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https://www.readbyqxmd.com/read/28737223/a-network-meta-analysis-of-the-clinical-properties-of-various-types-of-supraglottic-airway-device-in-children
#1
REVIEW
T Mihara, A Asakura, G Owada, A Yokoi, K Ka, T Goto
We conducted both conventional pairwise and Bayesian network meta-analyses to compare the clinical properties of supraglottic airway devices in children. We searched six databases for randomised clinical trials. Our primary end-points were oropharyngeal leak pressure, risk of insertion failure at first attempt, and blood staining risk. The risk of device failure, defined as the abandonment of the supraglottic airway device and replacement with a tracheal tube or another device, was also analysed. Sixty-five randomised clinical trials with 5823 participants were identified, involving 16 types of supraglottic airway device...
July 24, 2017: Anaesthesia
https://www.readbyqxmd.com/read/28686017/analysis-and-characterization-of-polychlorinated-hydroxybornanes-as-metabolites-of-toxaphene-using-polar-bear-model
#2
Lea Reger, Christoph Gallistl, Karl Skirnisson, Walter Vetter
Abiotic and biotic transformation of toxaphene (camphechlor) results in the selective enrichment of recalcitrant congeners while other, less persistent compounds of technical toxaphene (CTTs) are degraded. Up to now there is little knowledge on oxidation transformation of toxaphene. For instance, existence of hydroxylated CTTs (OH-CTTs) in authentic environmental and food samples was not proven yet. For this reason, we synthesized a mixture consisting of tetra- to heptachlorinated OH-CTTs and simplified it by countercurrent chromatography (CCC)...
July 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28672891/osteogenic-potency-of-dedifferentiated-fat-cells-isolated-from-elderly-people-with-osteoporosis
#3
Wei Hao, Chuanqiang Jiang, Ming Jiang, Tian Wang, Xin Wang
Mature adipocytes are the major cell type in adipose tissue. This study aimed to explore the osteogenic potency of dedifferentiated fat cells obtained from osteoporotic patients (opDFATs) in vitro and in vivo. Mature adipocytes and adipose-derived stem cells (opASCs) were harvested from subcutaneous adipose tissue. Mature adipocytes were dedifferentiated to produce opDFATs by the ceiling culture method. OpDFATs were osteogenically induced in vitro with opASCs as a control. Cell growth, alkaline phosphatase (ALPase) activity and cell mineralization were determined, and expression levels of osteogenesis-specific genes (collagen I, osteocalcin and bone sialoprotein) were analyzed using quantitative reverse transcription polymerase chain reaction...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28658119/is-neuromuscular-blocker-needed-in-children-undergoing-inguinal-herniorrhaphy-a-prospective-randomized-and-controlled-trial
#4
RANDOMIZED CONTROLLED TRIAL
Bon-Wook Koo, Kyu-Whan Jung, Ah-Young Oh, Eun-Young Kim, Hyo-Seok Na, Eun-Su Choi, Kwang-Suk Seo
BACKGROUND: Intraoperative neuromuscular blocker is widely used, but is known to be associated with postoperative residual paralysis, which is known to be associated with increased risk of pulmonary complications. Hence, its use should be individualized and restricted to procedures where it is mandatory. We examined whether not using a neuromuscular blocker affects the surgical conditions in children undergoing inguinal herniorrhaphy. METHODS: Anesthesia was induced and maintained with sevoflurane in 60% nitrous oxide, and the airway was maintained using an I-gel...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28634939/an-organotypic-3d-assay-for-primary-human-mammary-epithelial-cells-that-recapitulates-branching-morphogenesis
#5
Jelena R Linnemann, Lisa K Meixner, Haruko Miura, Christina H Scheel
We have developed a three-dimensional organotypic culture system for primary human mammary epithelial cells (HMECs) in which the cells are cultured in free floating collagen type I gels. In this assay, luminal cells predominantly form multicellular spheres, while basal/myoepithelial cells form complex branched structures resembling terminal ductal lobular units (TDLUs), the functional units of the human mammary gland in situ. The TDLU-like organoids can be cultured for at least 3 weeks and can then be passaged multiple times...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28625432/the-lma-supreme-is-it-a-suitable-alternative-to-the-i-gel-and-lma-proseal-for-airway-maintenance-in-children
#6
EDITORIAL
Narasimhan Jagannathan, Jahn Hajduk
No abstract text is available yet for this article.
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28580492/effect-of-concentration-of-collagen-gel-on-functional-activity-of-bone-marrow-mesenchymal-stromal-cells
#7
Yu A Nashchekina, N M Yudintceva, P O Nikonov, E A Ivanova, L V Smagina, I V Voronkina
Collagen I gels with protein concentrations of 1, 2, and 3.5 mg/ml were prepared and embedded in a porous polylactide scaffold to reduce their contraction. Concentration of the gel did not affect its degradation. Collagen gels promoted the formation of cell networks. The cells in the collagen gel with a concentration of 1 mg/ml embedded in polylactide scaffold had elongated spindle-like shape, in contrast to flattened cells in collagen gel of the same concentration not embedded in the scaffold. Stabilization of the collagen gel in the polylactide scaffold promoted active synthesis of laminin and fibronectin by cells as soon as on day 5 of culturing in comparison with that in free collagen substrate...
June 3, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28578948/gelation-of-rhamnogalacturonan-i-is-based-on-galactan-side-chain-interaction-and-does-not-involve-chemical-modifications
#8
Polina V Mikshina, Olga N Makshakova, Anna A Petrova, Ilzira Z Gaifullina, Bulat Z Idiyatullin, Tatyana A Gorshkova, Yuriy F Zuev
The article presents the structural principles of microwave-induced formation of new gel type from pectic rhamnogalacturonan I (RG-I). The backbone of gel-forming RG-I does not contain consecutive galacturonic residues and modifying groups that can be the cause of junction zone formation as it occurs in course of classical ways of pectin gelation. Microwave irradiation does not cause destruction and chemical modifications of RG-I. Removal of half of galactan chains from RG-I leads to loss of gelling capability pointing out on their leading role in this process...
September 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28518082/maturation-of-human-stem-cell-derived-cardiomyocytes-in-biowires-using-electrical-stimulation
#9
Xuetao Sun, Sara S Nunes
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have been a promising cell source and have thus encouraged the investigation of their potential applications in cardiac research, including drug discovery, disease modeling, tissue engineering, and regenerative medicine. However, cells produced by existing protocols display a range of immaturity compared with native adult ventricular cardiomyocytes. Many efforts have been made to mature hPSC-CMs, with only moderate maturation attained thus far. Therefore, an engineered system, called biowire, has been devised by providing both physical and electrical cues to lead hPSC-CMs to a more mature state in vitro...
May 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28489804/comparison-of-learning-performance-of-2-intubating-laryngeal-mask-airways-in-novice-a-randomized-crossover-manikin-study
#10
RANDOMIZED CONTROLLED TRIAL
Zi-Jia Liu, Jie Yi, Wei-Yun Chen, Xiu-Hua Zhang, Yu-Guang Huang
BACKGROUND: Intubating laryngeal mask airways (LMAs) such as i-gel and Aura-i could serve as rescue devices in resuscitation and further ensure the airway by facilitating trachea intubation without ventilation interruption. But data regarding intubating LMAs in novice are limited and skill degeneration without regular training has not been evaluated. So we designed this prospective randomized crossover manikin study to compare the learning performance of 2 intubating LMAs (i-gel and Aura-i)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28471973/a-randomized-comparison-of-volume-and-pressure-controlled-ventilation-in-children-with-the-i-gel-effects-on-peak-inspiratory-pressure-oropharyngeal-leak-pressure-and-gastric-insufflation
#11
RANDOMIZED CONTROLLED TRIAL
Jin Ha Park, Ji Young Kim, Kyoungun Park, Hae Keum Kil
BACKGROUND: The i-gel provides good airway sealing but gastric insufflation may occur when peak inspiratory pressure (PIP) exceeds the sealing pressure of the i-gel without a gastric tube. Pressure-controlled ventilation (PCV) provides lower PIP compared with volume-controlled ventilation (VCV) and low PIP may reduce the incidence of gastric insufflation in children during positive pressure ventilation. This study was designed to evaluate PIP, oropharyngeal leak pressure, and gastric insufflation during VCV or PCV in children undergoing general anesthesia with i-gel without a gastric tube in situ...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28439597/ambu-auraonce-versus-i-gel-laryngeal-mask-airway-in-infants-and-children-undergoing-surgical-procedures-a-randomized-controlled-trial
#12
Abdulrahman M Alzahem, Mansoor Aqil, Tariq A Alzahrani, Ayman H Aljazaeri
To compare the efficacy and performance of the pediatric Ambu AuraOnce (Ambu AO) mask (Ambu, Copenhagen, Denmark) and i-gel mask (Intersurgical Ltd., Wokingham, United Kingdom). Methods: From May 2015 to September 2016, 112 patients, 0-14 years old, underwent elective surgery at a tertiary university hospital (Riyadh, Saudi Arabia). They were randomly assigned to the Ambu AO or i-gel group. Three groups underwent a subgroup analysis: ≤5 kg (group 1), 5.1-10.0 kg (group 2), and >10 kg (group 3). Results: The oropharyngeal leak pressure was significantly higher for the i-gel (25...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28423706/identification-of-ras-suppressor-1-rsu-1-as-a-potential-breast-cancer-metastasis-biomarker-using-a-three-dimensional-in-vitro-approach
#13
Vasiliki Gkretsi, Andreas Stylianou, Maria Louca, Triantafyllos Stylianopoulos
Breast cancer (BC) is the most common malignant disease in women, with most patients dying from metastasis to distant organs, making discovery of novel metastasis biomarkers and therapeutic targets imperative. Extracellular matrix (ECM)-related adhesion proteins as well as tumor matrix stiffness are important determinants for metastasis. As traditional two-dimensional culture does not take into account ECM stiffness, we employed 3-dimensional collagen I gels of increasing concentration and stiffness to embed BC cells of different invasiveness (MCF-7, MDA-MB-231 and MDA-MB-231-LM2) or tumor spheroids...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28245809/mesenchymal-stem-cells-and-myoblast-differentiation-under-hgf-and-igf-1-stimulation-for-3d-skeletal-muscle-tissue-engineering
#14
R Witt, A Weigand, A M Boos, A Cai, D Dippold, A R Boccaccini, D W Schubert, M Hardt, C Lange, A Arkudas, R E Horch, J P Beier
BACKGROUND: Volumetric muscle loss caused by trauma or after tumour surgery exceeds the natural regeneration capacity of skeletal muscle. Hence, the future goal of tissue engineering (TE) is the replacement and repair of lost muscle tissue by newly generating skeletal muscle combining different cell sources, such as myoblasts and mesenchymal stem cells (MSCs), within a three-dimensional matrix. Latest research showed that seeding skeletal muscle cells on aligned constructs enhance the formation of myotubes as well as cell alignment and may provide a further step towards the clinical application of engineered skeletal muscle...
February 28, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28236864/a-comparison-of-various-supraglottic-airway-devices-for-fiberoptical-guided-tracheal-intubation
#15
RANDOMIZED CONTROLLED TRIAL
Thomas Metterlein, Anna Dintenfelder, Christoph Plank, Bernhard Graf, Gabriel Roth
BACKGROUND: Fiberoptical assisted intubation via placed supraglottic airway devices has been described as safe and easy procedure to manage difficult airways. However visualization of the glottis aperture is essential for fiberoptical assisted intubation. Various different supraglottic airway devices are commercially available and might offer different conditions for fiberoptical assisted intubation. The aim of this study was to compare the best obtainable view of the glottic aperture using different supraglottic airway devices...
March 2017: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/28209486/vasodilator-stimulated-phosphoprotein-vasp-depletion-from-breast-cancer-mda-mb-231-cells-inhibits-tumor-spheroid-invasion-through-downregulation-of-migfilin-%C3%AE-catenin-and-urokinase-plasminogen-activator-upa
#16
Vasiliki Gkretsi, Andreas Stylianou, Triantafyllos Stylianopoulos
A hallmark of cancer cells is their ability to invade surrounding tissues and form metastases. Cell-extracellular matrix (ECM)-adhesion proteins are crucial in metastasis, connecting tumor ECM with actin cytoskeleton thus enabling cells to respond to mechanical cues. Vasodilator-stimulated phosphoprotein (VASP) is an actin-polymerization regulator which interacts with cell-ECM adhesion protein Migfilin, and regulates cell migration. We compared VASP expression in MCF-7 and MDA-MB-231 breast cancer (BC) cells and found that more invasive MDA-MB-231 cells overexpress VASP...
March 15, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28194529/a-randomized-clinical-study-on-postoperative-pain-comparing-between-the-supraglottic-airway-device-and-endotracheal-tubing-in-transabdominal-preperitoneal-repair-tapp
#17
Y Nagahisa, K Hashida, R Matsumoto, R Kawashima, M Okabe, K Kawamoto
BACKGROUND: Transabdominal preperitoneal (TAPP) repair is the most widely used laparoscopic technique for the treatment of inguinal hernia in Japan. Many studies have shown that in comparison with open hernia repair, laparoscopic repair results in less pain and a shorter convalescence. However, postoperative pain remains a concern. One possible cause of postoperative pain in the early postoperative phase is strain or cough on removal of the endotracheal tube. Use of a supraglottic airway (SGA) device helps to avoid such complaints...
February 13, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28164708/expanding-proteome-coverage-with-charge-ordered-parallel-ion-analysis-chopin-combined-with-broad-specificity-proteolysis
#18
Simon Davis, Philip D Charles, Lin He, Peter Mowlds, Benedikt M Kessler, Roman Fischer
The "deep" proteome has been accessible by mass spectrometry for some time. However, the number of proteins identified in cells of the same type has plateaued at ∼8000-10 000 without ID transfer from reference proteomes/data. Moreover, limited sequence coverage hampers the discrimination of protein isoforms when using trypsin as standard protease. Multienzyme approaches appear to improve sequence coverage and subsequent isoform discrimination. Here we expanded proteome and protein sequence coverage in MCF-7 breast cancer cells to an as yet unmatched depth by employing a workflow that addresses current limitations in deep proteome analysis in multiple stages: We used (i) gel-aided sample preparation (GASP) and combined trypsin/elastase digests to increase peptide orthogonality, (ii) concatenated high-pH prefractionation, and (iii) CHarge Ordered Parallel Ion aNalysis (CHOPIN), available on an Orbitrap Fusion (Lumos) mass spectrometer, to achieve 57% median protein sequence coverage in 13 728 protein groups (8949 Unigene IDs) in a single cell line...
March 3, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28153678/i-gel-o2-resus-pack-a-rescue-device-in-case-of-severe-facial-injury-and-difficult-intubation
#19
Fabio Baratto, Giulia Gabellini, Anrdea Paoli, Annalisa Boscolo
No abstract text is available yet for this article.
January 26, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28125979/i-gel-is-a-suitable-alternative-to-endotracheal-tubes-in-the-laparoscopic-pneumoperitoneum-and-trendelenburg-position
#20
Chih-Jun Lai, Chih-Min Liu, Chun-Yu Wu, Feng-Fang Tsai, Ping-Huei Tseng, Shou-Zen Fan
BACKGROUND: The use of supraglottic airway devices (SADs) in surgeries with laparoscopic pneumoperitoneum and Trendelenburg (LPT) positioning is controversial due to concerns about insufficient pulmonary ventilation and aspiration. In this prospective, randomized-controlled trial, we evaluated whether the i-gel, a new second generation SAD, provides an effective alternative to an endotracheal tube (ETT) by comparing respiratory parameters and perioperative respiratory complications in non-obese patients...
January 6, 2017: BMC Anesthesiology
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