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REVIEW
Yu He, Jiaxi Lin, Shiqi Zhu, Jinzhou Zhu, Zhonghua Xu
OBJECTIVE: Osteoporosis is a systemic bone disease characterized by low bone mass, damaged bone microstructure, increased bone fragility, and susceptibility to fractures. With the rapid development of artificial intelligence, a series of studies have reported deep learning applications in the screening and diagnosis of osteoporosis. The aim of this review was to summary the application of deep learning methods in the radiologic diagnosis of osteoporosis. METHODS: We conducted a two-step literature search using the PubMed and Web of Science databases...
April 2024: Journal of International Medical Research
#2
JOURNAL ARTICLE
Carmelinda Ruggiero, Ilaria Giovanna Macchione, Valentina Gemo, Chiara Properzi, Federica Perini, Annarita Bianco, Maria Cristina Ercolani, Marco Mencacci, Pietro Manzi, Arturo Pasqualucci, Giuseppe De Filippis, Marta Baroni, Patrizia Mecocci
Background: Telemedicine has increasingly widespread to improve the monitoring of patients with chronic diseases. Secondary prevention of fragility fractures is an urgent matter to be addressed by means of available technology, although supported by little evidence so far. We investigated the feasibility, efficacy, and satisfaction of managing older adults at high risk of fragility fractures during the COVID-19 lockdown. Methods: During the period January to July 2021, a prospective observational study for safety and adherence purposes was conducted among older adults (n = 407) with ongoing treatments for secondary prevention of fragility fractures...
April 24, 2024: Telemedicine Journal and E-health
#3
REVIEW
Michael T Stoddart, Georgios N Panagopoulos, Richard S Craig, Mark Falworth, David Butt, Will Rudge, Deborah Higgs, Addie Majed
BACKGROUND: Fractures of the distal humerus are a common fragility fracture in older adults. The purpose of this study was to systematically review the literature to produce pooled estimates of the outcomes of treatment using total elbow arthroplasty (TEA), open reduction and locking plate fixation (ORIF), hemiarthroplasty or with conservative management. METHODS: A systematic review of PUBMED and EMBASE databases was conducted for studies reporting outcomes of intra-articular fractures in older adults...
April 2024: Shoulder & Elbow
#4
JOURNAL ARTICLE
Angelo Fassio, Davide Gatti, Annalisa Biffi, Raffaella Ronco, Gloria Porcu, Giovanni Adami, Rosaria Alvaro, Riccardo Bogini, Achille P Caputi, Luisella Cianferotti, Bruno Frediani, Stefano Gonnelli, Giovanni Iolascon, Andrea Lenzi, Salvatore Leone, Raffaella Michieli, Silvia Migliaccio, Tiziana Nicoletti, Marco Paoletta, Annalisa Pennini, Eleonora Piccirilli, Maurizio Rossini, Maria Luisa Brandi, Giovanni Corrao, Umberto Tarantino
BACKGROUND: Subjects with a fragility fracture have an increased risk of a new fracture and should receive effective strategies to prevent new events. The medium-term to long-term strategy should be scheduled by considering the mechanisms of action in therapy and the estimated fracture risk. OBJECTIVE: A systematic review was conducted to evaluate the sequential strategy in patients with or at risk of a fragility fracture in the context of the development of the Italian Guidelines...
2024: Therapeutic Advances in Musculoskeletal Disease
#5
JOURNAL ARTICLE
Kyoko Kasahara, Sachiko Tanaka-Mizuno, Shunichiro Tsuji, Mizuki Ohashi, Makiko Kasahara, Taku Kawasaki, Takashi Murakami
BACKGROUND: Pregnancy and lactation-associated osteoporosis (PLO), as well as premenopausal osteoporosis, might be a predictor of future fracture. This study aimed to describe the clinical features of PLO as a subtype of premenopausal osteoporosis and to evaluate medical interventions for it. METHODS: From an administrative claims database including 4,224,246 people in Japan, we classified women for whom the date of childbirth had been defined and who had suffered low-trauma fracture between the ages of 18-47 years as the premenopausal osteoporosis group...
April 22, 2024: BMC Pregnancy and Childbirth
#6
REVIEW
Alessandro Prete, Irina Bancos
The majority of incidentally discovered adrenal tumours are benign adrenocortical adenomas and the prevalence of adrenocortical adenomas is around 1-7% on cross-sectional abdominal imaging. These can be non-functioning adrenal tumours or they can be associated with autonomous cortisol secretion on a spectrum that ranges from rare clinically overt adrenal Cushing syndrome to the much more prevalent mild autonomous cortisol secretion (MACS) without signs of Cushing syndrome. MACS is diagnosed (based on an abnormal overnight dexamethasone suppression test) in 20-50% of patients with adrenal adenomas...
April 22, 2024: Nature Reviews. Endocrinology
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JOURNAL ARTICLE
Mark Haft, Sanjay Kubsad, John M Pirtle, Amil R Agarwal, Rachel Ranson, Thomas Fraychineaud, James DeBritz, Savyasachi C Thakkar, Gregory J Golladay
INTRODUCTION: Oral corticosteroids are the primary treatment for several autoimmune conditions. The risk of long-term implant, bone health, and infectious-related complications in patients taking chronic oral corticosteroids before total knee arthroplasty (TKA) is unknown. We compared the 10-year cumulative incidence of revision, periprosthetic joint infection (PJI), fragility fracture (FF), and periprosthetic fracture (PPF) following TKA in patients who had and did not have preoperative chronic oral corticosteroid use...
April 20, 2024: Journal of Arthroplasty
#8
JOURNAL ARTICLE
Fan Wang, Hui Li, Kaijun Yi, Yan Wu, Qingtao Bian, Baoyan Guo, Xingguang Luo, Yimin Kang, Qi Wu, Qinghe Ma
RATIONALE: Patients with schizophrenia with second-generation antipsychotics (SGAs) treatment have shown an increased risk of bone fragility and susceptibility to fracture; however, it is still unclear whether this risk is derived from the effect of antipsychotics on balance of bone metabolism. OBJECTIVES: We investigated the changes of two bone turnover biomarkers (BTMs) concentrations in people with schizophrenia receiving SGAs: procollagen type I aminoterminal propeptide (PINP) and C-terminal telopeptide of type I collagen (CTX-1) as BTMs of osteogenesis and bone resorption, respectively, to explore how antipsychotics contribute to bone fragility...
April 22, 2024: Psychopharmacology
#9
JOURNAL ARTICLE
Kei Sakamoto, Osamu Miyazaki, Ayako Imai, Reiko Okamoto, Yoshiyuki Tsutsumi, Mikiko Miyasaka, Atsuhito Seki, Takako Yoshioka, Shunsuke Nosaka
Osteoid osteoma (OO) is a common, benign bone tumor. However, there are no case reports of OO associated with osteogenesis imperfecta (OI), or pathological fractures in OO. A 3-year-old girl with OI sustained a complete right tibial diaphyseal fracture. Bony fusion was completed after 4 months of conservative therapy; nevertheless, 18 months later spontaneous pain appeared at the fracture site, without any cause. Plain radiographs showed a newly apparent, rounded area of translucency 1 cm in diameter, just overlapping the previous fracture...
April 22, 2024: Skeletal Radiology
#10
JOURNAL ARTICLE
Lamia Aldhbiban, Fai Alhoshan, Raghad Alomari, Shahad A Almatrafi, Yousef Alanazi, Samir Alsayegh, Haifa Y Alfaraidi, Ayman H Jawadi, Fahad N Aljuraibah
BACKGROUND: Children's bones are at high risk of fracture as they grow. The clinical characteristics of fractures in children differ from those in adults. Studying fractures in healthy children is critical for identifying cases of fragility fractures. The aim of this study was to assess the clinical characteristics of limb fractures as well as clinical indicators of fracture healing outcomes in healthy Saudi children seen in an emergency room. METHODS: A retrospective review of the treatment course of all pediatric fractures and related factors treated at King Abdullah Specialist Children's Hospital (KASCH) in Riyadh between 2016 and 2018 was conducted...
March 2024: Curēus
#11
Fabio Vescini, Giorgio Borretta, Iacopo Chiodini, Marco Boniardi, Marina Carotti, Elena Castellano, Cristiana Cipriani, Cristina Eller-Vainicher, Sandro Giannini, Maurizio Iacobone, Antonio Stefano Salcuni, Federica Saponaro, Stefano Spiezia, Annibale Versari, Guido Zavatta, Zuzana Mitrova, Rosella Saulle, Simona Vecchi, Debora Antonini, Michele Basile, Alexia Giovanazzi, Agostino Paoletta, Enrico Papini, Agnese Persichetti, Irene Samperi, Alessandro Scoppola, Roberto Novizio, Pietro Giorgio Calò, Filomena Cetani, Luisella Cianferotti, Sabrina Corbetta, Maria Luisa De Rimini, Alberto Falchetti, Giovanni Iannetti, Stefano Laureti, Celestino Pio Lombardi, Bruno Madeo, Claudio Marcocci, Sandro Mazzaferro, Vittorio Miele, Salvatore Minisola, Andrea Palermo, Jessica Pepe, Alfredo Scillitani, Laura Tonzar, Franco Grimaldi, Renato Cozzi, Roberto Attanasio
AIM: This guideline (GL) is aimed at providing a clinical practice reference for the management of sporadic primary hyperparathyroidism (PHPT) in adults. PHPT management in pregnancy was not considered. METHODS: This GL has been developed following the methods described in the Manual of the Italian National Guideline System. For each question, the panel appointed by Associazione Medici Endocrinology (AME) and Società Italiana dell'Osteoporosi, del Metabolismo Minerale e delle Malattie dello Scheletro (SIOMMMS) identified potentially relevant outcomes, which were then rated for their impact on therapeutic choices...
December 23, 2023: Endocrine, Metabolic & Immune Disorders Drug Targets
#12
JOURNAL ARTICLE
Ana Isabel Hormigo-Sánchez, Marta Neira-Álvarez, Teresa Pareja-Sierra
Osteoporosis is a metabolic and systemic disease characterized by alterations at the level of bone tissue with loss of bone mineral density, changes in microarchitecture, mineralization and remodeling that determine greater bone fragility and risk of fracture. Falls in the elderly are a risk factor closely related to fragility fractures and numerous studies demonstrate this relationship. Vertebral fractures are a major cause of morbidity and mortality. The epidemiology differs from osteoporotic fractures at other skeletal sites, as only one-third are clinically recognized...
April 18, 2024: Revista Española de Cirugía Ortopédica y Traumatología
#13
JOURNAL ARTICLE
P Checa-Betegón, R Luque-Pérez, D Oñate Martínez-Olascoaga, J L Pérez-González, I Domínguez-Esteban
Osteoporosis, and the consequences derived from it, such as fragility fractures, constitute a growing public health problem. Suffering from a fracture of this nature is the main risk factor for suffering a new fracture. It is documented that vertebral compression fractures lead to significant morbidity and mortality, in the short and long term, as well as other complications, such as sagittal imbalance and hyperkyphosis of the segment. However, we have not found documentation that analyzes the medium and long-term consequences of these injuries, assessing the type of treatment used, and the economic impact they represent...
April 18, 2024: Revista Española de Cirugía Ortopédica y Traumatología
#14
JOURNAL ARTICLE
Sansin Tuzun, Ulku Akarirmak, Bilal Kulaksiz, Aslinur Keles, Dilara Okutan, Pinar Karsli, Sevgi Selin Kurtoglu, Eren Aygun, Deniz Palamar
UNLABELLED: Although FRAX is used for fracture risk evaluation, this tool does not include balance and fall risk. The association between the predictors of falls and high FRAX scores we found in this study suggests that risk indicators for falls may add substantial value to FRAX by improving fracture risk prediction. PURPOSE: This observational, descriptive, and cross-sectional study aimed to assess the fall risk predictors and explore their association with FRAX in Turkish patients with postmenopausal osteoporosis...
April 20, 2024: Archives of Osteoporosis
#15
JOURNAL ARTICLE
Dalia Ali, Meshail Okla, Sarah Abuelreich, Radhakrishnan Vishnubalaji, Nicholas Ditzel, Rimi Hamam, Justyna M Kowal, Ahmed Sayed, Abdullah Aldahmash, Nehad M Alajez, Moustapha Kassem
INTRODUCTION: Osteoporosis is a systemic age-related disease characterized by reduced bone mass and microstructure deterioration, leading to increased risk of bone fragility fractures. Osteoporosis is a worldwide major health care problem and there is a need for preventive approaches. METHODS AND RESULTS: Apigenin and Rutaecarpine are plant-derived antioxidants identified through functional screen of a natural product library (143 compounds) as enhancers of osteoblastic differentiation of human bone marrow stromal stem cells (hBMSCs)...
2024: Frontiers in Endocrinology
#16
JOURNAL ARTICLE
T W Walshaw, T M Morris, M Fouweather, T E Baldock, N Wei, W G P Eardley
INTRODUCTION: The age of those experiencing traumatic injury and requiring surgery increases. The majority of this increase seen in older patients having operations after accidents is in fragility proximal femur fractures (FPFF). This study designed a model to predict the distribution of fractures suitable for ambulatory trauma list provision based on the number of FPFF patients. METHODS: The study utilized two datasets which both had data from 64 hospitals. One derived from the ORTHOPOD study dataset, and the other from National Hip Fracture Database...
April 3, 2024: Injury
#17
JOURNAL ARTICLE
Opinder Sahota, Melanie Narayanasamy, Anastasios Bastounis, Zoe Paskins, Simon Bishop, Tessa Langley, Neil Gittoes, Sarah Davis, Ann Baily, Moira Holmes, Jo Leonardi-Bee
BACKGROUND: Bisphosphonates are a class of medication commonly used to treat osteoporosis. Alendronate is recommended as the first-line treatment; however, long-term adherence (both treatment compliance and persistence) is poor. Alternative bisphosphonates are available, which can be given intravenously and have been shown to improve long-term adherence. However, the most clinically effective and cost-effective alternative bisphosphonate regimen remains unclear. What is the most cost-effective bisphosphonate in clinical trials may not be the most cost-effective or acceptable to patients in everyday clinical practice...
April 2024: Health Technology Assessment: HTA
#18
JOURNAL ARTICLE
Friederike Klauke
PURPOSE: Pathogenesis of sacral fragility fractures is not fully understood. This study investigates zonal distribution of calcium salt and fat marrow in intact bone-healthy and osteoporotic pelvis. In addition, in unilateral sacral fractures, the fracture side was compared with the intact side. METHODS: CT and MRI images of 37 pelves were analyzed. Zonal calcium salt distribution by Hounsfield units (HU) was recorded for each CT dataset. Fat marrow content was measured in MRI mDixon-Quant sequence...
April 17, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
#19
REVIEW
Gang Cao, ShaoQi Hu, Yan Ning, Xinyue Dou, Chuan Ding, Lu Wang, Zeping Wang, Xianan Sang, Qiao Yang, Jiangnan Shi, Min Hao, Xin Han
Osteoporosis characterized by decreased bone density and mass, is a systemic bone disease with the destruction of microstructure and increase in fragility. Osteoporosis is attributed to multiple causes, including aging, inflammation, diabetes mellitus, and other factors induced by the adverse effects of medications. Without treatment, osteoporosis will further progress and bring great trouble to human life. Due to the various causes, the treatment of osteoporosis is mainly aimed at improving bone metabolism, inhibiting bone resorption, and promoting bone formation...
2024: Frontiers in Pharmacology
#20
JOURNAL ARTICLE
Andrea Piazzolla, Davide Bizzoca, Giovanni Barbanti-Brodano, Matteo Formica, Luca Pietrogrande, Umberto Tarantino, Stefania Setti, Biagio Moretti, Giuseppe Solarino
BACKGROUND: Capacitively coupling electric fields (CCEF) is a method of non-invasive biophysical stimulation that enhances fracture repair and spinal fusion. This multicentre randomized controlled trial aimed to further examine the roles of CCEF in (1) the resolution of vertebral bone marrow oedema (VBME) using a follow-up MRI study and (2) pain relief, analgesic drug consumption and quality of life improvement in stimulated patients who were referred with acute vertebral fragility fractures (VFFs) compared to non-stimulated patients...
April 15, 2024: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
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