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Tetsuo Ashizawa
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April 2018: Lancet Neurology
Yang Wang, Xueping Kong, Wei Xu, Fengrui Jiang, Bao Li, Lixin Wu
A series of triol ligand [CH3 C(CH2 OH)3 ] covalently decorated polyoxometalates (POMs), which could be ascribed to the primary complexes with structural formulas {M2 [Mo2 O4 (CH3 C(CH2 O)3 )2 ]3 }2- (M = Cu2+ , Co2+ , Ni2+ , Zn2+ ), have been synthesized in organic solvents. Single-crystal X-ray structural analysis reveals that the synthesized polyanionic clusters are comprised of three {Mo2 } units and two divalent transition-metal ions connecting to each other in an alternating style, where all {Mo2 } blocks were covalently decorated by two triol ligands in the trans conformation...
March 19, 2018: Inorganic Chemistry
Meng-Ting Li, Xi-Ya Yang, Ji-Sen Li, Ning Sheng, Guo-Dong Liu, Jing-Quan Sha, Ya-Qian Lan
For exploring the multifold helical fabrication of polyoxometalate (POM)-based hybrid compounds, four POM-based crystalline compounds with different meso-helices, H3 [Ag27 (trz)16 (H2 O)6 ][SiW12 O40 ]2 ·5H2 O (1), H[Ag27 (trz)16 (H2 O)4 ][PW12 O40 ]2 ·2H2 O (2), [Ag23 (trz)14 (H2 O)2 ][HSiW12 O40 ] (3), and [Ag23 (trz)14 (H2 O)2 ][PW12 O40 ] (4), were successfully isolated by using the delicate 1,2,3-triazole ligand and silver ions in this work. Crystal analysis reveals that compounds 1 and 2 and compounds 3 and 4 are isomorphous and display 2-/4-fold mixed meso-helices and simple 2-fold meso-helices, respectively...
March 19, 2018: Inorganic Chemistry
Yangbo Wang, Bingxiao Yang, Kun Chen, Enlong Zhou, Qinghua Zhang, Lisha Yin, Xiaoji Xie, Lin Gu, Ling Huang
Scandium (Sc) sits at a unique position in the periodic table, i.e., the junction of the top of the rare earth column and the beginning of the transition metal row. Studies have shown that Sc-based nanomaterials are very sensitive to the surrounding chemical environment. A simple adjustment of the chemical reaction conditions such as temperature, surfactant molecules, and solvents (e.g., oleic acid (OA) or 1-octadecene (OD)) can easily lead to different products in terms of chemical composition and phase structure...
March 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Indresh Kumar Pandey, Mookan Natarajan, Hemlata Faujdar, Firasat Hussain, Matthias Stein, Sandeep Kaur-Ghumaan
The mono-substituted complex [Fe2(CO)5(μ-naphthalene-2-thiolate)2(P(PhOMe-p)3)] was prepared taking after the structural principles from both [NiFe] and [FeFe]-hydrogenase enzymes. Crystal structures are reported for this complex and the all carbonyl analogue. The bridging naphthalene thiolates resemble μ-bridging cysteine amino acids. One of the naphthyl moieties forms π-π stacking interactions with the terminal bulky phosphine ligand in the crystal structure and in calculations. This interaction stabilizes the reduced and protonated forms during electrocatalytic proton reduction in the presence of acetic acid and hinders the rotation of the phosphine ligand...
March 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Alexander E Kossak, Benjamin O Stephens, Yuan Tian, Pan Liu, Mingwei Chen, Thomas J Kempa
We propose and validate herein a solution-phase synthetic strategy relying on in situ photo-stimulation and reduction of metal-halide intermediates to yield complex anisotropic and multi-component nanostructures. Exposure of AgBr nanoparticles to ultraviolet light and L-Arginine forms dimers composed of crystalline Ag and AgBr nanophases. The Ag nanoparticle nucleates at and grows from a single point on the surface of the AgBr phase, and the interface connecting these phases is atomically sharp. The complex nanostructures are generated at greater than 80% yield and are highly monodisperse in morphology and in size...
March 19, 2018: Nano Letters
Xiao-Meng Zhang, Yong-Nan Jin, Bing Zhang, Ning Li
Rheumatoid arthritis (RA) has the characteristics of long course of disease and difficulty in treatment. The conventional therapy may easily induce adverse drug reactions or events (ADR/ADE) due to the long-time medication. Thus, it should be given special attentions to treatment benefit and medication risk of RA patients. Aconitum, a kind of toxic traditional Chinese herbs, is an important complement therapy for RA, with some controversy in clinical application. Coming straight to the practical problem of combined use of traditional Chinese medicines (TCM) and Western medicines (WM), this study conducted quantitative assessment on the benefits and risks of Aconitum using combined with WM or not, which was carried out by the method of multi-criteria decision analysis model...
January 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Marta Sánchez-Soto, Verònica Casadó-Anguera, Hideaki Yano, Brian Joseph Bender, Ning-Sheng Cai, Estefanía Moreno, Enric I Canela, Antoni Cortés, Jens Meiler, Vicent Casadó, Sergi Ferré
The poor norepinephrine innervation and high density of Gi/o-coupled α2A - and α2C -adrenoceptors in the striatum and the dense striatal dopamine innervation have prompted the possibility that dopamine could be an effective adrenoceptor ligand. Nevertheless, the reported adrenoceptor agonistic properties of dopamine are still inconclusive. In this study, we analyzed the binding of norepinephrine, dopamine, and several compounds reported as selective dopamine D2 -like receptor ligands, such as the D3 receptor agonist 7-OH-PIPAT and the D4 receptor agonist RO-105824, to α2 -adrenoceptors in cortical and striatal tissue, which express α2A -adrenoceptors and both α2A - and α2C -adrenoceptors, respectively...
March 18, 2018: Molecular Neurobiology
Arup Tarai, Jubaraj B Baruah
A series of mononuclear complexes of divalent nickel and zinc with N-(4-methoxyphenyl)-2-(propan-2-ylidene)hydrazine carbothioamide (H2Lmethoxy) as well as with N-(4-nitrophenyl)-2-(propan-2-ylidene)hydrazine carbothioamide (H2Lnitro) have been structurally characterised. Among these two ligands, H2Lnitro formed an analogous copper(ii) complex to that of nickel and zinc, whereas H2Lmethoxy undergoes a catalytic cyclisation reaction in the presence of copper(ii) nitrate trihydrate. Control experiments based on ESR have revealed that copper(ii) is reduced to copper(i) and reverts back to copper(ii) as the cyclisation reaction proceeds, generating a catalytic reaction...
March 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Anna Cressey, Deborah S Jacobs, Crystal Remington, Karen G Carrasquillo
Purpose: To demonstrate clearing of chronic corneal opacities and improvement of visual acuity with the use of BostonSight prosthetic replacement of the ocular surface ecosystem (PROSE) treatment in ocular surface disease. Observations: We undertook retrospective analysis of the medical records of a series of patients who underwent PROSE treatment from August 2006 to December 2014. Patients were referred for ocular surface disease of various etiologies. Primary inclusion criterion was corneal opacity that improved with PROSE treatment...
June 2018: American Journal of Ophthalmology Case Reports
Kamila Kočí, Ivana Troppová, Martin Reli, Lenka Matějová, Miroslava Edelmannová, Helena Drobná, Lada Dubnová, Anna Rokicińska, Piotr Kuśtrowski, Libor Čapek
Neodymium enriched TiO2 anatase-brookite powders were prepared by unconventional method via using pressurized hot fluids for TiO2 crystallization and purification. The photocatalysts were tested in the CH3 OH photocatalytic decomposition and they were characterized with respect to the textural (nitrogen adsorption), structural (XRD, XPS, and Raman spectroscopies), chemical (XRF), and optical (DR UV-Vis spectroscopy) and photoelectrochemical measurement. All prepared materials were nanocrystalline, had biphasic (anatase- brookite) structure and relatively large specific surface area (125 m2 ...
2018: Frontiers in Chemistry
Peifeng Jing, Yannan Liu, Ethan G Keeler, Nelly M Cruz, Benjamin S Freedman, Lih Y Lin
Cell manipulation is one of the most impactful applications for optical tweezers, and derived from this promise, we demonstrate a new optical tweezers system for the study of cell adhesion and organization. This method utilizes photonic-crystal-enhanced optical tweezers to manipulate cells with low laser intensities. By doing so, it enables effective cell patterning and culturing within the conditions necessary for successful differentiation and colony formation of human pluripotent stem cells. To this end, the biocompatibility of plasma-treated parylene-C for cell culturing was studied, and a thorough characterization of cellular interactive forces was performed using this system...
February 1, 2018: Biomedical Optics Express
Riccardo Rizzo, Maria Alvaro, Norbert Danz, Lucia Napione, Emiliano Descrovi, Stefan Schmieder, Alberto Sinibaldi, Subinoy Rana, Rona Chandrawati, Peter Munzert, Thomas Schubert, Emmanuel Maillart, Aleksei Anopchenko, Paola Rivolo, Alessandro Mascioletti, Erik Förster, Frank Sonntag, Molly M Stevens, Federico Bussolino, Francesco Michelotti
Quantitative detection of angiogenic biomarkers provides a powerful tool to diagnose cancers in early stages and to follow its progression during therapy. Conventional tests require trained personnel, dedicated laboratory equipment and are generally time-consuming. Herein, we propose our developed biosensing platform as a useful tool for a rapid determination of Angiopoietin-2 biomarker directly from patient plasma within 30 minutes, without any sample preparation or dilution. Bloch surface waves supported by one dimensional photonic crystal are exploited to enhance and redirect the fluorescence arising from a sandwich immunoassay that involves Angiopoietin-2...
February 1, 2018: Biomedical Optics Express
Siyuan Luo, Maxime A Siegler, Elisabeth Bouwman
Four dimeric nickel(II) complexes [Ni2 Cl2 (BnC2 S)2 ] [ 1 ], [Ni2 Cl2 (BnC3 S)2 ] [ 2 ], [Ni2 (PyC2 S)2 ]Br2 [ 3 ]Br2 , and [Ni2 (PyC3 S)2 ]Br2 [ 4 ]Br2 of four different thiolate-functionalized N-heterocyclic carbene (NHC) ligands were synthesized, and their structures have been determined by single-crystal X-ray crystallography. The four ligands differ by the alkyl chain length between the thiolate group and the benzimidazole nitrogen (two -C2 - or three -C3 - carbon atoms) and the second functionality at the NHC being a benzyl (Bn) or a pyridylmethyl (Py) group...
March 12, 2018: Organometallics
Jennifer Chia Wee Fern, Shuji Ohsaki, Satoru Watano, Robert Pfeffer
The synthesis of nano-size drug particles by antisolvent crystallization using a porous hollow fiber membrane provides promising benefits such as the capability of continuous operation, low energy input, and ease of scale-up for a variety of industrial processes. Porous hollow fiber membranes have also been shown to produce more efficient mixing than conventional mixing equipment mostly because in mixing binary fluids, they provide sufficient mixing time, retention time, and a large contact interface for the drug solution and the antisolvent, allowing for the precise control of nucleation and crystal growth necessary to form nano-size particles...
March 15, 2018: International Journal of Pharmaceutics
Varda Shoshan-Barmatz, Edna Nahon-Crystal, Anna Shteinfer-Kuzmine, Rajeev Gupta
Alzheimer's disease (AD) is an age-related neurodegenerative disorder. Although an accumulation of brain amyloid-β (Aβ) peptide and hyperphosphorylated tau protein have been implicated in the pathogenesis of AD, the etiology of the disease remains unclear. Mitochondrial dysfunction has been identified as an early event in AD pathogenesis and is reflected by reduced metabolism, disruption of Ca2+ homeostasis, and increased levels of reactive oxygen species, lipid peroxidation, and apoptosis. The focus of this review is the involvement of mitochondrial dysfunction in AD, and specifically, the role of the voltage-dependent anion channel 1 (VDAC1), which has been linked to AD pathogenesis...
March 15, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Travis R Helgren, Elif S Seven, Congling Chen, Thomas E Edwards, Bart L Staker, Jan Abendroth, Peter J Myler, James R Horn, Timothy J Hagen
Methionine aminopeptidase (MetAP) is a dinuclear metalloprotease responsible for the cleavage of methionine initiator residues from nascent proteins. MetAP activity is necessary for bacterial proliferation and is therefore a projected novel antibacterial target. A compound library consisting of 294 members containing metal-binding functional groups was screened against Rickettsia prowazekii MetAP to determine potential inhibitory motifs. The compounds were first screened against the target at a concentration of 10 µM and potential hits were determined to be those exhibiting greater than 50% inhibition of enzymatic activity...
March 15, 2018: Bioorganic & Medicinal Chemistry Letters
Sung-Hoon Kim, Chan-Jin Park, Lee-Ra Cho, Yoon-Hyuk Huh
STATEMENT OF PROBLEM: Little information is available for the strength of bonding between zirconia and lithium disilicate as affected by surface pretreatment methods. PURPOSE: The purpose of this in vitro study was to investigate the shear bond strength (SBS) between zirconia core and lithium disilicate (LS2 ) veneered ceramic after surface pretreatments. MATERIAL AND METHODS: Fully sintered yttrium oxide partially stabilized tetragonal zirconia (Y-TZP) disk specimens were fabricated from zirconia ceramic materials...
March 15, 2018: Journal of Prosthetic Dentistry
Ting Zhang, Liping Wang, Ying Bao, Qi Yang, Lina Zhou, Hongxun Hao, Chuang Xie
Polymorphic forms of etoricoxib have been reported in the literature and form I was considered to be the most stable one. However, in this work, it was found that form I and form V are enantiotropic by DSC analysis, solubility measurements and solution-mediated polymorphic transformation experiments with form V being more stable than form I at room temperature. Thermodynamic transition temperature is determined as (353.45 ± 0.10) K. Besides, form V would transform to form I with the seeding effect of form I at high temperature below the melting point of form V...
March 15, 2018: Journal of Pharmaceutical Sciences
Hongyi Xu, Hugo Lebrette, Taimin Yang, Vivek Srinivas, Sven Hovmöller, Martin Högbom, Xiaodong Zou
Recent developments of novel electron diffraction techniques have shown to be powerful for determination of atomic resolution structures from micron- and nano-sized crystals, too small to be studied by single-crystal X-ray diffraction. In this work, the structure of a rare lysozyme polymorph is solved and refined using continuous rotation MicroED data and standard X-ray crystallographic software. Data collection was performed on a standard 200 kV transmission electron microscope (TEM) using a highly sensitive detector with a short readout time...
March 1, 2018: Structure
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