Read by QxMD icon Read


Adam M Saunders, Victoria J DeRose
It is well-known that RNA structure and function depend heavily on cations, and the ability of Mg(2+) to stabilize RNA structures has been emphasized. Recent studies, however, highlight the importance of transition metals in RNA function. Riboswitches that selectively bind Ni(2+), Co(2+), and Mn(2+) have been discovered with specific RNA-metal sites that influence metal-related gene expression. Exogenous metals such as Pt(II) from therapeutics also bind and may inhibit cellular RNA function. Novel reports that RNA can host Fe(II) in catalytic sites are relevant to early life in pre-oxygenic atmospheres...
September 5, 2016: Current Opinion in Chemical Biology
Nicholas J D Martinez, Christopher T Derose, Reinhard W Brock, Andrew L Starbuck, Andrew T Pomerene, Anthony L Lentine, Douglas C Trotter, Paul S Davids
We present experimental results for a selective epitaxially grown Ge-on-Si separate absorption and charge multiplication (SACM) integrated waveguide coupled avalanche photodiode (APD) compatible with our silicon photonics platform. Epitaxially grown Ge-on-Si waveguide-coupled linear mode avalanche photodiodes with varying lateral multiplication regions and different charge implant dimensions are fabricated and their illuminated device characteristics and high-speed performance is measured. We report a record gain-bandwidth product of 432 GHz for our highest performing waveguide-coupled avalanche photodiode operating at 1510nm...
August 22, 2016: Optics Express
Kyung Taek Oh, Joseph Derose, Cynthia Taub
Complete dehiscence of a composite aortic valve graft with pseudoaneurysm formation is a rare complication following aortic root replacement. This complication often takes place in the setting of acute graft infection and accompanies symptoms of heart failure, valve insufficiency or sepsis. We present a delayed, asymptomatic presentation of this complication in a young man with distant history of aortic root replacement and medically treated prosthetic valve endocarditis a year postoperatively. He had been non-adherent to warfarin over 10 years, but otherwise maintained a healthy life...
2016: BMJ Case Reports
John D Puskas, Michael E Halkos, Joseph J DeRose, Emilia Bagiella, Marissa A Miller, Jessica Overbey, Johannes Bonatti, V S Srinivas, Mark Vesely, Francis Sutter, Janine Lynch, Katherine Kirkwood, Timothy A Shapiro, Konstantinos D Boudoulas, Juan Crestanello, Thomas Gehrig, Peter Smith, Michael Ragosta, Steven J Hoff, David Zhao, Annetine C Gelijns, Wilson Y Szeto, Giora Weisz, Michael Argenziano, Thomas Vassiliades, Henry Liberman, William Matthai, Deborah D Ascheim
BACKGROUND: Hybrid coronary revascularization (HCR) combines minimally invasive surgical coronary artery bypass grafting of the left anterior descending artery with percutaneous coronary intervention (PCI) of non-left anterior descending vessels. HCR is increasingly used to treat multivessel coronary artery disease that includes stenoses in the proximal left anterior descending artery and at least 1 other vessel, but its effectiveness has not been rigorously evaluated. OBJECTIVES: This National Institutes of Health-funded, multicenter, observational study was conducted to explore the characteristics and outcomes of patients undergoing clinically indicated HCR and multivessel PCI for hybrid-eligible coronary artery disease, to inform the design of a confirmatory comparative effectiveness trial...
July 26, 2016: Journal of the American College of Cardiology
Simran K Bhandari, Jiaxiao Shi, Miklos Z Molnar, Scott A Rasgon, Stephen F Derose, Csaba P Kovesdy, David A Calhoun, Kamyar Kalantar-Zadeh, Steven J Jacobsen, John J Sim
BACKGROUND AND OBJECTIVE: We directly compared sleep apnoea (SA) rates and risk of cardiovascular and mortality outcomes among SA patients with resistant hypertension (RH) and non-RH within a large diverse hypertension population. METHODS: A retrospective cohort study between 1 January 2006 and 31 December 2010 among hypertensive adults (age ≥ 18 years) was performed within an integrated health system. Rates of SA in RH and non-RH were determined. Multivariable logistic regression analyses were used to calculate OR for SA...
July 18, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Rebecca L McMahen, Mark J Strynar, Larry McMillan, Eugene DeRose, Andrew B Lindstrom
Fipronil is a phenylpyrazole insecticide that is widely used in residential and agricultural settings to control ants, roaches, termites, and other pests. Fipronil and its transformation products have been found in a variety of environmental matrices, but the source[s] which makes the greatest contribution to fipronil in surface water has yet to be determined. A sampling effort designed to prioritize known fipronil inputs (golf courses, residential areas, biosolids application sites and wastewater facilities) was conducted in North Carolina to learn more about the origins of fipronil in surface water...
November 1, 2016: Science of the Total Environment
Deborah Cohen, Bing Han, Kathryn P Derose, Stephanie Williamson, Aaron Paley, Christina Batteate
Physical activity is beneficial for health, but there are limited opportunities in urban areas to safely access public streets for traffic-free cycling, skating or walking. Ciclovías are open streets programs that close major roads to motor vehicles so they can be exclusively used by bicyclists and pedestrians. We estimated participation in one Los Angeles Ciclovía event (CicLAvia) using intercept surveys and 14 surveillance cameras which were placed along the 6-mile route in April 2014. We also applied estimates of the distance and speed traveled from the use of GPS data acquired from subsequent CicLAvia events...
September 2016: Preventive Medicine
Galina Inzhakova, Hui Zhou, Macdonald Morris, Megan I Early, Anny H Xiang, Steven J Jacobsen, Stephen F Derose
OBJECTIVES: We evaluated an alternative way to implement guidelines using an automated risk calculator and risk-based decision tool to calculate patients' risk of cardiovascular disease (CVD) and recommend therapies. We compared such an approach with traditional guidelines. STUDY DESIGN: A retrospective cohort study of 1,506,109 Kaiser Permanente Southern California members 35 years or older. METHODS: We estimated 3-year risks of fatal and nonfatal myocardial infarction and stroke using an independently developed risk calculator, then graphically compared risks with observed outcomes...
2016: American Journal of Managed Care
Tomo Ando, Anthony A Holmes, Cynthia C Taub, David P Slovut, Joseph J DeRose
BACKGROUND: Ventricular septal defects (VSD) are rarely reported as a complication following transcatheter aortic valve replacement (TAVR). We sought to characterise the patients, clinical management, and outcomes regarding this rare phenomenon. METHODS: Relevant articles were identified by a systematic search of MEDLINE and EMBASE databases from January, 2002 to September, 2015. RESULTS: A total of 18 case reports, including 20 patients, were identified...
October 2016: Heart, Lung & Circulation
Jared J Liebelt, Yuanquan Yang, Joseph J DeRose, Cynthia C Taub
Ventricular septal rupture (VSR) is a rare but devastating complication after acute myocardial infarction (AMI). While the incidence has decreased, the mortality rate from VSR has remained extremely high. The use of mechanical circulatory support with intra-aortic balloon pump (IABP) and extracorporal membrane oxygenation (ECMO) may be useful in providing hemodynamic stability and time for myocardial scarring. However, the optimal timing for surgical repair remains an enigma. Retrospective analysis of 14 consecutive patients diagnosed with VSR after AMI at Montefiore Medical Center between January 2009 and June 2015...
2016: American Journal of Cardiovascular Disease
Deborah A Cohen, Bing Han, Kathryn P Derose, Stephanie Williamson, Terry Marsh, Laura Raaen, Thomas L McKenzie
Concerns about safety and perceived threats have been considered responsible for lower use of parks in high poverty neighborhoods. To quantify the role of perceived threats on park use we systematically observed 48 parks and surveyed park users and household residents in low-income neighborhoods in the City of Los Angeles. Across all parks, the majority of both park users and local residents perceive parks as safe or very safe. We noted apparently homeless individuals during nearly half of all observations, but very few instances of fighting, intimidating groups, smoking and intoxication...
January 2016: Environment and Behavior
Robert E Michler, Peter K Smith, Michael K Parides, Gorav Ailawadi, Vinod Thourani, Alan J Moskowitz, Michael A Acker, Judy W Hung, Helena L Chang, Louis P Perrault, A Marc Gillinov, Michael Argenziano, Emilia Bagiella, Jessica R Overbey, Ellen G Moquete, Lopa N Gupta, Marissa A Miller, Wendy C Taddei-Peters, Neal Jeffries, Richard D Weisel, Eric A Rose, James S Gammie, Joseph J DeRose, John D Puskas, François Dagenais, Sandra G Burks, Ismail El-Hamamsy, Carmelo A Milano, Pavan Atluri, Pierre Voisine, Patrick T O'Gara, Annetine C Gelijns
BACKGROUND: In a trial comparing coronary-artery bypass grafting (CABG) alone with CABG plus mitral-valve repair in patients with moderate ischemic mitral regurgitation, we found no significant difference in the left ventricular end-systolic volume index (LVESVI) or survival after 1 year. Concomitant mitral-valve repair was associated with a reduced prevalence of moderate or severe mitral regurgitation, but patients had more adverse events. We now report 2-year outcomes. METHODS: We randomly assigned 301 patients to undergo either CABG alone or the combined procedure...
May 19, 2016: New England Journal of Medicine
Adam M Saunders, Victoria J DeRose
It is well-known that RNA structure and function depend heavily on cations, and the ability of Mg(2+) to stabilize RNA structures has been emphasized. Recent studies, however, highlight the importance of transition metals in RNA function. Riboswitches that selectively bind Ni(2+), Co(2+), and Mn(2+) have been discovered with specific RNA-metal sites that influence metal-related gene expression. Exogenous metals such as Pt(II) from therapeutics also bind and may inhibit cellular RNA. Novel reports that RNA can host Fe(II) in catalytic sites are relevant to early life in pre-oxygenic atmospheres...
April 2016: Current Opinion in Chemical Biology
Kathryn P Derose, Beth Ann Griffin, David E Kanouse, Laura M Bogart, Malcolm V Williams, Ann C Haas, Karen R Flórez, Deborah Owens Collins, Jennifer Hawes-Dawson, Michael A Mata, Clyde W Oden, Brian D Stucky
HIV-related stigma and mistrust contribute to HIV disparities. Addressing stigma with faith partners may be effective, but few church-based stigma reduction interventions have been tested. We implemented a pilot intervention with 3 Latino and 2 African American churches (4 in matched pairs) in high HIV prevalence areas of Los Angeles County to reduce HIV stigma and mistrust and increase HIV testing. The intervention included HIV education and peer leader workshops, pastor-delivered sermons on HIV with imagined contact scenarios, and HIV testing events...
August 2016: AIDS and Behavior
Clara Beaver, Morris A Magnan, Denise Henderson, Patricia DeRose, Kathleen Carolin, Gerold Bepler
A nursing quality consortium standardized nursing practice across 17 independently functioning ambulatory oncology sites. Programs were developed to validate both competences and competencies. One program assessed nine competences needed to develop systems of care to detect and treat treatment-related side effects. A second program was developed to assess competencies needed to prevent harm to oncology patients. This manuscript describes a successful approach to standardizing nursing practice across geographically distant academic and community sites...
March 2016: Journal for Nurses in Professional Development
Peter O Weigel, Marc Savanier, Christopher T DeRose, Andrew T Pomerene, Andrew L Starbuck, Anthony L Lentine, Vincent Stenger, Shayan Mookherjea
We demonstrate a photonic waveguide technology based on a two-material core, in which light is controllably and repeatedly transferred back and forth between sub-micron thickness crystalline layers of Si and LN bonded to one another, where the former is patterned and the latter is not. In this way, the foundry-based wafer-scale fabrication technology for silicon photonics can be leveraged to form lithium-niobate based integrated optical devices. Using two different guided modes and an adiabatic mode transition between them, we demonstrate a set of building blocks such as waveguides, bends, and couplers which can be used to route light underneath an unpatterned slab of LN, as well as outside the LN-bonded region, thus enabling complex and compact lightwave circuits in LN alongside Si photonics with fabrication ease and low cost...
2016: Scientific Reports
Wissam N Raad, Stephen Forest, Marco Follis, Patricia Friedmann, Joseph J DeRose
OBJECTIVE: The aim of this study was to compare narcotic use in the perioperative hospital stay as a measure of pain in patients undergoing robotic versus conventional coronary artery bypass grafting (CABG). METHODS: Propensity score matching of patients undergoing robotically assisted CABG and conventional CABG over a period of 5 years was performed. A retrospective chart review was performed to identify the total amount of narcotics used by both groups calculated as morphine equivalent dosing (MED)...
March 2016: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Allen K Kim, Robert DeRose, Tasuku Ueno, Benjamin Lin, Toru Komatsu, Hideki Nakamura, Takanari Inoue
Biological phenomena, such as cellular differentiation and phagocytosis, are fundamental processes that enable cells to fulfill important physiological roles in multicellular organisms. In the field of synthetic biology, the study of these behaviors relies on the use of a broad range of molecular tools that enable the real-time manipulation and measurement of key components in the underlying signaling pathways. This Review will focus on a subset of synthetic biology tools known as bottom-up techniques, which use technologies such as optogenetics and chemically induced dimerization to reconstitute cellular behavior in cells...
February 9, 2016: Science Signaling
Xunhai Zheng, Lars C Pedersen, Scott A Gabel, Geoffrey A Mueller, Eugene F DeRose, Robert E London
Formation of the mature HIV-1 reverse transcriptase (RT) p66/p51 heterodimer requires subunit-specific processing of the p66/p66' homodimer precursor. Since the ribonuclease H (RH) domain contains an occult cleavage site located near its center, cleavage must occur either prior to folding or subsequent to unfolding. Recent NMR studies have identified a slow, subunit-specific RH domain unfolding process proposed to result from a residue tug-of-war between the polymerase and RH domains on the functionally inactive, p66' subunit...
February 29, 2016: Nucleic Acids Research
Kathryn P Derose, Melissa Felician, Bing Han, Kartika Palar, Blanca Ramírez, Hugo Farías, Homero Martínez
BACKGROUND: Food insecurity and poor nutrition are key barriers to anti-retroviral therapy (ART) adherence. Culturally-appropriate and sustainable interventions that provide nutrition counseling for people on ART and of diverse nutritional statuses are needed, particularly given rising rates of overweight and obesity among people living with HIV (PLHIV). METHODS: As part of scale-up of a nutritional counseling intervention, we recruited and trained 17 peer counselors from 14 government-run HIV clinics in Honduras to deliver nutritional counseling to ART patients using a highly interactive curriculum that was developed after extensive formative research on locally available foods and dietary patterns among PLHIV...
2015: BMC Nutrition
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"