keyword
MENU ▼
Read by QxMD icon Read
search

crystals

keyword
https://www.readbyqxmd.com/read/29352744/crystal-structure-of-adp-dependent-glucokinase-from-methanocaldococcus-jannaschii-in-complex-with-5-iodotubercidin-reveals-phosphoryl-transfer-mechanism
#1
Piotr Tokarz, Magdalena Wiśniewska, Marcin M Kamiński, Grzegorz Dubin, Przemysław Grudnik
ADP-dependent glucokinase (ADPGK) is an alternative novel glucose phosphorylating enzyme in a modified glycolysis pathway of hyperthermophilic Archaea. In contrast to classical ATP-dependent hexokinases, ADPGK utilizes ADP as a phosphoryl group donor. Here we present a crystal structure of archaeal ADPGK from Methanocaldococcus jannaschii in complex with an inhibitor, 5-iodotubercidin, D-glucose, inorganic phosphate and a magnesium ion. Detailed analysis of the architecture of the active site allowed for confirmation of the previously proposed phosphorylation mechanism and the crucial role of the invariant arginine residue (Arg197)...
January 20, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29352739/determination-of-protein-oligomeric-structure-from-small-angle-x-ray-scattering
#2
REVIEW
David A Korasick, John J Tanner
Small-angle X-ray scattering (SAXS) is useful for determining the oligomeric states and quaternary structures of proteins in solution. The average molecular mass in solution can be calculated directly from a single SAXS curve collected on an arbitrary scale from a sample of unknown protein concentration, without the need for beamline calibration or protein standards. The quaternary structure in solution can be deduced by comparing the experimental SAXS curve to theoretical curves calculated from proposed models of the oligomer...
January 20, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29352570/the-nlrp3-inflammasome-and-the-emerging-role-of-colchicine-to-inhibit-atherosclerosis-associated-inflammation
#3
REVIEW
Gonzalo J Martínez, David S Celermajer, Sanjay Patel
Atherosclerosis is considered a chronic inflammatory disease of the arterial wall. Recently, compelling evidence has arisen for the role of monocytes and neutrophils and a particular protein complex that resides within these cells - the NLRP3 inflammasome - in atherosclerosis-associated inflammation. It is now also known that cholesterol crystals are present through all stages of atherosclerosis and can activate the NLRP3 inflammasome within these inflammatory cells to produce interleukin 1β and interleukin 18 - key mediators in the inflammatory cascade that drive plaque progression and instability...
December 25, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29352367/continuous-manufacturing-of-co-crystals-challenges-and-prospects
#4
REVIEW
Rahul B Chavan, Rajesh Thipparaboina, Balvant Yadav, Nalini R Shastri
The last decade has witnessed extensive growth in the field of co-crystallization for mitigating the solubility and dissolution-related issues of poorly soluble drugs. This is largely because co-crystals can modify the physicochemical properties of drugs without any covalent modification in the drug molecules. The US Food and Drug Administration (FDA) now considers drug products that are designed to contain a new co-crystal, analogous to new polymorph of the active pharmaceutical ingredient (API). This positive change in regulatory perspective coupled with successful commercialization of valsartan-sacubitril co-crystal (Entresto, Novartis) has now brought co-crystals into focus, in both industries as well as academia...
January 19, 2018: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/29352301/crystal-structure-of-a-udp-glcnac-epimerase-for-surface-polysaccharide-biosynthesis-in-acinetobacter-baumannii
#5
Bhumika S Shah, Heather E Ashwood, Stephen J Harrop, Daniel N Farrugia, Ian T Paulsen, Bridget C Mabbutt
With new strains of Acinetobacter baumannii undergoing genomic analysis, it has been possible to define regions of genomic plasticity (RGPs), encoding specific adaptive elements. For a selected RGP from a community-derived isolate of A. baumannii, we outline sequences compatible with biosynthetic machinery of surface polysaccharides, specifically enzymes utilized in the dehydration and conversion of UDP-N-acetyl-D-glucosamine (UDP-D-GlcNAc). We have determined the crystal structure of one of these, the epimerase Ab-WbjB...
2018: PloS One
https://www.readbyqxmd.com/read/29352206/omega-3-carboxylic-acids-provide-efficacious-anti-inflammatory-activity-in-models-of-crystal-mediated-inflammation
#6
Cory Iverson, Andrew Bacong, Sha Liu, Scott Baumgartner, Torbjörn Lundström, Jan Oscarsson, Jeffrey N Miner
This study assesses the efficacy and exposure-response relationship of omega-3-carboxylic acids (OM-3 CA) in models of crystal-based inflammation. Human THP-1 macrophages and primary peripheral blood mononuclear cells exposed to multiple inflammatory crystal types were used to determine the anti-inflammatory potential of omega-3 (OM-3) fatty acids in vitro. Anti-inflammatory effects of OM-3 CA in vivo were tested in rat monosodium urate (MSU) crystal air pouch and rat knee intra-articular MSU injection models...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352204/local-structure-nucleation-sites-and-crystallization-behavior-and-their-effects-on-magnetic-properties-of-fe81si-x-b10p8-xcu1-x%C3%A2-%C3%A2-0-8
#7
C C Cao, Y G Wang, L Zhu, Y Meng, X B Zhai, Y D Dai, J K Chen, F M Pan
In this work, an attempt has been made to reveal critical factors dominating the crystallization and soft magnetic properties of Fe81Si x B10P8-xCu1 (x = 0, 2, 4, 6 and 8) alloys. Both melt spun and annealed alloys are characterized by differential scanning calorimetry, X-ray diffractometry, Mössbauer spectroscopy, transmission electron microscopy, positron annihilation lifetime spectroscopy and magnetometry. The changes in magnetic interaction between Fe atoms and chemical homogeneity can well explain the variation of magnetic properties of Fe81Si x B10P8-xCu1 amorphous alloys...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352148/stochastic-optimization-of-broadband-reflecting-photonic-structures
#8
D Estrada-Wiese, E A Del Río-Chanona, J A Del Río
Photonic crystals (PCs) are built to control the propagation of light within their structure. These can be used for an assortment of applications where custom designed devices are of interest. Among them, one-dimensional PCs can be produced to achieve the reflection of specific and broad wavelength ranges. However, their design and fabrication are challenging due to the diversity of periodic arrangement and layer configuration that each different PC needs. In this study, we present a framework to design high reflecting PCs for any desired wavelength range...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352144/pressure-assisted-enhancement-in-superconducting-properties-of-fe-substituted-nbse2-single-crystal
#9
Manikandan Krishnan, Rukshana Pervin, Kalai Selvan Ganesan, Kannan Murugesan, Govindaraj Lingannan, Akshay Kumar Verma, Parasharam M Shirage, Arumugam Sonachalam
The impact of hydrostatic pressure (P) up to 1 GPa on T c , J c and the nature of the pinning mechanism in FexNbSe2 single crystals have been investigated within the framework of the collective theory. We found that the pressure can induce a transition from the regime where pinning is controlled by spatial variation in the critical transition temperature (δT c ) to the regime controlled by spatial variation in the mean free path (δℓ). Furthermore, T c and low field J c are slightly induced, although the J c drops more rapidly at high fields than at ambient P...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352141/pressure-effect-on-impurity-local-vibrational-mode-and-phase-transitions-in-n-type-iron-doped-indium-phosphide
#10
Chih-Ming Lin, I-Jui Hsu, Sin-Cheng Lin, Yu-Chun Chuang, Wei-Ting Chen, Yen-Fa Liao, Jenh-Yih Juang
The evolution of iron local vibrational mode (Fe LVM) and phase transitions in n-type iron-doped indium phosphide (InP:Fe) were investigated at ambient temperature. In-situ angle-dispersive X-ray diffraction measurements revealed that InP:Fe starts to transform from zinc-blende (ZB) to rock-salt (RS) structure around 8.2(2) GPa and completes around 16.0(2) GPa. The Raman shift of both transverse and longitudinal optical modes increases monotonically with increasing pressure, while their intensities become indiscernible at 11...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352125/biomolecular-regulation-composition-and-nanoarchitecture-of-bone-mineral
#11
Atharva A Poundarik, Adele Boskey, Caren Gundberg, Deepak Vashishth
Tough natural nanocomposites like bone, nacre and sea sponges contain within their hierarchy, a mineral (phosphate, silicate or carbonate) phase that interacts with an organic phase. In bone, the role of mineral ultrastructure (organization, morphology, composition) is crucial to the mechanical and biological properties of the tissue. Better understanding of mineral interaction with the organic matrix, in particular non-collagenous proteins, osteocalcin (OC) and osteopontin (OPN), can lead to better design of biomimetic materials...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352107/mycolyltransferase-from-mycobacterium-tuberculosis-in-covalent-complex-with-tetrahydrolipstatin-provides-insights-into-antigen-85-catalysis
#12
Christopher M Goins, Steven Dajnowicz, Micholas D Smith, Jerry M Parks, Donald R Ronning
Mycobacterium tuberculosis Antigen 85 enzymes (Ag85s) catalyze the transfer of mycolic acid (MA) from trehalose monomycolate to produce the mycolyl arabinogalactan (mAG) or trehalose dimycolate (TDM). These lipids define the protective mycomembrane of Mycobacteria. The current model of substrate binding within the active sites of Ag85s for the production of TDM is not sterically and geometrically feasible; additionally, this model does not account for the production of mAG. Furthermore, this model does not address how Ag85s limit the hydrolysis of the acyl-enzyme intermediate while catalyzing acyl transfer...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29352106/cholesterol-binding-to-a-conserved-site-modulates-conformation-pharmacology-and-transport-kinetics-of-the-human-serotonin-transporter
#13
Louise Laursen, Kasper Severinsen, Kristina Birch Kristensen, Xavier Periole, Malene Overby, Heidi Kaastrup Müller, Birgit Schiøtt, Steffen Sinning
The serotonin transporter (SERT) is important for reuptake of the neurotransmitter serotonin from the synaptic cleft and is also the target of most antidepressants. It has previously been shown that cholesterol in the membrane bilayer affects the conformation of the serotonin transporter. Although recent crystal structures have identified several potential cholesterol binding sites it is unclear whether any of these potential cholesterol sites are occupieed by cholesterol and functionally relevant. In the present study we focus on the conserved Cholesterol Site 1 (CHOL1) located in a hydrophobic groove between TM1a, TM5 and TM7...
January 19, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29351949/pt-and-ot-helper-golf-elbow-a-mobile-app-user-guide-for-getting-a-grip-on-medial-epicondylalgia
#14
Caitlin George, Crystal O Kean, Robert Stanton, Luke J Heales
No abstract text is available yet for this article.
January 19, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29351793/retinal-complications-of-gout-a-case-report-and-review-of-the-literature
#15
Ying Jiang, Jason E Brenner, William J Foster
BACKGROUND: There have been few reported findings of posterior segment complications of gout. While exudative lesions, an increased risk of macular degeneration, and vascular occlusions have been previously reported, to our knowledge, refractile macular lesions have not been reported in a patient with chronic uncontrolled gout. CASE PRESENTATION: Highly refractile, crystal-like lesions were found in the macula of a 62 year old male patient with chronically uncontrolled gout...
January 19, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29351792/successful-recruitment-to-trials-findings-from-the-scimitar-trial
#16
Emily Peckham, Catherine Arundel, Della Bailey, Tracy Callen, Christina Cusack, Suzanne Crosland, Penny Foster, Hannah Herlihy, James Hope, Suzy Ker, Tayla McCloud, Crystal-Bella Romain-Hooper, Alison Stribling, Peter Phiri, Ellen Tait, Simon Gilbody
BACKGROUND: Randomised controlled trials (RCT) can struggle to recruit to target on time. This is especially the case with hard to reach populations such as those with severe mental ill health. The SCIMITAR+ trial, a trial of a bespoke smoking cessation intervention for people with severe mental ill health achieved their recruitment ahead of time and target. This article reports strategies that helped us to achieve this with the aim of aiding others recruiting from similar populations...
January 19, 2018: Trials
https://www.readbyqxmd.com/read/29351750/associations-of-land-cattle-and-food-security-with-infant-feeding-practices-among-a-rural-population-living-in-manyara-tanzania
#17
Bailey Hanselman, Ramya Ambikapathi, Estomih Mduma, Erling Svensen, Laura E Caulfield, Crystal L Patil
BACKGROUND: Livelihoods strategies and food security experiences can positively and negatively affect infant and young child feeding (IYCF) practices. This study contributes to this literature by exploring how variation in household economics among rural farmers in Tanzania relates to IYCF patterns over the first 8 months of an infant's life. METHODS: These data were produced from a longitudinal study in which a cohort of mother-infant dyads was followed from birth to 24 months...
January 19, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29351451/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction
#18
Merry L Lindsey, Roberto Bolli, John M Canty, Xiao-Jun Du, Nikolaos G Frangogiannis, Stefan Frantz, Robert G Gourdie, Jeffrey W Holmes, Steven P Jones, Robert Kloner, David J Lefer, Ronglih Liao, Elizabeth Murphy, Peipei Ping, Karin Przyklenk, Fabio A Recchia, Lisa Schwartz Longacre, Crystal May Ripplinger, Jennifer E Van Eyk, Gerd Heusch
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction...
January 12, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351374/fast-dynamic-docking-guided-by-adaptive-electrostatic-bias-the-md-binding-approach
#19
Andrea Spitaleri, Sergio Decherchi, Andrea Cavalli, Walter Rocchia
Engineering chemical entities to modify how pharmaceutical targets function, as it is done in drug design, requires a good understanding of molecular recognition and binding. In this context, the limitations of statically describing bimolecular recognition, as done in docking/scoring, call for insightful and efficient dynamical investigations. On the experimental side, the characterization of dynamical binding processes is still in its infancy. Thus, computer simulations, particularly molecular dynamics (MD), are compelled to play a prominent role, allowing a deeper comprehension of the binding process and its causes and thus a more informed compound selection, making more significant the computational contribution to drug discovery1...
January 19, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29351373/a-facile-space-confined-solid-phase-sulfurization-strategy-for-growth-of-high-quality-ultrathin-molybdenum-disulfide-single-crystals
#20
Dawei Li, Zhiyong Xiao, Sai Mu, Fei Wang, Ying Liu, Jingfeng Song, Xi Huang, Lijia Jiang, Jun Xiao, Lei Liu, Stephen Ducharme, Bai Cui, Xia Hong, Lan Jiang, Jean-Francois Silvain, Yongfeng Lu
Single-crystal transition metal dichalcogenides (TMDs) and TMD-based hetero-junctions have recently attracted significant research and industrial interest owing to their intriguing optical and electrical properties. However, the lack of a simple, low-cost, environmentally friendly, synthetic method and a poor understanding of the growth mechanism post a huge challenge to implementing TMDs in practical applications. In this work, we developed a novel approach for direct formation of high-quality, monolayer and few-layer MoS2 single crystal domains via a single-step rapid thermal processing of a sandwiched reactor with sulfur and molybdenum (Mo) film in a confined reaction space...
January 19, 2018: Nano Letters
keyword
keyword
34160
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"