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stretch marks

Robert N Goldstone, Michael C McCormack, Rachel L Goldstein, Srivalleesha Mallidi, Mark A Randolph, Michael T Watkins, Robert W Redmond, William G Austen
OBJECTIVE: We hypothesized that decreasing vein compliance would protect the vein against stretch injury and reduce intimal hyperplasia (IH). BACKGROUND: Although arteriovenous fistulas (AVFs) are the criterion standard for vascular access, their effectiveness is limited by poor patency with 40% to 60% failing due to IH. Venous stretch injury from exposure to arterial pressure induces IH. Photochemical tissue passivation (PTP) crosslinks adventitial collagen, decreasing vein compliance to resemble that of an artery...
October 17, 2016: Annals of Surgery
Isabel López-García, Domokos Gerő, Bartosz Szczesny, Petra Szoleczky, Gabor Olah, Katalin Módis, Kangling Zhang, Gao Jungling, Ping Wu, Lawrence C Sowers, Doug DeWitt, Donald S Prough, Csaba Szabo
BACKGROUND AND PURPOSE: We hypothesized that an in vitro, stretch-based model of neural injury may be useful to identify compounds that decrease the cellular damage in neurotrauma. EXPERIMENTAL APPROACH: We screened three neural cell lines (B35, RN33B, SH-SY5Y) subjected to two differentiation methods and selected all-trans-retinoic acid-differentiated B35 rat neuroblastoma cells subjected to rapid stretch injury, coupled with a subthreshold concentration of H2 O2 , for the screen...
October 9, 2016: British Journal of Pharmacology
Jonathan D Pegan, Jasmine Zhang, Michael Chu, Thao Nguyen, Sun-Jun Park, Akshay Paul, Joshua Kim, Mark Bachman, Michelle Khine
This work presents a wrinkled Platinum (wPt) strain sensor with tunable strain sensitivity for applications in wearable health monitoring. These stretchable sensors show a dynamic range of up to 185% strain and gauge factor (GF) of 42. This is believed to be the highest reported GF of any metal thin film strain sensor over a physiologically relevant dynamic range to date. Importantly, sensitivity and dynamic range are tunable to the application by adjusting wPt film thickness. Performance is reliable over 1000 cycles with low hysteresis after sensor conditioning...
October 6, 2016: Nanoscale
Aditi Bhattacherjee, Sanjay Wategaonkar
The imidazole group, characterized by an activated C(2)-H bond sandwiched between two N atoms, occurs in several biomolecules including alkaloids, amino acids, and nucleobases. The speculated role of this potential hydrogen bond donor in shaping the solvation shell around the neutral imidazole moiety, however, remains unidentified. In contrast, hydrogen bonding and electrostatic interactions are commonly observed in the imidazolium cation where the acidity of the C(2)-H bond is markedly enhanced. Here, we show direct evidence of the weakly activated C(2)-H bond in shaping the solvation shell of neutral imidazole, via spectroscopic characterization of the water clusters (Wn, n = 2-4) of two model compounds, benzimidazole (BIM) and N-methylbenzimidazole (MBIM)...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
Junghwa Cha, Hyunjae Shin, Pilnam Kim
A bioinspired fluidic system with cracks and folds was introduced to emulate the structures and functions of desert lizards' integuments, which show marked ability of water management. Since there was a structural analogy between scales and interscalar channels of lizard's skin and cracks and folds of a bilayer elastic material, we can mimic lizard's skin by controlling the stress distribution on patterned elastomers. Our system showed not only capillary-driven water retention within confined fluidic network, but also stretching-driven biaxial water transport...
October 5, 2016: ACS Applied Materials & Interfaces
Christian Bakholdt Dibbern, Morten Rose, Mark Bremholm Ellebæk, Niels Qvist
Introduction One in 4,000 infants is born with oesophageal atresia. Approximately 15% of these have a long gap oesophageal atresia, where primary anastomosis is difficult or impossible. Previous studies have shown an effect of intramural botulinum toxin type A (BTX-A) injections on the elongation and max load of the esophagus 1 hour after injection. We hypothesized that a longer waiting period of 2 hours could increase this effect. Methods Forty-five piglets were randomized into three groups. Two treatment groups received 2 units/kg of BTX-A and one group received saline...
October 3, 2016: European Journal of Pediatric Surgery
P A Postigo, R Alvaro, A Juarros, S Merino
The fabrication of a novel optofluidic chip using nanochannels optimized for DNA-stretched molecules and optical detection by enhanced fluorescence is reported. The chips are composed of a series of microchannels that allow the transport of molecules in the femto-liter per second inside a fluid or gas. The nanochannels are surrounded by a photonic crystal structure to enhance the emission of fluorescent light from the molecules, which can travel along the nanochannel, allowing for enhanced optical detection of the molecules in motion...
September 1, 2016: Biomedical Optics Express
William P Adams, Dean M Toriumi, Bruce W Van Natta
: Resolution of ptosis is a key step to the success of many plastic surgery procedures. Ptosis is a manifestation of tissue stretch. Tissue stretch can occur as a result of the natural aging process or health of the patient, or tissue may stretch under added weight or volume, such as when implants are placed. Surgical rejuvenation of ptotic tissues is very effective and results in marked changes in the patient profile yet the tissue that resulted in the need for the procedure first place has not improved and ptosis can recur...
October 3, 2016: Aesthetic Surgery Journal
Amanda M Hall, Bethan Copsey, Mark Williams, Cynthia Srikesavan, Sarah E Lamb
OBJECTIVE: To determine whether the effect of the 'Strengthening And stretching for Rheumatoid Arthritis of the Hand' (SARAH) exercise programme on hand function was mediated by changes in the proposed active ingredients: strength, dexterity, and/or range of motion. METHODS: The SARAH intervention included exercises hypothesized to improve potential mediators of grip strength, pinch strength, wrist flexion, wrist extension, finger flexion, finger extension, thumb opposition, and dexterity, which would theoretically improve self-reported hand function...
October 1, 2016: Arthritis Care & Research
Christina Vrahnas, Thomas A Pearson, Athena R Brunt, Mark R Forwood, Keith R Bambery, Mark J Tobin, T John Martin, Natalie A Sims
Intermittent administration of parathyroid hormone (PTH) is used to stimulate bone formation in patients with osteoporosis. A reduction in the degree of matrix mineralisation has been reported during treatment, which may reflect either production of undermineralised matrix or a greater proportion of new matrix within the bone samples assessed. To explore these alternatives, high resolution synchrotron-based Fourier Transform Infrared Microspectroscopy (sFTIRM) coupled with calcein labelling was used in a region of non-remodelling cortical bone to determine bone composition during anabolic PTH treatment compared with region-matched samples from controls...
September 28, 2016: Bone
Sanliang Ling, Maciej Gutowski
Computational results have been reported for 2'-deoxycytidine (dC), its gas phase isomers, tautomers, and their conformers, as well as for the crystalline phase. In addition to the neutral gas phase molecules, we have also considered associated radical anions and cations. The structural calculations were performed at the density functional and MP2 levels of theory. Vertical electron ionization energies and excess electron binding energies were determined using electron propagator theory. The α-anomer proved to be more stable by a fraction of kcal/mol than the biologically relevant canonical β-anomer...
October 6, 2016: Journal of Physical Chemistry. A
Justin Stull, Suneel Bhat, Andrew J Miller, Ryan Hoffman, Mark L Wang
Compartment syndrome is an orthopedic emergency with a multitude of etiologies. Although it is most commonly associated with trauma to the extremity, hematoma and infection are 2 rare etiologies of insidious compartment syndrome. Proteus mirabilis is an opportunistic gram-negative species that can infect the respiratory tract, urinary tract, and open wounds. The authors present the case of a 69-year-old woman who developed tissue necrosis and compartment syndrome secondary to an untreated hematoma infected by P mirabilis...
September 29, 2016: Orthopedics
Angela Yulia, Natasha Singh, Kaiyu Lei, Suren R Sooranna, Mark R Johnson
The factors that initiate human labor are poorly understood. We have tested the hypothesis that a decline in cAMP/PKA function leads to the onset of labor. Initially, we identified myometrial cAMP/PKA responsive genes (6 up-regulated and 5 down-regulated genes) and assessed their expression in myometrial samples taken from different stages of pregnancy and labor. We found that the oxytocin receptor (OTR) was one of the cAMP repressed genes and, given the importance of OTR in the labor process, we studied the mechanisms involved in greater detail using siRNA, chemical agonists and antagonists of the cAMP effectors...
September 27, 2016: Endocrinology
Roger Newport, Kelly Auty, Mark Carey, Katie Greenfield, Ellen M Howard, Natasha Ratcliffe, Hayley Thair, Kristy Themelis
If British teenage boy asks you to pull his finger, it is usually an indication that he simultaneously wishes to break wind. If you were to tell him that you could pull his finger and stretch it to twice its length, you might expect a similarly irreverent response yet when we pulled the fingers of nearly 600 children and adolescents, 93% reported the illusion of stretching. Grossly distorted body representations need not be the preserve of clinical disorders and can reliably be induced in healthy participants across all ages...
October 2015: I-Perception
Mark L Latash
Living systems may be defined as systems able to organize new, biology-specific, laws of physics and modify their parameters for specific tasks. Examples include the force-length muscle dependence mediated by the stretch reflex, and the control of movements with modification of the spatial referent coordinates for salient performance variables. Low-dimensional sets of referent coordinates at a task level are transformed to higher-dimensional sets at lower hierarchical levels in a way that ensures stability of performance...
August 19, 2016: Motor Control
Adel Sepsi, James D Higgins, J S Pat Heslop-Harrison, Trude Schwarzacher
During meiosis, centromeres in some species undergo a series of associations, but the processes and progression to homologous pairing is still a matter of debate. Here, we aimed to correlate meiotic centromere dynamics and early telomere behaviour to the progression of synapotonemal complex (SC) construction in hexaploid wheat (2n=42) by triple immunolabelling of CENH3 protein marking functional centromeres, and SC proteins ASY1 (unpaired lateral elements) and ZYP1 (central elements in synapsed chromosomes)...
September 14, 2016: Plant Journal: for Cell and Molecular Biology
Kris Beattie, Brian P Carson, Mark Lyons, Ian C Kenny
Maximum- and reactive-strength qualities both have important roles in athletic movements and sporting performance. Very little research has investigated the relationship between maximum-strength and reactive-strength. The aim of this study was to investigate the relationship between maximum-strength (isometric mid-thigh pull peak force; IMTP PF) and reactive-strength (drop-jump reactive-strength index; DJ-RSI) variables at 0.3 m, 0.4 m, 0.5 m and 0.6 m box heights. A secondary aim investigated the between- and within-group differences in reactive-strength characteristics between relatively 'strong' and 'weak' athletes...
September 6, 2016: International Journal of Sports Physiology and Performance
Rodrigo Rodriguez-Fernandez, Nawi Ng, Dwidjo Susilo, John Prawira, Michael J Bangs, Rachel M Amiya
BACKGROUND: As the global shift toward non-communicable diseases overlaps with the unfinished agenda of confronting infectious diseases in low- and middle-income countries, epidemiological links across both burdens must be recognized. This study examined the non-communicable disease-infectious disease overlap in the specific comorbidity rates for key diseases in an occupational cohort in Papua, Indonesia. METHODS: Diagnosed cases of ischaemic heart disease, stroke, hypertension, diabetes (types 1 and 2), chronic obstructive pulmonary disease, asthma, cancer, HIV and AIDS, tuberculosis, and malaria were extracted from 22,550 patient records (21,513 men, 1037 women) stored in identical electronic health information systems from two clinic sites in Papua, Indonesia...
2016: BMC Public Health
Donal M O'Sullivan, Deepti Angra
Vicia faba L, is a globally important grain legume whose main centers of diversity are the Fertile Crescent and Mediterranean basin. Because of its small number (six) of exceptionally large and easily observed chromosomes it became a model species for plant cytogenetics the 70s and 80s. It is somewhat ironic therefore, that the emergence of more genomically tractable model plant species such as Arabidopsis and Medicago coincided with a marked decline in genome research on the formerly favored plant cytogenetic model...
2016: Frontiers in Genetics
Christopher M Laine, Akira Nagamori, Francisco J Valero-Cuevas
Voluntary control of force is always marked by some degree of error and unsteadiness. Both neural and mechanical factors contribute to these fluctuations, but how they interact to produce them is poorly understood. In this study, we identify and characterize a previously undescribed neuromechanical interaction where the dynamics of voluntary force production suffice to generate involuntary tremor. Specifically, participants were asked to produce isometric force with the index finger and use visual feedback to track a sinusoidal target spanning 5-9% of each individual's maximal voluntary force level...
2016: Frontiers in Computational Neuroscience
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