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https://www.readbyqxmd.com/read/28187031/x-ray-of-excised-cancerous-breast-tissue-does-not-affect-clinical-biomarker-expression
#1
Isaac E Lloyd, Alana L Welm, Yoko DeRose, Leigh A Neumayer, Jessica L Kohan, Elisabeth M Malmberg, Mohamed E Salama, Rachel E Factor
CONTEXT: College of American Pathologists (CAP) and the American Society of Clinical Oncology have emphasized the need to reduce preanalytic variables for evaluating predictive biomarker expression in breast cancer. Postoperative x-ray of excised breast tissue is commonplace, yet is a variable that has not been investigated previously. We asked whether such radiation affects expression of relevant biomarkers. DESIGN: A previous study found that human breast cancers grown in mice demonstrate the same immunohistochemical and molecular profiles as the original tumors...
February 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28163659/achieving-broad-participation-in-congregational-health-surveys-at-african-american-and-latino-churches
#2
Jennifer Hawes-Dawson, Kathryn Pitkin Derose, Frances M Aunon, Blanca X Dominguez, Alexandria Felton, Michael A Mata, Clyde W Oden, Sandra Paffen
Congregation-based health program evaluations often rely on surveys, but little documentation is available regarding specific methods and challenges. Here we describe methods used to achieve acceptable response rates (73-79%) to a survey of HIV-related attitudes and behaviors in 2 African American and 3 Latino churches in high HIV prevalence communities in Los Angeles County. Survey participation was enhanced by: conducting survey sessions at church-based meetings (e.g., women's Bible study) and after worship services; employing diverse survey staff; providing participation incentives for pastors, church coordinators, and survey participants; and working collaboratively and respectfully with congregational leaders...
February 2017: Field Methods
https://www.readbyqxmd.com/read/28123208/church-based-hiv-screening-in-racial-ethnic-minority-communities-of-california-2011-2012
#3
Malcolm V Williams, Kathryn Pitkin Derose, Frances Aunon, David E Kanouse, Laura M Bogart, Beth Ann Griffin, Ann C Haas, Deborah Owens Collins
Community-based human immunodeficiency virus (HIV) testing at religious congregations has been proposed as a potentially effective way to increase screening among disproportionately affected populations, such as those self-identifying as African American and Latino. Although congregations may provide reach into these communities, the extent to which church-based HIV testing alleviates access barriers, identifies new cases, and reaches people at increased risk for HIV is not well documented. We examined the results of an HIV testing program that was conducted as part of a larger intervention aimed at reducing HIV stigma at five churches in Los Angeles County, California, in 2011-2012...
September 2016: Public Health Reports
https://www.readbyqxmd.com/read/28069843/nearly-one-third-of-enrollees-in-california-s-individual-market-missed-opportunities-to-receive-financial-assistance
#4
Vicki Fung, Catherine Y Liang, Karen Donelan, Cassandra G K Peitzman, William H Dow, Alan M Zaslavsky, Bruce Fireman, Stephen F Derose, Michael E Chernew, Joseph P Newhouse, John Hsu
The Affordable Care Act includes financial assistance that reduces both premiums and cost-sharing amounts for lower-income Americans, to increase the affordability of health insurance coverage and care. To receive both types of assistance, enrollees must purchase a qualified health plan through a public insurance exchange, and those eligible for the cost-sharing reduction must purchase a silver-tier plan. We estimate that 31 percent of individual-market enrollees in California who were likely eligible for financial assistance purchased plans that were not silver tier or that were not sold on the state's exchange and thus missed opportunities to receive premium or cost-sharing assistance or both...
January 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28028224/ape2-zf-grf-facilitates-3-5-resection-of-dna-damage-following-oxidative-stress
#5
Bret D Wallace, Zachary Berman, Geoffrey A Mueller, Yunfeng Lin, Timothy Chang, Sara N Andres, Jessica L Wojtaszek, Eugene F DeRose, C Denise Appel, Robert E London, Shan Yan, R Scott Williams
The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'-5' nucleolytic resection of oxidative DNA damage and activation of the ATR-Chk1 DNA damage response (DDR) pathway via ill-defined mechanisms. Here we report that APE2 resection activity is regulated by DNA interactions in its Zf-GRF domain, a region sharing high homology with DDR proteins Topoisomerase 3α (TOP3α) and NEIL3 (Nei-like DNA glycosylase 3), as well as transcription and RNA regulatory proteins, such as TTF2 (transcription termination factor 2), TFIIS, and RPB9...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27974415/loss-of-rasgap-tumor-suppressors-underlies-the-aggressive-nature-of-luminal-b-breast-cancers
#6
Sarah Naomi Olsen, Ania Wronski, Zafira Castaño, Benjamin Dake, Clare Malone, Thomas De Raedt, Miriam Enos, Yoko S DeRose, Wenhui Zhou, Stephanie Guerra, Massimo Loda, Alana Welm, Ann H Partridge, Sandra S McAllister, Charlotte Kuperwasser, Karen Cichowski
Luminal breast cancers are typically estrogen receptor-positive and generally have the best prognosis. However, a subset of luminal tumors, namely luminal B cancers, frequently metastasize and recur. Unfortunately, the causal events that drive their progression are unknown, and therefore it is difficult to identify individuals who are likely to relapse and should receive escalated treatment. Here, we identify a bifunctional RasGAP tumor suppressor whose expression is lost in almost 50% of luminal B tumors. Moreover, we show that two RasGAP genes are concomitantly suppressed in the most aggressive luminal malignancies...
December 14, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27927587/estimated-gfr-before-and-after-bariatric-surgery-in-ckd
#7
Talha H Imam, Heidi Fischer, Bocheng Jing, Raoul Burchette, Shayna Henry, Stephen F DeRose, Karen J Coleman
BACKGROUND: Several reviews have recently detailed the beneficial effects of weight loss surgery for kidney function. However, these studies have a number of limitations, including small sample size, few done in chronic kidney disease (CKD) stages 3 and 4, and many not including the main bariatric surgery procedures used in the United States today. STUDY DESIGN: This was an observational retrospective cohort study comparing propensity score-matched bariatric surgery patients and nonsurgery control patients who were referred for, but did not have, surgery...
March 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27906331/compact-silicon-photonic-resonance-sssisted-variable-optical-attenuator
#8
Xiaoxi Wang, Ryan Aguinaldo, Anthony Lentine, Christopher DeRose, Andrew L Starbuck, Douglas Trotter, Andrew Pomerene, Shayan Mookherjea
A two-part silicon photonic variable optical attenuator is demonstrated in a compact footprint which can provide a high extinction ratio at wavelengths between 1520 nm and 1620 nm. The device was made by following the conventional p-i-n waveguide section by a high-extinction-ratio second-order microring filter section. The rings provide additional on-off contrast by utilizing a thermal resonance shift, which harvested the heat dissipated by current injection in the p-i-n junction. We derive and discuss a simple thermal-resistance model in explanation of these effects...
November 28, 2016: Optics Express
https://www.readbyqxmd.com/read/27884484/ross-hybrid-arch-and-frozen-elephant-trunk-reconstruction-for-late-complications-of-bicuspid-aortic-valve-and-aortopathy
#9
Matthew Valdis, Gaetano DeRose, Linrui Guo, Michael W A Chu
Young patients with bicuspid aortic valve disease and aortopathy remain a clinical challenge, with many requiring multiple corrective operations throughout their lifetimes. Innovative surgical approaches are often required to address complex aortic pathologic conditions but leave patients at risk for reintervention, lifelong anticoagulation, and suboptimal hemodynamics. We describe an active 44-year-old female triathlete with recurrent bicuspid aortic stenosis, a small aortic root, a hypoplastic aortic arch and complex distal arch, and a descending aortic aneurysm, who underwent a single-stage reconstruction with a combined Ross procedure, hybrid arch, and frozen elephant trunk reconstruction...
December 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27876520/explaining-endograft-shortening-during-endovascular-repair-of-abdominal-aortic-aneurysms-in-severe-aortoiliac-tortuosity
#10
Kevin Lee, Sajjid Hossain, Maher Sabalbal, Luc Dubois, Audra Duncan, Guy DeRose, Adam H Power
OBJECTIVE: During endovascular aneurysm repair (EVAR), severely tortuous aortoiliac anatomy can alter the deployment and conformability of the endograft. The accuracy of treatment length measurements is commonly recognized to be affected by severe tortuosity. However, the exact mechanism of the postintervention length discrepancy is poorly understood. The objective of this study was to determine the mechanism of how severe aortoiliac tortuosity influences the endograft and native aorta during EVAR and its impact on the distal sealing zone...
November 19, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27855673/gender-and-physician-specialization-and-practice-settings-in-ecuador-a-qualitative-study
#11
Rita Bedoya-Vaca, Kathryn P Derose, Natalia Romero-Sandoval
BACKGROUND: The increasing proportion of women in the medical profession is a worldwide phenomenon often called the "feminization of medicine." However, it is understudied in low and middle-income countries, particularly in Latin America. METHODS: Using a qualitative, descriptive design, we explored the influence of gender and other factors on physician career decision-making and experiences, including medical specialty and public vs. private practice, in Quito, Ecuador, through in-depth, semi-structured interviews (n = 31) in 2014...
November 17, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27828374/wide-range-and-fast-thermally-tunable-silicon-photonic-microring-resonators-using-the-junction-field-effect
#12
Xiaoxi Wang, Anthony Lentine, Christopher DeRose, Andrew L Starbuck, Douglas Trotter, Andrew Pomerene, Shayan Mookherjea
Tunable silicon microring resonators with small, integrated micro-heaters which exhibit a junction field effect were made using a conventional silicon-on-insulator (SOI) photonic foundry fabrication process. The design of the resistive tuning section in the microrings included a "pinched" p-n junction, which limited the current at higher voltages and inhibited damage even when driven by a pre-emphasized voltage waveform. Dual-ring filters were studied for both large (>4.9 THz) and small (850 GHz) free-spectral ranges...
October 3, 2016: Optics Express
https://www.readbyqxmd.com/read/27616014/beyond-mg-2-functional-interactions-between-rna-and-transition-metals
#13
Adam M Saunders, Victoria J DeRose
It is well-known that RNA structure and function depend heavily on cations, and the ability of Mg(2+) to stabilize RNA structures has been emphasized. Recent studies, however, highlight the importance of transition metals in RNA function. Riboswitches that selectively bind Ni(2+), Co(2+), and Mn(2+) have been discovered with specific RNA-metal sites that influence metal-related gene expression. Exogenous metals such as Pt(II) from therapeutics also bind and may inhibit cellular RNA function. Novel reports that RNA can host Fe(II) in catalytic sites are relevant to early life in pre-oxygenic atmospheres...
September 5, 2016: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/27557187/high-performance-waveguide-coupled-ge-on-si-linear-mode-avalanche-photodiodes
#14
Nicholas J D Martinez, Christopher T Derose, Reinhard W Brock, Andrew L Starbuck, Andrew T Pomerene, Anthony L Lentine, Douglas C Trotter, Paul S Davids
We present experimental results for a selective epitaxially grown Ge-on-Si separate absorption and charge multiplication (SACM) integrated waveguide coupled avalanche photodiode (APD) compatible with our silicon photonics platform. Epitaxially grown Ge-on-Si waveguide-coupled linear mode avalanche photodiodes with varying lateral multiplication regions and different charge implant dimensions are fabricated and their illuminated device characteristics and high-speed performance is measured. We report a record gain-bandwidth product of 432 GHz for our highest performing waveguide-coupled avalanche photodiode operating at 1510nm...
August 22, 2016: Optics Express
https://www.readbyqxmd.com/read/27530875/fortune-or-misfortune-asymptomatic-delayed-presentation-of-complete-dehiscence-of-mechanical-aortic-valve-conduit-and-pseudoaneurysm
#15
Kyung Taek Oh, Joseph Derose, Cynthia Taub
Complete dehiscence of a composite aortic valve graft with pseudoaneurysm formation is a rare complication following aortic root replacement. This complication often takes place in the setting of acute graft infection and accompanies symptoms of heart failure, valve insufficiency or sepsis. We present a delayed, asymptomatic presentation of this complication in a young man with distant history of aortic root replacement and medically treated prosthetic valve endocarditis a year postoperatively. He had been non-adherent to warfarin over 10 years, but otherwise maintained a healthy life...
August 16, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27443431/hybrid-coronary-revascularization-for%C3%A2-the%C3%A2-treatment-of-multivessel-coronary%C3%A2-artery-disease-a-multicenter-observational-study
#16
John D Puskas, Michael E Halkos, Joseph J DeRose, Emilia Bagiella, Marissa A Miller, Jessica Overbey, Johannes Bonatti, V S Srinivas, Mark Vesely, Francis Sutter, Janine Lynch, Katherine Kirkwood, Timothy A Shapiro, Konstantinos D Boudoulas, Juan Crestanello, Thomas Gehrig, Peter Smith, Michael Ragosta, Steven J Hoff, David Zhao, Annetine C Gelijns, Wilson Y Szeto, Giora Weisz, Michael Argenziano, Thomas Vassiliades, Henry Liberman, William Matthai, Deborah D Ascheim
BACKGROUND: Hybrid coronary revascularization (HCR) combines minimally invasive surgical coronary artery bypass grafting of the left anterior descending artery with percutaneous coronary intervention (PCI) of non-left anterior descending vessels. HCR is increasingly used to treat multivessel coronary artery disease that includes stenoses in the proximal left anterior descending artery and at least 1 other vessel, but its effectiveness has not been rigorously evaluated. OBJECTIVES: This National Institutes of Health-funded, multicenter, observational study was conducted to explore the characteristics and outcomes of patients undergoing clinically indicated HCR and multivessel PCI for hybrid-eligible coronary artery disease, to inform the design of a confirmatory comparative effectiveness trial...
July 26, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27427469/comparisons-of-sleep-apnoea-rate-and-outcomes-among-patients-with-resistant-and-non-resistant-hypertension
#17
Simran K Bhandari, Jiaxiao Shi, Miklos Z Molnar, Scott A Rasgon, Stephen F Derose, Csaba P Kovesdy, David A Calhoun, Kamyar Kalantar-Zadeh, Steven J Jacobsen, John J Sim
BACKGROUND AND OBJECTIVE: We directly compared sleep apnoea (SA) rates and risk of cardiovascular and mortality outcomes among SA patients with resistant hypertension (RH) and non-RH within a large diverse hypertension population. METHODS: A retrospective cohort study between 1 January 2006 and 31 December 2010 among hypertensive adults (age ≥ 18 years) was performed within an integrated health system. Rates of SA in RH and non-RH were determined. Multivariable logistic regression analyses were used to calculate OR for SA...
July 18, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27378152/comparison-of-fipronil-sources-in-north-carolina-surface-water-and-identification-of-a-novel-fipronil-transformation-product-in-recycled-wastewater
#18
Rebecca L McMahen, Mark J Strynar, Larry McMillan, Eugene DeRose, Andrew B Lindstrom
Fipronil is a phenylpyrazole insecticide that is widely used in residential and agricultural settings to control ants, roaches, termites, and other pests. Fipronil and its transformation products have been found in a variety of environmental matrices, but the source[s] which makes the greatest contribution to fipronil in surface water has yet to be determined. A sampling effort designed to prioritize known fipronil inputs (golf courses, residential areas, biosolids application sites and wastewater facilities) was conducted in North Carolina to learn more about the origins of fipronil in surface water...
November 1, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27317978/ciclavia-evaluation-of-participation-physical-activity-and-cost-of-an-open-streets-event-in-los-angeles
#19
Deborah Cohen, Bing Han, Kathryn P Derose, Stephanie Williamson, Aaron Paley, Christina Batteate
Physical activity is beneficial for health, but there are limited opportunities in urban areas to safely access public streets for traffic-free cycling, skating or walking. Ciclovías are open streets programs that close major roads to motor vehicles so they can be exclusively used by bicyclists and pedestrians. We estimated participation in one Los Angeles Ciclovía event (CicLAvia) using intercept surveys and 14 surveillance cameras which were placed along the 6-mile route in April 2014. We also applied estimates of the distance and speed traveled from the use of GPS data acquired from subsequent CicLAvia events...
September 2016: Preventive Medicine
https://www.readbyqxmd.com/read/27266582/potential-of-risk-based-population-guidelines-to-reduce-cardiovascular-risk-in-a-large-integrated-health-system
#20
Galina Inzhakova, Hui Zhou, Macdonald Morris, Megan I Early, Anny H Xiang, Steven J Jacobsen, Stephen F Derose
OBJECTIVES: We evaluated an alternative way to implement guidelines using an automated risk calculator and risk-based decision tool to calculate patients' risk of cardiovascular disease (CVD) and recommend therapies. We compared such an approach with traditional guidelines. STUDY DESIGN: A retrospective cohort study of 1,506,109 Kaiser Permanente Southern California members 35 years or older. METHODS: We estimated 3-year risks of fatal and nonfatal myocardial infarction and stroke using an independently developed risk calculator, then graphically compared risks with observed outcomes...
2016: American Journal of Managed Care
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