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Xuan Zhou, Wei Zhu, Margaret Nowicki, Shida Miao, Haitao Cui, Benjamin Holmes, Robert I Glazer, Lijie Grace Zhang
Metastasis is one of the deadliest consequences of breast cancer, with bone being one of the primary sites of occurrence. Insufficient 3D biomimetic models currently exist to replicate this process in vitro. In this study, we developed a biomimetic bone matrix using 3D bioprinting technology to investigate the interaction between breast cancer (BrCa) cells and bone stromal cells (fetal osteoblasts and human bone marrow mesenchymal stem cells (MSCs)). A tabletop stereolithography 3D bioprinter was employed to fabricate a series of bone matrices consisting of osteoblasts/MSCs encapsulated in gelatin methacrylate (GelMA) hydrogel with nanocrystalline hydroxyapatite (nHA)...
October 21, 2016: ACS Applied Materials & Interfaces
Abdulaziz AlHelal, Hamad S AlRumaih, Mathew T Kattadiyil, Nadim Z Baba, Charles J Goodacre
STATEMENT OF PROBLEM: Clinical studies comparing the retention values of milled denture bases with those of conventionally processed denture bases are lacking. PURPOSE: The purpose of this clinical study was to compare the retention values of conventional heat-polymerized denture bases with those of digitally milled maxillary denture bases. MATERIAL AND METHODS: Twenty individuals with completely edentulous maxillary arches participated in this study...
October 17, 2016: Journal of Prosthetic Dentistry
H Chen, T Zhao, Y Wang, Y C Sun
OBJECTIVE: To establish a digital method for production of custom trays for edentulous jaws using fused deposition modeling (FDM) based on three-dimensional (3D) scans of primary jaw impressions, and to quantitatively evaluate the accuracy. METHODS: A red modeling compound was used to make a primary impression of a standard maxillary edentulous plaster model. The plaster model data and the primary impression tissue surface data were obtained using a 3D scanner. In the Gemomagic 2012 software, several commands were used, such as interactive drawing curves, partial filling holes, local offset, bodily offset, bodily shell, to imitate clinical procedures of drawing tray boundary, filling undercut, buffer, and generating the tray body...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Bas van Bochove, Gerjon Hannink, Pieter Buma, Dirk W Grijpma
Three-armed poly(trimethylene carbonate) macromers with a relatively high molecular weight of 28.9 kg mol(-1) are prepared by ring opening polymerization and subsequent functionalization with methacrylate end groups. A resin suitable for processing by stereolithography is developed using propylene carbonate as a diluent, a photoinitiator, and a dye to control the curing characteristics. The difficulties in building designed structures with digital light processing stereolithography and the ways of optimizing the resin compositions are described in detail...
October 17, 2016: Macromolecular Bioscience
D Olvera-Trejo, L F Velásquez-García
This study reports the first MEMS multiplexed coaxial electrospray sources in the literature. Coaxial electrospraying is a microencapsulation technology based on electrohydrodynamic jetting of two immiscible liquids, which allows precise control with low size variation of the geometry of the core-shell particles it generates, which is of great importance in numerous biomedical and engineering applications, e.g., drug delivery and self-healing composites. By implementing monolithic planar arrays of miniaturized coaxial electrospray emitters that work uniformly in parallel, the throughput of the compound microdroplet source is greatly increased, making the microencapsulation technology compatible with low-cost commercial applications...
October 18, 2016: Lab on a Chip
A Ronca, S Ronca, G Forte, S Zeppetelli, A Gloria, R De Santis, L Ambrosio
A vinyl-terminated Polycaprolactone has been developed for tissue engineering applications using a one-step synthesis and functionalization method based on Ring Opening Polymerization (ROP) of ԑ-caprolactone, with Hydroxyl Ethyl Vinyl Ether (HEVE) acting both as the initiator of ROP and as photo-curable functional group. The proposed method employs a catalyst based on Al, instead of the most popular Tin(II) 2-ethylhexanoate, to reduce the cytotoxicity. Following the synthesis of the vinyl-terminated polycaprolactone, its reaction with Fumaryl Chloride (FuCl) results in a divinyl-fumarate polycaprolactone (VPCLF)...
September 30, 2016: Journal of Tissue Engineering and Regenerative Medicine
Joshua L Hermsen, Thomas M Burke, Stephen P Seslar, David S Owens, Beth A Ripley, Nahush A Mokadam, Edward D Verrier
OBJECTIVE: Static 3-dimensional printing is used for operative planning in cases that involve difficult anatomy. An interactive 3D print allowing deliberate surgical practice would represent an advance. METHODS: Two patients with hypertrophic cardiomyopathy had 3-dimensional prints constructed preoperatively. Stereolithography files were generated by segmentation of chest computed tomographic scans. Prints were made with hydrogel material, yielding tissue-like models that can be surgically manipulated...
August 20, 2016: Journal of Thoracic and Cardiovascular Surgery
Dong-Yeon Kim, Jin-Hun Jeon, Ji-Hwan Kim, Hae-Young Kim, Woong-Chul Kim
STATEMENT OF PROBLEM: Microstereolithography (μ-SLA), a form of additive manufacturing, can produce one or more platforms of resin copings. However, no evaluation has been made of the variation in marginal discrepancy using this method, even though this is an important factor for a successful restoration. PURPOSE: The purpose of this in vitro study was to evaluate the reproducibility and marginal discrepancy of resin copings fabricated using dental μ-SLA. MATERIAL AND METHODS: A master die of a mandibular right first molar tooth was made from Type IV stone and scanned to produce a stereolithography file...
September 16, 2016: Journal of Prosthetic Dentistry
Nawal Alharbi, Reham B Osman, Daniel Wismeijer
PURPOSE: The aim of the present study was to evaluate the effect of the build angle and the support configuration (thick versus thin support) on the dimensional accuracy of 3D-printed full-coverage dental restorations. MATERIALS AND METHODS: A full-coverage dental crown was digitally designed and 3D-printed using stereolithography-additive manufacturing (SLA-AM) technology. Nine different angles were used during the build process: 90, 120, 135, 150, 180, 210, 225, 240, and 270 degrees...
September 2016: International Journal of Prosthodontics
Caterina Credi, Alessandro Fiorese, Marco Tironi, Roberto Bernasconi, Luca Magagnin, Marinella Levi, Stefano Turri
In the present work, prototypes of polymeric cantilever-based magnetic microstructures were fabricated by means of stereolithography (SL). To this end, a UV-curable system suitable for high-resolution SL-processing was formulated by blending a bifunctional acrylic monomer with photoinitiator and visible dye whose content was tuned to tailor resin SL sensitivity. Subsequently, to confer ferromagnetic properties to the photopolymer, two different strategies were implemented. A two-step approach involved selective deposition of a metal layer on photopolymer SL-cured surfaces through an electroless plating process...
October 5, 2016: ACS Applied Materials & Interfaces
Xuan Zhou, Nathan J Castro, Wei Zhu, Haitao Cui, Mitra Aliabouzar, Kausik Sarkar, Lijie Grace Zhang
3D printing and ultrasound techniques are showing great promise in the evolution of human musculoskeletal tissue repair and regeneration medicine. The uniqueness of the present study was to combine low intensity pulsed ultrasound (LIPUS) and advanced 3D printing techniques to synergistically improve growth and osteogenic differentiation of human mesenchymal stem cells (MSC). Specifically, polyethylene glycol diacrylate bioinks containing cell adhesive Arginine-Glycine-Aspartic acid-Serene (RGDS) peptide and/or nanocrystalline hydroxyapatite (nHA) were used to fabricate 3D scaffolds with different geometric patterns via novel table-top stereolithography 3D printer...
2016: Scientific Reports
Frédéric Dumur, Didier Gigmes, Jean-Pierre Fouassier, Jacques Lalevée
Photoinitiated polymerization has been the subject of continued research efforts due to the numerous applications in which this polymerization technique is involved (coatings, inks, adhesives, optoelectronic, laser imaging, stereolithography, nanotechnology, etc.). More recently, photopolymerization has received renewed interest due to the emergence of 3D-printing technologies. However, despite current academic and industrial interest in photopolymerization methodologies, a major limitation lies in the slow rates of photopolymerization...
September 20, 2016: Accounts of Chemical Research
Gayatri Shankaran, Suryakant Chhagan Deogade, Rajesh Dhirawani
Rapid prototyping (RP) is a technique of manufacturing parts by the additive layer manufacturing technology; where, a three-dimensional (3D) model created in a computer aided design (CAD) system is sectioned into 2D profiles, which are further constructed by RP layer by layer. Its use is not limited to industrial or engineering fields and has extended to the medical field for the manufacturing of custom implants and prostheses, the study of anatomy and surgical planning. Nowadays, dentists are more frequently encountered with the individuals affected with craniofacial defects due to trauma...
January 2016: Journal of Dentistry of Tehran University of Medical Sciences
Ruichen Wang, Guizhen Li, Chunming Liu, Chiyu Jia, Yan Han
BACKGROUND: Contouring is a minimal invasive procedure to remove excess lesions and restore facial appearance of patients with craniofacial fibrous dysplasia; however, it is difficult to measure the amount of excess lesions. This study is to demonstrate the use of reduction template produced by three-dimensional printer in contouring procedure. METHODS: Computed tomography data were reconstructed into a three-dimensional model by Mimics software. The unaffected side was mirrored and superimposed on the affected side...
October 2016: Journal of Craniofacial Surgery
Pascal Magne, Raymond Cheung
STATEMENT OF PROBLEM: Selecting material for a minimally invasive occlusal veneer reconstruction concept requires an understanding of how stresses are distributed during functional and parafunctional forces. PURPOSE: The purpose of this in vitro study was to investigate stress distribution in a maxillary molar restored with ultrathin occlusal veneers and subjected by an antagonistic mandibular molar to clenching and working and nonworking movements. MATERIAL AND METHODS: A maxillary first molar was modeled from microcomputed tomography (micro-CT) data, using medical image processing software, stereolithography editing/optimizing software, and finite element software...
August 7, 2016: Journal of Prosthetic Dentistry
Takehiko Konno, Toshihiro Mashiko, Hirofumi Oguma, Naoki Kaneko, Keisuke Otani, Eiju Watanabe
We developed a method for manufacturing solid models of cerebral aneurysms, with a shorter printing time than that involved in conventional methods, using a compact 3D printer with acrylonitrile-butadiene-styrene(ABS)resin. We further investigated the application and utility of this printing system in emergency clipping surgery. A total of 16 patients diagnosed with acute subarachnoid hemorrhage resulting from cerebral aneurysm rupture were enrolled in the present study. Emergency clipping was performed on the day of hospitalization...
August 2016: No Shinkei Geka. Neurological Surgery
Hasan Anıl Atalay, Volkan Ülker, İlter Alkan, Halil Lütfi Canat, Ünsal Özkuvancı, Fatih Altunrende
OBJECTIVE: To investigate the impact of three-dimensional (3D) printed pelvicaliceal system models on residents' understanding of pelvicaliceal system anatomy before percutaneous nephrolithotripsy (PCNL). MATERIALS AND METHODS: Patients with unilateral complex renal stones indicating PCNL were selected. Usable data of patients were obtained from CT-scans in Digital Imaging and Communications in Medicine (DICOM) format. Mimics software version 16.0 (Materialise, Belgium) was used for segmentation and extraction of pelvicaliceal systems (PCSs)...
October 2016: Journal of Endourology
Jonathan I Gear, Craig Cummings, Allison J Craig, Antigoni Divoli, Clive D C Long, Michael Tapner, Glenn D Flux
BACKGROUND: The use of selective internal radiation therapy (SIRT) is rapidly increasing, and the need for quantification and dosimetry is becoming more widespread to facilitate treatment planning and verification. The aim of this project was to develop an anthropomorphic phantom that can be used as a validation tool for post-SIRT imaging and its application to dosimetry. METHOD: The phantom design was based on anatomical data obtained from a T1-weighted volume-interpolated breath-hold examination (VIBE) on a Siemens Aera 1...
December 2016: EJNMMI Physics
Giovanni Anthony, Ju-Ahng Lee
Recent development in 3D printing technology has opened an exciting possibility for manufacturing 3D devices on one's desktop. We used 3D modeling programs to design 3D models of a tissue-handling system and these models were "printed" in a stereolithography (SLA) 3D printer to create precision histology devices that are particularly useful to handle multiple samples with small dimensions in parallel. Our system has been successfully tested for in situ hybridization of zebrafish embryos. Some of the notable features include: (1) A conveniently transferrable chamber with 6 mesh-bottomed wells, each of which can hold dozens of zebrafish embryos...
2016: PloS One
David S C Soon, Michael P Chae, Charles H C Pilgrim, Warren Matthew Rozen, Robert T Spychal, David J Hunter-Smith
INTRODUCTION AND BACKGROUND: Three dimensional (3D) printing has gained popularity in the medical field because of increased research in the field of haptic 3D modeling. We review the role of 3D printing with specific reference to liver directed applications. METHODS: A literature search was performed using the scientific databases Medline and PubMed. We performed this in-line with the PRISMA [20] statement. We only included articles in English, available in full text, published about adults, about liver surgery and published between 2005 and 2015...
September 2016: Annals of Medicine and Surgery
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