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https://www.readbyqxmd.com/read/29452131/synergism-between-a-cell-penetrating-peptide-and-a-ph-sensitive-cationic-lipid-in-efficient-gene-delivery-based-on-double-coated-nanoparticles
#1
Ikramy A Khalil, Seigo Kimura, Yusuke Sato, Hideyoshi Harashima
We report on the development of a highly efficient gene delivery system based on synergism between octaarginine (R8), a representative cell penetrating peptide, and YSK05, a recently developed pH-sensitive cationic lipid. Attaching a high density of R8 on the surface of YSK05 nanoparticles (NPs) that contained encapsulated plasmid DNA resulted in the formation of positively charged NPs with improved transfection efficiency. To avoid the development of a net positive charge, we controlled the density and topology of the R8 peptide through the use of a two-step coating methodology, in which the inner lipid coat was modified with a low density of R8 which was then covered with an outer neutral YSK05 lipid layer...
February 13, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29452074/differential-control-of-appetitive-and-consummatory-sexual-behavior-by-neuroestrogens-in-male-quail
#2
REVIEW
Charlotte A Cornil, Gregory F Ball, Jacques Balthazart
Estrogens exert pleiotropic effects on multiple physiological and behavioral traits including sexual behavior. These effects are classically mediated via binding to nuclear receptors and subsequent regulation of target gene transcription. Estrogens also affect neuronal activity and cell-signaling pathways via faster, membrane-initiated events. Although the distinction between appetitive and consummatory aspects of sexual behavior has been criticized, this distinction remains valuable in that it facilitates the causal analysis of certain behavioral systems...
February 13, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29451406/cancer-costs-and-outcomes-for-common-cancer-sites-in-the-finnish-population-between-2009-2014
#3
Paulus Torkki, Riikka-Leena Leskelä, Miika Linna, Suvi Mäklin, Jukka-Pekka Mecklin, Petri Bono, Vesa Kataja, Sakari Karjalainen
BACKGROUND: The cost of cancer and outcomes of cancer care have been discussed a lot since cancer represents 3-6% of total healthcare costs and cost estimations have indicated growing costs. There are studies considering the cost of all cancers, but studies focusing on the cost of disease and outcomes in most common cancer sites are limited. The objective of this study was to analyze the development of the costs and outcomes in Finland between 2009 and 2014 per cancer site. METHODS: The National cost, episode and outcomes data were obtained from the National register databases based on International Statistical Classification of Diseases (ICD)-10 diagnosis codes...
February 16, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29449884/improved-photobio-h-2-production-regulated-by-artificial-mirna-targeting-psba-in-green-microalga-chlamydomonas-reinhardtii
#4
Hui Li, Yanmei Liu, Yuting Wang, Meirong Chen, Xiaoshan Zhuang, Chaogang Wang, Jiangxin Wang, Zhangli Hu
Background: Sulfur-deprived cultivation of Chlamydomonas reinhardtii , referred as "two-stage culture" transferring the cells from regular algal medium to sulfur-deplete one, has been extensively studied to improve photobio-H 2 production in this green microalga. During sulfur-deprivation treatment, the synthesis of a key component of photosystem II complex, D1 protein, was inhibited and improved photobio-H 2 production could be established in C. reinhardtii . However, separation of algal cells from a regular liquid culture medium to a sulfur-deprived one is not only a discontinuous process, but also a cost- and time-consuming operation...
2018: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29449672/electromagnetically-induced-polarization-grating
#5
Lu Zhao
Based on electromagnetically induced transparency (EIT), we investigate an all-optical grating structure to realize polarization-dependent multiple beam splitting in the Raman-Nath limit. To optimize the grating performance, higher excited state [e.g., nS 1/2 (n ≥ 6)] of ultracold 87 Rb atoms is employed to construct a five-level Ξ-Λ system sharing one common populated ground state. A principal advantage of our proposed scheme is that the σ ± components of a linearly polarized weak probe field can be decoupled and thus be independently diffracted with high efficiency in both one and two dimensions by exploiting different quasi-standing waves as the two strong coupling fields in the Ξ and Λ configurations...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448463/effective-equilibrium-states-in-mixtures-of-active-particles-driven-by-colored-noise
#6
René Wittmann, J M Brader, A Sharma, U Marini Bettolo Marconi
We consider the steady-state behavior of pairs of active particles having different persistence times and diffusivities. To this purpose we employ the active Ornstein-Uhlenbeck model, where the particles are driven by colored noises with exponential correlation functions whose intensities and correlation times vary from species to species. By extending Fox's theory to many components, we derive by functional calculus an approximate Fokker-Planck equation for the configurational distribution function of the system...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448402/nonreciprocity-in-the-dynamics-of-coupled-oscillators-with-nonlinearity-asymmetry-and-scale-hierarchy
#7
Keegan J Moore, Jonathan Bunyan, Sameh Tawfick, Oleg V Gendelman, Shuangbao Li, Michael Leamy, Alexander F Vakakis
In linear time-invariant dynamical and acoustical systems, reciprocity holds by the Onsager-Casimir principle of microscopic reversibility, and this can be broken only by odd external biases, nonlinearities, or time-dependent properties. A concept is proposed in this work for breaking dynamic reciprocity based on irreversible nonlinear energy transfers from large to small scales in a system with nonlinear hierarchical internal structure, asymmetry, and intentional strong stiffness nonlinearity. The resulting nonreciprocal large-to-small scale energy transfers mimic analogous nonlinear energy transfer cascades that occur in nature (e...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448372/quantum-theory-for-the-dynamic-structure-factor-in-correlated-two-component-systems-in-nonequilibrium-application-to-x-ray-scattering
#8
J Vorberger, D A Chapman
We present a quantum theory for the dynamic structure factors in nonequilibrium, correlated, two-component systems such as plasmas or warm dense matter. The polarization function, which is needed as the input for the calculation of the structure factors, is calculated in nonequilibrium based on a perturbation expansion in the interaction strength. To make our theory applicable for x-ray scattering, a generalized Chihara decomposition for the total electron structure factor in nonequilibrium is derived. Examples are given and the influence of correlations and exchange on the structure and the x-ray-scattering spectrum are discussed for a model nonequilibrium distribution, as often encountered during laser heating of materials, as well as for two-temperature systems...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29448161/how-does-lower-limb-dominance-influence-postural-control-movements-during-single-leg-stance
#9
Arunee Promsri, Thomas Haid, Peter Federolf
The main purposes of the current study were to examine bilateral asymmetry in postural control during single-leg standing between the dominant and non-dominant legs using a novel analysis approach based on principal component analysis (PCA). It was hypothesized that the asymmetry might manifest as differences in the coordinative structure (control strategies), or as differences in the frequency or regularity of corrective interventions of the motor control system. The static and dynamic leg dominance of 26 active young adults (14 males and 12 females) was determined from their preferred leg for dynamic and for static tasks...
February 12, 2018: Human Movement Science
https://www.readbyqxmd.com/read/29447975/profiling-of-novel-micrornas-elicited-by-ev71-and-ca16-infection-in-human-bronchial-epithelial-cells-using-high-throughput-sequencing
#10
Jie Song, Yajie Hu, Xi Jiang, Wenbing Zhu, Zhongxiang Wu, Shaozhong Dong
Enterovirus 71 (EV71) and coxsackievirus A16 (CA16) are two major etiologic agents associated with hand, foot, and mouth disease (HFMD) worldwide. Despite that they both belong to the Enterovirus genus of the Picornaviridae family, there are many differences in the infection process of these viruses. However, the underlying mechanisms have not been elucidated. Multiple studies indicated that microRNAs (miRNAs) can play critical roles in the host-pathogen interaction. Our previous study reported that EV71 and CA16 infection leads to differential expression of miRNAs in human bronchial epithelial (16HBE) cells...
February 12, 2018: Virus Research
https://www.readbyqxmd.com/read/29447447/dl_mg-a-parallel-multigrid-poisson-and-poisson-boltzmann-solver-for-electronic-structure-calculations-in-vacuum-and-solution
#11
James C Womack, Lucian Anton, Jacek Dziedzic, Philip J Hasnip, Matthew Ian James Probert, Chris-Kriton Skylaris
The solution of the Poisson equation is a crucial step in electronic structure calculations, yielding the electrostatic potential-a key component of the quantum mechanical Hamiltonian. In recent decades, theoretical advances and increases in computer performance have made it possible to simulate the electronic structure of extended systems in complex environments. This requires the solution of more complicated variants of the Poisson equation, featuring nonhomogeneous dielectric permittivities, ionic concentrations with non-linear dependencies, and diverse boundary conditions...
February 15, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29447403/assessment-of-data-quality-and-reporting-systems-for-underserved-populations-the-case-of-integrated-community-case-management-programs-in-nigeria
#12
Florence M Nyangara, Tajrina Hai, Kirsten Zalisk, Lynda Ozor, Joy Ufere, Chinwoke Isiguzo, Ibrahim Ndaliman Abubakar
Decision makers are searching for reliable data and best practices to support the implementation and scale-up of the integrated community case management (iCCM) programs in underserved areas to reduce under-five mortality in low-income countries. This study assesses data quality and reporting systems of the World Health Organization supported Rapid Access Expansion program implementing iCCM in Abia and Niger States, Nigeria. This cross-sectional study used data from 16 primary health facilities in both states...
February 13, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29446726/metal-organic-framework-mof-based-nanomaterials-for-biomedical-applications
#13
Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Baohong Li, Jianqiang Liu
Metal-organic frameworks (MOFs) are compounds consisting of metal ions or clusters coordinated to organic ligands to form one-, two-, or three-dimensional structures. They are a subclass of coordination polymers (CPs), with the special feature that they are often porous. The organic ligands are sometimes referred to as second building structs. The new porous materials have paid great attention because of the variety of advantages such as tunable components, structural diversity, high loading performance and favorable biodegradability...
February 14, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29446456/lack-of-mitochondrial-thioredoxin-o1-is-compensated-by-antioxidant-components-under-salinity-in-arabidopsis-thaliana-plants
#14
Aingeru Calderón, Antonio Sánchez-Guerrero, Ana Ortiz-Espín, Isabel Martínez-Alcalá, Daymi Camejo, Ana Jiménez, Francisca Sevilla
In a changing environment, plants are able to acclimate to the new conditions by regulating their metabolism through the antioxidant and redox systems involved in the stress response. Here we studied a mitochondrial thioredoxin in wild type (WT) Arabidopis thaliana and two Attrxo1 mutant lines grown in the absence or presence of 100 mM NaCl. Compared to WT plants, no evident phenotype was observed in the mutant plants in control condition, although they had higher number of stomata, loss of water, nitric oxide and carbonyl protein contents as well as higher activity of superoxide dismutase (SOD) and catalase enzymes than WT plants...
February 15, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29445517/autonomic-components-of-complex-regional-pain-syndrome-crps-are-favourably-affected-by-electrical-twitch-obtaining-intramuscular-stimulation-etoims-effects-on-blood-pressure-and-heart-rate
#15
Jennifer Chu, Frans Bruyninckx, Duncan V Neuhauser
Introduction: Favourable pain relief results on evoking autonomous twitches at myofascial trigger points with Electrical Twitch Obtaining Intramuscular Stimulation (ETOIMS). Aim: To document autonomic nervous system (ANS) dysfunction in Complex Regional Pain Syndrome (CRPS) from blood pressure (BP) and pulse/heart rate changes with ETOIMS. Methods and materials: A patient with persistent pain regularly received serial ETOIMS sessions of 60, 90, 120 or ≥150 min over 24 months...
July 2017: BMJ Innovations
https://www.readbyqxmd.com/read/29445382/innovative-approaches-to-evaluate-sugar-beet-responses-to-changes-in-sulfate-availability
#16
Piergiorgio Stevanato, Chiara Broccanello, Vita M C Moliterni, Giuseppe Mandolino, Valeria Barone, Luigi Lucini, Giovanni Bertoldo, Marco Bertaggia, Massimo Cagnin, Diego Pizzeghello, Andrea Baglieri, Andrea Squartini, Giuseppe Concheri, Serenella Nardi
In this study, a system based on omics profiling was set-up for sugar beet ( Beta vulgaris L. subsp. vulgaris ) evaluation after changes in sulfate availability. Seedlings were grown on sulfate-deprived Hoagland solution. Six days after germination, 100 μM MgSO 4 was added to the solution. Root samples were collected 36 h after treatments. WinRHIZO root-scanning approach was used for the automated image analysis of plant root morphology. Inductively Coupled Plasma Spectrometry (ICP-OES) and quadrupole-time-of-flight mass spectrometry (Q-TOF) were used for ionomic and metabolic analysis, respectively...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29445020/trade-offs-between-microbial-growth-phases-lead-to-frequency-dependent-and-non-transitive-selection
#17
Michael Manhart, Bharat V Adkar, Eugene I Shakhnovich
Mutations in a microbial population can increase the frequency of a genotype not only by increasing its exponential growth rate, but also by decreasing its lag time or adjusting the yield (resource efficiency). The contribution of multiple life-history traits to selection is a critical question for evolutionary biology as we seek to predict the evolutionary fates of mutations. Here we use a model of microbial growth to show that there are two distinct components of selection corresponding to the growth and lag phases, while the yield modulates their relative importance...
February 14, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29444844/the-stomatogastric-nervous-system-of-the-medicinal-leech-its-anatomy-physiology-and-associated-aminergic-neurons
#18
Karen A Mesce, Magda Alania, Quentin Gaudry, Joshua G Puhl
Blood feeding is an essential and signature activity of the medicinal leech species, Hirudo verbana Despite keen interest in understanding the neuronal substrates of this behavior, a major component of the nervous system associated with feeding has remained overlooked. In this study, for the first time, we report on the presence and characteristics of five stomatogastic ganglia (STGs) comprising the visceral stomatogastric nervous system (STN) of the leech. Although Hanke (1948) provided a brief report that a ring of three ganglia (not five) was associated with the cephalic ganglia, this information was never integrated into subsequent neurobiological studies of feeding...
February 14, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29444538/-effects-of-judo-specific-resistance-training-on-kinetic-and-electromyographic-parameters-of-pulling-exercises-in-judo-athletes
#19
Norman Helm, Olaf Prieske, Thomas Muehlbauer, Tom Krüger, Urs Granacher
BACKGROUND: In judo, rapid force production during pulling movements is an important component of athletic performance, which is why this capacity needs to be specifically exercised in judo. This study aimed at examining the effects of a judo-specific resistance training program using a judo ergometer system (PTJ) versus a traditional resistance training regime using a partner (PTP) on kinetics and muscle activity of judo-specific pulling exercises. METHOD: Twenty-four male judo athletes (age: 22 ± 4 years, training experience: 15 ± 3 years) were randomly assigned to two groups...
February 14, 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29444418/circuitry-rewiring-directly-couples-competence-to-predation-in-the-gut-dweller-streptococcus-salivarius
#20
Johann Mignolet, Laetitia Fontaine, Andrea Sass, Catherine Nannan, Jacques Mahillon, Tom Coenye, Pascal Hols
Small distortions in transcriptional networks might lead to drastic phenotypical changes, especially in cellular developmental programs such as competence for natural transformation. Here, we report a pervasive circuitry rewiring for competence and predation interplay in commensal streptococci. Canonically, in streptococci paradigms such as Streptococcus pneumoniae and Streptococcus mutans, the pheromone-based two-component system BlpRH is a central node that orchestrates the production of antimicrobial compounds (bacteriocins) and incorporates signal from the competence activation cascade...
February 13, 2018: Cell Reports
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