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https://www.readbyqxmd.com/read/28435258/quantum-dots-modulate-intracellular-ca-2-level-in-lung-epithelial-cells
#1
Huijuan Yin, Jacopo M Fontana, Johan Solandt, Johnny Israelsson Jussi, Hao Xu, Hjalmar Brismar, Ying Fu
While adverse effects of nanoparticles on lung health have previously been proposed, few studies have addressed the direct effects of nanoparticle exposure on the airway epithelium. In this work, we examine the response of the pulmonary airway to nanoparticles by measuring intracellular Ca(2+) concentration ([Ca(2+)]i) in the Calu-3 epithelial layer stimulated by 3-mercaptopropionic-acid (3MPA) coated CdSe-CdS/ZnS core-multishell quantum dots (QDs). Simultaneous transient transepithelial electrical resistance (TEER) decrease and global [Ca(2+)]i increase in Calu-3 epithelial layer, accompanied by cell displacements, contraction, and expansion, were observed under QD deposition...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28430724/the-effect-of-lithotomy-position-on-nerve-stretch-a-cadaveric-study
#2
Nicolette E Deveneau, Courtney Forbis, Lioudmilla Lipetskaia, Casey L Kinman, Anubhav Agrawal, Nicole R Herring, Sean L Francis
OBJECTIVE: The objective of our study was to design a method to measure nerve stretch in cadaveric subjects and then use the method to assess femoral nerve stretch in the lithotomy position with varying degrees of flexion and extension. METHODS: A university-based, cadaveric observational study of femoral nerve stretch was conducted. In 6 cadaveric subjects, femoral nerve near the inguinal ligament was dissected in each cadaveric subject. The nerve was marked, and digital images of the nerve were obtained in the supine position and lithotomy position in both flexion and extension...
April 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28429939/solute-rotation-in-ionic-liquids-size-shape-and-electrostatic-effects
#3
Christopher A Rumble, Caleb Uitvlugt, Brian Conway, Mark Maroncelli
Herein are reported temperature-dependent measurements and molecular dynamics simulations designed to investigate the effects of molecular size, shape, and electrostatics on rotational dynamics in ionic liquids. Experiments were performed in the representative ionic liquid 1-butyl-3-methylimadazolium tetrafluoroborate ([Im41][BF4]) and simulations in the generic ionic liquid model ILM2 as well as a more detailed representation of [Im41][BF4]. 2H longitudinal spin relaxation times were measured for deuterated versions of 1,4-dimethylbenzene, 1-cyano-4-methylbenzene, and 1,4-dimethylpyridinium between 296-337 K...
April 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28404610/hand-exercises-for-patients-with-rheumatoid-arthritis-an-extended-follow-up-of-the-sarah-randomised-controlled-trial
#4
Esther Williamson, Christopher McConkey, Peter Heine, Sukhdeep Dosanjh, Mark Williams, Sarah E Lamb
OBJECTIVES: The Stretching And strengthening for Rheumatoid Arthritis of the Hand (SARAH) randomised controlled trial evaluated the effectiveness of a hand exercise programme and demonstrated it was clinically effective and cost-effective at 12 months. The aim of this extended follow-up was to evaluate the effects of the SARAH programme beyond 12 months. METHODS: Using postal questionnaires, we collected the Michigan Hand Questionnaire hand function (primary outcome), activities of daily living and work subscales, pain troublesomeness, self-efficacy and health-related quality of life...
April 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28393195/induction-of-mmp%C3%A2-1-and-%C3%A2-3-by-cyclical-mechanical-stretch-is-mediated-by-il%C3%A2-6-in-cultured-fibroblasts-of-keratoconus
#5
Gen-Lai Du, Wei-Yi Chen, Xiao-Na Li, Rui He, Peng-Fei Feng
In order to understand the effect of mechanical stretch on corneal extracellular matrix remodeling, human keratoconus fibroblasts (HKCFBs) were subjected to cyclic stretch in vitro and the expression of matrix metalloproteinases (MMPs), tissue inhibitor of metalloproteinases (TIMPs), and inflammatory cytokines were evaluated. HKCFBs were seeded into a flexible membrane base and subjected to a cyclic stretch regimen of 10% equibiaxial stretch at a stretching frequency of 1 Hz for 6 h using a Flexcell tension unit...
April 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28392258/bilayer-mediated-structural-transitions-control-mechanosensitivity-of-the-trek-2-k2p-channel
#6
Prafulla Aryal, Viwan Jarerattanachat, Michael V Clausen, Marcus Schewe, Conor McClenaghan, Liam Argent, Linus J Conrad, Yin Y Dong, Ashley C W Pike, Elisabeth P Carpenter, Thomas Baukrowitz, Mark S P Sansom, Stephen J Tucker
The mechanosensitive two-pore domain (K2P) K(+) channels (TREK-1, TREK-2, and TRAAK) are important for mechanical and thermal nociception. However, the mechanisms underlying their gating by membrane stretch remain controversial. Here we use molecular dynamics simulations to examine their behavior in a lipid bilayer. We show that TREK-2 moves from the "down" to "up" conformation in direct response to membrane stretch, and examine the role of the transmembrane pressure profile in this process. Furthermore, we show how state-dependent interactions with lipids affect the movement of TREK-2, and how stretch influences both the inner pore and selectivity filter...
March 24, 2017: Structure
https://www.readbyqxmd.com/read/28389179/bone-anchored-intermaxillary-elastics-in-an-asymmetric-class-ii-malocclusion-a-case-report
#7
Antonio Manni, Daniela Lupini, Mauro Cozzani
PURPOSE: A 13-year-old male patient, presenting a Class II, division 1 malocclusion and crowding was treated by an innovative technique. METHODS: After rapid palatal expansion by a Hyrax appliance, the teeth were bonded with straightwire brackets. Two miniscrews were inserted, one per side, in the mandibular buccal bone between the roots of the mandibular first molar and the second premolar. On the right side, the miniscrew implant was connected to the hook clamped on a 0...
April 4, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28388575/cofilin-1-induces-the-epithelial-mesenchymal-transition-of-gastric-cancer-cells-by-promoting-cytoskeletal-rearrangement
#8
Wang Haibo, Tao Lide, Jin Feng, Gu Hao, Dai Xiaojun, Ni Tengyang, Feng Jun, Ding Yanbing, Xiao Weiming, Qian Yayun, Liu Yanqing
Epithelial-mesenchymal transition (EMT) is an important biological process whereby malignant tumor cells obtain the ability to migrate, invade, resist apoptosis and degrade the extracellular matrix. We found that Cofilin1 (CFL1) expression was elevated in clinical gastric cancer specimens and correlated with biomarkers of EMT in BGC-823 gastric cancer cells. BGC-823 cells exhibited EMT phenotypes and increased metastatic ability when induced by TGF-β1. By contrast, BGC-823 cells transfected with Lv-siRNA-CFL1 did not exhibit EMT phenotypes under the same inducing conditions...
March 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28386788/immediate-effects-of-active-exercise-with-compression-therapy-on-lower-limb-lymphedema
#9
Takuya Fukushima, Tetsuya Tsuji, Yufuko Sano, Chieko Miyata, Michiyo Kamisako, Hiroka Hohri, Chikako Yoshimura, Megumi Asakura, Taro Okitsu, Kaori Muraoka, Meigen Liu
PURPOSE: Active exercise with compression therapy (AECT) is a standard treatment for gynecological cancer-related lower-limb lymphedema (LLL) in clinical situations. However, there is insufficient evidence regarding the immediate effects of the use of AECT on LLL. The purpose of this study was to evaluate the immediate effects of AECT on LLL. METHODS: Participants in this randomized controlled crossover trial comprised 23 women with LLL who completed high-load AECT, low-load AECT, and compression-only therapy (CT)...
April 6, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28386214/chaperones-in-polyglutamine-aggregation-beyond-the-q-stretch
#10
REVIEW
E F E Kuiper, Eduardo P de Mattos, Laura B Jardim, Harm H Kampinga, Steven Bergink
Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to inherited neuronal dysfunction and degeneration. The expansion size in all diseases correlates with age at onset (AO) of disease and with polyQ protein aggregation, indicating that the expanded polyQ stretch is the main driving force for the disease onset. Interestingly, there is marked interpatient variability in expansion thresholds for a given disease. Between different polyQ diseases the repeat length vs. AO also indicates the existence of modulatory effects on aggregation of the upstream and downstream amino acid sequences flanking the Q expansion...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28380823/compact-and-versatile-laser-system-for-polarization-sensitive-stimulated-raman-spectroscopy
#11
Hugo Kerdoncuff, Mark R Pollard, Philip G Westergaard, Jan C Petersen, Mikael Lassen
We demonstrate a compact and versatile laser system for stimulated Raman spectroscopy (SRS). The system is based on a tunable continuous wave (CW) probe laser combined with a home-built semi-monolithic nanosecond pulsed pump Nd:YVO<sub>4</sub> laser at 1064 nm. The CW operation of the probe laser offers narrow linewidth, low noise and the advantage that temporal synchronization with the pump is not required. The laser system enables polarization-sensitive stimulated Raman spectroscopy (PS-SRS) with fast high resolution measurement of the depolarization ratio by simultaneous detection of Raman scattered light in orthogonal polarizations, thus providing information about the symmetry of the Raman-active vibrational modes...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28375616/bond-polarizability-model-for-sum-frequency-generation-at-the-al2o3-0001-h2o-interface
#12
Mark DelloStritto, Jorge Sofo
Sum Frequency Generation (SFG) is a powerful, surface-specific vibrational probe ideally suited to studying buried interfaces; however, insight from theory is often necessary to explain the microscopic origins of the spectral features. To calculate the SFG spectrum at an insulating solid/liquid interface, we develop a flexible polarizability model that takes local dipole interactions into account, rather than assuming additive polarizabilities. We use this model to calculate bond dipoles and polarizabilities that reflect the local geometry of the interface...
April 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28368956/the-effect-of-varying-plyometric-volume-on-stretch-shortening-cycle-capability-in-collegiate-male-rugby-players
#13
Mark Jeffreys, Mark De Ste Croix, Rhodri S Lloyd, Jon L Oliver, Jonathan Hughes
The purpose of this study was to identify the effectiveness of low and high volume plyometric loads on developing stretch shortening cycle capability in collegiate rugby players. A between- group repeated measures design was used. Thirty six subjects (age 20.3 ±1.6 yrs, mass 91.63 ±10.36kg, stature 182.03 ±5.24cm) were randomly assigned to one of three groups, a control group (CG), a low volume plyometric group (LPG) or a high volume plyometric group (HPG). Data were collected from a force plate, and measures of reactive strength index (RSI) and leg stiffness were calculated from jump height, contact time and flight time...
March 25, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28329908/re-evaluating-the-roles-of-myosin-18a%C3%AE-and-f-actin-in-determining-golgi-morphology
#14
Kyle Bruun, Jordan R Beach, Sarah M Heissler, Kirsten Remmert, James R Sellers, John A Hammer
The peri-centrosomal localization and morphology of the Golgi apparatus depends largely on the microtubule cytoskeleton and the microtubule motor protein dynein. Recent studies proposed that myosin 18Aα (M18Aα) also contributes to Golgi morphology by binding the Golgi protein GOLPH3 and walking along adjacent actin filaments to stretch the Golgi into its classic ribbon structure. Biochemical analyses have shown, however, that M18A is not an actin-activated ATPase and lacks motor activity. Our goal, therefore, was to define the precise molecular mechanism by which M18Aα determines Golgi morphology...
March 22, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/28315975/spatial-patterns-and-frequency-distributions-of-regional-deformation-in-the-healthy-human-lung
#15
Daniel E Hurtado, Nicolás Villarroel, Carlos Andrade, Jaime Retamal, Guillermo Bugedo, Alejandro Bruhn
Understanding regional deformation in the lung has long attracted the medical community, as parenchymal deformation plays a key role in respiratory physiology. Recent advances in image registration make it possible to noninvasively study regional deformation, showing that volumetric deformation in healthy lungs follows complex spatial patterns not necessarily shared by all subjects, and that deformation can be highly anisotropic. In this work, we systematically study the regional deformation in the lungs of eleven human subjects by means of in vivo image-based biomechanical analysis...
March 18, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28288000/age-associated-chromatin-relaxation-is-enhanced-in-huntington-s-disease-mice
#16
Myungsun Park, Byungkuk Min, Kyuheum Jeon, Sunwha Cho, Jung Sun Park, Jisun Kim, Jeha Jeon, Jinhoi Song, Seokho Kim, Sangkyun Jeong, Hyemyung Seo, Yong-Kook Kang
Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PCRseq-based method to examine expression profile of 395 exonic segments from 260 "epi-driver" genes in splenic T lymphocytes from aged HD mice. We identified 67 exonic segments differentially expressed between young and aged HD mice, most of them upregulated in the aged...
March 12, 2017: Aging
https://www.readbyqxmd.com/read/28278518/the-actin-regulator-zyxin-reinforces-airway-smooth-muscle-and-accumulates-in-airways-of-fatal-asthmatics
#17
Sonia R Rosner, Christopher D Pascoe, Elizabeth Blankman, Christopher C Jensen, Ramaswamy Krishnan, Alan L James, John G Elliot, Francis H Green, Jeffrey C Liu, Chun Y Seow, Jin-Ah Park, Mary C Beckerle, Peter D Paré, Jeffrey J Fredberg, Mark A Smith
Bronchospasm induced in non-asthmatic human subjects can be easily reversed by a deep inspiration (DI) whereas bronchospasm that occurs spontaneously in asthmatic subjects cannot. This physiological effect of a DI has been attributed to the manner in which a DI causes airway smooth muscle (ASM) cells to stretch, but underlying molecular mechanisms-and their failure in asthma-remain obscure. Using cells and tissues from wild type and zyxin-/- mice we report responses to a transient stretch of physiologic magnitude and duration...
2017: PloS One
https://www.readbyqxmd.com/read/28273134/gene-set-meta-analysis-of-lung-cancer-identifies-pathway-related-to-systemic-lupus-erythematosus
#18
Albert Rosenberger, Melanie Sohns, Stefanie Friedrichs, Rayjean J Hung, Gord Fehringer, John McLaughlin, Christopher I Amos, Paul Brennan, Angela Risch, Irene Brüske, Neil E Caporaso, Maria Teresa Landi, David C Christiani, Yongyue Wei, Heike Bickeböller
INTRODUCTION: Gene-set analysis (GSA) is an approach using the results of single-marker genome-wide association studies when investigating pathways as a whole with respect to the genetic basis of a disease. METHODS: We performed a meta-analysis of seven GSAs for lung cancer, applying the method META-GSA. Overall, the information taken from 11,365 cases and 22,505 controls from within the TRICL/ILCCO consortia was used to investigate a total of 234 pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database...
2017: PloS One
https://www.readbyqxmd.com/read/28254749/expression-and-localization-of-pannexin-1-and-calhm1-in-porcine-bladder-and-their-involvement-in-modulating-atp-release
#19
Hafiz Sana-Ur-Rehman, Irit Markus, Kate Hilda Moore, Kylie Jan Mansfield, Lu Liu
ATP release from urinary bladder is vital for afferent signaling. The aims of this study were to localize CALHM1 and pannexin-1 expression and to determine their involvement in mediating ATP release in the bladder. Gene expression by PCR and immunohistochemistry were performed in the porcine bladder. CALHM1 and pannexin-1 mediated ATP release in response to hypotonic solution (0.45% NaCl) induced stretch and extracellular Ca(2+) depletion ([Ca(2+)]0) was measured in isolated urothelial, suburothelial and detrusor muscle cells...
March 2, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28217413/deformation-response-of-the-iliotibial-band-tensor-fascia-lata-complex-to-clinical-grade-longitudinal-tension-loading-in-vitro
#20
Mark Wilhelm, Omer Matthijs, Kevin Browne, Gesine Seeber, Anja Matthijs, Phillip S Sizer, Jean-Michel Brismée, C Roger James, Kerry K Gilbert
BACKGROUND: Iliotibial Band (ITB) syndrome is a troublesome condition with prevalence as high as 12% in runners. Stretching has been utilized as a conservative treatment. However, there is limited evidence supporting ITB elongation in response to a stretching force. PURPOSE/HYPOTHESES: The purpose of this study was to describe the iliotibial band tensor fascia lata complex (ITBTFLC) tissue elongation response to a simulated clinical stretch in-vitro. The authors hypothesized that the ITBTFLC would undergo statistically significant elongation when exposed to a clinical-grade stretching regimen, with the majority of the elongation occurring within the proximal ITBTFLC region...
February 2017: International Journal of Sports Physical Therapy
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