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Fragility Fracture

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https://www.readbyqxmd.com/read/29354161/atypical-femur-fractures-a-distinctive-tract-of-adult-hypophosphatasia
#1
REVIEW
Francesca Marini, Maria Luisa Brandi
Hypophosphatasia (HPP) is a congenital, rare and heterogeneous bone disorder, characterized by a deficit of calcified tissue mineralization, leading to skeletal deformities and osteomalacia in adults, rickets in infants and children, and fragility fractures and premature loss of dentition in children and adults. The disease is caused by a reduced or absent expression and activity of the tissue non-specific alkaline phosphatase (TNSALP) enzyme, derived from inactivating mutations of the alkaline phosphatase (ALPL) gene...
September 2017: Clinical Cases in Mineral and Bone Metabolism
https://www.readbyqxmd.com/read/29353418/emerging-trends-in-hospitalisation-for-fragility-fractures-in-ireland
#2
M A Kelly, B McGowan, M J McKenna, K Bennett, J J Carey, B Whelan, C Silke
BACKGROUND: We analysed hospital admissions and bed occupancy for fragility fractures in Ireland over a 15-year period to assess fracture admission trends and to project admissions over the next three decades. METHODS: We used the Hospital In-Patient Enquiry (HIPE) scheme to extract data on fracture admissions to Irish hospitals between 2000 and 2014 inclusive. We calculated absolute numbers and age-standardised rates of hospitalisations for men and women ≥ 50 years for each osteoporotic-type fracture...
January 20, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29353316/validation-of-a-new-classification-for-periprosthetic-shoulder-fractures
#3
Chlodwig Kirchhoff, Marc Beirer, Ulrich Brunner, Arne Buchholz, Peter Biberthaler, Moritz Crönlein
INTRODUCTION: Successful treatment of periprosthetic shoulder fractures depends on the right strategy, starting with a well-structured classification of the fracture. Unfortunately, clinically relevant factors for treatment planning are missing in the pre-existing classifications. Therefore, the aim of the present study was to describe a new specific classification system for periprosthetic shoulder fractures including a structured treatment algorithm for this important fragility fracture issue...
January 20, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29350648/imaging-of-metabolic-bone-disease
#4
Maria Mattera, Alfonso Reginelli, Silvia Bartollino, Claudio Russo, Antonio Barile, Domenico Albano, Giovanni Mauri, Carmelo Messina, Salvatore Cappabianca, Giuseppe Guglielmi
Osteoporosis is the most important metabolic bone disease, with a wide distribution among the elderly. It is characterized by low bone mass and micro architectural deterioration of bone tissue, leading to enhanced bone fragility and a consequent increase in fracture risk. Identify bone weakening with an appropriate and accurate use of diagnostic imaging is of critical importance in the diagnosis and follow-up of osteoporotic patients. The aim of this review is to evaluate the detection rates of the different imaging modalities in the evaluation of bone strength, in the assessment of fracture risk and in the management of fragility fractures...
January 19, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29344812/short-term-and-long-term-effects-of-osteoporosis-on-incisor-teeth-and-femoral-bones-evaluated-by-raman-spectroscopy-and-energy-dispersive-x-ray-analysis-in-ovariectomized-rats
#5
Fernanda Rossi Paolillo, Renan Arnon Romano, Luciana de Matos, Airton Abrahão Martin, Francisco Eduardo Gontijo Guimarães, Jarbas Caiado de Castro Neto, Vanderlei Salvador Bagnato
There are few published data on the relationship between loss of bone mass due to osteoporosis and poor tooth quality. This study analyzed the effects of osteoporosis on incisor teeth and femoral bones using optical techniques in rats. Twenty female Wistar rats aged 6 months (n = 20) were randomized into two groups: control group, non-ovariectomized rats (n = 10); ovariectomy group, ovariectomized rats to induce osteoporosis (n = 10). Each group was subdivided randomly into two groups containing five rats each as follows...
January 17, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29344653/a-novel-variant-of-osteogenesis-imperfecta-type-iv-and-low-serum-phosphorus-level-caused-by-a-val94asp-mutation-in-col1a1
#6
Qi Yang, Hong Xu, Jinsi Luo, Qinle Zhang, Bobo Xie, Sheng Yi, Xiuliang Rong, Jin Wang, Zailong Qin, Tingting Jiang, Li Lin, Yangjin Zuo, Xin Fan
Osteogenesis imperfecta (OI) is a rare congenital disorder characterized by bone fragility and fractures, and associated with bone deformity, short stature, dentin, ligament and blue‑gray eye sclera. OI is caused by a heterozygous mutation in collagen α‑1(I) chain (COL1A1) or collagen α‑2(I) chain (COL1A2) genes that encode α chains of type I collagen. Collagen α chain peptide contains an N‑propeptide, which has a role in assembly and processing of collagen. Point mutations in the N‑propeptide domain appear to trigger OI...
January 16, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29342321/contributions-of-material-properties-and-structure-to-increased-bone-fragility-for-a-given-bone-mass-in-the-ucd-t2dm-rat-model-of-type-2-diabetes
#7
Claire Acevedo, Meghan Sylvia, Eric Schaible, James L Graham, Kimber L Stanhope, Lionel N Metz, Bernd Gludovatz, Ann V Schwartz, Robert O Ritchie, Tamara N Alliston, Peter J Havel, Aaron J Fields
Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we demonstrate that diabetes significantly reduces whole-bone strength for a given bone mass (micro-CT-derived BMC), and we quantify the roles of T2D-induced deficits in material properties versus bone structure, i.e., geometry and microarchitecture. Lumbar vertebrae and ulnae were harvested from 6-month-old lean Sprague-Dawley rats, obese Sprague-Dawley rats, and diabetic obese UCD-T2DM rats (diabetic for 69 ± 7 days; blood glucose >200 mg/dl)...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29340971/denosumab-or-oral-bisphosphonates-in-primary-osteoporosis-a-real-life-study
#8
E Cairoli, S Palmieri, G Goggi, L Roggero, M Arosio, I Chiodini, C Eller-Vainicher
PURPOSE: To compare the response to denosumab (DMAb) therapy with that of oral bisphosphonate (BISPH) treatment in postmenopausal women with primary osteoporosis (PO). METHODS: In this retrospective study, we compared data of 75 PO female patients treated for 24 months with DMab (DMAb Group, age 72.6 ± 8.9 years) with those of 75 PO patients treated with oral bisphosphonates (BISPH Group), matched for age, body mass index, femoral bone mineral density (BMD), prevalent fragility fractures and familiar history of hip fracture...
January 16, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29333578/insulin-resistance-and-bone-a-biological-partnership
#9
Caterina Conte, Solomon Epstein, Nicola Napoli
Despite a clear association between type 2 diabetes (T2D) and fracture risk, the pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is the primary defect in T2D. Insulin signalling regulates both bone formation and bone resorption, but whether insulin resistance can affect bone has not been established. On the other hand, evidence exists that bone might play a role in the regulation of glucose metabolism. This article reviews the available experimental and clinical evidence on the interplay between bone and insulin resistance...
January 15, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29329713/baseline-and-pre-operative-1-year-mortality-risk-factors-in-a-cohort-of-509-hip-fracture-patients-consecutively-admitted-to-a-co-managed-orthogeriatric-unit-fonda-cohort
#10
Rocío Menéndez-Colino, Teresa Alarcon, Pilar Gotor, Rocío Queipo, Raquel Ramírez-Martín, Angel Otero, Juan I González-Montalvo
INTRODUCTION: The aim of this study was to determine the patient characteristics that predict 1-year mortality after a hip fracture (HF). METHODS: All patients admitted consecutively with fragility HF during 1 year in a co-managed orthogeriatric unit of a university hospital (FONDA cohort) were assesed. Baseline and admission demographic, clinical, functional, analytical and body-composition variables were collected in the first 72 h after admission. A protocol designed to minimize the consequences of the HF was applied...
January 6, 2018: Injury
https://www.readbyqxmd.com/read/29329484/effects-of-teriparatide-compared-with-risedronate-on-the-risk-of-fractures-in-subgroups-of-postmenopausal-women-with-severe-osteoporosis-the-vero-trial
#11
Piet Geusens, Fernando Marin, David L Kendler, Luis A Russo, Cristiano A F Zerbini, Salvatore Minisola, Jean Jacques Body, Eric Lespessailles, Susan L Greenspan, Alicia Bagur, Jan J Stepan, Péter Lakatos, Enrique Casado, Rüdiger Moericke, Pedro López-Romero, Astrid Fahrleitner-Pammer
The 2-year, randomized, double-blind, active-controlled fracture endpoint VERO study included postmenopausal women with established osteoporosis, who had at least 2 moderate or 1 severe baseline vertebral fractures (VFx), and BMD T-score ≤-1.5. Patients were treated with either s.c. daily teriparatide 20 μg or oral weekly risedronate 35 mg. As previously reported, the risk of new VFx and clinical fractures (a composite of clinical VFx and non vertebral fragility fractures [NVFFx]) was statistically significantly reduced with teriparatide compared with risedronate...
January 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29322222/urinary-pentosidine-levels-negatively-associates-with-trabecular-bone-scores-in-patients-with-type-2-diabetes-mellitus
#12
Y J Choi, S Y Ock, Y Jin, J S Lee, S H Kim, Y -S Chung
Pentosidine levels were higher in diabetic patients with vertebral fractures. Trabecular bone scores were negatively associated with pentosidine levels in diabetic patients only. Our results provide further evidence that AGEs are associated with the pathogenesis of bone fragility in patients with T2DM. INTRODUCTION: Type 2 diabetes mellitus (T2DM) is associated with fracture risk. Pentosidine, an advanced glycation end product (AGE), is associated with prevalent vertebral fractures (VFs) in patients with T2DM...
January 10, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29318086/putting-the-brakes-on-breaks-osteoporosis-screening-and-fracture-prevention
#13
Sarah C Goode, Jacqueline L Beshears, Russell D Goode, Theresa F Wright, Anita King, Brett D Crist
Introduction: This prospective study sought to implement a screening tool to identify and risk stratify at-risk patients for osteoporosis and evaluate patient knowledge of osteoporosis and fragility fractures in an orthopedic trauma clinic affiliated with a level 1 trauma academic center. Methods: Of 297 eligible patients, 291 were screened and risk stratified. Patients completed an osteoporosis screening questionnaire and were risk stratified. Lifestyle advice was given to patients at low fracture risk...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29318083/a-missed-opportunity-in-bone-health-vitamin-d-and-calcium-use-in-elderly-femoral-neck-fracture-patients-following-arthroplasty
#14
Sheila Sprague, Kim Madden, Gerard Slobogean, Brad Petrisor, Jonathan D Rick Adachi, Earl Bogoch, Ydo V Kleinlugtenbelt, Mohit Bhandari
Introduction: Introduction: Adequate calcium and vitamin D from diet and supplementation is recommended for elderly hip fracture patients. Using data from the multinational hip fracture arthroplasty trial (HEALTH), we determined the proportion of patients who consistently took vitamin D and calcium and which characteristics/prescribing practices were associated with consistency of supplement use. Methods: HEALTH is a multicenter randomized trial of elderly hip fracture patients treated with hemi-arthroplasty and total hip arthroplasty...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29314659/effectiveness-of-using-a-new-polyurethane-foam-multi-layer-dressing-in-the-sacral-area-to-prevent-the-onset-of-pressure-ulcer-in-the-elderly-with-hip-fractures-a-pragmatic-randomised-controlled-trial
#15
Cristiana Forni, Fabio D'Alessandro, Pina Gallerani, Rossana Genco, Andrea Bolzon, Caterina Bombino, Sandra Mini, Laura Rocchegiani, Teresa Notarnicola, Arianna Vitulli, Alfredo Amodeo, Guglielmo Celli, Patrizia Taddia
Hip fractures in the elderly are a serious problem for the health service due to the high rate of complications. One of these complications is pressure ulcers that, according to the literature, occur in 8.8% to 55% of patients and mainly arise in the sacral area. The present randomised controlled trial tests whether applying a new innovative multi-layer polyurethane foam dressing (ALLEVYN LIFE™), reduces the onset of pressure ulcers in the sacral area. From March to December 2016, 359 fragility hip fracture patients were randomly divided into 2 groups: 182 in the control group and 177 in the experimental group...
January 4, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29314261/future-osteoporotic-fracture-risk-related-to-lumbar-vertebral-trabecular-attenuation-measured-at-routine-body-ct
#16
Scott J Lee, Peter M Graffy, Ryan D Zea, Timothy J Ziemlewicz, Perry J Pickhardt
We sought to determine if vertebral trabecular attenuation values measured on routine body CT scans obtained for a variety of unrelated indications can predict future osteoporotic fractures at multiple skeletal sites. For this HIPAA-compliant and IRB-approved retrospective cohort study, trabecular attenuation of the first lumbar vertebra was measured in 1966 consecutive older adults who underwent chest and/or abdominal CT at a single institution over the course of one year. New pathologic fragility fractures that occurred after a patient's CT study date were identified through an electronic health record database query using ICD-9 codes for vertebral, hip, and extremity fractures...
January 3, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29313169/upright-activity-and-higher-motor-function-may-preserve-bone-mineral-density-within-6%C3%A2-months-of-stroke-a-longitudinal-study
#17
Karen Borschmann, Sandra Iuliano, Ali Ghasem-Zadeh, Leonid Churilov, Marco Y C Pang, Julie Bernhardt
PURPOSE: Bone fragility contributes to increased fracture risk, but little is known about the emergence of post-stroke bone loss. We investigated skeletal changes and relationships with physical activity, stroke severity, motor control and lean mass within 6 months of stroke. METHODS: This is a prospective observational study. Participants were non-diabetic but unable to walk within 2 weeks of first stroke. Distal tibial volumetric bone mineral density (vBMD, primary outcome), bone geometry and microstructure (high-resolution peripheral quantitative computed tomography) were assessed at baseline and 6 months, as were secondary outcomes total body bone mineral content and lean mass (dual energy X-ray absorptiometry), bone metabolism (serum osteocalcin, N-terminal propeptide of type 1 procollagen (P1NP), C-terminal telopeptide of type 1 collagen (CTX)), physical activity (PAL2 accelerometer) and motor control (Chedoke McMaster) which were also measured at 1 and 3 months...
January 8, 2018: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29310418/improvements-in-osteoporosis-testing-and-care-are-found-following-the-wide-scale-implementation-of-the-ontario-fracture-clinic-screening-program-an-interrupted-time-series-analysis
#18
Dorcas E Beaton, Muhammad Mamdani, Hong Zheng, Susan Jaglal, Suzanne M Cadarette, Earl R Bogoch, Joanna E M Sale, Rebeka Sujic, Ravi Jain
We evaluated a system-wide impact of a health intervention to improve treatment of osteoporosis after a fragility fracture. The intervention consisted of assigning a screening coordinator to selected fracture clinics to identify, educate, and follow up with fragility fracture patients and inform their physicians of the need to evaluate bone health. Thirty-seven hospitals in the province of Ontario (Canada) were assigned a screening coordinator. Twenty-three similar hospitals were control sites. All hospitals had orthopedic services and handled moderate-to-higher volumes of fracture patients...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305651/-management-of-osteoporosis-after-fragility-fractures
#19
M Gosch, U Stumpf, C Kammerlander, W Böcker, H J Heppner, S Wicklein
Osteoporosis is defined as a systemic bone disease with decreased bone strength and an increased susceptibility for fractures. Older people in particular face an increased risk of fractures. These kind of fractures are usually caused by an inadequate trauma and are the so-called fragility fractures. In older adults immediate fracture stabilization and early mobilization have become the standard procedure after a fragility fracture. Treatment of the underlying osteoporosis often plays a minor role in clinical practice...
January 5, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29304151/the-role-of-carboxy-terminal-cross-linking-telopeptide-of-type-i-collagen-dual-x-ray-absorptiometry-bone-strain-and-romberg-test-in-a-new-osteoporotic-fracture-risk-evaluation-a-proposal-from-an-observational-study
#20
Fabio M Ulivieri, Luca P Piodi, Enzo Grossi, Luca Rinaudo, Carmelo Messina, Anna P Tassi, Marcello Filopanti, Anna Tirelli, Francesco Sardanelli
The consolidated way of diagnosing and treating osteoporosis in order to prevent fragility fractures has recently been questioned by some papers, which complained of overdiagnosis and consequent overtreatment of this pathology with underestimating other causes of the fragility fractures, like falls. A new clinical approach is proposed for identifying the subgroup of patients prone to fragility fractures. This retrospective observational study was conducted from January to June 2015 at the Nuclear Medicine-Bone Metabolic Unit of the of the Fondazione IRCCS Ca' Granda, Milan, Italy...
2018: PloS One
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