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https://www.readbyqxmd.com/read/27911784/%C3%AE-arrestin-mediates-the-frank-starling-mechanism-of-cardiac-contractility
#1
Dennis M Abraham, Robert T Davis, Chad M Warren, Lan Mao, Beata M Wolska, R John Solaro, Howard A Rockman
The Frank-Starling law of the heart is a physiological phenomenon that describes an intrinsic property of heart muscle in which increased cardiac filling leads to enhanced cardiac contractility. Identified more than a century ago, the Frank-Starling relationship is currently known to involve length-dependent enhancement of cardiac myofilament Ca(2+) sensitivity. However, the upstream molecular events that link cellular stretch to the length-dependent myofilament Ca(2+) sensitivity are poorly understood. Because the angiotensin II type 1 receptor (AT1R) and the multifunctional transducer protein β-arrestin have been shown to mediate mechanosensitive cellular signaling, we tested the hypothesis that these two proteins are involved in the Frank-Starling mechanism of the heart...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27901341/the-efficacy-and-characteristics-of-warm-up-and-re-warm-up-practices-in-soccer-players-a-systematic-review
#2
Amri Hammami, James Zois, Maamer Slimani, Mark Russel, Ezdine Bouhlel
INTRODUCTION: This review aimed (i) to evaluate the current research that examines the efficacy of warm-up (WU) and re-warm-up (RWU) on physical performance, and (ii) to highlight the WU and RWU characteristics that optimise subsequent performance in soccer players. EVIDENCE ACQUISITION: A computerized search was performed in the PubMed, ScienceDirect and Google Scholar (from 1995 to December 2015) for English-language, peer- reviewed investigations using the terms "soccer" OR "football" AND "warm-up" OR "stretching" OR "post-activation potentiation" OR "pre-activity" OR "re-warm-up" AND "performance" OR "jump" OR "sprint" OR "running"...
November 30, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27893065/histology-and-biaxial-mechanical-behavior-of-abdominal-aortic-aneurysm-tissue-samples
#3
Francesco Q Pancheri, Robert A Peattie, Nithin D Reddy, Touhid Ahamed, Wenjian Lin, Timothy D Ouellette, Mark D Iafrati, A Luis Dorfmann
Abdominal aortic aneurysms (AAA) represent permanent, localized dilations of the abdominal aorta that can be life-threatening if progressing to rupture. Evaluation of risk of rupture depends on understanding the mechanical behavior of patient AAA walls. In this project, a series of patient AAA wall tissue samples have been evaluated through a combined anamnestic, mechanical and histopathologic approach. Mechanical properties of the samples have been characterized using a novel, strain-controlled, planar biaxial testing protocol emulating the in vivo deformation of the aorta...
November 18, 2016: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/27890575/3d-hybrid-modelling-of-vascular-network-formation
#4
Holger Perfahl, Barry D Hughes, Tomás Alarcón, Philip K Maini, Mark C Lloyd, Matthias Reuss, Helen M Byrne
We develop an off-lattice, agent-based model to describe vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells during development. The endothelial cells that comprise our vessel network are viewed as linearly elastic spheres that move in response to the forces they experience. We distinguish two types of endothelial cells: vessel elements are contained within the network and tip cells are located at the ends of vessels. Tip cells move in response to mechanical forces caused by interactions with neighbouring vessel elements and the local tissue environment, chemotactic forces and a persistence force which accounts for their tendency to continue moving in the same direction...
November 24, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27863277/vitamin-d-supplementation-affects-the-igf-system-in-men-after-acute-exercise
#5
Rachel L Darr, Kathleen J Savage, Mark Baker, Gregory E Wilding, Amy Raswalsky, Todd Rideout, Richard W Browne, Peter J Horvath
OBJECTIVE: Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system. DESIGN: D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit...
November 5, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27862699/microrna-503-5p-inhibits-stretch-induced-osteogenic-differentiation-and-bone-formation
#6
Lu Liu, Mengjun Liu, Rongrong Li, Hong Liu, Liling Du, Hong Chen, Yan Zhang, Shijie Zhang, Dongxu Liu
Cyclical stretch-induced bone formation during orthodontic treatment is a complex biological process modulated by various factors including miRNAs and their targeted-gene network. However, the miRNA expression profile and their roles in osteogenic differentiation of bone mesenchymal stem cells (BMSCs) exposed to mechanical stretch remains unclear. Here, we use the miRNA microarray assay to screen for mechano-sensitive miRNAs during stretch-induced osteogenic differentiation of BMSCs and identified that nine miRNAs were differentially expressed between stretched and control BMSCs...
November 11, 2016: Cell Biology International
https://www.readbyqxmd.com/read/27858240/return-of-motor-evoked-potentials-after-knee-flexion-in-the-setting-of-high-grade-spondylolisthesis
#7
Justin Tilan, Lindsay M Andras, Mark D Krieger, David L Skaggs
PURPOSE: To present a case of loss of motor-evoked potentials (MEPs) to the left foot in the supine position after a partial reduction and instrumented fusion from L4 to pelvis which was managed successfully without revision or removal of implants. METHODS: We report a patient with high-grade spondylolisthesis who demonstrated loss of motor-evoked potentials after posterior spinal fusion and transfer to supine position. The patient's knees were flexed to 90° and signals were immediately restored...
November 17, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27856308/dysregulation-of-hyaluronan-homeostasis-during-aortic-valve-disease
#8
Varun K Krishnamurthy, Andrew J Stout, Matthew C Sapp, Brittany Matuska, Mark E Lauer, K Jane Grande-Allen
Aortic valve disease (AVD) is one of the leading causes of cardiovascular mortality. Abnormal expression of hyaluronan (HA) and its synthesizing/degrading enzymes have been observed during latent AVD however, the mechanism of impaired hyaluronan homeostasis prior to and after the onset of AVD remains unexplored. Transforming growth factor beta (TGFβ) pathway defects and biomechanical dysfunction are hallmarks of AVD, however their association with altered hyaluronan regulation is understudied. Expression of HA homeostatic markers was evaluated in diseased human aortic valves and TGFβ1-cultured porcine aortic valve tissues using histology, immunohistochemistry and Western blotting...
November 14, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27849028/evidences-for-cooperative-resonance-assisted-hydrogen-bonds-in-protein-secondary-structure-analogs
#9
Yu Zhou, Geng Deng, Yan-Zhen Zheng, Jing Xu, Hamad Ashraf, Zhi-Wu Yu
Cooperative behaviors of the hydrogen bonding networks in proteins have been discovered for a long time. The structural origin of this cooperativity, however, is still under debate. Here we report a new investigation combining excess infrared spectroscopy and density functional theory calculation on peptide analogs, represented by N-methylformamide (NMF) and N-methylacetamide (NMA). Interestingly, addition of the strong hydrogen bond acceptor, dimethyl sulfoxide, to the pure analogs caused opposite effects, namely red- and blue-shift of the N-H stretching infrared absorption in NMF and NMA, respectively...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27812420/widespread-dieback-of-riparian-trees-on-a-dammed-ephemeral-river-and-evidence-of-local-mitigation-by-tributary-flows
#10
Caitlin M S Douglas, Mark Mulligan, Xavier A Harrison, Joh R Henschel, Nathalie Pettorelli, Guy Cowlishaw
Ephemeral rivers act as linear oases in drylands providing key resources to people and wildlife. However, not much is known about these rivers' sensitivities to human activities. We investigated the landscape-level determinants of riparian tree dieback along the Swakop River, a dammed ephemeral river in Namibia, focusing on the native ana tree (Faidherbia albida) and the invasive mesquite (Prosopis spp.). We surveyed over 1,900 individual trees distributed across 24 sites along a 250 km stretch of the river...
2016: PeerJ
https://www.readbyqxmd.com/read/27798352/mitogen-activated-protein-kinase-p38-target-regenerating-islet-derived-3%C3%AE-expression-is-upregulated-in-cardiac-inflammatory-response-in-the-rat-heart
#11
Hanna Säkkinen, Jani Aro, Leena Kaikkonen, Pauli Ohukainen, Juha Näpänkangas, Heikki Tokola, Heikki Ruskoaho, Jaana Rysä
Regenerating islet-derived 3γ (Reg3γ) is a multifunctional protein, associated with various tissue injuries and inflammatory states. Since chronic inflammation is characteristics also for heart failure, the aim of this study was to characterize Reg3γ expression in cardiac inflammatory conditions. Reg3γ expression was studied in experimental rat models of myocardial infarction (MI) and pressure overload in vivo. For cell culture studies neonatal rat cardiac myocytes (NRCMs) were used. In addition, adenovirus-mediated gene transfer of upstream mitogen-activated protein kinase (MAPK) kinase 3b and p38α MAPK in vivo and in vitro was performed...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27795757/-cutaneous-depigmentation-in-black-female-population-for-cosmetic-purposes-results-of-a-kap-survey-conducted-in-abidjan-ivory-coast
#12
Sarah Kourouma, Ildevert Patrice Gbery, Mamadou Kaloga, Elidjé Joseph Ecra, Abdoulaye Sangaré, Isidore Yao Kouassi, Komenan Kassi, Alexandre Kouamé Kouassi, Pauline Yao Yoboué
INTRODUCTION: Cutaneous depigmentation for cosmeticis purposes is a widespread practice among black African women. It has many complications that have been well documented for decades. However, the reasons of practitioners are not well known. The aim of our study was to understand the motivating reasons of these women in order to conduct a communication campaign for behavior change. METHODS: We performed a cross-sectional KAP survey (Knowledge/Attitudes/Practices) at the Dermatology Department of the University Hospital of Treichville (Abidjan) Data were analyzed using Epi Info 3...
2016: Pan African Medical Journal
https://www.readbyqxmd.com/read/27790800/striae-as-a-predictive-clinical-marker-for-urogenital-dystopia-and-preventive-treatment-proposal
#13
P R Cunha, C B Mattos, A F Salai
Striae are common dermal lesions of unknown etiology. These stretch marks are linear and atrophic plaques due to the continuous and progressive distension of the skin (1,2,3). Their pathogenesis involves reductions and modifications in the configuration of the elastic fibers, collagen, and fibrillin of the dermis (3, 4), structures which are produced by fibroblasts. Striae and dystopic urogenital tissues have inactive fibroblasts causing deficiency in the contractility of the two conditions (4). This article is protected by copyright...
October 28, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27782420/characterization-of-the-primary-hydration-shell-of-the-hydroxide-ion-with-h2-tagging-vibrational-spectroscopy-of-the-oh-%C3%A2-h2o-n-2-3-and-od-%C3%A2-d2o-n-2-3-clusters
#14
Olga Gorlova, Joseph W DePalma, Conrad T Wolke, Antonio Brathwaite, Tuguldur T Odbadrakh, Kenneth D Jordan, Anne B McCoy, Mark A Johnson
We report the isotope-dependent vibrational predissociation spectra of the H2-tagged OH(-) ⋅ (H2O)n=2,3 clusters, from which we determine the strongly coordination-dependent energies of the fundamentals due to the OH groups bound to the ion and the intramolecular bending modes of the water molecules. The HOH bending fundamental is completely missing in the delocalized OH(-) ⋅ (H2O) binary complex but is recovered upon adding the second water molecule, thereby establishing that the dihydrate behaves as a hydroxide ion solvated by two essentially intact water molecules...
October 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27759615/photochemical-tissue-passivation-attenuates-av-fistula-intimal-hyperplasia
#15
Robert N Goldstone, Michael C McCormack, Rachel L Goldstein, Srivalleesha Mallidi, Mark A Randolph, Michael T Watkins, Robert W Redmond, William G Austen
OBJECTIVE: We hypothesized that decreasing vein compliance would protect the vein against stretch injury and reduce intimal hyperplasia (IH). BACKGROUND: Although arteriovenous fistulas (AVFs) are the criterion standard for vascular access, their effectiveness is limited by poor patency with 40% to 60% failing due to IH. Venous stretch injury from exposure to arterial pressure induces IH. Photochemical tissue passivation (PTP) crosslinks adventitial collagen, decreasing vein compliance to resemble that of an artery...
October 17, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27723079/development-of-a-stretch-induced-neurotrauma-model-for-medium-throughput-screening-in-vitro-identification-of-rifampicin-as-a-neuroprotectant
#16
Isabel López-García, Domokos Gerő, Bartosz Szczesny, Petra Szoleczky, Gabor Olah, Katalin Módis, Kangling Zhang, Gao Jungling, Ping Wu, Lawrence C Sowers, Doug DeWitt, Donald S Prough, Csaba Szabo
BACKGROUND AND PURPOSE: We hypothesized that an in vitro, stretch-based model of neural injury may be useful to identify compounds that decrease the cellular damage in neurotrauma. EXPERIMENTAL APPROACH: We screened three neural cell lines (B35, RN33B, SH-SY5Y) subjected to two differentiation methods and selected all-trans-retinoic acid-differentiated B35 rat neuroblastoma cells subjected to rapid stretch injury, coupled with a subthreshold concentration of H2 O2 , for the screen...
October 9, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27714048/skin-mountable-stretch-sensor-for-wearable-health-monitoring
#17
Jonathan D Pegan, Jasmine Zhang, Michael Chu, Thao Nguyen, Sun-Jun Park, Akshay Paul, Joshua Kim, Mark Bachman, Michelle Khine
This work presents a wrinkled Platinum (wPt) strain sensor with tunable strain sensitivity for applications in wearable health monitoring. These stretchable sensors show a dynamic range of up to 185% strain and gauge factor (GF) of 42. This is believed to be the highest reported GF of any metal thin film strain sensor over a physiologically relevant dynamic range to date. Importantly, sensitivity and dynamic range are tunable to the application by adjusting wPt film thickness. Performance is reliable over 1000 cycles with low hysteresis after sensor conditioning...
October 6, 2016: Nanoscale
https://www.readbyqxmd.com/read/27711718/water-bridges-anchored-by-a-c-ho-hydrogen-bond-the-role-of-weak-interactions-in-molecular-solvation
#18
Aditi Bhattacherjee, Sanjay Wategaonkar
The imidazole group, characterized by an activated C(2)-H bond sandwiched between two N atoms, occurs in several biomolecules including alkaloids, amino acids, and nucleobases. The speculated role of this potential hydrogen bond donor in shaping the solvation shell around the neutral imidazole moiety, however, remains unidentified. In contrast, hydrogen bonding and electrostatic interactions are commonly observed in the imidazolium cation where the acidity of the C(2)-H bond is markedly enhanced. Here, we show direct evidence of the weakly activated C(2)-H bond in shaping the solvation shell of neutral imidazole, via spectroscopic characterization of the water clusters (Wn, n = 2-4) of two model compounds, benzimidazole (BIM) and N-methylbenzimidazole (MBIM)...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27704760/crack-fold-hybrid-structure-based-fluidic-networks-inspired-by-the-epidermis-of-desert-lizards
#19
Junghwa Cha, Hyunjae Shin, Pilnam Kim
A bioinspired fluidic system with cracks and folds was introduced to emulate the structures and functions of desert lizards' integuments, which show marked ability of water management. Since there was a structural analogy between scales and interscalar channels of lizard's skin and cracks and folds of a bilayer elastic material, we can mimic lizard's skin by controlling the stress distribution on patterned elastomers. Our system showed not only capillary-driven water retention within confined fluidic network, but also stretching-driven biaxial water transport...
October 5, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27699731/the-effect-of-intramural-botulinum-toxin-injections-on-the-elongation-of-the-piglet-oesophagus-is-time-dependent
#20
Christian Bakholdt Dibbern, Morten Rose, Mark Bremholm Ellebæk, Niels Qvist
Introduction One in 4,000 infants is born with oesophageal atresia. Approximately 15% of these have a long gap oesophageal atresia, where primary anastomosis is difficult or impossible. Previous studies have shown an effect of intramural botulinum toxin type A (BTX-A) injections on the elongation and max load of the esophagus 1 hour after injection. We hypothesized that a longer waiting period of 2 hours could increase this effect. Methods Forty-five piglets were randomized into three groups. Two treatment groups received 2 units/kg of BTX-A and one group received saline...
October 3, 2016: European Journal of Pediatric Surgery
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