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Alpha-1-acid glycoprotein

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https://www.readbyqxmd.com/read/29908956/complement-activation-in-acute-myocardial-infarction-an-early-marker-of-inflammation-and-tissue-injury
#1
Lorena Bavia, Kárita Cláudia Freitas Lidani, Fabiana Antunes Andrade, Miguel Ibraim Abboud Hanna Sobrinho, Renato Mitsunori Nisihara, Iara Jose de Messias-Reason
BACKGROUND: Acute myocardial infarction (AMI) is a potentially fatal condition, being a major cause of death worldwide. Ischemia suffered during AMI causes tissue damage, leading to an inflammatory process. Moreover, myocardial injury can generate damage-associated molecular patterns that activate pattern recognition molecules including some complement proteins. METHODS: Here we investigated products of complement activation, C3d and soluble C5b9 (sC5b9), as potential biomarkers for myocardial injury and inflammation, as well as serum cytokines (IL-6 and TNF-alpha), alpha-1-acid glycoprotein (AGP), and classical markers of myocardial necrosis (creatine kinase, creatine kinase-MB isoform, myoglobin and troponin-I) in a longitudinal study of patients with AMI (from admission, 6 h and 12 h post admission, and at discharge from hospital)...
June 14, 2018: Immunology Letters
https://www.readbyqxmd.com/read/29889556/urinary-alpha-1-acid-glycoprotein-is-a-sensitive-marker-of-glomerular-protein-leakage-at-altitude
#2
Ben J Talks, Susie B Bradwell, John Delamere, Will Rayner, Alex Clarke, Chris T Lewis, Owen D Thomas, Arthur R Bradwell
Talks, Ben J., Susie B. Bradwell, John Delamere, Will Rayner, Alex Clarke, Chris T. Lewis, Owen D. Thomas, and Arthur R. Bradwell. Urinary alpha-1-acid glycoprotein is a sensitive marker of glomerular protein leakage at altitude. High Alt Med Biol 00:000-000, 2018. Proteinuria is an established feature of ascent to altitude and may be caused by a loss of negative charges on glomerular capillary walls (GCWs). To test this hypothesis, we measured two similar sized but oppositely charged proteins in urine: negatively charged alpha-1-acid glycoprotein (α1-AGP, 41-43 kDa) and positively charged dimeric lambda free light chains (λ-FLCs, 50 kDa)...
June 11, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29675569/effect-of-zinc-sulfate-and-zinc-glycine-chelate-on-concentrations-of-acute-phase-proteins-in-chicken-serum-and-liver-tissue
#3
Łukasz Jarosz, Agnieszka Marek, Zbigniew Grądzki, Ewa Laskowska, Małgorzata Kwiecień
The aim of the study was to determine how inorganic and organic forms of zinc affect the concentrations of C-reactive protein (CRP), serum amyloid A (SAA), alpha-1-acid glycoprotein (α-1-AGP), haptoglobin (Hp), and transferrin (TRF) in the blood and liver tissue of 450 1-day-old Ross 308 chicken. Four experimental groups received one the following: inorganic zinc (ZnSO4 ), a zinc phytase enzyme supplement (ZnSO4 -F), organic zinc in combination with glycine (Zn-Gly), or organic zinc supplemented with phytase (Zn-Gly-F)...
April 19, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29669491/biophysical-insights-into-the-interaction-of-clofazimine-with-human-alpha-1-acid-glycoprotein-a-multitechnique-approach
#4
Mohammad Rehan Ajmal, Fahad Almutairi, Nida Zaidi, Parvez Alam, Mohammad Khursheed Siddiqi, Mohsin Vahid Khan, Masihuz Zaman, Mohd Ishtikhar, Rizwan Hasan Khan
Alpha1-acid glycoprotein (AAG) is a major acute phase protein of human plasma. Binding of clofazimine to AAG is investigated using optical spectroscopy and molecular docking tools. We found significant quenching of intrinsic fluorescence of AAG upon the binding of clofazimine, binding mode is static with binding constant of 3.52 × 104 at 298 K. The Gibbs free energy change is found to be negative for the interaction of clofazimine with AAG indicating spontaneity of the binding process. Binding of clofazimine induced ordered structure in protein and lead to molecular compaction...
April 25, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29613921/markers-of-environmental-enteric-dysfunction-are-associated-with-neurodevelopmental-outcomes-in-tanzanian-children
#5
Analee J Etheredge, Karim Manji, Mark Kellogg, Hao Tran, Enju Liu, Christine M McDonald, Rodrick Kisenge, Said Aboud, Wafaie Fawzi, David Bellinger, Andrew T Gewirtz, Christopher P Duggan
BACKGROUND: Chronic exposure to enteropathogens may result in environmental enteric dysfunction (EED), a subclinical condition associated with poor child growth. Growth faltering is strongly associated with poor neurodevelopment, and occurs during sensitive periods of postnatal brain development. We investigated the role of novel EED biomarkers, systemic inflammation, and micronutrient status on neurodevelopment in Tanzanian children. METHODS: Non-stunted subjects with 6-week and 6-month blood samples and neurodevelopmental measures (n = 107) were included in this study...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29607540/melatonin-improves-insulin-resistance-and-hepatic-steatosis-through-attenuation-of-alpha-2-hs-glycoprotein
#6
Jee-In Heo, Dae Wui Yoon, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim
Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA), are one of the hepatokines and are known to be associated with insulin resistance and type 2 diabetes. The aim of this study was to determine whether melatonin improves hepatic insulin resistance and hepatic steatosis in a FETUA-dependent manner...
April 1, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29556050/versatile-protein-recognition-by-the-encoded-display-of-multiple-chemical-elements-on-a-constant-macrocyclic-scaffold
#7
Yizhou Li, Roberto De Luca, Samuele Cazzamalli, Francesca Pretto, Davor Bajic, Jörg Scheuermann, Dario Neri
In nature, specific antibodies can be generated as a result of an adaptive selection and expansion of lymphocytes with suitable protein binding properties. We attempted to mimic antibody-antigen recognition by displaying multiple chemical diversity elements on a defined macrocyclic scaffold. Encoding of the displayed combinations was achieved using distinctive DNA tags, resulting in a library size of 35,393,112. Specific binders could be isolated against a variety of proteins, including carbonic anhydrase IX, horseradish peroxidase, tankyrase 1, human serum albumin, alpha-1 acid glycoprotein, calmodulin, prostate-specific antigen and tumour necrosis factor...
April 2018: Nature Chemistry
https://www.readbyqxmd.com/read/29518400/quantitative-estimation-of-plasma-free-drug-fraction-in-patients-with-varying-degrees-of-hepatic-impairment-a-methodological-evaluation
#8
Guo-Fu Li, Guo Yu, Yanfei Li, Yi Zheng, Qing-Shan Zheng, Hartmut Derendorf
Quantitative prediction of unbound drug fraction (fu ) is essential for scaling pharmacokinetics through physiologically based approaches. However, few attempts have been made to evaluate the projection of fu values under pathological conditions. The primary objective of this study was to predict fu values (n = 105) of 56 compounds with or without the information of predominant binding protein in patients with varying degrees of hepatic insufficiency by accounting for quantitative changes in molar concentrations of either the major binding protein or albumin plus alpha 1-acid glycoprotein associated with differing levels of hepatic dysfunction...
March 6, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29475030/screening-for-protein-adducts-of-naphthalene-and-chrysene-in-plasma-of-exposed-atlantic-cod-gadus-morhua
#9
Karianne S Enerstvedt, Magne O Sydnes, Eivind Larssen, Daniela M Pampanin
Polycyclic aromatic hydrocarbons (PAHs) are well known contaminants, ubiquitously present in the habitat and spawning areas for Atlantic cod (Gadus morhua). The Atlantic cod is a key species and a globally important food source, thus continuous monitoring of PAHs is considered highly valuable to ensure ecosystem sustainability and human food safety. PAH adducts to plasma proteins are applied as sensitive biomarkers of PAH exposure in humans and other species, thus the presence of PAH protein adducts in Atlantic cod plasma was investigated to identify PAH protein adduct biomarker candidates of exposure to PAHs...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29462352/inhibition-of-corticosterone-synthesis-and-its-effect-on-acute-phase-proteins-heat-shock-protein-70-and-interleukin-6-in-broiler-chickens-subjected-to-feed-restriction
#10
P Najafi, I Zulkifli, A F Soleimani
The aim of the current study was to elucidate whether inhibition of corticosterone (CORT) synthesis could modify stress response to feed deprivation and its possible interactions with feed restriction in the neonatal period in broiler chickens. Equal numbers of broiler chicks were subjected to either 60% feed restriction (60FR) or ad libitum (AL) on d 4, 5, and 6. On day 7, blood CORT, acute phase proteins (APP), interleukin-6 (IL-6) levels, and brain heat shock protein 70 (HSP70) expression were determined...
April 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29405331/the-analysis-of-alpha-1-antitrypsin-glycosylation-with-direct-lc-ms-ms
#11
Haidi Yin, Mingrui An, Pui-Kin So, Melody Yee-Man Wong, David M Lubman, Zhongping Yao
A liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based methodology has been developed to differentiate core- and antennary-fucosylated glycosylation of glycopeptides. Both the glycosylation sites (heterogeneity) and multiple possible glycan occupancy at each site (microheterogeneity) can be resolved via intact glycopeptide analysis. The serum glycoprotein alpha-1-antitrypsin (A1AT) which contains both core- and antennary-fucosylated glycosites was used in this study. Sialidase was used to remove the sialic acids in order to simplify the glycosylation microheterogeneity and to enhance the MS signal of glycopeptides with similar glycan structures...
February 5, 2018: Electrophoresis
https://www.readbyqxmd.com/read/29381776/effects-of-low-protein-diets-on-acute-phase-proteins-and-heat-shock-protein-70-responses-and-growth-performance-in-broiler-chickens-under-heat-stress-condition
#12
I Zulkifli, A F Akmal, A F Soleimani, M A Hossain, E A Awad
A study with a 4 × 2 factorial arrangement was conducted to investigate the effects of 4 dietary protein levels and 2 environmental conditions on acute phase proteins (APP), brain heat shock protein (HSP) 70 density, and growth performance of broiler chickens. Day-old broiler chicks (Cobb 500) were fed isocaloric diets but with various levels of crude protein (CP), namely, (1) 21.0 and 19.0% CP in starter and finisher diets, respectively (control), (2) 19.5 and 17.5% CP in starter and finisher diets, respectively (Diet A), (3) 18...
April 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29332802/total-%C3%AE-1-acid-glycoprotein-determination-in-serum-samples-using-disposable-screen-printed-electrodes-and-osmium-vi-as-electrochemical-tag
#13
Tania Sierra, María Cristina González, Begoña Moreno, Agustin G Crevillen, Alberto Escarpa
Alpha-1-acid glycoprotein (AGP) or Orosomucoid is a serum glycoprotein which belongs to the group of acute phase proteins. It is a potential biomarker for inflammatory bowel diseases. In this sense, there is a need for developing fast and cheap analytical methods for diagnosis, prognosis and follow-up of these diseases. In this work, we propose a simple and cheap electrochemical method for total AGP determination using disposable carbon screen-printed electrodes (SPE) and using a selective acidic precipitation of the rest of proteins...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29316198/co-causation-of-reduced-newborn-size-by-maternal-undernutrition-infections-and-inflammation
#14
Per Ashorn, Lotta Hallamaa, Lindsay H Allen, Ulla Ashorn, Upeksha Chandrasiri, Megan Deitchler, Ronan Doyle, Ulla Harjunmaa, Josh M Jorgensen, Steve Kamiza, Nigel Klein, Kenneth Maleta, Minyanga Nkhoma, Brietta M Oaks, Basho Poelman, Stephen J Rogerson, Christine P Stewart, Mamane Zeilani, Kathryn G Dewey
More than 20 million babies are born with low birthweight annually. Small newborns have an increased risk for mortality, growth failure, and other adverse outcomes. Numerous antenatal risk factors for small newborn size have been identified, but individual interventions addressing them have not markedly improved the health outcomes of interest. We tested a hypothesis that in low-income settings, newborn size is influenced jointly by multiple maternal exposures and characterized pathways associating these exposures with newborn size...
January 8, 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29234088/tear-proteome-analysis-in-ocular-surface-diseases-using-label-free-lc-ms-ms-and-multiplexed-microarray-biomarker-validation
#15
Javier Soria, Arantxa Acera, Jesús Merayo-LLoves, Juan A Durán, Nerea González, Sandra Rodriguez, Nikitas Bistolas, Soeren Schumacher, Frank F Bier, Harald Peter, Walter Stöcklein, Tatiana Suárez
We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals. Of these, 37 samples were analyzed using spectral-counting-based LC-MS/MS label-free quantitation, and 33 samples were evaluated in the validation of candidate biomarkers employing customized antibody microarray assays. Comparative analysis of tear protein profiles revealed differences in the expression levels of 26 proteins, including protein S100A6, annexin A1, cystatin-S, thioredoxin, phospholipase A2, antileukoproteinase, and lactoperoxidase...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231704/site-specific-glycan-heterogeneity-characterization-by-hydrophilic-interaction-liquid-chromatography-solid-phase-extraction-reversed-phase-liquid-chromatography-fractionation-and-capillary-zone-electrophoresis-electrospray-ionization-tandem-mass-spectrometry
#16
Yanyan Qu, Liangliang Sun, Zhenbin Zhang, Norman J Dovichi
Reversed-phase chromatographic separation of glycopeptides tends to be dominated by the peptide composition. In contrast, capillary zone electrophoresis separation of glycopeptides is particularly sensitive to the sialic acid composition of the glycan. In this paper, we combine the two techniques to achieve superior N-glycopeptide analysis. Glycopeptides were first isolated from a tryptic digest using hydrophilic interaction liquid chromatography (HILIC) solid-phase extraction. The glycopeptides were separated using reversed-phase ultra high-performance liquid chromatography (UHPLC) to generate four fractions corresponding to different peptide backbones...
January 16, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29230915/periapical-infection-may-affect-birth-outcomes-via-systemic-inflammation
#17
U Harjunmaa, R Doyle, J Järnstedt, S Kamiza, J M Jorgensen, C P Stewart, L Shaw, L Hallamaa, U Ashorn, N Klein, K G Dewey, K Maleta, P Ashorn
OBJECTIVES: Maternal dental periapical infections are associated with preterm birth and intrauterine growth restriction. This study investigates whether the association is mediated through bacterial spread from periapical lesions to placenta (direct pathway) or systemic inflammatory reaction (indirect pathway). MATERIALS AND METHODS: We compared birth outcomes in Malawian mothers with and without periapical infection. As markers of a direct pathway, we identified placental bacteria using a 16S rDNA approach and assessed histological evidence of inflammation in the placenta and amniotic membranes...
December 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29207246/multiple-reaction-monitoring-for-the-quantitation-of-serum-protein-glycosylation-profiles-application-to-ovarian-cancer
#18
Suzanne Miyamoto, Carol D Stroble, Sandra Taylor, Qiuting Hong, Carlito B Lebrilla, Gary S Leiserowitz, Kyoungmi Kim, L Renee Ruhaak
Protein glycosylation fingerprints are widely recognized as potential markers for disease states, and indeed differential glycosylation has been identified in multiple types of autoimmune diseases and several types of cancer. However, releasing the glycans leave the glycoproteins unknown; therefore, there exists a need for high-throughput methods that allow quantification of site- and protein-specific glycosylation patterns from complex biological mixtures. In this study, a targeted multiple reaction monitoring (MRM)-based method for the protein- and site-specific quantitation involving serum proteins immunoglobulins A, G and M, alpha-1-antitrypsin, transferrin, alpha-2-macroglobulin, haptoglobin, alpha-1-acid glycoprotein and complement C3 was developed...
January 5, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29182756/acute-phase-proteins-and-stress-markers-in-the-immediate-response-to-a-combined-vaccination-against-newcastle-disease-and-infectious-bronchitis-viruses-in-specific-pathogen-free-spf-layer-chicks
#19
Haider Kaab, Maureen M Bain, Peter David Eckersall
Vaccination is an important tool in poultry health, but is itself a stressor often resulting in a reduction in feed intake, body weight gain, and nutrient digestibility. In other species, vaccination is associated with an immediate acute-phase response. As an important immune parameter, the circulating heterophil/lymphocyte (H/L) ratio is a well-recognized parameter of stress in poultry. In this study, the effects of a routinely used commercial poultry vaccine on the acute phase response (APR) and H/L ratios in specific pathogen-free (SPF) layer chicks was examined to determine if post vaccination (PV) stress and an APR occur...
February 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29158276/seventy-five-years-of-research-on-protein-binding
#20
REVIEW
Axel Dalhoff
This review summarizes evidence that the impact of protein binding of the activity of antibiotics is multifaceted and more complex than indicated by the numerical value of protein binding alone. A plethora of studies has proven that protein binding of antibiotics matters, as the free fraction only is antibacterially active and governs pharmacokinetics. Several studies have indicated that independent from protein binding of immunoglobulin G, albumin, α1 -acid-glycoprotein, and pulmonary surfactant acted synergistically with antibacterial agents, thus suggesting that some intrinsic properties of serum proteins may have mediated serum-antibiotic synergisms...
February 2018: Antimicrobial Agents and Chemotherapy
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