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John E Schiel, Abby Turner, Trina Mouchahoir, Katharina Yandrofski, Srivalli Telikepalli, Jason King, Paul DeRose, Dean Ripple, Karen Phinney
The NISTmAb Reference Material (RM) 8671 is intended to be an industry standard monoclonal antibody for pre-competitive harmonization of best practices and designing next generation characterization technologies for identity, quality, and stability testing. It must therefore embody the quality and characteristics of a typical biopharmaceutical product and be available long-term in a stable format with consistent product quality attributes. A stratified sampling and analysis plan using a series of qualified analytical and biophysical methods is described that assures RM 8671 meets these criteria...
February 7, 2018: Analytical and Bioanalytical Chemistry
Bing Han, Deborah A Cohen, Kathryn P Derose, Jiang Li, Stephanie Williamson
INTRODUCTION: Crime and safety are often cited as potential hurdles to park use and park-based physical activity. Using comprehensive data sources including both objective and subjective measurements at the park level and the individual level, this study aimed to assess the association between crime rates and use of local parks in low-income urban neighborhoods. METHODS: The authors observed 48 parks and conducted local resident surveys in low-income neighborhoods in Los Angeles during a 2-year study period (2013-2015)...
January 12, 2018: American Journal of Preventive Medicine
Barbara S deRose
INTRODUCTION: Alarming increases in childhood disease outbreaks present particular threats to children of immigrants in the United States. The researcher explores issues Latino immigrants experience when vaccinating their children in U.S. health care system. METHODOLOGY: A purposive sample of 11 Latino immigrants who sought immunizations for their foreign-born children during their first 5 years in the United States was obtained. Interview questions, probes, and data collection methods were based on interpretive phenomenology...
September 1, 2017: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
Luc Dubois, Britney Allen, Krista Bray-Jenkyn, Adam H Power, Guy DeRose, Thomas L Forbes, Audra Duncan, Salimah Z Shariff
OBJECTIVE: Volume-outcome relationships for open abdominal aortic aneurysm (AAA) repair have received less attention in publicly funded health systems. Furthermore, the roles of surgeon seniority (years of experience) and composite volume (encompassing all major arterial cases) on outcomes after open AAA repair are less well known. We sought to determine the effects of surgeon volume, surgeon years of experience, and composite volume on outcomes after elective open AAA repairs performed in Ontario, Canada...
December 13, 2017: Journal of Vascular Surgery
Kathryn P Derose, Bing Han, Stephanie Williamson, Deborah A Cohen
INTRODUCTION: Physical inactivity is more prevalent among women than men and is related to poor health outcomes. Neighborhood parks constitute an important resource for physical activity (PA), however, previous studies of park users have found fewer women being physically active. METHODS: We conducted a hierarchical mixed-effect regression analysis of the independent associations between gender and park use and PA among a population-based sample in high-poverty neighborhoods in Los Angeles...
December 11, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
Qi Sun, Jacqueline Lesperance, Hiromi Wettersten, Elaine Luterstein, Yoko S DeRose, Alana Welm, David A Cheresh, Jay S Desgrosellier
Breast cancer cells with stem cell properties are key contributors to metastatic disease, and there remains a need to better understand and target these cells in human cancers. Here, we identified rare stem-like cells in patients' tumors characterized by low levels of the proapoptotic molecule p53-upregulated modulator of apoptosis (PUMA) and showed that these cells play a critical role in tumor progression that is independent of clinical subtype. A signaling axis consisting of the integrin αvβ3, Src kinase, and the transcription factor Slug suppresses PUMA in these cells, promoting tumor stemness...
January 2, 2018: Journal of Clinical Investigation
Hideki Nakamura, Albert A Lee, Ali Sobhi Afshar, Shigeki Watanabe, Elmer Rho, Shiva Razavi, Allister Suarez, Yu-Chun Lin, Makoto Tanigawa, Brian Huang, Robert DeRose, Diana Bobb, William Hong, Sandra B Gabelli, John Goutsias, Takanari Inoue
Some protein components of intracellular non-membrane-bound entities, such as RNA granules, are known to form hydrogels in vitro. The physico-chemical properties and functional role of these intracellular hydrogels are difficult to study, primarily due to technical challenges in probing these materials in situ. Here, we present iPOLYMER, a strategy for a rapid induction of protein-based hydrogels inside living cells that explores the chemically inducible dimerization paradigm. Biochemical and biophysical characterizations aided by computational modelling show that the polymer network formed in the cytosol resembles a physiological hydrogel-like entity that acts as a size-dependent molecular sieve...
January 2018: Nature Materials
Muna T Canales, Erika W Hagen, Jodi H Barnet, Paul E Peppard, Stephen F Derose
Objective: To determine whether sleep apnea, defined by polysomnography, accelerates kidney function decline in generally healthy adults not selected for sleep apnea or kidney disease. Methods: We performed a retrospective cohort study 855 participants from the Wisconsin Sleep Cohort Study (WSCS), a large 20-year population-based study of sleep apnea, who had at least one polysomnogram and serial measurements of serum creatinine over time. Sleep apnea was defined as an apnea-hypopnea index ≥15 or positive airway pressure (PAP) use at baseline...
November 3, 2017: Sleep
Kory Plakos, Victoria J DeRose
Methods to map small-molecule binding sites on cellular RNAs are important for understanding interactions with both endogenous and exogenous compounds. Pt(ii) reagents are well-known DNA and RNA crosslinking agents, but sequence-specific and genome-wide identification of Pt targets following in-cell treatment is challenging. Here we describe application of high-throughput 'Pt-Seq' to identify Pt-rRNA adducts following treatment of S. cerevisiae with cisplatin.
November 28, 2017: Chemical Communications: Chem Comm
Kyungmin Kim, Lars C Pedersen, Thomas W Kirby, Eugene F DeRose, Robert E London
Aprataxin and PNKP-like factor (APLF) is a DNA repair factor containing a forkhead-associated (FHA) domain that supports binding to the phosphorylated FHA domain binding motifs (FBMs) in XRCC1 and XRCC4. We have characterized the interaction of the APLF FHA domain with phosphorylated XRCC1 peptides using crystallographic, NMR, and fluorescence polarization studies. The FHA-FBM interactions exhibit significant pH dependence in the physiological range as a consequence of the atypically high pK values of the phosphoserine and phosphothreonine residues and the preference for a dianionic charge state of FHA-bound pThr...
December 1, 2017: Nucleic Acids Research
Denise D Payán, Karen R Flórez, Laura M Bogart, David E Kanouse, Michael A Mata, Clyde W Oden, Kathryn P Derose
Embedding health messages into sermons is a potentially valuable strategy to address HIV and other health disparities in churches that predominantly serve racial and ethnic minorities. This study explores implementation of an HIV sermon as part of a multi-component intervention in three churches (Latino Catholic, Latino Pentecostal, and African American Baptist) in high HIV prevalence areas of Los Angeles County, California. Clergy were given an HIV sermon guide that included local public health data, stigma reduction cues, HIV testing messages, and a sample sermon...
October 20, 2017: Health Communication
Soha Namnabat, Kyung-Jo Kim, Adam Jones, Roland Himmelhuber, Christopher T DeRose, Douglas C Trotter, Andrew L Starbuck, Andrew Pomerene, Anthony L Lentine, Robert A Norwood
Silicon photonics has gained interest for its potential to provide higher efficiency, bandwidth and reduced power consumption compared to electrical interconnects in datacenters and high performance computing environments. However, it is well known that silicon photonic devices suffer from temperature fluctuations due to silicon's high thermo-optic coefficient and therefore, temperature control in many applications is required. Here we present an athermal optical add-drop multiplexer fabricated from ring resonators...
September 4, 2017: Optics Express
Deborah A Cohen, Kathryn Pitkin Derose, Bing Han, Stephanie Williamson, Terry Marsh, Laura Raaen
This study summarizes more than a decade of research on how well neighborhood parks in Los Angeles support physical activity. Between 2003 and 2015, researchers at the RAND Corporation studied 83 parks in the city of Los Angeles, conducting thousands of observations and fielding nearly 28,000 surveys of park users and local residents. About half of all residents said that they used their neighborhood parks, most of them routinely. Parks are also the top venue that people choose for engaging in routine exercise...
January 2017: Rand Health Quarterly
Eunice C Wong, Brad R Fulton, Kathryn P Derose
OBJECTIVE: This study assessed the prevalence of and factors associated with congregation-based programming in support of people with mental illness. METHODS: To estimate the proportion of congregations that provide mental health programming, this study reports analyses of survey responses from the 2012 National Congregations Study, a nationally representative survey of religious congregations in the United States (N=1,327). The analysis used multivariate logistic regression to identify congregational characteristics associated with the provision of mental health programming...
February 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
Rachael M Cunningham, Victoria J DeRose
Pt(II)-based anticancer drugs are widely used in the treatment of a variety of cancers, but their clinical efficacy is hindered by undesirable side effects and resistance. While much research has focused on Pt(II) drug interactions with DNA, there is increasing interest in proteins as alternative targets and contributors to cytotoxic and resistance mechanisms. Here, we describe a chemical proteomic method for isolation and identification of cellular protein targets of platinum compounds using Pt(II) reagents that have been modified for participation in the 1,3 dipolar cycloaddition "click" reaction...
November 17, 2017: ACS Chemical Biology
Kevin Lee, Patrick B Murphy, Matthew V Ingves, Audra Duncan, Guy DeRose, Luc Dubois, Thomas L Forbes, Adam Power
OBJECTIVE: The surgical site infection (SSI) rate in vascular surgery after groin incision for lower extremity revascularization can lead to significant morbidity and mortality. This trial was designed to study the effect of negative pressure wound therapy (NPWT) on SSI in closed groin wounds after lower extremity revascularization in patients at high risk for SSI. METHODS: A single-center, randomized, controlled trial was performed at an academic tertiary medical center...
August 30, 2017: Journal of Vascular Surgery
Dennis Hwang, Jeremiah W Chang, Adam V Benjafield, Maureen E Crocker, Colleen Kelly, Kendra A Becker, Joseph B Kim, Rosa R Woodrum, Joanne Liang, Stephen F Derose
Rationale- Automated telemedicine interventions could potentially improve adherence to continuous positive airway pressure therapy (CPAP). Objective-Examining the effects of telemedicine-delivered obstructive sleep apnea (OSA) education and CPAP telemonitoring with automated patient feedback messaging on CPAP adherence. Methods-This 4-arm, randomized, factorial-design clinical trial enrolled 1455 patients (51.0% women, age 49.1±12.5 years) referred for suspected OSA. 956 underwent home sleep apnea testing and 556 were prescribed CPAP...
August 31, 2017: American Journal of Respiratory and Critical Care Medicine
Xunhai Zheng, Geoffrey A Mueller, Kyungmin Kim, Lalith Perera, Eugene F DeRose, Robert E London
Recent structural characterizations of the p51 and p66 monomers have established an important starting point for understanding the maturation pathway of the human immunodeficiency virus (HIV)-1 reverse transcriptase p66/p51 heterodimer. This process requires a metamorphic transition of the polymerase domain leading to formation of a p66/p66' homodimer that exists as a structural heterodimer. To better understand the drivers for this metamorphic transition, we have performed NMR studies of (15)N-labeled RT216 - a construct that includes the fingers and most of the palm domains...
September 24, 2017: Biochemical Journal
Galina Leyvi, Kumar Vivek, Sankalp Sehgal, Adrienne Warrick, Kea Alexa Moncada, Nancy Shilian, Jonathan D Leff, Robert E Michler, Joseph J DeRose
OBJECTIVE: The inflammatory response elicited by robotically enhanced coronary artery bypass grafting (r-CABG) has not been well described. When r-CABG is performed as part of hybrid coronary revascularization, the inflammatory milieu and the timing of percutaneous coronary intervention may affect the stent patency negatively in the short and long term. The goal of this study was to describe the extent and time course of cytokine release after r-CABG compared with conventional CABG (c-CABG) and to elucidate the optimal timing for r-CABG in the setting of hybrid coronary revascularization for a future study...
April 26, 2017: Journal of Cardiothoracic and Vascular Anesthesia
Geoffrey A Mueller, Peter M Thompson, Eugene F DeRose, Thomas M O'Connell, Robert E London
BACKGROUND: Studies on ragweed and birch pollen extracts suggested that the adenosine content is an important factor in allergic sensitization. However, exposure levels from other pollens and considerations of geographic and seasonal factors have not been evaluated. OBJECTIVE: This study compared the metabolite profile of pollen species important for allergic disease, specifically measured the adenosine content, and evaluated exposure to pollen-derived adenosine...
December 2016: Metabolomics: Official Journal of the Metabolomic Society
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