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https://www.readbyqxmd.com/read/29741547/microenvironmental-influence-on-microtumour-infiltration-patterns-3d-mathematical-modelling-supported-by-in-vitro-studies
#1
Emmanuel Luján, Daniela Soto, María S Rosito, Alejandro Soba, Liliana N Guerra, Juan C Calvo, Guillermo Marshall, Cecilia Suárez
Mathematical modelling approaches have become increasingly abundant in cancer research. Tumour infiltration extent and its spatial organization depend both on the tumour type and stage and on the bio-physicochemical characteristics of the microenvironment. This sets a complex scenario that often requires a multidisciplinary and individually adjusted approach. The ultimate goal of this work is to present an experimental/numerical combined method for the development of a three-dimensional mathematical model with the ability to reproduce the growth and infiltration patterns of a given avascular microtumour in response to different microenvironmental conditions...
May 9, 2018: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/29722434/changes-in-hardness-and-resilience-of-i-gel-tm-cuffs-with-temperature-a-benchtop-study
#2
J Dingley, J Stephenson, V Allender, S Dawson, D Williams
The i-gelTM is a supraglottic airway with a gel-like thermoplastic cuff. It has been suggested that the seal around the larynx improves following insertion. Perhaps the most intuitive hypothesis proposed for this is that cuff softening occurs during warming from ambient to body temperature. We investigated this using a food industry texture analyser over a wide temperature range. Size 2 and 3 i-gels were secured to a platform within a temperature-controlled water bath, which was in turn mounted on a texture analyser test stand...
May 3, 2018: Anaesthesia
https://www.readbyqxmd.com/read/29720752/current-practice-patterns-of-supraglottic-airway-device-usage-in-paediatric-patients-amongst-anaesthesiologists-a-nationwide-survey
#3
Ruchi A Jain, Devangi A Parikh, Anila D Malde, Bhuvneshwari Balasubramanium
Background and Aims: Supraglottic airway devices (SGADs) are increasingly being used for airway management in paediatric patients undergoing general anaesthesia. This survey was designed to assess the nationwide practice patterns of SGAD usage in paediatric patients. Methods: A questionnaire of 28 questions was circulated amongst 16,532 members of the Indian Society of Anaesthesiologists through online survey engine Google Forms® and served manually to 500 delegates attending the Asian Society of Paediatric Anaesthesiologists conference 2017...
April 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29672533/protection-afforded-by-respirators-when-performing-endotracheal-intubation-using-a-direct-laryngoscope-glidescope%C3%A2-and-i-gel%C3%A2-device-a-randomized-trial
#4
Hyunggoo Kang, Yoonje Lee, Sanghyun Lee, Yeongtak Song, Tae Ho Lim, Jaehoon Oh, Juncheol Lee, Hyungoo Shin
Emergency physicians are at risk of infection during invasive procedures, and wearing a respirator can reduce this risk. The aim of this study was to determine whether the protection afforded by a respirator during intubation is affected by the type of airway device used. In this randomized crossover study, 26 emergency physicians underwent quantitative fit tests for a N95 respirator (cup-type or fold-type) before and during intubation with a direct laryngoscope, GlideScope®, or i-gel® airway device. The primary outcome was the fit factor value of the respirator and the secondary outcome was the level of acceptable protection provided (percentage of fit factor scores above 100)...
2018: PloS One
https://www.readbyqxmd.com/read/29643620/opioid-free-anesthesia-for-breast-cancer-surgery-an-observational-study
#5
Swagata Tripathy, Satyajit Rath, Suresh Agrawal, P Bhaskar Rao, A Panda, T S Mishra, Sukdev Nayak
Background and Aims: Opioids are associated with postoperative nausea, vomiting, drowsiness, and increased analgesic requirement. A nonopioid anesthesia technique may reduce morbidity, enable day care surgery, and possibly decrease tumor recurrence. We compared opioid-free, nerve block-based anesthesia with opioid-based general anesthesia for breast cancer surgery in a prospective cohort study. Material and Methods: Twenty four adult American Society of Anesthesiologists grade I-III patients posted for modified radical mastectomy (MRM) with axillary dissection were induced with propofol and maintained on isoflurane (0...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29628601/i-gel%C3%A2-may-be-the-device-of-choice-for-controlled-ventilation-in-patients-with-hemophilia-undergoing-abdominal-laparoscopic-surgery
#6
Sreyashi Sen, Koel Mitra, Shanta Ganguli, Sudakshina Mukherji
Haemophilia is an inherited bleeding disorder with variable deficiency of Factor VIII in the plasma and is characterised by bleeding into joints, muscles and tissues either spontaneously or in response to trivial trauma. Perioperative care requires multidisciplinary involvement. Perioperative management involves the risk of excessive bleeding from surgical site as well as spontaneous bleeding into the brain in response to surgical stress in patients with previous history of intracerebral haemorrhage. Airway management of such patients during anaesthetic intervention is a challenge and entails the risk of life threatening haemorrhage into the airway...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29618190/pre-hospital-i-gel-blind-intubation-for-trauma-a-simulation-study
#7
Jae Guk Kim, Wonhee Kim, Gu Hyun Kang, Yong Soo Jang, Hyun Young Choi, Hyeongtae Kim, Minji Kim
OBJECTIVE: This study aimed to evaluate the efficacy of i-gel blind intubation (IGI) as a rescue device for definitive airway management in ground intubation for pre-hospital trauma patients. METHODS: A prospective randomized crossover study was conducted with 18 paramedics to examine intubation performance of two blind intubation techniques through a supraglottic airway devices (IGI and laryngeal mask airway Fastrach), compared with use of a Macintosh laryngoscope (MCL)...
March 2018: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29497484/comparing-the-efficacy-and-safety-of-laryngeal-mask-airway-streamlined-liner-of-the-pharyngeal-airway-and-i-gel-following-tracheal-extubation
#8
Hesameddin Modir, Esmail Moshiri, Bijan Yazdi, Abolfazl Mohammadbeigi, Amirreza Modir
Adverse events following surgical operations are common complications due to removal of tracheal tube in contrast to the tracheal intubation. Awareness about the new methods and strategies for tracheal tube extubation is necessary for a safe and successful extubation. Therefore, we aimed to assess the safety and efficacy of laryngeal mask airway (LMA), streamlined liner of the pharyngeal airway (SLIPA) and I-gel in extubation time of tracheal tube. A one-single randomized clinical trial was conducted in 105 eligible patients in three groups including LMA, SLIPA and I-gel...
October 2017: Medical Gas Research
https://www.readbyqxmd.com/read/29491514/comparison-of-the-proseal-laryngeal-mask-airway-with-the-i-gel%C3%A2-in-the-different-head-and-neck-positions-in-anaesthetised-paralysed-children-a-randomised-controlled-trial
#9
Gargi Banerjee, Divya Jain, Indu Bala, Komal Gandhi, Ram Samujh
Background and Aims: Head and neck movements alter the shape of the pharynx, resulting in changes in the oropharyngeal leaking pressures and ventilation with supragottic airway devices. We compared the effect of the different head-and-neck positions on the oropharyngeal leak pressures and ventilation with the I-Gel™ and ProSeal™ laryngeal mask airway (PLMA) in anaesthetised paralysed children. Methods: A total of 70 children were randomly assigned to receive PLMA ( n = 35) or I-Gel™ ( n = 35) for airway management...
February 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29477748/transforming-growth-factor-%C3%AE-modulates-pancreatic-cancer-associated-fibroblasts-cell-shape-stiffness-and-invasion
#10
Andreas Stylianou, Vasiliki Gkretsi, Triantafyllos Stylianopoulos
BACKGROUND: Tumor microenvironment consists of the extracellular matrix (ECM), stromal cells, such as fibroblasts (FBs) and cancer associated fibroblasts (CAFs), and a myriad of soluble factors. In many tumor types, including pancreatic tumors, the interplay between stromal cells and the other tumor microenvironment components leads to desmoplasia, a cancer-specific type of fibrosis that hinders treatment. Transforming growth factor beta (TGF-β) and CAFs are thought to play a crucial role in this tumor desmoplastic reaction, although the involved mechanisms are unknown...
March 12, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29463314/functional-brain-specific-microvessels-from-ipsc-derived-human-brain-microvascular-endothelial-cells-the-role-of-matrix-composition-on-monolayer-formation
#11
Moriah E Katt, Raleigh M Linville, Lakyn N Mayo, Zinnia S Xu, Peter C Searson
BACKGROUND: Transwell-based models of the blood-brain barrier (BBB) incorporating monolayers of human brain microvascular endothelial cells (dhBMECs) derived from induced pluripotent stem cells show many of the key features of the BBB, including expression of transporters and efflux pumps, expression of tight junction proteins, and physiological values of transendothelial electrical resistance. The fabrication of 3D BBB models using dhBMECs has so far been unsuccessful due to the poor adhesion and survival of these cells on matrix materials commonly used in tissue engineering...
February 20, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29459640/self-assembled-collagen-fibrin-hydrogel-reinforces-tissue-engineered-adventitia-vessels-seeded-with-human-fibroblasts
#12
Bijal Patel, Zhengfan Xu, Cameron B Pinnock, Loay S Kabbani, Mai T Lam
Efforts for tissue engineering vascular grafts focuses on the tunica media and intima, although the tunica adventitia serves as the primary structural support for blood vessels. In surgery, during endarterectomies, surgeons can strip the vessel, leaving the adventitia as the main strength layer to close the vessel. Here, we adapted our recently developed technique of forming vascular tissue rings then stacking the rings into a tubular structure, to accommodate human fibroblasts to create adventitia vessels in 8 days...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452333/male-requires-a-higher-median-target-effect-site-concentration-of-propofol-for-i-gel-placement-when-combined-with-dexmedetomidine
#13
M-M Han, F-S Xue, F Kang, X Huang, J Li
OBJECTIVE: The supraglottic airway device (SAD) can be used for airway management of spontaneous breathing patients, and propofol is commonly applied for the SAD placement. This study was designed to assess the effect of gender on median target effect-site concentration (Ce50 ) of propofol for I-gel placement when combined with dexmedetomidine. MATERIAL AND METHOD: 19 males and 18 females, aged 18 to 59 and undergoing elective surgery, were enrolled. After intravenous infusion of dexmedetomidine 1...
February 13, 2018: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/29441173/a-comparison-of-i-gel%C3%A2-and-laryngeal-mask-airway-supreme%C3%A2-during-general-anesthesia-in-infants
#14
Yoon Chan Lee, Kyoung Seop Yoon, Sang Yoong Park, So Ron Choi, Chan Jong Chung
Background: The i-gel™ (i-gel) and Laryngeal Mask Airway Supreme™ (LMA Supreme) have been safely used in children. We compared the airway performance of the i-gel and LMA Supreme in infants undergoing general anesthesia. Methods: Sixty infants with American Society of Anesthesiologists physical status I or II were randomly assigned to place either the i-gel or the LMA Supreme. The size 1 or 1.5 of each airway was selected by the weight of infants. The primary outcome variable was oropharyngeal leak pressure (OLP)...
February 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29441171/optimal-propofol-dosage-for-i-gel%C3%A2-insertion-in-healthy-paralyzed-patients
#15
Sung-Ae Cho, Tae-Yun Sung, Choon-Kyu Cho, Young Seok Jee, Po-Soon Kang
Background: Propofol is used for supraglottic airway device insertion, often with the i-gel. However, the propofol requirement for i-gel insertion has not been explored in paralyzed patients. This study was performed to explore hemodynamic changes and sedation level with different propofol doses in healthy paralyzed patients when the i-gel was inserted. Methods: A total of 141 patients undergoing a urologic operation were randomly allocated to three groups depending on the propofol dose (1...
February 2018: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29430409/a-novel-and-modified-technique-in-the-prone-position-for-radiotherapy-processes-in-children
#16
Ozkan Onal, Emine Aslanlar, Cansu Ciftci, Merih Onal, Jale Bengi Celik
The i-gel has a thick airway tube and occasionally, achieving the airway can be difficult because of obstruction in the prone position. The authors aimed at solving this problem and used a modified i-gel airway in the prone position for radiotherapy processes in children.
August 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29417934/functionalized-thermosensitive-hydrogel-combined-with-tendon-stem-progenitor-cells-as-injectable-cell-delivery-carrier-for-tendon-tissue-engineering
#17
Heyong Yin, Zexing Yan, Richard J Bauer, Jiang Peng, Matthias Schieker, Michael Nerlich, Denitsa Docheva
Thermosensitive hydrogels have been studied for potential application as promising alternative cell carriers in cell-based regenerative therapies. In this study, a thermosensitive butane diisocyanate (BDI)-collagen hydrogel (BC hydrogel) was designed as an injectable cell delivery carrier of tendon stem/progenitor cells (TSPCs) for tendon tissue engineering. We functionalized the BDI hydrogel with the addition of 20% (v/v) collagen I gel to obtain the thermosensitive BC hydrogel, which was then seeded with TSPCs derived from human Achilles tendons...
March 16, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29417920/emergency-airway-management-in-a-simulation-of-highly-contagious-isolated-patients-both-isolation-strategy-and-device-type-matter
#18
Eike Plazikowski, Robert Greif, Jonas Marschall, Tina H Pedersen, Maren Kleine-Brueggeney, Roland Albrecht, Lorenz Theiler
OBJECTIVE To compare 6 airway-management devices in 3 isolation scenarios regarding their effect on airway management: portable isolation unit (PIU), personal protective equipment (PPE), and standard protection measures METHODS In total, 30 anesthesiologists working in emergency medical services performed airway management on mannequins in 3 isolation settings using 6 different airway management devices (in random order): (1) standard Macintosh laryngoscope; (2) Airtraq SP-video-laryngoscope; (3) i-gel; (4) LMA-Fastrach; (5) Ambu fiberoptic-aScope; and (6) Melker cricothyrotomy-set...
February 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29416263/fiberoptic-guided-intubation-after-awake-insertion-of-the-i-gel%C3%A2-supraglottic-device-in-a-patient-with-predicted-difficult-airway
#19
Julian Arevalo Ludena, Jose Juan Arcas Bellas, Rafael Alvarez-Rementeria, Luis Enrique Munoz
No abstract text is available yet for this article.
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29416256/use-of-the-magill-forceps-as-an-aid-for-i-gel-%C3%A2-removal-after-endotracheal-intubation-a-safe-and-simple-technique
#20
Julian Arevalo Ludeña, Luis Enrique Muñoz Alameda
No abstract text is available yet for this article.
October 2017: Journal of Anaesthesiology, Clinical Pharmacology
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