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Silicon nanoparticles

Simo Näkki, Jonathan Martinez, Michael Evangelopoulos, Wujun Xu, Vesa-Pekka Lehto, Ennio Tasciotti
Approaches to achieve site-specific and targeted delivery that provide an effective solution to reduce negative, off target side-effects are urgently needed for cancer therapy. Here, we utilized a Trojan horse-like strategy to carry photosensitizer Chlorin e6 conjugated porous silicon multistage nanovectors with tumor homing mesenchymal stem cells for targeted photodynamic therapy and diagnosis. The inherent versatility of multistage nanovectors permitted the conjugation of photosensitizers to enable precise cell death induction (60%) upon photodynamic therapy, while simultaneously retaining the loading capacity to load various payloads, such as antitumor drugs and diagnostic nanoparticles...
June 22, 2017: ACS Applied Materials & Interfaces
Tomonobu Uchino, Yasunori Miyazaki, Takuto Yamazaki, Yoshiyuki Kagawa
OBJECTIVE: In this study, we aimed to investigate the immunogenicity of protein aggregates of monoclonal antibodies (mAbs), generated by forced shaking stress with siliconized and nonsiliconized syringes in a mouse model. METHODS: Samples were filled in siliconized and nonsiliconized syringes with shaking and headspace air. Characterization studies were performed using high-performance size-exclusion chromatography, nanoparticle tracking analysis, flow cytometry, micro-flow imaging and resonant mass measurement...
June 21, 2017: Journal of Pharmacy and Pharmacology
Lili Zhang, Dong-Ming Sun, Peng-Xiang Hou, Chang Liu, Tianyuan Liu, Jianfeng Wen, Nujiang Tang, Jian Luan, Chao Shi, Jin-Cheng Li, Hong-Tao Cong, Hui-Ming Cheng
A major obstacle for the use of single-wall carbon nanotubes (SWCNTs) in electronic devices is their mixture of different types of electrical conductivity that strongly depends on their helical structure. The existence of metal impurities as a residue of a metallic growth catalyst may also lower the performance of SWCNT-based devices. Here, it is shown that by using silicon oxide (SiOx ) nanoparticles as a catalyst, metal-free semiconducting and metallic SWCNTs can be selectively synthesized by the chemical vapor deposition of ethanol...
June 21, 2017: Advanced Materials
Jinhui Zhu, Jun Yang, Zhixin Xu, Jiulin Wang, Yanna Nuli, Xiaodong Zhuang, Xinliang Feng
Silicon (Si) anodes, which are among the most promising candidates for high-energy lithium-ion batteries (LIBs), have attracted considerable attention from both academic and industrial communities. However, Si anodes usually suffer from an inherently low conductivity and extremely large volume change during the lithiation and delithiation processes, and consequently exhibit an inferior rate capability and poor cycle life. In this paper, we report new porous polymer-derived carbon coated Si nanoparticles (NPs) as the next generation anodes for LIBs to overcome these serious problems...
June 20, 2017: Nanoscale
Huan Min, Jun Zhou, Xiaojue Bai, Linlin Li, Kai Zhang, Tieqiang Wang, Xuemin Zhang, Yunong Li, Yonghua Jiao, Xuan Qi, Yu Fu
We report a facile method to fabricate a compact Au nanoparticles film with the assistance of surfactants. First, the dodecanethiol-coated Au nanoparticles were floated on the surface of the toluene/acetonitrile mixture solvent and adjusted to an expanded dispersion by changing the mixture ratio. The silicone oil was then added as a surfactant to compress the floating nanoparticles from the original loose status to a closely-packed arrangement which produced a compact nanoparticle film. The relationship of the compressed film area with the silicone oil concentration was plotted and compared with the surface tension curve of silicone oil...
June 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Sangyul Baik, Da Wan Kim, Youngjin Park, Tae-Jin Lee, Suk Ho Bhang, Changhyun Pang
Adhesion strategies that rely on mechanical interlocking or molecular attractions between surfaces can suffer when coming into contact with liquids. Thus far, artificial wet and dry adhesives have included hierarchical mushroom-shaped or porous structures that allow suction or capillarity, supramolecular structures comprising nanoparticles, and chemistry-based attractants that use various protein polyelectrolytes. However, it is challenging to develop adhesives that are simple to make and also perform well-and repeatedly-under both wet and dry conditions, while avoiding non-chemical contamination on the adhered surfaces...
June 14, 2017: Nature
Ozlem Yavas, Mikael Svedendahl, Paulina Dobosz, Vanesa Sanz, Romain Quidant
Nanophotonics has become a key enabling technology in biomedicine with great promises in early diagnosis and less invasive therapies. In this context, the unique capability of plasmonic noble metal nanoparticles to concentrate light on the nanometer scale has widely contributed to biosensing and enhanced spectroscopy. Recently, high-refractive index dielectric nanostructures featuring low loss resonances have been proposed as a promising alternative to nanoplasmonics, potentially offering better sensing performances along with full compatibility with the microelectronics industry...
June 16, 2017: Nano Letters
Ekram Wassel, Martha Es-Souni, Nele Berger, Dimitri Schopf, Matthias Dietze, Claus-Henning Solterbeck, Mohammed Es-Souni
We explore the suitability of nanocomposite thin films based on the laponite nanomaterial and grafted anti-adhesive polymers as transparent non-fouling surfaces. For this purpose two polymers were chosen, a linear PEG silane, 2-[Methoxy(polyethyleneoxy)propyl]-trimethoxysilane), and thermo-responsive poly(oligo ethyleneglycol)-methylether-methacrylate (POEGMA) brushes. PEG silane was grafted on the laponite nanoparticles in solution yielding homogenous and transparent thin films via a dip coating procedure on glass and silicon substrates...
June 12, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Virginija Jankauskaitė, Algirdas Lazauskas, Egidijus Griškonis, Aistė Lisauskaitė, Kristina Žukienė
The most effective means to protect against bacterial invasion and to reduce the risk of healthcare-associated infections are antibacterial components synthesis. In this study, a novel process for the synthesis of organic-inorganic hybrid coatings containing silver nanoparticles is presented. Silver nanoparticles and polymer formation proceeds simultaneously through the in situ photoreduction of silver salt to silver nanoparticles and UV-crosslinking of bifunctional aliphatic silicone acrylate. The nanocomposite films with 0...
June 9, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Shicheng Yan, Zhe Xu, Zhan Shi, Lang Pei, Zhengbin Gu, Zhigang Zou
One main barrier for enhancing solar energy conversion by photoelectrochemical (PEC) water splitting devices is the charge separation and transport efficiency at the interface region of the photoanode and electrolyte. Here, we electrodeposited the core-shell structured Ni@Ni(OH)2 nanoparticles on the surface of n-type Si photoanode with island distribution. We found that the Schottky barrier between Ni and Si is sensitive to the thickness of Ni(OH)2 shell. The photovoltage output of the photoanode increases with increasing the thickness of Ni(OH)2 shell, closely associating with the interaction between Ni and Ni(OH)2 that depends on the electrolyte screening effect and p-type feature of Ni(OH)2 layer...
June 6, 2017: ChemSusChem
Yuichi Kato, Masashi Kikugawa, Eiichi Sudo
The application of attenuated total reflection surface-enhanced infrared absorption spectroscopy (ATR SEIRA) to the analysis of fatty acids on silver nanoparticles was investigated. Attenuated total reflection measurements using four types of internal reflection elements (IREs)-zinc selenide, diamond, silicon, and germanium-were performed for silver nanoparticles modified with fatty acids, and germanium IRE was shown to be suitable for the analysis of silver nanoparticles, even when the sample had a high refractive index...
January 1, 2017: Applied Spectroscopy
A R Harikrishnan, Purbarun Dhar, Prabhat K Agnihotri, Sateesh Gedupudi, Sarit Kumar Das
Even though there are quite large studies on wettability of aqueous surfactants and a few studies on effects of nanoparticles on wettability of colloids, to the best of authors' knowledge, there is no study reported on the combined effect of surfactant and nanoparticles in altering the wettability. The present study, for the first time, reports an extensive experimental and theoretical study on the combined effect of surfactants and nanoparticles on the wettability of complex fluids such as nanocolloids on different substrates, ranging from hydrophilic with a predominantly polar surface energy component (silicon wafer and glass) to near hydrophobic range with a predominantly dispersive component of surface energy (aluminum and copper substrates)...
June 12, 2017: Journal of Physical Chemistry. B
Ruggero Verre, Lei Shao, Nils Odebo Länk, Pawel Karpinski, Andrew B Yankovich, Tomasz J Antosiewicz, Eva Olsson, Mikael Käll
High-refractive-index silicon nanoresonators are promising low-loss alternatives to plasmonic particles in CMOS-compatible nanophotonics applications. However, complex 3D particle morphologies are challenging to realize in practice, thus limiting the range of achievable optical functionalities. Using 3D film structuring and a novel gradient mask transfer technique, the first intrinsically chiral dielectric metasurface is fabricated in the form of a monolayer of twisted silicon nanocrescents that can be easily detached and dissolved into colloidal suspension...
June 6, 2017: Advanced Materials
A Shavel, L Guerrini, R A Alvarez-Puebla
Silicon nanoparticles are unique materials with applications in a variety of fields, from electronics to catalysis and biomedical uses. Despite technological advancements in nanofabrication, the development of a simple and inexpensive route for the synthesis of homogeneous silicon nanoparticles remains highly challenging. Herein, we describe a new, simple and inexpensive colloidal synthetic method for the preparation, under normal pressure and mild temperature conditions, of relatively homogeneous spherical silicon nanoparticles of either ca...
June 5, 2017: Nanoscale
Łukasz John, Mateusz Janeta, Sławomir Szafert
In this paper, we report on synthesis and characterization of three-dimensional biocomposite based on a polymerized 3-(trimethoxysilyl)propyl methacrylate/ethylene glycol dimethacrylate (pTMSPMA/pEGDMA) framework. The resulting composite was doped with Ca(2+) and PO4(3-) or decorated by hydroxyapatite (HA) and carbonate hydroxyapatite (CHA) to aid potential bone fixation and the in vitro bioactivity was evaluated. During the construction of the macroporous scaffold, the size and shape of pores were modified depending on the type of porogens which was applied (commercially available sugar, NaCl, or NH4Cl)...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
Qian-Long Wang, Jie Li, Xing-De Li, Wan-Jun Tao, Li-Sheng Ding, Pei Luo, Lin-Sen Qing
A simple, fast, and highly sensitive direct competitive enzyme-linked immunosorbent assay (ELISA) based on bovine serum albumin (BSA) antigen labeled amine-terminated silicon dioxide (SiO2-NH-BSA) nanoparticles was developed to determine residual BSA in vaccines. As nano-ELISA using nanomaterials with a very high surface-to-volume ratio has emerged as a promising strategy, SiO2-NH-BSA nanoparticles were prepared in this study by the coupling of BSA to SiO2 nanoparticles modified with amidogen, followed by the quantification of BSA via a direct competitive binding of BSA-antigen-labeled SiO2 nanoparticles to anti-BSA antibody conjugated with horseradish peroxidase...
June 2, 2017: Analytical and Bioanalytical Chemistry
Zhiliang Liu, Xinghua Chang, Teng Wang, Wei Li, Haidong Ju, Xinyao Zheng, Xiuqi Wu, Cong Wang, Jie Zheng, Xingguo Li
Silica can be converted to silicon by magnesium reduction. Here, this classical reaction is renovated for more efficient preparation of silicon nanoparticles (nano-Si). By reducing the particle size of the starting materials, the reaction can be completed within 10 min by mechanical milling at ambient temperature. The obtained nano-Si with high surface reactivity are directly reacted with 1-pentanol to form an alkoxyl-functionalized hydrophobic colloid, which significantly simplifies the separation process and minimizes the loss of small Si particles...
June 7, 2017: ACS Nano
Anna Cifuentes-Rius, Angela Ivask, Ester Sporleder, Ishdeep Kaur, Yasmin Assan, Shasha Rao, David Warther, Clive A Prestidge, Jean-Olivier Durand, Nicolas H Voelcker
There is a pressing need to develop more effective therapeutics to fight cancer. An idyllic chemotherapeutic is expected to overcome drug resistance of tumors and minimize harmful side effects to healthy tissues. Antibody-functionalized porous silicon nanoparticles loaded with a combination of chemotherapy drug and gold nanoclusters (AuNCs) are developed. These nanocarriers are observed to selectively deliver both payloads, the chemotherapy drug and AuNCs, to human B cells. The accumulation of AuNCs to target cells and subsequent exposure to an external electromagnetic field in the microwave region render them more susceptible to the codelivered drug...
June 1, 2017: Small
Zewen Zuo, Yibing Wen, Sheng Zhang, Jun Qu, Guanglei Cui, Yi Shi
Gold nanospheres (AuNSs) were partly embedded into silicon through metal-assisted chemical etching, producing multiple-dimensional coupling of the plasmon resonances with the induced image charges in the surrounding medium. Rich plasmonic features of such coupling system were revealed by single particle dark-field scattering spectra, characterizing by two splitted multipolar resonances at short wavelength region and a mixed dipolar resonance extending to infrared region. Numerical electrodynamic calculations indicated that the multipolar modes arise from the in-plane and out-of-plane quadrupolar resonances, which are excited by the horizontal and verticle electric field components, respectively, of the incident light owing to the enhanced coupling interaction...
May 31, 2017: Nanotechnology
Lauri J Reuter, Mohammad-Ali Shahbazi, Ermei M Mäkilä, Jarno J Salonen, Reza Saberianfar, Rima Menassa, Hélder A Santos, Jussi J Joensuu, Anneli Ritala
The encapsulation of drugs to nanoparticles may offer a solution for targeted delivery. Here, we set out to engineer a self-assembling targeting ligand by combining the functional properties of human transferrin and fungal hydrophobins in a single fusion protein. We showed that human transferrin can be expressed in Nicotiana benthamiana plants as a fusion with Trichoderma reesei hydrophobins HFBI, HFBII, or HFBIV. Transferrin-HFBIV was further expressed in tobacco BY-2 suspension cells. Both partners of the fusion protein retained their functionality; the hydrophobin moiety enabled migration to a surfactant phase in an aqueous two-phase system, and the transferrin moiety was able to reversibly bind iron...
June 21, 2017: Bioconjugate Chemistry
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