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https://www.readbyqxmd.com/read/28855791/impact-of-shoulder-internal-rotation-on-normal-sensory-response-during-ulnar-nerve-biased-neurodynamic-testing-of-asymptomatic-individuals
#1
Mark Gugliotti, Danielle Cohen, Angela Hernandez, Kristen Hinrichs, Nicole Osmundsen
OBJECTIVE: To determine if substitution of shoulder internal rotation for external rotation during the upper limb neurodynamic test (ULNT3) evokes comparable ulnar nerve sensory responses in asymptomatic individuals. METHODS: Range of motion, quality, quantity, and distribution of sensory responses in 50 asymptomatic individuals during the traditional ULNT3 were compared to identical measures during an experimental maneuver using shoulder internal rotation. Quality and quantity of sensory responses were recorded using a 10-cm visual analog scale...
February 2017: Journal of Manual & Manipulative Therapy
https://www.readbyqxmd.com/read/28855604/studying-the-role-of-fascin-1-in-mechanically-stressed-podocytes
#2
Felix Kliewe, Christian Scharf, Henrik Rogge, Katrin Darm, Maja T Lindenmeyer, Kerstin Amann, Clemens D Cohen, Karlhans Endlich, Nicole Endlich
Glomerular hypertension causes glomerulosclerosis via the loss of podocytes, which are challenged by increased mechanical load. We have demonstrated that podocytes are mechanosensitive. However, the response of podocytes to mechanical stretching remains incompletely understood. Here we demonstrate that the actin-bundling protein fascin-1 plays an important role in podocytes that are exposed to mechanical stress. Immunofluorescence staining revealed colocalization of fascin-1 and nephrin in mouse kidney sections...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851860/a-qualitative-study-of-gp-nurse-and-practice-manager-views-on-using-targeted-case-finding-to-identify-patients-with-copd-in-primary-care
#3
Rachael H Summers, Taniya Sharmeen, Kate Lippiett, Kate Gillett, Carla Astles, Linh Vu, Mark Stafford-Watson, Anne Bruton, Mike Thomas, Tom Wilkinson
'Finding the missing millions' with chronic obstructive pulmonary disease became part of the Department of Health strategy for England in 2010. Targeted case-finding within primary care is one potential pro-active strategy, but currently little is known about the views of healthcare professionals on this approach. In this study, 36 healthcare professionals (12 GPs, 14 nurses, and 10 practice managers) from 34 UK practices participated in semi-structured telephone interviews about targeted case-finding. Interviews followed an interview guide, were audio-recorded, transcribed verbatim, coded and analysed using 'Framework Approach'...
August 29, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28831357/periauricular-keloids-on-face-lift-scars-in-a-patient-with-facial-nerve-paralysis
#4
Masayo Aoki, Satoshi Akaishi, Noriko M Matsumoto, Takuya Tsuge, Ken Kubomura, Midori Nishikawa, Shunichi Nomoto, Rei Ogawa
Keloids are caused by excessive scar formation that leads to scar growth beyond the initial scar boundaries. Keloid formation and progression is promoted by mechanical stress such as skin stretch force. Consequently, keloids rarely occur in paralyzed areas and areas with little skin tension, such as the periauricular region. Therefore, periauricular incision is commonly performed for face lifts. We report a rare case of keloids that arose from face-lift scars in a patient with bilateral facial nerve paralysis...
July 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28815554/severe-disruption-and-disorganization-of-dermal-collagen-fibrils-in-early-striae-gravidarum
#5
F Wang, K Calderone, T T Do, N R Smith, Y R Helfrich, T R B Johnson, S Kang, J J Voorhees, G J Fisher
BACKGROUND: Striae gravidarum (SG), or stretch marks of pregnancy, begin as erythematous streaks, and mature into hypopigmented atrophic bands. OBJECTIVES: To investigate molecular alterations that may promote atrophy of SG, we investigated dermal type I collagen fibrils, which provide human skin with support. METHODS: We obtained skin samples of recently developed, erythematous abdominal SG from pregnant women. To examine the organization of collagen fibrils, second-harmonic generation imaging was performed using multiphoton microscopy...
August 17, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28814791/molecular-dynamics-simulations-of-heterogeneous-cell-membranes-in-response-to-uniaxial-membrane-stretches-at-high-loading-rates
#6
Lili Zhang, Zesheng Zhang, John Jasa, Dongli Li, Robin O Cleveland, Mehrdad Negahban, Antoine Jérusalem
The chemobiomechanical signatures of diseased cells are often distinctively different from that of healthy cells. This mainly arises from cellular structural/compositional alterations induced by disease development or therapeutic molecules. Therapeutic shock waves have the potential to mechanically destroy diseased cells and/or increase cell membrane permeability for drug delivery. However, the biomolecular mechanisms by which shock waves interact with diseased and healthy cellular components remain largely unknown...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28801884/identification-and-partial-structural-characterization-of-mass-isolated-valsartan-and-its-metabolite-with-messenger-tagging-vibrational-spectroscopy
#7
Olga Gorlova, Sean M Colvin, Antonio Brathwaite, Fabian S Menges, Stephanie M Craig, Scott J Miller, Mark A Johnson
Recent advances in the coupling of vibrational spectroscopy with mass spectrometry create new opportunities for the structural characterization of metabolites with great sensitivity. Previous studies have demonstrated this scheme on 300 K ions using very high power free electron lasers in the fingerprint region of the infrared. Here we extend the scope of this approach to a single investigator scale as well as extend the spectral range to include the OH stretching fundamentals. This is accomplished by detecting the IR absorptions in a linear action regime by photodissociation of weakly bound N2 molecules, which are attached to the target ions in a cryogenically cooled, rf ion trap...
August 11, 2017: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/28754624/dynamics-of-dimeric-kinesins-limping-effect-of-longitudinal-force-effects-of-neck-linker-extension-and-mutation-and-comparison-between-kinesin-1-and-kinesin-2
#8
Si-Kao Guo, Peng-Ye Wang, Ping Xie
Conventional kinesin (kinesin-1) can walk on microtubule filaments in an asymmetric hand-over-hand manner, exhibiting a marked alternation in the mean dwell time in successive steps. Here, we study computationally the asymmetric stepping dynamics of the kinesin-1 homodimer, revealing its origin and providing quantitative explanations of the available experimental data. The alternation in the mean dwell time in successive steps arises from the alternation in the mechanochemical coupling ratio, which is in turn caused by the alternation in the slight variation of the stretched neck linker length...
July 25, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28754452/an-abnormal-trpv4-related-cytosolic-ca-2-rise-in-response-to-uniaxial-stretch-in-induced-pluripotent-stem-cells-derived-cardiomyocytes-from-dilated-cardiomyopathy-patients
#9
Jun Lu, Yee-Ki Lee, Xinru Ran, Wing-Hon Lai, Ronald A Li, Wendy Keung, Kennis Tse, Hung-Fat Tse, Xiaoqiang Yao
Dilated cardiomyopathy (DCM) is cardiac disease characterized by increased left ventricular chamber volume and decreased systolic function. DCM patient-specific human induced-pluripotent stem cells-derived cardiomyocytes (DCM-hiPSC-CMs) were generated. We found that uniaxial stretch elicited a cytosolic [Ca(2+)]i rise in hiPSC-CMs. Compared to control-hiPSC-CMs, DCM-hiPSC-CMs displayed a greater magnitude of [Ca(2+)]i responses to the cell stretch of 10-15% elongation in length. This stretch-induced [Ca(2+)]i rise was abolished by removal of extracellular Ca(2+) and markedly attenuated by TRPV4 inhibitors HC-067047 and RN-1734...
July 25, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28749842/reconstruction-of-large-postburn-facial-scalp-scars-by-expanded-pedicled-deltopectoral-flap-and-random-scalp-flap-technique-improvements-to-enlarge-the-reconstructive-territory
#10
Xianjie Ma, Yang Li, Weiyang Li, Chaohua Liu, Pai Peng, Baoqiang Song, Wensen Xia, Chenggang Yi, Kaihua Lu, Yingjun Su
The scars of face and scalp caused by burning often show as 1 large facial-scalp scar. The deltopectoral flap was recognized as one of the first choices for the facial scar reconstruction. However, this flap cannot cross the level of zygomatic arch traditionally when it was transferred with pedicle. When the flap reconstructed the facial-scalp scars with expanded random scalp flap, another flap was often needed to reconstruct the remaining temple and forehead scars. The authors reviewed 24 patients of large facial-scalp scars reconstructed by expanded pedicled deltopectoral flap and scalp flap with several technique improvements...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28731051/neurotropic-melanoma-an-analysis-of-the-clinicopathological-features-management-strategies-and-survival-outcomes-for-671-patients-treated-at-a-tertiary-referral-center
#11
Alexander H R Varey, Chris Goumas, Angela M Hong, Graham J Mann, Gerald B Fogarty, Jonathan R Stretch, Robyn P M Saw, Andrew J Spillane, Kerwin F Shannon, Kenneth J Lee, Michael J Quinn, John F Thompson, Richard A Scolyer
Neurotropic cutaneous melanoma is a rare melanoma subtype that invades nerves and is often associated with desmoplastic melanoma. Limited data suggest that it has a greater propensity to recur locally, but it is unknown whether its behavior differs from that of other melanoma subtypes, including desmoplastic melanoma. We investigated clinicopathological predictors of outcome in a cohort of 671 patients with neurotropic melanoma to develop evidence-based management recommendations. Patients with primary neurotropic melanoma diagnosed from 1985 to 2013 were identified from the Melanoma Institute Australia database, along with a control cohort of 718 non-neurotropic melanoma patients...
July 21, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28728817/piezo2-in-cutaneous-and-proprioceptive-mechanotransduction-in-vertebrates
#12
E O Anderson, E R Schneider, S N Bagriantsev
Mechanosensitivity is a fundamental physiological capacity, which pertains to all life forms. Progress has been made with regard to understanding mechanosensitivity in bacteria, flies, and worms. In vertebrates, however, the molecular identity of mechanotransducers in somatic and neuronal cells has only started to appear. The Piezo family of mechanogated ion channels marks a pivotal milestone in understanding mechanosensitivity. Piezo1 and Piezo2 have now been shown to participate in a number of processes, ranging from arterial modeling to sensing muscle stretch...
2017: Current Topics in Membranes
https://www.readbyqxmd.com/read/28723241/the-effects-of-stretch-activation-on-ionic-selectivity-of-the-trek-2-k2p-k-channel
#13
Ehsan Nematian-Ardestani, Viwan Jarerattanachat, Prafulla Aryal, Mark S P Sansom, Stephen J Tucker
The TREK-2 (KCNK10) K2P potassium channel can be regulated by variety of polymodal stimuli including pressure. In a recent study, we demonstrated that this mechanosensitive K(+) channel responds to changes in membrane tension by undergoing a major structural change from its 'down' state to the more expanded 'up' state conformation. These changes are mostly restricted to the lower part of the protein within the bilayer, but are allosterically coupled to the primary gating mechanism located within the selectivity filter...
July 19, 2017: Channels
https://www.readbyqxmd.com/read/28718090/a-large-retroperitoneal-lymphatic-malformation-successfully-treated-with-traditional-japanese-kampo-medicine-in-combination-with-surgery
#14
Toko Shinkai, Kouji Masumoto, Fumiko Chiba, Nao Tanaka
BACKGROUND: Current treatment options for lymphatic malformations (LMs) are multimodal. Recently, the effectiveness of treating LMs with Eppikajyutsuto (TJ-28) has been reported. TJ-28 is a kind of oral herbal medicine classified as the traditional Japanese Kampo medicine. CASE PRESENTATION: A 12-year-old girl was admitted to our hospital for intermittent upper abdominal pain. Radiological examinations revealed a large (9.5 × 5.8 × 10.0 cm) retroperitoneal LM, which was suspected to adhering and stretching both pancreas head and duodenum...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28716516/hypertonia
#15
Sarah Helen Evans, Mark William Cameron, Justin Michael Burton
Hypertonia is the abnormal increase in muscle tone as a result of upper motor neuron lesions. There are three following clinical types: spasticity, dystonia, and rigidity. Management of hypertonia is individualized and should be directed by the patient and/or family׳s goals of care as well as the underlying cause of the hypertonia. Treatment options include stretching, strengthening, positioning, oral medications, botulinum toxin injections, phenol injections, as well as surgical procedures. Without effective management, hypertonia can result in muscle imbalance, abnormal movement patterns, pain, joint contracture, joint deformity, and ultimately negatively impact a patient׳s function...
July 14, 2017: Current Problems in Pediatric and Adolescent Health Care
https://www.readbyqxmd.com/read/28708657/reconstruction-of-facial-cervical-scars-with-pedicled-expanded-deltopectoral-flap
#16
Xianjie Ma, Yang Li, Weiyang Li, Chaohua Liu, Hengxin Liu, Ping Xue, Jiangbo Cui
The facial-cervical scars bring the suffering to the patients both physically and mentally. Choosing a proper donor soft tissue is always one of the critical issues, especially to Asian patients. Among the common used donor sites, the deltopectoral site was conceived as the most suitable donor tissue for the reconstruction in face and neck for its adjacent site and match in color and texture. There were 220 patients with facial-cervical scars reconstructed by the pedicled expanded deltopectoral flap between 2007 through 2015 in the authors' hospital...
September 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28708441/safe-monsplasty-technique
#17
Audrey Patoué, Antoine De Runz, Raphael Carloni, Sylvie Aillet, Eric Watier, Nicolas Bertheuil
INTRODUCTION: To improve their health and quality of life, obese patients undergo consultation after weight loss. In these patients, the sub-umbilical abdominal and pubic regions are often characterized by redundant skin, creating aesthetic and functional discomfort. Monsplasty is an important step in abdominoplasty or bodylift procedures. We report on an original technique used to correct deformity in the pubic region following weight loss. METHODS: All interventions were performed by the same surgeon between April and December 2015...
July 14, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28689239/structure-function-relationship-of-the-human-external-anal-sphincter
#18
Amanda M Stewart, Mark S Cook, Keisha Y Dyer, Marianna Alperin
INTRODUCTION AND HYPOTHESIS: Obstetrical external anal sphincter (EAS) injury and subsequent dysfunction are leading risk factors for female fecal incontinence (FI). Limited knowledge of the EAS structure-function relationship hinders treatment optimization. We directly measured functionally relevant intrinsic parameters of human EAS and tested whether vaginal delivery alters the EAS structure-function relationship. METHODS: Major predictors of in vivo EAS function were compared between specimens procured from vaginally nulliparous (VN, n = 5) and vaginally parous (VP, n = 7) cadaveric donors: operational sarcomere length (Ls), which dictates force-length relationship; physiological cross-sectional area (PCSA), which determines isometric force-generating capacity; fiber length (Lfn), responsible for muscle excursion and contractile velocity; and muscle stiffness...
July 8, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28673025/alignment-free-inference-of-hierarchical-and-reticulate-phylogenomic-relationships
#19
Guillaume Bernard, Cheong Xin Chan, Yao-Ban Chan, Xin-Yi Chua, Yingnan Cong, James M Hogan, Stefan R Maetschke, Mark A Ragan
We are amidst an ongoing flood of sequence data arising from the application of high-throughput technologies, and a concomitant fundamental revision in our understanding of how genomes evolve individually and within the biosphere. Workflows for phylogenomic inference must accommodate data that are not only much larger than before, but often more error prone and perhaps misassembled, or not assembled in the first place. Moreover, genomes of microbes, viruses and plasmids evolve not only by tree-like descent with modification but also by incorporating stretches of exogenous DNA...
June 30, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/28667588/post-injury-stretch-promotes-recovery-in-a-rat-model-of-muscle-damage-induced-by-lengthening-contractions
#20
Tomohiro Mori, Nobuhide Agata, Yuta Itoh, Masumi Inoue-Miyazu, Kazue Mizumura, Masahiro Sokabe, Toru Taguchi, Keisuke Kawakami
We investigated the cellular mechanisms and therapeutic effect of post-injury stretch on the recovery process from muscle injury induced by lengthening contractions (LC). One day after LC, a single 15-min bout of muscle stretch was applied at an intensity of 3 mNm. The maximal isometric torque was measured before and at 2-21 days after LC. The myofiber size was analyzed at 21 days after LC. Developmental myosin heavy chain-immunoreactive (dMHC-ir) cells, a marker of regenerating myofibers, were observed in the early recovery stage (2-5 days after LC)...
June 30, 2017: Journal of Physiological Sciences: JPS
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