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https://www.readbyqxmd.com/read/29446757/3d-bioprinting-mesenchymal-stem-cell-laden-construct-with-core-shell-nanospheres-for-cartilage-tissue-engineering
#1
Wei Zhu, Haitao Cui, Benchaa Boualam, Fahed Masood, Erin Flynn, Raj Rao, Zhiyong Zhang, Lijie Grace Zhang
Cartilage tissue is prone to degradation and has little capacity for self-healing due to its avascularity. Tissue engineering, which provides artificial scaffolds to repair injured tissues, is a novel and promising strategy for cartilage repair. 3D bioprinting offers even greater potential for repairing degenerative tissue by simultaneously integrating living cells, biomaterials, and biological cues to provide a customized scaffold. With regard to cell selection, mesenchymal stem cells (MSCs) hold great capacity for differentiating into a variety of cell types, including chondrocytes, and could therefore be utilized as a cartilage cell source in 3D bioprinting...
February 15, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29419675/the-precision-and-reliability-evaluation-of-3-dimensional-printed-damaged-bone-and-prosthesis-models-by-stereo-lithography-appearance
#2
Yun Zou, Qing Han, Xisheng Weng, Yongwei Zou, Yingying Yang, Kesong Zhang, Kerong Yang, Xiaolin Xu, Chenyu Wang, Yanguo Qin, Jincheng Wang
Recently, clinical application of 3D printed model was increasing. However, there was no systemic study for confirming the precision and reliability of 3D printed model. Some senior clinical doctors mistrusted its reliability in clinical application. The purpose of this study was to evaluate the precision and reliability of stereolithography appearance (SLA) 3D printed model.Some related parameters were selected to research the reliability of SLA 3D printed model. The computed tomography (CT) data of bone/prosthesis and model were collected and 3D reconstructed...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29405206/the-potential-of-3d-printing-in-urological-research-and-patient-care
#3
REVIEW
Marc Colaco, Daniel A Igel, Anthony Atala
3D printing is an evolving technology that enables the creation of unique organic and inorganic structures with high precision. In urology, the technology has demonstrated potential uses in both patient and clinician education as well as in clinical practice. The four major techniques used for 3D printing are inkjet printing, extrusion printing, laser sintering, and stereolithography. Each of these techniques can be applied to the production of models for education and surgical planning, prosthetic construction, and tissue bioengineering...
February 6, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29386555/micro-3d-printing-of-a-temperature-responsive-hydrogel-using-projection-micro-stereolithography
#4
Daehoon Han, Zhaocheng Lu, Shawn A Chester, Howon Lee
Stimuli-responsive hydrogels exhibiting physical or chemical changes in response to environmental conditions have attracted growing attention for the past few decades. Poly(N-isopropylacrylamide) (PNIPAAm), a temperature responsive hydrogel, has been extensively studied in various fields of science and engineering. However, manufacturing of PNIPAAm has been heavily relying on conventional methods such as molding and lithography techniques that are inherently limited to a two-dimensional (2D) space. Here we report the three-dimensional (3D) printing of PNIPAAm using a high-resolution digital additive manufacturing technique, projection micro-stereolithography (PμSL)...
January 31, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29378379/-biofabrication-new-approaches-for-tissue-regeneration
#5
Raymund E Horch, Annika Weigand, Harald Wajant, Jürgen Groll, Aldo R Boccaccini, Andreas Arkudas
BACKGROUND: The advent of Tissue Engineering (TE) in the early 1990ies was fostered by the increasing need for functional tissue and organ replacement. Classical TE was based on the combination of carrier matrices, cells and growth factors to reconstitute lost or damaged tissue and organs. Despite considerable results in vitro and in experimental settings the lack of early vascularization has hampered its translation into daily clinical practice so far. A new field of research, called "biofabrication" utilizing latest 3D printing technologies aims at hierarchically and spatially incorporating different cells, biomaterials and molecules into a matrix to alleviate a directed maturation of artificial tissue...
January 29, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29358527/three-dimensional-printing-in-reconstructive-oral-and-maxillofacial-surgery
#6
T Srinivasa Prasad, Govindarajan Sujatha, Jayanandan Muruganandhan, Shankargouda Patil, A Thirumal Raj
Three-dimensional (3D) printing involves the process of constructing a 3D solid object from a digital file. Charles Hull was the first to introduce 3D printer in 1983 by using the technique of stereolithography.1 Since the 1990s 3D printing has gained attention in the field of medicine where more precision is required and has largely replaced the traditional technique in prosthetic works.2,3.
January 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29328672/three-dimensional-printing-hollow-polymer-template-mediated-graphene-lattices-with-tailorable-architectures-and-multifunctional-properties
#7
Qiangqiang Zhang, Feng Zhang, Xiang Xu, Chi Zhou, Dong Lin
It is a significant challenge to concurrently achieve scalable fabrication of graphene aerogels with three-dimensional (3D) tailorable architectures (e.g., lattice structure) and controllable manipulation of microstructures on the multiscale. Herein, we highlight 3D graphene lattices (GLs) with complex engineering architectures that were delicately designed and manufactured via 3D stereolithography printed hollow polymer template-mediated hydrothermal process coupled with freeze-drying strategies. The resulting GLs with overhang beams and columns show a 3D geometric configuration with hollow-carved features at the macroscale, while the construction elements of graphene cellular on the microscale exhibit a well-ordered and honeycomb-like microstructure with high porosity...
January 12, 2018: ACS Nano
https://www.readbyqxmd.com/read/29287640/precision-and-trueness-of-dental-models-manufactured-with-different-3-dimensional-printing-techniques
#8
Soo-Yeon Kim, Yoo-Seok Shin, Hwi-Dong Jung, Chung-Ju Hwang, Hyoung-Seon Baik, Jung-Yul Cha
INTRODUCTION: In this study, we assessed the precision and trueness of dental models printed with 3-dimensional (3D) printers via different printing techniques. METHODS: Digital reference models were printed 5 times using stereolithography apparatus (SLA), digital light processing (DLP), fused filament fabrication (FFF), and the PolyJet technique. The 3D printed models were scanned and evaluated for tooth, arch, and occlusion measurements. Precision and trueness were analyzed with root mean squares (RMS) for the differences in each measurement...
January 2018: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/29279766/evaluation-of-marginal-and-internal-gap-of-three-unit-metal-framework-according-to-subtractive-manufacturing-and-additive-manufacturing-of-cad-cam-systems
#9
Dong-Yeon Kim, Eo-Bin Kim, Hae-Young Kim, Ji-Hwan Kim, Woong-Chul Kim
PURPOSE: To evaluate the fit of a three-unit metal framework of fixed dental prostheses made by subtractive and additive manufacturing. MATERIALS AND METHODS: One master model of metal was fabricated. Twenty silicone impressions were made on the master die, working die of 10 poured with Type 4 stone, and working die of 10 made of scannable stone. Ten three-unit wax frameworks were fabricated by wax-up from Type IV working die. Stereolithography files of 10 three-unit frameworks were obtained using a model scanner and three-dimensional design software on a scannable working die...
December 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29201905/evaluation-of-resins-for-stereolithographic-3d-printed-surgical-guides-the-response-of-l929-cells-and-human-gingival-fibroblasts
#10
Christoph Kurzmann, Klara Janjić, Hassan Shokoohi-Tabrizi, Michael Edelmayer, Manuela Pensch, Andreas Moritz, Hermann Agis
Additive manufacturing is becoming increasingly important in dentistry for the production of surgical guides. The development of cost-effective desktop stereolithography (SLA) printing systems and the corresponding resins makes this novel technique accessible to dental offices and dental laboratories. The aim of the study was to reveal the response of soft tissue cells to Clear and Dental SG resins used in desktop SLA printing systems at different stages of processing. Cell activity of L929 cells and gingival fibroblasts (GF) in response to the materials was examined in indirect and direct monolayer culture models and a direct spheroid culture model based on MTT, resazurin-based toxicity assays, and live-dead staining...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29171264/radiopaque-resists-for-two-photon-lithography-to-enable-submicron-3d-imaging-of-polymer-parts-via-x-ray-computed-tomography
#11
Sourabh Kumar Saha, James Spencer Oakdale, Jefferson Cuadra, Chuck Divin, Jianchao Ye, Jean-Baptiste Forien, Leonardus Bayu Aji, Juergen Biener, William Smith
Two-photon lithography (TPL) is high-resolution additive manufacturing (AM) technique capable of producing arbitrarily complex 3D micro-structures with features two to three orders of magnitude finer than a human hair. This process finds numerous applications as a direct route towards the fabrication of novel optical and mechanical metamaterials, miniaturized optics, microfluidics, biological scaffolds and various other intricate 3D parts. As TPL matures, metrology and inspection become a crucial step in the manufacturing process to ensure that the geometric form of the end-product meets design specifications...
November 24, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29170867/a-novel-fabrication-method-of-carbon-electrodes-using-3d-printing-and-chemical-modification-process
#12
Pan Tian, Chaoyang Chen, Jie Hu, Jin Qi, Qianghua Wang, Jimmy Ching-Ming Chen, John Cavanaugh, Yinghong Peng, Mark Ming-Cheng Cheng
Three-dimensional (3D) printing is an emerging technique in the field of biomedical engineering and electronics. This paper presents a novel biofabrication method of implantable carbon electrodes with several advantages including fast prototyping, patient-specific and miniaturization without expensive cleanroom. The method combines stereolithography in additive manufacturing and chemical modification processes to fabricate electrically conductive carbon electrodes. The stereolithography allows the structures to be 3D printed with very fine resolution and desired shapes...
November 23, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29156138/plasmonic-sensing-with-3d-printed-optics
#13
Samuel S Hinman, Kristy S McKeating, Quan Cheng
Three-dimensional (3D) printing has undergone an exponential growth in popularity due to its revolutionary and near limitless manufacturing capabilities. Recent trends have seen this technology utilized across a variety of scientific disciplines, including the measurement sciences, but precise fabrication of optical components for high-performance biosensing has not yet been demonstrated. We report here 3D printing of high-quality, custom prisms by stereolithography that enable Kretschmann-configured plasmonic sensing of bacterial toxins...
November 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29148121/position-accuracy-of-implant-analogs-on-3d-printed-polymer-versus-conventional-dental-stone-casts-measured-using-a-coordinate-measuring-machine
#14
Marta Revilla-León, Óscar Gonzalez-Martín, Javier Pérez López, José Luis Sánchez-Rubio, Mutlu Özcan
PURPOSE: To compare the accuracy of implant analog positions on complete edentulous maxillary casts made of either dental stone or additive manufactured polymers using a coordinate measuring machine (CMM). MATERIAL AND METHODS: A completely edentulous maxillary model of a patient with 7 implant analogs was obtained. From this model, two types of casts were duplicated, namely conventional dental stone (CDS) using a custom tray impression technique after splinting (N = 5) and polymer cast using additive manufacturing based on the STL file generated...
November 17, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29141120/biotinylated-photopolymers-for-3d-printed-unibody-lab-on-a-chip-optical-platforms
#15
Caterina Credi, Gianmarco Griffini, Marinella Levi, Stefano Turri
The present work reports the first demonstration of straightforward fabrication of monolithic unibody lab-on-a-chip (ULOCs) integrating bioactive micrometric 3D scaffolds by means of multimaterial stereolithography (SL). To this end, a novel biotin-conjugated photopolymer is successfully synthesized and optimally formulated to achieve high-performance SL-printing resolution, as demonstrated by the SL-fabrication of biotinylated structures smaller than 100 µm. By optimizing a multimaterial single-run SL-based 3D-printing process, such biotinylated microstructures are incorporated within perfusion microchambers whose excellent optical transparency enables real-time optical microscopy analyses...
November 15, 2017: Small
https://www.readbyqxmd.com/read/29125215/additive-manufacturing-a-comparative-analysis-of-dimensional-accuracy-and-skin-texture-reproduction-of-auricular-prostheses-replicas
#16
Alexey Unkovskiy, Sebastian Spintzyk, Detlef Axmann, Eva-Maria Engel, Heiner Weber, Fabian Huettig
PURPOSE: The use of computer-aided design/computer-aided manufacturing (CAD/CAM) and additive manufacturing in maxillofacial prosthetics has been widely acknowledged. Rapid prototyping can be considered for manufacturing of auricular prostheses. Therefore, so-called prostheses replicas can be fabricated by digital means. The objective of this study was to identify a superior additive manufacturing method to fabricate auricular prosthesis replicas (APRs) within a digital workflow. MATERIALS AND METHODS: Auricles of 23 healthy subjects (mean age of 37...
November 10, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29110921/3d-printed-versus-conventionally-cured-provisional-crown-and-bridge-dental-materials
#17
Anthony Tahayeri, MaryCatherine Morgan, Ana P Fugolin, Despoina Bompolaki, Avathamsa Athirasala, Carmem S Pfeifer, Jack L Ferracane, Luiz E Bertassoni
OBJECTIVES: To optimize the 3D printing of a dental material for provisional crown and bridge restorations using a low-cost stereolithography 3D printer; and compare its mechanical properties against conventionally cured provisional dental materials. METHODS: Samples were 3D printed (25×2×2mm) using a commercial printable resin (NextDent C&B Vertex Dental) in a FormLabs1+ stereolithography 3D printer. The printing accuracy of printed bars was determined by comparing the width, length and thickness of samples for different printer settings (printing orientation and resin color) versus the set dimensions of CAD designs...
October 27, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29065670/gentamicin-released-from-porous-scaffolds-fabricated-by-stereolithography
#18
Somruethai Channasanon, Pareeya Udomkusonsri, Surapol Chantaweroad, Passakorn Tesavibul, Siriporn Tanodekaew
Porous oligolactide-hydroxyapatite composite scaffolds were obtained by stereolithographic fabrication. Gentamicin was then coated on the scaffolds afterwards, to achieve antimicrobial delivery ability to treat bone infection. The scaffolds examined by stereomicroscope, SEM, and μCT-scan showed a well-ordered pore structure with uniform pore distribution and pore interconnectivity. The physical and mechanical properties of the scaffolds were investigated. It was shown that not only porosity but also scaffold structure played a critical role in governing the strength of scaffolds...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29064377/3d-printing-nano-conductive-multi-walled-carbon-nanotube-scaffolds-for-nerve-regeneration
#19
Se-Jun Lee, Wei Zhu, Margaret Nowicki, Grace Lee, Dong Nyoung Heo, Junghoon Kim, Yi Zuo, Lijie Grace Zhang
In recent years, the development of tissue-engineered 3D scaffolds for various regenerative engineering applications has been widely investigated. Hydrogel polymers are extensively used as tissue engineering scaffold materials due to their unique biocompatible features. However, hydrogel based scaffolds often suffer from weak mechanical strength and a lack of functional groups to enhance cell adhesion. Hence, nanomaterials, such as carbon nanotubes (CNTs), have been introduced to modify the surface properties of scaffolds, thus enhancing the interaction between the neural cells and biomaterials...
October 24, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29060188/visible-light-based-stereolithography-bioprinting-of-cell-adhesive-gelatin-hydrogels
#20
Zongjie Wang, Zhenlin Tian, Xian Jin, Jonathan F Holzman, Frederic Menard, Keekyoung Kim
Stereolithography-based bioprinting offers advantages in resolution and rapid printing time, and thus has received major attention in recent years. However, traditional stereolithography-based bioprinting utilizes an ultraviolet light which may cause mutagenesis and carcinogenesis of cells. In this paper, we present a new visible light crosslinkable bioink that is based on cell-adhesive gelatin. The bioink consists of Eosin Y (EY) based photoinitiator and gelatin methacrylate (GelMA) pre-polymer solution. We examined the feasibility of using visible light from a commercial beam projector to pattern the EY-GelMA bioink...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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