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https://www.readbyqxmd.com/read/27922176/dipeptidyl-peptidase-4-inhibitor-sitagliptin-reduces-inflammation-fibrosis-and-preserves-diastolic-function-in-a-rat-model-of-heart-failure-with-preserved-ejection-fraction
#1
Grazia Esposito, Donato Cappetta, Rosa Russo, Alessia Rivellino, Loreta Pia Ciuffreda, Fiorentina Roviezzo, Elena Piegari, L Liberato Berrino, Francesco Rossi, Antonella De Angelis, Konrad Urbanek
BACKGROUND AND PURPOSE: Heart failure with preserved ejection fraction (HFpEF) is a systemic syndrome driven by co-morbidities and its pathophysiology is poorly understood. Several studies suggesting that dipeptidyl peptidase 4 (DPP4) might be involved in the pathophysiology of heart failure prompted experimental and clinical investigations of DPP4 inhibitors on cardiovascular system. The aim of our study was to determine whether DPP4 inhibitor sitagliptin (SITA) affects the progression of HFpEF independently from the effects on glycaemia...
December 6, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27917161/the-interaction-between-plants-and-bacteria-in-the-remediation-of-petroleum-hydrocarbons-an-environmental-perspective
#2
REVIEW
Panagiotis Gkorezis, Matteo Daghio, Andrea Franzetti, Jonathan D Van Hamme, Wouter Sillen, Jaco Vangronsveld
Widespread pollution of terrestrial ecosystems with petroleum hydrocarbons (PHCs) has generated a need for remediation and, given that many PHCs are biodegradable, bio- and phyto-remediation are often viable approaches for active and passive remediation. This review focuses on phytoremediation with particular interest on the interactions between and use of plant-associated bacteria to restore PHC polluted sites. Plant-associated bacteria include endophytic, phyllospheric, and rhizospheric bacteria, and cooperation between these bacteria and their host plants allows for greater plant survivability and treatment outcomes in contaminated sites...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27905297/altered-thermoregulatory-responses-in-heart-failure-patients-exercising-in-the-heat
#3
Bryce N Balmain, Ollie Jay, Surendran Sabapathy, Danielle Royston, Glenn M Stewart, Rohan Jayasinghe, Norman R Morris
Heart failure (HF) patients appear to exhibit impaired thermoregulatory capacity during passive heating, as evidenced by diminished vascular conductance. Although some preliminary studies have described the thermoregulatory response to passive heating in HF, responses during exercise in the heat remain to be described. Therefore, the aim of this study was to compare thermoregulatory responses in HF and controls (CON) during exercise in the heat. Ten HF (NYHA classes I-II) and eight CON were included. Core temperature (Tc), skin temperature (Tsk), and cutaneous vascular conductance (CVC) were assessed at rest and during 1 h of exercise at 60% of maximal oxygen uptake...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27879385/fio2-in-an-adult-model-simulating-high-flow-nasal-cannula-therapy
#4
Yusuke Chikata, Mutsuo Onodera, Jun Oto, Masaji Nishimura
BACKGROUND: High-flow nasal cannula therapy (HFNC) is widely used for patients with acute respiratory failure. HFNC has a number of physiological effects. Although FIO2 is considered to be constant, because HFNC is an open system, FIO2 varies according to inspiratory flow, tidal volume (VT), and HFNC gas flow. We investigated the influence of HFNC gas flow and other respiratory parameters on FIO2 during HFNC. METHODS: We evaluated an HFNC system and, for comparison, a conventional oxygen therapy system...
November 22, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27877867/electrical-and-photo-electrical-properties-of-mos2-nanosheets-with-and-without-an-al2o3-capping-layer-under-various-environmental-conditions
#5
Muhammad Farooq Khan, Ghazanfar Nazir, Volodymyr M Lermolenko, Jonghwa Eom
The electrical and photo-electrical properties of exfoliated MoS2 were investigated in the dark and in the presence of deep ultraviolet (DUV) light under various environmental conditions (vacuum, N2 gas, air, and O2 gas). We examined the effects of environmental gases on MoS2 flakes in the dark and after DUV illumination through Raman spectroscopy and found that DUV light induced red and blue shifts of peaks (E(1)2 g and A1 g) position in the presence of N2 and O2 gases, respectively. In the dark, the threshold voltage in the transfer characteristics of few-layer (FL) MoS2 field-effect transistors (FETs) remained almost the same in vacuum and N2 gas but shifted toward positive gate voltages in air or O2 gas because of the adsorption of oxygen atoms/molecules on the MoS2 surface...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27867486/effects-of-normobaric-versus-hyperbaric-oxygen-on-cell-injury-induced-by-oxygen-and-glucose-deprivation-in-acute-brain-slices
#6
Laurent Chazalviel, Jean-Eric Blatteau, Nicolas Vallée, Jean-Jacques Risso, Stéphane Besnard, Jacques H Abraini
Normobaric oxygen (NBO) and hyperbaric oxygen (HBO) are emerging as a possible co-treatment of acute ischemic stroke. Both have been shown to reduce infarct volume, to improve neurologic outcome, to promote endogenous tissue plasminogen activator-induced thrombolysis and cerebral blood flow, and to improve tissue oxygenation through oxygen diffusion in the ischemic areas, thereby questioning the interest of HBO compared to NBO. In the present study, in order to investigate and compare the oxygen diffusion effects of NBO and HBO on acute ischemic stroke independently of their effects at the vascular level, we used acute brain slices exposed to oxygen and glucose deprivation, an ex vivo model of brain ischemia that allows investigating the acute effects of NBO (partial pressure of oxygen (pO2) = 1 atmospheres absolute (ATA) = 0...
July 2016: Medical Gas Research
https://www.readbyqxmd.com/read/27859282/total-quality-index-of-agaricus-bisporus-mushrooms-packed-in-modified-atmosphere
#7
Ilija Djekic, Jovana Vunduk, Igor Tomašević, Maja Kozarski, Predrag Petrovic, Miomir Niksic, Predrag Pudja, Anita Klaus
BACKGROUND: The aim of this study was to develop a total quality index and examine the effects of modified atmosphere packaging (MAP) on the quality of Agaricus bisporus mushrooms, stored for 22 days at 4 °C. Mushrooms were packaged under three MAPs: high nitrogen packaging (HNP); low carbon dioxide packaging (LCP); and low oxygen packaging (LOP). Passive MAP with air inside initially was used as the atmosphere treatment (AIR). RESULTS: This research revealed two phases in quality deterioration of A...
November 18, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27810746/acid-rock-drainage-passive-remediation-potential-use-of-alkaline-clay-optimal-mixing-ratio-and-long-term-impacts
#8
Fernando Plaza, Yipei Wen, Hanna Perone, Yi Xu, Xu Liang
Acid rock drainage (ARD) is one of the most adverse environmental problems of the mining industry. Surface and ground water affected by this pollution are characterized by their acidity and the high content of sulfates and metals/metalloids. In this study, alkaline clay (AC), an industrial waste with a high alkalinity, which is utilized in the alumina refining process, was used as the remediation material to inhibit pyrite oxidation in waste coal piles. Through a series of laboratory experiments (static and kinetic), complemented with field measurements and geochemical modeling, three important issues associated with this passive and sustainable ARD remediation method were investigated: 1) the potential use of alkaline clay as an ARD remediation material, 2) the adequate alkaline clay/coal refuse mixing ratio (AC/CR) to ensure pH values close to neutral conditions, and, 3) the implications for long-term performance, in terms of the trends of the main parameters involved in this process such as pH, concentrations of sulfate, iron and other dissolved contaminants...
October 27, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27807528/postprandial-lipoprotein-profile-in-two-modes-of-high-intensity-intermittent-exercise
#9
Valéria Leme Gonçalves Panissa, Ursula Ferreira Julio, Tiego Aparecido Diniz, Barbara de Moura Mello Antunes, Fabio Santos Lira, Monica Yuri Takito, Emerson Franchini
The aim of present study was to compare blood lipid postprandial profile response in two modes of high-intensity intermittent exercise. Twelve individuals (6 men and 6 women) were submitted to a maximal incremental test (to determine maximal aerobic power [MAP] and V. O2peak [peak oxygen uptake]), high-intensity intermittent all-out exercise (60×8-sec bouts interspersed by 12-sec passive recovery) and fixed high-intensity intermittent exercise (100% maximal aerobic speed, consisted of 1-min repetitions at MAP [70 rpm] separated by 1-min of passive recovery)...
October 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/27805186/band-alignment-and-depletion-zone-at-zno-cds-and-zno-cdse-hetero-structures-for-temperature-independent-ammonia-vapor-sensing
#10
N Rajeswari Yogamalar, K Sadhanandham, A Chandra Bose, R Jayavel
An optical-fiber based evanescent ammonia vapor sensor was constructed with surface-passivated growth of zinc oxide (ZnO) nanostructures, which was achieved through a three-step wet chemical process. Initially, the ZnO nanostructures were synthesized using a wet-chemical method and subsequently surface-passivated with chalcogenide material compounds namely cadmium sulphide (CdS) and cadmium selenide (CdSe) nanoparticles individually using a citric acid assisted chemical synthesis technique. Finally, surface-passivated ZnO was deposited on the cladding modified optical-fiber using a dip coating process...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27786541/postexercise-cold-water-immersion-improves-intermittent-high-intensity-exercise-performance-in-normothermia
#11
Avina McCarthy, James Mulligan, Mikel Egaña
A brief cold water immersion between 2 continuous high-intensity exercise bouts improves the performance of the latter compared with passive recovery in the heat. We investigated if this effect is apparent in normothermic conditions (∼19 °C), employing an intermittent high-intensity exercise designed to reflect the work performed at the high-intensity domain in team sports. Fifteen young active men completed 2 exhaustive cycling protocols (Ex1 and Ex2: 12 min at 85% ventilatory threshold (VT) and then an intermittent exercise alternating 30-s at 40% peak power (Ppeak) and 30 s at 90% Ppeak to exhaustion) separated by 15 min of (i) passive rest, (ii) 5-min cold-water immersion at 8 °C, and (iii) 10-min cold-water immersion at 8 °C...
July 25, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27759005/heme-biomolecule-as-redox-mediator-and-oxygen-shuttle-for-efficient-charging-of-lithium-oxygen-batteries
#12
Won-Hee Ryu, Forrest S Gittleson, Julianne M Thomsen, Jinyang Li, Mark J Schwab, Gary W Brudvig, André D Taylor
One of the greatest challenges with lithium-oxygen batteries involves identifying catalysts that facilitate the growth and evolution of cathode species on an oxygen electrode. Heterogeneous solid catalysts cannot adequately address the problematic overpotentials when the surfaces become passivated. However, there exists a class of biomolecules which have been designed by nature to guide complex solution-based oxygen chemistries. Here, we show that the heme molecule, a common porphyrin cofactor in blood, can function as a soluble redox catalyst and oxygen shuttle for efficient oxygen evolution in non-aqueous Li-O2 batteries...
October 19, 2016: Nature Communications
https://www.readbyqxmd.com/read/27749047/stimulus-responsive-prochelators-for-manipulating-cellular-metals
#13
Qin Wang, Katherine J Franz
Metal ions are essential for a wide range of physiological processes, but they can also be toxic if not appropriately regulated by a complex network of metal trafficking proteins. Intervention in cellular metal distribution with small-molecule or peptide chelating agents has promising therapeutic potential to harness metals to fight disease. Molecular outcomes associated with forming metal-chelate interactions in situ include altering the concentration and subcellular metal distribution, inhibiting metalloenzymes, enhancing the reactivity of a metal species to elicit a favorable biological response, or passivating the reactivity of a metal species to prevent deleterious reactivity...
October 17, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27747393/exercise-effects-in-huntington-disease
#14
Sebastian Frese, Jens A Petersen, Maria Ligon-Auer, Sandro Manuel Mueller, Violeta Mihaylova, Saskia M Gehrig, Veronika Kana, Elisabeth J Rushing, Evelyn Unterburger, Georg Kägi, Jean-Marc Burgunder, Marco Toigo, Hans H Jung
Huntington disease (HD) is a relentlessly progressive neurodegenerative disorder with symptoms across a wide range of neurological domains, including cognitive and motor dysfunction. There is still no causative treatment for HD but environmental factors such as passive lifestyle may modulate disease onset and progression. In humans, multidisciplinary rehabilitation has a positive impact on cognitive functions. However, a specific role for exercise as a component of an environmental enrichment effect has been difficult to demonstrate...
October 17, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27738996/the-neural-correlates-of-lexical-processing-in-disorders-of-consciousness
#15
Anna Nigri, Eleonora Catricalà, Stefania Ferraro, Maria Grazia Bruzzone, Ludovico D'Incerti, Davide Sattin, Davide Rossi Sebastiano, Silvana Franceschetti, Giorgio Marotta, Riccardo Benti, Matilde Leonardi, Stefano F Cappa
There is a growing interest in the use of functional imaging to assess brain activity in the absence of behavioural responses in patients with disorders of consciousness (DOC). In the present study, we applied a hierarchical auditory stimulation paradigm to functional magnetic resonance (fMRI) in a group of long-term DOC adult patients. Brain response to pairs of pseudowords, of unrelated words and of semantically related words, i.e. stimuli differing in lexical status (words vs. pseudowords) and semantic relatedness (related vs...
October 13, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27709512/neural-correlates-of-immediate-and-prolonged-effects-of-cognitive-reappraisal-and-distraction-on-emotional-experience
#16
Andrea Hermann, Laura Kress, Rudolf Stark
Cognitive emotion regulation strategies are important components of cognitive-behavioral therapy (CBT). Additionally, up-regulation and difficulties in the down-regulation of negative feelings are associated with mental disorders. However, little is known about the lasting effects of cognitive emotion regulation strategies on emotional experience and associated neural activation. Therefore, this study investigated immediate and prolonged effects of emotion regulation using cognitive reappraisal and distraction on subjective report and its neural correlates...
October 5, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27707964/functional-subdomains-within-scene-selective-cortex-parahippocampal-place-area-retrosplenial-complex-and-occipital-place-area
#17
Tolga Çukur, Alexander G Huth, Shinji Nishimoto, Jack L Gallant
: Functional MRI studies suggest that at least three brain regions in human visual cortex-the parahippocampal place area (PPA), retrosplenial complex (RSC), and occipital place area (OPA; often called the transverse occipital sulcus)-represent large-scale information in natural scenes. Tuning of voxels within each region is often assumed to be functionally homogeneous. To test this assumption, we recorded blood oxygenation level-dependent responses during passive viewing of complex natural movies...
October 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27696859/vacancy-induced-semiconductor-insulator-metal-transitions-in-non-stoichiometric-nickel-and-tungsten-oxides
#18
Qi Wang, Ajinkya Puntambekar, Vidhya Chakrapani
Metal-insulator transitions in strongly correlated oxides induced by electrochemical charging have been attributed to formation of vacancy defects. However, the role of native defects in affecting these transitions is not clear. Here, we report a new type of phase transition in p-type, non-stoichiometric nickel oxide involving a semiconductor-to-insulator-to-metal transition along with the complete reversal of conductivity from p- to n-type at room temperature induced by electrochemical charging in a Li+-containing electrolyte...
October 3, 2016: Nano Letters
https://www.readbyqxmd.com/read/27696834/combining-leaching-and-passive-sampling-to-measure-the-mobility-and-distribution-between-porewater-doc-and-colloids-of-native-oxy-pahs-n-pacs-and-pahs-in-historically-contaminated-soil
#19
Anja Enell, Staffan Lundstedt, Hans Peter H Arp, Sarah Josefsson, Gerard Cornelissen, Ola Wik, Dan Berggren Kleja
Different methods to quantify soil porewater concentrations of contaminants will provide different types of information. Passive sampling measurements give freely dissolved porewater concentrations (Cpw,free), while leaching tests provide information on the mobile concentration (Cpw,leach), including contaminants associated to dissolved organic carbon (DOC) and particles/colloids in the porewater. This study presents a novel combination of these two measurements, to study the sorption and mobility of polycyclic aromatic compounds (PACs)) to DOC and particulate organic carbon (POC) in 10 historically contaminated soils...
October 3, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27695529/oxidation-reduction-potential-of-semen-what-is-its-role-in-the-treatment-of-male-infertility
#20
Ashok Agarwal, Shubhadeep Roychoudhury, Kimberly B Bjugstad, Chak-Lam Cho
The diagnosis of male infertility relies largely on conventional semen analysis, and its interpretation has a profound influence on subsequent management of patients. Despite poor correlation between conventional semen parameters and male fertility potential, inclusion of advanced semen quality tests to routine male infertility workup algorithms has not been widely accepted. Oxidative stress is one of the major mediators in various etiologies of male infertility; it has deleterious effects on spermatozoa, including DNA damage...
October 2016: Therapeutic Advances in Urology
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