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https://www.readbyqxmd.com/read/29142095/patterns-of-intermuscular-inhibitory-force-feedback-across-cat-hindlimbs-suggest-a-flexible-system-for-regulating-whole-limb-mechanics
#1
Mark A Lyle, T Richard Nichols
Prior work has suggested that Golgi tendon organ feedback, via its distributed network linking muscles spanning all joints, could be used by the nervous system to help regulate whole limb mechanics if appropriately organized. We tested this hypothesis by characterizing the patterns of intermuscular force dependent feedback between the primary extensor muscles spanning the knee, ankle and toes in decerebrate cat hindlimbs. Intermuscular force feedback was evaluated by stretching tendons of selected muscles in isolation and in pairwise combinations and then measuring the resulting force dependent intermuscular interactions...
November 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29131295/the-intracardiac-concentrations-of-the-n-terminal-pro-b-type-natriuretic-peptide-nt-probnp-and-the-determinants-of-its-secretion-in-patients-with-atrial-fibrillation
#2
Witold Streb, Katarzyna Mitręga, Magdalena Szymała, Aleksandra Woźniak, Tomasz Podolecki, Zbigniew Kalarus
BACKGROUND: N-terminal-pro Brain Natriuretic Peptide (NT-proBNP) is elevated not only in heart failure (HF) but also in atrial fibrillation (AF). The role and secretion pattern of NT-proBNP in AF is still undetermined. AIM: The study aimed to assess NT-proBNP concentrations in patients with and without preserved left ventricular ejection fraction (LV-EF) depending on the type of AF. It was also intended to define the main source of NT-proBNP production within the heart...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29120006/manufactured-brace-modalities-for-elbow-stiffness
#3
Nipun Sodhi, Anton Khlopas, Michael D Vaughn, Jaiben George, George Yakubek, Assem A Sultan, Steven F Harwin, Michael A Mont
Multiple surgical and nonsurgical treatment options exist for patients with elbow stiffness. Many nonsurgical mobilization bracing options have been implemented to increase elbow range of motion. Three of the main bracing options for these patients are turnbuckle, static progressive stretch, and dynamic bracing. The purpose of this study was to review the current literature on turnbuckle, static progressive stretch, and dynamic bracing to provide information for practitioners and patients regarding which brace is more appropriate to use for elbow stiffness...
November 8, 2017: Orthopedics
https://www.readbyqxmd.com/read/29116102/epigenetic-transitions-and-knotted-solitons-in-stretched-chromatin
#4
D Michieletto, E Orlandini, D Marenduzzo
The spreading and regulation of epigenetic marks on chromosomes is crucial to establish and maintain cellular identity. Nonetheless, the dynamic mechanism leading to the establishment and maintenance of tissue-specific, epigenetic pattern is still poorly understood. In this work we propose, and investigate in silico, a possible experimental strategy to illuminate the interplay between 3D chromatin structure and epigenetic dynamics. We consider a set-up where a reconstituted chromatin fibre is stretched at its two ends (e...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29094366/observer-blind-randomized-controlled-study-of-a-cosmetic-blend-of-safflower-olive-and-other-plant-oils-in-the-improvement-of-scar-and-striae-appearance
#5
Stephan Bielfeldt, Jürgen Blaak, Rainer Wohlfart, Caroline Manger, Klaus-P Wilhelm
OBJECTIVE: The normal process of skin tissue repair following injury invariably results in visual scarring. It is known that topical treatment with hydrophobic cosmetics high in silicone and mineral oil content can improve the appearance of scars and striae. Given lifestyle preferences of many cosmetic consumers towards so-called natural treatments, the objective of this controlled randomized study was to investigate the efficacy of a plant body oil rich in oleic and linoleic acids (Bio Skin Oil(®) ) for improving the appearance of scars and striae...
November 2, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29082406/ergodicity-breaking-of-iron-displacement-in-heme-proteins
#6
Salman Seyedi, Dmitry V Matyushov
We present a model of the dynamical transition of atomic displacements in proteins. Increased mean-square displacement at higher temperatures is caused by the softening of the force constant for atomic/molecular displacements by electrostatic and van der Waals forces from the protein-water thermal bath. Displacement softening passes through a nonergodic dynamical transition when the relaxation time of the force-force correlation function enters, with increasing temperature, the instrumental observation window...
November 15, 2017: Soft Matter
https://www.readbyqxmd.com/read/29080694/castration-increases-pge2-release-from-the-bladder-epithelium-in-male-rats
#7
Hideaki Ito, Dong Wang, Xinmin Zha, So Inamura, Masaya Seki, Minekatsu Taga, Osamu Yokoyama
AIMS: Androgen deprivation therapy has been widely used for the treatment of prostate cancer. While sexual side effects including decreased sexual desire and function are well studied, there are only limited reports about its influences on lower urinary tract symptoms. The aim of this study is to clarify the influences of castration in male rats. METHODS: Ten-week-old male rats were divided into treatment group (bilateral orchiectomy) and control group (sham surgery)...
November 8, 2017: Life Sciences
https://www.readbyqxmd.com/read/29067382/extreme-halophilic-alcohol-dehydrogenase-mediated-highly-efficient-syntheses-of-enantiopure-aromatic-alcohols
#8
Diya Alsafadi, Safaa Alsalman, Francesca Paradisi
Enzymatic synthesis of enantiopure aromatic secondary alcohols (including substituted, hetero-aromatic and bicyclic structures) was carried out using halophilic alcohol dehydrogenase ADH2 from Haloferax volcanii (HvADH2). This enzyme showed an unprecedented substrate scope and absolute enatioselectivity. The cofactor NADPH was used catalytically and regenerated in situ by the biocatalyst, in the presence of 5% ethanol. The efficiency of HvADH2 for the conversion of aromatic ketones was markedly influenced by the steric and electronic factors as well as the solubility of ketones in the reaction medium...
November 7, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29062646/calcium-hydroxylapatite-combined-with-microneedling-and-ascorbic-acid-is-effective-for-treating-stretch-marks
#9
Gabriela Casabona, Paula Marchese
BACKGROUND: Stretch marks can have a negative psychological impact on some individuals. Methods are available for treating stretch marks, but high-quality evidence supporting their use is limited. We treat stretch marks using injections of diluted calcium hydroxylapatite (CaHA, Radiesse) filler combined with microneedling and topical ascorbic acid. This retrospective study evaluated the effectiveness of this combined therapy. METHODS: Subjects presented with red (n = 25) or white (n = 10) striae on their buttocks, thighs, knees, abdomen, and breasts...
September 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29057352/morphometric-anatomy-of-the-lumbar-sympathetic-trunk-with-respect-to-the-anterolateral-approach-to-lumbar-interbody-fusion-a-cadaver-study
#10
Gareth Rutter, Kevin Phan, Adam Smith, Fiona Stewart, Kevin Seex, Cristian Gragnaniello
BACKGROUND: An approach to lateral lumbar interbody fusion (LLIF) utilizing an oblique corridor anterior to the psoas muscle was first described by Mayer in 1997 and subsequently by other authors. The only consistent structure of note in this corridor is the lumbar sympathetic trunk (LST), which at times must be mobilized in order to perform a discectomy and interbody fusion, thereby placing the LST at risk. This study was designed to describe the morphometric anatomy of the LST in relation to surgically relevant landmarks for the anterolateral approach to the lumbar spine at L3/L4 to L5/S1...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29043794/dynamic-transition-from-%C3%AE-helices-to-%C3%AE-sheets-in-polypeptide-coiled-coil-motifs
#11
Kirill A Minin, Artem Zhmurov, Kenneth A Marx, Prashant K Purohit, Valeri Barsegov
We carried out dynamic force manipulations in silico on a variety of coiled-coil protein fragments from myosin, chemotaxis receptor, vimentin, fibrin, and phenylalanine zippers that vary in size and topology of their α-helical packing. When stretched along the superhelical axis, all superhelices show elastic, plastic, and inelastic elongation regimes and undergo a dynamic transition from the α-helices to the β-sheets, which marks the onset of plastic deformation. Using the Abeyaratne-Knowles formulation of phase transitions, we developed a new theoretical methodology to model mechanical and kinetic properties of protein coiled-coils under mechanical nonequilibrium conditions and to map out their energy landscapes...
November 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29037653/adolescent-idiopathic-scoliosis-the-tethered-spine-iii-is-fascial-spiral-the-key
#12
Lucy Whyte Ferguson
This article reports on an observational and treatment case series involving 22 adolescents and preadolescents treated over a 15 year period who had or appeared to be developing idiopathic scoliosis (IS). Common patterns of muscle and fascial asymmetry were observed and treated. Most of these individuals had spinal area pain and the trigger points (TrPs) apparently responsible for this pain were located in muscles at some distance from the spine, yet referred pain to locations throughout the thoracolumbar spine...
October 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29028987/in-silico-structural-modelling-of-multiple-epigenetic-marks-on-dna
#13
Konrad Krawczyk, Samuel Demharter, Bernhard Knapp, Charlotte M Deane, Peter Minary
Summary: There are four known epigenetic cytosine modifications in mammals: 5mC, 5hmC, 5fC and 5caC. The biological effects of 5mC are well understood but the roles of the remaining modifications remain elusive. Experimental and computational studies suggest that a single epigenetic mark has little structural effect but six of them can radically change the structure of DNA to a new form, F-DNA. Investigating the collective effect of multiple epigenetic marks requires the ability to interrogate all possible combinations of epigenetic states (e...
September 25, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028161/effect-of-haemodialysis-and-residual-renal-function-on-serum-levels-of-galectin-3-b-type-natriuretic-peptides-and-cardiac-troponin-t
#14
Matthew A Roberts, Piyush M Srivastava, David L Hare, Francesco L Ierino
AIM: Levels of plasma markers of myocardial fibrosis (galectin-3), stretch (B-type natriuretic peptide (BNP)) and injury (troponin T (TnT)) may be affected by haemodialysis and residual renal function (RRF) in addition to cardiac pathology. We aimed to determine the association of RRF, urine output and haemodialysis itself on clinically important cardiac biomarkers in haemodialysis patients. METHODS: Adult haemodialysis patients underwent venesection pre- and post- haemodialysis followed by echocardiography and inter-dialytic urine collection to calculate RRF (mL/minute/1...
October 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28974580/sumoylation-regulates-nuclear-accumulation-and-signaling-activity-of-the-soluble-intracellular-domain-of-the-erbb4-receptor-tyrosine-kinase
#15
Anna Maria Knittle, Maria Helkkula, Mark S Johnson, Maria Sundvall, Klaus Elenius
Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase-activated signaling cascades. Previously, we have demonstrated that ErbB4 ICD is posttranslationally modified by the small ubiquitin-like modifier (SUMO) and functionally interacts with the PIAS3 SUMO E3 ligase. However, direct evidence of SUMO modification in ErbB4 signaling has remained elusive. Here, we report that the conserved lysine residue 714 in the ErbB4 ICD undergoes SUMO modification, which was reversed by sentrin-specific proteases (SENPs) 1, 2 and 5...
October 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28951123/quantitative-multiphoton-microscopy-of-murine-urinary-bladder-morphology-during-in-situ-uniaxial-loading
#16
Jack Hornsby, Donna M Daly, David Grundy, Fangzhou Cheng, Anne M Robertson, Paul N Watton, Mark S Thompson
Urodynamic tests are the gold standard for the diagnosis of bladder dysfunction, and the mechanical compliance of the bladder is an important parameter in these tests. The bladder wall has a layered structure, differentially affected by pathology, so knowledge of the contribution and role of these layers and their constituents to overall bladder compliance will enhance interpretation of these clinical tests. In this study we document the functional morphology of the detrusor and lamina propria of the murine bladder wall using a custom in-situ tensile loading system under multiphoton microscopy (MPM) observation in unloaded state and under incremental uniaxial stretch...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28943709/a-machine-learning-framework-to-analyze-hyperspectral-stimulated-raman-scattering-microscopy-images-of-expressed-human-meibum
#17
Alba Alfonso-García, Jerry Paugh, Marjan Farid, Sumit Garg, James V Jester, Eric O Potma
We develop and discuss a methodology for batch-level analysis of hyperspectral stimulated Raman scattering (hsSRS) data sets of human meibum in the CH-stretching vibrational range. The analysis consists of two steps. The first step uses a training set (n=19) to determine chemically meaningful reference spectra that jointly constitute a basis set for the sample. This procedure makes use of batch-level vertex component analysis (VCA), followed by unsupervised k-means clustering to express the data set in terms of spectra that represent lipid and protein mixtures in changing proportions...
June 2017: Journal of Raman Spectroscopy: JRS
https://www.readbyqxmd.com/read/28943089/ehd-proteins-cooperate-to-generate-caveolar-clusters-and-to-maintain-caveolae-during-repeated-mechanical-stress
#18
Ivana Yeow, Gillian Howard, Jessica Chadwick, Carolina Mendoza-Topaz, Carsten G Hansen, Benjamin J Nichols, Elena Shvets
Caveolae introduce flask-shaped convolutions into the plasma membrane and help to protect the plasma membrane from damage under stretch forces. The protein components that form the bulb of caveolae are increasingly well characterized, but less is known about the contribution of proteins that localize to the constricted neck. Here we make extensive use of multiple CRISPR/Cas9-generated gene knockout and knockin cell lines to investigate the role of Eps15 Homology Domain (EHD) proteins at the neck of caveolae...
October 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28855791/impact-of-shoulder-internal-rotation-on-normal-sensory-response-during-ulnar-nerve-biased-neurodynamic-testing-of-asymptomatic-individuals
#19
Mark Gugliotti, Danielle Cohen, Angela Hernandez, Kristen Hinrichs, Nicole Osmundsen
OBJECTIVE: To determine if substitution of shoulder internal rotation for external rotation during the upper limb neurodynamic test (ULNT3) evokes comparable ulnar nerve sensory responses in asymptomatic individuals. METHODS: Range of motion, quality, quantity, and distribution of sensory responses in 50 asymptomatic individuals during the traditional ULNT3 were compared to identical measures during an experimental maneuver using shoulder internal rotation. Quality and quantity of sensory responses were recorded using a 10-cm visual analog scale...
February 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28855604/studying-the-role-of-fascin-1-in-mechanically-stressed-podocytes
#20
Felix Kliewe, Christian Scharf, Henrik Rogge, Katrin Darm, Maja T Lindenmeyer, Kerstin Amann, Clemens D Cohen, Karlhans Endlich, Nicole Endlich
Glomerular hypertension causes glomerulosclerosis via the loss of podocytes, which are challenged by increased mechanical load. We have demonstrated that podocytes are mechanosensitive. However, the response of podocytes to mechanical stretching remains incompletely understood. Here we demonstrate that the actin-bundling protein fascin-1 plays an important role in podocytes that are exposed to mechanical stress. Immunofluorescence staining revealed colocalization of fascin-1 and nephrin in mouse kidney sections...
August 30, 2017: Scientific Reports
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