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https://www.readbyqxmd.com/read/29338895/feasibility-of-total-intravenous-anesthesia-by-cardiologists-with-the-support-of-anesthesiologists-during-catheter-ablation-of-atrial-fibrillation
#1
Takanori Yamaguchi, Yusuke Shimakawa, Shinji Mitsumizo, Akira Fukui, Yuki Kawano, Toyokazu Otsubo, Yuya Takahashi, Kei Hirota, Takeshi Tsuchiya, Kenichi Eshima
BACKGROUND: The optimal methodology for sedation and anesthesia during atrial fibrillation (AF) ablation has not been well established. We assessed the feasibility of total intravenous anesthesia (TIVA) by cardiologists with support from anesthesiologists during AF ablation and quality of pulmonary vein isolation (PVI) and single procedure success rate at 12 months. METHODS: TIVA was performed by cardiologists using IV propofol and fentanyl under controlled ventilation via i-gel™ without neuromuscular blocking drugs in 160 consecutive patients (80 nonparoxysmal) with no anticipated difficult airway or other severe diseases...
January 12, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29330036/regulation-of-fibrotic-changes-by-the-synergistic-effects-of-cytokines-dimensionality-and-matrix-towards-the-development-of-an-in-vitro-human-dermal-hypertrophic-scar-model
#2
Shikha Chawla, Sourabh Ghosh
Current therapeutic strategies to reduce scarring in full thickness skin defect offer limited success due to poor understanding of scar tissue formation and the underlying signaling pathways. There is an urgent need to develop human cell based in vitro scar tissue models as animal testing is associated with ethical and logistic complications and inter-species variations. Pro-inflammatory cytokines play critical role in regulating scar development through complex interplay and interaction with the ECM and corresponding signaling pathways...
January 9, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29307902/a-randomised-controlled-trial-comparing-proseal-laryngeal-mask-airway-i-gel-and-laryngeal-tube-suction-d-under-general-anaesthesia-for-elective-surgical-patients-requiring-controlled-ventilation
#3
Bikramjit Das, Rahul Varshney, Subhro Mitra
Background and Aims: The ProSeal™ laryngeal mask airway (PLMA), i-gel™ and Laryngeal Tube Suction-D (LTS-D™) have previously been evaluated alone or in pair-wise comparisons but differing study designs make it difficult to compare the results. The aim of this study was to compare the clinical performance of these three devices in terms of efficacy and safety in patients receiving mechanical ventilation during elective surgical procedures. Methods: This prospective, randomised, double-blind study was conducted on 150 American Society of Anesthesiologists physical status I-II patients, randomly allocated into 3 groups, undergoing elective surgical procedures under general anaesthesia...
December 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29284851/comparison-of-i-gel-versus-endotracheal-tube-in-patients-undergoing-elective-cesarean-section-a-prospective-randomized-control-study
#4
Manohar Panneer, Saravana Babu, Prakash Murugaiyan
Background and Aim: Physiological changes during pregnancy and the sympatho adrenalstimulation during larynoscopy and intubation leads to evaluation of safe devices to secure airway during cesarean section under general anesthesia. I-gel, recently emerging effective supra glottic device found safe during general anesthesia in cesarean section. Aim of the study is to compare the hemodynamic disturbances and airway related complications of I-gel and Endotracheal tube in patients undergoing cesarean section under general anesthesia...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29284832/application-of-discharge-criteria-for-home-readiness-using-bispectral-and-supraglottic-airway-devices-in-day-care-surgery-without-using-muscle-relaxants
#5
Joginder Pal Attri, Manjit Singh, Hemchandra Bhatt, Kamal Jyoti, Harjinder Kaur
Introduction: The availability of rapid and short-acting intravenous and volatile anesthetics has facilitated early recovery that is why nowadays ambulatory surgery is becoming more common. If the criteria used to discharge patients from the Postanesthesia Care Unit (PACU) are met in the operating room (OR), it would be appropriate to consider bypassing the PACU and transferring the patient directly to the step-down unit. This process is known as "fast-tracking" after ambulatory surgery...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29274473/tyro3-mediated-phosphorylation-of-actn4-at-tyrosines-is-fak-dependent-and-decreases-susceptibility-to-cleavage-by-m-calpain
#6
Hanshuang Shao, Anna Wang, Douglas Lauffenburger, Alan Wells
Tyro3, a member of TAM receptor tyrosine kinase family, has been implicated in the regulation of melanoma progression and survival. In this study, we sought the molecular mechanism of Tyro3 effects avoiding endogenous background by overexpression of Tyro3 in fibroblasts that have negligible levels of Tyro3. This introduction triggers the tyrosyl-phosphorylation of ACTN4, a member of actin binding protein family involved in motility, a behavior critical for invasive progression, as shown by siRNA to Tyro3 limiting melanoma cell migration and invasion...
December 20, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29209682/erratum-ambu-auraonce-versus-i-gel-laryngeal-mask-airway-in-infants-and-children-undergoing-surgical-procedures-a-randomized-controlled-trial
#7
Abdulrahman M Alzahem, Mansoor Aqil, Tariq A Alzahrani, Ayman H Aljazaeri
[No Abstract Available].
December 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29209679/comparing-i-gel-and-ambu-auraonce-laryngeal-mask-airway-in-pediatric-patients
#8
Gui-Zhen Yang, Fu-Shan Xue, Hui-Xian Li, Ya-Yang Liu
[No Abstract Available].
December 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/29144435/dysregulated-collagen-homeostasis-by-matrix-stiffening-and-tgf-%C3%AE-1-in-fibroblasts-from-idiopathic-pulmonary-fibrosis-patients-role-of-fak-akt
#9
Alícia Giménez, Paula Duch, Marta Puig, Marta Gabasa, Antoni Xaubet, Jordi Alcaraz
Idiopathic pulmonary fibrosis (IPF) is an aggressive disease in which normal lung parenchyma is replaced by a stiff dysfunctional scar rich in activated fibroblasts and collagen-I. We examined how the mechanochemical pro-fibrotic microenvironment provided by matrix stiffening and TGF-β1 cooperates in the transcriptional control of collagen homeostasis in normal and fibrotic conditions. For this purpose we cultured fibroblasts from IPF patients or control donors on hydrogels with tunable elasticity, including 3D collagen-I gels and 2D polyacrylamide (PAA) gels...
November 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29120819/towards-a-defined-ecm-and-small-molecule-based-monolayer-culture-system-for-the-expansion-of-mouse-and-human-intestinal-stem-cells
#10
Zhixiang Tong, Keir Martyn, Andy Yang, Xiaolei Yin, Benjamin E Mead, Nitin Joshi, Nicholas E Sherman, Robert S Langer, Jeffrey M Karp
Current ISC culture systems face significant challenges such as animal-derived or undefined matrix compositions, batch-to-batch variability (e.g. Matrigel-based organoid culture), and complexity of assaying cell aggregates such as organoids which renders the research and clinical translation of ISCs challenging. Here, through screening for suitable ECM components, we report a defined, collagen based monolayer culture system that supports the growth of mouse and human intestinal epithelial cells (IECs) enriched for an Lgr5(+) population comparable or higher to the levels found in a standard Matrigel-based organoid culture...
October 26, 2017: Biomaterials
https://www.readbyqxmd.com/read/29114411/clinical-comparison-of-i-gel-supraglottic-airway-device-and-cuffed-endotracheal-tube-for-pressure-controlled-ventilation-during-routine-surgical-procedures
#11
Ankur Dhanda, Shalendra Singh, Anju R Bhalotra, Siddharth Chavali
Objective: Recently, there has been a trend favouring the use of supraglottic airway devices over endotracheal tubes (ETT) during short surgical procedures. In this study, we are going to assess the suitability of one such supraglottic airway device, i-gel, for pressure-controlled ventilation (PCV) during routine surgical procedures. Methods: The airway management for 60 patients was done with either i-gel (Group I) or cuffed tracheal tube (Group E) for this prospective, randomised, double-blinded study...
October 2017: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29084373/residual-sodium-dodecyl-sulfate-in-decellularized-muscle-matrices-leads-to-fibroblast-activation-in-vitro-and-foreign-body-response-in-vivo
#12
Emily E Friedrich, Steven T Lanier, Soleil Niknam-Bienia, Gabriel A Arenas, Divya Rajendran, Jason A Wertheim, Robert D Galiano
Detergents such as sodium dodecyl sulfate (SDS) are commonly used to extract cells from tissues in a process called 'decellularization'. Residual SDS is difficult to completely remove and may lead to an undesirable host response toward an implanted biomaterial. In this study, we developed a modification for SDS cell extraction from muscle equally efficient to previous methods but leading to significantly less residual SDS remnants in the matrices. Muscle-derived matrices were prepared via two SDS-based decellularization methods, which led to removal of either 81...
October 30, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29066653/use-of-i-gel-for-laser-ablation-of-a-bronchial-lesion
#13
Rakesh Garg, Sakshi Thakore, Karan Madan, Anant Mohan
The use of laser for airway lesions requires airway management. Usual options include special laser-resistant endotracheal tubes. The use of supraglottic devices have been described in the literature. Laryngeal mask airway carries the risk of cuff damage during the use of laser. i-gel is made of thermoplastic material and does not require air inflation and thus potentially reduce the risk of cuff rupture. i-gel use in laser surgeries has not been described in the literature. We present successful airway management in laser surgery for bronchial tumour using i-gel...
October 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29033717/comparison-of-oropharyngeal-leak-pressure-of-air-q%C3%A2-i-gel%C3%A2-and-laryngeal-mask-airway-supreme%C3%A2-in-adult-patients-during-general-anesthesia-a-randomized-controlled-trial
#14
Srinath Damodaran, Sameer Sethi, Surender Kumar Malhotra, Tanvir Samra, Souvik Maitra, Vikas Saini
STUDY OBJECTIVE: Various randomized controlled trials and a meta-analysis have compared i-gel™ and laryngeal mask airway Supreme™ (LMA-S™) in adult patients and found that both the devices provided equivalent oropharyngeal leak pressure (OLP). However, no randomized controlled trial has compared air-Q™ with i-gel™ and LMA-S™ in adult patient. Hence, we designed this study to compare air-Q™ with LMA-S™ and i-gel™ in adult patients. MATERIALS AND METHODS: A total of 75 adult patients of the American Society of Anesthesiologists physical status I/II of both sexes, between 18 and 60 years, were included in this prospective randomized controlled trial conducted in a tertiary care center...
October 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28928564/comparison-of-i-gel%C3%A2-and-laryngeal-mask-airway-supreme%C3%A2-in-different-head-and-neck-positions-in-spontaneously-breathing-pediatric-population
#15
Swati Gupta, Neelam Dogra, Kanchan Chauhan
BACKGROUND: Although the advantages of ventilation with i-gel™ and laryngeal mask airway Supreme (LMA-Supreme™) has been well documented, they are still under debate for surgeries requiring flexion and extension of neck such as thyroid surgery, tonsillectomy, and neck exploration. Hence, we conducted a study to demonstrate the effect of neck flexion and extension in spontaneously breathing anesthetized pediatric patients utilizing i-gel™ and LMA-Supreme™. METHODS: A prospective, randomized comparative study was conducted on sixty children, thirty each in i-gel™ and LMA-Supreme™ group...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28920047/the-effects-of-endotracheal-tube-and-i-gel%C3%A2-supraglottic-airway-device-on-respiratory-impedance-a-prospective-observational-study
#16
Shoko Nakano, Junko Nakahira, Yosuke Kuzukawa, Toshiyuki Sawai, Toshiaki Minami
BACKGROUND: The forced oscillation technique (FOT) is a non-invasive means of measuring respiratory resistance and reactance. We tested our hypothesis that endotracheal intubation would cause more substantial preoperative increases in FOT parameters than a supraglottic airway device (SGD). METHODS: Forty patients requiring general anesthesia and mechanical ventilation for transurethral bladder tumor resection underwent spirometry the day before surgery. Forced oscillation was measured using a MostGraph-01 device the day before surgery and immediately after removal of the airway adjunct...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28912163/neonatal-resuscitation-using-a-laryngeal-mask-airway-a-randomised-trial-in-uganda
#17
Nicolas J Pejovic, Daniele Trevisanuto, Clare Lubulwa, Susanna Myrnerts Höök, Francesco Cavallin, Josaphat Byamugisha, Jolly Nankunda, Thorkild Tylleskär
OBJECTIVE: Mortality rates from birth asphyxia in low-income countries remain high. Face mask ventilation (FMV) performed by midwives is the usual method of resuscitating neonates in such settings but may not always be effective. The i-gel is a cuffless laryngeal mask airway (LMA) that could enhance neonatal resuscitation performance. We aimed to compare LMA and face mask (FM) during neonatal resuscitation in a low-resource setting. SETTING: Mulago National Referral Hospital, Kampala, Uganda...
September 14, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28874304/effect-of-cricoid-pressure-on-the-insertion-efficacy-of-six-supraglottic-devices-a-crossover-randomized-simulation-trial
#18
Fumihiro Ohchi, Nobuyasu Komasawa, Ryosuke Mihara, Kazuo Hattori, Toshiaki Minami
BACKGROUND: No study has ever compared the efficacy of various types of supraglottic devices (SGDs) for securing the airway under cricoid pressure. OBJECTIVE: This study aimed to evaluate the efficacy of six SGDs, LMA-ProSeal (ProSeal), LMA-Classic (Classic), Laryngeal Tube (LT), LMA-Supreme (Supreme), air-Q (air-Q), and i-gel (i-gel), in airway management under cricoid pressure using a manikin. METHODS: Fifteen novice doctors and 16 experienced doctors used the six SGDs under cricoid or sham pressure on an adult manikin...
November 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28857785/comparison-of-the-laryngeal-mask-airway-supreme-and-the-i-gel-in-paralysed-elderly-patients-a-randomised-controlled-trial
#19
Myoung H Kim, Jae H Lee, Yong S Choi, Sujung Park, Seokyung Shin
BACKGROUND: The laryngeal mask airway supreme (LMA-S) and i-gel are both popular second-generation supraglottic airway devices that have been widely studied in surgical patients, but their differences in clinical performance in the elderly are not clear. OBJECTIVE: We compared the efficacy and safety of the LMA-S and i-gel in anaesthetised and paralysed elderly patients. DESIGN: A prospective, randomised and parallel study. SETTING: Single-centre trial, study period January 2014 from to October 2016...
August 28, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28802606/comparison-of-lma-supreme%C3%A2-with-i-gel%C3%A2-and-lma-proseal%C3%A2-in-children-for-airway-management-during-general-anaesthesia-a-meta-analysis-of-randomized-controlled-trials
#20
Sulagna Bhattacharjee, Anirban Som, Souvik Maitra
STUDY OBJECTIVE: A few randomized trials have compared LMA Supreme™ with LMA ProSeal™ and i-gel™ in children but their conclusions varied widely. This systematic review and meta analysis has compared the former device with the latter two devices. DESIGN: Meta-analysis and systematic review using the Mantel-Haenszel method and pooled mean difference using inverse variance method. SETTING: Meta-analysis of published prospective randomized controlled trials...
September 2017: Journal of Clinical Anesthesia
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