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https://www.readbyqxmd.com/read/29780484/exploiting-the-interactions-between-the-ruthenium-hoveyda-grubbs-catalyst-and-al-modified-mesoporous-silica-the-case-of-sba15-vs-kcc-1
#1
Baraa Werghi, Eva Pump, Mykyta Tretiakov, Edy Abou-Hamad, Andrei Gurinov, Pradeep Doggali, Dalaver H Anjum, Luigi Cavallo, Anissa Bendjeriou-Sedjerari, Jean-Marie Basset
Immobilization of the 2nd generation Hoveyda-Grubbs catalyst HG-II onto well-ordered 2D hexagonal (SBA15) and 3D fibrous (KCC-1) mesostructured silica, which contained tetra-coordinated Al, has been investigated through the Surface Organometallic Chemistry (SOMC) methodology. The main interest of this study lies in the peculiarity of the silica supports, which display a well-defined tetrahedral aluminum hydride site displaying a strong Lewis acid character, [( 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 Si-O-Si 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 )( 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 11111111111111111 11111111111111111 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 00000000000000000 Si-O-)2 Al-H]...
April 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29775537/amplification-of-dynamic-nuclear-polarization-at-200-ghz-by-arbitrary-pulse-shaping-of-the-electron-spin-saturation-profile
#2
Ilia Kaminker, Songi Han
Dynamic nuclear polarization (DNP) takes center stage in nuclear magnetic resonance (NMR) as a tool to amplify its signal by orders of magnitude through the transfer of polarization from electron to nuclear spins. In contrast to modern NMR and electron paramagnetic resonance (EPR) that extensively rely on pulses for spin manipulation in the time domain, the current mainstream DNP technology exclusively relies on monochromatic continuous wave (CW) irradiation. This study introduces arbitrary phase shaped pulses that constitute a train of coherent chirp pulses in the time domain at 200 GHz (7 Tesla) to dramatically enhance the saturation bandwidth and DNP performance compared to CW DNP, yielding up to 500-fold in NMR signal enhancements...
May 18, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29770999/paramagnetic-metal-ion-dopants-as-polarization-agents-for-dnp-nmr-spectroscopy-in-inorganic-solids
#3
Tanmoy Chakrabrty, Nir Goldin, Akiva Feintuch, Lothar Houben, Michal Leskes
Dynamic nuclear polarization (DNP), a technique in which the high electron spin polarization is transferred to surrounding nuclei via microwaves irradiation, equips solid state NMR spectroscopy with unprecedented sensitivity. The most commonly used polarization agents for DNP are nitroxide radicals. However, their applicability to inorganic materials is mostly limited to surface detection. Paramagnetic metal ions were recently introduced as alternatives for nitroxides. Doping inorganic solids with paramagnetic ions can be used to tune material properties and introduces endogenous DNP agents that can potentially provide sensitivity in the particles' bulk and surface...
May 17, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29759181/ultrasensitive-detection-of-thiophenol-based-on-a-water-soluble-pyrenyl-probe
#4
Zhiyi Yao, Wenqi Ge, Mingwei Guo, Keren Xiao, Yadong Qiao, Zhong Cao, Hai-Chen Wu
We report a simple pyrene-based fluorescent probe, sodium 8-(2,4-dinitrophenoxy)pyrene-1,3,6-trisulfonate (HPTS-DNP), for the ultrasensitive and visual detection of thiophenol in 100% aqueous media. The sensing mechanism of this method is based on nucleophilic aromatic substitution on HPTS-DNP caused by thiophenol to afford a highly fluorescent product, 8-hydroxypyrene-1,3,6-trisulfonic acid trisodium salt (HPTS). The extremely low fluorescence background of HPTS-DNP and high quantum yield of HPTS ensure the superior sensing performance toward thiophenol, including rapid responses, off-on detection mode and excellent sensitivity...
August 1, 2018: Talanta
https://www.readbyqxmd.com/read/29756781/frequency-swept-integrated-and-stretched-solid-effect-dnp
#5
Thach Van Can, Johannes E McKay, Ralph T Weber, Chen Yang, Thierry Dubroca, Johan Van Tol, Stephen Hill, Robert G Griffin
We investigate a new time domain approach to dynamic nuclear polarization (DNP), the frequency-swept integrated solid effect (FS-ISE), utilizing a high power, broadband 94 GHz (3.35 T) pulse EPR spectrometer. The bandwidth of the spectrometer enabled measurement of the DNP Zeeman frequency/field profile that revealed two dominant polarization mechanisms, the expected ISE, and a new mechanism the stretched solid effect (S2E). At 94 GHz, despite the limitations in the microwave chirp pulse length (10 μs) and the repetition rate (2 kHz), we obtained signal enhancements up ~70 for the S2E and ~50 for the ISE...
May 14, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29746355/relationships-among-dnp-and-phd-students-after-implementing-a-doctoral-student-organization
#6
Jasmine L Travers, Marjorie Weis, Jacqueline A Merrill
BACKGROUND: Early career contact, between clinically focused DNP and research-focused PhD nursing students, may encourage desirable intradisciplinary synergies. AIM: The aim of the study was to assess relationships among DNP and PhD nursing students after initiating a doctoral student organization. METHOD: An online survey assessed student interaction pre- and post-doctoral student organization implementation. Analysis consisted of paired t-test, social network analysis, and content analysis methods...
May 9, 2018: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29741214/efficiency-of-water-soluble-nitroxide-biradicals-for-dynamic-nuclear-polarization-in-rotating-solids-at-9-4-t-bctol-m-and-cyolyl-totapol-as-new-polarizing-agents
#7
Michel Geiger, Anil Jagtap, Monu Kaushik, Han Sun, Daniel Stöppler, Snorri Sigurdsson, Björn Corzilius, Hartmut Oschkinat
Nitroxide biradicals are very efficient polarizing agents in magic angle spinning (MAS) cross effect (CE) dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR). Many recently synthesized, new radicals show superior DNP-efficiency in organic solvents but suffer from insufficient solubility in water or glycerol/water for biological applications. We report DNP efficiencies for two new radicals, the particularly well-water soluble bcTol-M and cyolyl-TOTAPOL, and include a comparison with three known biradicals, TOTAPOL, bcTol, and AMUPol...
May 9, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29739451/reflex-erection-in-the-rat-reciprocal-interplay-between-hemodynamic-and-somatic-events
#8
Alexander Andreev-Andrievskiy, Evgeniia Lagereva, Anfisa Popova
BACKGROUND: Penile erection is a complex reflex under spinal control and modulated by the brain. The hemodynamic events under autonomic control and the perineal muscles somatic activity are interconnected during the reflex erection at the spinal level, however if the afferent feedback on the corpus cavernosum pressure during an erection affects the somatic activity (perineal muscles contractions) and vice versa is not known. This study was aimed to test this hypothesis using a rat model...
May 8, 2018: BMC Urology
https://www.readbyqxmd.com/read/29731723/would-you-use-it-with-a-seal-of-approval-important-attributes-of-2-4-dinitrophenol-2-4-dnp-as-a-hypothetical-pharmaceutical-product
#9
Emma E Bleasdale, Sam N Thrower, Andrea Petróczi
Background: 2,4-Dinitrophenol (2,4-DNP) is an effective but highly dangerous fat burner, not licensed for human consumption. Death cases reported for 2,4-DNP overdose, particularly among young adults, have raised concerns about the ineffective regulatory control, lack of education and risks associated with impurity, and the unknown concentration of 2,4-DNP purchased on the Internet. Methods: Using a sequential mixed method design and based on a hypothetical scenario as if 2,4-DNP was a licensed pharmaceutical drug, first we conducted a qualitative study to explore what product attributes people consider when buying a weight-loss aid...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29703741/hyperpolarised-magnetic-resonance-for-in-vivo-real-time-metabolic-imaging
#10
REVIEW
Andrew Apps, Justin Lau, Mark Peterzan, Stefan Neubauer, Damian Tyler, Oliver Rider
Although non-invasive perfusion and viability imaging often provide the gateway to coronary revascularisation, current non-invasive imaging methods only report the surrogate markers of inducible hypoperfusion and presence or absence of myocardial scar, rather than actually visualising areas of ischaemia and/or viable myocardium. This may lead to suboptimal revascularisation decisions. Normally respiring (viable) cardiomyocytes convert pyruvate to acetyl-CoA and CO2 /bicarbonate (via pyruvate dehydrogenase), but under ischaemic conditions characteristically shift this conversion to lactate (by lactate dehydrogenase)...
April 27, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29674787/distinct-isotopic-signatures-reveal-effect-of-ecoregion-on-small-mammals-of-ghana
#11
Nyeema C Harris, Reuben A Garshong, Morgan Gray
Species reside in dynamic environments, simultaneously experiencing variations in climatic conditions, habitat availability and quality, interspecific interactions, and anthropogenic pressures. We investigated variation in foraging ecology of the small mammal community between land-use classifications (i.e., protected national parks and unprotected lands abutting them) in Mole National Park (MNP) and Digya National Park (DNP), representing distinct ecoregions of Ghana. In 5,064 trap nights, we sampled 153 individuals of 23 species within the 2 national parks and adjacent lands outside protected boundaries to describe variation in community composition...
February 1, 2018: Journal of Mammalogy
https://www.readbyqxmd.com/read/29674721/chitosan-titanium-oxide-fibers-supported-zero-valent-nanoparticles-highly-efficient-and-easily-retrievable-catalyst-for-the-removal-of-organic-pollutants
#12
Fayaz Ali, Sher Bahadar Khan, Tahseen Kamal, Khalid A Alamry, Abdullah M Asiri
Different chitosan-titanium oxide (CS-TiO2 -x, with x = TiO2 loadings of 1, 5, 10,15 and 20 wt%) nanocomposite fibers were prepared and kept separately in each salt solution of CuSO4 , CoNO3 , AgNO3 and NiSO4 to adsorb Cu2+ , Co2+ , Ag+ , and Ni+ ions, respectively. The metal ions loaded onto CS-TiO2 fibers were reduced to their respective zero-valent metal nanoparticles (ZV-MNPs) like Cu0 , Co0 , Ag0 and Ni0 by treating with NaBH4 . The CS-TiO2 fibers templated with various ZV-MNPs were characterized and investigated for their catalytic efficiency...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29672916/magic-angle-spinning-nmr-with-metallized-rotors-as-cylindrical-microwave-resonators
#13
Faith J Scott, Erika L Sesti, Eric J Choi, Alexander J Laut, Jagadishwar R Sirigiri, Alexander B Barnes
We introduce a novel design for millimeter wave electromagnetic structures within magic angle spinning (MAS) rotors. In this demonstration, a copper coating is vacuum deposited onto the outside surface of a sapphire rotor at a thickness of 50 nanometers. This thickness is sufficient to reflect 197 GHz microwaves, yet not too thick as to interfere with radiofrequency fields at 300 MHz or prevent sample spinning due to eddy currents. Electromagnetic simulations of an idealized rotor geometry show a microwave quality factor of 148...
April 19, 2018: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/29671848/a-luminescent-zinc-ii-coordination-polymer-with-unusual-3-4-4-coordinated-self-catenated-3d-network-for-selective-detection-of-nitroaromatics-and-ferric-and-chromate-ions-a-versatile-luminescent-sensor
#14
Ya-Qian Zhang, Vladislav A Blatov, Tian-Rui Zheng, Chang-Hao Yang, Lin-Lu Qian, Ke Li, Bao-Long Li, Bing Wu
A zinc(ii) coordination polymer {[Zn3(mtrb)3(btc)2]·3H2O}n (1) was synthesized and characterized (mtrb = 1,3-bis(1,2,4-triazole-4-ylmethyl)benzene, btc = 1,3,5-benzenetricarboxylate). The polymer 1 shows an unusual (3,4,4)-coordinated self-catenated 3D network with the point symbol of {63}2{62·82·102}{64·82}2. The polymer 1 is the first luminescent sensor for the detection of 2-amino-4-nitrophenol (ANP). The polymer 1 is also a good luminescence sensor for detection of TNP, 2,4-DNP, 4-NP, ANP and 2-NP in MeOH, particularly for TNP...
April 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29652146/dissolution-dynamic-nuclear-polarization-at-room-temperature-using-photoexcited-triplet-electrons
#15
Makoto Negoro, Akinori Kagawa, Kenichiro Tateishi, Yoshiki Tanaka, Tomohiro Yuasa, Keigo Takahashi, Masahiro Kitagawa
Dissolution dynamic nuclear polarization (DNP) has recently gained attention as a method to enhance the sensitivity of liquid NMR spectroscopy and MRI. Here, we demonstrate dissolution of the sample hyperpolarized by DNP using photoexcited triplet electrons in 0.38 T at room temperature. The achieved polarization of 0.8% is 6100 times as high as that at thermal equilibrium in the condition. The result is an important step for DNP using photoexcited triplet electrons to become widely used in chemical and biomedical research...
April 13, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29651884/kinetic-and-structural-studies-on-the-interactions-of-torpedo-californica-acetylcholinesterase-with-two-donepezil-like-rigid-analogues
#16
Rosanna Caliandro, Alessandro Pesaresi, Luca Cariati, Antonio Procopio, Manuela Oliverio, Doriano Lamba
Acetylcholinesterase inhibitors were introduced for the symptomatic treatment of Alzheimer's disease (AD). Among the currently approved inhibitors, donepezil (DNP) is one of the most preferred choices in AD therapy. The X-ray crystal structures of Torpedo californica AChE in complex with two novel rigid DNP-like analogs, compounds 1 and 2, have been determined. Kinetic studies indicated that compounds 1 and 2 show a mixed-type inhibition against TcAChE, with Ki values of 11.12 ± 2.88 and 29.86 ± 1...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29645035/electron-driven-spin-diffusion-supports-crossing-the-diffusion-barrier-in-mas-dnp
#17
Johannes J Wittmann, Michael Eckardt, Wolfgang Harneit, Björn Corzilius
Dynamic nuclear polarization (DNP) can be applied to enhance the sensitivity of solid-state NMR experiments by several orders of magnitude due to microwave-driven transfer of spin polarization from unpaired electrons to nuclei. While the underlying quantum mechanical aspects are sufficiently well understood on a microscopic level, the exact description of the large-scale spin dynamics, usually involving hundreds to thousands of nuclear spins per electron, is still lacking consensus. Generally, it is assumed that nuclear hyperpolarization can only be observed on nuclei which do not experience strong influence of the unpaired electrons and thus being significantly removed from the paramagnetic polarizing agents...
April 12, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29628771/activation-of-spinal-dorsal-horn-p2y-13-receptors-can-promote-the-expression-of-il-1%C3%AE-and-il-6-in-rats-with-diabetic-neuropathic-pain
#18
Rui Zhou, Tao Xu, XiaoHong Liu, YuanShou Chen, DeYing Kong, Hong Tian, Mingxia Yue, Dujuan Huang, Junwei Zeng
Objective: The dorsal horn P2Y13 receptor is involved in the development of pain behavior induced by peripheral nerve injury. It is unclear whether the expression of proinflammatory cytokines interleukin (IL)-1β and IL-6 at the spinal dorsal horn are influenced after the activation of P2Y13 receptor in rats with diabetic neuropathic pain (DNP). Methods: A rat model of type 1 DNP was induced by intraperitoneal injection of streptozotocin (STZ). We examined the expression of P2Y13 receptor, Iba-1, IL-1β, IL-6, JAK2, STAT3, pTyr1336 , and pTyr1472 NR2B in rat spinal dorsal horn...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29624056/measurement-of-kinetics-and-active-site-distances-in-metalloenzyme-using-paramagnetic-nmr-with-13-c-hyperpolarization
#19
Mengxiao Liu, Guannan Zhang, Nilkamal Mahanta, Youngbok Lee, Christian Hilty
Paramagnetic relaxation enhancement (PRE) conjoint with hyperpolarized NMR reveals structural information on the enzyme-product complex in an on-going metalloenzyme catalyzed reaction. Substrates of pseudouridine monophosphate glycosidase are hyperpolarized using the dynamic nuclear polarization (DNP) method. Time series of13 C NMR spectra are subsequently measured with the enzyme containing diamagnetic Mg2+ or paramagnetic Mn2+ ions in the active site. The differences of the signal evolution and line widths in the Mg2+ vs...
April 6, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29623738/erratum-to-acknowledgment-of-reviewers
#20
(no author information available yet)
Aponte, J. (2017): Acknowledgment of Reviewers. Hispanic Health Care International, 15, 200. Doi: 10.1177/1540415317746248 In the above "Acknowledgement of Reviewers", published in issue 15(4), nine reviewer names were not listed in the 'Acknowledgement to Reviewers' section. Please find below the names of the additional nine reviewers for 2017. The editor would also like to thank these reviewers for their participation and service to Hispanic Health Care International in 2017. María Luisa F. Arias, PhD, RN John Cowden, MD, MPH Giovanna De Oliveira, PhD, MSN, ARNP, ANP-C, PMHNP-BC Esther C...
March 2018: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
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