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pediatric seizures

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https://www.readbyqxmd.com/read/29777883/atypical-presentation-of-giant-aneurysm-in-a-pediatric-patient-with-duane-syndrome
#1
Chao-Hung Kuo, Lynn B McGrath, Joseph A Carnevale, Neena I Marupudi, Jeffery G Ojemann, Richard G Ellenbogen, Anthony C Wang
BACKGROUND: Duane syndrome is a congenital eye movement disorder characterized by congenital malformation of the abducens nucleus. Thrombogenic conditions during development may lead to vascular anomalies in Duane syndrome, however, the presence of a giant aneurysm in this patient population is a rarely documented phenomenon. CASE DESCRIPTION: We reported a case of a large cerebral aneurysm in a pediatric patient with Duane syndrome, and performed a review of the literatures to identify other potential cases and associations...
May 16, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29766748/medical-cannabis-for-pediatric-moderate-to-severe-complex-motor-disorders
#2
Stephanie Libzon, Lihi Bar-Lev Schleider, Naama Saban, Luda Levit, Yulia Tamari, Ilan Linder, Tally Lerman-Sagie, Lubov Blumkin
A complex motor disorder is a combination of various types of abnormal movements that are associated with impaired quality of life (QOL). Current therapeutic options are limited. We studied the efficacy, safety, and tolerability of medical cannabis in children with complex motor disorder. This pilot study was approved by the institutional ethics committee. Two products of cannabidiol (CBD) enriched 5% oil formulation of cannabis were compared: one with 0.25% δ-9-tetrahydrocannabinol (THC) 20:1 group, the other with 0...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29763644/immunomodulatory-effect-of-celecoxib-on-hmgb1-tlr4-pathway-in-a-recurrent-seizures-model-in-immature-rats
#3
Mariana Morales-Sosa, Sandra Orozco-Suárez, AngélicaVega-García, Sara Caballero-Chacón, Iris A Feria-Romero
Epileptic seizures constitute an important problem in pediatric neurology during the developmental period. The frequency and nosological significance of seizures, as well as their association with epileptogenesis, may be related to underlying mechanisms such as neuroinflammation. Those mechanisms of response activate inflammatory molecules induced in the neurons, activated glial cells and endothelial cells via the key HMGB1/TLR4 pathway. In this study, the drug celecoxib (CCX) was used as a blocker of the cyclooxygenase 2 (COX-2) and HMGB1/TLR-4 pathways...
May 12, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29761351/economic-evaluation-of-stiripentol-for-dravet-syndrome-a-cost-utility-analysis
#4
Jesse Elliott, Bláthnaid McCoy, Tammy Clifford, George A Wells, Doug Coyle
BACKGROUND: Dravet syndrome is a catastrophic form of pediatric treatment-resistant epilepsy with few effective treatment options. Stiripentol is approved for use in Canada for treatment of Dravet syndrome, but the associated long-term costs and benefits have not been well-studied and its cost effectiveness is unclear. OBJECTIVE: The aim of this study was to evaluate the cost effectiveness of stiripentol as an adjunctive treatment to clobazam and valproate for treatment of Dravet syndrome from the perspective of the Canadian public healthcare payer...
May 15, 2018: PharmacoEconomics
https://www.readbyqxmd.com/read/29760852/altered-mental-status-current-evidence-based-recommendations-for-prehospital-care
#5
REVIEW
Ashley Sanello, Marianne Gausche-Hill, William Mulkerin, Karl A Sporer, John F Brown, Kristi L Koenig, Eric M Rudnick, Angelo A Salvucci, Gregory H Gilbert
Introduction: In the United States emergency medical services (EMS) protocols vary widely across jurisdictions. We sought to develop evidence-based recommendations for the prehospital evaluation and treatment of a patient with an acute change in mental status and to compare these recommendations against the current protocols used by the 33 EMS agencies in the State of California. Methods: We performed a literature review of the current evidence in the prehospital treatment of a patient with altered mental status (AMS) and augmented this review with guidelines from various national and international societies to create our evidence-based recommendations...
May 2018: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29754012/clinical-spectrum-of-psychogenic-non-epileptic-seizures-in-children-an-observational-study
#6
Priyanka Madaan, Sheffali Gulati, Biswaroop Chakrabarty, Savita Sapra, Rajesh Sagar, Akbar Mohammad, R M Pandey, Manjari Tripathi
PURPOSE: The current study was designed to analyze the clinical spectrum of Psychogenic non-epileptic seizures (PNES) in children. METHODS: Children aged 6-16years with clinically suspected PNES, confirmed by short-term VEEG (STVEEG{video electroencephalogram}) and induction were classified as per Seneviratne classification. Stressors, associated co morbidities, Verbal IQ (Intelligence Quotient) and behavioral abnormalities were assessed using HTP(House tree person) test, DSM IV (Diagnostic and statistical manual of mental disorders) TR criteria, MISIC (Malin intelligence scale for Indian children) and CBCL (Child behaviour checklist)...
April 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29753574/corrigendum-to-complications-during-ketogenic-diet-initiation-prevalence-treatment-and-influence-on-seizure-outcomes-pediatr-neurol-68-2017-35-39
#7
Abigail Lin, Zahava Turner, Sarah C Doerrer, Anthony Stanfield, Eric H Kossoff
No abstract text is available yet for this article.
May 9, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29753573/impact-of-prior-authorization-of-antiepileptic-drugs-in-children-with-epilepsy
#8
Elaine C Wirrell, Alexander J Vanderwiel, Lauren Nickels, Saskia L Vanderwiel, Katherine C Nickels
OBJECTIVE: We assessed how commonly prior authorization results in treatment delay or missed doses in children with epilepsy. METHODS: Parents of 462 children followed in a pediatric epilepsy clinic were surveyed regarding prior authorization in the preceding year. Epilepsy and insurance details were collected. If prior authorization was required, parents were asked whether it resulted in (1) delayed initiation of a newly-prescribed antiepileptic drug, and/or (2) lapse in coverage of a current medication...
April 3, 2018: Pediatric Neurology
https://www.readbyqxmd.com/read/29753075/pigmented-ganglioglioma-of-the-cerebellum-case-report-and-review
#9
Mohit Agrawal, Sachin A Borkar, Gaurav Khanna, Mehar C Sharma, Shashank S Kale
BACKGROUND: Gangliogliomas are rare intra-axial tumors. Cerebellar seizures caused by gangliogliomas have been rarely described. Pigmented neural cell tumors are well described in the literature but infrequent, especially when presenting as primary neuroepithelial tumors. Only five cases of pigmented ganglioglioma have been described in literature, out of which 4 were in the pediatric population. CASE DESCRIPTION: A seventeen year old female presented to us with cerebellar seizures, which resolved after tumor excision...
May 9, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29747930/baseline-and-outcome-assessment-in-pediatric-status-epilepticus
#10
REVIEW
Saba Jafarpour, Coral M Stredny, Juan Piantino, Kevin E Chapman
PURPOSE: To summarize different aspects of short and long-term outcomes associated with SE, including mortality, recurrence, subsequent epilepsy, neurocognitive dysfunction, imaging abnormalities, and health-related quality of life. METHODS: We searched MEDLINE for studies that assessed the short-term and long-term outcome of status epilepticus in pediatric population, including mortality, recurrence of seizure and status epilepticus, neurological, cognitive, or behavioral impairment, and health-related quality of life...
April 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29747021/adaptive-nocturnal-seizure-detection-using-heart-rate-and-low-complexity-novelty-detection
#11
Thomas De Cooman, Carolina Varon, Anouk Van de Vel, Katrien Jansen, Berten Ceulemans, Lieven Lagae, Sabine Van Huffel
PURPOSE: Automated seizure detection at home is mostly done using either patient-independent algorithms or manually personalized algorithms. Patient-independent algorithms, however, lead to too many false alarms, whereas the manually personalized algorithms typically require manual input from an experienced clinician for each patient, which is a costly and unscalable procedure and it can only be applied when the patient had a sufficient amount of seizures. We therefore propose a nocturnal heart rate based seizure detection algorithm that automatically adapts to the patient without requiring seizure labels...
April 26, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29746397/impact-of-drug-interactions-on-clobazam-and-n-desmethylclobazam-concentrations-in-pediatric-patients-with-epilepsy
#12
Gabrielle R Russell, Stephanie J Phelps, Chasity M Shelton, James W Wheless
BACKGROUND: Clobazam (CLB) is approved as adjunctive treatment for seizures associated with Lennox-Gastaut syndrome in patients ≥2 years of age. It is converted to an active metabolite N-desmethylclobazam (NCLB) by CYP3A4, which is then broken down to an inactive metabolite by CYP2C19. This study characterizes the impact of CYP3A4 and CYP2C19 drug interactions on CLB and NCLB serum concentrations (Cp) and concentration/dose (Cp/D) ratios in pediatric patients with epilepsy. METHODS: This was a retrospective chart review including patients >1 month of age, who received CLB between April 2012 and March 2017...
May 4, 2018: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29733235/pharmacological-management-of-symptoms-in-children-with-life-limiting-conditions-at-the-end-of-life-in-the-asia-pacific
#13
Lee Ai Chong, Poh Heng Chong, Joyce Chee
BACKGROUND: The provision of pediatric palliative care in Asia Pacific varies between countries and availability of essential medications for symptoms at the end of life in this region is unclear. OBJECTIVE: To determine medications available and used in the management of six symptoms at the end of life among pediatric palliative care practitioners in Asia Pacific. To identify alternative pharmacological strategies for these six symptoms if the oral route was no longer possible and injections are refused...
May 7, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29732137/anaplasic-astrocytoma-with-exophytic-growth-in-sylvian-fissure-in-a-pediatric-patient-a-case-report
#14
José Raúl Guerra-Mora, Ulises Bravo-Ángel, Rodrigo Efraín Hernández-Reséndiz, Rosa María Vicuña-González, Jessica Frías-Guillén, Irina Jeanette Bercholc-Urinowsky, Carlos Cesar Bravo-Reyna, Ulises García-González
Gliomas are the most frequent supratentorial intracranial tumors in the pediatric population. Usually, they are intra-axial lesions with a characteristic image pattern, however, there are few reported cases of gliomas with exophytic growth. There are no previous reports in the literature of gliomas with exophytic growth in the Sylvian fissure. Fourteen year-old female patient who started with seizures. In imaging studies, a neoplasic mass with an exophytic portion in the left Sylvian fissure was found. Macroscopically, total resection was performed, definitive diagnosis was anaplastic astrocytoma...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29731400/treatment-of-infantile-spasms-by-pediatric-neurologists-in-japan
#15
Shin-Ichiro Hamano, Toshisaburo Nagai, Ryuki Matsuura, Yuko Hirata, Satoru Ikemoto, Atsuko Oba, Erika Hiwatari
OBJECTIVE: To clarify changes in clinical practice for infantile spasms, including West syndrome, in Japan over the past two decades. METHODS: We investigated common treatment strategies for infantile spasms among 157 pediatric neurologists from a designated training facility for pediatric neurology and/or a designated training facility for epilepsy in Japan. A questionnaire was used to investigate use of adrenocorticotropic hormone (ACTH) therapy including daily dose, treatment duration, and tapering off period, and preferred first to fifth-line treatment choices...
May 3, 2018: Brain & Development
https://www.readbyqxmd.com/read/29729532/how-do-we-diagnose-and-treat-epilepsy-with-myoclonic-atonic-seizures-doose-syndrome-results-of-the-pediatric-epilepsy-research-consortium-survey
#16
Katherine Nickels, Ronald Thibert, Stephanie Rau, Scott Demarest, Elaine Wirrell, Eric H Kossoff, Charuta Joshi, Srishti Nangia, Renee Shellhaas
OBJECTIVE: To obtain and assess opinions on EMAS diagnostic criteria, recommended investigations, and therapeutic options, from a large group of physicians who care for children with EMAS. METHODS: The EMAS focus group of PERC created a survey to assess the opinions of pediatric neurologists who care for children with EMAS regarding diagnosis and treatment of this condition, which was sent to members of PERC, AES, and CNS. A Likert scale was used to assess the respondents' opinions on the importance of diagnostic and exclusion criteria (five point scale), investigations (four point scale), and treatment (six point scale) of EMAS...
April 25, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29727818/efficacy-and-safety-of-ketogenic-diet-for-treatment-of-pediatric-convulsive-refractory-status-epilepticus
#17
Ravindra Arya, Katrina Peariso, Marina Gaínza-Lein, Jessica Harvey, Ann Bergin, J Nicholas Brenton, Brian T Burrows, Tracy Glauser, Howard P Goodkin, Yi-Chen Lai, Mohamad A Mikati, Iván Sánchez Fernández, Dmitry Tchapyjnikov, Angus A Wilfong, Korwyn Williams, Tobias Loddenkemper
PURPOSE: To describe the efficacy and safety of ketogenic diet (KD) for convulsive refractory status epilepticus (RSE). METHODS: RSE patients treated with KD at the 6/11 participating institutions of the pediatric Status Epilepticus Research Group from January-2011 to December-2016 were included. Patients receiving KD prior to the index RSE episode were excluded. RSE was defined as failure of ≥2 anti-seizure medications, including at least one non-benzodiazepine drug...
April 27, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29727742/cytokine-levels-in-febrile-seizure-patients-a-systematic-review-and-meta-analysis
#18
Aram Kwon, Byung Ok Kwak, Kyungmin Kim, Jongseok Ha, Soo-Jin Kim, Sun Hwan Bae, Jae Sung Son, Soo-Nyung Kim, Ran Lee
PURPOSE: Febrile seizures (FSs) are the most common form of childhood seizures. During infection, both pro-inflammatory and anti-inflammatory cytokines are produced. Complex interactions among immune-inflammatory process, cytokine activation, and genetic factors are involved in the pathogenesis of FSs. The association between cytokines and FSs during childhood is inconclusive due to inconsistent results reported in different studies. We performed a systematic review and meta-analysis to determine an association between cytokines and FS in children...
April 27, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29725488/serum-procalcitonin-levels-in-acute-encephalopathy-with-biphasic-seizures-and-late-reduced-diffusion
#19
Yosuke Fujii, Masato Yashiro, Mutsuko Yamada, Tomonobu Kikkawa, Nobuyuki Nosaka, Yukie Saito, Kohei Tsukahara, Masanori Ikeda, Tsuneo Morishima, Hirokazu Tsukahara
Procalcitonin (PCT) is used as a biomarker in severe infections. Here, we retrospectively investigated levels of serum PCT, C-reactive protein (CRP), and inflammatory cytokines (IL-6, TNF- α , and IFN- γ ) in the second phase of patients with acute encephalopathy with biphasic seizures and late reduced diffusion (AESD). Nine AESD pediatric patients (4 men, 5 women; AESD group) admitted to Okayama University Hospital from 2010 to 2016 were compared with 10 control patients with febrile seizures (FS) (3 men, 7 women; FS group)...
2018: Disease Markers
https://www.readbyqxmd.com/read/29717350/pediatric-intracranial-aneurysms-changes-from-previous-studies
#20
Ruiqi Chen, Si Zhang, Chao You, Rui Guo, Lu Ma
PURPOSE: To develop a better understanding of pediatric intracranial aneurysms (PIAs). METHODS: All PIAs treated in our center from January 2012 to April 2017 were retrospectively included. Clinical data, treatment summaries, and follow-up outcomes were retrieved and analyzed. RESULTS: A total of 66 PIAs were found in 64 patients with a mean age of 11.4 ± 5.7 years, 68.8% of whom were male. The most common symptoms were seizure (n = 7, 63...
May 2, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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