We aimed to identify health-related, functional, and psychological determinants of each SPPB test. METHODS: We conducted a cross-sectional analysis of 137 patients with stable COPD...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28882526/extra-foraminal-microscopic-assisted-percutaneous-nucleotomy-for-foraminal-and-extraforaminal-lumbar-disc-herniations
#18
Ahmed Shawky, Dusko Babic, Ahmed Ezzat Siam, Ali Ezzati
Background Foraminal and extraforaminal lumbar disc herniations are uncommon. The main presentation is radicular pain related to the exiting nerve root at the affected level. Different approaches for surgical intervention have been described. Purpose To evaluate the clinical outcome, complications recurrence and reoperation rate of extraforaminal microscopic assisted percutaneous nucleotomy with literature review focusing on complications and recurrence rate Study Design Prospective cohort study done in a high flow spine center in Germany Patient Sample Between October 2012 and October 2015, 76 patients (35 females and 41 males) with foraminal or extraforaminal lumbar disc prolapse were operated upon...
September 4, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28878908/a-case-report-of-spontaneous-rupture-of-the-quadriceps-tendon
#19
Xiuming Gao, Zhen Shao, Suwei Liu, Jie Xiang
Spontaneous quadriceps tendon rupture is a rare occurrence in patients with primary hyperparathyroidism (PHPT), which is less common in adolescents. We first reported a spontaneous unilateral rupture in a young patient with PHPT.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28878483/factors-affecting-dyspnea-after-the-6-minute-walk-test-in-idiopathic-pulmonary-fibrosis-patients-presenting-with-exercise-induced-hypoxemia
#20
Akira Morino, Hiroki Takahashi, Hirofumi Chiba, Sumio Ishiai
[Purpose] The current study aimed to investigate factors affecting dyspnea after the 6-minute walk test (6MWT) in idiopathic pulmonary fibrosis (IPF) patients presenting with hypoxemia. [Subjects and Methods] The subjects were IPF out-patients with stable symptoms whose percutaneous arterial oxygen saturation fell to 88% during the 6MWT test. Quadriceps force, 6-minute walk distance (6MWD), dyspnea after the 6MWT, and leg fatigue (LF) were evaluated as exercise-related variables. [Results] The subjects were 14 patients (mean age 73...
August 2017: Journal of Physical Therapy Science
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