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Fragility Fracture

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https://www.readbyqxmd.com/read/29139194/advantages-of-care-for-patients-with-hip-fractures-in-the-acute-geriatric-unit-hip-study-anoia
#1
Enric Duaso, Francesc Formiga, Patrícia Marimón, Montserrat Sandiumenge, Maria Teresa Salgado, Victor Murga, Andrés Gamboa, Carlos Rodriguez, Jaume Castellà, Enrique Escalante, Célia Lumbreras, Anna Tarrida, Ramón Sellarès
AIM: Hip fracture as a result of bone fragility is characterized by poor health outcomes in the medium and long term. Our goal was to compare a new orthogeriatric model with the old trauma model and evaluate improvements in clinical management. METHODS: We carried out a comparative unicentric study, a historical sample (trauma model) collected from 1 June 2007 to 31 May 2010, versus a prospective sample (orthogeriatric model) collected from 1 June 2010 until 31 May 2013...
November 15, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29137106/trabecular-bone-score-as-a-supplementary-tool-for-the-discrimination-of-osteoporotic-fractures-in-postmenopausal-women-with-rheumatoid-arthritis
#2
Yong Jun Choi, Yoon-Sok Chung, Chang-Hee Suh, Ju-Yang Jung, Hyoun-Ah Kim
Rheumatoid arthritis (RA) is a risk factor for bone fragility, and its effect on fracture risk is independent of bone mineral density (BMD). The trabecular bone score (TBS) is a new indirect parameter of bone quality. In this study, BMD and the TBS were compared between female postmenopausal RA patients with and those without vertebral fractures (VFs).This study had a cross-sectional design. Two hundred seventy-nine postmenopausal women with RA aged 50 years or older were included in this study. TBS measurements were performed on the same vertebrae as those for the BMD measurements...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29134241/ct-based-evaluation-of-volumetric-bone-density-in-fragility-fractures-of-the-pelvis-a-matched-case-control-analysis
#3
D Schönenberg, R Guggenberger, D Frey, H-C Pape, H-P Simmen, G Osterhoff
This matched case-control study compared the computed tomography (CT)-based regional bone density of patients with fragility fractures of the sacrum to a control without fracture. Patients with a sacral fracture demonstrated a significantly lower regional bone density of the sacrum, the sacral bone density not being correlated with the BMD by DXA of the spine. INTRODUCTION: The aim of this study is to compare the computed tomography-based regional bone density measured by Hounsfield units (HUs) in patients with and without fragility fractures of the sacrum...
November 13, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29129436/effects-of-teriparatide-and-risedronate-on-new-fractures-in-post-menopausal-women-with-severe-osteoporosis-vero-a-multicentre-double-blind-double-dummy-randomised-controlled-trial
#4
David L Kendler, Fernando Marin, Cristiano A F Zerbini, Luis A Russo, Susan L Greenspan, Vit Zikan, Alicia Bagur, Jorge Malouf-Sierra, Péter Lakatos, Astrid Fahrleitner-Pammer, Eric Lespessailles, Salvatore Minisola, Jean Jacques Body, Piet Geusens, Rüdiger Möricke, Pedro López-Romero
BACKGROUND: No clinical trials have compared osteoporosis drugs with incident fractures as the primary outcome. We compared the anti-fracture efficacy of teriparatide with risedronate in patients with severe osteoporosis. METHODS: In this double-blind, double-dummy trial, we enrolled post-menopausal women with at least two moderate or one severe vertebral fracture and a bone mineral density T score of less than or equal to -1·50. Participants were randomly assigned to receive 20 μg of teriparatide once daily plus oral weekly placebo or 35 mg of oral risedronate once weekly plus daily injections of placebo for 24 months...
November 9, 2017: Lancet
https://www.readbyqxmd.com/read/29123427/effect-of-age-and-estrogen-on-biochemical-markers-of-bone-turnover-in-postmenopausal-women-a-population-based-study-from-nepal
#5
Bashu Dev Pardhe, Sabala Pathak, Anjeela Bhetwal, Sumitra Ghimire, Shreena Shakya, Puspa Raj Khanal, Sujan Babu Marahatta
Background: Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29122281/good-functional-outcome-in-patients-suffering-fragility-fractures-of-the-pelvis-treated-with-percutaneous-screw-stabilisation-assessment-of-complications-and-factors-influencing-failure
#6
Henrik Eckardt, Alexander Egger, Rebecca Maria Hasler, Christoph J Zech, Werner Vach, Norbert Suhm, Mario Morgenstern, Franziska Saxer
BACKGROUND: Low energy pelvic ring fractures in the elderly have traditionally been treated conservatively, a treatment with potential long-term complications and loss of self-independence. Percutaneous screw stabilisation of the posterior pelvic ring is a new treatment modality that enables immediate mobilisation. The aim of this study was to assess the functional outcome after sacroiliac stabilisation in the elderly. METHODS: All elderly patients with a surgically stabilised low energy pelvic fracture between 2010 and 2015 were included...
November 4, 2017: Injury
https://www.readbyqxmd.com/read/29121201/high-prevalence-of-radiological-vertebral-fractures-in-women-on-tsh-suppressive-therapy-for-thyroid-carcinoma
#7
Gherardo Mazziotti, Anna Maria Formenti, Stefano Frara, Roberto Olivetti, Giuseppe Banfi, Maurizio Memo, Roberto Maroldi, Raffaele Giubbini, Andrea Giustina
Context: Bone loss and non-vertebral fractures have been reported in patients with differentiated thyroid carcinoma (DTC) undergoing TSH-suppressive therapy. Radiological vertebral fractures (VFs) are an early and clinically crucial marker of bone fragility but they have never been investigated so far in this specific clinical setting. Objective and design: In this cross-sectional study we evaluated the prevalence and determinants of radiological VFs in women under L-T4 therapy for DTC...
November 7, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29116417/epidemiology-of-fractures-in-armenia-development-of-a-country-specific-frax-model-and-comparison-to-its-surrogate
#8
O Lesnyak, S Sahakyan, A Zakroyeva, J P Bilezikian, N Hutchings, V Babalyan, R Galstyan, A Lebedev, H Johansson, N C Harvey, E McCloskey, John A Kanis
Fracture probabilities derived from the surrogate FRAX model for Armenia were compared to those from the model based on regional estimates of the incidence of hip fracture. Disparities between the surrogate and authentic FRAX models indicate the importance of developing country-specific FRAX models. Despite large differences between models, differences in the rank order of fracture probabilities were minimal. OBJECTIVE: Armenia has relied on a surrogate FRAX model based on the fracture epidemiology of Romania...
November 7, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29115921/identifying-protective-and-risk-factors-for-injurious-falls-in-patients-hospitalized-for-acute-care-a-retrospective-case-control-study
#9
Emmanuel Aryee, Spencer L James, Guenola M Hunt, Hilary F Ryder
BACKGROUND: Admitted patients who fall and injure themselves during an acute hospitalization incur increased costs, morbidity, and mortality, but little research has been conducted on identifying inpatients at high risk to injure themselves in a fall. Falls risk assessment tools have been unsuccessful due to their low positive predictive value when applied broadly to entire hospital populations. We aimed to identify variables associated with the risk of or protection against injurious fall in the inpatient setting...
November 7, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29115684/bone-material-strength-index-as-measured-by-impact-microindentation-in-postmenopausal-women-with-distal-radius-and-hip-fractures
#10
Tamara D Rozental, Kempland C Walley, Serkalem Demissie, Signe Caksa, Adriana Martinez-Betancourt, Amber M Parker, Joy N Tsai, Elaine W Yu, Mary L Bouxsein
We tested whether cortical bone tissue properties assessed by in vivo impact microindentation would distinguish postmenopausal women with recent distal radius (DRF) or hip fracture (HF) from non-fracture controls (CONT). We enrolled postmenopausal women with recent DRF (n=57), HF (n=41) or CONT (n=93), and used impact microindentation to assess bone material strength index (BMSi) at the anterior surface of the mid-tibia diaphysis. Areal BMD (g/cm(2) ) of the femoral neck (FN), total hip (TH) and lumbar spine (LS) were measured by dual-energy X-ray absorptiometry (DXA)...
November 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29108851/examining-tissue-composition-whole-bone-morphology-and-mechanical-behavior-of-gorab-prx1-mice-tibiae-a-mouse-model-of-premature-aging
#11
Haisheng Yang, Laia Albiol, Wing-Lee Chan, Dag Wulsten, Anne Seliger, Michael Thelen, Tobias Thiele, Lyudmila Spevak, Adele Boskey, Uwe Kornak, Sara Checa, Bettina M Willie
Gerodermia osteodysplastica (GO) is a segmental progeroid disorder caused by loss-of-function mutations in the GORAB gene, associated with early onset osteoporosis and bone fragility. A conditional mouse model of GO (Gorab(Prx1)) was generated in which the Gorab gene was deleted in long bones. We examined the biomechanical/functional relevance of the Gorab(Prx1) mutants as a premature aging model by characterizing bone composition, tissue-level strains, and whole-bone morphology and mechanical properties of the tibia...
October 25, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29106756/biomechanical-investigation-of-four-different-fixation-techniques-in-sacrum-denis-type-ii-fracture-with-low-bone-mineral-density
#12
Yves P Acklin, Ivan Zderic, R Geoff Richards, Paul Schmitz, Boyko Gueorguiev, Stephan Grechenig
With increasing life expectancy, fragility fractures of the pelvic ring are seen more frequently. Although their osteosynthesis can be very challenging, specific biomechanical studies for investigation of the fixation stability are still lacking. The aim of this study was to biomechanically evaluate four different fixation methods for sacrum Denis type II fractures in osteoporotic bone. Unstable Denis type II vertical sacrum fractures were created in 16 human pelves. Their osteosynthesis was performed with one sacro-iliac screw, posterior sacral plating, triangular fixation, or spino-pelvic fixation...
November 6, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29106548/comprehensive-geriatric-assessment-for-identifying-older-people-at-risk-of-hip-fracture-cross-sectional-study-with-comparative-group
#13
Raquel Ramírez-Martín, María Victoria Castell Alcalá, Teresa Alarcón, Rocío Queipo, Peggy Paola Ríos Germán, Ángel Otero Puime, Juan Ignacio González-Montalvo
Background: Hip fracture (HF) is by far the most common serious fragility fracture. Its care is a major challenge to all healthcare systems. Aim: To determine whether there are characteristics of older people identified via comprehensive geriatric assessment (CGA) that help identify those with an increased risk of HF. Methods: The demographic, functional, cognitive and nutritional data of a cohort of patients admitted for acute HF were compared with those of a population cohort representing community-dwelling older people in the same urban district without HF...
July 4, 2017: Family Practice
https://www.readbyqxmd.com/read/29103097/vertebral-imaging-in-the-diagnosis-of-osteoporosis-a-clinician-s-perspective
#14
REVIEW
Sharon H Chou, Meryl S LeBoff
PURPOSE OF REVIEW: Vertebral fractures are the most common osteoporotic fracture and result in functional decline and excess mortality. Dual-energy x-ray absorptiometry (DXA) is the gold standard for the diagnosis of osteoporosis to identify patients at risk for fragility fractures; however, advances in imaging have expanded the role of computed tomography (CT) and magnetic resonance imaging (MRI) in evaluating bone health. RECENT FINDINGS: The utility of CT and MRI in the assessment of bone density is starting to gain traction, particularly when used opportunistically...
November 4, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29101659/bone-mechanical-function-and-the-gut-microbiota
#15
C J Hernandez
The primary function of bone in the body is to resist mechanical forces. Impairment of the mechanical performance of bone is therefore the primary clinical challenge presented by bone disease. Failure to resist forces associated with activities of daily living leads to fragility fracture. In this chapter we review the characteristics of bone that influence mechanical performance and fracture risk, how bone remodeling and modeling alter mechanically relevant characteristics of bone, and the potential for the gut microbiome to alter bone mechanical performance and risk of fragility fracture...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29084183/dietary-magnesium-may-be-protective-for-aging-of-bone-and-skeletal-muscle-in-middle-and-younger-older-age-men-and-women-cross-sectional-findings-from-the-uk-biobank-cohort
#16
Ailsa A Welch, Jane Skinner, Mary Hickson
Although fragility fractures, osteoporosis, sarcopenia, and frailty are becoming more prevalent in our aging society the treatment options are limited and preventative strategies are needed. Despite magnesium being integral to bone and muscle physiology, the relationship between dietary magnesium and skeletal muscle and bone health has not been investigated concurrently to date. We analysed cross-sectional associations between dietary magnesium and skeletal muscle mass (as fat free mass-FFM), grip strength, and bone density (BMD) in 156,575 men and women aged 39-72 years from the UK Biobank cohort...
October 30, 2017: Nutrients
https://www.readbyqxmd.com/read/29083977/examining-the-effect-of-medication-adherence-on-risk-of-subsequent-fracture-among-women-with-a-fragility-fracture-in-the-u-s-medicare-population
#17
Allison Keshishian, Natalie Boytsov, Russel Burge, Kelly Krohn, Louise Lombard, Xiang Zhang, Lin Xie, Onur Baser
BACKGROUND: In the United States, osteoporosis affects approximately 10 million people, of whom 80% are women, and it contributes a significant clinical burden to the community. Poor adherence to osteoporosis medications adds to the overall burden of illness. OBJECTIVE: To examine the association of osteoporosis medication adherence and the risk of a subsequent fracture among Medicare-enrolled women with a previous fragility fracture. METHODS: This study was a retrospective observational analysis of U...
November 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29083352/injuries-of-the-trochanteric-region-can-analysis-of-radiographic-indices-help-in-prediction-of-recurrent-osteoporotic-hip-fractures
#18
Andrea Pellegrini, Fabrizio Tacci, Massimiliano Leigheb, Cosimo Costantino, Alessio Pedrazzini, Giuseppe Pedrazzi, Enrico Vaienti, Francesco Ceccarelli, Francesco Pogliacomi
OBJECTIVE: In a context of bone fragility, primitive and subsequent fractures are a growing problem in the industrialized countries where the mean age of the population is constantly increasing. Among the various factors that favor a fragility fracture, the most important is osteoporosis, a pathology that can be prevented through diagnostic screenings and treated by pharmacological and rehabilitative therapies. The aim of this study is to identify the subjects who are likely to have a higher risk of subsequent fractures of the trochanteric region through a retrospective radiographic evaluation of patients affected by low-energy trochanteric fractures and operated by intramedullary fixation between June 2013 and June 2015, so they can be targeted for prevention interventions...
October 18, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29075333/the-impact-of-type-2-diabetes-on-bone-metabolism
#19
REVIEW
Claudia Pinheiro Sanches, Andre Gustavo Daher Vianna, Fellype de Carvalho Barreto
Diabetes complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients and share many features including genetic susceptibility, molecular mechanisms, and environmental factors. Type 2 diabetes mellitus (T2DM) compromises bone microarchitecture by inducing abnormal bone cell function and matrix structure, with increased osteoblast apoptosis, diminished osteoblast differentiation, and enhanced osteoclast-mediated bone resorption. The linkage between these two chronic diseases creates a possibility that certain antidiabetic therapies may affect bone quality...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29075114/a-bone-resorption-surface-targeting-nanoparticle-to-deliver-anti-mir214-for-osteoporosis-therapy
#20
Mingxiang Cai, Li Yang, Shufan Zhang, Jiafan Liu, Yao Sun, Xiaogang Wang
With increasing fracture risks due to fragility, osteoporosis is a global health problem threatening postmenopausal women. In these patients, osteoclasts play leading roles in bone loss and fracture. How to inhibit osteoclast activity is the key issue for osteoporosis treatment. In recent years, miRNA-based gene therapy through gene regulation has been considered a potential therapeutic method. However, in light of the side effects, the use of therapeutic miRNAs in osteoporosis treatment is still limited by the lack of tissue/cell-specific delivery systems...
2017: International Journal of Nanomedicine
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