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https://www.readbyqxmd.com/read/28630259/triacylglycerol-mimetics-regulate-membrane-interactions-of-glycogen-branching-enzyme-implications-for-therapy
#1
Rafael Alvarez, Jesús Casas, David J López, Maitane Ibarguren, Ariadna Suari-Rivera, Silvia Terés, Francisca Guardiola-Serrano, Alexander Lossos, Xavier Busquets, Or Kakhlon, Pablo V Escribá
Adult Polyglucosan Body Disease (APBD) is a neurological disorder characterized by adult-onset neurogenic bladder, spasticity, weakness, and sensory loss. The disease is caused by aberrant glycogen branching enzyme (GBE1-Y329S) yielding less branched, globular and soluble glycogen which tends to aggregate. We explore here whether, despite being a soluble enzyme, GBE1 activity is regulated by protein-membrane interactions. Since soluble proteins can contact a wide variety of cell membranes, we investigated the interactions of purified wild-type and Y329S GBE1 proteins with different types of model membranes (liposomes)...
June 19, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28628233/spatial-and-temporal-trends-of-poly-and-perfluoroalkyl-substances-in-fish-fillets-and-water-collected-from-pool-2-of-the-upper-mississippi-river
#2
John L Newsted, Ryan Holem, Cleston Lange, Mark Ellefson, Gary Hohenstein, William Reagen, Susan Wolf
In 2011, poly- and perfluoroalkyl substances (PFASs) were analyzed in surface water and fish fillet samples taken from Pool 2 of the Upper Mississippi River, a 33-mile stretch inclusive of the Minneapolis/St. Paul, Minnesota metropolitan area. Approximately 100 each of bluegill (BGS), freshwater drum (FWD), smallmouth bass (SMB), and white bass (WHB) were sampled within the study area. Surface water samples were also collected from each of the 10 sampling reaches established for the study. Water and fillet samples were analyzed for perfluorinated carboxylic acids (PFCAs) (C4-C12), perfluorinated sulfonic acids (PFSAs) (C4, C6, and C8), and perfluorooctane sulfonamide (FOSA)...
June 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28612401/safety-and-effectiveness-of-collagenase-clostridium-histolyticum-cch-xiapex-%C3%A2-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#3
Amr Abdel Raheem, Marco Capece, Odunayo Kalejaiye, Tarek Abdel-Raheem, Marco Falcone, Mark Johnson, Oliver George Ralph, Giulio Garaffa, Andrew Nim Christopher, David John Ralph
OBJECTIVES: To evaluate the efficacy and safety of collagenase clostridium histolyticum (CCH) (Xiapex(®) , Xiaflex(®) ) in the treatment of Peyronie's disease (PD) using a new modified treatment protocol which aims at reducing the number of injections needed and reducing patient visits, thus reducing the cost and duration of treatment. PATIENTS AND METHODS: A prospective study of 53 patients with PD who had treatment with CCH at a single center using a new modified protocol...
June 14, 2017: BJU International
https://www.readbyqxmd.com/read/28593188/barrett-s-stem-cells-as-a-unique-and-targetable%C3%A2-entity
#4
Wa Xian, Frank McKeon
Although metaplasias have always attracted because of their strangeness, it is now clear they represent precursors for some of the most intractable human cancers. Despite this notoriety, they remain curiously understudied, and even their origins have been the subject of acrimonious debate stretching back to Virchow in the 19th century. Barrett's esophagus, with its high incidence, easy endoscopic access, and strong link to esophageal adenocarcinoma, would seem an ideal opportunity to address the origin problem...
July 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28566495/hidden-role-of-intermolecular-proton-transfer-in-the-anomalously-diffuse-vibrational-spectrum-of-a-trapped-hydronium-ion
#5
Stephanie M Craig, Fabian S Menges, Chinh H Duong, Joanna K Denton, Lindsey R Madison, Anne B McCoy, Mark A Johnson
We report the vibrational spectra of the hydronium and methyl-ammonium ions captured in the C3v binding pocket of the 18-crown-6 ether ionophore. Although the NH stretching bands of the CH3NH3(+) ion are consistent with harmonic expectations, the OH stretching bands of H3O(+) are surprisingly broad, appearing as a diffuse background absorption with little intensity modulation over 800 cm(-1) with an onset ∼400 cm(-1) below the harmonic prediction. This structure persists even when only a single OH group is present in the HD2O(+) isotopologue, while the OD stretching region displays a regular progression involving a soft mode at about 85 cm(-1) These results are rationalized in a vibrationally adiabatic (VA) model in which the motion of the H3O(+) ion in the crown pocket is strongly coupled with its OH stretches...
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28560300/striae-gravidarum-risk-factors-prevention-and-management
#6
REVIEW
B Farahnik, K Park, G Kroumpouzos, J Murase
BACKGROUND: Striae gravidarum (SG) are atrophic linear scars that represent one of the most common connective tissue changes during pregnancy. SG can cause emotional and psychological distress for many women. Research on risk factors, prevention, and management of SG has been often inconclusive. METHODS: We conducted a literature search using textbooks, PubMed, and Medline databases to assess research performed on the risk factors, prevention, and management of SG...
June 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28532932/intereye-comparison-of-femtosecond-laser-assisted-cataract-surgery-capsulotomy-and-manual-capsulorhexis-edge%C3%A2-strength
#7
Thomas Chan, Ushasree Pattamatta, Mark Butlin, Kerrie Meades, Chandra Bala
PURPOSE: To compare the breaking force required to tear the explanted capsule after femtosecond laser-assisted cataract surgery in the worse eye and manual cataract surgery in the contralateral eye. SETTING: Personaleyes, Sydney, Australia. DESIGN: Prospective nonrandomized case study. METHOD: Patients with bilateral cataract had femtosecond laser-assisted cataract surgery with the Lensx laser in the eye with worse vision and manual cataract surgery in the contralateral eye...
April 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28530836/nuclear-quantum-effects-in-water-reorientation-and-hydrogen-bond-dynamics
#8
David M Wilkins, David E Manolopoulos, Silvio Pipolo, Damien Laage, James T Hynes
We combine classical and ring polymer molecular dynamics simulations with the molecular jump model to provide a molecular description of the nuclear quantum effects (NQEs) on water reorientation and hydrogen-bond dynamics in liquid H2O and D2O. We show that while the net NQE is negligible in D2O, it leads to a ∼13% acceleration in H2O dynamics compared to a classical description. Large angular jumps-exchanging hydrogen-bond partners-are the dominant reorientation pathway (just as in a classical description); the faster reorientation dynamics arise from the increased jump rate constant...
June 15, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28527353/mechanical-behavior-of-the-abdominal-aortic-aneurysm-assessed-by-biaxial-tests-in-the-rat-xenograft-model
#9
Louise Marais, Mustapha Zidi
This paper addresses the mechanical biaxial behavior of degraded arteries obtained by the rat xenograft model. For that, a pressure myograph was used to perform extension-inflation tests on abdominal aortic aneurysms (AAAs). Furthermore, residual stresses in the aneurismal wall were assessed by opening angle tests. Thus, the changes in mechanical behavior between native murine aortas, decellularized guinea pig aortas (the grafts) and degraded aortas (AAAs) were investigated. It was shown that decellularized and degraded aortas exhibited a different mechanical behavior than native murine aortas...
May 12, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28525483/development-of-a-remodeled-caspar-retractor-and-its-application-in-the-measurement-of-distractive-resistance-in-an-in-vitro-anterior-cervical-distraction-model
#10
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of the cervical intervertebral distraction using a remodeled Caspar retractor. OBJECTIVE: To investigate the torques required for distraction to different heights in an in vitro C3-C4 anterior cervical distraction model using a remodeled Caspar retractor, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the torques required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525470/factors-affecting-the-nonlinear-force-versus-distraction-height-curves-in-an-in-vitro-c5-c6-anterior-cervical-distraction-model
#11
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of cervical intervertebral distraction. OBJECTIVE: To investigate the forces required for distraction to different heights in an in vitro C5-C6 anterior cervical distraction model, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the forces required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28521090/ultrafast-vibrational-energy-transfer-in-catalytic-monolayers-at-solid-liquid-interfaces
#12
Jan Philip Kraack, Angelo Frei, Roger Alberto, Peter Hamm
We investigate the ultrafast vibrational dynamics of monolayers from adsorbed rhenium-carbonyl CO2-reduction catalysts on a semiconductor surface (indium-tin-oxide (ITO)) with ultrafast two-dimensional attenuated total reflection infrared (2D ATR IR) spectroscopy. The complexes are partially equipped with isotope-labeled ((13)C) carbonyl ligands to generate two spectroscopically distinguishable forms of the molecules. Ultrafast vibrational energy transfer between the molecules is observed via the temporal evolution of cross-peaks between their symmetric carbonyl stretching vibrations...
May 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28500662/application-of-a-novel-bioreactor-for-in-vivo-engineering-of-pancreas-tissue
#13
Javad Hashemi, Parvin Pasalar, Masoud Soleimani, Reza Khorramirouz, Kiarad Fendereski, Seyed Ehsan Enderami, Abdol-Mohammad Kajbafzadeh
Type 1 diabetes is characterized by autoimmune destruction of pancreatic cells. Organ transplantation is an acceptable treatment for native organ failure. However, it is associated with several problems due to a number of reasons, such as the lack of appropriate donors and immunosuppression. In our present study, a novel model is presented for in vivo recellularization of acellular pancreas by implanting between the host pancreas and the adjacent omental flap. In this study, the pancreases were harvested and cannulated via the common bile duct and then, the scaffolds were acellularized by a detergent-based protocol...
May 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28494267/advanced-glycation-products-levels-and-mechanical-properties-of-vaginal-tissue-in-pregnancy
#14
Homayemem K Weli, Riaz Akhtar, Zhuo Chang, Wen-Wu Li, Jason Cooper, Ying Yang
OBJECTIVES: Non-enzymatic glycation is closely associated with altered mechanical properties of connective tissue. Pregnancy, marked with high levels of female hormones, confers unique alteration to the mechanical properties of pelvic connective tissues in order to meet their physiological demands. However, there are few studies on glycation content and its influence on the mechanical properties of pelvic connective tissues during pregnancy. We hypothesise that the glycation content in pelvic tissues will change with a corresponding alteration in their mechanical properties, and that these changes are influenced by hormone levels...
April 23, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28490320/astaxanthin-protects-astrocytes-against-trauma-induced-apoptosis-through-inhibition-of-nkcc1-expression-via-the-nf-%C3%AE%C2%BAb-signaling-pathway
#15
Mingkun Zhang, Zhenwen Cui, Hua Cui, Yong Wang, Chunlong Zhong
BACKGROUND: Astaxanthin (ATX) is a carotenoid pigment with pleiotropic pharmacological properties that is seen as a possible drug for treating cerebral ischemic injury and subarachnoid hemorrhage. Na(+)-K(+)-2Cl(-) co-transporter-1 (NKCC1), an intrinsic membrane protein expressed by many cell types, is activated by various insults, leading to the formation of cell swelling and brain edema. We previously established that ATX attenuated brain edema and improved neurological outcomes by modulating NKCC1 expression after traumatic brain injury in mice...
May 10, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28482579/tio2-nanorod-arrays-modified-ti-substrates-promote-the-adhesion-proliferation-and-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells
#16
Zhi Li, Jichuan Qiu, Ling Qian Du, Lu Jia, Hong Liu, Shaohua Ge
Nanostructure coating on titanium (Ti) implants is well known as a cue for directing osteoblast behavior and function. However, effects of nanostructure coatings on dental stem cells have been rarely explored. In this work, assembled TiO2 nanorod arrays (TNRs) were fabricated on the polished Ti substrates using hydrothermal and sintering methods. The adhesion, morphology, proliferation and osteogenic differentiation of human periodontal ligament stem cells (PDLSCs) seeded onto TNRs substrates were evaluated...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481639/ct-measure-of-lung-at-risk-and-lung-function-decline-in-chronic-obstructive-pulmonary-disease
#17
Surya P Bhatt, Sandeep Bodduluri, Eric A Hoffman, John D Newell, Jessica C Sieren, Mark T Dransfield, Joseph M Reinhardt
RATIONALE: The rate of decline of lung function is greater than age-related change in a substantial proportion of patients with COPD, even after smoking cessation. Regions of the lung adjacent to emphysematous areas are subject to abnormal stretch during respiration, and this biomechanical stress likely influences emphysema initiation and progression. OBJECTIVE: To assess whether quantifying this penumbra of lung-at-risk would predict FEV1 decline. METHODS: We analyzed paired inspiratory-expiratory computerized tomography (CT) images at baseline of 680 subjects participating in a large multicenter study (COPDGene) over approximately 5 years...
May 8, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28479025/a-case-report-on-the-use-of-vibration-to-improve-soft-tissue-extensibility-after-major-trauma
#18
Mark Paul Brewin, Carole J Bexon, Sarah C Tucker
This report presents a case where vibration training to the arm alone, as opposed to whole-body vibration, was used to aid rehabilitation to a serious traumatic injury. An improvement in soft tissue extensibility to a major traumatic wound to the wrist and forearm has been noted in a therapy plan including vibration under stretch. After 12 weeks of intensive therapy, a considerable improvement was seen in both the active extension of the wrist and the composite extension of all fingers. This may highlight the use of vibration, as an adjunct to therapy, to specific areas of the human body for improving outcome from traumatic injury...
May 4, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28472894/resting-energy-expenditure-in-male-athletes-with-a-spinal-cord-injury
#19
Fiona E Pelly, Elizabeth M Broad, Natalie Stuart, Mark A Holmes
OBJECTIVE: To investigate whether there are differences in the resting energy expenditure (REE) and body composition of athletes with a spinal cord injury (SCI) compared to active able-bodied controls. DESIGN: In this cross sectional study, male athletes with a SCI were compared to active able-bodied controls matched for age, stretch stature and body mass. In addition, the accuracy of standard REE prediction equations in estimating REE was assessed. PARTICIPANTS: Seven male wheelchair athletes with a SCI and six matched active able-bodied controls volunteered to participate...
May 4, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28469177/early-signs-of-architectural-and-biomechanical-failure-in-isolated-myofibers-and-immortalized-myoblasts-from-desmin-mutant-knock-in-mice
#20
Stefanie Diermeier, Julian Iberl, Kristina Vetter, Michael Haug, Charlotte Pollmann, Barbara Reischl, Andreas Buttgereit, Sebastian Schürmann, Marina Spörrer, Wolfgang H Goldmann, Ben Fabry, Fatiha Elhamine, Robert Stehle, Gabriele Pfitzer, Lilli Winter, Christoph S Clemen, Harald Herrmann, Rolf Schröder, Oliver Friedrich
In striated muscle, desmin intermediate filaments interlink the contractile myofibrillar apparatus with mitochondria, nuclei, and the sarcolemma. The desmin network's pivotal role in myocytes is evident since mutations in the human desmin gene cause severe myopathies and cardiomyopathies. Here, we investigated skeletal muscle pathology in myofibers and myofibrils isolated from young hetero- and homozygous R349P desmin knock-in mice, which carry the orthologue of the most frequent human desmin missense mutation R350P...
May 3, 2017: Scientific Reports
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